the mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · donor selection...

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Page 1: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international
Page 2: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Donor selection

Haplo versus cord

Resource limited environment

Donor registries

Domestic versus international

donor registries

Page 3: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Haplo versus cord

Page 4: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international
Page 5: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international
Page 6: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Placental blood

Four domestic public banks

Several private banks

Expensive cords from abroad (NMDP)

Poor quality of the domestic cords

Page 7: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Placental blood

Domestic cord: 3 000 USD

Imported cord: 30 000 USD

Restrictive

Page 8: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

2006

Page 9: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

68 placental blood allografts

Page 10: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Haploidentical allografts

Page 11: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

vs

Page 12: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Hematology 2013, in the press

Page 13: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

18 haploidentical allografts

Page 14: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

cords

haplos

Page 15: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Haplos versus cords

Similar long term results

Haplos are cheaper (Cy)

No cord blood banks

More realistic in

underprivileged circumstances

Page 16: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Resource limited

environment

Page 17: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Centers participating in the CIBMTR 2011

SUM-WW11_2.ppt

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Page 18: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international
Page 19: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

BBMT 2009; 15:1628

Page 20: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Traditional Mexican approach

Impossible

Impossible

++

++

Possible

Possible

+ / -

+

30 – 50%

300 000 USD

Difficult

17 %

20 000 USD

Possible

Self-recovery

Outpatient

Transfusions

GVHD

100-day mortality

Cost

Developing countries

Allografts

Page 21: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Donor registries

Page 22: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

Donor registries

Domestic: DONORMO

• Less than efficient

• Transplant center restricted

• Expensive

International

• CRIR

• NMDP

Page 23: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international
Page 24: The Mexican approach to conduct non-myeloablative stem cell … · 2020-05-01 · Donor selection Haplo versus cord Resource limited environment Donor registries Domestic versus international

….. this is the end-result of

sodality and friendship, two

uncommon values in a culture

driven by rivalry, jealousy,

disqualification, economic interest

and the zeal to reach that vacuum

known as success……

Julio Glockner