the john curtin school medical research · 2018. 4. 13. · jcsmr 2006 from the director it is with...
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THE JOHN CURTIN SCHOOL OF MEDICAL RESEARCH
Annual Review 2006
Health Through Discovery
ANU COLLEGE OF MEDICINE & HEALTH SCIENCES
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Introduction
The John Curtin School of Medical Research (JCSMR) was established as a result of the vision of Australian Nobel Laureate Howard Florey and war-time Prime Minister John Curtin. JCSMR researchers continue to strive towards Florey’s vision – of a national medical research school undertaking superlative medical research in fundamental areas. Opened in 1948, the School boasts almost 60 years of prize winning research, including three Nobel Laureates in Physiology or Medicine, The Japan Prize, The Copley Medal, and The Albert Einstein World Award for Science.
The goals of The John Curtin School of Medical Research are to:
• play a leadership role in medical research in Australia
• conduct research of the highest international standard into fundamental life processes and the pathologies of these processes which cause human disease
• provide outstanding training in medical research for young scientists and health professionals
• apply new knowledge for better health outcomes.
The School has three major research divisions, Molecular Bioscience, Immunology and Genetics, and Neuroscience, each comprised of independent research groups and laboratories. The High Blood Pressure Research Unit is headed by the School’s Director. A unique feature and major strength of JCSMR is the diverse nature of the research programs, including genomics, immunity, gene regulation and cell signalling, neuroscience and integrative physiology. These areas benefit enormously from the potential for mutual interaction and collaboration across Divisions, enabling the School to make important contributions to the understanding of many diseases, including diabetes, cancer, asthma and high blood pressure, infectious disease, hearing, vision and memory.
We are committed to training medical researchers of the future, from Australia and overseas. Many of our postgraduate students are carrying out research directed towards a PhD degree and we share supervision of Honours students with the ANU Colleges and other institutions.
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Introduction to The John Curtin School of Medical Research
From the Director . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Highlights . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Outcomes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 JCSMR Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Boards and Committees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
Research Programs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Division of Immunology and Genetics . . . . . . . . . . . . . . . . . . . . . . 10 Division of Molecular Bioscience . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Division of Neuroscience . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 High Blood Pressure Research Unit . . . . . . . . . . . . . . . . . . . . . . . . 28
Staff & Student Achievements . . . . . . . . . . . . . . . . . . . . . . . . . 29
Research Collaborations & Visitors . . . . . . . . . . . . . . . . . . . . . . 33 Research Collaborations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Visitors to JCSMR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
Staff, Students & Invited Presentations . . . . . . . . . . . . . . . . . . 45 Division of Immunology and Genetics . . . . . . . . . . . . . . . . . . . . . . 46 Division of Molecular Bioscience . . . . . . . . . . . . . . . . . . . . . . . . . . 52 Division of Neuroscience . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 High Blood Pressure Research Unit . . . . . . . . . . . . . . . . . . . . . . . . 58 Students . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 School Administration and Services . . . . . . . . . . . . . . . . . . . . . . . 61
Publications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 Contact with our Community . . . . . . . . . . . . . . . . . . . . . . . . . . 75 Voluntary Service to Organisations outside JCSMR . . . . . . . . . . . 79
Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 Grants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 Statistics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 Donors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90
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JCSMR 2006
From the Director
It is with great pleasure that I present The John Curtin School of Medical Research Annual Review 2006 to provide an overview of the many and varied research and teaching activities carried out by our staff and students throughout the year, and to highlight our achievements.
2006 saw many changes to the structure of JCSMR, as Stage 1 of our new building reached completion. Staff began the move into the new laboratories in July, and both new and old buildings now house active research programs. The new building itself, designed by Lyons (Melbourne) has attracted an enormous amount of interest and has won Awards for project managers Hindmarsh – including the ACT Master Builders Association Project of the Year, and subsequently the MBA National Presidents Award. There were some nostalgic farewells as staff and students said goodbye to the Florey Lecture Theatre and the old Tea Room. There were also many celebrations. We were very pleased to welcome Drs Alan and Elizabeth Finkel to open The Finkel Lecture Theatre in October and members of the Australian Cancer Research Foundation were present as ACT MLA Katy Gallagher opened the new ACRF funded Biomolecular Resource Facility. Demolition work has commenced once more, and the Wing C footprint will make way for Stage 2 of the new building, due for completion early in 2009.
Research has continued throughout the construction process. Professor Lamb received the Proctor Medal for his vision research and Professor Goodnow was awarded an Australian Research Council Federation Fellowship. We were pleased to present Professor Sam Berkovic with the Curtin Medal for his research into the neurobiology of human epilepsies.
JCSMR researchers continued to enjoy success in attracting grants from national and overseas granting bodies. We are grateful to the friends and donors who support projects within the School, and to those who have chosen to endow Scholarships and Prizes recognising the high calibre of research performed by our staff and students.
Judith Whitworth AC
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Curtin Medal
• TheCurtinMedalwaspresentedtoProfessorSamuelBerkovic,HeadoftheComprehensiveEpilepsyProgramattheAustinHospitalandtheEpilepsyResearchCentreoftheUniversityofMelbourne.ProfessorBerkovicseekstounderstandthebasicneurobiologyofhumanepilepsies,usingvariedapproachestogaininsightsthatcanbeusedfordiagnosisandtreatmentofpatients.Thisresearchhaspioneeredunderstandingofthegeneticbasesforepilepsy.
Proctor Medal
• ProfessorTrevorLamb(DivisionofNeuroscience)andhiscolleagueProfessorEdPugh(UniversityofPennsylvania)wereawardedtheProctorMedaloftheAssociationforResearchinVisionandOphthalmology(ARVO).TheProctorMedalispresentedannuallyforoutstandingresearchinthebasicorclinicalsciencesasappliedtoophthalmology.
Federation Fellowship
• ProfessorChristopherGoodnow(DivisionofImmunologyandGenetics)wasawardedanARCFederationFellowship.ProfessorGoodnow,HeadoftheImmunogenomicsLaboratoryatTheJohnCurtinSchoolofMedicalResearchandDirectoroftheAustralianPhenomicsFacility,willbuildaninternationalImmunityandInfectionGenomicsConsortiumcentredinAustraliatotacklethreefundamentalquestionsaboutthemammalianimmunesystem:howdoesthesystemlearnnottoattackself-components,howdoesitenhancerecallresponsestovaccines,andwhydoesitfailtoeliminateformidableforeignmicrobes?
Graduation success
• Wecongratulatethe15PhDand14HonoursstudentswhosuccessfullycompletedtheirstudiesinTheJohnCurtinSchoolofMedicalResearchduring2006.
Highlights
Highlights & Outcomes 2006
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JCSMR 2006
Significant Outcomes
Stage 1 Complete
• Stage1ofthenewJCSMRBuildingwascompletedinJulyandaroundathirdofourstaffhavemovedintothenewlaboratories.Thebuilding,designedbyLyons(Melbourne)haswonanumberofawards.ProjectmanagersHindmarshwereawardedthe2006ACTMasterBuildersAssociationProjectoftheYear,andsubsequentlytheMBANationalPresident’sAward.DemolitionofWingCoftheoldbuildingwillmakewayforconstructionofStage2.Thissecondstagewillhouseresearchlaboratoriesandcontainmentfacilitiesaswellascoreschoolscientificsupportunits.
Liver cancer trials to begin
• Theanti-cancertherapeuticagentPI-88developedwithintheJCSMRlaboratoryofProfessorChrisParish(DivisionofImmunologyandGenetics)hasshownpromisingresultsinPhaseIItrials,andwillnowmoveintoPhaseIIItrialsasatreatmentforlivercancer.
National Centre for Biosecurity announced
• ANUViceChancellor,ProfessorIanChubbannouncedthecreationofanewNationalCentreforBiosecurity.LedbyJCSMRimmunologistProfessorIanRamshaw,theCentrebringstogethermicrobiologists,epidemiologists,lawyers,ethicists,securityanalysts,infectiousdiseasemodellers,policyexperts,andintegrationandimplementationscientists.TheCentrewilltakea‘realworld’approachtothecomplexproblemsofbiosecurityandprovideanessentiallinkbetweenthemanyrelevantdisciplines.
ANU College of Medicine and Health Sciences
• During2006,JCSMRjoinedtheANUCollegeofMedicineandHealthSciences.AnumberofJCSMRadministrativestafftransferredintothenewlyformedCollegeAdministrativeGroup(CAG)andcontinuetoprovidehighqualityadministrativesupport.
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JCSMR Structure 2006
During 2006, a number of JCSMR administrative staff members were transferred into the newly formed ANU College of Medicine and Health Sciences Administration Group (CAG).
Student Convenoruntil September 2006
Adm
inis
trat
ion
Human Resource Managementuntil July 2006
General Services
Financial and Research Support
until July 2006
Director’s Office
The Australian National University
The John Curtin School of Medical Research
Director
Neuroscience
Molecular Bioscience
Immunology and Genetics
Rese
arch
gro
ups,
unit
s an
d la
bora
torie
s
High Blood Pressure
Research Unit
Technical Services
Microscopy and Cytometry Facility
BiomolecularResource Facility
Animal Services
Information Technology and Communications Unit
until July 2006
Media and Washup
Serv
ices
and
Sup
port
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JCSMR 2006
Boards & Committees 2006
Faculty Board 2006
The Director (Chair), ex officioProfessorJAWhitworth
The Deputy Director, ex officioProfessorSJRedman
Chair of Faculty, ex officioProfessorIARamshaw
The Convenor, Graduate Program in Medical Sciences, ex officioDrAICowan(fromFebruary)
Head, Division of Immunology and Genetics, ex officioProfessorCRParish
Head, Division of Molecular Bioscience, ex officioProfessorMFShannon
Head, Division of Neuroscience, ex officioDrGStuart
Divisional RepresentativesDrABlackburn(MolecularBioscience)(untilFebruary)DrGKarupiah(ImmunologyandGenetics)DrCRaymond(Neuroscience)DrAShield(MolecularBioscience)(fromMarch)
Graduate Student RepresentativesMrKBrown(untilMay)MsLCoupland(fromJune)MrIPoon(fromJune)
General Staff RepresentativesMsMTownsendMrBWebb,BusinessManager
By InvitationDrMJNicol,PublicAffairsManager
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Strategic Advisory Committee
The JCSMR Research Advisory Board provides advice to the Director regarding the advancement of the research programs currently undertaken within the School and on proposals for future projects.
Director,JCSMR(Chair),ex officio
DeputyDirector,JCSMR,ex officio
SirDavidAkers-Jones,HongKong
ProfessorPeterDohertyAC,TheUniversityofMelbourne,Melbourne,VIC
MrAlanEvans,StrategicConsultingServices,Canberra,ACT
MrPeterGordon,Canberra,ACT
MsPruGoward,FederalSexDiscriminationCommissioner,Canberra,ACT
ProfessorColinJohnstonAO,BakerMedicalResearchInstitute,Melbourne,VIC
TheHonDrBarryJonesAO,Melbourne,VIC
DrDenisWKing,StGeorgePrivateMedicalHospital,Sydney,NSW
AssociateProfessorLevonKhachigian,CentreforVascularResearch,TheUniversityofNewSouthWales,Sydney,NSW(ASMRPresident)
MrAndrewPodgerAO,Canberra,ACT
DrJohnRoseAO,DirectorAustralianUnitedInvestmentCompany;Governor,IanPotterFoundation,Melbourne,VIC
MrDavidVos,InspectorGeneralofTaxation,Sydney,NSW
DrCameronWebber,Canberra,ACT
MrRobertWells,ExecutiveDirector,ANUCollegeofMedicineandHealthSciences,Canberra,ACT
Research Advisory Board
The JCSMR Strategic Advisory Committee convenes annually to advise the Director on ways of achieving the School’s strategic direction, including administration and management of the School, and raising the profile of JCSMR nationally and internationally. Members also provide assistance with fundraising activities and advise on commercialisation of research.
Director,JCSMR(Chair),ex officio
DeputyDirector,JCSMR,ex officio
DeputyVice-Chancellor(Research),ANU,ex officio
Chair,JCSMRFaculty,ex officio
ProfessorJerryAdams,TheWalterandElizaHallInstitute,Melbourne,VIC
ProfessorRobBaxter,KollingInstituteofMedicalResearch,Sydney,NSW(NHMRCnominee)
ProfessorSamBerkovic,AustinandRepatriationMedicalCentre,Melbourne,VIC
ProfessorRossCoppel,MonashUniversity,Melbourne,VIC
ProfessorTonyD’Apice,DepartmentofClinicalImmunology,StVincent’sHospital,Melbourne,VIC
ProfessorAnneKelso,QueenslandInstituteofMedicalResearch,Brisbane,QLD
ProfessorKiaranKirk,FacultyofScience,ANUCollegeofScience,Canberra,ACT
DrGeorgeMorstyn,TheUniversityofMelbourne,Melbourne,VIC
ProfessorJonathonStone,ResearchSchoolofBiologicalSciences,ANUCollegeofScience,Canberra,ACT
ProfessorBrandonWainwright,UniversityofQueensland,Brisbane,QLD
TheJohnCurtinSchoolofMedicalResearchisorganised
intothreeDivisions:ImmunologyandGenetics,Molecular
Bioscience,andNeuroscience.TheHighBloodPressure
ResearchUnitisheadedbytheDirector.
