transient soft-tissue edema associated with implantation of increasing doses of rhbmp-2 on an...

Transient Soft-Tissue Edema Associated with Implantation of Increasing Doses of rhBMP-2 on an Absorbable

Collagen Sponge in an Ectopic Rat Model

by Hyun W. Bae, K. Brandon Strenge, Nomaan Ashraf, Jeffrey M. Badura, Steven M. Peckham, and William F. McKay

J Bone Joint Surg AmVolume 94(20):1845-1852

October 17, 2012

©2012 by The Journal of Bone and Joint Surgery, Inc.

Treatment rotation scheme.

Hyun W. Bae et al. J Bone Joint Surg Am 2012;94:1845-1852


Average edema volumes as determined with quantitative MRI in Part I.



Sample MRIs from Part I demonstrating the increased signal intensity observed at the sites of the implants at two days.



Sample T2-weighted MRIs from Part I demonstrating the increased signal intensity observed at the sites of the implants at seven days.



Histological images (hematoxylin and eosin, ×40) obtained two days after treatment with the 0-μg (Fig. 5-A), 30-μg (Fig. 5-B), 129-μg (Fig. 5-C), and 450-μg (Fig. 5-D) doses of rhBMP-2 on the ACS.

Note the residual ACS carrier (brown arrows) with increased ...



Histological images (hematoxylin and eosin, ×200) obtained seven days after treatment with the 0-μg (Fig. 6-A), 30-μg (Fig. 6-B), 129-μg (Fig. 6-C), and 450-μg (Fig. 6-D) doses of rhBMP-2 on the

ACS. Note the residual ACS carrier (brown arrow) and the minim...



Average edema volumes as determined with quantitative MRI in Part II.



Sample MRIs from Part II. The image on the left demonstrates the increased signal intensity observed in the groups containing rhBMP-2 on the ACS carrier (rhBMP-2/ACS Implants).



transient soft-tissue edema associated with implantation of increasing doses of rhbmp-2 on an...

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