the life$sciences$ institutelsi-dev.sites.olt.ubc.ca/files/2014/11/lsi-all... ·...
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THE LIFE SCIENCES INSTITUTE Pieter Cullis, Professor & Director
The Life Sciences Institute
Life Sciences Institute: Vision
1. Maintain and improve excellence in basic life science research
2. Achieve global compe@@veness in transla@onal research to the clinic by pursuing personalized medicine opportuni@es
3. Achieve global compe@@veness in commercializa@on ac@vi@es
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The Life Sciences Institute
Life Sciences Institute: Overview & Facts
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The Life Sciences Institute
Vision for the LSI 2018: Best in Canada and Amongst Top Ten in World for Integrated Disease-‐Related Research
q Maintain and improve #1 ranking in Canada for basic life science research
q Achieve global compe::veness in transla:onal research to clinic o Raise $50M to pursue transla:onal research through personalized medicine
opportuni:es
q Achieve global compe::veness in commercializa:on ac:vi:es o At least 5 spinoffs and/or 5 technologies licensed out per year
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The Life Sciences Institute
What Have We Done So Far?
q Maintain and improve #1 ranking in Canada for basic life science research o Established Academic CommiEee o New LSI website o Omics Portal launched o CFI applica:on under review
q Achieve global compe::veness in transla:onal research to clinic o Iden:fied 13 large Personalized Medicine projects
§ Business plans wriEen for 5 projects § First two projects funded and ini:ated § Funding discussions underway for two more projects
o Molecular You -‐ Preven:ve Health project o Personalized Medicine Summit June 7-‐9, 2015
§ Personalized Medicine White Paper
o LSI Public Talks featuring Personalized Medicine projects
q Achieve global compe::veness in commercializa:on ac:vi:es o Ten startups incorporated; 4 more under development
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The Life Sciences Institute
Vision for the LSI 2018: Best in Canada and Amongst Top Ten in World for Integrated Disease-‐Related Research
q Maintain and improve #1 ranking in Canada for basic life science research
q Achieve global compe::veness in transla:onal research to clinic o Raise $50M to pursue transla:onal research through personalized medicine
opportuni:es
q Achieve global compe::veness in commercializa:on ac:vi:es o At least 5 spinoffs and/or 5 technologies licensed out per year
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The Life Sciences Institute
Academic Committee
q Objec:ve: Maintain and improve #1 ranking in Canada for basic life science research
q First Mee:ng: Dec 15, 2014
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The Life Sciences Institute
The LSI Student and Trainee Support Fund
q Students and trainees are the common element to all LSI PIs
q New dona:ons fund to support LSI students and trainees
q Goal: $100,000
q Raised to date: $ 17,500
q Seeking further support internally and externally
q Ques:ons: • Leanne Denis (Medicine) • John Andru (Science)
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The Life Sciences Institute
Vision for the LSI 2018: Best in Canada and Amongst Top Ten in World for Integrated Disease-‐Related Research
q Maintain and improve #1 ranking in Canada for basic life science research
q Achieve global compe::veness in transla:onal research to clinic o Raise $50M to pursue transla:onal research through personalized medicine
opportuni:es
q Achieve global compe::veness in commercializa:on ac:vi:es o At least 5 spinoffs and/or 5 technologies licensed out per year
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The Life Sciences Institute
Human Omics Will Inform Basic Life Science Research
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Personalized Medicine Initiative
Database of Human Omics -‐genomics -‐proteomics
-‐metabolomics -‐microbiomics
-‐phenomics (clinical)
Empower & Inform Basic Sciences Research
Research @ LSI
Bacteriophage
Bacteria
Yeast
Worm
Fly
Zebrafish
Rodents
Understanding biology underlying disease
New diagnostics
New commercial opportunities
New therapeutics
Improved health Focused HQP training
Job Creation
The Life Sciences Institute
LSI/PMI Translational Projects
Large collabora+ve projects with a personalized medicine theme that have the objec+ve of changing clinical prac+ce
Budgets > $2M per project over 4 years
Translational Projects:
q Collaborate with clinician
q Perform Omics (genomics, proteomics, metabolomics, microbiomic) analysis
q Validate biomarkers for diagnosis and to guide treatment
q Iden:fy biology behind biomarker; iden:fy new therapeu:c targets
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The Life Sciences Institute
The PMI/ LSI has Thirteen Personalized Medicine Projects That Aim To Change Clinical Practice
1. Primary Care Pharmacogenomics 2. Cancer Pharmacogenomics 3. Au:sm Spectrum Disorders 4. Diabetes 5. Liver Fibrosis 6. Microbiomics 7. Cancer Immunotherapy 8. Brain Health 9. Cardiac Arrhythmias and Atrial Fibrilla:on 10. Ion Channel Molecular Structure Consor:um 11. Tuberculosis 12. Stroke 13. Sep:c Shock
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The Life Sciences Institute
The PMI/ LSI has Thirteen Personalized Medicine Projects That Aim To Change Clinical Practice
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Project LSI Lead Clinician Lead Objec+ve Budget
PGx in Family Prac:ce GenXys
Pieter Cullis Mar:n Dawes Use PGx to guide prescrip:on prac:ces $ 2.7M/
3yrs Cancer PGx Contextual Genomics
Pieter Cullis David Huntsman
Genetic tests to guide drug prescription for treatment of cancer
$ 2.1M/ 2yrs
iTARGET Au:sm Shernaz Bamji Suzanne Lewis
Early diagnos:c & individualized treatments for ASD
$ 12.3M/ 3yrs
Personalized Drugs for Diabetes Personalized Biomarkers Inc.
