the lung institute of western australia &caarr postgraduate research for the six million...
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![Page 1: The Lung Institute of Western Australia &CAARR Postgraduate Research For the six million Australians who struggle to take a breath, LIWA offers support](https://reader038.vdocuments.us/reader038/viewer/2022103111/551695f4550346a25b8b50d8/html5/thumbnails/1.jpg)
The Lung Institute of Western Australia &CAARR
Postgraduate ResearchFor the six million
Australians who struggle to take a
breath, LIWA offers support and hope for a
healthier future.
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Why Research Lung Disease
6 Million Australians struggle to breathe.
60 x
Melbourne Cricket Ground
Almost one in three Australians
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Why lung disease?
A major problem for Australia; • Asthma – Australia &NZ highest in world• Emphysema – 4th most common cause of death • Lung cancer – Most lethal of all cancers• Cystic fibrosis – most common genetic disease• Pneumonia – a major problem for the elderly &
& infection indigenous people• Bronchiectasis – an emerging epidemic in Australia• Mesothelioma – asbestos & WA• Pul. Hypertension – poorly recognised
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Our Research Philosophy
Address the breadth of lung disease using the best research tools available
• Bridge lab to clinic• Encourage a multidisciplinary
approach • Encourage networking & collaboration• Ensure mutual recognition of the
merits of both Basic and Clinical science
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LIWA’s Aims
• Support high quality research • Support young scientists• Educational & scientific
resource for the community• Improve well-being of patients• Be an advocacy group for
better lung health
Cadets, Thomas and Sarah
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LIWA’s Research Units
Biological Sciences Research
Clinical Sciences Research
• Tissue Repair, Inflammation & Cancer• Molecular Genetics• Pleural Disease • Stem Cell
• Clinical Trials Unit• Pul. Vascular Disease• Physiotherapy• Cardiothoracic Surgery• Cystic Fibrosis /Bronchiectasis
World Class Researchers
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LIWA’s Research Units
Biological Sciences Research
• Tissue Repair, Inflammation & Cancer• Head – Steve Mutsaers
• Research Activities• Micro RNA and mesothelioma• Sonic Hedgehog signalling in
mesothelioma & lung cancer• STAT signalling in pulmonary fibrosis• Stem cells in mesothelial tissue repair• Role of kinins in tumour angiogenesis
Funding• NH&MRC• Dust Diseases Board of NSW
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LIWA’s Research Units
Biological Sciences Research
• Molecular Genetics Unit• Head – Phil Thompson
• Research Activities• Antisense therapies for Asthma• Pharmacogenetics of Asthma medications• Gene regulation & role of splice variants as
regulators of inflammatory pathways• Candidate gene polymorphisms• GWAS for asthma in national/international
consortia
FundingNH&MRC CRC for Asthma and Airways
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LIWA’s Research Units
Biological Sciences Research
• Pleural Disease Unit• Head – Gary Lee
• Research Activities• Development of biomarkers of
mesothelioma• Mechanisms of pleural effusion
development • Better management of Pleural effusion• Mechanisms underlying pleural infection
FundingWelcome Trust, MRC UKRaine; LIWA; State Government
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LIWA’s Research Units
Biological Sciences Research
• Stem Cell Unit• Head – Yuben Moodley
• Research Activities• Use of mesenchymal stem cells in COPD• Animal studies on mesenchymal stem cells
for lung repair • Development of a tracheal explant model for
assessing injury repair pathways
FundingRPH UWA
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LIWA’s Research UnitsClinical Sciences Research
• Clinical Trials Unit Largest respiratory trials unit in Australia
• Pul. Vascular Disease & Transplantation Recognised internationally for pioneering work on early detection of Pul Hypertenison
• Physiotherapy Lead group in developing assessments of breathlessness
• Cystic Fibrosis /Bronchiectasis New unit looking at inflammatory mediators in these diseases and new treatments
• Cardiothoracic Surgery Prevention of ischaemic injury during surgery
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Funding
LIWA derives its income from diverse sources.
EXPENSES
71%
18%
11%
SALARIES
RESEARCH CONSUMABLES
ADMINISTRATION
INCOME
2%
40%
23%
11%
23%
1%
0%
INTERNATIONAL GRANTS NATIONAL GRANTS LOCAL GRANTS CONTRACTS
CLINICAL TRIALS DONATIONS MEMBERSHIPS
Over 70% of our expenditure is on research.
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LIWA RESEARCH
• Is multifaceted, bridges lab to clinic• Has national and international
collaborations• Welcomes partnering in research
either at the laboratory or patient level