to reduce antibiotic resistance - usda

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How can we responsibly use antibiotics in animals without compromising food safety and human health, as well as animal health, welfare and productivity? K. Lannoo, J. Vande Ginste, G. Bruggeman Nuscience | Booiebos 5 | 9031 Ghent (Drongen) | Belgium | [email protected] Thanks to a welldefi ned mode of action and proven results in practice it is known that the use of Medium Chain Fatty Acids (MCFA) in animal feeds is one of the preferred solutions all over the world to reduce the use of antibiotics. In the search for safe and innovative solutions Nuscience always puts the benefi t and health of animals and people at the center. With natural alternatives of antibiotics, Nuscience lowers the incidence of antibiotic resistance. Medium Chain Fatty Acids fulfill where antibiotics fall short YOUR KNOWLEDGE PARTNER IN NUTRITION AND HEALTH Medium Chain Fatty Acids to reduce antibiotic resistance Aromabiotic MCFA’s have proven worldwide to be a reliable partner in taking the hurdle towards producing animals on a cost eff ective way without using too much antibiotics. Nuscience all rights reserved - no part of this publication may be reproduced without permission of the copyright owner. Highly antimicrobial Improving gut health bactericidal at stomach level: early barrier very effi cient destabilisation of bacterial cell membrane (cf. SCFA/LCFA) activated (no need for lipase cf. MCT) lower MIC values compared to SCFA broad spectrum: G-, G+, fungi Aromabiotic = synergistic mixtures: more effective good bacteria are not inhibited by MCFA the beneficial microbial ecosystem results in higher villi lengths the increased absorption surface results in a lower feed conversion ratio Reducing pathogen virulence reduced virulence gene (hilA) expression of Salmonella and its invasion at very low MCFA concentrations inhibition of microbial lipase (virulence factor of infectious bacteria) Improving immunity less apoptosis (= programmed cell death) of white blood cells (neutrophils) stronger first defense against infections lower prevalence of both intestinal and non-intestinal disorders Ileum villi length (μm) Control MCFA Piglet 529 582 + 10 % Broiler 644 752 + 17 %

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Page 1: to reduce antibiotic resistance - USDA

How can we responsibly

use antibiotics in animals

without compromising

food safety and human

health, as well as animal health, welfare

and productivity?

K. Lannoo, J. Vande Ginste, G. BruggemanNuscience | Booiebos 5 | 9031 Ghent (Drongen) | Belgium | [email protected]

Thanks to a welldefi ned mode of

action and proven results in practice

it is known that the use of Medium Chain Fatty Acids (MCFA) in animal

feeds is one of the preferred solutions all over the world

to reduce the use of antibiotics.

In the search for safe and innovative

solutions Nuscience always puts the

benefi t and health of animals and

people at the center. With natural

alternatives of antibiotics, Nuscience lowers the

incidence of antibiotic resistance.

Medium Chain Fatty Acids fulfi ll where antibiotics fall short

YOUR KNOWLEDGE PARTNER IN NUTRITION AND HEALTH

Medium Chain Fatty Acids to reduce antibiotic resistance

Aromabiotic MCFA’s have proven worldwide to be a reliable partner in taking the hurdle towardsproducing animals on a cost e� ective way without using too much antibiotics.

Nuscience all rights reserved - no part of this publication may be reproduced without permission of the copyright owner.

Highly antimicrobial Improving gut health

• bactericidal at stomach level: early barrier

• very effi cient destabilisation of bacterial

cell membrane (cf. SCFA/LCFA)

• activated (no need for lipase cf. MCT)

• lower MIC values compared to SCFA

• broad spectrum: G-, G+, fungi

• Aromabiotic = synergistic mixtures: more

eff ective

• good bacteria are not inhibited by MCFA

• the benefi cial microbial ecosystem results

in higher villi lengths

• the increased absorption surface results in a

lower feed conversion ratio

Reducing pathogen virulence

• reduced virulence gene (hilA) expression

of Salmonella and its

invasion at very low

MCFA concentrations

• inhibition of microbial

lipase (virulence factor

of infectious bacteria)

Improving immunity

• less apoptosis (= programmed cell death)

of white blood cells (neutrophils)

• stronger fi rst defense against infections

• lower prevalence

of both intestinal

and non-intestinal

disorders

Ileum villi length (μm)

Control MCFA

Piglet 529 582 + 10 %

Broiler 644 752 + 17 %