ProfessorC.Kiparissides CERTH/CPERI

Treatment of CNS Disorders

Ø  N2B delivery of medica*ons for CNS disorders as analterna*vetointravenousdelivery.

Ø  N2B-patch:Applica*onof an in situ forming hydrogelcontainingdrugloadedNPstotheolfactoryepitheliumviaanendoscopiccatheter.

Ø  Mul5plepathways to thebrain through theolfactoryregion

Ø  Very complex problem requiring contribu*ons frommanydisciplines

ProfessorC.Kiparissides CERTH/CPERI

Many and Different Models!

Drug release from the hydrogel to mucosa Hydrogel swelling and shrinkage

Drug release from embedded par:cles

0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0

5.0x105

1.0x106

1.5x106

2.0x106

2.5x106

3.0x106

3.5x106

pH = 5pH = 5 .5pH = 6pH = 6 .5pH = 7

Weigh

tAve

rage

Molec

ularW

eigh

t

T ime (m in)

Simula:on of gela:on kine:cs

Key mechanisms of hydrogel film forma:on

HA droplet spreading

HA droplet spreading over the olfactory mucous surface

Mucous layer

Flux JpR(t)

Hydrogellayerz

⎟⎠

⎞⎜⎝

⎛= )t,0(

dzdC,tfJ H

m

CH(z)

( ))t,z(C),t,r(C),t(RfJ Hp =1 2

4 3

Jm(t)

Jp(t)

N2B Drug Transport Mechanism and drug release profile

ProfessorC.Kiparissides CERTH/CPERI

Vocabulary in N2B-patch Modelling

Miss-matchandconfusioninvocabularyandlanguage!

OntologicalClassifica*on

ChemicalEngineering

FluidDynamics,Rheology,Mixing,Interfacialmechanics,Masstransfer,Kine*cs,Geldynamics

Pharmacology&Biology

Toxicity,DrugDelivery,Brainpenetra*on,Drugload,Effec*vedose,Drugdeac*va*on

Medical&End-user

Effec*veness,user-friendliness,Simplicity,ease-to-use,cost,long-termeffects

“Languages”:ChemicalEngineeringBio-medicalEngineeringPharmacologyBiologyMaterialsScienceMedicalPa*ents

ProfessorC.Kiparissides CERTH/CPERI

Modelling Outline in N2B-patch Following directives of H2020 LEIT-NMBP Programme Materials and Nanotechnology Projects