Towards synthetic 3D dynamic cardiac Imaging

Isabelle E. Magnin

CREATIS-LRMNCNRS UMR 5220, Inserm U 630, Université Lyon 1, Insa-Lyon

http://creatis.insa-lyon.fr

CREATIS - LRMNCREATIS - LRMNMedical Imaging Center – LyonMedical Imaging Center – Lyon

http://creatis.insa-lyon.fr

180 people (65 Ph D students)180 people (65 Ph D students)

Doua Campus

Est Hospital

ESRF, Grenoble

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Complex Anatomy

short axisLong-axis

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Magnetic Resonance Imaging

(MRI)

1,5 T Siemens Vision

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Multimodal cardiac imaging MRI

Anatomie

Siemens, Sonata

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Heart anatomical surfaces and volumes

3D SPECT, XRaysor MRI

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3D multimodal cardiac images

Creatis & INRIA

3D deformable finite elements

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Deformable elastic template for 3D segmentation (Quoc Cuong Pham, PhD thesis Creatis, INPG, 2002)

Initial templateNodes : 5197, Elements : 22368

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LV+RV

Mapping functional data onto a surfacic model

Medial surface computation

LV Medial surface

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Medial surface

Endocardial surface

Epicardial surface

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PET imaging Siemens ECAT 931

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Multimodal cardiac imaging

Metabolism

FDG PET emission-image

PET transmissionimage

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Surface-based registration of thorax structures

deformable pyramid approach [Lötjönen et al.,1999]

Rigid PET-MR image registration method

MRI transaxial

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PET transmission

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3D functional cartographies PET (Glucosis uptake)

Patient 1

Patient 2

max 0 max0

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Recording Electro-magnetic activity Magneto-cardiography

MCG data (10 patients)

-BioMag laboratory (Helsinki University Central Hospital, HUCH) - 99-channel MCG device (Neuromag, Helsinki, Finland)

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Cartography of the electromagnetic activity (MCG)

2D conventional

New 3D Model

[Mäkela et al. 2003]LRMN

3-D Functional cardiac maps

Quantitative perfusion computed from 3-D FDG Positron Emission Tomography (PET)

(coll. Cermep, Lyon) 17

L VElectromagnetic field

computed from Magnetocardiography

(coll. Helsinki LBME)

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Physiology modelingPhysiology modeling

• modeling organs anatomy, dynamics and modeling organs anatomy, dynamics and physiology physiology

• complex elastic and moving structurescomplex elastic and moving structures• electrophysiological modelselectrophysiological models• bio-mechanical model (FEM)bio-mechanical model (FEM)• Biological, cellular modelsBiological, cellular models

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A new fully-digital anthropomorphic and A new fully-digital anthropomorphic and dynamic thorax/heart modeldynamic thorax/heart model

R. Haddad, I.E. Magnin, and P. ClarysseR. Haddad, I.E. Magnin, and P. ClarysseAugust 2007August 2007

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Outline

Motivations and objectivesMotivations and objectives Difficulties Difficulties Thorax/ Heart model construction Thorax/ Heart model construction Multimodality virtual imaging of the heart Multimodality virtual imaging of the heart Conclusions and Perspectives Conclusions and Perspectives

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Evaluation of cardiac/thoracic image analysis algorithms• Segmentation and motion tracking of cardiac/thoracic structures

• Multimodal Image Registration

• Thorax and heart image reconstruction in dynamic tomography

Motivations Motivations

See:

Schaerer et al., Automatic segmentation in MRI sequences,

EMBC 2007, SaP1B4.5

Need for a reference

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:

Synthetic Imaging Synthetic Imaging

Simulated realistic sequencesMRI, TEP, CT, US..

In vivo imaging acquisitions

A Virtual reference breathing thorax - beating heart model

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Building the breathing thorax / Beating heart model:

1. MRI Reference image data acquisitions

2. Anatomic 3D static models (thorax & heart)

3. Models animation

Breathing thorax/ Beating heart model

4. Models synchronization

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3. Models animation Displacement fields fitting :

Successive multi-levels non rigid FFD registrations

Deformation of the 3D model

Delhay, PhD thesis 2006

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2D displays of 3D estimated displacement fields (slice at medium level)2D displays of 3D estimated displacement fields (slice at medium level)

mid-systole end-diastole early-diastole

Magnitude mm

0,00

6,00

1,50

3,00

4,50

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Evolution of the LV and LA volumes during the CCEvolution of the LV and LA volumes during the CC

22204 14126 1082 2816 18 2624

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Dynamic combined Thorax/Heart model

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