CoQ10The Metabolic Antioxidant

TO ORDER CALL 800-753-2277 Secure online ordering and information at www.PureEncapsulations.com2

Committed to CoQ10 Excellence • Japanese-sourced CoQ10 only • Natural, fermented CoQ10 • Trans-isomer only; No cis-isomer impurities

Committed to CoQ10 Science • Q-Gel, Ubiquinol and Sustained Release forms of CoQ10 • Product Sponsor: “A Randomized, Controlled Trial of Two Dosage Forms of CoQ10 for the Improvement of Statin-Related Myalgia and Muscle Pain.”

“The many facets of coenzyme Q10 as a metabolic cofactor, antioxidant and membrane stabilizer render it one of the most versatile, evidence-based tools in the holistic, integrative and allopathic repertoire of nutritional supplements. As an isoprenoid quinone redox cofactor, its rare physiochemical properties lend a functional profile that no vitamin or essential nutrient can recapitulate. The functional spectrum of CoQ10 traverses the most salient determinants of good health, including metabolism, neuroprotection and cardiovascular homeostasis. Over 50 years since its initial discovery, cross-disciplinary research in molecular medicine continues to unveil important roles that stem from multifocal bioenergetic and genomic targets.” — Kelly C. Heim, Ph.D.

TO ORDER CALL 800-753-2277 Secure online ordering and information at www.PureEncapsulations.com2

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 3

CoQ10

CoQ10 500 mg each vegetable capsule contains v 00

coenzyme Q10 ...................................................................................................................... 500 mg(hypo-allergenic plant fiber may be added to complete capsule volume requirement)

1–2 capsules per day, in divided doses, with meals. quantity order code

CoQ10 500 mg 60 CQ56

CoQ10 250 mg each vegetable capsule contains v 0

coenzyme Q10 ...................................................................................................................... 250 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)

1–2 capsules per day, in divided doses, with meals. quantity order code

CoQ10 250 mg 60 CQ26

CoQ10 120 mg each vegetable capsule contains v 0

coenzyme Q10 ...................................................................................................................... 120 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)

1–2 capsules per day, in divided doses, with meals. quantity order code

CoQ10 120 mg 120 CQ11 60 CQ16 30 CQ13

CoQ10 60 mg each vegetable capsule contains v 3

coenzyme Q10 ........................................................................................................................ 60 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)

1–2 capsules per day, in divided doses, with meals. quantity order code

CoQ10 60 mg 250 CQ62 120 CQ61 60 CQ66

CoQ10 30 mg each vegetable capsule contains v 3

coenzyme Q10 ........................................................................................................................ 30 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)

2–4 capsules per day, in divided doses, with meals. quantity order code

CoQ10 30 mg 120 CQ31

See our multivitamins with CoQ10 UltraNutrient® Athletic Nutrients PureOne Nutrients UltraPure Pack Men’s Pure Pack Women’s Pure Pack Athletic Pure Pack

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 3

Independent Third Party Testing

TO ORDER CALL 800-753-2277 Secure online ordering and information at www.PureEncapsulations.com4

Cardiokinase™ w/CoQ10

• Fibrinolytic enzyme produced using new nattokinase fermentationprocess*

• May have over 10% greater lymphatic absorption and 20% greatereffectiveness than other nattokinases*

• Unique CoQ10 /ubiquinol complex for enhanced circulatory support*

Kaneka QH™ is a trademark of Kaneka Corporation.

two vegetable capsules contain 3Cardiokinase™ (nattokinase strain N) (25 i.u.) (from non-GMO soy) .............................100 mg coenzyme Q10 ............................................................................................................................60 mg ubiquinol (Kaneka QH™ active antioxidant form of coenzyme Q10) ................................40 mgascorbyl palmitate (fat-soluble vitamin C) ...........................................................................10 mgother ingredients: gelatin beadlet, cornstarch, mixed tocopherols

Take 1 capsule in the morning and 1 capsule in the evening, 1/2 hour before meals. quantity order code

Cardiokinase™ w/CoQ10 60 CKQ6

CoQ10 l-Carnitine fumarate

• Dual support for heart muscle function and oxygenation* • Supports skeletal muscle energy and moderates lactate levels*

DuraCarn™ is a registered trademark of Sigma-Tau HealthScience, Inc. U.S. Patent pending.

