the psiho project photoneutron source in hospital financially supported by: national institute for...
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The PSIHO Project Photoneutron Source In HOspital
Financially supported by:
National Institute for Nuclear Physics
•Ministery of Industry, Research and University
•Fondazione CRT Torino
In-hospital installation of Dedicated Linac &New PhoNeS photoconverter
Gianrossano GIANNINI([email protected]) Physics Dept. Trieste University and INFN
Via Valerio 2, Trieste, 34127, Italy
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PhoNeS Bianco prototype
50% boron carbide slabs
50% Epoxy resin slabs, thickness 2 mm
Lead slabs, thickness 1 mm
Graphite:
- 2 horizontal blocks, 15 x 30 x 60 cm3
- 2 vertical blocks, 15 x 30 x 30 cm3
GR
AP
HIT
E GR
AP
HIT
ELEAD
D2O
POLYETHILENE
Closed cavity configuration
• Two carbon fibre boxes filled with heavy water and a polyethylene slab to close
Thermal neutron field of suitable intensity and energy spectral distribution for biological samples irradiation
60 cm
60 cm
MCNP-GN simulation
Cavity: 20 x 20 x 10 cm3At present
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Universita’ degli Studi di Torino II Facolta’ di Medicina e ChirurgiaASO San Luigi Gonzaga Orbassano
TorinoOrbassano –Torino (Italy) The hospital was
funded in 1818.
Since 1970 is situated in the new location.
It is leader in the treatment of lung diseases.
BUNKER
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Campioni di tessuti polmonari umani, in seguito a rimozione chirurgica presso l’ospedale S. Luigi Orbassano di Torino
dopo perfusione con boron-phenyl-alanine arricchita in 10B (10BPA) per 2 ore,
Campioni ~10mm di spessore e ~ 1cm2 di area preparati su lastrine di CR-39
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Convertitore fotoneutronico PhoNeS montato presso il linac Elekta SLIT 25 MV dell’Ospedale Le Molinette di Torino
Campioni biologici su CR-39 due strati (37 x 13 x 1 mm3) esposti a neutroni termici nella cavita’ di PhoNeS
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Electa SL2525 MV
70000 M.U.@400 M.U./min104 s ~ 3 hours
PHONES~1011 n/cm2
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Histological samples on CR-39 detectors and corresponding image of samples after irradiation.
CR-39 ANALYSIS
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• ImageJ.• Cinema 4D.• Surfer8.
Image processing
green>20ppmblue>40ppm
orange>60ppmred>80ppm
Color-densitometry
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Image-Pro Plus © Microscopic Image Automated Analysis
for hole area study and counting
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DETERMINAZIONE DEL BORO EMATICO A VARI TEMPI DOPO PERFUSIONE CON BPA
0.0
20.0
40.0
60.0
80.0
100.0
120.0
140.0
0 30 60 90 120 150 180 210 240
tempo, min
ug
/ m
L &
in
ten
sità
pix
el ICP-MS @ PAVIACR39 @ TRIESTESi Det @ COMO
Time, min
DETERMINATION OF BORON CONCENTRATION AT VARIOUS TIMES AFTER PERFUSION WITH 10BPA
μg
/ml
(Pav
ia)
or p
pm
(T
riest
e/C
omo)
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Analisi di campioni biologici da tessuto umano trattato con perfusione ex-vivo con BPA per studiare diversi tipi di patologie tumorali (in particolare il mesotelioma) seguendo le indicazioni degli oncologi.
Si prevede che nei prossimi decenni (2015) il mesotelioma polmonare (neoplasia della pleura polmonare) diventi uno dei tumori con il più alto tasso di incidenza a causa dell’uso industriale e civile dell’amianto negli ultimi 20-30 anni. QUESTO ASPETTO E’ DI GRANDE INTERESSE PER LA COMPONENTE OSPEDALIERA.
In Regione Piemonte si prevede un numero rilevante di pazienti affetti da tale patologia per la presenza di impianti industriali che utilizzavano o producevano eternit (“Eternit” di Casale Monferrato), e come dimostrato anche da recenti fatti di cronaca (Chivasso (TO), 22/07/08)
Le regioni più colpite dal mesotelioma, il cosidetto “mal d’amianto”,sono: Liguria, Friuli Venezia Giulia, Piemonte e Lombardia
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• Possibility of full time use of the LINAC overcoming the restriction imposed by radiotherapy departments for the use of clinical accelerators:
– Time restriction (following the patients timetable)– Impossibility to modify the machine parameters
Dedicated Linac: advantages & goals
(,n) treashold energy regionNeutron photoproduction
+1.5 times higher
• For photoneutron production it is not necessary to have an optimized gamma beam
• Removing filters (flattening and hardening filters) from the linac gantry • Improving the linac duty cycle, (increasing beam current, repetiton rate, pulse duration, etc.)
to obtain
• higher gamma fluence rate• higher neutron photoproduction
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• e-Linac Elekta 25 MeV max dose rate 400 UM/min
• PhoNeS Bianco (weight ~ 400 kg – assembling time ~ 1.5 ore)
• Thermal neutron fluence rate ~ 1E7 n cm-2s-1
• Biologiacl samples: primary lung carcinoma
UM total: 70000; Total fluence: ~ 1E11 ncm-2; Irradiation Time: ~ 3 hrs
Experimental set-up for biological trials
BIOLOGICAL SAMPLES INSIDE THE CAVITY
The irradiation has been carried out at Radiotherapy Department of San Giovanni Battista Molinette Hospital (Turin, Italy)
At present
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PhoNeS Optimized Prototype
GRAPHITE
LEAD
HEAVY WATER
POLYETHILENE
IRRADIATION CAVITY
•An optimized geometrical configuration of the various components has been designed.
