the material balance for chemical reactors - rawlings group
TRANSCRIPT
The Material Balance for Chemical ReactorsCopyright c© 2018 by Nob Hill Publishing, LLC
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General Mole Balance
Rj
V
Q1
cj1
Q0
cj0
Conservation of mass
rate of
accumulationof component j
={
rate of inflowof component j
}−{
rate of outflowof component j
}
+
rate of generationof component j bychemical reactions
(4.1)
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General Mole Balance
Rj
V
Q1
cj1
Q0
cj0
Conservation of mass
ddt
∫V
cjdV = Q0cj0 −Q1cj1 +∫
VRjdV (4.2)
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General Mole Balance
ddt
∫V
cjdV = Q0cj0 −Q1cj1 +∫
VRjdV
Equation 4.2 applies to every chemical component in the system,j = 1,2, . . . ,ns, including inerts, which do not take place in any reactions.
Assuming component j enters and leaves the volume element only byconvection with the inflow and outflow streams, i.e. neglecting diffusional fluxthrough the boundary of the volume element due to a concentration gradient.
The diffusional flux will be considered during the development of the materialbalance for the packed-bed reactor.
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Rate expressions
To solve the reactor material balance, we require an expression for theproduction rates, Rj
Rj =∑
i
νijri
Therefore we require ri as a function of cj
This is the subject of chemical kinetics, Chapter 5
Here we use common reaction-rate expressions without derivation
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The Batch Reactor
Rj
The batch reactor is assumed well stirred
Let the entire reactor contents be the reactor volume element
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Batch Reactor
ddt
∫V
cjdV = Q0cj0 −Q1cj1 +∫
VRjdV
Because the reactor is well stirred, the integrals in Equation 4.2 are simple toevaluate, ∫
VR
cjdV = cjVR
∫VR
RjdV = RjVR
The inflow and outflow stream flowrates are zero, Q0 = Q1 = 0.
d(cjVR
)dt
= RjVR (4.5)
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Reactor Volume
Equation 4.5 applies whether the reactor volume is constant or changesduring the reaction.
If the reactor volume is constant (liquid-phase reactions)
dcj
dt= Rj (4.6)
Use Equation 4.5 rather than Equation 4.6 if the reactor volume changessignificantly during the course of the reaction.
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Analytical Solutions for Simple Rate Laws
In general the material balance must be solved numerically.
If the reactor is isothermal, we have few components, the rate expressions aresimple, then analytical solutions of the material balance are possible.
We next examine derive analytical solutions for some classic cases.
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First-order, irreversible
Consider the first-order, irreversible reaction
Ak-→ B, r = kcA
The material balance for a constant-volume reactor gives
dcA
dt= −kcA (4.8)
Watch the sign!
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First-order, irreversible
We denote the initial concentration of A as cA0,
cA(t) = cA0, t = 0
The solution to the differential equation with this boundary condition is
cA = cA0e−kt (4.9)
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First-order, irreversible
0
0.2
0.4
0.6
0.8
1
0 1 2 3 4 5
k = 0.5
k = 1
k = 2
k = 5
cA
cA0
t
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First-order, irreversible
The A concentration decreases exponentially from its initial value to zero withincreasing time.
The rate constant determines the shape of this exponential decrease.Rearranging Equation 4.9 gives
ln(cA/cA0) = −kt
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First-order, irreversible
0.001
0.01
0.1
1
0 1 2 3 4 5
k = 0.5
k = 1
k = 2
k = 5
cAcA0
t
One can get an approximate value of the rate constant from the slope of thestraight line.
This procedure is a poor way to determine a rate constant and should beviewed only as a rough approximation (Chapter 9).
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First-order, irreversible
The B concentration is determined from the A concentration.
1 Solve the material balance for component B,
dcB
dt= RB = kcA (4.10)
with the initial condition for B, cB(0) = cB0
2 Note that the sum of cA and cB is constant.
d(cA + cB)dt
= RA + RB = 0
Therefore, cA + cB is a constant.
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First-order, reversible
The value is known at t = 0,
cA + cB = cA0 + cB0
So we have an expression for cB
cB = cA0 + cB0 − cA
cB = cB0 + cA0(1− e−kt) (4.11)
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First-order, reversible
Consider now the same first-order reaction, but assume it is reversible
Ak1-⇀↽-
k−1B
The reaction rate is r = k1cA − k−1cB .
The material balances for A and B are now
dcA
dt= −r = −k1cA + k−1cB cA(0) = cA0
dcB
dt= r = k1cA − k−1cB cB(0) = cB0
Notice that cA + cB = cA0 + cB0 remains constante
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First-order, reversible
Eliminate cB in the material balance for A gives
dcA
dt= −k1cA + k−1(cA0 + cB0 − cA) (4.13)
How do we want to solve this one?
Particular solution and homogeneous solution (see text)
Laplace transforms (control course)
Separation!
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First-order, reversible
dcA
dt= acA + b∫ cA
cA0
dcA
acA + b=∫ t
0dt
1aln(acA + b)
∣∣∣∣cA
cA0
= t
cA = cA0eat − ba(1− eat)
Substitute a = −(k1 + k−1), b = k−1(cA0 + cB0)
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First-order, reversible
cA = cA0e−(k1+k−1)t + k−1
k1 + k−1(cA0 + cB0)
[1− e−(k1+k−1)t
](4.15)
The B concentration can be determined by switching the roles of A and B andk1 and k−1 in Reaction 4.12, yielding
cB = cB0e−(k1+k−1)t + k1
k1 + k−1(cA0 + cB0)
[1− e−(k1+k−1)t
](4.16)
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First-order, reversible
0
0.2
0.4
0.6
0.8
1
0 1 2 3 4 5
cB(t)
cA(t)
cAs
cBs
c
t
Figure 4.5: First-order, reversible kinetics in a batch reactor, k1 = 1, k−1 = 0.5, cA0 = 1,cB0 = 0.
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Nonzero steady state
For the reversible reaction, the concentration of A does not go to zero.
Taking the limit t -→ ∞ in Equation 4.15 gives
cAs =k−1
k1 + k−1(cA0 + cB0)
in which cAs is the steady-state concentration of A.
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Nonzero steady state
Defining K1 = k1/k−1 allows us to rewrite this as
cAs =1
1+ K1(cA0 + cB0)
Performing the same calculation for cB gives
cBs =K1
1+ K1(cA0 + cB0)
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Second-order, irreversible
Consider the irreversible reaction
Ak-→ B
in which the rate expression is second order, r = kc2A.
The material balance and initial condition are
dcA
dt= −kc2
A , cA(0) = cA0 (4.18)
Our first nonlinear differential equation.