The combination of l-Carnitine and CoQ10 is produced under a non-exclusive license from SIGMA-TAU/BIOSINT, U.S. patent number 4,599,232.

each vegetable capsule contains v 00

l-carnitine (free-form) ......................................................................................................... 340 mg (from 586 mg l-carnitine fumarate)

coenzyme Q10 ......................................................................................................................... 60 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)

2–4 capsules per day, in divided doses, with meals. quantity order code CoQ10

l-Carnitine fumarate 120 CQF1

RiboCarnitine-Q10

• Patented, synergistic carnitine combination • Supports strenuous exercise via muscle adaptation; helps lessen

fatigue*• Enhances cardiac function with CoQ10 for added vascular and lipid

support*• Features ribose for both energy and cardiac support properties*GlycoCarn® is a registered trademark of Sigma-Tau HealthScience and is manufactured under U.S. Patent 6,703,042 and European Patent 1,202,956. The combination of GlycoCarn® GPLC and CoQ10 is patented by Sigma-Tau Industries under U.S. Patent 6,814,972. The combination of GlycoCarn® GPLC, l-carnitine and acetyl-l-carnitine is patented under U.S. Patent 6,245, 378.

Use of d-ribose by Pure Encapsulations is authorized by Bioenergy, Inc. under U.S. Patents 4,605,644; 4,719, 201.

three vegetable capsules contain v 00

d-ribose .................................................................................................................................1,000 mg l-carnitine (free-form) (from l-carnitine fumarate) ...........................................................250 mg GlycoCarn® GPLC (glycine propionyl-l-carnitine HCl) .....................................................150 mgacetyl-l-carnitine (from acetyl-l-carnitine HCl) ................................................................125 mg coenzyme Q10 ............................................................................................................................50 mg ascorbyl palmitate (fat-soluble vitamin C) ....................................................................60 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)other ingredients: silica

3–6 capsules per day, in divided doses, with meals. quantity order code

RiboCarnitine-Q10 180 RCQ1

TO ORDER CALL 800-753-2277 Secure online ordering and information at www.PureEncapsulations.com4

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 5

Q-Gel® (Hydrosoluble™ CoQ10)

• Water and oil soluble CoQ10 • Provides enhanced bioavailability in more body tissues* • Manufactured via the patented Bio Solv® processQ-Gel® and Bio Solv® are registered trademarks of Tishcon Corp. Hydrosoluble™ is a trademark of Tishcon Corp. Manufactured under one or more of the following

U.S.Patents: 6,056,971; 6,300,377; and 6,740,338.

Q-Gel® 100 (Hydrosoluble™ CoQ10) each softgel capsule contains 22 sg

vitamin E (d-alpha tocopheryl acetate) .....................................................................150 i.u.coenzyme Q10 .............................................................................................................. 100 mgContains soyother ingredients: gelatin, sorbitol, glycerin, purified water, annatto seed extract (natural color) in a patented Bio Solv® base (polysorbate 80, hydroxylated soy lecithin, medium chain triglycerides).

1–2 capsules per day, in divided doses, with meals. quantity order code Q-Gel® 100(Hydrosoluble™ CoQ10) 60 QG16

Q-Gel® 60 (Hydrosoluble™ CoQ10) each softgel capsule contains 16 sg

vitamin E (d-alpha tocopheryl acetate) .....................................................................150 i.u.coenzyme Q10 ................................................................................................................ 60 mgContains soyother ingredients: gelatin, glycerin, sorbitol, purified water, titanium dioxide, annatto seed extract (natural color) in a patented Bio Solv® base (polysorbate 80, soy lecithin, triacetin, medium chain triglycerides).

1–2 capsules per day, in divided doses, with meals. quantity order code Q-Gel® 60(Hydrosoluble™ CoQ10) 60 QG66

4-Week Q-Gel vs. Reference Study

ME

AN

PLA

SM

A C

oQ

10 V

ALU

ES

(µ

g/m

L)

DAYS OF SUPPLEMENTATION

3.50

3.00

2.50

2.00

1.50

1.00

0.50

0.000 7 14 21 28

ReferenceQ-Gel

Mean plasma CoQ10 values during four weeks of supplementation with CoQ10 suspension in oil (softgel capsules) as the reference and Q-Gel (softgel capsules). Q-Gel significantly differs from CoQ10 suspension in oil at 28 days. p=0.0000

5*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

TO ORDER CALL 800-753-2277 Secure online ordering and information at www.PureEncapsulations.com6 TO ORDER CALL 800-753-2277 Secure online ordering and information at www.PureEncapsulations.com6

Ubiquinol

• Developed after 10 years of research by leading manufacturerKaneka Corporation

• Active antioxidant form of CoQ10

• “Activated” by presence of two hydrogen atoms• Enhanced potential to increase serum levels*

• Preferred form for individuals over 40 or individuals experiencingincreased oxidative stress*

Kaneka QH™ is a trademark of Kaneka Corporation.

The use of ascorbyl palmitate in the formulation is covered by U.S. Patent 6,740,338.

Ubiquinol-QH 200 mg each softgel capsule contains 16 sg

ubiquinol (Kaneka QH™ active antioxidant form of coenzyme Q10) ...............................200 mgContains soyother ingredients: medium chain triglycerides, gelatin, glycerin, ascorbyl palmitate, purified water, beeswax, soy lecithin, annatto extract.

