the land of chronic lyme
DESCRIPTION
The land of chronic Lyme. Everything works sometimes Eric Gordon MD [email protected]. Does chronic Lyme exist. Multiple animal models demonstrating borrelia despite previous antibiotic therapy - PowerPoint PPT PresentationTRANSCRIPT
![Page 2: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/2.jpg)
Does chronic Lyme exist• Multiple animal models demonstrating borrelia despite
previous antibiotic therapy• We see persistent IgM antibodies with and without IgG
antibodies in patients with symptoms that revert to negative IgM status with antibiotic treatment and symptom resolution
• Multiple studies demonstrating borrelia persistence in humans despite antibiotic therapy
• Our experience of positive Lyme cultures after prolonged antibiotic therapy
![Page 3: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/3.jpg)
Then why does IDSA insist that it doesn’t
• Lyme culture was not commercially available and it is an extremely fastidious organism
• Patients have multiple complaints that provoke the “psychological reflex” in physicians
• Other than a tendency to low wbc counts patients have normal labs ordered by most doctors including sed rate and Crp
![Page 4: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/4.jpg)
Then why does IDSA insist that it doesn’t
• Several studies showing no “significant “ improvement with repeated 1-2 month courses of antibiotics
• Fallon study showing minimal improvement with 6 months of rocephin (ceftriaxone)
• Stridency of patients with unexplained chronic complex symptoms and normal tests and “normal” PE who are referred to Infectious disease specialists by doctors and family
![Page 5: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/5.jpg)
Problem of standard Western Blot testing
• Chronic patients often have negative IgG Western Blots (WB) and “false “ positive IgM WB
• Labcorp and Quest WB’s have low sensitivity and are especially poor outside of new England
• We don' t know the number of people who have Lyme who have a failure to develop antibodies
![Page 6: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/6.jpg)
Problem of standard Western Blot testing
• WB testing bands Decided at conference held by CDC in Dearborn , Michigan in 1994. The IgG criteria were based on a paper from 1993 by Dressler, Whalen, Reinhardt and Steere . They looked at WB's from several dozen well characterized Lyme patients with strong immune responses and found that by requiring 5 out of 10 IgG bands the WB could be highly specific but did lose some sensitivity
![Page 7: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/7.jpg)
Problem of standard Western Blot testing
• IgM criteria were developed from other similar papers only 2 of 3 IgM bands are necessary . The first IgM bands that show up are 41, 22-25 , and 39.41 is to the flagellar protein and is not specific to LymeThe CDC has decided that since IgM is an acute event you should ignore it starting 6 weeks after infection
![Page 8: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/8.jpg)
Problem of standard Western Blot testing
• Early sub-therapeutic treatment can interfere with the immune response leading to negative antibody tests
• Many people who relapse after antibiotic treatment are sero-negative till after retreatment
• Some people with culture positive Lyme disease are sero negative by WB even though they were positive when first diagnosed years earlier
• Sometimes they are sero-negative because all the antibody is tied up in immune complexes
![Page 9: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/9.jpg)
Lyme specific bands according to ILADS and our clinical judgment
• 31= OspA 22-25 = OspC 34= OspB 18, 39, 83-94CDC criteria leave out 31 and 34 even though they are specific for Lyme disease because they tend to show up later in the disease and this wasn't the population Dressler et al studied.31 is OspA which is the antigen used in the early Lyme vaccines ( Osp=Outer surface protein)
![Page 10: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/10.jpg)
Everybody is right but nobody trusts each other
• Chronic Lyme exists and sometimes antibiotics help • People develop autoimmune diseases and
sometimes removing the trigger helps(Lyme )• IDSA studies only include patients who fit CDC
criteria-circular reasoning• Sometimes antibiotics don’t help and make people
worse• Unneeded antibiotics cause severe dysbiosis• PICC line infections do happen
![Page 11: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/11.jpg)
Testing limitations and controversies Advanced laboratory Systems (ALS)
• Need to be off all treatment for 4 weeks and best to draw in afternoon when symptomatic
• Initial darkfield exam then 10-14 day culture and repeat darkfield if negative another 8 week and if needed another 8 weeks of culture
• If positive darkfield then borrelia specific staining and if desired PCR for species
• 100% negatives on controls• 7% false negatives in patients• B Garini found in high % of cultures done in Sapi lab leading to
claims of contamination. This is not same location as ALS lab.
