the south african bone marrow registry...2020/04/09 · wedding which took place in november 2012...
TRANSCRIPT
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The South African Bone Marrow Registry
Helping the People of Africa
E D du Toit, T Schlaphoff, V Borrill
South African Bone Marrow Registry, Cape Town
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History & Functions Established 1991
First matched unrelated donor (MUD) transplant 1997
Hub Centre for SA – liaison between registries worldwide
Provides MUD’s for haematopoietic stem cell (HSC) transplantation:
SA Patients
Patients referred from other African countries
Worldwide
Donor recruitment:
The Sunflower Fund
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History & Functions, cont’d
Member of WMDA
Guidelines for donor care and collection & transfer of products
BMDW Participant
Universal search tool
to identify potential
donors worldwide
SABMR database:
±67 000 donors
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Responsibilities of the SABMR as Hub Centre
Link between the patient’s
doctor and donor registry.
Responsible for the transport of stem cells from donor to patient.
Responsible for well-being of own donors: 5 year post-donation
follow-up.
Responsible for payments to local service providers and international registries.
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HLA typing
Matching is required for ALL organ transplants
For bone marrow transplantation the patient and donor must be like identical twins.
Therefore molecular matching essential.
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Patients Referred
Preliminary Search:
>1400 since 1991
Not all from South Africa
Search progression: Search Activation: 50%
Donor Identification: 30%
HSC Transplantation: 25%
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Patients Transplanted
Adults 277
Children 57
SA citizens 324
Other African Countries 10
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Patients Receiving MUD BMT
in South Africa: 1997 - 2013
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0 10 20 30 40 50 60 70 80
Platelet Disorders
Polycythaemia Vera
Other Anaemias
Chronic Lymphocytic Leukaemia
Juvenile Myelomonocytic Leukaemia
Paroxysmal Nocturnal Haematuria
Immunodeficiency Conditions
Inherited Metabolic Abnormalities
Severe Combined Immunodeficiency
Other Leukaemias
Hodgkin's Lymphoma
Myelofibrosis
Fanconi Anaemia
Multiple Myeloma
Severe Aplastic Anaemia
Myelodysplastic Syndrome
Chronic Myeloid Leukaemia
Non-Hodgkin's lymphoma
Acute Lymphocytic Leukaemia
Acute Myeloid Leukaemia
Diagnoses
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Unrelated HSC Products for Patients Transplanted in SA
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Countries of origin of donors for South African Patients
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Patients from other African countries receiving MUD BMT in South Africa
Angola (1)
Ethiopia (1)
Kenya (1)
Namibia (4)
Sierra Leone (1)
Somalia (1)
Uganda (1)
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The donors for these patients came from:
Italy (1)
Israel (1)
Germany (2)
USA-NMDP (4)
USA-GOL (1)
South Africa (1)
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International Collaboration
SABMR donors for International patients: Austria (1) France (1) Germany (2) Italy (2) Portugal (1) Sweden (1)* The Netherlands (1) United Kingdom (3) United States of America (5)
HLA-A*43:01 → Sweden
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Case Report: SABMR helps Nigerian sibling donor
Patient in USA – (male/25/ALL)
Sister a match, but lived in Nigeria – USA visa refused
SABMR approached by NMDP to help
Managed as if an unrelated
donor
Donor travelled to SA to donate, accompanied by her father
From arrival in SA for medical examination, to PBSC collection – 11 days
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Keeping in touch after the donation - donor Follow-up by SABMR
SABMR was delighted to receive photographs of the donor’s wedding which took place in November 2012
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Helping hand to Nigerian registry SABMR approached
by DKMS in America following donor drive in Nigeria for law student studying in USA
Donors could not be listed in USA
SABMR agreed to temporarily host donors
Donors given unique identifier: ZA-NGA
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Seun Adebiyi
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Helping hand to Nigerian registry, cont’d
Bone Marrow Registry Nigeria (BMRN) establishes own infrastructure in 2012
Donors transferred from SABMR to BMRN and listed separately in BMDW:
347 donors,
March 2014
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From left: Dr. Sunday Ocheni, Dr. Anthea Nwandu of the University of Maryland, Seun Adebiyi, Professor Ifeoma Okoye, and Liana Schapiro celebrate a successful launch!
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Unrelated Haematopoietic Stem Cell Transplantation in Africa:
Considerations
Skills & Facilities to offer BMT
Unrelated Donor Registry –
? Each country
? Regional
Resources –
Private
State
Sponsored
Collaboration –
International
Within Africa 19