Training in Pathology InformaticsFunding Opportunities

Michael J. Becich, MD PhDCourse Director, APIII (http://apiii.upmc.edu)Chairman, Dept of Biomedical Informatics

Professor of Biomedical Informatics, Pathology, Information Science and Telecommunications

(http://www.dbmi.pitt.edu)Center for Clinical and Translational Informatics

(http://www.ctsi.pitt.edu/content.asp?id=1435)

Overview

• NCRR - CTSA Clinical Research Training Programs

• NLM - Biomedical Informatics Training Programs

• Quantitative Mentored Investigator Awards• K99/R00 • CAP Foundation and Industry Funding• Conclusions

ClinicalClinical

CommunityCommunity

National Center for Research ResourcesAccelerating research from basic discovery to improved patient care

Improved Improved patient patient

carecare

Pre-clinicalPre-clinical

animal model resources

imaging & informatics advances

clinical research support

research capacity

& training

community engagement

science education

NIH Roadmap – http://nihroadmap.nih.gov

mouse

MRI insertiontube

NCRRhttp://ctsaweb.org/

Building A National CTSA ConsortiumBuilding A National CTSA Consortium 38 Sites with CTSA Awards since 2006 (Goal = 60)38 Sites with CTSA Awards since 2006 (Goal = 60)

Funded CTSA sitesFirst Round - 2006

• Duke Clinical and Translational Science InstituteDuke University

• Irving Institute for Clinical and Translational Research Columbia University

• Mayo Center for Translational Science ActivitiesMayo Clinic

• Oregon Clinical and Translational Research InstituteOregon Health and Science University

• Rockefeller University Center for Clinical and Translational ScienceThe Rockefeller University

• The UCSF Clinical and Translational Science InstituteUniversity of California, San Francisco

• UC Davis Clinical and Translational Science CenterUniversity of California, Davis

• University of Pennsylvania Institute for Translational Medicine and TherapeuticsUniversity of Pennsylvania

• University of Pittsburgh Clinical and Translational Science InstituteUniversity of Pittsburgh

• University of Rochester Clinical and Translational Sciences InstituteUniversity of Rochester School of Medicine and Dentistry

• University of Texas Houston Center for Clinical and Translational SciencesUniversity of Texas Health Sciences Center at Houston

• Yale Center for Clinical InvestigationYale University

Funded CTSA sitesSecond Round - 2007

• Atlanta Clinical and Translational Science Institute (Atlanta-CTSI)Emory University (partnering with Morehouse School of Medicine)

• CTSA at Case Western UniversityCase Western University

• CTSA at Weill Cornell Medical College Weill Cornell Medical College (partnering with Hunter College)

• Johns Hopkins Institute for Clinical and Translational Research Johns Hopkins University

• Michigan Institute of Clinical and Health Research University Of Michigan At Ann Arbor

• North and Central Texas Clinical and Translational Science Initiative University of Texas Southwestern Medical Center – Dallas

• University Of Wisconsin Madison Institute for Clinical and Translational ResearchUniversity Of Wisconsin Madison

• University of Chicago CTSAUniversity Of Chicago

• University of Iowa's Institute for Clinical and Translational Science University Of Iowa

• University of Washington Institute of Translational Health Sciences University Of Washington

• Vanderbilt Institute for Clinical and Translational ResearchVanderbilt University (partnering with Meharry Medical College)

• Washington University Institute of Clinical and Translational SciencesWashington University

Funded CTSA sitesThird Round - 2008

• Albert Einstein-Montefiore Institute for Clinical and Translational ResearchAlbert Einstein College of Medicine (partnering with Montefiore Medical Center)

• Clinical and Translational Science (BU-BRIDGE) Institute Boston University • Colorado Clinical and Translational Sciences Institute University of Colorado Denver • Harvard Catalyst: The Harvard Clinical and Translational Science Center

Harvard University • Indiana Clinical and Translational Science Institute

Indiana University School of Medicine • Institute for Integration of Medicine and Science (IIMS)