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Second-order, irreversible
Separation works heredcA
c2A= −kdt
∫ cA
cA0
dcA
c2A= −k
∫ t
0dt
1cA0− 1
cA= −kt
Solving for cA gives
cA =(
1cA0+ kt
)−1
(4.19)
Check that this solution satisfies the differential equation and initial condition
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Second-order, irreversible
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
0 1 2 3 4 5
first order
second order
cA
cA0
The second-order reaction decays more slowly to zero than the first-orderreaction.
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Another second-order, irreversible
A+ Bk-→ C r = kcAcB
The material balance for components A and B are
dcA
dt= −r = −kcAcB
dcB
dt= −r = −kcAcB
Subtract B’s material balance from A’s to obtain
d(cA − cB)dt
= 0
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Another second-order, irreversible
Therefore, cA − cB is constant, and
cB = cA − cA0 + cB0 (4.23)
Substituting this expression into the material balance for A yields
dcA
dt= −kcA(cA − cA0 + cB0)
This equation also is separable and can be integrated to give (you shouldwork through these steps),
cA = (cA0 − cB0)[
1− cB0
cA0e(cB0−cA0)kt
]−1
, cA0 ≠ cB0 (4.24)
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Another second-order, irreversible
Component B can be computed from Equation 4.23, or by switching the rolesof A and B in Reaction 4.20, giving
cB = (cB0 − cA0)[
1− cA0
cB0e(cA0−cB0)kt
]−1
What about component C? C’s material balance is
dcC
dt= kcAcB
and therefore, d(cA + cC )/dt = 0. The concentration of C is given by
cC = cA0 − cA + cC0
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Another second-order, irreversible
Notice that if cA0 > cB0 (Excess A), the steady state
cAs = cA0 − cB0
cBs = 0
cCs = cB0 + cC0
For cB0 > cA0 (Excess B), the steady state is
cAs = 0
cBs = cB0 − cA0
cCs = cA0 + cC0
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nth-order, irreversible
The nth-order rate expression r = kcnA
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
0 0.5 1 1.5 2 2.5 3
r
n = 3
2
1
1/2
0
cA
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nth-order, irreversible
Ak-→ B r = kcn
A
dcA
dt= −r = −kcn
A
This equation also is separable and can be rearranged to
dcA
cnA= −kdt
Performing the integration and solving for cA gives
cA =[c−n+1
A0 + (n − 1)kt] 1−n+1 , n ≠ 1
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nth-order, irreversible
We can divide both sides by cA0 to obtain
cA
cA0= [1+ (n − 1)k0t]
1−n+1 , n ≠ 1 (4.25)
in whichk0 = kcn−1
A0
has units of inverse time.
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nth-order, irreversible
0
0.2
0.4
0.6
0.8
1
0 1 2 3 4 5
1
2
3
4
n = 5cA
cA0
t
The larger the value of n, the more slowly the A concentration approacheszero at large time.
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nth-order, irreversible
Exercise care for n < 1, cA reaches zero in finite time.
0
0.2
0.4
0.6
0.8
1
0 0.5 1 1.5 2
cA
cA0 n = 2
1
1/20
−1/2−1−2
t
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Negative order, inhibition
For n < 0, the rate decreases with increasing reactant concentration; thereactant inhibits the reaction.
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
0 0.5 1 1.5 2 2.5 3
r
0
−1/2
−1
n=−2
cA
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Negative order, inhibition
Inhibition reactions are not uncommon, but watch out for smallconcentrations. Notice the rate becomes unbounded as cA approaches zero,which is not physically realistic.
When using an ODE solver we may modify the right-hand sides of the materialbalance
dcA
dt={−kcn
A , cA > 00, cA = 0
Examine the solution carefully if the concentration reaches zero.
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Two reactions in series
Consider the following two irreversible reactions,
Ak1-→ B
Bk2-→ C
Reactant A decomposes to form an intermediate B that can further react toform a final product C.
Let the reaction rates be given by simple first-order rate expressions in thecorresponding reactants,
r1 = k1cA
r2 = k2cB
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Two reactions in series
The material balances for the three components are
dcA
dt= RA = −r1 = −k1cA
dcB
dt= RB = r1 − r2 = k1cA − k2cB
dcC
dt= RC = r2 = k2cB
The material balance for component A can be solved immediately to givecA = cA0e−k1t as before.
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Two reactions in series – B
The material balance for B becomes
dcB
dt+ k2cB = k1cA0e−k1t
Oops, not separable, now what?
Either Laplace transform or particular solution, homogeneous equationapproach produces
cB = cB0e−k2t + cA0k1
k2 − k1
[e−k1t − e−k2t
], k1 ≠ k2 (4.30)
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Two reactions in series – C
To determine the C concentration, notice from the material balances thatd(cA + cB + cC )/dt = 0. Therefore, cC is
cC = cA0 + cB0 + cC0 − cA − cB
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Two reactions in series
0
0.2
0.4
0.6
0.8
1
0 1 2 3 4 5
cA(t)
cB(t)
cC (t)
c
t
Figure 4.11: Two first-order reactions in series in a batch reactor, cA0 = 1, cB0 = cC0 = 0,k1 = 2, k2 = 1.
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Two reactions in parallel
Consider next two parallel reactions of A to two different products, B and C,
Ak1-→ B
Ak2-→ C
Assume the rates of the two irreversible reactions are given by r1 = k1cA andr2 = k2cA.
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Two reactions in parallel
The material balances for the components are
dcA
dt= RA = −r1 − r2 = −k1cA − k2cA
dcB
dt= RB = r1 = k1cA
dcC
dt= RC = r2 = k2cA
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Two reactions in parallel
The material balance for A can be solved directly to give
cA = cA0e−(k1+k2)t (4.33)
Substituting cA(t) into B’s material balance gives
dcB
dt= k1cA0e−(k1+k2)t
This equation is now separable and can be integrated directly to give
cB = cB0 + cA0k1
k1 + k2
(1− e−(k1+k2)t
)(4.34)
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Two reactions in parallel
Finally, component C can be determined from the condition that cA + cB + cC isconstant or by switching the roles of B and C, and k1 and k2 in Equation 4.34,
cC = cC0 + cA0k2
k1 + k2
(1− e−(k1+k2)t
)(4.35)
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Two reactions in parallel
0
0.2
0.4
0.6
0.8
1
0 0.5 1 1.5 2 2.5 3
cA(t)
cB(t)
cC (t)
c
t
Figure 4.12: Two first-order reactions in parallel in a batch reactor, cA0 = 1, cB0 = cC0 = 0,k1 = 1, k2 = 2.
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Two reactions in parallel
Notice that the two parallel reactions compete for the same reactant, A
The rate constants determine which product is favored
Large values of k1/k2 favor the formation of component B compared to C andvice versa
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Conversion, Yield, Selectivity
There are several ways to define selectivity, yield and conversion, so be clearabout the definition you choose.