WithintheDivisions,staffandstudentsbelongtoGroups
orLaboratories.Membersofthesegroupscollaborateacross
DivisionswithintheSchoolandacrossTheAustralianNational
University,aswellaswithcolleaguesinotherinstitutions.The
followingpagesprovideanoverviewoftheresearchprojects
beingundertakenwithintheSchool.
Research Programs
The John Curtin School of Medical Research Annual Review 2006
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Head of Division Professor Christopher Parish
Cancer and Human Immunology Group
Cancer and Vascular Biology Group
Diabetes/Transplation Immunobiology Group
Immunogenomics Laboratory
• Immune Tolerance and Signalling Group
• Humoral Immunity and Autoimmunity Group
• T- Cell Development and Regulation Group
Immunopathology Group
Infection and Immunity Group
Vaccine Immunology Group
Viral Immunology Group
Molecular Virology Group
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Groups & Laboratories
Division of Immunology & Genetics
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Division of Immunology and Genetics
Division of Immunology & GeneticsImmunogenomics Laboratory
Immunogenomics Laboratory Overviewhttp://jcsmr.anu.edu.au/org/dig/immunogenomics/index.php
Immune Tolerance & Signalling Group
Disruptions to the immune responsehttp://jcsmr.anu.edu.au/org/dig/immunogenomics/people/goodnow/research.php
The Immunogenomics Laboratory comprises four
research groups working together to understand
how the human immune system is controlled at the
cellular and molecular level by circuits specified
in our DNA.
Each group focuses on a different element of a
fundamental set of immune system decisions made
by immune system cells: either to fight or to disarm.
The process of deciding which T cell or B cell should
fight, and which should disarm, is key to our ability
to resist infection, parasitism and cancer. Mistakes
in this process result in incurable illnesses. Drugs
and other ways to alter fight or disarm decisions
are needed to improve the success of organ
transplantation and treatment of autoimmune
diseases and metastatic cancer.
This laboratory has pioneered ways to visualise how
fight or disarm decisions are made in cells and the
molecular circuitry guiding them in genetically
modified laboratory mice.
By studying cells from mice with precise changes
in their molecular circuits, we have discovered that
each immune cell must run through a complex
series of fight or disarm checkpoints before it can
be fully launched into an immune response. In some
ways, the process resembles the sequence of fight/
disarm decisions in a military missile launch, which
serve a similar purpose of preventing friendly fire
and optimising targeting against invaders.
This systems approach, coupled with the close
relationship to the human genome sequence,
provides the Laboratory with a unique opportunity
to discover the molecular circuitry that controls
fight/disarm decisions by immune cells.
Nullmutationsthatknockoutrecognitionof
foreignchemicals(‘antigens’)byTcellsexplainrare
immunodeficiencydiseases,butwehaveremarkably
littleknowledgeoftheimmunologicalconsequences
ofmuchmorecommontypesofgeneticvariationthat
yieldintermediatestatesbetween‘wild-type’and‘null’.
Inthelastyear,acollaborationbyHonours
studentOwenSiggsandpreviousPhDstudentsDr
AdrianListon,DrLisaMiosgeandDrAdeleYates
hassystematicallyanalysedtheimmunological
consequencesofasetofinheritedgenevariantsin
Zap70thatproducegradeddecreasesintheefficiency
ofTcellantigenrecognition.
Moderatedefectsinrecognitiondisruptboththe
arminganddisarmingofasubstantialnumberof
Tcells,butthesecellulardefectsaretoleratedat
thesystemlevelsothatrelativelynormalimmune
Professor Chris Goodnow
responsesaremade.Severedefectsdisruptthe
formationandarmingofTcellssoseverelythat
immuneresponsescannotbemade.Atathreshold
betweenthesetwostates,thedisarmingofTcells
iscompromisedtoamuchgreaterdegreethanthe
armingprocess,andthiscellularimbalancecanno
longerbecontrolledatthesystemlevel,resultingin
overproductionoftheIgEantibodiestypicalofallergic
diseaseandproductionofauto-antibodiestypicalof
systemiclupuserythematosus.
Theseresultsilluminatehowgeneticvariabilityinthe
manycomponentsoftheTcellantigenrecognition
pathwaywillcontributetocommonimmunological
diseases.
Immunogenomics Laboratory
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Division of Immunology & Genetics
Division of Immunology & Genetics
Ourresearchstudiesimmunesystemcells
(lymphocytes)whichdefendthebodyagainstdiseases.
Ourworkaimstounderstanddiabetesandlupus,
whichoccurwhenthebodyhasanautoimmune
responsetoanaturallyproducedsubstance,like
insulin,ortoourowncellcomponents.
Therearetwotypesoflymphocytes–TandB.
SpecificallyweareresearchingasubsetofT
lymphocytescalledTfollicularhelper(TFH)cells,
whichdirectBcellstomakeantibodies.TFHandB
cellencountersoccurin
germinalcentres,which
forminspleenandlymph
nodesduringinfections.
Immunityisafinebalance
betweengeneratinga
protectiveresponseto
diseaseswhileavoiding
aninflammatoryresponse
againstcomponentsof
ourownbody,so-calledautoimmunity.Germinal
centresgeneratelong-lastingBcellsandantibodies
againstlife-threateninginfections,however,asTFH
cellsbecomehighlyactivatedthereisanincreased
riskofgerminalcentresdrivingBcellstogenerate
antibodiestriggeringautoimmunediseases.
WehavediscoveredagenewehavenamedRoquin,
whichappearscrucialtorepressingTFHcells,especially
thosewiththepotentialtoreactagainstselftissues.
Roquinmutationsalsoincreasesusceptibilityto
diseasesresemblingtype1diabetesandrheumatoid
arthritis.Intriguingly,Roquinmutationsappearto
protectagainstdevelopmentofamouseformof
multiplesclerosis.
Nowweareinvestigatingwhichmoleculeshelp
RoquinregulateTFHactivity.Wearecharacterising
thesepathwaysinpatientswithlupusanddiabetes.
Wehopethiswillidentifynewapproachesfortreating
thesediseases.
Humoral Immunity & Autoimmunity Group
Dr Carola G Vinuesa
Dangerous liasons between T & B cellshttp://jcsmr.anu.edu.au/org/dig/immunogenomics/people/vinuesa/index.php
Genetic mutations which cause diseasehttp://jcsmr.anu.edu.au/org/dig/immunogenomics/people/hoyne/index.php
T cell Development & Regulation Group
Identifying genes that oppose Type 1 diabetes
Theimmunesystemhasaremarkableabilityto
educatedevelopingTcellsnottorespondtoany
oftheknownselfproteins.Thisisaphenomenon
describedasimmunologicaltolerance.Sometimes
thiseducationprocessgoeswrongthroughinherited
mutationsandself-reactiveTcellsareallowedto
entertheperipheralcirculationwheretheycancause
autoimmunedisease.Weareusingageneticscreen
toidentifymutationsthatcausearapidonsetofType
1diabetesinmice.Wehaveidentified30different
mousestrainsthatcarrydiabetesinducingmutations
andwearetryingtoidentifythosemutantgenes.
Identification of a novel gene involved in alternative splicing
Wehaveidentifiedamousestrainfromourgenetic
screenthathasamutationinanovelgenethat
regulatestheexpressionofspecificformsofacell
surfacereceptorcalledCD45.DifferentsizedCD45
proteins(calledisoforms)existonthesurfaceofaT
cellandtheexpressionofthesedifferentisoforms
isregulateddependingonthestateofcellular
maturation.Themolecularbasistoexplainhowthese
differentCD45isoformsareproducedhaseluded
immunologistsuntilnow.Wehaveunravelledavital
cluetounderstandinghowCD45becomestobe
expressedatthecellsurface.
How do mutant forms of Ikaros cause T cell leukaemia?
Tcellleukaemiacanarisethroughgeneticmutations
thataffectthecontrolofcellgrowth,differentiation
orsurvival.Ikarosisanuclearproteinthatdirects
thedifferentiationofTcells.MutationsintheIkaros
genecanleadtoTcellleukaemiasbutasyetitisnot
understoodwhyorhowthediseasedevelops.
Dr Gerard F Hoyne
Immunogenomics Laboratory
Immunogenomics Laboratory
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Division of Immunology & Genetics
Themolecularvirologylaboratoryaimstodevise
strategiesforthepreventionofdiseasescausedby
flaviviruses,whichincludedenguefever,yellowfever,
JapaneseencephalitisandWestNilevirus.Thereisan
urgentneedworldwideforneworimprovedmethods
forthepreventionandcontroloftheseinfections.
TheMolecularVirologyLaboratorystudiesthe
flavivirusinfectionsatthemolecular,cellular
andwholeanimallevel,usingacombinationof
recombinantDNA,cellbiological,biochemicaland
immunologicalapproaches
tostudyflavivirus
replication,virulence,
pathogenesisand
immunobiology.
Traditionalapproaches
forthedevelopmentof
newvaccinesagainst
flaviviruseshavehad
limitedsuccessoverthe
pastdecadesandtherapeuticanti-flaviviralagents
arenotyetavailable.Studiesaimedatimproved
understandingofthebiologyofflavivirusesare
essentialandmayleadtonovelwaysofpreventing
disease.
Weareinvestigating:
• themoleculardeterminantsandmechanismsfor
flavivirusvirulenceattenuation
• themoleculareventsleadingtoflavivirus
morphogenesisbybuddingatintracellular
membranes
• theroleofcellularandhumoralimmuneresponses
inrecoveryfromorexacerbationofflavivirus
infection
• therisksandbenefitsassociatedwiththeuse
ofJapaneseencephalitisvirusvaccinesinthe
Australiancontext.
Molecular Virology Laboratory
Dr Mario Lobigs
Prevention & control of Flavivirus infectionhttp://jcsmr.anu.edu.au/org/dig/vi-mv/molecular.php
Division of Immunology & Genetics
Weemploymousemodelsofviralinfectiontostudy
immuneresponsestoviralinfectionwhichapply
tohumandisease.Theoutcomeofaninfectionis
dependentnotonlyonthetypeofresponsemounted
bythehost,butalsobytheevasionmechanisms
viruseshaveevolvedtosubverttheseresponses.
Wefoundthatmiceinfectedwithinfluenzavirus
havemassiveamountsofinflammatorycytokines
presentintheirlungs,andthatblockingthese
preventsthedevelopment
ofpneumonia.Wehad
previouslyidentifiednitric
oxide(NO)asacritical
mediatorofpneumonia,
asinhibitionofNO
allowedmicethatwould
havenormallydiedfrom
infectiontorecover.
Interestingly,inhibition
ofNOalsosignificantly
Dr Guna Karupiah
Understanding host-virus interactionshttp://jcsmr.anu.edu.au/org/dig/infimm/index.php
Infection & Immunity Group
reducedtheproductionofinflammatorycytokines
indicatingthatNOactsupstreamofthesecytokines
andisinvolvedintheirinduction.
Poxviruses,includingectromeliavirus(whichcauses
mousepox),encodeproteinsthatinactivatethe
cytokinestumournecrosisfactor(TNF)andgamma
interferon(IFN-γ).WefoundthatviralTNFreceptor
(vTNFR)bindstomembraneTNFtosendasignalin
thereversedirection(reversesignaling)intotheTNF-
bearingcell,whichresultsinswitchingofforonof
specificgenesinvolvedininflammation.Thisindicates
thatvTNFRmodulatesthehostimmuneresponse
throughreversesignaling.Inaddition,usingamutant
ectromeliaviruslackingIFN-γbindingprotein(vIFN-
γbp),wehaveshownthatvIFN-γbpdampensboth
innateandadaptiveimmuneresponses.Henceitmay
bepossibletousebothpurifiedvTNFRandvIFN-γbp
astherapeuticagentsintreatingunrelatedchronic
inflammatoryconditionswhereTNFandIFN-γare
overproduced.
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Division of Immunology & Genetics
TheCancerandVascularBiologyGroupisparticularly
interestedinunderstandinghowbloodvesselshelp
solidcancersgrowandspreadtootherorgans.
