transparent mxene microecog electrodes for multi-modal ... · cnt: carolyn wilkinson, everett...
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Transparent MXene MicroECoG Electrodes for Multi-Modal Seizure Monitoring
Gari EberlyPhD students: Nicki Driscoll and Brendan Murphy
PI: Dr. Flavia VitaleCenter for Neuroengineering and Therapeutics
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Epilepsy“Disorder of the brain characterized by the predisposition to
generate epileptic seizures”
[1] Epileptic seizures and epilepsy… Epilepsia, 46(4), 470-472.
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Need to develop more effective treatments for epilepsy
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Need to develop more effective treatments for epilepsy
Development requires characterization of behavior and pathway of seizure
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Need to develop more effective treatments for epilepsy
Development requires characterization of behavior and pathway of seizure
Must monitor seizure on micron level with high temporal and spatial resolution
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Develop a micro-electrocorticographic device capable of multi-modal seizure monitoring
Two-Photon Imaging
Electrophysiological Recording
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Develop a micro-electrocorticographic device capable of multi-modal seizure monitoring
[2] Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging. Nature communications, 5, 5259.
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Develop a micro-electrocorticographic device capable of multi-modal seizure monitoring
[3] Epidural and foramen-ovale electrodes in the diagnostic evaluation of patients considered for epilepsy surgery. Epileptic disorders : international epilepsy journal with videotape. 12. 48-53.
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MXene (Ti3C2Tx)
✓Sheet resistance(47 Ω/sq at 62 nm)
✓Volumetric Capacitance(676 F cm−3)
✓Conductivity(10,000 S/m)
✓Biocompatible✓Flexible✓Hydrophilic
[4] High-Capacitance Mechanism for Ti3C2Tx MXene by in Situ Electrochemical RamanSpectroscopy Investigation. ACS nano, 10 12, 11344-11350 .
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Fabrication and CharacterizationUse MXene to create transparent Micro-ECoG electrodes
Optimize spray coating procedure
Characterize MXene electrodes using electrochemical impedance spectroscopy and UV-Vis spectroscopy
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1 2
Si Parylene-C Gold MXene SiO2 Al
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2 3
Si Parylene-C Gold MXene SiO2 Al
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3 4
Si Parylene-C Gold MXene SiO2 Al
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4 5
Si Parylene-C Gold MXene SiO2 Al
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5 6
Si Parylene-C Gold MXene SiO2 Al
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6 7
Si Parylene-C Gold MXene SiO2 Al
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8
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Final8
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Gold Pads
MXene Traces
Parylene-C Encapsulation
1.5 mm
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Device CharacterizationObserved optical transparency and film quality
UV-Vis Spectroscopy - more precisely characterize transparency of Ti3C2Tx films at wavelengths ranging from 340-1000 nm
Electrochemical impedance spectroscopy (EIS) - characterize impedanceof the Ti3C2Tx electrodes.
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Bright Field Microscopy
Graphene 10 - MXene 5 - MXene 15 - MXene
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UV –Vis Spectroscopy
Transmittance at 550 nm:
5 Sprays: 74 ± 1%
10 Sprays: 68.2 ± .8%
15 Sprays: 44.2 ± .5%
Common λ - Two-Photon Imaging
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EIS
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Impedance at 1 kHz:
5 Sprays: 280 ± 73 kΩ
10 Sprays: 46 ± 14 kΩ
15 Sprays: 5 ± 1 kΩ
Graphene: 2110 ± 98 kΩ
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Graphene 10 - MXene
5 - MXene 15 - MXene
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Thank you!!REU Students: Tessa Posey, Nancy Rodriguez Mentors: Nicki Driscoll, Brendan Murphy, Dr. Nick ApolloPIs: Dr. Flavia Vitale and Dr. Brian LittCNT: Carolyn Wilkinson, Everett PrinceSingh REU: Kristin Field, Eric Johnson
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Transparent MXene MicroECoG Electrodes for Multi-Modal Seizure Monitoring
Gari EberlyPhD students: Nicki Driscoll and Brendan Murphy
PI: Dr. Flavia VitaleCenter for Neuroengineering and Therapeutics