Paul Connolly Business Manager Liquid Chromatography

Product Launch Training

New Roc™ LC Columns The Reliable Cornerstonefor Your LC Lab

Objectives

• What is Roc™• The competition• Where to position Roc™• Product Offering• Collateral

What is Roc™

• Roc™ is a Conventional HPLC Column Line• Roc™ is a quality, rugged, reproducible HPLC

column.• Roc™ is designed and built for everyday

analytical needs.• Roc™ provides solid performance and

exceptional value.

Product Offering

• 100, 150, and 250 mm Lengths• 3.0 and 4.6 mm IDs

Product Offering

• High Purity Type B Silica• 3 and 5µm• Low surface activity• Low metals content

Product Offering

5 Phases– C18 – C8 – Phenyl-Hexyl – Cyano– Silica

New for Restek

Product Offering

Product Offering

• 10 x 4 mm, 5µm guard cartridge

• New Roc™ Guard Holder matches Roc™ columns

Roc™ Pricing Structure

$0.00

$100.00

$200.00

$300.00

$400.00

$500.00

$600.00

US List Pricing

Roc™ Ultra Pinnacle II

3µm, 100 x 3.0 mm

5µm, 250 x 4.6 mm

3 packGuards

Roc™ Competitively Priced

Major Column Competitors Complementary Guard Cartridges

$0 $100 $200 $300 $400 $500 $600 $700 $800

Waters Symmetry

Phenomenex Luna

Thermo Hypersil

Agilent Zorbax

Restek Roc™

$720

$705

$586

$569

$325

LC Columns US List Price*

$0 $20 $40 $60 $80 $100 $120 $140 $160

Synnetry C18 Sentry Guard

Phenomenex Security Guard

Thermo Hypersil

Agilent Zorbax

Restek Roc™

$118

$40

$144

$52

$40

LC Guard Cartridges US List Price (per cartridge)**

*US List for a 150 x 4.6 mm 5um C18 Column**US List for the recommended C18 Guard. Part List Price/quantity per pack shown

Roc™ Rugged for Long Life

90

92

94

96

98

100

102

104

0 250 500 750 1000

% E

ffici

ency

Number of Injections

% Efficiency vs # of Injections RocTM C18 5µm @ 375 bar

100x4.6mm

150x4.6mm

250x4.6mm

100x3.0mm

150x3.0mm

250x3.0mm

Roc™ Exceptional ReproducibilityRoc™ C18 5um, 150 x 4.6 mm columns from multiple lotsReverse Phase Test

Roc™ Cyano 3um, 100 x 3.0mm columns from multiple lotsNormal Phase Test

Roc™ Guard Cartridge Column Protection

Roc™ Guard Column Cartridge and Holder

Little To No change in Chromatography with Guard

Change in Retention = 0Change in Asymmetry = - 0.026Change in Efficiency = + 6,072 N/m

Roc™ PackagingMore of what you need, and less of what you don’t.

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Roc™ PackagingRemarkable reduction in packaging means less shipping cost

and less storage space needed

250mm column

Traditional packaging15.75” x 5” x 1.75” = 137.81 cubic inches

Roc™ packaging12” x 1.125” x 1.125” = 18.75 cubic inches

86.4% reduced volume!

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Roc™ PackagingRemarkable reduction in packaging means less shipping cost

and less storage space needed

100mm column

Traditional packaging9.5” x 3.625” x 1.75” = 60.3 cubic inches

Roc™ packaging6” x 1.125” x 1.125” = 7.6 cubic inches

87.4% reduced volume!

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Roc™ PackagingSecure, rugged packaging means confidence.

Columns returned in intact package after rigorous shipping studies:

• Cross country ground (United States) and international air shipping

• Tested in both an envelope and an outer box

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Roc™ PackagingSecure, rugged packaging means confidence.

Columns safely and firmly suspended in tube with locking tabs.

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Roc™ PackagingSecure, rugged packaging means confidence.

Shrink-band seal:

• Tightly secures cap

• Allows obvious tamper evidence

• Perforated for hassle-free removal

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Roc™ PackagingOnline Certificates of Analysis means less waste.

Lost copy? Need duplicate copies? Need it now? Problems solved!

“For your LC certificate of analysis go to: www.restek.com/documentation” clearly printed on every column package insert.

• Packaging process is streamlined, less printing.• Save customer time and worry – certs always immediately available.• Less is more!

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Roc™ PackagingOnline Certificates of Analysis means less waste.

