trifunctional aminoamide cellulose derivative and its characterization
Post on 19-Dec-2015
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Trifunctional Aminoamide Cellulose Derivative and its
Characterization
Outline
• Objectives• Problem statement and motivation of
the study• Presuppositions from Literature• Methodology
Objectives
• To illustrate how to use a couple of techniques to confirm the structural of a newly synthesized material and its intermediate.
• To illustrate how to use a couple of techniques to characterize a final product and so provide some information for applications.
Problem statement and motivation of the study
• What are dendrimers?• “A dendrimer is a
molecule with a form like the branches of a tree.”[1]
• Dendrimers can be used in pharmaceutics, genetics, catalyst chemistry and superconductor currently or potentially. [2][1] Wikipedia
[2] Sand, Anders. Dendrimers and Their Technical Applicability
Cellulose-based dendrimers
Zhang, Changde et al. Biomacromolecules (2006), 7(1), 139-145.
Presuppositions from Literature
• Narrow molecular weight distribution
• The most exciting physical property of dendrimers is the variation of their intrinsic viscosities with molecular weight. [6] It is found that, when the generation increases beyond a certain point, the intrinsic viscosity begins to decline, contrary to the behavior of linear polymers (Fig.4).
[6] http://www.dendritech.com/pamam.html
Methodology
• Using 1H to confirm the structural of intermediate product:
• Using FT-IR to confirm and characterize the structural of CMCBA and CMCBADMPDA:
• Using NMR to confirm and characterize the structural of CMCBA and CMCBADMPDA:
• Using TGA to Characterize the Degree of Substitution of CMCBA and CMCBADMPDA:
• Using Intrinsic Viscosity to characterize the conformation of CMCBADMPDA:
• Using GPC-LS to characterize the MW and MWD of CMCBADMPDA:
Using 1H to confirm the structural of intermediate product:
Using FT-IR to confirm and characterize the structural
Using NMR to confirm and characterize the structural of CMCBA
and CMCBADMPDA:
Using TGA to Characterize the Degree of Substitution
Using Intrinsic Viscosity to characterize the conformation
• CMC 5.62 dL/g, • CMCDMPDA 3.57 dL/g • CMCBADMPDA 0.39 dL/g
Using GPC-LS to characterize the MW and MWD of CMCBADMPDA:
Conclusions
• The author got the “right ” product.• The product is of very low viscosity,
which is suitable for drug delivery.