The organization of the nervous system Structure of the human cerebral cortex Sensory map Structure of the human cerebral cortex Motor map Neuromuscular junction How to manipulate it ? Curare ACh-ase inhibitors Myastenia gravis Botulinum toxin Pesticides Parkinsons disease Basal ganglia Parkinsons disease Basal ganglia Parkinsons disease Most common symptoms Parkinsons disease Most common symptoms Shaking (tremor) at Rest Stiffness (rigidity) Slow Movement (bradykinesia) Balance Problems (postural instability) Multiple sclerosis Myelin Multiple sclerosis Demyelination Multiple sclerosis Progression Multiple sclerosis Progression AML Amyotrophic Lateral Sclerosis (Lou Gherig disease) AML Amyotrophic Lateral Sclerosis (Lou Gherig disease) Mutation or defect in neuronal SOD activity Excess oxidative stress to neuronal mitochondria Degeneration of motor neurons Paralysis muscular atrophy Exacerbated by glutamate neurotransmitter activity