•The high-Z core for neutron production and the low-Z moderating structures are suitably shaped.
FUTURE
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Neutron photoproduction 15 times higher
by using PhoNeS optimized prototype and dedicated
LINAC
PhoNeS Optimized
PhoNeS Bianco
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PhoNeS Bianco vs PhoNeS Optimized Prototype
PhoNeS Prototypes Neutron Beam Parameter
PhoNeS Bianco PhoNeS Optimized
Thermal Neutron Fluence
Rate
1.01E7 cm-2s-1
(78%)
1.50E8 cm-2s-1
(73%)
Epithermal Neutron Fluence
Rate
2.18E6 cm-2s-1
(18%)
4.08E7 cm-2s-1
(20%)
FastNeutron Fluence
Rate
5.88E5 cm-2s-1
(4%)
1.43E7 cm-2s-1
(7%)
Biological samples
irradiation time
3 hrs(1E11 ncm-2)
12 min(1E11 ncm-2)
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BUNKER INSTALLATION SITE
• ASU San Luigi Gonzaga Orbassano (TO)
Already built and actually not used for radiotherapy. Proposed by San Luigi Gonzaga hospital for PhoNeS BNCT studies
CORRIDOR
CO
NT
RO
L R
OO
M
BUNKER
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Conclusion
• A dedicated LINAC and an optimized PhoNeS prototype could provide an increase of neutron photoproduction of:
• about +1.5 times by removing filters (flattening and hardening)• about +4 times by increasing LINAC beam power• about +2.5 times by using PhoNeS optimized prototype• for a total of about 15 times higher in neutron photoproduction
12 min. total thermal neutron fluence rate of 1E11 cm-2
FIRST IN-HOSPITAL NEUTRON SOURCE FOR BNCT RESEARCH!
(available to the worldwide BNCT scientific community)
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Institutes
• INFN Torino• INFN Trieste• Università degli Studi di
Torino• Politecnico di Torino• Università degli Studi di
Trieste• Università dell’ Insubria di
Como• Università degli Studi di Pavia• Universita’ FedericoII di
Napoli• Universita’ La Cattolica di
Roma
Collaboration
Hospitals
•IRCC Candiolo (Torino)•ASO Mauriziano Umberto I° (Torino)•AOU San Luigi – Orbassano (Torino)•AOU San Giovanni Battista (Torino)•ASO Sant’Anna (Como)•Ospedale Maggiore (Trieste)•ST. JOHANNS HOSPITAL Salisburgo
IndustriesSORDINA s.p.a. Saonara (PD)
Elekta Company
Tecnologie Avanzate s.r.l. ( Torino)
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TRIESTE: Gianrossano Giannini (100%, Resp.Loc., P.O.), ErikVallazza (20%, P.R.), Massimo Vascotto (20%, D.S.S.),
A.Zanini (Resp.Naz., INFN Torino)
• Richieste finanziarie locali a Ts (kE)
MI:9.0 ME:4.0 MC:6.0 TR:2.0 CA:8.0 TOT:29
• Richieste servizi: Officina Meccanica :S.Reia (2m/u), D.Iugovaz (1m/u); Laboratorio Elettronica e Rivelatori : M.Bari (1m/u)
PSIHO Photoneutron Source In HOspital
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Torino-Trieste-Como project
• Linac accelerators already exist in hospital radiotherapy departments
• well-known technology accepted by patients and medical staff
• Projects PHONES, NOE, NOE2 supported by INFN from 2005 to 2010
• Encouraging results obtained during:
•feasibility study, •first prototype test (PhoNeS Bianco), •first biological trials on human lungs
• Great interest by San Luigi Gonzaga hospital (Orbassano, Torino) for BNCT study on lung tumors (adenocarcinoma, mesothelioma)
• Availability by Elekta company in order to provide a decommisioned 18 MV Linac and to adapte for BNCT studies
• Possibility of installation in radiotheraoy dept. of San Luigi Gonzaga hospital with collaboration and assistance of radiotherapy staff.• Applications in BNCT:
•analysis of 10B uptake in different lung cancer•study of the behaviour and efficacy of different 10B carriers
• Multidisciplinary applications cultural heritage studies, neutron radiography, etc.
In-Hospital installation of Dedicated Linac
&PhoNeS Optimized PrototypePrevious results