the myelodysplastic syndromes: what they are, what they mean and what are we doing about it anthony...
TRANSCRIPT
![Page 1: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/1.jpg)
the Myelodysplastic Syndromes:
what they are, what they mean and what are we doing about it
Anthony Woods, MDSeptember 30, 2006
![Page 2: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/2.jpg)
outline
• what is myelodysplasia?• diagnosis & classification• treatment strategies• specialty clinics
![Page 3: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/3.jpg)
What is…?
“clonal disorder affecting hematopoietic maturation, characterized by ineffective hematopoiesis and bone marrow failure
with resultant cytopenias, often culminating in florid acute leukemia”
huh?
![Page 4: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/4.jpg)
historically
• reports of cytopenic disorders began appearing in the early 20th century
1942: “odo-leukemia” • odo = threshold (Chevalier et al)
1949: “preleukemic anemia” (Hamilton-Paterson)
1953: expanded definition to include all blood lines “clonal myeloid hemopathy”
(Block et al)
![Page 5: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/5.jpg)
historically
• other terms used over the last 50 years:– herald state of leukemia– refractory anemia– sideroachrestic anemia– idiopathic refractory sideroblastic anemia– pancytopenia with hyperplastic marrow– oligoblastic leukemia
![Page 6: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/6.jpg)
soapbox
no surprise that there is confusion and ignorance about this disorder:
historical coupling of MDS to acute myeloid leukemia
• there is a relationship• has hindered consideration of MDS as
a distinct entity– biased investigational and therapeutic
efforts towards the leukemia
![Page 7: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/7.jpg)
historically
• Paris, 1975: hemopoietic dysplasia– subsequently shortened to
myelodysplasia
• 1982: French-American-British classification scheme (FAB)
• 1999-2002: World Health Organization classification scheme
![Page 8: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/8.jpg)
What is myelodysplasia?
• disordered production of one or more cell lines
“dysplasia”
abnormal growth and differentiation of hematopoietic precursors
• abnormal appearance under the microscope
![Page 9: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/9.jpg)
normal blood
![Page 10: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/10.jpg)
dysplastic features - blood
![Page 11: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/11.jpg)
dysplastic features - blood
normal
![Page 12: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/12.jpg)
dysplastic features - blood
![Page 13: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/13.jpg)
normal bone marrow
![Page 14: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/14.jpg)
normal bone marrow
![Page 15: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/15.jpg)
dysplasia – bone marrow
![Page 16: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/16.jpg)
dysplasia – bone marrow
![Page 17: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/17.jpg)
dysplasia – bone marrow
![Page 18: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/18.jpg)
dysplasia – bone marrow
![Page 19: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/19.jpg)
what goes wrong with marrow cells?
• multistep process• sequence of successive DNA
mutations in an early blood cell precursor cell
• evolution of this cell into a “clone”– self-reproducing abnormal cell– growth advantage over normal marrow
cells
![Page 20: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/20.jpg)
what goes wrong with marrow cells?
complex multistep process:• DNA mutations in an early blood cell
precursor cell• emergence as an abnormal clone
– self-reproducing, abnormal cell– growth advantage over normal marrow
cells BUT at the same time incapable of producing normal blood cells
![Page 21: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/21.jpg)
what goes wrong with marrow cells?
expansion of the abnormal clone results in ineffective hematopoiesis– marrow looks full– no useful blood cell production actually
occurring– suppression and inhibition of normal
marrow growth
“weeds growing in the garden”Dr. R. Wells
![Page 22: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/22.jpg)
what goes wrong with marrow cells?
• worse, over time the clone becomes more and more unstable
• ~ 25% of persons with MDS develop acute myeloid leukemia
![Page 23: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/23.jpg)
what goes wrong with marrow cells?
C. Willman, ASH Education Program, 2000
MDS AML
![Page 24: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/24.jpg)
causes
• may follow exposures to bone marrow toxins– chemotherapy– radiation– organic compounds
• some follow inherited tendencies• Fanconi anemia, disorders of DNA repair
• > 80% have no identifiable exposure or cause
![Page 25: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/25.jpg)
in whom and how often
• can affect people of any age– including children
• more common in advancing age– North America: mid-late 60’s– China: 50
• 10000-15000 new diagnoses per year in USA– Canada 10% ?
