transforming healthcare: the quantification of everything
Upload: institute-of-systems-science-national-university-of-singapore
Post on 21-Apr-2017
11.354 views
TRANSCRIPT
TRANSFORMING HEALTHCARE
THE QUANTIFICATION OF
EVERYTHINGSTEVEN TUCKER, MD, FACP, FAMS
Global Health Advisor, SingTel Founder, Tucker Medical
WARNING !
We tend to overestimate the effect of a technology
in the short run and underestimate the effect
in the long run.
Roy AmaraCo-founder, Institute for the Future
1EXPONENTIALS
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
EXPONENTIALS
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
COMPUTING POWER
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
MOORE’S LAW
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
MOORE’S LAW
Computers
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
MOORE’S LAW
ComputersSensors
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
MOORE’S LAW
ComputersSensors
Biology
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
MOORE’S LAW
ComputersSensors
Pan-omicsBiology
2PROBLEMS
Healthcare is not a science problem, it’s an information problem.
-Thomas Goetz
DIABETES
382Million
Source: International Diabetes Federation
OBESITY
500Million
Source: World Health Organisation
HEART DISEASE
17.3Million
Source: World Health Organisation
CANCER
14.1Million
Source: World Health Organisation
3SENSORS
If you cannot measure it, you cannot improve it.
-Lord Kelvin
SENSOR EVOLUTION
Sensor 1.0
Sensor 2.0
Sensor 3.0
Ability to measure + record signal
Sensor web integration; share + access data
Passive data gathering + aggregating + meaningful insight
ACTIVITY
HEALTH
MEDICAL
THE TRICORDER
VITAL SIGNS
EMERGENCY
BIRTH CONTROL
WIRELESS BIRTH CONTROL
4BIOLOGY
THERANOS
RETAIL LABS
HOME TRACKING
HOME DIAGNOSIS
HOME DIAGNOSIS
LAB ON A CHIP
CELL CAPTURE
LIQUID BIOPSY
GENOME MATH
23Pairs ofchromosomes
GENOME MATH
20kGenes
GENOME MATH
4Bases
A - TG - C
GENOME MATH
3.2Base pairsper genome
billion
GENOME MATH
3.2billion BP
40x Coverage
128billiondata points
SEQUENCING $
GENOMICS 2001
GENOMICS 2007
GENOMICS 2013
GENOMICS 2014
GENOMICS 2014
GENOMICS 2016
GENOMICS 2018
NEXT GEN SEQUENCING
NEXT NEXT GEN
SEQUENCING
?
5PLATFORMS
$2.4Billion
$26Billion
SENSORS
SENSORSGyroscope Proximity
SENSORSGyroscope
Gesture
Proximity
Fingerprint
SENSORSGyroscope
Gesture
Proximity
Compass
Fingerprint
Hall cover
SENSORSGyroscope
Gesture
Heart rate
Proximity
Compass
Barometer
Fingerprint
Hall cover
SENSORSGyroscope
Ambient light
Gesture
Heart rate
Accelerometer
Proximity
Compass
Barometer
Fingerprint
Hall cover
6PAN-OMICS
Exposome
Hg80
Cd48
33
Pb82
Ti81
Ni28
As
PhenomeEpigenome
!TRANSFORM
Digital Health as Google Map
SENSOR ACTIVITY
GENOME
MICROBIOME
LAB
PHENOME
UNIQUE PERSON
DIET
HEALTH AS A GOOGLE MAP
Digital Health as Google Map
SENSOR ACTIVITY
GENOME
MICROBIOME
LAB
PHENOME
UNIQUE PERSON
DIET
HEALTH AS A GOOGLE MAP
6P4
MEDICINE
P4 MEDICINE
1. Predictive 2. Preventive 3. Personalized 4. Participatory
1. Predictive 2. Preventive 3. Personalized 4. Participatory
100k WELLNESS PROJECT
P4 MEDICINE
Predictive You will track your health. It’s your data. Identify transition states.
P4 MEDICINE
Preventive Wellness networks. Illness networks. A systems-based approach to repair and maintenance.
P4 MEDICINE
Personalized You are your own control. Your health data cloud. Molecular + Environmental.
P4 MEDICINE
Participatory Transformative for health. Societal change - enormous. Patients will adapt. Doctors may adapt?
Health Status 20% of patients = 80% of costs
VALUE COST
Healthy Low Risk At Risk High
Risk
Chronic Disease
Early
Active Disease
Chronic Disease
Progression
End of Life Care
THE PIVOT
6LONGEVITY
Life Expectancy at birth
70
73
76
79
82
85
Years of Educa>on< 12 12 13-‐15 > 16
1990 2000 2008 1990 2000 2008 1990 2000 2008 1990 2000 2008
TECHNOLOGY
BIOLOGY
CALICO
7AND…
THANK YOUFor your 9me & a>en9on