![Page 12: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/12.jpg)
Testing limitations and controversies iSpot
• Melisa test evaluating T cell reactivity measuring Interferon gamma production after exposure to Lyme antigens
• Main problem is lots of false negatives but at least they identify them
• Because in chronic patients there is high percentage of poor T cell Interferon gamma production after stimulation by phytohemagglutinin as a screening test
• Pharmasan.com
![Page 13: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/13.jpg)
Testing limitations and controversiesprovoked urine testing
• IDSA –unproven• Requires oral or IM antibiotic provocation• Measures Lyme antigen in urine • Igenex .com
![Page 14: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/14.jpg)
Testing limitations and controversiesDNA PCR testing
• IDSA –unproven• DNA may remain but non-viable and non-
infectious• Milford Medical lab Borrelia burgdorferi, and
Borrelia miyamotoi • Igenex lab
![Page 15: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/15.jpg)
Complicating issues• Mold and other neurotoxins• Co-infections• Biochemical individuality (genetics and epigenetics)• Dysbiosis• Heavy metals• EMF• Psyche• Structural• Dental• Biofilms
![Page 16: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/16.jpg)
Mold
Always suspect when you think babesia and especially when pain and brain fog are out of proportion and especially when intermittent
• Realtime lab mycotoxin panel $700 initial followup $200
• Best to collect urine in the AM after sauna or several days of Glutathione
• Dr Brewer uses CSM but also charcoal and bentonite for tricothecene and aflatoxin Toxins 2014, 6, 66-80; doi:10.3390/toxins6010066
![Page 17: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/17.jpg)
Mold
• Dr Shoemaker –Visual Contrast Study for neurotoxicity, markers of innate immunity C4a, VIP ,MSH, VEGF. TGF-beta-1, CD4CD25++,
• Remove from exposure and use binders then nasal VIP when other markers are corrected
• He prefers Cholestyramine (CSM)• Please see Dr Shoemakers website
Survivingmold.com
![Page 18: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/18.jpg)
Neurotoxins
• Mold, Babesia, Lyme• Lipophyllic-use intestinal binders• Cholestyramine, welchol, chitosan, charcoal,
bentonite, zeolite• Start slow – moving toxins can cause
symptoms• Remove from exposure
![Page 19: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/19.jpg)
Co-infections
• Bartonella, Babesia, Ehrlichia• Protomyxoma rheumatica ?• Mycoplasma pneumonia• Chlamydia Pneumonia• Rickettsia’s• Tularemia, Q fever (Coxiella Burnetii)• Parasites• Viruses-EBV, HHV6,CMV, Coxsackie
![Page 20: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/20.jpg)
Parasites
• If any clinical hint, treat parasites first, and repeatedly, if any clinical response.
• Multiple herbal treatments• Biltricide for flukes, tapeworms• Ivermectin for microfilaria • Pyrantel pamoate for hookworms and roundworms • Albendazole- roundworms, tapeworms and flukes• Alinia- for everything -caution
![Page 21: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/21.jpg)
Biochemical individualityepigenetics and genetics
• Methylation cycle- MTHFR Ben Lynch et al, Glutathione –Von Konynberg ,Nathan –order phenotype testing from Vitamindiagnostics.com
• HLA-DR per Ritchie Shoemaker 04-3-53 and 11-5-51 etc some correlation with sicker patients- defects in antibody presentation or toxin problems
![Page 22: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/22.jpg)
Biochemical individualityepigenetics and genetics
• Celiac and gluten sensitivity• Porphyria- spot urine when symptomatic• Kryptopyrroluria• Mast cell activation• Cytochrome p450 variations• Oxalate –Susan Owens lowoxalates.com
![Page 23: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/23.jpg)
Heavy Metals
• Mercury , Lead, Arsenic, Cadmium• Aluminum• Hair analysis• Quicksilver –hair, serum, and urine• DMPS, CaEDTA challenge test- make sure
glutathione is adequate and patient not too toxic
• DMSA
![Page 24: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/24.jpg)
EMF
• Check house and work• Remove toxins and strengthen membrane
integrity• Decrease inflammation• Richard Conrad—ConradBiologic.com• Stetzerelectric.com
![Page 25: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/25.jpg)
Psyche
• Not psychological• Bugs effect nervous system• Amplification of your normal neurotic qualities• Sensitization to all input• Loss of social support• Therapy that the patient can receive - have
different modalities• Annie Hopper , Ashok Gupta, others
![Page 26: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/26.jpg)
Structural issues and Detox
• Inflammation + structural dysfunction = pain and a good place for bugs and toxins to accumulate
• Need osteopath, chiropractor, physical therapist, massage therapist
• Acupuncture, FSM (frequency specific microcurrent) Scenar, laser, ,photon stim etc.