Whenprimarycancersarisetheycannotgrowbeyond
1-2millimetresindiameterunlesstheyinducethe
growthofnewbloodvesselsthatsupplythemwith
oxygenandnutrientsandremovetoxicby-products
ofmetabolism.
Similarly,bloodvesselsplayanimportantroleinthe
spreadofcancercellstootherorgans,thecancer
cellshavingtousearangeofdegradativeenzymes
todigesttheirwaythroughbloodvesselwalls,
particularlywhentheylodgeindistantorgans.
TheCancerandVascularBiologyGrouphasbeenable
todeveloprelativelysimplesugar-baseddrugsthat
inhibitbloodvesselgrowthintumoursandblockakey
enzyme,calledheparanase,thataidscancerspread.
Oneofthesedrugs,PI-88,hasreachedPhaseIII
clinicaltrialsincancerpatients.
Thesedrugsarealsobeinginvestigatedaspotential
newanti-inflammatoryagents.
InparallelstudiestheGroupisinvestigatinga
numberofwaysofstimulatingtheimmunesystem
torecognisecancercellsasforeignandeliminate
them.Oneofthesevaccinationapproachesinvolves
inducinganimmunereactiontotumoursresembling
thatwhichoccursinthelungsofpatientssuffering
fromchronicasthma.
Itishopedthatthecombinationofthesenovel
immunologicalanddrug-basedapproachescanbe
usedtoeffectivelycontrolmanycancertypes.
Controlling cancerhttp://jcsmr.anu.edu.au/org/dig/canc-vascbiol/index.php
Professor Chris Parish
Cancer & Vascular Biology Group Division of Immunology & Genetics
The general aims of the group are:
• togeneratenewknowledgerelevanttoour
understandingofthefundamentalpropertiesof
immuneresponsesatthemolecular,cellularand
wholesystemlevel,withparticularemphasison
immuneresponsesagainstviruses;
• tostudyvirus/hostinteractionsatthecellularand
molecularlevelandthroughthisdevisestrategies
forthepreventionofviraldisease;
•toexploretheuseofgammaray
inactivatedviruspreparationsas
inducersofcytotoxicTcellmemoryand
theirefficacyasvaccinesforcontrolof
influenzaandFlavivirusencephalitis.
Inordertounderstandthecomplex
natureofviraldisease,ourinvestigations
focuson:thedifferentfunctionsof
cytolyticeffectormolecules,MHCclass
Iantigenpresentation,Tlymphocyte
Professor Arno Müllbacher
Viral Immunology Group
responsesagainstinfectionwithviruses,bacteriaand
fungi,thecytotoxicTmemoryresponse,virus/host
interactionsinflavivirusinfections,andviralimmune
evasionstrategies.
Weemployalargenumberofvirusmodelsincluding
flaviviruses,poxviruses,influenzaandparainfluenza
viruses,alphavirusesandadenovirusesinthesestudies.
Theavailabilityandestablishmentbyourlaboratories
ofgene-targetedmicedefectiveinimmuneeffector
moleculeshasallowedustolearnimportanthost/
parasiterelationshipsinthecontextofthehost
immuneresponse.
Inaddition,weareexploringtheinterfacebetween
innateandadaptiveimmuneresponses,and
particularlytheroleoftype-Iinterferoninregardsto
sequentialviralandbacterialinfections.
Furthermore,weareemployingourexpertisein
cytotoxicTcellresponsesandinvirus-inactivationto
formulateacross-reactiveandcross-protectiveanti-
influenzavaccine.
Fighting viral diseasehttp://jcsmr.anu.edu.au/org/dig/vi-mv/viral.php
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Apotentialtherapy
thatinhibitstheonset
ofType1diabetesis
beingexploredbythe
Diabetes/Transplantation
ImmunobiologyGroup,
incollaborationwith
ProfessorChrisParishand
theCancerandVascular
BiologyGroup.
Thegrouphasdiscovered
thattheenzymeheparanaseplaysanovelandcritical
roleininitiatingtheautoimmuneresponsethatleads
toType1diabetes.
Inthisformofdiabetesthebordersurroundingtheinsulin-
producingpancreaticisletsisbrokendownbyimmune
cells(insulitis)andtheisletisinvaded,damagedand
preventedfromproducinginsulin.
Collaborativeresearchhasshownthatperlecan–a
heparansulfate(HS)-containingproteoglycan–is
presentintheoutercapsuleorbasementmembrane
surroundingisletsandprotectstheisletfrom
infiltrationbyinsulitisleukocytes.Heparanaseisthe
onlyenzymeknowntobreakdownheparansulfate.
Thegroup’sresearchhasshownthatheparanase
expressionisincreasedseven-foldintheisletsof
pre-diabeticnon-obesediabetic(NOD)miceandat
diabetesonset–normallybetween100and200days
ofageinmice.
In vivotreatmentwithPI-88,apotentinhibitorof
heparananse,protectstheNODmicefromtheonset
ofclinicaldiabetesbysignificantlydelayingthe
progressionofinsulitisintotheislets.
ThesefindingsstronglysuggestthatHSisessentialforthesurvivalofinsulin-producingisletbetacellsandtheconversionfromnon-destructiveinsulitistodestructiveinsulitisinNODmiceisduetotheproductionofheparanasebyinsulitisleukocytes(MNCs).
TheMNC-derivedheparanaseinducesclinicaldiabetesbydegradingtheisletbasementmembraneHSandintra-isletHS,therebyinducingbetacelldemise.OurfurtherstudieswillassessthepotentialforheparanaseinhibitorsasanovelinterventiontherapyintheclinicforrescuingbetacellfunctioninpatientswithnewlydiagnosedT1D.
Diabetes / Transplantation Immunobiology Group
Dr Charmaine Simeonovic
Intervention therapy for Type 1 diabeteshttp://jcsmr.anu.edu.au/org/dig/tranimm/index.php
Division of Immunology & Genetics
NaturalKiller(NK)cells,asmallpopulationofwhite
bloodcells,areessentialcellsforimmunitytoviral
infectionsandcancer.
NKcellssenseaberrantcellsbyrecognisingthelossof
selfproteinsand,throughvariousactivationreceptors,
areabletokillthosecellsdirectly.
Asaconsequenceoftheirinteractionwithvirally
infectedorcancerouscellsNKcellscommunicate
withantigenpresentingcellsthroughtheproduction
ofcytokines.Thisresultsinthesubsequentantigen
specificimmunitybeingbiasedtowardsa
cellularresponse.
Althoughtherehavebeensignificantadvancesin
recentyearsinidentifyingNKcellactivationreceptors,
themoleculestheyinteractwithremainlargely
unknown.Additionally,NKcellsubsetscanbedefined
bytheirexpressionofvariousreceptorsimplying
selectivebiologicalfunctions.
During2006wehavecontinuedourfocusonhuman
NKcells.Inparticularwehavestudiedtheactivation
receptor
NKp30.
Wehave
analysed
expression
ofthe
differentformsofNKp30inNKcellswiththeaim
ofdefiningtheirroleinNKcellfunction.Ifwe
understandthefunctionoftheseproteinsitmay
bepossible,inthefuture,tomanipulatethem.The
moleculesthatthedifferentNKp30proteinsinteract
withremaintobeidentified,andwehavebegunthis
investigationbyproductionofrecombinantformsof
theseproteins.Otherstudieshaveinvestigatedsubsets
ofNKcellsthathaveaco-receptorrepertoiresimilar
tosubsetsofTcells,implyingthattheseNKcellsmay
haveaspecialisedfunction.
Futurestudieswillcontinuetheseandother
investigationsaimedatunderstandingthebiologyof
humanNKcells.
Division of Immunology & GeneticsCancer & Human Immunology Group
Dr Hilary Warren
Natural killer cellshttp://jcsmr.anu.edu.au/org/dig/canc-humimm/index.php
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Rese
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Asthma and Allergy Group
Biomolecular Structure Laboratory
Cancer and Molecular Immunology Group
Chromatin and Transcriptional Regulation Laboratory
Computational Genomics
Computational Proteomics and Therapy Design Group
Cytokine Gene Expression Laboratory
Cytokine Molecular Biology and Signalling Group
Gene Targeting Laboratory
Medical Genetics
Membrane Physiology and Biophysics Group
Molecular Genetics Group
Muscle Research Group
Predictive Medicine Group
Ubiquitin Laboratory
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Groups & Laboratories
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Division of Molecular BioscienceBiomolecular Structure Laboratory
Dr Marco Casarotto
Designing drugshttp://jcsmr.anu.edu.au/org/dmb/biostruct/index.php
Mostprescribeddrugsareaimedattreatingthe
averageindivudual.However,drugdosesthat
areeffectiveinsomeindividualscanbetoxicor
ineffectiveinothers.Ithasbeenreportedthatadverse
drugreactionsarethefifthmostfrequentcauseof
death.Drugsthatareeffectiveinmostpeoplebut
areextremelytoxicinasmallnumberofindividuals
cannotbeusedunlessthepatientsinwhomtoxicityis
likelytooccurcanbeidentified.
TheMolecularGeneticsGroupstudiesthegenetic
differencesbetweenindividualsintheirabilityto
breakdownanddetoxifytherapeuticdrugs.Our
ultimateaimistoprovideteststhatallowthe
personalisedprescriptionofdrugsatsafeeffective
levels.Thedetoxificationofforeignchemicals
involvessimilarprocessestothoseinvolvedinthe
metabolismofmedicines.Ourstudiesarerelevant
totheidentificationofindividualsusceptibilityto
toxicchemicalswithintheenvironment.Theworkis
particularlyfocusedontheinvestigationofenzymes
calledglutathionetransferases(GSTs).Theseenzymes
exhibitawiderangeofgeneticvariabilitythathas
beenshowntoimpactdirectlyonthemetabolism
ofanti-cancerdrugsandtoinfluencetheonsetof
Parkinson’sandAlzheimer’sdiseases.
Division of Molecular BioscienceMolecular Genetics Group
Dr Phil Board
Medication for the individual patienthttp://jcsmr.anu.edu.au/org/dmb/molgen/index.php
Thestructureof
biomoleculeslikeproteins,
DNAanddrugsplaya
vitalroleinallbiological
processes.Byexploring
thestructuresofthese
moleculesweaimto
tacklemanyofthe
diseasesthatconfront
oursociety.
TheworkoftheBiomolecularStructureLaboratory
focusesonawiderangeofbiologicalmolecules
associatedwithvariousdiseases.Oneclassofprotein
underinvestigationformsviralionchannelsandtheir
actionshavebeenimplicatedinAIDS,hepatitisCand
RossRiverfever.
Thelaboratoryteamisendeavouringtomapthe
structureofthesemembraneproteinsanddesign
drugstoblocktheiraction.Membraneproteinsare
relatedtomusclefunctionandplayanintegralrole
inskeletalandcardiacmusclefunction.Structural
elementsoftwoproteins,thedihydropyridineand
ryanodinereceptorsarebeingexploitedtodesign
drugsthattargetheartdiseaseandcorrectskeletal
muscleassociatedconditions.
Thewaytherapeuticdrugsmaketheirwayintocells
posesoneofthemoderndaychallengesofdrug
design.Weareexploringthedeliveryofbiological
cargoessuchaspeptides/proteins,DNA,RNAand
drugcompoundsintoavarietyofcells.Theenzyme
glutathionetransferase(GST)hasbeenshowntobean
effectivevehicleforthedeliveryofthesemolecules.
Thelaboratoryisinvolvedinthedeliveryofmolecules
thatmayholdthekeyintheeffectivetreatmentof
diabetes,cancerandsexuallytransmitteddiseases.
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Division of Molecular BioscienceComputational Proteomics & Therapy Design
Division of Molecular BioscienceMuscle Research Group
Thefocusofourresearchistounderstandhow
proteinscarryouttheirfunctionsinthecell,in
termsoftheirmolecularstructure,interactionsand
energetics,andalsohowthegeneshaveevolvedto
enabletheproteinstoworkinthisway.Apartfrom
answeringfundamentalquestions,ourfindingshelp
tounderstandtheproteins’normalfunctionsand
theirdysfunctionsindisease.Ourstudyapproach
isunusualasweemployinnovativecouplings
ofcomputationandexperimentwhichcantake
advantageofexistingknowledgeandthepowerof
computationalsimulation
andbioinformatics,
andalsocomparative
genomicswhichcan
exploitpubliclyavailable
genomesequenceand
otherdataformodel
organisms,suchasmouse,
chicken,frogandfish,
totrackevolutionary
changesintheproteins.