Point selectivity: The point (or instantaneous) selectivity is the ratio of the production rateof one component to the production rate of another component.
Overall selectivity: The overall selectivity is the ratio of the amount of one componentproduced to the amount of another component produced.
Yield: The yield of component j is the fraction of a reactant that is converted intocomponent j.
Conversion: Conversion is normally defined to be the fraction of a component that hasbeen converted to products by the reaction network. Conversion hasseveral definitions and conventions. It is best to state the definition in thecontext of the problem being solved.
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The Continuous-Stirred-Tank Reactor (CSTR)
Q
cj
Qf
cjf Rj
Writing the material balance for this reactor gives
d(cjVR
)dt
= Qf cjf −Qcj + RjVR, j = 1, . . . ,ns (4.36)
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CSTR – Constant Density
If the reactor volume is constant and the volumetric flowrates of the inflowand outflow streams are the same, Equation 4.36 reduces to
dcj
dt= 1τ(cjf − cj)+ Rj (4.37)
The parameterτ = VR/Qf
is called the mean residence time of the CSTR.
We refer to this balance as the constant-density case. It is often a goodapproximation for liquid-phase reactions.
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CSTR – Steady State
The steady state of the CSTR is described by setting the time derivative inEquation 4.36 to zero,
0 = Qf cjf −Qcj + RjVR (4.38)
Conversion of reactant j is defined for a steady-state CSTR as follows
xj =Qf cjf −Qcj
Qf cjf(steady state) (4.39)
One can divide Equation 4.38 through by VR to obtain for the constant-densitycase
cj = cjf + Rjτ (steady state, constant density) (4.40)
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Transient behavior of the CSTR
Consider a first-order, liquid-phase reaction in an isothermal CSTR
Ak-→ 2B r = kcA
the feed concentration of A is cAf = 2 mol/L, the residence time of the reactoris τ = 100 min, and the rate constant is k = 0.1 min−1.
1 Find the steady-state concentration of A in the effluent for the given feed.2 Plot the concentration of A versus time for constant feed concentration
cAf = 2 mol/L if the reactor is initially filled with an inert so cA0 = 0 mol/L.3 Plot the concentration of A versus time for constant feed concentration cAf = 2
mol/L if the reactor is initially filled with feed so cA0 = 2 mol/L.
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Transient CSTR Solution. Part 1
Liquid phase: assume the fluid density is constant.
cA = cAf + RAτ
Substituting the production rate RA = −kcA and solving for cA gives thesteady-state concentration
cAs =cAf
1+ kτSubstituting in the numerical values gives
cAs =2 mol/L
1+ (0.1 min−1)(100 min)= 0.182 mol/L
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Parts 2 and 3
dcA
dt= 1τ(cAf − cA
)− kcA (4.41)
cA(0) = cA0
This equation is also separable. The analytical solution is
cA(t) = cA0e−(1/τ+k)t + cAf
1+ kτ
[1− e−(1/τ+k)t
](4.42)
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Parts 2 and 3
0
0.5
1
1.5
2
0 10 20 30 40 50 60 70 80
cA0 = 0
cA0 = 2
cAs = 0.182
c A(t)
(mo
l/L)
t (min)
Both solutions converge to the same steady-state even though the startingconditions are quite different.
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Phenol production in a CSTR
Consider the reaction of cumene hydroperoxide (CHP) to phenol and acetone
(C6H5)C(CH3)2OOH -→ (C6H5)OH+ (CH3)2CO
CHP -→ phenol+ acetone
The reaction is pseudo-first-order
r = kcCHP
Find the reactor volume to achieve 85% conversion of CHP at steady state.The flowrate into the reactor is Qf = 26.9 m3/hr and k = 4.12 hr−1.
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Phenol production
Liquids at 85◦C, so assume constant density and Q = Qf .
cA = cAf + RAτ
RA = −kcA, and solving for the CHP concentration gives
cA =cAf
1+ kτ(4.43)
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Phenol production
The conversion of CHP (for Q = Qf ) is
xA =cAf − cA
cAf= 1− cA
cAf
xA =kτ
1+ kτ
Solving this equation for τ gives
τ = 1k
xA
1− xA
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Phenol production
Substituting the relation τ = VR/Qf and solving for VR gives
VR =Qf xA
k(1− xA)
Substituting in the known values gives the required CSTR volume
VR =(26.9 m3/hr)(0.85)(4.12 hr−1)(0.15)
= 37 m3
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The Semi-Batch Reactor
The semi-batch reactor is a cross between the batch reactor and CSTR.
The semi-batch reactor is initially charged with reactant, like the batch reactor,but allows a feed addition policy while the reaction takes place, like the CSTR.
Normally there is no outflow stream.
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The Semi-Batch Reactor
We set Q = 0 in the CSTR material balance to obtain
d(cjVR
)dt
= Qf cjf + RjVR, j = 1, . . . ,ns (4.44)
One may choose to operate a semi-batch reactor to control the reaction rateor heat release during reaction by slowly adding one of the reactants in thefeed stream.
Compared to the batch reactor, the semi-batch reactor provides morecomplete use of the reactor volume in reactions such as polymerizations thatconvert from lower density to higher density during the course of the reaction.
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Volume Change Upon Reaction
d(cjVR
)dt
= Qf cjf −Qcj + RjVR (4.45)
Equation 4.45 covers both the batch, CSTR and semi-batch reactors,depending on how we specify Qf and Q.
If we multiply Equation 4.45 by the molecular weight of species j and sumover all species we obtain,
d(∑
j cjMjVR)dt
= Qf
∑j
cjf Mj −Q∑
j
cjMj +∑
j
RjMjVR (4.46)
The term∑
j cjMj is simply the mass density of the reactor contents, which wedenote ρ
ρ =ns∑
j=1
cjMj (4.47)
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Volume Change Upon Reaction
The term∑
j cjf Mj is the mass density of the feedstream, ρf .
We know that conservation of mass in chemical reactions implies∑
j RjMj = 0(see Chapter 2). Substitution into Equation 4.46 leads to
d(ρVR)dt
= Qf ρf −Qρ (4.48)
Equation 4.48 is clearly a total mass balance, in which the total mass in thereactor changes in time due to the inflow and outflow of mass.
Notice that chemical reactions play no role in the total mass balance.
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Equation of state for the mixture
If we have a single-phase system at equilibrium, the intensive variables cj , T ,P , completely specify all intensive variables of the system.
In this chapter we consider T and P to be known, fixed quantities. Therefore,the density of the reaction mixture, which is an intensive variable, is known ifthe cj are known.
This relationship is one form of the equation of state for the mixture
ρ = f̃ (T ,P , c1, c2, . . . , cns )
Substituting the definition of density, we can express the equation of state as
f (c1, c2, . . . , cns ) = 0
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Equation of state for the mixture
For example, we could express the equation of state in terms of the partialmolar volumes as ∑
j
cjV j = 1
in which V j is the partial molar volume of component j in the mixture.
