the open phacts discovery platform open phacts for academia
TRANSCRIPT
![Page 1: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/1.jpg)
The Open PHACTS Discovery Platform
Open PHACTS for Academia
![Page 2: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/2.jpg)
http://www.rsc.org/chemistryworld/Issues/2009/January/PharmaRefocusesOnThePatentCliff.asp
PwC - Pharma 2020 – Which Path will you take
Patent Expiry
Generic Competition
Cost Containment
Improve R&D
Productivity
![Page 3: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/3.jpg)
Public Domain Drug Discovery Data:Pharma are accessing, processing, storing & re-processing
LiteraturePubChem
GenbankPatents
DatabasesDownloads
Data Integration Data AnalysisFirewalled Databases
![Page 4: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/4.jpg)
We are all doing this many times……
GS
K Pfizer A
straZeneca
RocheN
ovartis
Merck-S
erono
![Page 5: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/5.jpg)
Over the last decade
• Data has become more open• Data has become better represented (Standards)• Major providers are becoming more organised (NCBI, EBI, FDA)
BUT
Integration across sources, and across providers is still a gap
![Page 6: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/6.jpg)
Pre-competitive Informatics:Pharma are all accessing, processing, storing & re-processing external research data
LiteraturePubChem
GenbankPatents
DatabasesDownloads
Data Integration Data AnalysisFirewalled Databases
Repeat @ each
companyx
Lowering industry firewalls: pre-competitive informatics in drug discovery Nature Reviews Drug Discovery (2009) 8, 701-708 doi:10.1038/nrd2944
![Page 7: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/7.jpg)
• EC funded public-private partnership for pharmaceutical research
• Focus on key problems– Efficacy, Safety,
Education & Training, Knowledge Management
The Innovative Medicines Initiative
The Open PHACTS Project• Create a semantic integration hub (“Open
Pharmacological Space”)…• Runs 2011-2014, ENSO till 2016• Deliver services to support on-going drug discovery
programs in pharma and public domain• Leading academics in semantics, pharmacology
and informatics, driven by solid industry business requirements
• 31 academic partners, 9 pharmaceutical companies, 3 software SMEs
• Work split into clusters:• Technical Build• Scientific Drive• Community & Sustainability
![Page 8: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/8.jpg)
Open PHACTS Mission:
Integrate Multiple Research Biomedical Data Resources
Into A Single Open & FreeAccess Point
![Page 9: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/9.jpg)
The Real Mission
Starting from a relatively blank canvas, build a pharmacology-centric integration system that’s as good as, or better than, that which pharma already have after decades of working in this space….
…with a distributed set of people who have never met and many of which have not worked on drug-discovery previously…
…using an emerging, actively evolving technology…
…with an architecture that fulfils the need of both public and private users…
…in just over a couple of years…
…whilst doing some research at the same time
![Page 10: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/10.jpg)
ChEMBL DrugBankGene
OntologyWikipathways
UniProt
ChemSpider
UMLS
ConceptWiki
ChEBI
TrialTrove
GVKBio
GeneGo
TR Integrity
“Find me compounds that inhibit targets in NFkB pathway assayed in only functional assays with a potency <1 μM”
“What is the selectivity profile of known p38 inhibitors?”
“Let me compare MW, logP and PSA for known oxidoreductase inhibitors”
![Page 11: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/11.jpg)
Number sum Nr of 1 Question
15 12 9 All oxidoreductase inhibitors active <100nM in both human and mouse
18 14 8Given compound X, what is its predicted secondary pharmacology? What are the on and off,target safety concerns for a compound? What is the evidence and how reliable is that evidence (journal impact factor, KOL) for findings associated with a compound?
24 13 8Given a target find me all actives against that target. Find/predict polypharmacology of actives. Determine ADMET profile of actives.
32 13 8 For a given interaction profile, give me compounds similar to it.
37 13 8The current Factor Xa lead series is characterised by substructure X. Retrieve all bioactivity data in serine protease assays for molecules that contain substructure X.
38 13 8Retrieve all experimental and clinical data for a given list of compounds defined by their chemical structure (with options to match stereochemistry or not).