Tim Kieffer Tom Elliot
Iden:fy responders/ poten:al ADRs for GLP1 agonists
$ 3.2M/ 2yrs
Molecular Diagnos:cs for Liver Fibrosis FibroMDx
Francois Jean Mel Krajden
miRNA diagnos:c for stages of liver fibrosis
$ 4.3M/ 3yrs
Microbiome Insights Bill Mohn; Brett Finlay
Understand the role of the microbiome in health and disease
Cancer Immunotherapy Myeloid Enhancement Therapeutics
Ken Harder Development of immunotherapy for the treatment of cancer
The Life Sciences Institute
The PMI/ LSI has Thirteen Personalized Medicine Projects That Aim To Change Clinical Practice
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Project LSI Lead Clinician Lead Objec+ve Budget
Brain Health Synaptitude Max Cynader Early detection and treatment of
dementia
PGX of Cardiac Arrhythmias and Atrial Fibrilla:on
Ed Conway, Eric Accili, Filip Van Petegem Jason Andrade, Andrew Krahn, Shubhayan Sanatani
Early detection and prevention of cardiac arrest due to genetic defects; Genetic biomarkers to guide drug therapies
Ion Channel Molecular Structure Consor:um
Filip Van Petegem, Calvin Yip
Determine the molecular structure of ion channels for drug discovery and development
$15M/ 5 years
Tuberculosis Lindsay El+s, Charles Thompson James Johnson (BCCDC)
Tailored treatments for TB and mycobaterial infections
Stroke Preven:on Chris+an Naus Andrew Penn
Validate biomarkers to prevent stroke subsequent to a TIA
PGx and sep:c shock Bob Hancock James Russell
Test before treating with antibiotics and other therapies for septic shock
The Life Sciences Institute
How Are We Funding Large, Personalized Medicine Projects? Tac+cs: q Iden:fy projects aimed at changing clinical prac:ce
o Compelling unmet need o Major economic benefit o Appropriate exper:se available or accessible
q Develop Business Plan to raise funds o Iden:fy poten:al investors (gran:ng agencies, pharmaceu:cal companies,
philanthropy, government, healthcare, startups, venture) o Assemble demonstrably excellent team o Make scien:fic case and business/economic case
q Design investor presenta:ons oriented to selected audiences
q Engage poten:al investors
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The Life Sciences Institute
Example 1: PGx in Family Practice (P. Cullis & M. Dawes)
Budget: $ 2.7M / 3 yrs
q Objec:ve: Develop clinical decision support system (CDSS) to guide prescrip:on prac:ces for ~ 120 commonly prescribed drugs o 21 SNP panel ($40 test, $100 w/ blood draw) o 3yr 6,000 pa:ents over 65 on 10 or more drugs (20% of 65yr + popula:on) o Develop algorithms to use with EMR o Benefits: reduced drug use reduced ADRs and emergency visits
q Funding tac:cs o Business plan (complete) o Pitch to Rx&D Canada and Pharma, raise $760K from Rx&D; Pfizer, Merck, GSK,
Janssen, Roche, AstraZeneca; funds received) o Secure matching funds ($180K Genome BC received) o Form startup (GenXys), raise $ matching from investors, partners in process
Similar financing model: Cancer PGx to guide therapy ($750K commiOed from Pharma)
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The Life Sciences Institute
Example 2: iTARGET Autism (S. Bamji & S. Lewis)
Budget $ 12.3M / 3 yrs
q Objec:ve: Develop diagnos:c for early detec:on and stra:fica:on of au:sm spectrum disorder o WGS of 1500 pa:ents with ASD with complete medical history o Complementary proteomic, metabolomic and microbiomic analyses o Establish data repository and analysis capabili:es o Product: Omic-‐based CDSS to diagnose and stra:fy ASD at birth o Benefits: Early diagnosis > effec:ve interven:on with behavioural therapy
q Funding tac:cs o Business Plan (complete) o Partner with: Genome BC ($1M in process); Pacific Au:sm Family Centre (PAFC)
to raise $4M (in process); commercial partner to store data (in process, $200K in kind support commiOed); UBC to raise $10M from philanthropic sources (in process); when complete approach BC Government for final $2M.