The partial molar volumes are functions of T , P and cj .
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Equation of state for the mixture — Ideal mixture
If we assume an ideal mixture, this reduces to∑j
cjV ◦j = 1, ideal mixture
in which V ◦j is the specific volume of pure component j, which is a function ofonly T and P .
We assume that a thermodynamic equation of state is valid even when thereactor is not at equilibrium.
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Constant density
Because the reaction mixture density, ρ, is independent of composition, itdoes not vary with time either and we can set it to the feed value,
ρ = ρf
The total mass balance then reduces to
dVR
dt= Qf −Q (4.51)
which is sometimes referred to as a “volume balance.”
This terminology should be avoided.
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Constant density
dVR
dt= Qf −Q
Batch reactor. For the batch reactor, Q = Qf = 0. We can therefore concludefrom Equation 4.51 that a batch reactor with constant density has constantvolume.
CSTR (dynamic and steady state). If the outflow of the CSTR is regulated sothat the CSTR has constant volume, then we can conclude from Equation 4.51that Q = Qf .
Semi-batch reactor. In the semi-batch reactor, the reactor is filled duringoperation so Qf is specified and positive for some time and Q = 0. Thesolution to Equation 4.51 then determines the change in volume of thereactor during the filling operation.
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Nonconstant density
Unknowns.
In the general case, consider the following variables to fullydetermine the state of the reactor: T ,P ,nj ,VR.We also require the value of Q to specify the right-hand sidesof the material balances.The set of unknowns is nj ,VR,Q.We therefore have ns + 2 unknowns.
Equations.
We have the ns equations from the component mole balances.The equation of state provides one additional equation.The final equation is provided by a statement of reactoroperation.
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Nonconstant density – reactor operation
1 Constant-volume reactor. The constant-volume reactor can be achieved byallowing overflow of the reactor to determine flowrate out of the reactor. Inthis situation, VR is specified as the additional equation.
2 Constant-mass reactor. The constant-mass reactor can be achieved if adifferential pressure measurement is used to control the flowrate out of thereactor and the reactor has constant cross-sectional area. In this situationρVR is specified as the additional equation.
3 Flowrate out of the reactor is specified. This type of operation may beachieved if the flowrate out of the reactor is controlled by a flow controller. Inthis case Q(t) is specified. A semi-batch reactor is operated in this way withQ = 0 until the reactor is filled with the reactants.
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Nonconstant density – reactor operation
See the text for the derivation.
dVR
dt= Qf
∑j fjcjf∑j fjcj
−Q +∑
i ∆firiVR∑j fjcj
(4.53)
in which fj is
fj =∂f∂cj
and ∆fi is
∆fi =∑
j
νijfj =∑
j
νij∂f∂cj
which is a change in a derivative property upon reaction.
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Nonconstant density – idea mixture
For the ideal mixture we have f (cj) =∑
j cjV ◦j − 1 = 0.
fj = V ◦j
the pure component specific volumes
The ∆fi are given by∆fi = ∆V ◦i
the change in specific volume upon reaction i.
So the reactor volume can be calculated from
dVR
dt= Qf −Q +
∑i
∆V ◦i riVR
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Nonconstant density
Unknowns (ns + 2): VR ,Q,nj , j = 1, . . . ,ns
Component balances:dnjdt = Qf cjf −Qcj + Rj VR , j = 1, . . . ,ns
Defined quantities: nj = cj VR ρ =∑
j cj Mj ∆V◦i =∑
j νij V◦j
(i) constant density: ρ = ρ0 (ii) ideal mixture:∑
j cj V◦j = 1
1. vol VR = VR0 Q = Qf VR = VR0 Q = Qf +∑
i ∆V◦i ri VR
2. mass VR = VR0 Q = QfdVRdt = Qf (1− ρf /ρ)+
∑i ∆V◦i ri VR Q = Qf ρf /ρ
3. QdVRdt = Qf −Q Q specified
dVRdt = Qf −Q +
∑i ∆V◦i ri VR Q specified
Table 4.1: Reactor balances for constant-density and ideal-mixture assumptions.
74 / 153
Nonconstant density
Unknowns (ns + 2): VR ,Q,nj , j = 1, . . . ,ns
Component balances:dnjdt = Qf cjf −Qcj + Rj VR , j = 1, . . . ,ns
Defined quantities: nj = cj VR ρ =∑
j cj Mj ∆fi =∑
j νij∂f∂cj
Equation of state: f (c1 , c2 , . . . , cns ) = 0
DAEs ODEs
1. vol VR = VR0 f (cj ) = 0 VR = VR0 Q = Qf
∑j fj cjf∑j fj cj
+∑
i ∆fi ri VR∑j fj cj
2. mass ρVR = ρ0VR0 f (cj ) = 0dVRdt = Qf
∑j fj cjf∑j fj cj
−Q +∑
i ∆fi ri VR∑j fj cj
Q = Qf ρf /ρ
3. Q Q specified f (cj ) = 0dVRdt = Qf
∑j fj cjf∑j fj cj
−Q +∑
i ∆fi ri VR∑j fj cj
Q specified
Table 4.2: Reactor balances for general equation of state.
75 / 153
Semi-batch polymerization
Consider a solution polymerization reaction, which can be modeled as afirst-order, irreversible reaction
Mk-→ P r = kcM
A 20 m3 semi-batch reactor is initially charged with solvent and initiator tohalf its total volume.
A pure monomer feed is slowly added at flowrate Qf 0 = 1 m3/min to fill thereactor in semi-batch operation to control the heat release.
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Semi-batch polymerization
Consider two cases for the subsequent reactor operation.1 The monomer feed is shut off and the reaction goes to completion.2 The monomer feed is adjusted to keep the reactor filled while the reaction goes to
completion.
Calculate the total polymer mass production, and the percentage increase inpolymer production achieved in the second operation.
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The physical properties
You may assume an ideal mixture
The densities of monomer and polymer are
ρM = 800 kg/m3 ρP = 1100 kg/m3
The monomer molecular weight is MM = 100 kg/kmol
The rate constant is k = 0.1 min−1.
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Semi-batch polymerization
While the reactor is filling, the monomer mole balance is
d(cMVR)dt
= Qf 0cMf − kcMVR
in which cMf = ρM/MM is given, and Qf = Qf 0 is constant during the fillingoperation.
