the key to every biological problem must finally be sought in the cell, for every
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The key to every biological problem must finally be sought in the cell, for every living organism is, or at some time has been, a cell. E. B. Wilson, 1925. Distribuição dos grânulos P = divisão assimétrica E geração da linhagem germinativa. Susan Strome, 19. 5 m m. 1 m m. - PowerPoint PPT PresentationTRANSCRIPT
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The key to every biological problem mustfinally be sought in the cell, for everyliving organism is, or at some time hasbeen, a cell.
E. B. Wilson, 1925
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Distribuição dos grânulos P = divisão assimétricaE geração da linhagem germinativa
Susan Strome, 19
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Corte óptico tangencial
5 m
Corte óptico transversal
1 m
Grânulos P nos ovócitos “sinciciais”
1 m
Pitt e cols., Devel. Biol. 219, 315-333, 2000
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Entrada do espermatozóideFim da meioseCorrentes citoplasmáticasInteração corticalMigraçãoPseudoclivagemCentralizaçãoRotaçãoMetáfaseDeslocamento do fusoCitocinese
Anterior Posterior
Divisão assimétrica
Primeira clivagem em 12 passos
Schneider & Browerman, Annu. Rev. 37, 221-249, 2003
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G nczy, Trends Cell Biol. 12, 332-339, 2002
Mitose simétrica e assimétrica
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Posicionamento do fuso
G nczy, Trends Cell Biol. 12, 332-339, 2002
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Eventos temporais na ovogênese, meiose e primeira divisão mitótica
Schneider & Browerman, Annu. Rev. 37, 221-249, 2003
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ANTERIOR POSTERIOR
PAR-3PAR-6
PKC-3
Proteínas quinase C atípica
Proteínas com domínio PDZ
PAR-1
PAR-2
Ser-Thr quinase
Proteína “ring-finger”
PAR-4PAR-5
Uniformementedistribuídas
Proteínas envolvidas na polaridade do ovo
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Hierarquia das proteínas PAR em C. elegans
Pellettieri & Seydoux, Science 298, 1946-1950, 2002
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G nczy, Trends Cell Biol. 12, 332-339, 2002
centríolo
grânulo P
núcleo
PAR-2
âncoracortical
Acoplamento da mitose e redistribuição citoplasmática
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Orientação do fuso mitótico e localização de par-3
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MES-4 associa-se a autossomos mas não aos cromossomos X
anti-cromatina anti-MES-4 sobreposição
Fong e cols., Science 296, 2235-2238, 2002
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Modelo de como a distinção de soma e germe é estabelecida e mantida no germe
Shin & Mello, Curr. Opinion Genet Devel. 13, 455-462, 2003