the koyal group info mag: how a failed experiment on rats sparked a billion-dollar infant-care...

8/10/2019 The Koyal Group Info Mag: How A Failed Experiment On Rats Sparked A Billion-Dollar Infant-Care Breakthrough

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The Koyal Group Info Mag: How A Failed Experiment On Rats Sparked

A Billion-Dollar Infant-Care Breakthrough

WASHINGTON -- At a research lab at Duke University Department of Pharmacology in 1979, a

group of scientists sparked a major breakthrough in infant care from a failed experiment on

rats.

At the time, Dr. Saul Schanberg, a neuroscientist and physician, was running tests on just-born

rats to measure growth-related markers (enzymes and hormones) in their brains. Together with

Dr. Cynthia Kuhn and lab technician Gary Evoniuk, he kept getting weird results. With the rat

pups separated from their mothers in order to run the experiments, their growth markers kept

registering at low levels.

The team varied the trials. They used an anesthetized mother rat to feed the pups during and

after the experimentation, and tried keeping the pups and mother in the same cage but with a

divider to see if a lack of pheromones was the problem.

The experiment failed, Kuhn recalled.

So the team approached it from another angle. Instead of stabilizing the rat pups so they couldrun tests, they tried to figure out what was wrong with the pups in the first place. From a

friend, Kuhn had heard theories that massaging the pups could produce positive results.

Evoniuk, meanwhile, had watched mother rats groom their pups by vigorously licking them. He

proposed doing essentially the same thing, minus the tongue.
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The team began using a wet brush to rub the rat pups at different pressure levels. Eventually,

they found the right one, and on cue, the deprivation effect was reversed.

"I said, 'Lets give it a shot,' and it worked the first time and the second time," recalled Ev oniuk.

"It was just the touch.

Though they had no way of knowing it, Schanbergs team had taken the first step in a process

that would see the upending of conventional wisdom when it came to post-natal care. Three

and a half decades later, the theories that his team stumbled upon by failure would save an

estimated billions of dollars in medical costs and affect countless young parents lives.

On Thursday night, the team will be rewarded for its work. A coalition of business, university

and scientific organizations will present the Golden Goose Award to them and other

researchers with similar successful projects. It is a prize given for the purpose of shining a light

on how research with odd-sounding origins (really, massaging rat pups?) can produce

groundbreaking results. More broadly, its meant to showcase the importance of federa lly

funded scientific research.

The work done by Schanbergs team is inextricably tied to the support of taxpayers -- not just

because the group operated from a grant of approximately $273,000 from the National

Institutes of Health. As Kuhn and Evoniuk both argued, the breakthrough they were able to

produce never could have happened with a private funding source. The demand for an

immediate result or for profit wouldnt have allowed them topivot off the initial failure.

It is not a straight path from point A to point B, said Evoniuk. There are all kinds of weird

little detours. We were really following a detour from where this work started. The federal

funding gave people like Saul the ability to follow their scientific instincts and try to find the

answers to interesting questions that popped up.

As Congress members head back to their districts before the midterm elections, fights over

science funding appear to be low on the list of priorities. The two parties are in the midst of an

informal truce, having put in place budget caps this past winter. And no one seems particularly

eager to disrupt that truce, even if science advocates warn it needs upending.

While NIH's funding increased this year from last year, when sequestration forced an estimated

$1.55 billion reduction, it still fell $714 million short of pre-sequestration levels. Adjusted for

inflation, it was lower than every year but President George W. Bush's first year in office.

Surveying the climate, the American Academy for Arts & Science released a report this week

showing that the United States "has slipped to tenth place" among economically advanced

nations in overall research and development investment as a percentage of GDP. For science
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advocates, it was another sobering cause for alarm. Young researchers, they argue, are leaving

the field or country. Projects that could yield tremendous biomedical breakthroughs aren't

getting off the ground.

Looming over the Golden Goose awards ceremony is this reality: Would an experiment testing

rat-pup massages ever survive this political climate? Would it be admonished as waste by

deficit hawks in Congress?

Researchers massaging rats sounds strange, but oddball science saves lives, said Rep. Jim

Cooper (D-Tenn.), who is participating in the awards ceremony. In this instance, premature

babies got a healthier start. If Congress abandons research funding, we could miss the next

unexpected breakthrough.

NIH funding was certainly critical to the successful research behind rat-pup massages. "Without

the NIH none of this would have happened, zero," said Kuhn.

But serendipity also played a role. Not long after he made his discovery, Schanberg was at an

NIH study section with Tiffany Field, a psychologist at the University of Miami School of

Medicine. Field had also been doing research -- also funded by the NIH -- on massage therapies

for prematurely born babies. But she was getting poor results.

"We were just sharing our data, basically," Field recalled of that conversation. "I was telling him

we were having trouble getting any positive effects with the preemies. He talked about how

his lab technician had an eureka experiment when he saw his mother's tongue licking the

babies."

The conclusion reached was that Field probably wasn't massaging the premature babies hard

enough. Instead of applying "moderate pressure" (as Schanberg had been doing) she was

applying more of a "soft stroking."

A study done on rats became a study on humans. Field changed up her experiment and began

to see results right away. Instead of the discomfort felt from that tickle-like sensation, the

moderate pressure had a tonic effect, stimulating receptors. Babies' heart rates slowed down;

the preemies seemed more relaxed; they were able to absorb food and gain weight; there was

more evidence of growth hormone; an increase in insulin; greater bone density; and greater

movement of the GI tract. The magnitude of the finding was enormous.

"We published the data and we actually did a cost-benefit analysis at that point and

determined we could save $4.8 billion per year by massaging all the preemies, because of all

the significant cost savings for the hospital," Field recalled.
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Her conclusion challenged the prevailing sentiment of the time that prematurely born babies

should be left in incubators, fed intravenously, and not touched immediately after birth lest

they become agitated and potentially harmed. But few people listened.

"The only person who paid attention to it was Hillary Clinton," she recalled, noting that Clinton,

who was working on a health care reform initiative as First Lady, expressed interest in the

research.

Since then, however, conceptions of post-natal care have changed. Subsequent studies have

confirmed Field's findings, though others have questioned whether there is enough research or

the proper methodology to draw sweeping conclusions. Nevertheless, whereas few people

used massage therapies in the '80s and '90s, as of eight years ago 38 percent of natal care units

were using those therapies, said Fields. The method is estimated to save $10,000 per infant --

roughly $4.7 billion a year.

Those involved in the research still marvel that the chain of events started with a failed

experiment on rats and turned on a fortuitous meeting between two scientists.

"We didnt set out to figure out how to improve nursing care," said Kuhn. "But we wound up

saving a lot of money and helped babies grow better, their cognitive outcome was better, they

got out of the [intensive care units] sooner. There was no downside."

"One thing led to another," said Evoniuk. "We were just kind of following an interesting

question not thinking we were going to change medical practice."

Schanberg won't be around to receive his Golden Goose award Thursday night. He died in 2009,and his granddaughter will accept on his behalf. But those who worked with him say that his

research remains a testament to the good results that an inquisitive mind and a respectable

funding stream can produce. It's a story that scientists may find uplifting.

But it doesn't necessarily have a happy ending.

In the aftermath of her work with Schanberg, Field continued studying natal care, starting the

Touch Research Institute at the University of Miami in 1992 with the help from the NIH and

Johnson & Johnson. Her work has been widely cited in medical journals and newspaper articles.

But the funding streams have run dry, and now she's faced with the prospect of dramatically

narrowing the scope of her lifelong work.


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