![Page 26: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/26.jpg)
in whom and how often
MDS Foundation estimates that in people older than 70 there are
15 - 50 new diagnoses / 100,000 persons per year
extrapolating USA estimates, perhaps 3000 - 6000 Canadians have an MDS
diagnosis at any given time
![Page 27: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/27.jpg)
diagnosis
• requires suspicion• typically 2 settings where MDS
should be suspected:
1. signs or symptoms of a blood disorder
– fatigue, exercise intolerance, pale– serious or recurrent infections– inappropriate bleeding and bruising
![Page 28: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/28.jpg)
diagnosis
2. unexpected finding in blood suggesting MDS:
– low blood count of any kind• > 80% have anemia ± others• 30 – 45% have low platelets
– macrocytosis (large red cells)– high monocyte count– abnormal appearing blood cells
![Page 29: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/29.jpg)
diagnosis
required evaluation:• complete history and examination• complete blood counts and diff• iron, B12 and folate levels• bone marrow aspirate & biopsy
– chromosome analysis: “cytogenetics”
• serum erythropoietin levels– prior to transfusions
![Page 30: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/30.jpg)
diagnosis
• tests that are useful in some clinical circumstances
– HLA tissue typing (if BMT a consideration)
– HIV testing– other specific tests
• PNH• other HLA determinations
![Page 31: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/31.jpg)
diagnosis
• no perfect diagnostic test• no absolute diagnostic criteria
• combination of findings:– appearance of dysplasia in blood and
marrow– abnormal cytogenetic testing
![Page 32: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/32.jpg)
complications
related to low blood counts• fatigue, decreased exercise tolerance• serious, recurrent infection• bleeding
• the latter two are responsible for the majority of severe and life-threatening complications of MDS
![Page 33: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/33.jpg)
complications
• approximately 25% of patients undergo a transformation to acute myeloid leukemia
• arbitrary distinction of having 20% blast cells in bone marrow
• represents an increase in the aggressiveness of their MDS
• associated with a worse prognosis
![Page 34: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/34.jpg)
complications
suspected if:
• drop in baseline blood counts• higher blast cell numbers showing up
in blood• higher transfusion requirements• non-specific symptoms
– weight loss
![Page 35: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/35.jpg)
classification
2 classification systems still in use
• FAB System
• newer WHO classification
![Page 36: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/36.jpg)
FAB classification
• many clinicians still primarily use this system
• framework upon which newer classifications are built
• FAB grouping gives prognostic information: all tables from Steensma et al, May Clin Proc, 2006
![Page 37: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/37.jpg)
FAB classification
FAB median survival % progressing to class (months) acute leukemia
RA 37 11RARS 49 5RAEB 9 23
RAEB-t 6 48CMML 22 20
![Page 38: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/38.jpg)
WHO Classification
meant to refine the FAB system:• incorporated new information
– cytogenetics
• added subcategories for recognized specific sub-entities– 5q- syndrome
• also takes into account changes in AML diagnostic criteria– 20% vs 30%
![Page 39: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/39.jpg)
WHO Classification
![Page 40: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/40.jpg)
International Prognostic Scoring System
• need for a better system to predict prognosis in certain patient groups
• IPSS: a tool specifically designed for prognostic purposes
• arose out of a 1997 international workshop on MDS Risk Analysis
• analyzed factors in 816 patients
![Page 41: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/41.jpg)
IPSS calculation
![Page 42: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/42.jpg)
therapy
• many potential therapies available to & tried in MDS patients
• most show some benefit
• most benefits are– small– only in a minority subset of patients
• hard to know who should receive them and what to expect
![Page 43: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/43.jpg)
transfusion and general supportive measures
• most persons with MDS require transfusion support at some time during their course
• most people do not tolerate hemoglobin < 80 g/L– at least 80 or for comfort/symptoms– CMV negative products in potential BMT
recipients
![Page 44: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/44.jpg)
therapy
• platelet transfusion is individualized based on baseline counts and bleeding symptoms– alloimmunization to platelets– local blood bank guidelines
• adjunctive agents can be used– tranexamic acid
![Page 45: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/45.jpg)
