things you forgot or didn't know about empower … appli empowe… · or didn't know...

©2016 Waters Corporation 1

THINGS YOU FORGOT OR DIDN'T KNOW ABOUT EMPOWER

Le Jeudi 02 février 2017 – Maison de l’Amérique Latine – Paris 7ème Présenté par Alain Barreau


Things you forgot or didn’t know about Empower

Empower 3 is powerful with many features available

In this presentation we show >20 topics that

You might have forgotten,

you might not know,

… or are completely new.

We will try to show all the slides, but

only have 1 hour… so we’ll see how far

we get!

All the options are available in

Empower 3 FR3, our most recent

release.


View Filters [4]

View As Functionality [13]

Result Audit Viewer [16]

Global Project view [25]

Custom Field to check Manual Integration [32]

JP, EP, USP – Signal to Noise [38]

Shifting peaks (relative) [43]

Who is using what System now (Mobile) [55]

Protect Systems and Nodes from being deleted [65]

Protect Parent Projects from being acquired in [69]

Copy Settings to Sub-Projects [72]

Add Peaks and Integration events during Review [74]

ID’s in project view [78]

Copy and Paste [81]

Export to JCAMP [86]

Compare Calibration Curves [88]

Empower Analytics [90]

Current User/System licence status [94]

Walk-Up Interface [96]

Mass Analysis Window [102]

Location Field [107]

MS Peak Tracking [109]

ICH Impurity [114]

Instrument Control [119]

Topics listed


View Filters


View Filter – Just in Time

Any table in Empower can apply a filter – Just in Time

Code for Just in Time is: =#

Example:

Fill information:

Now the projects with ‘Default’ in the name are shown


View Filter – Just in Time

A maximum of three =# options is possible

Fill the Just in Time filter

This gives an overview of the requested projects


View Filter – FAT Settings of Projects

Click Edit View on the Project View, and add the following

8 columns to the view.

Save the View Filter and Apply

Now for each of the projects the FAT settings are shown


View Filter – See latest Result Set

To only see the latest Result Set(s) belonging to corresponding

Sample Set(s), edit the view filter

In the column ‘Result Set ID’ create a Group By Condition

Enter the following Information

The information is filled, then save and apply the filter

Latest Result Set(s) of the Sample Set(s) are shown


View Filter – Last User Login

To see the last user login… after a certain date.

Go to System Audit Trail (1221 records)

Click Edit View to start creating the Filter

Use the View Filter Wizard



Wizard is started

Select the Displayed Columns:

Click Next > until Save View Filter now:

Enter Name and Click Finish



Select in the 1st row ‘Sequence’ and start the Group By function

Fill the Group By Condition, Click OK

Now fill the rest of the filter, save the filter



Upon applying the filter, the change date needs to be entered

Any successful login after this date is displayed (8 records only)


View As Functionality


View As functionality

To see the relation between all data in an Empower project, the

view as functionality is powerful

It works from all tables… including view as Audit Records


View As functionality

There is an extra option available

When you want to go back to the previous view simply select

– View as previous

– View as next

That way you can easily navigate back and forth


Result Audit Viewer


Result Audit Viewer

To review data, the Result Audit Viewer can be used

Open a Result Set into review

Browse to the icons on the top right

Click Result Audit Viewer icon and the viewer is started

All information from the Result Set can be viewed using one

page…

Alter Sample Print

Preview Run Sample Result Audit Viewer


Result History


Result Differences


Results can then be compared

Result ID 1453 and 1463 can be taken into review

Using overlay the slight difference in the integration can be

shown


Result Processing Method


Result Sample Set Method


Result Instrument Method


Result Method Set


Global Project View


Global Project View

In the project view, select 2 (or more) projects

Right Mouse Click, Open

The projects are opened in a Global Project View


Global Project View

Simply activate or deactivate additional projects by clicking the

‘available projects’ button

The following view is shown

Select an additional project and Click Activate

Project is added to the Global Project view


Global Project View - Search

The view filters also work across multiple projects

In this example a filter for Sample Name ‘Sample 6’ is applied

Two different projects and the same Sample Name is shown

With the same sample name selected in the Injection, simply

select View As – Results

– Results of the corresponding Injections in two projects are displayed


Global Project View - Compare

With the same sample name selected in the previous slide we

can simply overlay those results

Select the two results, right mouse click ‘Compare’