Take 1 softgel per day with a meal, or as directed by a health professional. quantity order code

Ubiquinol-QH 200 mg 60 UQ26

Ubiquinol-QH 100 mg each softgel capsule contains 14 sg

ubiquinol (Kaneka QH™ active antioxidant form of coenzyme Q10) ...............................100 mgContains soyother ingredients: medium chain triglycerides, gelatin, glycerin, ascorbyl palmitate, purified water, beeswax, soy lecithin, annatto extract.

Take 1–2 softgels per day with meals. quantity order code

Ubiquinol-QH 100 mg 60 UQ16

Ubiquinol-QH 50 mg each softgel capsule contains 10 sg

ubiquinol (Kaneka QH™ active antioxidant form of coenzyme Q10) .................................50 mgContains soyother ingredients: medium chain triglycerides, gelatin, glycerin, ascorbyl palmitate, purified water, beeswax, soy lecithin, annatto extract.

Take 1–2 softgels per day with meals. quantity order code

Ubiquinol-QH 50 mg 60 UQ56

4-Week Multiple Dose Kaneka QHTM Study

Pla

sma

ub

iqu

ino

l co

nc.

(µ

g/m

L)

Time after first dose (days)

10

8

6

4

2

00 7 14 21 28 35 42 49

Treatment

300 mg150 mg90 mg

Morning trough concentrations of ubiquinol in plasma during 4-week multiple oral administration of ubiquinol and 2 weeks after completion of the treatment in healthy volunteers. Each point represents the mean +/-SEM of 20 subjects (90 mg and 150 mg) or 19 subjects (300 mg).

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 7

SR-CoQ10 with PQQ

• 24-hour sustained release MicroActive® CoQ10 • Combined with BioPQQ™, a B vitamin-like cofactor* • For enhanced cardiac, neural and cognitive health* • Convenient, once-daily dosing

two vegetable capsules contain v 0

coenzyme Q10 (from MicroActive® Q10-cyclodextrin complex).......................................100 mg BioPQQ™ pyrroloquinoline quinone disodium salt ..............................................................20 mg(hypo-allergenic plant fiber added to complete capsule volume requirement)other ingredients: potato starch, vegetable capsule

2 capsules per day, in the morning, with a meal. quantity order code

SR-CoQ10 with PQQ 60 CQP6

SR-CoQ10 Absorption in Human Volunteers

Figure 1. Comparison of the mean plasma CoQ10 concentrations after a single oral dose of either SR-CoQ10 or solubilized softgel CoQ10.

Mitochondrial, Cognitive and Cardiovascular Mechanisms of CoQ10 and PQQ

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. 7

Pure Encapsulations, Inc., 490 Boston Post Road, Sudbury, Massachusetts 01776 USAinfo@pureencapsulations.com www.PureEncapsulations.com T: 800-753-2277 F: 888-783-2277

EPA/DHA-CoQ10

• Features ultra-pure, molecularly distilled fish oil • Provides omega-3/CoQ10 combination for enhanced heart health*

each softgel capsule contains 20 sg

calories ............................................................................................................................................ 10 calories from fat .......................................................................................................................... 10total fat ............................................................................................................................................1 g fish oil concentrate (anchovies, sardines) .........................................................................900 mg

providing:EPA (eicosapentaenoic acid) ...................................................................... 270 mg DHA (docosahexaenoic acid) ...................................................................... 180 mg

coenzyme Q10 ............................................................................................................................50 mgvitamin E (d-alpha-tocopherol) ............................................................................................. 10 i.u.other ingredients: annatto extract, beeswax, gelatin capsule

1 or more capsules per day, with meals. quantity order code

EPA/DHA-CoQ10 120 EDQ1

EPA/DHA-CoQ10 liquid

• Convenient, natural orange flavored liquid

each teaspoon (5 ml / 0.18 fl oz) provides

calories ............................................................................................................................................ 40 calories from fat .......................................................................................................................... 40total fat .........................................................................................................................................4.5 g saturated fat ...............................................................................................................................1 gcholesterol ................................................................................................................................25 mgfish oil concentrate (anchovies, sardines) .....................................................................4,295 mg

providing (typical):EPA (eicosapentaenoic acid) ............................................................. 687–859 mg DHA (docosahexaenoic acid) ............................................................. 429–644 mg

coenzyme Q10 ........................................................................................................................ 100 mgother ingredients: natural orange and citrus flavors, proprietary antioxidant blend (natural vitamin E, rosemary extract and ascorbyl palmitate)This formula requires refrigeration after opening. Best when consumed within 90 days after opening. Contents may appear cloudy when refrigerated. Contents may precipitate; shake well.1–3 teaspoons per day, with meals.

quantity order code EPA/DHA-CoQ10 liquid(orange flavor) 200 ml (7 fl oz) EDO2