TOPIGSBalanced Breeding

Outstanding performance

+ Safe Food

Rene ten BrinkeMarch 31 Ho Chi Minh City; Vietnam

Tainted pork is latest food scandal to hit China, March 17, 2011

------Products marketed under Shuanghui Group's Shineway brand were produced from pigs that were fed clenbuterol, an additive that can speed up muscle building and fat burning to produce leaner pork, the reports said.The additive, known among farmers as "lean meat powder", is banned in China because if eaten by humans it can lead to dizziness, heart palpitations and profuse sweating, the reports said……

2

3

Recent history

1910: Start of Herdbooks 1990: Merger of Herdbooks 1996: Acquisition of Dalland 1998: Acquisition of Fomeva 1999: Founding of TOPIGS 2003: Acquisition of Dumeco Breeding 2008: Merger of Dutch A.I.’s into Varkens K.I. Nederland as

part of TOPIGS

Result: The National Dutch herdbook breeding program again in one company

4

Mission TOPIGS

MISSION: a reliable supplier of genetic material, reproductive techniques and the related expertise and services

TOPIGS: target groups are professional pig farmers and integrated farms/producers

TOPIGS: cooperation of pig farmers for pig farmers

5

TOPIGS key facts & figures

Leading in pig genetics Worldwide > 550 employees Active in more than 55 countries Turnover € 98 million (2010)

Sales: > 1.2 million gilt-equivalents / year > 7 million doses of semen / year

Market leader in the Netherlands (>85%) Market leader in Europe Market leader outside USA

6

TOPIGS stands for:

Innovation: develop products and concepts that improve breeding and focus on efficient pork production

Sustainability: keeping the long term interests of our stakeholders in mind: environment, animal welfare and genetic diversity

Global: apply our specialist knowledge based on global presence.

Partnership: help clients and stakeholders solve problems and maximize added value

Trust: build solid relationships based on trust

TOPIGS=

Breeding

8

Climate zonesDesert (dry/hot)Tropical (wet/hot)MediterraneanTemperateContinental

9

Heat stress

Pigs are not able to sweat and pant

Thermo-neutral zone of sows: Range of temperatures between which an animal

feels comfortable Between 12°C and 22°C (Black et al., 1993

Sows inseminated during hot period have lower reproductive performance

10

7.07.58.08.5

9.09.5

10.010.5

10 12 14 16 18 20 22 24 26 28 30 32 34 36 38Maximum temperature at day of insemination

Farro

wing

rate

* Li

tter s

ize

Mean line 1 Mean line 2 Estimate line 1 Estimate line 2

Farrowing rate x litter size Spanish dataset

weaned piglets/sow/year

Line 1 Line 2

20°C 25.3 24.1

30°C 22.0 23.7

11

SOW LINE PROGRAMTOPIGS International

12

TOPIGS Sow lines

B-line Z-lineA-lineYork/Large White

F-line N-lineLandrace

TOPIGS 40

T-line

Specific Pure Lines

• Easy• Fast in heat• Economic • Robust• Heat tolerant

13

SIRE LINE PROGRAMTOPIGS International

14

Breeding goal

Three components Efficiency of production (producer demands)

Feed conversion, daily gain, vitality Carcass quality (consumer demands)

Meat and fat distribution in primals Meat quality (consumer demands)

Consumer perception (color, drip loss, IMF)

ProducerConsumer

Optimum

15

Market segments

Meat% -->

Gai

n -->

Lean

RobustEfficient

TOPIGS=

Knowledge+

Knowledge transfer

17

Institute of Pig Genetics Pigbase

Technical Breeding Administration Estimation of Breeding Values

R&D (breeding, nutrition, carcass quality, health and AI)

Information and Communication technology Worldwide Collaboration with Universities/Institutes Testfarm in The Netherlands (180 sows, farrow to

finish)

18

Improvement of the various parts of TOPIGS breeding

program: Improvement data processing Accuracy breeding value estimations Optimisation breeding programs

Major R&D items: Feed efficiency Piglet vitality and mothering ability Development and use of markers en genes Genetic aspects of health and immunity Carcass and meat quality Improvement of AI efficiency and quality

Research programme for TOPIGS

19

TOPIGS sows

Average Top 10% Top 25% No. of farms 951 95 238Av. no. of sows present 430 489 469No. of sows 408930 46455 111622Farm litter index (present sows) 2.39 2.46 2.46Lactation period 24.6 24.0 23.9Weaned / sow / year 27.7 30.8 30.0

Performance data 2009, Netherlands Data from > 11 million piglets

2 farms > 33 weaned / sow / year7 farms > 32 weaned / sow / year100 farms > 30 weaned / sow / year

20

Trends in sow performance

2000 2004 2008 2009No. of farms 485 629 1005 951Av. no. of sows present 251 309 412 430Farm litter index (present sows) 2.35 2.37 2.39 2.39Live born 11.7 12.1 13.1 13.3%Stillborn 7.4 7.4 7.6 7.0Preweaning mortality (%) 12.0 11.6 12.1 12.1Weaned 10.2 10.7 11.4 11.6Weaned / sow / year 24.0 25.2 27.3 27.7

TOPIGS

Genomics

SUNJIN July 15 2009 22

Developments Genome sequence & SNP’s

Genome sequence => very many SNP’s

Technology for large- scale genotyping at low-costs

Pig Genome Sequence

2010

SUNJIN July 15 2009 23

What is a SNP ??SNP = Single-nucleotide

polymorphismA DNA sequence variation

occurring when a single nucleotide — A, T, C, or G — in the genome (or other shared sequence) differs between paired chromosomes

For example, two sequenced DNA fragments from different individuals, AAGCCTA to AAGCTTA, contain a difference in a single nucleotide. In this case we say that there are two alleles : C and T.

SUNJIN July 15 2009 24

Quantitative versus Genomic selection for reproduction

Quantitative selection until today very effective for quantitative traits

New options for PRRS resistanceImpact of genomic selection dependent

upon:1. costs of SNP genotyping (50.000

300.000 SNP’s)2. added value of SNP for accuracy of

breeding value: costs benefitsIn near future combination of Quantative &

Genomic selection expected!!!

25

Balanced breeding !!How to ensure more reproductive sow without problems

for health or vitality of piglets and sow? more piglets born alive, less death more piglets born alive but also weaned high reproductive sows but less culling PERFORMANCE WITH NO HORMONS =

FOOD SAFETY TOPIGS uses selection strategy that takes these

aspects into account

SUNJIN July 15 2009 26

The sow of 2020

There will be further genetic improvement of litter size along balanced breeding

Extra piglet born Extra piglet weaned Dedicated quality improvement along:

wider temperature neutral zone Improvement of vitality/disease resistance application of new genomic tools

Sow 2020: >15 piglets born alive => 14 piglets weaned/litter without intensive human support

27