We denote the total number of moles of monomer by M = cMVR, and can writethe monomer balance as
dMdt= Qf 0cMf − kM (4.54)
M(0) = 0
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Semi-batch polymerization
For an ideal mixture, the volume is given by
dVR
dt= Qf 0 +∆VkM (4.55)
VR(0) = 10 m3
in which ∆V = (1/ρP − 1/ρM)MM
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The polymer mass production
To compute the polymer mass, we note from the stoichiometry that the massproduction rate of polymer R̃P is
R̃P = −RMMM
The mass balance for total polymer P̃ is given by
dP̃dt= R̃pVR = kcMMMVR = (kMM)M (4.56)
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Semi-batch polymerization
The text solves this problem analytically. Instead, let’s solve it numerically.
Let t1 be the time that the reactor fills.
We need an ODE solver that is smart enough to stop when the reactor fills,because we do not know this time t1. The ODE solver needs to find it for us.
dasrt is an ODE solver with the added capability to find the time at whichsome event of interest occurs.
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Finding the time for filling the reactor
The ODE solver finds the time at which VR = 20 m3
t1 = 11.2 min
Note the reactor would have filled in 10 min if the density were constant.
The extra time reflects the available volume created by converting some ofthe monomer to polymer during filling.
After t1 we consider the two operations.
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Operation 1.
In the first operation, Qf = 0 after t1.
Notice the reactor volume decreases after t1 because ∆V is negative.
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Semi-batch polymerization
0
5
10
15
20
0 10 20 30 40 50
VR(m
3)
2
1
time (min)
Figure 4.15: Semi-batch reactor volume for primary monomer addition (operation 1) andprimary plus secondary monomer additions (operation 2).
-0.2
0
0.2
0.4
0.6
0.8
1
0 10 20 30 40 50
Qf(m
3/m
in)
2
1
time (min)
Figure 4.16: Semi-batch reactor feed flowrate for primary monomer addition (operation 1)and primary plus secondary monomer additions (operation 2).
0
1000
2000
3000
4000
5000
6000
0 10 20 30 40 50
mo
no
mer
(kg
)
2
1
time (min)
Figure 4.17: Semi-batch reactor monomer content for primary monomer addition (operation1) and primary plus secondary monomer additions (operation 2).
0
2000
4000
6000
8000
10000
12000
0 10 20 30 40 50
po
lym
er(k
g)
2
1
time (min)
Figure 4.18: Semi-batch reactor polymer content for primary monomer addition (operation1) and primary plus secondary monomer additions (operation 2).
85 / 153
Operation 2.
Because the reactor volume is constant, we can solve Equation 4.55 for thefeed flowrate during the secondary monomer addition
Qf = −∆VkM
Operation 2 is also shown in the figures.
Notice the final polymer production is larger in operation 2 because of theextra monomer addition.
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Polymer production rate
We can perform an independent, simple calculation of the total polymer inoperation 2. Useful for debugging the computation.
In operation 2, 10 m3 of polymer are produced because in an ideal mixture,the volumes are additive. Therefore
P̃2 = (VR − VR0)ρP = 10 m3 × 1100 kg/m3 = 11000 kg
in good agreement with the long-time solution for operation 2.
The increase in production rate is
P̃2 − P̃1
P̃1× 100% = 22.5%
By using the volume of the reactor more efficiently, the total polymerproduction increases 22.5%.
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The Plug-Flow Reactor (PFR)
Plug flow in a tube is an ideal-flow assumption in which the fluid is well mixedin the radial and angular directions.
The fluid velocity is assumed to be a function of only the axial position in thetube.
Plug flow is often used to approximate fluid flow in tubes at high Reynoldsnumber. The turbulent flow mixes the fluid in the radial and angulardirections.
Also in turbulent flow, the velocity profile is expected to be reasonably flat inthe radial direction except near the tube wall.
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Thin Disk Volume Element
Given the plug-flow assumption, it is natural to take a thin disk for the reactorvolume element
Q
cj
Q(z +∆z)
cj(z +∆z)
Q(z)
cj(z)
Qf
cjf
z
Rj∆V
z +∆z
︷ ︸︸ ︷
89 / 153
Thin Disk Volume Element
Expressing the material balance for the volume element
∂(cj∆V
)∂t
= cjQ∣∣
z − cjQ∣∣
z+∆z + Rj∆V
Dividing the above equation by ∆V and taking the limit as ∆V goes to zeroyields,
∂cj
∂t︸ ︷︷ ︸accumulation
= − ∂(cjQ
)∂V︸ ︷︷ ︸
convection
+ Rj︸︷︷︸reaction
(4.64)
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Length or volume as independent variable
If the tube has constant cross section, Ac , then velocity, v , is related tovolumetric flowrate by v = Q/Ac , and axial length is related to tube volume byz = V/Ac ,
Equation 4.64 can be rearranged to the familiar form [1, p.584]
∂cj
∂t= −∂
(cjv
)∂z
+ Rj (4.65)
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Steady-State Operation
Setting the time derivative in Equation 4.64 to zero gives,
d(cjQ)dV
= Rj (4.66)
The product cjQ = Nj is the total molar flow of component j. One also canexpress the PFR mole balance in terms of the molar flow,
dNj
dV= Rj (4.67)
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Volumetric Flowrate for Gas-Phase Reactions
To use Equation 4.67 for designing a gas-phase reactor, one has to be able torelate the volumetric flowrate, Q, to the molar flows, Nj , j = 1,2, . . . ,ns.
The important piece of information tying these quantities together is, again,the equation of state for the reaction mixture, f (T ,P , cj) = 0.
Because the molar flow and concentration are simply related,
Nj = cjQ (4.68)
the equation of state is also a relation between temperature, pressure, molarflows, and volumetric flowrate.
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Ideal Gas Equation of State
The ideal-gas equation of state, c = P/RT , can be stated in terms of molarconcentrations, cj , as ∑
j
cj =P
RT
In terms of molar flows, the equation of state is∑j Nj
Q= P
RT
One can solve the previous equation for the volumetric flowrate,
Q = RTP
∑j
Nj (4.69)
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Ideal Gas Equation of State
To evaluate the concentrations for use with the reaction rate expressions, onesimply rearranges Equation 4.68 to obtain
cj =Nj
Q= P
RTNj∑j Nj
(4.70)
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Volumetric Flowrate for Liquid-Phase Reactions
Consider the equation of state for a liquid-phase system to be arranged in theform
ρ = f (T ,P , cj)
The mass density is related to the volumetric flowrate and total mass flow,M =
∑j NjMj , via
M = ρQ (4.71)
Multiplying Equation 4.67 by Mj and summing on j produces
dMdV
= 0, M(0) = Mf
in which Mf is the feed mass flowrate.
The total mass flow in a PFR is constant.
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Volumetric Flowrate for Liquid-Phase Reactions
We can solve for the volumetric flowrate by rearranging Equation 4.71
Q = Mf
ρ(4.72)
If the liquid density is considered constant, ρ = ρf , then
Q = Qf , constant density (4.73)
and the volumetric flowrate is constant and equal to the feed value.