The University of Texas Health Science Center at San Antonio • Northwestern University Clinical and Translational Sciences Institute

Northwestern University • The Ohio State University Center for Clinical and Translational Science

The Ohio State University • The Scripps Translational Science Institute

The Scripps Research Institute • The Stanford Center for Clinical and Translational Education and Research

Stanford University • Translational and Clinical Science (TraCS) Institute

The University of North Carolina at Chapel Hill • Tufts Clinical and Translational Science Institute

Tufts University • UAB Center for Clinical and Translational Science

The University of Alabama at Birmingham • University of Utah Center for Clinical and Translational Science

The University of Utah

52 Sites with CTSA Planning Grants

• Brown University• Children's Research Institute• Dartmouth College• Emory University• Georgetown University• Harvard University Medical School• Howard University• Pennington Biomedical Research Center• Medical College of Georgia• Medical College of Wisconsin• Medical University of South Carolina• Meharry Medical College• Methodist Hospital Research Institute• Michigan State University• Mount Sinai School of Medicine• New York University School of Medicine• Stanford University• State University New York• Temple University• Texas A&M University Health Science Center• Translational Genomics Research Institute• University of Massachusetts Medical School• University of Medicine Dentistry of New Jersey• University of Alabama• University of Arkansas for Medical Sciences• University of Cincinnati

• University of Colorado Denver Health Sciences• University of Connecticut School of Medicine • University of Florida• University of Hawaii• University of Illinois• University of Kansas Medical Center• University of Kentucky• University of Louisville• University of Maryland School of Medicine• University of Missouri• University of New Mexico • University of North Carolina• University of North Dakota• University of Oklahoma Health Sciences Center• University of South Carolina • University of South Florida• University of Southern California• University of Tennessee Health Science Center• University of Texas Health Science Center • University of Virginia• University of Washington• University of Wisconsin• Virginia Commonwealth University• Wake Forest University Health Sciences• Wayne State University• Weill Medical College Cornell University

Informatics at first 12 CTSA sitesMJB’s Impression (disclaimer!!!)

SiteCore, Ctr, Inst, Dept

Research IT

Clinical Trials DB

EducationData

Warehouse

Bioinformatics

Clinical Info

Web Portal

Vocab Ontology

Architecture

Biospecimen Info

Columbia Core Yes Yes Yes Yes Yes YesDuke Core Yes Yes YesMayo Core Yes Yes Yes Yes Yes Yes Yes

Oregon Core Yes Yes YesRockefeller Core Yes Yes YesUC Davis Core Yes Velos Yes Yes Yes

UCSF Core Yes Yes Yes Yes YesU Penn Ctr(s) x 2 Yes Yes Yes YesU Pitt Dept, Ctr Yes Yes Yes Yes Yes Yes

U Rochester Core Yes Yes Yes Yes YesUTHSC Core Yes Yes Yes Yes Yes Yes Yes

Yale Core Yes Yes Yes Yes Yes Yes Yes12 8 8 7 6 5 5 4 3 3

• All Twelve CTSA sites have a component of Research IT support– Includes implementation, enhancement, support of existing systems

• Pathology Informatics is grossly under-represented (except maybe in Tissue Banking Informatics)

• Punch line – every program in CTSA (as a requirement for funding) has to have a training program in clinical research and have a biomedical informatics core!!!