Professor Jill Gready
A conceptual biology approach to understanding protein function in cellshttp://jcsmr.anu.edu.au/org/dmb/cptd/index.php
Usingthisapproachwehavedeveloped,testedandpatentednewtechnologyforthedesignofmutantswithimprovedcatalyticefficiencyandsubstratespecificityofthemaincarbon-dioxidefixingplantenzyme,Rubisco.Combiningourcomputationalinsightswithstructuralandsequencebioinformatics,andphylogeneticanalyses,wedevelopedanovelstrategy,calledphylogeneticgrafting,formakingpredictionsofmultiplemutationstoincreaseRubisco’sefficiency.Furtherresearchisnowintrainforengineeringcropplantsforgreaterproductivityandspecificfeaturessuchasdroughttolerance,andforbiomassandbiofuelproduction.
Usingasimilarlywiderangeofmethodsinaprojectsystematicallymappingthefunctionalevolutionofthethreeprionprotein(PrP)familygenes(PrP;Doppel,Dpl;andShadoo),werecentlydefinedamechanismforregulatingco-ordinatedtranscriptionofthePrPandDplgenes.Thiscanexplainhowtherelativelevelsofthetwoproteinsarecontrolled,andcanbe“tipped”undercertainconditionsintoastateinducingapoptosisandcelldeathinAlzheimer’sdisease.
TheMuscleResearchGroupisinvestigatingthe
molecularmechanismsthatunderliedefectsin
skeletalandcardiacmusclethatleadtodebilitating
myopathiesandcardiacarrest.
Ouraimistounderstandthemolecularmachinerywithin
theryanodinereceptorcalciumreleasechannelatthe
coreoftheproteincomplexthatdeterminesmuscle
contraction.Theryanodinereceptoristheionchannel
inthemembraneoftheintracellularcalciumstore.
Thechannelreleasescalciumfromthestoreregulating
calciumsignallinginmuscleandtheforceofcontraction.
Defectivesignallingleadstopoormusclefunctionandto
fatalmyopathiesincludingmalignanthyperthermiaand
centralcorediseaseinskeletalmuscleandpolymorphic
ventriculartachycardiaintheheart.
Wearealsoinvestigatingmolecularinteractionsbetween
keyproteinsthatregulatetheamountofcalciuminthe
intracellularcalciumstore.Ourfocusisonthecalcium
bindingproteinwithinthestore,calsequestrin,andits
molecularcommunicationswiththeryanodinereceptor
viatwoanchoringproteins,triadinandjunctin.
Thesignificanceofthisresearchisthatmovement,
respirationandheartfunctionalldependoncalcium
signalling.Thereforetheresultswillfacilitatethe
useofcalciumsignallinginmuscleasaplatform
foravarietyofpurposes.Theseincludereducingthe
debilitatingeffectsofchangesincalciumsignalling
andmuscleperformanceinageingandingenetically-
ordrug-induceddisorders.Theworkwillfacilitate
thedesignofnovelcompoundsfortreatingmuscle
disorders.
Professor Angela Dulhunty
How calcium affects muscle contractionhttp://jcsmr.anu.edu.au/org/dmb/muscle/index.php
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TheComputationalGenomicsGroupundertakes
researchinbioinformaticsaimedatgenome
decryption-identifyingregionsofthegenomewhich
encodefunctionsthatinfluencediseasesusceptibility.
Ourapproachtothischallengeseekstoexploitthe
effectofnaturalselectiononincreasingordecreasing
theamountofgeneticvariationatfunctionally
importantgenomiclocations.
Oneaspectofourresearchinvolvescharacterising
thebackgrounddistributionofgeneticvariationand
theprocessesresponsibleforit.Wehavebeenable
toshowthattheinfluenceoflocalDNAsequence
onlevelsofvariationchangessubstantiallyacross
thegenomeofmammals.Wehaveshownthat
nucleotidesflankedbyaC-Gbasepairmutatemore
rapidlyinregionsofthegenomewheretherearefew
CandGnucleotides.Wesuggestthiseffectmostlikely
originatesfromaninfluenceonproofreadingbythe
DNApolymerasesresponsibleforreplication.
Anotheraspectofourresearchinvolvesexplicitly
evaluatingtheinfluenceofadaptiveevolution
arisingfrominteractionsbetweensequenceresidues.
Illustratingtheseisaclassofmutationsthatcause
humandisease,yetareobservedinotherspecies.Itis
presumedthatthesevariantsoccurinotherspecies
duetocompensatorychangesthatamelioratethe
effectofthemutation.Thisyearwehavedeveloped
newstatisticaltechniquesformeasuringtheseeffects.
Wehaveappliedthetechniquetodatasetsofhuman
disease-causingmutationsandidentifiedthemost
likelycompensatorychanges.Thistechniquehasalso
beenshowntodetectthegeneralinfluenceofprotein
secondarystructureonlevelsofvariation.
Dr Gavin Huttley
Susceptibility to diseasehttp://jcsmr.anu.edu.au/org/dmb/compgen/index.php
Division of Molecular BioscienceThe Computational Genomics Group
Division of Molecular BioscienceCytokine Gene Expression Laboratory
Howgeneexpressioniscontrolledinthecontextof
DNApackagedintothecellnucleusisafundamental
unansweredquestioninbiology.
Itisessentialforthedevelopmentofanorganism
tocontrolgeneexpression.Itisalsocriticalto
controlgeneexpressiontriggeredbyenvironmental
signals–sincegeneexpressioniskeytothecorrect
responseofcellstotheirenvironment,likeanimmune
response.Aberrantgeneexpressionunderliesmuch
humandisease–forexampleautoimmunity,chronic
inflammationandTcellleukaemia.
Weuseimmunesystem
cellstostudythe
molecularmechanisms
ofgeneexpressionin
responsetoenvironmental
signals.Tlymphocytecells
rapidlyandpreciselyalter
theirgeneexpressionin
responsetoinfection.
Professor Frances Shannon
Gene expression & diseasehttp://jcsmr.anu.edu.au/org/dmb/cytogene/index.php
Thisyear,wehavefocusedourresearchontwo
proteinswhichmaytriggerthecellresponse–c-Rel
andZeb.Theseproteinshavebeenselectedbecause
deletingthegenesthatmaketheseproteinshas
severeconsequencesforTcelldevelopmentor
functioninmice.
Wehavediscoveredthatc-Relisanimportant
modulatorofglobalgeneexpressionintheTcell
responsetoimmunesignals.Wehavealsodiscovered
anovelroleforc-RelinTcelldevelopmentthatwill
bethesubjectoffurtherinvestigation.Wehave
shownZebtobespecificandpreciselytimedrepressor
ofgeneexpressioninTcells.
Inotherresearchontherelationshipofgenestructure
(chromatin)togeneexpression,wehaveidentified
novelchromatinsignaturesthatappeartodictatethe
timingofthegeneresponsetoimmuneactivation.
Weareextendingthesefindingstoagenome-wide
investigationofchromatinstructureacrossinducible
genesinTlymphocytes.
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Division of Molecular BioscienceMembrane Physiology & Biophysics Group
Chromatin & Transcriptional Regulation Laboratory Division of Molecular Bioscience
Oneofthemostamazingengineeringachievements
innatureishowovertwometresofgeneticmaterial
(DNA)canbecompactedandsqueezednearlya
milliontimestofitintoahumancell.Theremarkable
structurethatachievesthisisthechromosome.
ThisastonishingpackagingofDNAthatproduces
achromosomeisachievedbyacomplexschemeof
folding.DNAisfirstwrappedaroundamixtureof
proteins(calledhistones)toformacompleteunit
knownasanucleosome.About30millionofthem
arerequiredineveryhumancelltocompactour
DNA.Achromosomeisahighlyvariedstructure
consistingofalineararrayofnucleosomesfoldedto
differentextentstoformdistinctdomains.Compacted
domainspreventunwantedgenesfrombeingused
whilemoreopendomainsallowtherightgenestobe
utilised.Specificdomainsalsokeeptheendsofthe
chromosomesstableandenableachromosometo
copyitselfeverytimeourcellsdivideandgrow.
Howachromosomeisdividedintothesedifferent
compartmentsremainsamystery,buttoworkout
thisbasicprocessisnecessarytofullyunderstand
developmentaldisordersanddiseasestateslikecancer.
Byexaminingthestructureofchromosomesinliving
cellscombinedwiththedevelopmentofasystem
whereitispossibletoassembleaverysmallpartof
chromosomeinatesttube,ourgrouphasprovided
newinformationonhowchromosomesareput
togetherbyshowingthatalteringthebiochemical
makeupofanucleosomewithvariantformsofthe
histonesplaysakeyroleinestablishingfunctionally
specialisedchromosomaldomains.
Chromosomes – the fundamental units of lifehttp://jcsmr.anu.edu.au/org/dmb/chromatin/index.php
Dr David Tremethick
Ourbraincommunicatesusingelectricalsignalswhosebalanceiscriticalinnormalbrainfunction.Theseelectricalsignalsaregeneratedthroughtheactivationofspecificionchannelsinthecellmembrane.
Thedynamiccontrolofionchannelnumbersandtheirsubcellulardistributionisfundamentaltonervoussystemdevelopment,circuitformationandrefinement,andpathologicalprocesses – likedepression,anxiety,insomniaandepilepsies.
Ourresearchisdirectedatunderstandingtherelationshipbetweentheinfluenceofreceptor
cellularlocalisationandtheeffectofdrugsonGABAAreceptors,themajorinhibitoryneurotransmitterreceptorinthebrain.
GABAAreceptorsareused,forexample,whenwesleeporarerelaxed,bycalmingbrainactivityandarethetarget
ofanarrayofprescribeddrugs.ByidentifyingthecomponentsthatinfluenceionmovementthroughGABAAreceptorswewillbetterunderstandthedrugs’impactonGABAAreceptors.
OurlatestworkhashelpedtoidentifyapreviouslyunknownmechanismwherecontrollingthelocaldensityofspecificGABAAreceptorsinthemembraneenablesthesizeoftheinhibitorysignaltobemodulatedbothbyagonistanddrugs.
Theunderlyingmolecularmechanismweproposeinvolvestheco-ordinatedopeningofadjacentreceptors,challengingtheclassicalviewofionchannelgating.
ItmayemergethatthenatureanddegreeofreceptorclusteringisawayinwhichaneuronisabletomodulatetonicGABAergicinhibition,byprovidingastrongandco-ordinatedresponsetoinhibitoryneurotransmittersandneuromodulators.Thismayunderlietheprincipaleffectsofdrugssuchas
benzodiazepinesandgeneralanaesthetics.
Dr Louise Tierney
Receptors in the control of brain functionhttp://jcsmr.anu.edu.au/org/dmb/membrane/index.php
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Asthmaiscausedbyabnormalimmuneresponsesto
allergenssuchaspollensanddustmites.However,
asthmaisalsorelatedtothegeneticmakeupofan
individual,sothatparentswhohaveasthmaare
morelikelytohavechildrenwhoalsohaveasthma.
ThegenesinourDNAencodeproteinsthathavevery
diversefunctions.Forexample,someproteinsare
receptorsthatdirectcellularresponsestoexternal
stimuli.Otherproteinsfunctionasenzymes,which
areabletomodifyothermolecules.Theaimofour
researchistounderstandhowgeneticvariation
changesthefunctionof
proteinsandenhances
theriskofdeveloping
asthma.
TheIL-4Rαreceptoris
foundoninflammatory
cells.However,asthmatics
aremorelikelytohave
aformofIL-4Rαthat
stimulatesanexaggerated
immuneresponse.Wehaveshownthatchangesin
thisreceptorintensifiesinflammationintheallergic
lungandthewayinwhichallergensstimulate
immunecellstoreleasefactorsthatdamage
theairways.
Comparedtonon-asthmatics,cellsliningthelung
inasthmaticsaremoresusceptibletodamageby
toxinssuchasthosefoundinairpollutantsand
cigarettesmoke.GlutathionetransferasePi(GSTP)is
anenzymethatinactivatestoxicmetabolitesanda
geneticvariantofGSTPisknowntoenhancetherisk
ofdevelopingasthma.Ourstudieshaveshownthat
GSTPplaysacriticalroleininhibitingthedevelopment
ofallergicinflammationandabnormalrespiratory
functioninthelung.
Collectively,ourstudiesareconstructinganintegrated
pictureofhowchangesinourgeneticmakeupenhance
thelikelihoodofasthma.Inthefuture,thisinformation
willenablebettertargetingofmedicationsthatprevent
oralleviatethesymptomsofasthma.
Dr Dianne Webb
Genes & asthmahttp://jcsmr.anu.edu.au/org/dmb/allergy/index.php
Asthma & Allergy Group Division of Molecular Bioscience
How cytokines influence the immune systemhttp://jcsmr.anu.edu.au/org/dmb/cytomol/index.php
Professor Ian Young
TheresearchofourGroupcentresonthreecytokines
(IL-3,IL-5andGM-CSF)whichregulateimmune
responsestoinfections.