Two results will be shown

– Apply the following settings to display

– Properties, Overlay, Overlay in Single Plot

– Properties, Overlay, All Chroms in Overlay


Global Project View - Compare

Both Results (including the integration) are shown in the

overlay plot


Global Project View – Audit Trail

Within the Global Project View it is also possible to see both the

Project and the System Audit Trail

In the Global Projects tree, select Audit Trails


Global Project View – Audit Trail

Within the Global Project View it is also possible to see both the

Project and the System Audit Trail

In the Global Projects tree, select Audit Trails

Now the Audit Trails are shown for System and Project

We can use view filter to search specific actions

Projects Audit Trail

System Audit Trail


Custom Field to check

for Manual Integration


Custom Field to check for Manual Integration

To easily check for Manual Adjustment of Integration, one can

create a Custom Field that checks for these changes using the

Integration Type of the peak

See proposed formula



The proposed formula:

EQ(EQ(Int Type,"BB")+EQ(Int Type,"BV")+EQ(Int Type,"VB")

+EQ(Int Type,"VV")+EQ(Int Type,"EE")+EQ(Int Type,"VE")

+EQ(Int Type,"EV")+EQ(Int Type,"TV")+EQ(Int Type,"VT")

+EQ(Int Type,"TT")+EQ(Int Type,"BS")+EQ(Int Type,"SB")

+EQ(Int Type,"VR")+EQ(Int Type,"RV")+EQ(Int Type,"BG")

+EQ(Int Type,"GB")+EQ(Int Type,"VX")+EQ(Int Type,"XV")

+EQ(Int Type,"Group"),0)

Remember: In case of regulated / controlled work environment, the Custom Fields as shown in this example, do need structural testing and validation prior to its usage



Result in Review



Result in Review

Slight adjustment would

immediate flag the peak

for change in Integration

Type, or addition of peaks



This can be taken a step further by creating a Result Type

Custom Field using the previous Calculation as a Use As ‘Value’

See proposed formula EQ(SUM(IntVal),0)



These Custom Fields can also be brought into Preview


JP, EP, USP – Signal to Noise


JP, EP and USP – Signal to Noise

S/N calculations can be done without the use of a Custom Field

It is calculated as follows

Where H is the height of the peak measured from the peak apex to a baseline extrapolated

Where h is the difference between the largest and smallest noise values observed over a

distance of ≥x times the width at the half-height of the peak if possible, situated equally

around the peak of interest after the injection of a blank

Processing method, Suitability Tab

h

2HS/N

* Depends on the used Pharmacopoeia



Allows determination of noise within a blank injection centered

on the peak region

Allows user to specify a noise segment based on peak width at

half height:

– USP Half Height Multiplier for Noise Region

– EP Half Height Multiplier for Noise Region

– JP Half Height Multiplier for Noise Region

Using more blanks calculates multiple noise values for each

blank injection, then uses the average of the noise value



Half Height Multiplier for EP s/n region = 5

That gives the following regions for the calculation



In the Results tab an extra column is available to see what the

Channel IDs were used for Blank in the S/N calculation

even if more than one blank is used


Shifting peaks (Relative)


Shifting peaks (Relative)

If you have a chromatogram with many peaks, the alignment

might be a lot of work

– Changing mobile phase

– Changing method settings

Empower can help to overcome this


Review window: Method Set Option


Review window: Zoom settings


Processing Method Layout

As an example the last 5 peaks will be used


Processing Method Layout

Manually identify peaks


Manually assign peak 1 to the peak at 27.2 min

Peak 2, Peak 3, Peak 4 and Peak 5 are not effected by the manual assignment of Peak 1


Setup processing method for critical peak (groups)

If peak 1 is modified, you should verify peak 2 too!


Must function in combination with RT Reference

Peak 2 is effected by the manual assignment of Peak 1. Peak name disappears and as peak 2 is a must peak it flags red if the peak is not present / not assigned.


Relative Retention Time (RRT)

RRT = RT of the peak / RT of the RT Reference


Manually assign peaks

Now Peak 2 and Peak 3 are automatically assigned to the correct peaks after the the manual assigment of Peak 1


Conclusion

Avoid repetitive action: by linking the components

Extra check in review if all peaks have been identified by the

use of the ‘must’ function in the processing method


Who is using what system now?