therapy
• management of iron overload– Dr. Wells
![Page 46: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/46.jpg)
therapy
• prompt attention given to infectious symptoms
• primary care physicians should be aware of increased importance of infections in persons with MDS
• trials of growth factors with infections– inpatient setting– selected outpatients
![Page 47: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/47.jpg)
therapy
growth factors: erythropoietin and G-CSF
• rationale is to encourage hematopoiesis
• responses are variable
• expensive, not readily obtainable to everyone– 3rd party insurance– “sneak” past renal guidelines
![Page 48: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/48.jpg)
therapy• EPO compounds (Eprex) have
generally shown response rates of 15-20%
• better responses seen in:– RCMD-RS– low EPO levels– lighter transfusion needs
• responses generally last 1-2 years• doses: 40-60,000 units SC weekly• newer compounds appear equally
effective– darbepoietin (Aranesp)
![Page 49: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/49.jpg)
therapy
• response rates may increase up to twofold if recombinant granulocyte colony stimulating factor (G-CSF) is added
• generally done in a stepwise fashion• doses of 1 µcg/kg day typical starting
point
• similar difficulties in obtaining drug
![Page 50: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/50.jpg)
therapy
chemotherapy
• high-risk MDS patients with high blast counts or those who have transformed are candidates for treatment with traditional chemotherapy regimens
• similar to AML therapy
![Page 51: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/51.jpg)
therapy
epigenetic therapy
• DNA transcription (and normal cell growth and development) in MDS can be altered by factors not directly related to DNA sequences– chemical alterations of DNA itself– chemical changes in support proteins
• histones
![Page 52: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/52.jpg)
therapy
• demethylation agents: allow transcription of key tumor suppressor genes
• histone deacetylation agents: alter binding of DNA to histones and increase “accessibility” of DNA to transcription factors
![Page 53: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/53.jpg)
therapy
5-azacytidine• methyltransferase inhibitor
• delays progression of MDS• improvements in blood counts in ~
20% patients• improvements in quality of life• neutropenia observed as side effect
(!)
![Page 54: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/54.jpg)
therapy
5-aza-2’-deoxycytabine (decitabine)• similar mechanism• less neutropenia & similar response
rates– perhaps substantially better in some
European studies
• availability and difficulties with awkward approved dosing schedules have been obstacles
![Page 55: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/55.jpg)
therapy
immune suppression• antithymocyte globulin, cyclosporine
– responses of 20-30% in trials– pts with relatively hypoplastic marrows
appear to be better candidates
immunomodulatory therapy• thalidomide and lenalidomide
![Page 56: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/56.jpg)
therapy
thalidomide has shown promise, but has an unfavorable toxicity profile in MDS
• have had > 33% drop-out rates in studies
![Page 57: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/57.jpg)
therapy
lenalidomide (Revlimid): exciting!• large improvements seen in
transfusion requirements– best in 5q- patients, but also in other
karyotypes– normalization of cytogenetics
• appears much less toxic– reversible neutropenia and
thrombocytopenia
• availability!
![Page 58: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/58.jpg)
therapy
• vitamins: high-dose B complex• danazol: thrombocytopenia• monoclonal antibodies• splenectomy
all may have roles in individual patients
![Page 59: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/59.jpg)
therapy
• stem cell transplantation– Dr. L. Savoie
• definite role in select patients– higher-risk disease– younger patients
![Page 60: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/60.jpg)
therapy: general algorithm
BMT transplant candidate:
•young
•good performance status
•high risk MDS
•suitable donor
YES consider BMT
NO
Low risk MDS:•clinical trials•growth factors•biological agents•immune therapy
High risk MDS:•clinical trials•leukemia-styletherapy•biological agents
![Page 61: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/61.jpg)
The Role of the Specialty Clinic:
1. provide guidance for primary caregivers
2. maximize supportive care3. optimize individualized
management5. dissemination of current state of
knowledge
4. clinical trials &5. data collection:
![Page 62: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/62.jpg)
![Page 63: The Myelodysplastic Syndromes: what they are, what they mean and what are we doing about it Anthony Woods, MD September 30, 2006](https://reader036.vdocuments.us/reader036/viewer/2022062511/5517c3b655034616658b4885/html5/thumbnails/63.jpg)