Thesehormonelike-proteinsstimulatetheformation
andactivationofwhitebloodcellsinvolvedinhost
defenceagainstparasitesandinallergicinflammation
indiseasessuchasasthma.Wewishtounderstand
howthecytokinesmodifythegrowth,maturation
andactivationofbloodcellsbybindingtotheircell
surfacereceptors.Tothisendwehavedetermined
the3Dstructureofthemainsignallingreceptor(hβc)
sharedbythesecytokinesusingX-raycrystallography.
Guidedbythenewstructure,wehavemadechanges
topotentiallyimportantaminoacidsinthereceptor
todeterminetheirrole.
Ourrecentstudiesofreceptorhβcandtheclosely
relatedβIL-3receptorhaveindicatedtherearetwo
modesofreceptoractivationwhichinfluencewhether
bloodcell-formingstemcellsundergomaturation
orself-renewalinresponsetoIL-3.Excessiveself-
renewalanddefectivematurationarethehallmarksof
leukemiaanditisthereforeimportanttounderstand
howtheseprocessesareregulated.
Ofrelevancetoourresearchisthefindingthatthe
specificreceptorrequiredforIL-3signalling(IL-3Rβ)
ispresentinabnormallyhighlevelsonthesurfaceof
leukemicstemcells.Ourfuturestudieswillinvestigate
thepossibleinvolvementoftheIL-3receptorsystem
inmyeloidleukemia.
Division of Molecular BioscienceCytokine Molecular Biology & Signalling Group
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Rese
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Autonomic Neuroeffector Transmission Laboratory
Blood Vessel Laboratory
Brain Modelling Laboratory
Cerebral Cortex Laboratory
Developmental Neurobiology Laboratory
Movement and Memory Laboratory
Neuronal Network Laboratory
Neuronal Signalling Laboratory
Synapse and Hearing Laboratory
Visual Neuroscience Laboratory
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Groups & Laboratories
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Theolfactorycortexisarelativelysimplebrainregion
thatdoesacomplexjob–ithelpsustorecogniseand
rememberthemanyodoursweencounterindailylife.
TheCerebralCortexLaboratoryaimstounderstand
howtheolfactorycortexmakessenseofodours,
whichinturnmayleadtoabetterunderstandingof
brainfunction.
Thelaboratorystudiesthepropertiesofnervecells(or
neurons)intheolfactorycortexofmice.Neuronsare
thebuildingblocksofthebrain,sobyunderstanding
neuronsweareseveralstepsclosertounderstanding
howthebrainworks.
Theadvantageofstudyingtheolfactorycortexis
thatitsstructureissimplerthanotherbrainregions.
Wehopethiswillmakethesenseofsmelleasierto
explain,leadingtonewinsightsintobothnormaland
pathologicalbrainactivity.
In2006westudiedtheneuronsthatreceivemostof
theinputtotheolfactorycortex.Wehavediscovered
anunexpecteddiversityinthepropertiesofthese
Division of NeuroscienceCerebral Cortex Laboratory
Dr John Bekkers
Nerve cells underlying the sense of smellhttp://jcsmr.anu.edu.au/org/dns/cortex/index.php
neurons,allowingustomakepredictionsabouttheir
likelyrolesinolfactoryprocessing.
Wealsomadesomeexcitingdiscoveriesaboutanother
classofneuron,theinhibitoryinterneurons,which
mayactas“pacemakers”ofelectricalsignallinginthe
olfactorycortex.Weidentifiedatleastfivedifferent
typesofinterneuron,basedonshape,location,
molecularmarkersandelectricalproperties.
Futureworkwilltestthehypothesisthateach
interneuronclassisspecialisedtoperformaparticular
taskwhendecodingsmells.
TheBloodVesselLaboratoryaimstodeterminetheroleofionchannelsandcellularcouplinginvascularfunctionundernormalconditions,sowecanthenbegintounderstandwhatchangesoccurduringvasculardisease.
Invascularfunctionionchannelsaffectbloodvesseldiameterandbloodflowbyallowingtheflowofpositiveandnegativeionsthroughtheplasmamembraneofcells.
Specialisedionchannels–gapjunctions–mediatecellularcouplingbyconnectingthecytoplasmofadjacentcellsallowingthecoordinationofcellular
responses.Thecoordinatedbehaviourofsmallarteriesisfundamentaltotheregulationofbloodflow,bloodpressureandadequatetissueperfusion.
Arteriolartoneisdeterminedbyabalancebetweenstimuliwhichpromoteconstrictionofbloodvessels(vasoconstriction)orrelaxationofbloodcells(vasodilation).Disruption
ofthisbalanceinfavourofvasoconstrictionoccursduringhypertensionanddiabetes,oftenresultingfromdysfunctionofcellsinthevascularwall.
Wehavedemonstratedthatcellcouplinglinksthemusclecellsofcerebralarterieswiththeinnerendothelium.Thiscouplingisessentialforcoordinatedoscillationsinvasculardiameter,whichmayprotectthebrainagainstinjuryfrombloodpressurefluctuations.Wehavealsoidentifiedanovelionchannelwhichplaysanimportantroleindeterminingvasculartoneundernormalconditions.Wehavefoundthatupregulationofanotherionchannelinspecificarteriescontributestothecellulardysfunctionfoundinhypertension.
Finally,wehaveshownthatchangesincellcouplingoccurinrenalarteriolesduringdiabetesandthesemayresultfromchangesinanenzymeessentialfortheformationofapotentvasodilator.Upregulationofthisenzymeoffersprotectionagainstchemically-induceddiabetes.
Ourstudiesprovideevidencethatcellcouplingandionchannelsareimportantinsettingvasculartoneandcontributingtovasculardysfunctionduringdisease.
Blood Vessel Laboratory
Professor Caryl Hill
Division of Neuroscience
How blood flow regulation controls blood pressurehttp://jcsmr.anu.edu.au/org/dns/bloodvessel/index.php
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ResearchintheVisualNeuroscienceLaboratoryaims
toexplainthecellularandmolecularmechanismsof
vision,sowecanbegintounderstandwhyitfalters.
Humanscanseeoveranenormousrangeoflight
intensities.Ourrodphotoreceptorsareusedunder
twilightandmoon-lightlevels,whereasourconesare
usedinbrighterlightandmediatecolourvision.
Wehaveinvestigatedrecoveryafterintenselight
exposures,byrecordingelectricalactivityfromthe
livinghumaneye.We
haveshownthatthe
slownessofrecoveryis
presentevenatthefirst
processingstageinthe
retina(theretinal
bipolarcells).
Byrecordingtheelectrical
activityofsinglerod
photoreceptorcellstaken
fromtheeyesofmiceandzebrafish,ourresearchers
arelearningaboutthemolecularmechanismsthat
permitthesecellstorecoverrapidlywhenlight
isextinguished.
Throughcollaborationswithoverseascolleagues
wehaveprovidedamathematicalmodelofthe
time-courseoftheelectricalresponseofcone
photoreceptorsinthelivinghumaneye,showinghow
humanconesareabletocontinuefunctioning,even
atextremelyhighlightintensities.
IncollaborationwithcolleaguesinPerth,anew
scanninglaserophthalmoscopehasbeendeveloped
thatcanmeasurethelevelofvisualpigment
rhodopsininthelivingeye.
Thisresearchhasadvancedunderstandingofhowcells
atthebeginningofthevisualsystemrespondtolight,
howtheyrecoverfromlight,andhowtheyprocess
visualinformation.
Visual Neuroscience Laboratory Division of Neuroscience
Division of Neuroscience
Theworkofthislaboratoryisaimedatunderstanding
thebiologicalbasisoflearningandmemory.
Transmissionattheconnections(synapses)between
braincells(neurons)canbeenhancedbyintense
activity.Thisenhancement,knownaslong-term
potentiation(LTP),isbelievedtounderlielearningand
memoryinthebrain.LTPcanlastfordifferentperiods
oftime,justlikememories.
AllformsofLTPrequireanelevationofcalciuminside
theneuron.Wehaveshownthatelevationofcalcium
indifferentpartsoftheneurondeterminehowlong
LTPcanlast.
Morerecentlywehaveinvestigatedtherelationships
betweentheelectricalactivitiesatthesynaptic
connectionversuscell-wideactivity(actionpotentials)
thatarerequiredtotriggerLTP.
Whileshort-lastingLTPdoesnotrequireaction
potentials,longer-lastingformsdo.Infact,short-
lastingLTPcanbeconvertedintoalong-lastingform
byactionpotentials.
Thistypeofresearchintothemechanismsunderlying
LTPwilleventuallyhelpourunderstandingofhow
differentformsofmemoryaremaintainedby
thebrain.
Professor Trevor Lamb
Movement & Memory Laboratory
Exploring visionhttp://jcsmr.anu.edu.au/org/dns/visual/index.php
Brain mechanisms of learning & memoryhttp://jcsmr.anu.edu.au/org/dns/movememory/index.php
Dr Clarke Raymond
Professor Steve Redman
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Division of Neuroscience
Division of Neuroscience
Hirschsprung’sdiseaseisacongenitalcondition
affectingthebowel,causedbytheabsenceofnerve
cellsinthedistalbowelandischaracterisedbythe
failureofrelaxationandobstruction.
Hirschsprung’sdiseaseismostlycausedbythe
mutationofagene(theendothelinreceptorBgene,
ERTB).Inadditiontobowelobstruction,neurological
symptomsareoftenassociatedwithHirschsprung’s
disease,includingmentalretardation,nervedeafness
andseizures.However,littleisknownaboutthebrain
changesatcellularand
molecularlevelsin
thiscondition.
Toaddressthisquestion,
theBrainDevelopment
Laboratorystudiedthe
brainsofaratwith
Hirschsprung’sdisease.
Usingthein vivo cell
labellingtechnique
wediscoveredathree-to-fivefolddecreaseincell
proliferationinthecerebellumandhippocampus
ofthediseasedrat,comparedwithnon-diseased
littermates.Thefunctionalsignificanceofthiscell
reductionisyettobedetermined.
Therewasalsoatwo-foldincreaseinthenumbers
ofprogrammedcelldeathinthecerebellumand
hippocampusoftherat.Weanalysedthelevelsof
severalneuronalgrowthfactorsbutdidnotdetectany
changesintheHirschsprung’srats.
Thisstudyrevealscellularchangesinthebrains
ofdiseasedratsandhasdirectrelevancetoour
understandingoftheneurologicaldeficitsof
Hirschsprung’sdiseasepatientswiththe
ERTBmutation.
Ourfutureresearchwillinvestigatethemechanism
ofdecreasedcellbirthandincreasedcelldeathinthe
brainandthefunctionalconsequencesof
thesechanges.
Dr Zan-Min Song
Brain Development Laboratory
Understanding the effects of Hirschsprung’s diseasehttp://jcsmr.anu.edu.au/org/dns/braindev/index.php
Theinternalmechanismsusedbythespinalcordto
produceeverydaymovement–walkingandrunning
–arenotwellunderstood.
IncollaborationwithProfessorRobBrownstoneand
DrJenniferWilsonatDalhousieUniversityinCanada,
wehaveinvestigatedthepropertiesandnetwork
behaviourofaclusterofinterneurons(Hb9+)that
maybeinvolvedinthecontrolofthis
rhythmicmovement.
Thisclusterofinterneuronscanfireactionpotentials
simultaneously.Thissynchronousandrhythmic
activitydependsonelectricalcouplingbetweenthe
Hb9+interneuronsandotherneighbouringneurons.
Theinterneuronsalsoreceivecommonsynapticinput
whichmodulatesactivity.
Importantly,theoutputofthespinalcordcontrolling
movementrelatedmuscleactivitycanalsooccurat
thesametimeasactivityintheseinterneurons.It
suggestsHb9+interneuronsworkinawaythatwould
Professor Steve Redman
Dr Anna Cowan
Movement & Memory Laboratory
Spinal cord cells which control movementhttp://jcsmr.anu.edu.au/org/dns/movememory/index.php
berequiredofneuronsinvolvedinnetworksthat
producelocomotoractivity–ormovement.
Wehopetodiscoverwhetherthereisaconnection
betweenthelocomotoractivityandthisclusterof
interneuronsandunderstandhownetworksofneurons
inthespinalcordenableustowalkandrun.
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Researchintheneuralnetworklaboratoryis
discoveringthebuildingblocksofbrainfunctionthat
couldonedayleadtothedevelopmentofcuresfor
illnesseslikeAlzheimer’sdisease.
