tlr signalling pathway-based vaccination
DESCRIPTION
Musketeers Course: Course in Immunology Batch 2012 | Yogyakarta, Indonesia | 2 May 2012.TRANSCRIPT
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Musketeers Course 2012
In Course Presentation
Yogyakarta, May 2th, 2012
Tenri A.W.
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MAJOR CONCEPT
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“The BIG IDEA”
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MAJOR CONCEPT
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WHAT IS DENDRITIC CELL?
DENDRITIC CELL (DC)IS AN ANTIGEN PRESENTING CELL (APC)
DC IS EXPRESSING SEVERAL PATTERN-RECOGNITION RECEPTOR(PRR), INCLUDING TOLL-LIKE RECEPTOR (TLR)
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MAJOR CONCEPT
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ROLE DENDRITIC CELL IN IMMUNITY
DC IN TLR-MEDIATED ANTIGEN RECOGNITION
DC IN ACTIVATION AND MIGRATION
DC IN ANTIGEN PRESENTATION AND ADAPTIVE IMMUNITY ACTIVATION
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ROLE DENDRITIC CELL IN IMMUNITY
DC IN TLR-MEDIATED ANTIGEN RECOGNITION
DC IN ACTIVATION AND MIGRATION
DC IN ANTIGEN PRESENTATION AND ADAPTIVE IMMUNITY ACTIVATION
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TOLL-LIKE RECEPTOR
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TLR, LIGAND, AND ADJUVANT
(DUIN ET AL., 2006)
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ROLE DENDRITIC CELL IN IMMUNITY
DC IN TLR-MEDIATED ANTIGEN RECOGNITION
DC IN ACTIVATION AND MIGRATION
DC IN ANTIGEN PRESENTATION AND ADAPTIVE IMMUNITY ACTIVATION
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TLR SIGNALING PATHWAY
TLR SIGNALING PATHWAY
SIGNALING MOLECULE
PHOSPORILATION CASCADE
TRANSCRIPTION FACTOR
ACTIVATION
CYTOKINE SECRETION
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TLR SIGNALING PATHWAY (CONT)
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TLR SIGNALING INDUCE CCR7 EXPRESSION
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TLR SIGNALING UPREGULATE MHC II AND CO-STIMULATORY MOLECULE
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ROLE DENDRITIC CELL IN IMMUNITY
DC IN TLR-MEDIATED ANTIGEN RECOGNITION
DC IN ACTIVATION AND MIGRATION
DC IN ANTIGEN PRESENTATION AND ADAPTIVE IMMUNITY ACTIVATION
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DC PRESENT ANTIGEN TO NAÏVE T CELL
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DC INDUCE BOTH CD 4 & CD 8T CELL ACTIVATION
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DC INDUCE CD 4 T-CELL DIFFERENTIATION
IN MOST CASE, VIA TLRACTIVATION, INDUCE
DEVELOPING T HELPER 1 RESPONSE
(TRINCHIERY, 2003)
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TH 1 CELL in INTRACELLULAR DEFENSE
TH 1 INDUCE Ig G, NK CELL, MACROPHAGE AND OTHER CELL ACTIVATION IN INTRACELLULARDEFENSE MECHANISM
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MAJOR CONCEPT
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VACCINE IN INFECTIOUS DISEASE
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MYCOBACTERIUM BCG VACCINE
• BCG VACCINE IS USING TLR 2 AND TLR 4 – MYD88 PATHWAY
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TLR 2 - TLR 4 – MYD88 PATHWAY
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VACCINE IN MELANOMA CANCER
• MELANOMA CANCER VACCINE IS DNA VACCINE, USING TLR 9 – MYD88 PATHWAY
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PRINCIPLE OF TLR SIGNALING
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THANK YOU TO THESE GUYS
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MAJOR CONCEPT
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SUMMARY