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The Life Sciences Institute
Preventive Medicine Project; Provide Standard Analyses for Healthy Participants
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Rob Fraser
The Life Sciences Institute
Preventive Medicine Project; Provide Standard Analyses for Healthy Participants
q Improve and maintain health through early detec:on of disease using integrated Omics datasets o Individualized, molecular level informa:on for preven:ve health and
personalized medicine applica:ons o detect disease before it is serious o select the right treatment at the right :me
q Establish database of longitudinal par:cipant molecular data o Integrate with Ministry of Health Data o New IP poten:al
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The Life Sciences Institute
genome: Whole genome sequence and analysis proteome: 192 blood proteins from blood spot metabolome: 100 lipid an small molecule metabolites from blood draw microbiome: 1000’s of gut microbes from stool sample phenome: Ac:vity and behavior monitoring and modifica:on
Personalized User Manual For Your Body
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The Life Sciences Institute
How Does it Work?
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Present Practice
Molecular You
The Life Sciences Institute
Integrated Human Omics Approach Provides Direction for Basic Life Sciences Research
Proven Approach
Basic Life Science Research
Expe
r&se fo
und @ LSI
Bacteriophage
Bacteria
Yeast
Worm
Fly
Zebrafish
Rodents
NHP
Human
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Omics Approach
Human
Omics
Well People (Preven:ve Medicine)
Ill People (Disease cohorts)
The Life Sciences Institute
How Are We Funding Molecular You Co ?
q Objec:ve: Detec:on of biomarkers associated with early onset of disease o Enroll 1000 by 2017, expand to 10,000 total by 2020 o Par:cipants: Ini:al WGS and every 3 months perform proteomic, metabolomic
and microbiomic analyses, meet with healthcare professional for interpreta:on o Incidental findings may benefit par:cipants; access to data will benefit LSI/UBC
researchers o Establish “well oiled machine” to study disease cohorts in partnership with
healthcare system
q Funding tac:cs o Establish NewCo (Molecular You Corpora:on; MYCO) to enroll par:cipants at
cost ($10K 1st year, ~5K subsequent years) (Business Plan wriOen) o Pitch to poten:al investors to raise $6M to finance MYCO in tranches $1M 2014
($250K commiOed); $2M 2015 and $3M 2016
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The Life Sciences Institute
Vision for the LSI 2018: Best in Canada and Amongst Top Ten in World for Integrated Disease-‐Related Research
q Maintain and improve #1 ranking in Canada for basic life science research
q Achieve global compe::veness in transla:onal research to clinic o Raise $50M to pursue transla:onal research through personalized medicine
opportuni:es
q Achieve global compe::veness in commercializa:on ac:vi:es o At least 5 spinoffs and/or 5 technologies licensed out per year
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The Life Sciences Institute
The PMI Has Initiated Ten Start-‐Ups With More in Development
NewCos incorporated since 2010
1. Precision NanoSystems 2. Acuitas 3. MesenTech 4. GenXys Health Care Systems 5. Contextual Genomics 6. MetaMixis 7. PMI Personalized Medicine Ini:a:ve 8. Microbiome Insights 9. Personalized Biomarkers Inc 10. Myeloid Enhancement Therapeu:cs
NewCos in Development: Molecular You Corp., Exomics RDx, FibroMDx, Synap:tude, Service Outreach, LSI Protocols
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The Life Sciences Institute
Personalized Medicine Summit and White Paper June 7-‐9, 2015
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hOp://www.personalizedmedsummit.com/
Deliverable: White Paper to guide the implementa:on of molecular based medicine into the front lines of healthcare in BC and Canada
The Life Sciences Institute
New LSI Website Launched (www.lsi.ubc.ca)
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Neera Vohra
The Life Sciences Institute
New LSI Website Launched (www.lsi.ubc.ca)
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In line with the 3 main objective of LSI: • Maintain and improve #1 ranking in Canada for basic life science research
• Achieve global competitiveness in translational research to clinic • Achieve global competitiveness in commercialization activities
Targeted at key stakeholders – general public, government and research community with the objective of communicating how the various efforts being made at the LSI are impacting our community, economy and government decision making.