Equation 4.73 is used often for liquid-phase reactions.
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Volumetric Flowrate for Liquid-Phase Reactions
If we denote the time spent in the tube by τ = V/Q, if Q is constant, we canrewrite Equation 4.66 as
dcj
dτ= Rj , constant flowrate (4.74)
which is identical to the constant-volume batch reactor.
For the constant-flowrate case, the steady-state profile in a PFR starting froma given feed condition is also the transient profile in a batch reactor startingfrom the equivalent initial condition.
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Single Reaction Systems – Changing flowrate in a PFR
A pure vapor stream of A is decomposed in a PFR to form B and C
Ak-→ B+ C
Determine the length of 2.5 cm inner-diameter tube required to achieve 35%conversion of A. The reactor temperature is 518◦C and the pressure is2.0 atm. Assume the pressure drop is negligible.
The reaction rate is first order in A, k = 0.05 sec−1 at the reactor temperature,and the feed flowrate is 35 L/min.
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Changing flowrate in a PFR
The mole balance for component A gives
dNA
dV= RA
The production rate of A is RA = −r = −kcA.
Substituting the production rate into the above equation gives,
dNA
dV= −kNA/Q (4.75)
The volumetric flowrate is not constant, so we use Equation 4.69, whichassumes an ideal-gas equation of state,
Q = RTP(NA +NB +NC) (4.76)
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Changing flowrate in a PFR
The ideal-gas assumption is reasonable at this reactor temperature andpressure.
One can relate the molar flows of B and C to A using the reactionstoichiometry. The mole balances for B and C are
dNB
dV= RB = r
dNC
dV= RC = r
Adding the mole balance for A to those of B and C gives
d (NA +NB)dV
= 0d (NA +NC)
dV= 0
The stoichiometry does not allow the molar flow NA +NB or NA +NC to changewith position in the tube.
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Changing flowrate in a PFR
Because NA +NB and NB +NC are known at the tube entrance, one can relateNB and NC to NA,
NA +NB = NAf +NBf
NA +NC = NAf +NCf
Rearranging the previous equations gives,
NB = NAf +NBf −NA
NC = NAf +NCf −NA
Substituting the relations for NB and NC into Equation 4.76 gives
Q = RTP
(2NAf +NBf +NCf −NA
)
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Changing flowrate in a PFR
Because the feed stream is pure A, NBf = NCf = 0, yielding
Q = RTP
(2NAf −NA
)Substituting this expression in Equation 4.75 gives the final mole balance,
dNA
dV= −k
PRT
NA
2NAf −NA
The above differential equation can be separated and integrated,∫ NA
NAf
2NAf −NA
NAdNA =
∫ V
0− kP
RTdV
103 / 153
Changing flowrate in a PFR
Performing the integration gives,
2NAf ln(NA/NAf
)+(NAf −NA
)= − kP
RTV
The conversion of component j for a plug-flow reactor operating at steadystate is defined as
xj =Njf −Nj
Njf
Because we are interested in the V corresponding to 35% conversion of A, wesubstitute NA = (1− xA)NAf into the previous equation and solve for V,
V = −RTkP
NAf [2 ln(1− xA)+ xA]
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Changing flowrate in a PFR
Because Qf = NAf RT /P is given in the problem statement and the tube lengthis desired, it is convenient to rearrange the previous equation to obtain
z = − Qf
kAc[2 ln(1− xA)+ xA]
Substituting in the known values gives
z = −(
35× 103 cm3/min0.05 sec−1 60 sec/min
)(4
π(2.5 cm)2
)[2 ln(1− .35)+ .35]
z = 1216 cm = 12.2 m
105 / 153
Multiple-Reaction Systems
The modeler has some freedom in setting up the material balances for aplug-flow reactor with several reactions.
The most straightforward method is to write the material balance relation forevery component,
dNj
dV= Rj , j = 1,2, . . . ,ns
Rj =nr∑
i=1
νijri , j = 1,2, . . . ,ns
The reaction rates are expressed in terms of the species concentrations.
The cj are calculated from the molar flows with Equation 4.68
Q is calculated from Equation 4.69, if an ideal-gas mixture is assumed.
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Benzene pyrolysis in a PFR I
Hougen and Watson [3] analyzed the rate data for the pyrolysis of benzene bythe following two reactions.
Diphenyl is produced by the dehydrogenation of benzene,
2C6H6
k1-⇀↽-k−1
C12H10 +H2
2B -⇀↽- D+H
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Benzene pyrolysis in a PFR
Triphenyl is formed by the secondary reaction,
C6H6 + C12H10
k2-⇀↽-k−2
C18H14 +H2
B+D -⇀↽- T+H
The reactions are assumed to be elementary so that the rate expressions are
r1 = k1
(c2
B −cDcH
K1
)r2 = k2
(cBcD −
cT cH
K2
)(4.79)
108 / 153
Benzene pyrolysis in a PFR
Calculate the tube volume required to reach 50% total conversion of thebenzene for a 60 kmol/hr feed stream of pure benzene.
The reactor operates at 1033K and 1.0 atm.
Plot the mole fractions of the four components versus reactor volume.
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Benzene pyrolysis in a PFR
The rate and equilibrium constants at T = 1033K and P = 1.0 atm are givenin Hougen and Watson,
k1 = 7× 105 L/mol · hr
k2 = 4× 105 L/mol · hr
K1 = 0.31
K2 = 0.48
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Benzene pyrolysis in a PFR
The mole balances for the four components follow from the stoichiometry,
dNB
dV= −2r1 − r2
dND
dV= r1 − r2
dNH
dV= r1 + r2
dNT
dV= r2
The initial condition for the ODEs are NB(0) = NBf andND(0) = NH(0) = NT (0) = 0.
111 / 153
Benzene pyrolysis in a PFR
The total molar flux does not change with reactor volume.
Q = RTP
NBf (4.80)
The rate expressions are substituted into the four ODEs and they are solvednumerically.
The total conversion of benzene, xB = (NBf −NB)/NBf , is plotted versusreactor volume in Figure 4.20.
A reactor volume of 404 L is required to reach 50% conversion. Thecomposition of the reactor versus reactor volume is plotted in Figure 4.21.
112 / 153
0
0.1
0.2
0.3
0.4
0.5
0.6
0 200 400 600 800 1000 1200 1400 1600
xB
V (L)
Figure 4.20: Benzene conversion versus reactor volume.
113 / 153
0
0.2
0.4
0.6
0.8
1
0 200 400 600 800 1000 1200 1400 1600
yB
yH
yT
yD
yj
V (L)
Figure 4.21: Component mole fractions versus reactor volume.
114 / 153
Ethane pyrolysis in the presence of NO
See the text for another worked PFR example.
