Presents Theoretical, Regulatory, and Practical InformationThe Minipig in Biomedical Research is a comprehensive resource for research scientists on current and futureuse of the minipig in basic and applied biomedical research and the development of drugs and chemicals.Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experiencewith regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widelyover the biology and scientific and practical uses of the minipig in the laboratory. Its coverage extends fromthe minipig’s origins, anatomy, genetics, immunology and physiology to welfare, health, and husbandry;practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and theuses of the minipig as a disease model. Regulatory aspects of its use are considered.

Readers will find an extensive amount of theoretical and practical information in the pharmacology, ADMEand toxicology chapters which will help scientists and managers when deciding which species to use in basicresearch, drug discovery, and pharmacology and toxicology studies of chemicals, and biotechnology productsand devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary phar-maceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normallaboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in theirsupply, housing, and transport. The result is an all-inclusive and up to date manual about the experimentaluses of the minipig that describes ‘How to’ and ‘Why’ and ’What to expect in the normal’, combining enthu-siasm and experience with critical assessment of its values and potential problems.

ContentsOrigin and Management of the MinipigHistory and Development of Miniature, Micro- andMinipigsHusbandry and ManagementDiseases of MinipigsInternational Transportation of MinipigsWelfare and Experimental Usage of the MinipigEthical Issues in the Use of Minipigs in Animal ResearchAnimal Welfare IssuesStress in ExperimentsDosing MethodsIn-life Clinical ObservationsPharmacology and ADME Studies in the MinipigMinipigs in Absorption, Distribution, Metabolismand Excretion (ADME) StudiesSafety PharmacologySafety Assessment in the Minipig – PrincipalBody SystemsDermal Toxicity Studies: Skin Architecture, Metabolism, Penetration and Toxicological andPharmacological MethodsGastrointestinal TractHeart and CardiotoxicityCentral and Peripheral Nervous SystemsThe KidneyReproductive System including Studies in JuvenileMinipigsThe Endocrine SystemSkeletal SystemOcular Examination and Background ObservationsSpontaneous/Background Pathology of the Göttin-gen MinipigGenetics and ImmunologyA Comparative Assessment of the Pig, Mouse, and Human Genomes: Structural and FunctionalAnalysis of Genes Involved in Immunity and Inflammation

The Immune System of Pigs: Structure and FunctionAllotransplantation in Miniature SwineXenotransplantationPorcine endogenous retroviruses (PERVs) in xenotransplantation - A review of the importance ofPERVs in porcine studies, with particular emphasison the minipigImmunotoxicity Studies in MinipigsDisease ModelsCreation and conservation of genetically modifiedpigs: applications to genetic disease model andxenotransplantationStem Cell Research and MinipigsMinipig Models of Diabetes MellitusDiet-induced AtherosclerosisHaemorrhage and Resuscitation Models UsingMiniature SwineOral Biology and Dental ModelsOsteoporosis Model in MinipigsWound Healing ModelsThe Minipig in Chemical, Biological and Radiological Warfare ResearchThe Minipig and Pig in Medical Device ResearchRegulatory Perspective and Use of the Minipig inDeveloping Marketed ProductsRegulatory Aspects – Pharmaceuticals, Medical Devices and Food AdditivesAdverse Responses to Drugs in Man: a critical comparison of reported toxicological findings inminipigs and humansUse of Minipigs in Testing Agrochemicals, Food Additives, and Industrial Chemicals,New Horizons and PerspectivesFuture Prospects: Possibilities and Perspectives

Peter A. McAnulty, Anthony D. Dayan,

Niels-Christian Ganderup, and Kenneth L. Hastings

Catalog no. K10559December 2011, c. 600 pp.ISBN: 978-1-4398-1118-4

$189.95 / £121.00

Features

• Describes best practices in husbandry, transport, and experimentation

• Explains and illustrates clinical, practical,and experimental techniques and procedures

• Provides many examples of successful useof the minipig in basic and regulatorytoxicity studies of drugs and devices

• Discusses clinical and physiological find-ings and laboratory values in health anddisease

THE MINIPIG IN BIOMEDICAL RESEARCH CRC PressTaylor & Francis Group

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The Definitive Source for Using Swine in Research

To diminish the learning curve associated with using swine as models, Swine in the Laboratory: Surgery,Anesthesia, Imaging, and Experimental Techniques, Second Edition provides practical technical informa-tion for the use of swine in biomedical research. The book focuses on models produced by surgical and otherinvasive procedures, supplying the basic principles for performing experiments with an organ or system of in-terest.

New to the Second Edition

• Updated sections on anesthesia and perioperative care, including practical information for more complex models

• Expansion of anatomic and physiologic details

• Additional detail in the endoscopy section

• Chapters on toxicology and radiobiology

• Chapters that include angiographic, echocardiographic, CT, MRI, and PET imaging techniques with a corresponding DVD of the images

• More tables of normal values on the most commonly used minipigs and domestic breeds

Beneficial for investigators, veterinarians, and technicians using swine for experimental and agricultural procedures, Swine in the Laboratory is certain to foster the appropriate, humane use of swine in biomedicalresearch.

Contents

Biology, Handling, Husbandry, and Anatomy

Anesthesia, Analgesia, and Perioperative Care

Wound Closure and Integument

Gastrointestinal Procedures

Liver and Biliary System

Pancreas and Spleen

Urinary System and Adrenal Glands

The Reproductive System

Cardiothoracic and Vascular Surgery/Chronic Intravascular Catheterization

Head and Neck Surgery/Central Nervous System

Musculoskeletal System and Orthopedic Procedures

Cardiovascular Catheterization, Electrophysiology, and Imaging Laboratory Procedures

Endoscopic, Laparoscopic, and Minimally Invasive Surgery

Xenotransplantation and Transgenic Technologies

Toxicology

Radiobiology

Imaging Techniques: Ct, Mri, and Pet Scanning

Ossabaw Island Miniature Swine: Cardiometabolic Syndrome Assessment

Appendix

Index

M. Michael SwindleMedical University of South Carolina,

Charleston, USA

SWINE IN THE LABORATORY CRC PressTaylor & Francis Group

Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition

Catalog no. 92782007, 496 pp.

ISBN: 978-0-8493-9278-8$149.95 / £82.00

Features

• Continues to be a comprehensive source ofinformation on using swine in biomedicalresearch, especially in the area of experi-mental surgery

• Lists generic drug names with dosages foranesthetic agents, cardiovascular drugs,and analgesics

• Includes never-before-published images aswell as data on normative anatomy, savingthe need for extra research

• Provides extended reference lists at the endof each chapter

• Contains a DVD with three-dimensional,full-color images

SAVE 20% Order online at www.crcpress.com and enter PROMO CODE XBL11. Expires 3/16/12