• Visit www.restek.com/documentation• Enter catalog and serial numbers• Click pdf link in “Certifications” column• View, save, or print certificate

22 / 9

Roc™ PackagingOnline Certificates of Analysis means less waste.

23 / 9

Roc™ Guard Column Cartridge Packaging

Roc™ Guard Holder Packaging

Instruments

• 400 bar• Highest system volume• $

• 600 bar• Moderate system volume• $$

• 1000 bar• Lowest system volume• $$$

Conventional HPLC UHPLCIntermediate HPLC

The main differences are cost, operating pressures, and system volumes

Roc™ Target Customers• HPLC users who are running standardized and/or

Compendia methodology

• Environmentally or Economically conscious

• Looking for a rugged reproducible HPLC column for routine testing

Roc™ Target CustomersL1 C18 4039 68%L7 C8 930 16%L3 Silica 303 5%L11 Phenyl 300 5%L10 Cyano 237 4%L8 Amino 119 2%

5928

USP Monographs, Breakdown by Phase

98% of USP Methods

Roc™ Target CustomersExample USP Monograph for Caffeine:

Recommendation: Roc™ C18, 5µm, 150 x 4.6 mm, Part # 9534565

Roc™ Target Customers• Nutritional Manufacturers and Labs• Generic Pharmaceutical Manufacturers

• Environmental Labs• Food Labs

CMC Testing: Chemistry, Manufacturing and Controls. From early characterization, raw material and compendia testing; formulation and method development through commercial release and stability.

Business/Customer Opportunity

Raptor™ [Premium]– Clinical– Diagnostics– Innovation/Technology

Conscious– Reliability– Speed & Throughput– LC-MS/MS

Roc™ [HPLC]– Pharma/CMC– Environmental– Emerging Markets– Price Conscious– Reliability– HPLC

Product Offering/Rationale

LC-MS/MS Market

30-100mmx

2.1mm

HPLC Market100-250mm

x 3.0-4.6mm

Raptor

Roc™

Premium PhasesBiphenyl, C18, FluoroPhenyl, Polar Amplified

Standard PhasesC18, C8, P-H, CN, Si

3µm 5µm

5µm2.7µm

SPP

FPP

Roc™ Complete Product Offering

Roc™ C18 HPLC Columns (USP L1)

Roc™ Phenyl-Hexyl HPLC Columns (USP L11)Roc™ C8 HPLC Columns (USP L7)

Roc™ Cyano HPLC Columns (USP L10)Roc™ Silica HPLC Columns (USP L3)

Roc™ LC Guard Column Cartridges

Roc™ LC Guard Column Holder

Replacement PEEK Ferrules

Buy in Bulk and SaveList 30% Discount

$325 $227.50

1 column

5µm x 150 x 4.6 mm Brazil China Germany India

Economy Shipping $53.56 $47.74 $42.28 $53.41

Duty Rate 14% 0% 0% 7.5%

Landed Cost $312.91 $275.24 $269.78 $297.97

5 columns5µm x 150 x 4.6 mm Brazil China Germany IndiaEconomy Shipping $53.56 $47.74 $42.28 $53.41

Duty Rate 14% 0% 0% 7.5%Landed Cost $1,350.31 $1,185.24 $1,179.78 $1,276.22

Landed cost/column $270.06 $237.05 $235.96 $255.24Savings/column $42.85 $38.19 $33.82 $42.73

10 columns

5µm x 150 x 4.6 mm Brazil China Germany India

Economy Shipping $53.56 $47.74 $42.28 $53.41

Duty Rate 14% 0% 0% 7.5%

Landed Cost $2,647.06 $2,322.74 $2,317.28 $2,499.04Landed cost/column $264.71 $232.27 $231.73 $249.90

Savings/column $48.20 $42.97 $38.05 $48.07

9534565Roc™ C18

5µm, 150 x 4.6 mmUS List: $325

Improve your Margin by taking stock of Roc™ Columns

Collateral

• Roc™ Landing Page (www.Restek.com/Roc)• Roc™ Sales Sheet (POD) : GNSS2332-UNV• Press Release : GNPR2330-UNV• E-Blast : GNEB2331-UNV

On www.restek.com• Web Ad • What’s New• Social Media• Product Pages

www.restek.com/roc

The Reliable CornerstoneFor your LC Lab

Roc™ Sales Sheet : GNSS2332-UNV

The Reliable CornerstoneFor your LC Lab

Questions can be directed to your Restek Sales Manager or to Paul Connolly, Business Manager, Liquid Chromatography (paul.connolly@restek.com)

Thank you