Ourworkhasledtoabetterunderstandingofhow
informationisprocessedinthebrainandgiven
insightsintothemakeupofthecellswhichdothis
importantwork.
Communicationbetweencellsinthebrainoccursin
areascalledsynapses.We
havemadesignificant
progresstogaininsight
intohowtheelementsof
thesynapsesarechanged
ondemandandhow
thesechangesaffectthe
informationtransfer.
Wehavediscoveredthere
aretwokindsofsynapse,
simpleandcomplex.Simplesynapsestakelonger
toregeneratesowhenstimulatedtheywillquickly
diminishtheirresponse.Complexsynapses,however,
areabletoaccesscalciumstorestoregeneratefaster
andcanmaintainareactiontostimulusforlonger.
ItispredictedthatintheAlzheimer’sbrainthereare
moresimplesynapsesthancomplexones,thoughthis
isresearchforthefutureinthelaboratory.
Theresearchatthelaboratoryhasalsouncovereda
waytopharmacologicallyconvertsimplesynapsesto
complexsynapsesandviceversa,whichmay,ifthe
predictionsabouttheAlzheimer’sbrainarecorrect,be
abuildingblocktoadvancesinthisarea.
Thenextstepforthisresearchistoinvestigatethe
molecularmechanismsinvolvedandwhatdetermines
thedynamicsinalivingbrain.
Division of Neuroscience
Division of Neuroscience
Neural Network Laboratory
Associate Professor Christian Stricker
Simple & complex brain processeshttp://jcsmr.anu.edu.au/org/dns/neuronetwork/index.php
TheNeuronalSignallingLaboratoryconductsbasic
researchonhownervecellsinthebrainprocess
information.Thisworkinvolvesrecordingactivity
fromsinglenervecellsusingbothelectricaland
opticaltechniques.Duringthepastyearwehavebeen
investigatingthefollowingissues:
Electrical properties of dendritic spines
Communicationbetweennervecellsinthebrain
occursatspecialisedregionscalledsynapses.Inthe
cortex,themajorityofsynapsesaremadeontosmall
(onethousandthofamillimetre)
processescalleddendriticspines.Due
totheirsmallsizetechnologyhas
notallowedthefunctionofdendritic
spinestobeinvestigateddirectly
before.However,wearenowableto
studythemusingopticaltechniques
byrecordingchangesinmembrane
potentialinsinglespinesusing
confocalmicroscopy.
Cellular mechanisms underlying absence epilepsy
Oneofthemostcommonformsofepilepsyin
childrenisabsenceepilepsy.Wehavebeenstudying
thecellularmechanismsunderlyingthisdiseaseinan
animalmodel.Wehavefoundthatthereisa50per
centreductioninaparticularproteincalledHCN1in
thecortexoftheseanimals.Importantly,wefindthat
thisreductionofHCN1leadstoincreasedexcitability
ofthecortex,andthereforemayplayaroleincausing
absenceseizures.
Cortical micro-architecture
Thecerebralcortexiscriticalforconsciousperception
ofsensoryinformation–howwerecogniseaglassas
aglassorapersonfromthesoundoftheirvoice.But
howthecerebralcortexdoesthisisnotunderstood.
Wehaverecentlydiscoveredthattheinteraction
oftwosetsofsub-networkswithinthecortexmay
enablethemainoutputofthecortextocombine
differentfeaturesofasensorystimuluswhichresults
intheperceptionofsensoryinformation.
Associate Professor Greg Stuart
Neuronal Signalling Laboratory
Information processing in the brainhttp://jcsmr.anu.edu.au/org/dns/neurosignal/index.php
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Cochlea-relateddeafnesscausessignificantchangesin
auditorycentersofthebrain.Revealingthesechangesis
importanttoourunderstandingoftheauditorysystem,
andthecontinueddevelopmentofcochlearimplantsand
othertherapiestoovercomedeafness.
Hearingisahighlydevelopedsense,requiring
extremelyrapidandcomplexprocessingofsignals
transmittedtothebrainviatheauditorynerve.
Connectionsbetweenauditoryneuronsinvolvedin
thelocalisationofsoundsrepresentsomeofthemost
powerfulandfastestsynapsesinthemammalian
brain.Itisgenerallyassumedthatsensoryinputto
thedevelopingbrainshapesthestrengthofsynaptic
connectionsandthemembranepropertiesofneurons.
Insightintotheroleofactivityinregulatingsynaptic
transmissionandneuronalmembranepropertiescan
begainedbystudyingtheeffectsofeliminatingor
reducingauditorynerveactivityie.deafness.Weare
studyinganaturallyoccurringstrainofmice,dn/dn,
withamutationinatransmembraneproteinin
cochlearhaircellswhichrenderstheseanimalsdeaf
frombirth.
Ourexperimentshaverevealedthatthesynapse
betweenauditorynervefibersandneuronsinthe
brainstemismuchstrongerindeafmice,andthatthe
postsynapticneuronsaremuchmoreexcitableindeaf
mice.Recently,wehaveshownthattheexcitability
ofauditoryneuronscanbesignificantlymodifiedin
normalhearingmiceinresponsetosoundstimuli.
Ourfutureexperimentsareaimedatunderstanding
themechanismsunderlyingthisplasticityinthe
centralpathwaysoftheauditorysystem.
Division of NeuroscienceThe Synapse & Hearing Laboratory
Professor Bruce Walmsley
Congenital deafnesshttp://jcsmr.anu.edu.au/org/dns/synapse/index.php
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Globallyhypertension(highbloodpressure)is
theleadingcauseofdeath,causingheartattack,
stroke,kidneyfailure,andothercomplications
suchasblindnessandprematurity.TheHighBlood
PressureResearchUnit(HBPRU)undertakesbasic
andclinicresearchintohypertension,inparticular
thedevelopmentofhypertensioncausedbyadrenal
glucocorticoidhormones.
Wehavefoundglucocorticoid(steroidhormone)-
inducedhypertensionrelatestoalterednitricoxide
(NO)productionandfunctionandisassociatedwith
elevatedreactiveoxygenspecies(ROS),whichact
bymoppingupvasodilatorNO.Ourstudiessuggest
animbalanceofNO(deficiency)andROS(excess)
isimportantinthecausationofglucocorticoid
hypertensionduebothtonaturallyoccurringand
syntheticsteroids.Weareinvestigatingarangeof
strategiesrelevanttotheapparentimbalancebetween
NOandROS.
WehavedemonstratedthatL-arginine,aprecursor
fortheNOproducingenzymeNOsynthaseand
theantioxidantstempol,apocynin,folateandN-
acetylcysteinepreventandreversesteroid-induced
hypertensionwhileallopurinolandvitaminsCandE
hadnoeffect.Weareidentifyingagentsthatprevent
and/orreverseglucocorticoid-hypertensionintherat
whichareappropriateforuseinclinicaltrials.
OurcollaborationwithAssociateProfessorKevin
CroftandDrTrevorMoriattheUniversityofWestern
Australiahasenabledustomeasuremarkersof
systemicoxidativestressandinvestigatetheroleof
20-hydroxyeicosatetraenoicacid(20-HETE),apotent
constrictorinsmallarteries,inglucocorticoid-induced
hypertension.Wearealsostudyingthegenetic
modificationsinducedbyglucocorticoidusingmicro-
arrayandRT-PCRincollaborationwithProfessor
FrancesShannonandDrRubyLin(TheUniversityof
NewSouthWales).
InanongoingcollaborationwithDrGeorgeMangos
andAssociateProfessorJohnKelly(StGeorgeHospital,
Sydney),clinicalstudiesarebeingconductedinto
cortisol-inducedhypertensionandtheeffectof
syntheticsteroidsonbloodvesselfunction.
Theresultsofourstudieswillhelpunderstanding
ofthemechanismsbywhichglucocorticoidsinduce
hypertensionandhavemajorimplicationsfor
treatmentofsteroid-inducedhypertension,and
possiblybroaderimplicationsforourunderstanding
andtreatmentofso-calledessentialhypertension.
Head of Unit Professor Judith A Whitworth
Professor Judith Whitworth
Dr Yi Zhang
Steroid hormones & high blood pressurehttp://jcsmr.anu.edu.au/org/hbpru/index.php
High Blood Pressure Research Unit
Staff & Student Achievements Degrees, Prizes & Awards
AmajorstrategicgoalofJCSMRistoprovideoutstanding
trainingandmentoringformedicalresearchersofthefuture.
Manyofouracademicstaffsupervisepost-graduatescholars
throughtheirstudiesleadingtoHonours,MastersandPhD
degrees.
JCSMRstaffandstudentscontinuetobehonouredand
acknowledgedthroughawardsandprizespresentedbylocal,
nationalandinternationalorganisations.
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Congratulations to our students who have successfully completed their study during 2006
Degrees
PhD degrees awarded in 2006YA AbdellatifModulation of the skeletal muscle ryanodine receptor by GSTM2-2
H AlonsoComputer modelling and simulations of enzymes and their mechanisms
AM De MestreRegulation of heparanase transcription
JM HarrisonModulation of vaccine responses by genetic adjuvants
MY HyunCharacterisation of novel ligand binding affinity for murine macrophage C-type lectin and dendritic cell immunoreceptor
R KhouryPersistent sodium channels and hypoxia
CEL LimMurine glutathione transferase zeta deficiency
TL LuuFactors influencing the single-channel properties of recombinant GABAA receptors
KE PetersInvestigation of a second inflammatory bowel disease susceptibility locus (IBD8) on chromosome 16
BJ ScottEvolution of the Gerbich native allele of glycophorin C: Co-evolution of malaria and its human hosts
MC TaylorFunctional characterisation of the mammalian deubiquitylating enzyme, USP14
JP WoodallThe ontogeny of interferon-gamma responses in the fetal lamb
O ZeidCalcium buffering in spinal motoneurones
J ZhangConnexin expression in the renal vasculature: Role of endothelial nitric oxide in normal and diabetic conditions
J ZhouThe molecular mechanism of H2A.Bbd in chromatin transcriptional regulation
Honours degrees awarded in 2006
J Altin
N Botelho
G Chua
K Couchman
C Gyngell
Y Ho
B Kong
K Lam
J Ng
N Schultz
B Sivakumar
I Sivalingam
A Subramaniam
EJ Tan
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Awards 2006
RT BakerAusBiotech Canberra and Region Biotech Summit : Second Prize for High-level expression and purification of authentic recombinant proteins
S DayTravel Grant to attend the AIDS Vaccine 2006 Conference, Amsterdam, The Netherlands
J EllisonANU Environmental Achievement award
J EllyardAustralasian Society for Immunology (ACT Branch) Student Travel Bursary to attend the Annual Conference of the Society, Auckland, New Zealand
C GoodnowAustralian Research Council Federation Fellowship
T LambThe 2006 Proctor Medal of the Association for Research in Vision and Ophthalmology for outstanding research in the basic or clinical sciences as applied to ophthalmology
A ListonFrank Fenner Medal: Most outstanding thesis submitted in JCSMR during 2005
S OngJacquot Research Entry Scholarship for 2007
L PalmerAmerican Society for Neuroscience Graduate Student Travel Award to attend the Society for Neuroscience 36th Annual meeting in Atlanta, GA, USA
I PoonAustralasian Society for Immunology (ACT Branch) Student Travel Bursary to attend the Annual Conference of the Society, Auckland, New Zealand
I SakalaAustralasian Society for Immunology (ACT Branch) Student Travel Bursary to attend the Annual Conference of the Society, Auckland, New Zealand
L SimsonAusBiotech Canberra and Region Biotech Summit : First Prize for Enhancing Adult Stem Cell Mobilisation Using Small Anionic Glycan Mimetics (AGMs)
E Sutcliffe2006 Ruth Gani Memorial Travelling Fellowship for Human Genetics Australian Society of Medical Research Domestic Travel Award
D YuAustralasian Society for Immunology (ACT Branch) Student Travel Bursary to attend the Annual Conference of the Society, Auckland, New Zealand Australasian Society for Immunology New Investigator Award: Annual Scientific Meeting, Auckland, New Zealand
Professor Frank Fenner awards Dr Adrian Liston the Fenner Medal for the most outstanding thesis presented in The John Curtin School of Medical Research in 2005.
Professor Ed Pugh (left) and Professor Trevor Lamb (right) following the award of the Proctor Medal of the Association for Research in Vision and Ophthalmology (ARVO).
Prizes and Awards 2006Prizes and Awards presented to JCSMR staff and students during 2006
Prizes and Awards
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Stage 1 of the new JCSMR building,
completed in July 2006, has won a
number of building awards. Melbourne
architects Lyons designed the
building with state of the art research
laboratories and facilities and included
design elements to represent the
biomedical nature of the
building’s purpose.