CTSA Training Programs

• CTSA has (by requirement) training programs (K and T programs of NIH) and clinical and translational research centers (CTRCs, formerly GCRCs)

• K Programs (for junior faculty) – • Career Development and Mentorship Programs• Clinical Research Scholars Program• Focus is to take MDs and train them in clinical research• Pathology is not taking advantage of this major opportunity

• T Programs (for residents and fellows)• Clinical Research Training Program

– Certificate program (1 yr) available at most institutions

• Designed for trainees – clinical & translational research fellowship• Pathology is not taking advantage of this major opportunity

Total number of active trainees Total number of active trainees

0

20

40

60

80

100

120

140

160

2000 2001 2001 2003 2004 2005 2006

Non-degreeStudentsResidentsCRSP (K12)CETPCRTP

NLM Biomedical Informatics Training Programs = 20

http://www.nlm.nih.gov/ep/GrantTrainInstitute.html

NLM Biomedical Informatics Training Programs = 18

• 1. University of California Irvine Irvine, CA, Program contact: Pierre Baldi • 2. University of California Los Angeles Los Angeles, CA, Program contact: Alex Bui• 3. Stanford University  Stanford, CA, Program contact: Russ Altman • 4. University of Colorado Denver/ Aurora, CO, Program contact: Larry Hunter  • 5. Yale University New Haven, CT, Program contact: Sandra Frawley • 6. Regenstrief/Indiana University Indianapolis, IN, Program contact: Steve Downs • 7. Harvard University Boston, MA, Program contact: Lucila Ohno-Machado • 8. Johns Hopkins University Baltimore, MD, Program contact: Kersti Winny  • 9. University of Missouri-Columbia Columbia, MO, Program contact: Bill Caldwell • 10. Columbia University Health Sciences NY, NY Program contact: Marina Honablue • 11. Oregon Health & Science University Portland, OR; Program contact: Bill Hersh • 12. University of Pittsburgh Pittsburgh, PA; Program contact: Toni Porterfield • 13. Vanderbilt University Nashville, TN; Program contact: Cindy Gadd • 14. Rice University Houston, TX; Program contact: Tony Gorry • 15. University of Utah Salt Lake City, UT; Program contact: Scott Narus • 16. University of Virginia Charlottesville, VA; Program contact: Stephanie Guerlain • 17. University of Washington Seattle, WA; Program contact: Brian Brown • 18. University of Wisconsin Madison Madison, WI; Program contact: Louise Pape

NOTE: Red #s are sites that do not yet have a CTSA Funded Training Program

NLM Training Programs

• Focused on 3 types of training:– PhD – major focus

– MS – major focus

– Certificates (one year generally) – excellent for Pathology Informatics trainees

• Great for informatics networking even if your program is “stand alone”

• Short term training opportunities also available – summer, 3 month rotation

• Major demand see 10x10 program – http://www.amia.org/10x10

Quantitative Mentored Investigator Award (K25)

NIH Pathway to Independence (PI) Award (K99/R00) http://grants.nih.gov/grants/guide/pa-files/PA-07-297.html

 

 

 

The K25 award will provide support and “protected time” for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research.

Requires mentorRequires training planRequires research plan

http://grants.nih.gov/grants/guide/pa-files/PA-06-087.html

K99/R00 (so called “kangaroo”)Pathway to Independence Awards

  Purpose

The NIH Pathway to Independence Award will provide up to five years of support consisting of two phases. The initial phase will provide 1-2 years of mentored support for highly promising, postdoctoral research scientists. This phase will be followed by up to 3 years of independent support contingent on securing an independent research position. The PI Award is limited to postdoctoral trainees. This program expires January 3, 2010 unless reissued. NLM supports research career development in biomedical informatics and bioinformatics. We define informatics as the intersection of computer, information and behavioral sciences with one or more application domains. Application domains of interest include health care delivery, basic biomedical research, clinical and translational research, public health and others. Whatever the application domain, the research career focus must be informatics. Preference will be given to applicants who received their informatics training at one of NLM's university-based training programs in Biomedical Informatics.