• Sauna, colonics, baths• Rectal ozone • Diet, diet, nutrition, diet, trace minerals ,diet
![Page 27: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/27.jpg)
Dental
• Chronic infections-wisdom teeth sites, root canals
• Need ICAT –plain films will miss infection• TMJ• Mercury• Galvanic testing when metal is present
![Page 28: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/28.jpg)
Biofilms
• planktonic forms are where we look for the bugs but it but they live in biofilms
• Complex structures-hi in Ca,Mg, Fe• Don’t try to destroy them too early• EDTA, Enzymes, Silver• Costerton, J. W youtube.com/watch?
v=M_DWNFFgHbE
![Page 29: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/29.jpg)
Bottom line
• Listen and look closely at your patient• If robust and recent onset of symptoms feel
free to use antibiotics but consider herbal treatments first if you feel infection has been there for more than 6-12 months. Less antibiotics the better.
• Sensitive and sick for a long time- start slow and don’t think you can’t mess them up with energetic or herbal therapies
![Page 30: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/30.jpg)
Treatment
• Always use probiotics and saccharomyces boulardi
• Join ILADS and read Burrascano and Horowitz• Do an ILADS preceptorship• Start slow and believe your patients
![Page 31: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/31.jpg)
TreatmentsAntibiotics
• Oral –Hi dose Doxycycline and rifampin with macrolides and hydrochloroquine
• Omnicef 300mg two bid with macrolides• Bactrim DS bid with rifampin 300mg bid +/- macrolides or
just rifampin 300mg bid +/- macrolides• Macrolides-Zithromax 250-600mg and Biaxin 1000mg qd
usually with hydrochloroquine • All of these can and should be modified to patient tolerance
especially rifampin (cytP450 issues) Use Biaxin instead of Zithromax with rifampin
• Metronidizole, Tindamax (cyst busters)
![Page 32: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/32.jpg)
TreatmentIV antibiotics 3days out of 7
Standard therapy Rocephin 2 gm bid remember to add Actigal 300mg bid
My preference is Claforan 4 gm tidMany other options best to discuss with experienced cliniciansOccasionally if no response to cephalosporins Vancomycin 1 gm
q12 hours with trough levels between 10-20 is effective (Bartonella)
I almost always add Argentyn 23, 30cc per day for its synergistic effect
Pulse therapy and consider Doxy , macrolides , Rifampin, Tinidizole, and be extra cautious with quinolones
![Page 33: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/33.jpg)
Other IV therapies
• Ozone Dr David Minkoff and also hi pressure ozone per Dr Robert Rowan and Dr Woitzel , Zotzmann in Germany makes a machine
• H2O2 2.5-5cc of 3% with 10cc DMSO in 250-500cc D5W with Mn and MgCl to protect veins per Dr Brodie
• UVB treatments• IV homeopathics to help detox• IV silver to augment antibiotics• IV Phosphatidylcholine ,phenylbutyrate and glutathione
for detox
![Page 34: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/34.jpg)
TreatmentBasic Herbal list
• Nutramedix---Samento, Banderol, Cumanda, Enula
• Classical Pearls- Lightening and Thunder pearls• Dr Zhang- HH• Byron White –A-L, A-Bart , A-Bab, A-Myco• Beyond balance BB-1, Bab-1&2, Bart-1• Dr Buhner- Japanese knotwood, cats claw, sida
acuta, cryptolepsis
![Page 35: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/35.jpg)
Immune Support
• GcMAF -measure Nagalase at health diagnostics- oral and injectable forms
• Vit D – check 25 and 1-25 Vit D• LDN –low dose naltrexone • Herbs
![Page 36: The land of chronic Lyme](https://reader036.vdocuments.us/reader036/viewer/2022062501/5681677a550346895ddc7ae2/html5/thumbnails/36.jpg)
Energetic treatments
• Multiple Vega and subsequent devices for diagnosis and treatment
• Frequency generating machines such as Doug coil, pulsedtechnologies.com, many others
• Biophoton therapies –Dr Woitzel in Germany and Johan Boswinkel in Netherlands