Mobile?


Who is using what system now?

To check the licenses in use, View the System Monitor

Of the two systems available, not one is currently in use

In case no systems are shown, go to View, Options

Select ‘Show All Objects’


Or… one can go use Empower Mobile


Login with normal Empower account


Show your Favorite Systems


Show all Systems


Track Running Injections


And also … Administrative Tasks


Check User Account


Change User Password


Protect Systems and Nodes

from being deleted


Protect Systems and Nodes from being deleted

If you do not want your Systems and Nodes being deleted (e.g.

by mistake) follow these steps

Open the properties of the Node, select Access Tab

Check the Group(s) you Allow Access to



Then change the allowed access to ‘Owner Only’

Click OK, login as other user (= NOT Administrator)



The node can be seen… and the Properties cannot be changed!

Selecting and using the corresponding LC system is possible…

deleting the LC system is not

Reboot of the LAC/E is still allowed and possible


Protect Parent Projects

from being acquired in


Protect Parent Projects from being acquired in

By removing group access from the Parent Projects, these

projects can still be seen, but access is restricted

Colour of the folder is greyish/yellow

Used for Acquisition


No Access (only Admin)




Protect Parent Projects from being acquired in

By removing group access from the Parent Projects, these

projects can still be seen, but access is restricted

Colour of the other folders is bright-yellow







Copy settings from Parent Projects

to Sub-Projects


Copy settings from Parent Projects to Sub-Projects

Changes or settings in a Parent can easily be copied to its

corresponding Sub Projects

Press ‘Copy to Sub-Projects’

– Accessible on General, Access and Processing

Copy to Sub-Projects works on the selected settings… before Clicking OK one can change the settings for the Parent to be different


Add Component Names

and Integration Events

during Review


Add Component Names during review

At first view no peaks are assigned…

Right mouse click on the peak, select Add/Edit Component Name

Enter the component name

Click OK


Add Integration Event during review

Component name is added to the method

and applied to the chromatogram

Right mouse click in the chromatogram, select Add Integration

Event

Add the Integration Event

Click OK


Add Integration Event during review

The integration event is inserted

and applied to the chromatogram


ID’s in Project View



Normal Project view with Default View Filter, would not show

the ID’s…

One could create view filter to always show the ID’s

But in Empower 3 there is a possibility to Persist ID columns in

Project

That way the ID’s will always be visible for all Project Tabs



In Sample Sets

In Result Sets

And also in Injections, Channels, Methods, Results, Peaks,

Fractions, Sign Offs, and Curves


Copy and Paste


Copy and Paste

From Review / Preview / any Tables

From Review, select the chromatogram

Right Mouse Click, Copy

Paste into Word Excel


Copy and Paste

From Preview, select the chromatogram

Right Mouse Click, Copy

Paste in Word Paste in Excel

as picture


Copy and Paste

From Preview, select area to copy to the clipboard

Select the Area, on release it is copied to clipboard

Paste in Word Paste in Excel


Copy and Paste

On a Table, select the information needed

From the menu select File, Copy Table

Paste in Excel


Export to JCAMP


Export to JCAMP

Directly export data* to JCAMP without creation of an export

method

Select the data*

In the menu select Database, Export to JCAMP

Exported data can

be opened using an

external viewer

* Sample Sets, Samples, Channels


Comparing Calibration Curves


Comparing Calibration Curves

Calibration Curves can easily be compared

Select the Curves of Interest

Right Mouse click, and select compare

Easily the difference between the selected curves can be seen


Empower Analytics


Empower Analytics

Empower Analytics offers business owners, system managers,

and laboratory managers insight into business processes, work

flows, and laboratory operations

Empower Analytics consists of various dashboard reports that

present statistical data scanned from the Empower database.

The pre-defined statistical reports provide both summary and

detailed information that can assist you in deciding where and

how to improve laboratory efficiency

In Configure the System

From the menu select Tools

Select Empower Analytics…


Empower Analytics

The first step in your System Overview and Usage


Empower Analytics

Dashboard - Insight in your manual results


Current User/System licence status


Current User/System licence status

To check the licenses in use, View the System Monitor

The active licenses are visible using the Waters License Wizard

Click, Show Licenses

All the activated licenses are listed


Walk-Up Interface


Walk-Up Interface

This interface is designed for high-throughput laboratories where

users walk up to a computer system and run samples using

predetermined methods.