41 13 8
A project is considering Protein Kinase C Alpha (PRKCA) as a target. What are all the compounds known to modulate the target directly? What are the compounds that may modulate the target directly? i.e. return all cmpds active in assays where the resolution is at least at the level of the target family (i.e. PKC) both from structured assay databases and the literature.
44 13 8 Give me all active compounds on a given target with the relevant assay data
46 13 8Give me the compound(s) which hit most specifically the multiple targets in a given pathway (disease)
59 14 8 Identify all known protein-protein interaction inhibitors
Business Question Driven Approach
![Page 12: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/12.jpg)
THE OPEN PHACTS DISCOVERY PLATFORM
![Page 13: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/13.jpg)
http://dx.doi.org/10.1016/j.websem.2014.03.003
The Open PHACTS Discovery Platform
• Cloud-Based “Production” Level System. Secure & Private
• Guided By Business Questions
• Uses Semantic Web Technology But provides a simple REST-ful API for everyone else
http://dx.doi.org/10.1016/j.drudis.2013.05.008
![Page 14: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/14.jpg)
Basic Semantic web standards– SPARQL 1.1, RDF(S), SKOS
Dataset descriptions– Vocabulary of Interlinked Datasets (VoID)– VoID linkset descriptions
QUDT Quantities, Units, Dimensions and TypesProvenance– W3C PROV, PAV, Nanopublications
BioPortal, ConceptWiki, ChEMBL, identifiers.org, Uniprot, ChemSpider
http://imgs.xkcd.com/comics/standards.png
![Page 15: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/15.jpg)
Are These Two Molecules The Same(*)
*Really: Is it sensible to combine data associated with these two molecules?
Yeah
No way!
![Page 16: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/16.jpg)
Chose John Wilbanks as consultant
A framework built around STANDARD well-understood Creative Commons licences – and how they interoperate
Deal with the problems by:
Interoperable licences
Appropriate terms
Declare expectations to users and
data publishers
One size won‘t fit all requirements
Data Licensing Solution
![Page 17: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/17.jpg)
![Page 18: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/18.jpg)
Kick-Starting SustainabilityC
olla
bo
rati
on
Gra
nts
Ind
ust
ry
Open PHACTSA
PI U
sers
Apps
API
![Page 19: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/19.jpg)
Open PHACTS Associate Partner Community
![Page 20: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/20.jpg)
Development partnershipsInfluence on API developments
Opportunities to demo ideas & use cases to core team
Need MoU and annexe
Associated partnersOrganisations, most will join here
Support, information
Exchange of ideas, data, technology
Opportunities to demo at community webinars
Need MoU
Associated partners
Development partnerships
Consortium
MoU
+Annexe
Consortium31 current members
Leveraging Our Community
![Page 21: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/21.jpg)
Open PHACTS Mission:
Integrate Multiple Research Biomedical Data Resources
Into A Single Open & FreeAccess Point
![Page 22: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/22.jpg)
Sustaining Impact“Software is free like puppies are free - they both need money for maintenance”
…and more resource for future development
![Page 23: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/23.jpg)
![Page 24: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/24.jpg)
![Page 25: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/25.jpg)
[email protected] @Open_PHACTS
Open PHACTS Practical Semantics
AcknowledgementsPfizer Limited – Coordinator
Universität Wien – Managing entity
Technical University of Denmark
University of Hamburg, Center for Bioinformatics
BioSolveIT GmBH
Consorci Mar Parc de Salut de Barcelona
Leiden University Medical Centre
Royal Society of Chemistry
Vrije Universiteit Amsterdam
Novartis
Merck Serono
H. Lundbeck A/S
Eli LillyNetherlands Bioinformatics CentreSwiss Institute of BioinformaticsConnectedDiscoveryEMBL-European Bioinformatics Institute
Janssen Esteve Almirall
OpenLink Scibite
The Open PHACTS Foundation
Spanish National Cancer Research Centre
University of Manchester
Maastricht University
Aqnowledge
University of Santiago de Compostela
Rheinische Friedrich-Wilhelms-Universität Bonn
AstraZeneca
GlaxoSmithKline
![Page 26: The Open PHACTS Discovery Platform Open PHACTS for Academia](https://reader035.vdocuments.us/reader035/viewer/2022062801/56649e185503460f94b0411e/html5/thumbnails/26.jpg)