The Life Sciences Institute
News & Events
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The Life Sciences Institute
Personalized Medicine Projects
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The Life Sciences Institute
Commercialization
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The Life Sciences Institute
Students and Post Docs
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The Life Sciences Institute
LSI Website – Next Steps
q Con:nue making it relevant, regular updates to keep it current.
q A dymanic sec:on called ‘A scien:st’s life’ – a page from the researchers for the researchers
q Integrate Social Media
q What do you want to see?
q Comments at [email protected]
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The Life Sciences Institute
LSI Outreach and Omics Portal
Stefanie Butland
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The Life Sciences Institute
LSI Public Talks
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Oct 8, 2014 – Au:sm Nov 26, 2014 – Diabetes Feb 4, 2015 – Molecular You Mar 25, 2015 – World TB Day
The Life Sciences Institute
LSI Public Talks on Diabetes – Wed Nov 26, 6 PM
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hOp://lsi.ubc.ca/talks
The Life Sciences Institute
LSI Events
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q Nobel Laureate Venki Ramakrishnan – Sept 19
q Geek Olympiad (LSI GSA) – Oct 10
q Introduc:on to Intellectual Property – Nov 4
Upcoming Events
q Nov 26 -‐ LSI Public Talks – Diabetes
q Dec 11 -‐ FEI Cryo-‐TEM Workflow Solu:ons: A new era for 3D Structural Biology
q Dec 5 – LSI Holiday Party
The Life Sciences Institute
Omics Portal Launched
48 lis:ngs: services, training and online resources
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The Life Sciences Institute
Where is it?
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The Life Sciences Institute
What gets included?
Anything to enable research involving integrated Omics approaches o Academic & commercial o Local & remote o Core facili:es, services, online resources, training and networking
opportuni:es
Name of resource, some tagged with o URL o Descrip:on o Contact o LSI Collaborators and Users/Recommended by
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The Life Sciences Institute
Ctrl-‐f “metabolomics”
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The Life Sciences Institute
Matchmaking – LSI + CS / Math / Stats / Physics
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WEDNESDAY, DECEMBER 3, 12 PM FACULTY LOUNGE
The Life Sciences Institute
LSI Academic
Kevin Lin
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The Life Sciences Institute
Academic Committee
q Objec:ve: Maintain and improve #1 ranking in Canada for basic life science research
q Members o Shernaz Bamji o Julian Davies o Steven Hallam o Tim Kieffer o Jay Kizhakkedathu o Don Moerman o Robert Nabi o Chris Overall o Natalie Strynadka o Catherine van Raamsdonk
q First Mee:ng: Dec 15, 2014
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The Life Sciences Institute
LSI Strategic Grants Update
q Awai+ng results for these grants submiOed in 2014:
o CFI Innova:ons Fund (Playorm for Integrated Omics and Phenotyping) § $16M in equipment § $1.67M for opera:ons (over 5 years)
o NSERC CREATE Applica:on (Ecosystem Services, Commercializa:on Playorms and Entrepreneurship)
§ $1.65M (over 6 years)
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The Life Sciences Institute
LSI Strategic Grants Update
q Projects for 2015 submission:
o Canada First Research Excellence Fund § Nanomedicines Theme § Approved by VPRI for UBC LOI stage (15/107 were selected) § $50M available in inaugural year of award § UBC likely submit 1 applica:on
o NCE Centre for Commercializa:on and Research (CECR) § Personalized Medicine Ini:a:ve (PMI) § Nanomedicines & Drug Delivery Centre § $15M/centre for 5 years (1:1 matching required) § March 2015 LOI deadline
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PARTY! FRIDAY, DEC 5, 4-‐7 PM FOOD, CASH BAR, TREE-‐TRIMMING, ROCK & ROLL!