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Supporting information
Chloroform as carbon monoxide source in Palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a] pyridines
P. R. Nitha,a,b Manu M. Joseph,a Greeshma Gopalan,a,b K. K. Maiti,*a,b K. V. Radhakrishnan,*a,b Parthasarathi Das*c
a.National Institute for Interdisciplinary Science and Technology (CSIR)
Thiruvananhapuram-19 (India)b.Academy of Scientific and Innovative Research (AcSIR) Thiruvananthapuram-19
(India)c.Department of Applied Chemistry, Indian Institute of Technology (ISM)
Dhanbad- 826004
* Corresponding Author: Parthasarathi Das
E-mail: [email protected]
Table of contents
1. Biological Data of compounds 3j, 3m, 3p, 3r, 3q and 3c....................... 2
2. Copies of 1H and 13C NMR spectra of compounds 3a-3u........................5
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry.This journal is © The Royal Society of Chemistry 2018
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2
Cytotoxicity evaluation of compounds at different concentrations on Hela and
WI-38 cell lines
3j
3m
Page 5
5
1H and 13C NMR of 3a (CDCl3)
N
N N
O
3a
N
N N
O
3a
Page 6
6
1H and 13C NMRof 3b (CDCl3)
N
N N
O
3b
N
N N
O
3b
Page 7
7
1H and 13C NMRof 3c (CDCl3)
N
N N
O
O
3c
N
N N
O
O
3c
Page 8
8
1H and 13C NMRof 3d (CDCl3)
N
N N
N
O
OO
3d
N
N N
N
O
OO
3d
Page 9
9
1H and 13C NMRof 3e (CDCl3)
N
N N
N
O
3e
N
N N
N
O
3e
Page 10
10
1H and 13C NMRof 3f (CDCl3)
N
N O
HN 8
3f
N
N O
HN 8
3f
Page 11
11
1H and 13C NMRof 3g (CDCl3)
N
N HN
O
3g
N
N HN
O
3g
Page 12
12
1H and 13C NMRof 3h (CDCl3)
N
N
O
NH
3h
N
N
O
NH
3h
Page 13
13
1H and 13C NMRof 3i (CDCl3)
N
N
HN
O
3i
N
N
HN
O
3i
Page 14
14
1H and 13C NMRof 3j (CDCl3)
N
N
HN
NH
O
3j
N
N
HN
NH
O
3j
Page 15
15
1H and 13C NMRof 3k (CDCl3)
N
N NH
O
3k
N
N NH
O
3k
Page 16
16
1H and 13C NMRof 3l (CDCl3)
N
N NH
O
OMe
3l
N
N NH
O
OMe
3l
Page 17
17
1H and 13C NMRof 3m (CDCl3)
N
N
HN
O
HO3m
N
N
HN
O
HO3m
Page 18
18
1H and 13C NMRof 3n (CDCl3)
N
N
O
HNOH
3n
N
N
O
HNOH
3n
Page 19
19
1H and 13C NMRof 3o (CDCl3)
N
N NH
O
OMe
3o
N
N NH
O
OMe
3o
Page 20
20
1H and 13C NMRof 3p (CDCl3)
N
N N
O
F
3p
N
N N
O
F3p
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21
1H and 13C NMRof 3q (CDCl3)
N
N N
O
OMeMeOOMe 3q
N
N N
O
OMeMeOOMe
3q
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22
1H and 13C NMRof 3r (CDCl3)
N
N N
O
CN
3r
N
N N
O
CN
3r
Page 23
23
.
1H and 13C NMRof 3s (CDCl3)
N
N N
O
3s
N
N N
O
3s
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24
1H and 13C NMRof 3t (CDCl3)
N
N
O
N
3t
N
N
O
N
3t
Page 25
25
1H and 13C NMRof 3u (CDCl3)
N
N
O
N
3u
N
N
O
N
3u