Project managers Hindmarsh were
awarded the 2006 ACT Master Builders
Project of the Year, and subsequently the
MBA National President’s Award.
Building Awards
Top: From the foyer, the view out the front entrance of the new building takes in the campus across South Oval.
Bottom: The wide sweeping staircase and front façade of the award winning Stage 1 of the new JCSMR Building.
The twisted blades are an architectural representation of the DNA helix.
Research Collaborations & Visitors to JCSMR
StaffandstudentsofTheJohnCurtinSchoolofMedical
Researchcontinuetoenjoyclosecollaborativetieswith
colleaguesacrossDivisionswithintheSchool,andwithother
scientistsatTheAustralianNationalUniversity.
JCSMRresearchersalsoenjoyclosescientificassociationand
collaborationwithcolleaguesthroughoutAustraliaandthe
world.Someofthesecollaborativeresearchventuresarelisted
here.
Inaddition,wehavethepleasureofwelcomingvisitorsfrom
local,nationalandinternationaluniversitiesandresearch
instituteswhocometoJCSMRtopresentseminarsorworkon
collaborativeresearchprojectswithinourlaboratories.
The John Curtin School of Medical Research Annual Review 2006
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06 Research Collaborations 2006
Dr RT BakerZinc fingers in deubiquitylating enzymesDr J Mackay School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, NSW
Dr JM BekkersInfluence of the dendritic tree on the firing properties of neuronsProfessor M Häusser Wolfson Institute for Biomedical Research, University College, London, UKSynaptic transmission in neuronal cultures from GAD67-GFP transgenic miceDr Y Yanagawa and Professor K Obata Gunma University, Maebashi City, Gunma, Japan, and RIKEN BSI, Wako, Saitama, JapanRole of Septin-3 in the synaptic vesicle cycleProfessor P Robinson Children’s Medical Research Institute, Sydney, NSW
Dr E BertramRole of T cell costimulation in generation of TCR diversity and cytokine production following influenza virus infectionDr S Turner and Professor P Doherty Department of Microbiology and Immunology, The University of Melbourne, Melbourne, VICRole of TNF members LIGHT and 4-1BBL in T cell costimulationProfessor TH Watts Department of Immunology, University of Toronto, Toronto, CanadaRole of STAT-1 in EAEDr D Willenborg Neurosciences Research Unit, The Canberra Hospital, Canberra, ACT
Dr E Bertram and Dr P ManaRole of TNF family member LIGHT in EACDr D Linares and Dr D Willenborg Neurosciences Research Unit, The Canberra Hospital, Canberra, ACT
Dr E Bertram and Professor C Goodnow Role of CARMA-1 in T cell regulation and allergyDr M Cook The Canberra Hospital, Canberra, ACT and Phenomix Australia, Canberra, ACT
Professor PG BoardDetermination of glutathione transferase structuresProfessor M Parker St Vincent’s Medical Research Institute, Melbourne, VICFunction of Zeta class GSTsProfessor MW Anders Department of Pharmacology and Physiology, University of Rochester Medical Centre, Rochester, NY, USA
Studies of GST knock out miceDr J Dahlstrom Department of Anatomical Pathology, The Canberra Hospital, Canberra, ACT
Dr MG CasarottoStructural studies into the mechanism of dihydrofolate reductaseProfessor G Roberts Centre for Mechanisms of Human Toxicity, University of Leicester, Leicester, UKDr J Basran Department of Biochemistry, University of Leicester, Leicester, UKChitinase and chitin binding proteinsDr C Vorgias Biology Department, Athens University, Athens, GreecePeptide activators of the ryanodine receptorProfessor I Toth Pharmacy Department, The University of Queensland, Brisbane, QLD Effects of drugs that block Vpu ion channels studied with NMR techniquesProfessor T Watts and Dr W Fischer Biomembrane Structure Unit, University of Oxford, Oxford, UK
Dr P CooperAdjuvant activity of microparticulate inulinProfessor N Petrovsky Department of Diabetes and Endocrinology, Flinders Medical Centre, Adelaide, SAProfessor M Korbelik British Columbia Cancer Agency, Vancouver, BC, CanadaDr L Wang Medical School, Monash University, Melbourne, VIC
Dr WB CowdenThe role of nitric oxide in infectious and autoimmune diseaseDr K Rockett Institute of Molecular Medicine, University of Oxford, Oxford, UKThe role of NO in regulation of EAEDr D Willenborg Neurosciences Research Unit, The Canberra Hospital, Canberra, ACTThe activity and mechanism of action of novel glycoprotein processing inhibitor anti-rejection agentsProfessor A Hibberd Hunter Valley Hospital Transplant Unit, Newcastle, NSW
Professor AF DulhuntyVarious aspects of ryanodine receptor physiologyDr D Laver Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSWIdentification of novel RyR specific compoundsProfessor DG Lamb Department of Zoology, La Trobe University, Melbourne, VIC
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Collaborations 2006
Research Collaborations
Role of triadin and calsequestrin in regulating calcium release from intracellular stores and Contribution of splicing defects in ryanodine receptors to myotonic dystrophyProfessor R Dirksen Department of Pharmacology and Physiology, University of Rochester Medical Centre, Rochester, NY, USARegulatory and pore forming domains of calcium release channelsProfessor F Zorzato Department of Experimental and Diagnostic Medicine, General Pathology Section, University of Ferrara Medical School, Ferrara, ItalyActions of CLIC and GST family proteins on the heartDr M Diaz School of Veterinary Studies, The University of Edinburgh, Edinburgh, UKRole of the Beta subunit of the dihydropyridine receptor in excitation-contraction couplingProfessor J Abramson Department of Physics, Portland State University, Portland, OR, USAContribution of splicing defects to myotonic dystrophyProfessor M Takahashi Department of Neurology, Osaka University Graduate School of Medicine, Osaka, JapanStudies of the molecular nature of calsequestrinProfessor M Varsanyi Institut für Physiologische Chemie, Ruhr Universität, Bochum, GermanyStructure of ion channel domain peptidesProfessor N Ikemoto Boston Biomedical Research Institute, Boston, MA, USARegulation of ion channels by CRISP proteinsDr M O’Brien and Dr G Gibbs Monash Institute of Medical Research, Melbourne, VIC
Professor S EastealGenetic epidemiology of high prevalence mental disordersProfessor A Jorm ORYGEN Research Centre, The University of Melbourne, Melbourne, VICGenetic epidemiology of neuroanatomical correlates of high prevalence mental disordersProfessor P Sachdev School of Psychiatry, The University of New South Wales, Sydney, NSWIdentifying genes that modify athletic performanceProfessor K North Neurogenetics Research Unit, The Children’s Hospital at Westmead, Sydney, NSW
Dr C FreemanRoles of VEGF and heparanase in diabetic retinopathy and the use of HS-mimetics to inhibit their actionsDr J Hu Zhongshan University, Guangzhou, China
Design of novel HS-mimetics to inhibit uptake, replication and cell-to-cell spread of HSV, HIV and RSVDr E Trybala Department of Clinical Virology, Goteborg University, Goteborg, SwedenExpression of heparanase in ischemic lesions of rat brainProfessor H Takahashi Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime, JapanIdentification of patients lacking heparanase activityDr H Yang Jiangsu Institute of Hematology, The First Affliated Hospital of Soochow University, Suzhou, ChinaInhibition of Plasmodium falciparum growth and cell adhesion by heparan sulfate mimeticsDr K Andrews Queensland Institute of Medical Research and Australian Centre for International and Tropical Health and Nutrition, Brisbane, QLDUse of HS-mimetics for Alzheimer’s diseaseProfessor D Small and Dr M Beckman Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VICNovel HS-mimetics that inhibit smooth muscle cell proliferationProfessor L Khachigian and Dr F Santiago Centre for Vascular Research, Department of Pathology, The University of New South Wales, Sydney, NSWInhibition of C1s protease activity of the classical complement pathwayAssociate Professor R Pike Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VICThe role of heparanase in rheumatoid arthritisDr R Li and Dr P Smith The Canberra Hospital, Canberra, ACT
Dr C Freeman and Dr L SimsonUse of novel HS-mimetics to mobilise haemopoietic progenator and stem cells into the circulationProfessor J-P Levesque Haematopoietic Stem Cell Laboratory, Cancer Biotherapies Program, Mater Medical Research Institute, Brisbane, QLD
Professor C GoodnowMechanisms regulating islet beta cells in diabetesDr C Nolan The Canberra Hospital, Canberra, ACTMucin gene functionsDr M McGuckin Mater Medical Research Institute, Brisbane, QLDDr M Cook Phenomix Aust Pty Ltd, Canberra, ACT
Professor Levon Khachigian, Centre for Vascular Research, Department of Pathology, The University of New South Wales
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Research Collaborations
Professor C Goodnow and Dr E BertramMutations affecting male fertilityDr M O’Bryan and Professor D de Kretser Monash Institute of Reproduction and Research, Melbourne, VICMutations affecting the mammary glandDr C Ormandy The Garvan Institute of Medical Research, Sydney, NSW
Professor C Goodnow, Dr E Bertram, Dr C Vinuesa and Dr L TzeIdentifying genes for immunity and toleranceDr J Cyster, Professor L Lanier and Professor A Weiss University of California, San Francisco, CA, USA
Professor C Goodnow, Dr E Bertram and B WhittleHearing mutationsDr H Dahl Murdoch Children’s Research Institute, Melbourne, VIC
Professor C Goodnow and Dr G HoyneRole of cbl genes in B and T cell toleranceAssociate Professor W Langdon and Dr C Thien The University of Western Australia, Perth, WA
Professor C Goodnow and Dr A ListonThymic defects in aire-deficiencyProfessor R Boyd and D Gray Monash University, Melbourne, VICEffects of Foxp3 deficiency on islet-specific toleranceProfessor A Rudensky Department of Immunology, University of Washington, Seattle, WA, USA
Professor C Goodnow and Dr C VinuesaA programme of screening for ENU-mutations affecting lymphocyte response to antigenDr R Cornall and Professor J Bell University of Oxford, Oxford, UK
Professor JE GreadyComputational studies of disulfide bridges in proteinsDr M Wouters Victor Chang Cardiac Research Institute, Sydney, NSW
Professor JE Gready, Mr H Alonso and Dr PL CumminsComputational simulation of the mechanism of the enzyme methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr)Professor S Ragsdale University of Nebraska, Lincoln, NB, USA
Professor JE Gready and Mr N ChakkaAssessment of gene dysfunction in human male infertilityDr M O’Bryan Monash Institute of Reproduction and Research, Melbourne, VIC
Professor JE Gready, Mr N Chakka and Ms T VassilievaEvolution of prion protein and its homologues in vertebratesDr T Simonic and Dr L Sangiorgio Department of Animal Pathology, University of Milan, Milan, ItalyProfessor SV Edwards and Dr D Janes Department of Organismic and Evolutionary Biology and Museum of Comparative Zoology, Harvard University, Cambridge, MA, USA
Professor JE Gready, Dr PL Cummins and Dr IV RostovApplication of the ONIOM QM/MM method to simulation of enzyme reactionsDr T Vrevren and Dr MJ Frisch GAUSSIAN Inc, New Haven, CT, USA
Professor JE Gready and Ms T VassilievaRegulation of prion protein and doppel by FAC1Professor K Jordan-Sciutto Penn State University, Philadelphia, PA, USA
Professor IA HendryTesting behaviour of Gz knockout mice using pre-pulse inhibitionDr M van den Buuse Mental Health Research Institute of Victoria, Melbourne, VICPupillary constriction in Gz knockout miceProfessor KW Yau Johns Hopkins University School of Medicine, Baltimore, MD, USAGz coupling to dopamine D2-like receptors in vivoDr CD Blaha Macquarie University, Sydney, NSWNeuromuscular growth factors role of TGF-beta and GDNF in motoneurone survival and deathDr I McLennan University of Otago, Dunedin, NZ Increase of IGFBP1 following hypoxia in the piglet. Protein 14-3-3 in the CSF of newborn rats following hypoxia-ischaemiaDr Z Kecskes The Canberra Hospital, Canberra, ACTHypoxia alters GABAA-subunit compositionDr P Dodd School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLD
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Collaborations 2006
Research Collaborations
Professor CE HillIdentification of IP3 receptor subtypes in arteries and astrocytes Dr RJH Wojcikiewicz Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USAModelling of vasomotion in cerebral arteriesProfessor T Griffith and Dr D Parthemos University of Cardiff, Cardiff, UKRole of T-type calcium channels in control of cerebrovascular tone Dr LL Cribbs Cardiovascular Institute, Loyola University Medical Center, Loyola, IL, USARole of eNOS in connexin expression in renal microvasculature and induction of diabetes Professor S Kawashima and M Yokoyama The First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan Professor PL Huang Harvard Medical School, Cardiovascular Research Centre, Massachusetts General Hospital, Charlestown, MA, USARole of gap junctions in renal autoregulation and blood pressureDr T Takenaka and Professor H Suzuki Department of Nephrology, Saitama Medical College, Saitama, JapanRole of the endothelium and gap junctions in cerebral vasomotion Dr RE Haddock and Dr SL Sandow Department of Physiology and Pharmacology, The University of New South Wales, Sydney, NSW