115 / 153
Some PFR-CSTR Comparisons
We have two continuous reactors in this chapter: the CSTR and the PFR.
Let’s compare their steady-state efficiencies in converting reactants toproducts.
For simplicity, consider a constant-density, liquid
Ak-→ B r = kcn
A
For this situation, the steady-state PFR material balance is given byEquation 4.74
dcA
dτ= −r(cA)
116 / 153
Some PFR-CSTR Comparisons
We rearrange and solve for the time required to change from the feedcondition cAf to some exit concentration cA
τ =∫ cA
cAf
1r(c′A)
dc′A
The area under the curve 1/r(c′A) is the total time required to achieve thedesired concentration change.
1r(c′A)
cAfcAc′A
PFR
CSTR
117 / 153
Some PFR-CSTR Comparisons
To achieve this same concentration change in the CSTR, we start withEquation 4.40, and solve for τ giving
τ = cAf − cA
r(cA)
This result also can be interpreted as an area. Notice that this area is theheight, 1/r(cA), times the width, cAf − cA, of the rectangle.
1r(c′A)
cAfcAc′A
PFR
CSTR
118 / 153
Some PFR-CSTR Comparisons
If 1/r(cA) is a decreasing function of cA, or, equivalently, r(cA) is anincreasing function of cA, to achieve the same conversion, the PFR time (orvolume, VR = Qf τ) is less than the CSTR time (volume).
The PFR reaction rate varies with length. The rate is high at the entrance tothe tube where the concentration of A is equal to the feed value, anddecreases with length as the concentration drops. At the exit of the PFR, therate is the lowest of any location in the tube.
Now considering that the entire volume of the CSTR is reacting at this lowestrate of the PFR, it is intuitively obvious that more volume is required for theCSTR to achieve the same conversion as the PFR.
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Some PFR-CSTR Comparisons
If the reaction order is positive (the usual case), the PFR is more efficient. Ifthe reaction order is negative, the CSTR is more efficient.
1r(c′A)
cAfcAc′A
CSTR
PFR
120 / 153
The PFR versus CSTR with separation
The PFR achieves higher conversion than an equivalent volume CSTR for theirreversible reaction with first-order kinetics
A -→ B r = kcA
Consider the case in which we add separation.
Find a single CSTR and separator combination that achieves the sameconversion as the PFR.
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The PFR versus CSTR with separation
The issue is to increase the CSTR achievable conversion using separation.
Education in chemical engineering principles leads one immediately toconsider recycle of the unreacted A as a means to increase this conversion.
122 / 153
The PFR versus CSTR with separation
NA0 NA1 NA2 NA
NA0 NA
αNA2αNA2
pure B
VR
VR
In the text, we show how to find the recycle flowrate so this system achievesthe PFR conversion.
123 / 153
CSTR Equivalence Principle.
This example was motivated by a recent result of Feinberg and Ellison calledthe CSTR Equivalence Principle of Reactor-Separator Systems [2].
This surprising principle states:
For a given reaction network with ni linearly independent reactions, anysteady state that is achievable by any reactor-separator design with totalreactor volume V is achievable by a design with not more than ni+1 CSTRs,also of total reactor volume V . Moreover the concentrations, temperaturesand pressures in the CSTRs are arbitrarily close to those occurring in thereactors of the original design.
124 / 153
Stochastic Simulation of Chemical Reactions
We wish to introduce next a topic of increasing importance to chemicalengineers, stochastic (random) simulation.
In stochastic models we simulate quite directly the random nature of themolecules.
We will see that the deterministic rate laws and material balances presented inthe previous sections can be captured in the stochastic approach by allowingthe numbers of molecules in the simulation to become large.
The stochastic modeling approach is appropriate if the random nature of thesystem is one of the important features to be captured in the model.
These situations are becoming increasingly important to chemical engineersas we explore reactions at smaller and smaller length scales.
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Stochastic Simulation of Chemical Reactions
For example, if we are modeling the chemical transformation by reaction ofonly a few hundreds or thousands of molecules at an interface, we may wantto examine explicitly the random fluctuations taking place.
In biological problems, we often consider the interactions of only severalhundred or several thousand protein molecules and cells.
In sterilization problems, we may wish to model the transient behavior untilevery last organism is eliminated.
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Stochastic Simulation of Chemical Reactions
Assume we have only a hundred molecules moving randomly in the gas phase
Ak1-→ B
Bk2-→ C
in a constant-volume batch reactor.
The probability of reaction is assumed proportional to the
r1 = k1xA r2 = k2xB
in which xj is the number of component j molecules in the reactor volume.
Note xj is an integer, unlike the deterministic model’s cj , which is real.
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Stochastic Simulation of Chemical Reactions
The basic idea of the Gillespie algorithm is to: (i) choose randomly the time atwhich the next reaction occurs, and (ii) choose randomly which reactions occurs atthat time.
1 Initialize. Set integer counter n to zero. Set the initial species numbers,xj(0), j = 1, . . .ns. Determine stoichiometric matrix ν and reaction probabilitylaws (rate expressions)
ri = kih(xj)
for all reactions.
2 Compute reaction probabilities, ri = kih(xj). Compute total reactionprobability rtot =
∑i ri .
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Stochastic Simulation of Chemical Reactions
1 Select two random numbers, p1,p2, from a uniform distribution on theinterval (0,1). Let the time interval until the next reaction be
t̃ = − ln(p1)/rtot (4.85)
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Stochastic Simulation of Chemical Reactions
1 Determine reaction m to take place in this time interval. The idea here is topartition the interval (0,1) by the relative sizes of each reaction probabilityand then “throw a dart” at the interval to pick the reaction that occurs. In thismanner, all reactions are possible, but the reaction is selected in accord withits probability.
p2
r1r1+r2
r2r1+r20 1
130 / 153
Stochastic Simulation of Chemical Reactions
1 Update the simulation time t(n + 1) = t(n)+ t̃. Update the species numbersfor the single occurrence of the mth reaction via
xj(n + 1) = xj(n)+ νmj , j = 1, . . .ns
Let n = n + 1. Return to Step 2.
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Stochastic Simulation of Chemical Reactions
If rtot is the total probability for reaction, e−rtot t̃ is the probability that areaction has not occurred during time interval t̃.
We will derive this fact in Chapter 8 when we develop the residence-timedistribution for a CSTR.
The next figure shows the results of this algorithm when starting withxA = 100 molecules.
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Stochastic Simulation of Chemical Reactions
0
20
40
60
80
100
0 1 2 3 4 5
xA
xB
xC
xj
t
133 / 153
Stochastic Simulation of Chemical Reactions
Notice the random aspect of the simulation gives a rough appearance to thenumber of molecules versus time, which is quite unlike any of thedeterministic simulations.
Because the number of molecules is an integer, the simulation is actuallydiscontinuous with jumps between simulation times.