Simplified Interface for easy access and acquisition of Samples

Log in, and select the project and the system.


Walk-Up Interface

Fill the interface. Method, System, Sample Names, Method Set,

Number of Samples, Start Position, Injection Volume, Run Time

give the Sequence Name

Press Run Sample(s)

Place the Samples in the System

Press OK.


Walk-Up Running

The Samples will be injected, system status can be shown.


Walk-Up Method Set

With the Run and Process option set, and when the Method Set

contains a Report Method, the injection is:

– Processed with given Processing Method

– Reported with given Reporting Method

– Printed, if printer is selected!

With the properties in the Walk-Up, the interface can be set to

meet the needs of the groups using the Walk-Up interface

– The slides with the properties are given in the next page


Walk-Up Properties

There are 6 additional properties available in Walk-Up Interface


Mass Analysis Window


Qualitative MS: Mass Analysis

A new “Mass Analysis” window is added to Review which will

allow users to view and analyze the PDA and MS spectral and

chromatographic data from a single result

The window is displayed by clicking on the “Mass Analysis”

button in the Window menu. Window is empty when the current

result does not contain PDA or MS data

Start review from the injection or the PDA channel


Mass Analysis Window: Start from review: Step 1

PDA


Access to properties: modification of the mass analysis view

Fast review: Access to icons/buttons: modification of the mass analysis view

Mass Analysis Window: Setup in properties (right click)


Mass Analysis Window: New window: Step 2

Automatic Extraction of XIC Chromatograms from most intense m/z Peak

PDA & MS Spectra of each Integrated Peak

PDA Chromatogram, Extracted Wavelength

MS XIC for all Integrated Peaks


Location Field


Location Field

With Empower 3 FR3 the location field has been introduced

List of Locations can be maintained in the Default Strings

Then it can be applied to

– Users

– Nodes

– Systems


MS Peak Tracking


Available in Empower 3 FR3

Processing method enhanced

MS Peak Tracking option

Tracking options

– None

– Apex

– Combined

– Number of decimal places

MS Peak Tracking


New fields

– Assigned Mass

– Notes

Automatically

assigns mass

– Using Base Peak (m/z)

– For peaks of the same

mass but different

retention times

Option to manually

assign mass to

override auto

assignment

– Add notes for

manually assigned

mass

MS Peak Tracking


Properties: Peak Labels


Report: Component Summary Table (for unknown peaks!)

Column Type

m/z Retention Time


ICH Impurity

Deviating Thresholds

for Specified Impurities


Deviating Thresholds for Specified Impurities


Summary Slide


Automatically calculate total impurities


Instrument Control


Instrument Control

Empower 3 FR3 has a possibility of controlling 472 Instrument

Modules from 16 Vendors (and growing)


Instrument Control

©2017 Waters Corporation 142 COMPANY CONFIDENTIAL

Solution Overview

Starts from inside Empower, no additional login required.

Interacts with an Empower Sample Set Method

– Map weights to sample and component fields.

Import weights to existing and running sample set methods

Keeps a complete audit trail of all weights acquired for FAT projects

Import weights from balances directly into Empower


Mapping weights to a sample set method


Client PC

Basic Solution Architecture

Empower

Direct Cable Connection

Ethernet Conversion (if required by balance)

Sample Weight Importer

Empower Toolkit

SDS


Advanced Solution Architecture

Ethernet Conversion (if required by balance)

Tibbo Device to connecting a balance to network http://tibbo.com/soi/tdst.html

Empower Network


Rencontrer nos experts

Logiciels Instrumentations Consommables Service

Solutions informatiques

Gammes Colonnes Contrats

Applications Préparation d’échantillons

SAV

Flacons Formation

Salle actuelle Salon Miranda (RdC près du vestiaire)

Aurélie Chambon Taraneh Kargar-Grisel Gilles Jaouen Reda Zarrou

Alain Barreau Isabelle Jarecki Myriam Harmouche Sébastien Lahalle

Damien Martin Bruno Contrastin

things you forgot or didn't know about empower … appli empowe… · or didn't know...

Documents