  NLM ContactClinical and Public Health Informatics: Dr. Hua-Chuan Sim, simh@mail.nih.govBioinformatics and Computational Biology: Dr. Jane Ye, yej@mail.nih.gov

 

Deadlines for New Applications: February 12, June 12, and October 12 each yearDeadlines for Revised Applications: March 12, July 12, and November 12 each yearFull listing of deadlines for competing applications: http://www.nlm.nih.gov/ep/Deadlines.html

NIH Pathway to Independence (PI) Award (K99/R00) http://grants.nih.gov/grants/guide/pa-files/PA-07-297.html

 

 

 

CAP Foundation

Scholars Research Program – sponsored by CAP and SeraconAward Amount:     Up to $12,500 for six months Up to $25,000 for one year

• Intended for salary support. Recipient’s institution is expected to contribute benefits and overhead costs and may provide a support supplement. Assurance must be given that facilities and direct support sufficient for the work proposed by the applicant will be provided throughout the term of the grant.

• This award is made to the scholar, not the institution. It may, with cause, be terminated at any time. Recipients who choose not to accept the award may list the recognition on their curriculum vitae.

• Purpose: The purpose of the award is to help facilitate the transition from residency to an independent investigator. Therefore, persons who have already been awarded major research support for the previous academic year will not be eligible.

• Time Commitment: Projects must be completed within one (1) year. For those who are in a second year fellowship, the project must be completed within three (3) years after completing residency. Applicants must plan to spend their fellowship year in basic or applied research, and are expected to work full-time as defined in their project plan.

• Eligibility: Residents at the PGY 2 level, and up to those doing a second year fellowship. Residents who are more than three years post-residency training are not eligible. Applicants must be a CAP Member or have an application pending.

• http://www.cap.org/apps/cap.portal?_nfpb=true&_pageLabel=foundation

CAP Foundation

Advanced Training in Pathology Informatics - Sponsored by McKesson• Award Amount: Allowance provided for travel and living expenses. It is expected that the

recipient’s own institution will continue to provide for salary and benefits during the award period.

• Purpose: To offer background and experience to pathology residents to introduce and implement advanced informatics technology in the clinical laboratory. After the rotation, the resident will be able to:

• Identify the following factors important in introducing and utilizing new information technology in the clinical laboratory:

– Medical decision support systems and artificial intelligence – Electronic medical record – Digital multimedia and imaging applications– Telepathology and telemedicine – Outcomes research and data mining – Process control, quality control, and quality assurance

• Demonstrate ability to recognize and utilize information concerning new trends and technology in pathology.

• Commitment: Four (4) weeks, must be completed between 5/1/09 – 8/31/09.• Eligibility: Pathology residents or those in fellowships. It is a requirement that candidates have

adequate training and experience in informatics. Applicants must be a CAP Junior Member.

CAP Foundation

Research in Telepathology - Sponsored by Nikon• Award Amount: $5,000 to cover expenses incurred during

the grant period, and for travel to attend a national meeting to present an abstract/paper summarizing study results.

• Purpose: To further developments in and use of information technology for the practice of pathology.

• Time Commitment: This grant is intended to facilitate a six-month study.

• Eligibility: Pathology residents and those in fellowships who are still in training. Applicants must be a CAP Junior Member or have an application pending.

CAP Foundation

Research in Telepathology - Sponsored by Olympus• Award Amount: $5,000 to cover expenses incurred during

the grant period, and for travel to attend a national meeting to present an abstract/paper summarizing study results.

• Purpose: To further developments in and use of information technology for the practice of pathology.

• Time Commitment: This grant is intended to facilitate a six-month study.

• Eligibility: Pathology residents and those in fellowships who are still in training. Applicants must be a CAP Junior Member or have an application pending.

Conclusions

• Pathology Informatics trainees should consider clinical research training programs in CTSA sites – 38

• Pathology Informatics trainees should consider biomedical informatics training programs – 18

• Other funding opportunities exist in your institution, foundations and from industry– Communicate with CAP Foundation

• Make it happen, there are options!!!

End of Talk – e-mail me at End of Talk – e-mail me at becich@pitt.edubecich@pitt.edu if if you have questions or need clarifications you have questions or need clarifications

about the discussion.about the discussion.

NOTE: Please e-mail me if you want a copy of this presentation or contact me for additional help in training

resources nationally – 412-623-3941