But in spite of the roughness, we already can make out the classic behavior ofthe series reaction: loss of starting material A, appearance and thendisappearance of the intermediate species B, and slow increase in finalproduct C.
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Stochastic Simulation of Chemical Reactions
Next we explore the effect of increasing the initial number of A molecules ona single simulation. The results for 1000 and 4000 initial A molecules areshown in the next figures.
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Stochastic Simulation of Chemical Reactions
0
200
400
600
800
1000
0 1 2 3 4 5
xA
xB
xC
xj
t
136 / 153
Stochastic Simulation of Chemical Reactions
0
800
1600
2400
3200
4000
0 1 2 3 4 5
xA
xB
xC
xj
t
137 / 153
Stochastic Simulation of Chemical Reactions
We see the random fluctuations become less pronounced. Notice that evenwith only 4000 starting molecules, the results compare very favorably withthe deterministic simulation shown previously.
Another striking feature of the stochastic approach is the trivial level ofprogramming effort required to make the simulations.
The biggest numerical challenge is producing the pseudorandom numbersand many well-developed algorithms are available for that task.
The computational time required for performing the stochastic simulationmay, however, be large.
138 / 153
Hepatitis B virus modeling
139 / 153
Hepatitis B virus modeling
nucleotidescccDNA−−−−−−→ rcDNA
nucleotides+ rcDNA −−−−−−→ cccDNA
amino acidscccDNA−−−−−−→ envelope
cccDNA −−−−−−→ degraded
envelope −−−−−−→ secreted or degraded
rcDNA+ envelope −−−−−−→ secreted virus
140 / 153
Hepatitis B virus modeling
The reaction rates and production rates for Reactions 4.86–4.91 are given by
r1
r2
r3
r4
r5
r6
=
k1xA
k2xB
k3xA
k4xA
k5xC
k6xBxC
RA
RB
RC
= r2 − r4
r1 − r2 − r6
r3 − r5 − r6
(4.94)
in which A is cccDNA, B is rcDNA, and C is envelope.
141 / 153
Hepatitis B virus modeling
Assume the systems starts with a single cccDNA molecule and no rcDNA andno envelope protein, and the following rate constants[
xA xB xC
]T=[
1 0 0]T
(4.92)
kT =[
1 0.025 1000 0.25 2 7.5× 10−6]
(4.93)
142 / 153
Average stochastic is not deterministic. I
0
5
10
15
20
25
0 50 100 150 200
cccD
NA
deterministic
average stochastic
t (days)
0
50
100
150
200
250
0 50 100 150 200
rcD
NA deterministic
average stochastic
t (days)
0
2000
4000
6000
8000
10000
0 50 100 150 200
enve
lop
e deterministic
average stochastic
t (days)
143 / 153
Hepatitis B virus modeling
0
5
10
15
20
25
30
35
0 50 100 150 200
cccD
NA
deterministic
stochastic 1
stochastic 2
t (days)
Figure 4.35: Species cccDNA versus time for hepatitis B virus model; two representativestochastic trajectories.
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Hepatitis B virus modeling
The simulation of the deterministic model and an average of 500 stochasticsimulations are not the same.
Figure 4.35 shows two representative stochastic simulations for only thecccDNA species.
Notice the first stochastic simulation does fluctuate around the deterministicsimulation as expected.
The second stochastic simulation, however, shows complete extinction of thevirus. That is another possible steady state for the stochastic model.
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Average stochastic is not deterministic.
In fact, it occurs for 125 of the 500 simulations. So the average stochasticsimulation consists of 75% trajectories that fluctuate about the deterministictrajectory and 25% trajectories that go to zero.
0
5
10
15
20
25
0 50 100 150 200
cccD
NA
deterministic
average stochastic
t (days)
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Summary
We have introduced four main reactor types in this chapter.
the batch reactor
the continuous-stirred-tank reactor (CSTR)
the semi-batch reactor
the plug-flow reactor (PFR).
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Summary
BATCHd(cj VR)
dt= Rj VR (4.95)
constant volumedcjdt
= Rj (4.96)
CSTRd(cj VR)
dt= Qf cjf −Qcj + Rj VR (4.97)
constant densitydcjdt
=1τ(cjf − cj )+ Rj (4.98)
steady state cj = cjf + Rjτ (4.99)
SEMI-BATCHd(cj VR)
dt= Qf cjf + Rj VR (4.100)
PFR∂cj∂t
= −∂(cj Q)
∂V+ Rj (4.101)
steady stated(cj Q)
dV= Rj (4.102)
constant flowratedcjdτ
= Rj , τ = V/Qf (4.103)
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Summary
We also have introduced some of the basic reaction-rate expressions.
first order, irreversible
first order, reversible
second order, irreversible
nth order, irreversible
two first-order reactions in series
two first-order reactions in parallel
two second-order, reversible reactions
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Summary
We developed the equations required to compute the volume of the reactor ifthere is a significant volume change upon reaction. We require an equation ofstate for this purpose.
Several of these simple mass balances with basic rate expressions weresolved analytically.
In the case of multiple reactions with nonlinear rate expressions (i.e., notfirst-order reaction rates), the balances must be solved numerically.
A high-quality ordinary differential equation (ODE) solver is indispensable forsolving these problems.
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Summary
We showed that the PFR achieves higher conversion than the CSTR of thesame volume if the reaction rate is an increasing function of a componentcomposition (n > 0 for an nth-order rate expression).
Conversely, the CSTR achieves higher conversion than the same-volume PFR ifthe rate is a decreasing function of a component composition (n < 0).
Finally, we introduced stochastic simulation to model chemical reactionsoccurring with small numbers of molecules.
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Summary
The stochastic model uses basic probability to compute reaction rate. A givenreaction’s probability of occurrence is assumed proportional to the number ofpossible combinations of reactants for the given stoichiometry.
Two pseudorandom numbers are chosen to determine: (i) the time of the nextreaction and (ii) the reaction that occurs at that time.
The smooth behavior of the macroscopic ODE models is recovered by therandom simulations in the limit of large numbers of reacting molecules.
With small numbers of molecules, however, the average of the stochasticsimulation does not have to be equal to the deterministic simulation. Wedemonstrated this fact with the simple, nonlinear hepatitis B virus model.
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References I
R. B. Bird, W. E. Stewart, and E. N. Lightfoot.
Transport Phenomena.John Wiley & Sons, New York, second edition, 2002.
M. Feinberg and P. Ellison.
General kinetic bounds on productivity and selectivity in reactor-separator systems of arbitrary design: I.Principles.Ind. Eng. Chem. Res., 40(14):3181–3194, 2001.
O. A. Hougen and K. M. Watson.
Chemical Process Principles. Part Three: Kinetics and Catalysis.John Wiley & Sons, New York, 1947.
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