Professor GDS HirstProperties of interstitial cells of Cajal in the gastrointestinal tractProfessor H Suzuki and Dr H Hashitani Department of Physiology, Nagoya City University Medical School, Nagoya, JapanProperties of ion selective channels in gastric smooth muscle cellsDr N Teramoto Kyushu University, Fukuoka, Japan
Dr G HoyneDelta3-Notch signalling in T cell development and functionDr S Dunwoodie and Dr G Chapman The Victor Chang Cardiac Research Institute, Sydney, NSWEffects of Lunatic Fringe a modulator of Notch signalling in T cell development and toleranceDr C Guidos University of Toronto, Toronto, Canada
A novel immunotheraphy for type 1 diabetes based on targeting of the Notch signalling pathway in autoantigen-specific cellsDr B Champion Celldex Therapeutics Limited, Cambridge, UK
Dr G Hoyne and Dr E BertramRole of CD45 splicing and susceptibility to autoimmune disease in miceDr D Willenborg The Canberra Hospital, Canberra, ACT
Dr G Hoyne and Professor MF ShannonRole of c-rel in regulatory T cell differentiation and homeostasisProfessor S Gerondakis The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC
Dr M HulettRole of EGR1 and YY1 in tumour progressionProfessor LM Khachigian The University of New South Wales, Sydney, NSWGeneration of heparanase and HRG knockout miceDr R Brink Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSWHeparanase expression in EAEAssociate Professor D Willenborg and Dr M Staykova The Canberra Hospital, Canberra, ACTHeparanase expression in hypoxiaProfessor M Whitelaw and D Peet The University of Adelaide, Adelaide, SADr B Roberts The University of South Australia, Adelaide, SACharacterisation of the interaction of histidine-rich glycoprotein with leukocyte Fc receptorsProfessor M Hogarth and Dr B Wines Austin Research Institute, Melbourne, VICMigration of eosinophils in inflammatory diseaseDr S Hogan Cincinnati Children’s Hospital Medical Centre, Cincinnati, OH, USA
Dr G HuttleyEvolution of triplet-repeat containing proteinsMr N Faux and Professor J Whisstock Monash University, Melbourne, VICBRCA1 evolution in mammalsDr M Wakefield The Walter and Eliza Hall Institute of Medical Research, Melbourne, VICEvolution of mammalsDr M Wakefield The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC
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Research Collaborations
Analytical tools for comparative genomics Professor R Knight Colorado State University, Boulder, CO, USA Dr M Wakefield The Walter and Eliza Hall Institute of Medical Research, Melbourne, VICAlignment of biological sequencesMr A Isaev Cray Pty Ltd, Canberrra, ACT
Dr T JuelichElucidation of transcriptional mechanisms for the establishment and maintenance of CD8 T cell effector gene function in a mouse influenza A modelDr S Turner The University of Melbourne, Melbourne, VIC
Dr G Karupiah and Dr G ChaudhriPathophysiological significance of reverse signalling through membrane TNFDr J Sedgwick Bone and Inflammation Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USAModulation of the immune response by poxvirusencoded cytokine homologsProfessor M Buller Department of Molecular Microbiology and Immunology, St Louis University, St Louis, MO, USADr A Alcami Department of Molecular and Cellular Biology, Centro Nacional De Biotecnologia, Madrid, SpainMapping of orthopoxvirus CD8 T cell determinantsDr D Tscharke Queensland Institute for Medical Research, CBCRC, Brisbane, QLDDr J Yewdell and Dr J Bennink National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAChemokine receptors in infectious diseasesDr W Kuziel Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USAProfessor M Mack Klinikum der Universität Regensburg, Innere Medizin II, Abt für Nephrologie, Regensburg, GermanyPathogenesis of influenza pneumonia and flavivirus encephalitisDr A Scalzo The Lions Eye Institute, Perth, WA Dr W Yokoyama Washington University School of Medicine, St Louis, MO, USAInvestigating the role of dendritic cell subsets in anti-poxviral immunityDr G Belz The Walter and Eliza Hall Institute for Medical Research, Melbourne, VIC
Tracking virus-specific B cells using Blimp-1 transgenic miceDr S Nutt The Walter and Eliza Hall Institute for Medical Research, Melbourne, VIC
Professor TD LambTransduction and adaptation in photoreceptorsProfessor EN Pugh Jr Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USAPhototransduction in conesDr S Kawamura Graduate School of Frontier Bioscience, Osaka University, Osaka, Japan,Dr Y Fukada Department of Biophysics and Biochemistry, Graduate School of Science, JapanHuman electroretinogramDr OAR Mahroo Physiological Laboratory, University of Cambridge, Cambridge, UKMolecular mechanisms of vertebrate phototransductionDr RD Hamer Smith-Kettlewell Eye Research Institute, San Francisco, CA, USADevelopment of a scanning laser ophthalmoscopeDr FN Reinholz and Dr BA Patterson Lions Eye Institute, Perth, WAResponses of human cone photoreceptorsDr H van Hateren Department of Neurobiophysics, University of Groningen, Groningen, The Netherlands
Dr M LobigsFlavivirus virulence and vaccinationDr RA Hall Department of Microbiology and Parasitology, The University of Queensland, Brisbane, QLDFlavivirus interferon escapeDr A Khromykh School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLDDengue virus virulence, pathogenesis and tropisDr PJ Wright Department of Microbiology, Monash University, Melbourne, VIC Dr A Davidson University of Bristol, Bristol, UKCytomegalovirus US6 glycoprotein interactions with TAPDr H Hengel Institute for Virology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, GermanyCross-protective value of Chimerivax-JEV against Australian flavivirusesProfessor T Monath ACAMBIS INC, Cambridge, MA, USA
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Collaborations 2006
Research Collaborations
Dr M Lobigs and Dr P CooperFlavivirus vaccines based on inulin adjuvantsProfessor N Petrovsky Flinders Medical Centre, Adelaide, SA
Dr KI MatthaeiThe role of IL-5 and eosinophils in gut allergyDr S Hogan Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USAThe role of IL-5 and eosinophils in allergyDr M Rothenberg Division of Pulmonary Medicine, Allergy & Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USAThe role of “Flightless I” in wound healingDr A Cowin Skin Biology Laboratory, Child Health Research Institute, Adelaide, SAParasite infection in gene deficient miceDr L Dent Eosinophil Biology Laboratory, Microbiology and Immunology, School of Molecular and Biomedical Science, Adelaide University, Adelaide, SAThe role of the ryanodine receptor in vivoProfessor P Allen Department of Anesthesia, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA
Professor A MüllbacherOral induced T cell toleranceDr J Chin Elizabeth MacArthur AG Institute, NSW Department of Agriculture, Camden, NSWThe role of granzyme A in fungal infectionDr R Ashman Oral Biology and Pathology, The University of Queensland, Brisbane, QLDThe role of granzymes in viral infectionProfessor M Smyth Peter MacCallum Cancer Centre, Melbourne, VICGliotoxin as virulence factor in AspergillosisDr J Pardo and Dr M Simon Max Planck Institute fur Immunbiologie, Freiburg, Germany
Professor A Müllbacher and Dr M RegnerThe granzymes in early defence against viral infectionDr J Trapani and Dr V Sutton Peter MacCallum Cancer Centre, Melbourne, VICRole of granzymes in cytolytic leukocyte-mediated killing and viral-induced immunopathologyDr M Simonand Dr J PardoMaxPlanckInstitutefurImmunbiologie,Freiburg-Zahringen,Germany
The role of poxvirus encoded serpins in cytotoxic T cell induced apoptosisDr R Wallich Department of Immunology, University of Heidelberg, Heidelberg, GermanyGamma irradiated influenza virus as a vaccine against bird fluDr D Boyle and Dr T Bowden CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, VIC
Professor C ParishRole of platelets in tumour metastasisDr M Berndt The Baker Medical Research Institute, Melbourne, VICProfessor C Chesterman and Professor B Chong School of Pathology, The University of New South Wales, Sydney, NSWCarbohydrate-based inhibitors of leukocyte extravasationDr M Hickey Department of Medicine, Monash University, Melbourne, VICDevelopment of dendritic cell targeting vaccinesAssociate Professor D Jackson Department of Microbiology and Immunology, The University of Melbourne, Melbourne, VICDevelopment of a liposome-based TB vaccineDr W Britton Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW
Professor C Parish and Dr L SimsonDevelopment of a liposome-based tumor vaccineAssociate Professor P Hogg School of Pathology, The University of New South Wales, Sydney, NSWImmunosurveillance of MCA-induced sarcomas in TH2-immune deficient miceProfessor M Smyth Peter MacCallum Cancer Centre, Melbourne, VIC
Professor IA RamshawEvaluation of HIV prophylactic and therapeutic vaccinesDr S Kent The University of Melbourne, Melbourne, VICDesign of HIV-1 vaccinesDr D Boyle CSIRO Australian Animal Health Laboratory, Geelong, VICDevelopment of vaccines against genetically modified virusesProfessor A Ramsay Louisiana State University Health Sciences Center, New Orleans, LA, USA
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Development of a novel TB vaccineDr W Britton Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSWEvaluation of a nasopharyngeal cancer therapeutic vaccineProfessor D Moss Queensland Institute of Medical Research, Brisbane, QLDDevelopment of enhanced immune responses to HIV vaccinesProfessor P Doherty and Dr S Turner The University of Melbourne, Melbourne, VIC
Dr C RanasingheHIV pox-virus vaccines and CD8 T cell avidityDr S Turner The University of Melbourne, Melbourne, VICMucosal vaccines and immunityProfessor A Ramsay Louisiana State University Health Sciences Center, New Orleans, LA, USA
Dr S RaoMicroarray functional analysisDr G Denyer The University of Sydney, Sydney, NSWComputational promoter analysisDr T Werner Genomatix, Munich, GermanyHIV and RNAi strategiesAssociate Professor A Kelleher National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, NSW Regulatory T-cells and transcriptional regulationDr N Seddiki Centre for Immunology, Sydney, NSWEffector function gene analysisDr S Turner The University of Melbourne, Melbourne, VIC
Dr C RaymondThe persistence of spike timing-dependent plasticityProfessor WC Abraham Department of Psychology, University of Otago, Dunedin, NZ
Professor SJ RedmanThreshold excitation in dendritic neuronsProfessor J Jack University College, London, UKRadial redistribution of calcium in pyramidal cell somas and regulation of slow after-hyperpolarisationDr W Spain University of Washington, Seattle, WA, USADr R Foehring University of Tennessee, Memphis, TN, USAElectrotonic coupling and rythmogenesis in the spinal cordProfessor R Brownstone Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
Professor MF ShannonControl of GM-CSF gene transcription in T cellsDr A Holloway Discipline of Biochemistry, University of Tasmania, Hobart, TASThe role of c-Rel in CD28 signaling and regulatory networks in T cellsDr S Gerondakis The Walter and Eliza Hall Institute of Medical Research, Melbourne, VICIL-2 gene regulation in T cells Professor R Schwartz Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD, USATranscriptional networks in T cellsDr K Gardener National Cancer Institute, National Institutes of Health, Bethesda, MD, USAThe role of Foxp3 in regulatory T cellsDr S Barry Department of Paediatrics, The University of Adelaide, Adelaide, SAMicro RNAs and control of transcriptionDr Greg Goodall Hanson Institute, Adelaide, SA
Dr CJ Simeonovic Transient transmission of porcine endogenous retrovirus (PERV) to fetal lambs after pig islet tissue xenotransplantation Dr RR Tönjes Division of Medical Biotechnology, Paul-Ehrlich-Institute, Langen, GermanyClinical Associate Professor JD Wilson Department of Endocrinology, The Canberra Hospital, Canberra, ACTDr P McCullagh Faculty of Veterinary Science, The University of Sydney, Sydney, NSWRole of matrix metalloproteinases in the development of destructive autoimmunity and clinical diabetes in NOD miceDr R Rodgers Department of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, SA
Dr L SimsonEosinophils in respiratory syncytial virus InfectionAssociate Professor S Mahalingam Centre for Virus Research, University of Canberra, Canberra, ACT
Associate Professor C StrickerQuantal analysis of cell pairs in the subplate during developmentDr J Torres and Professor MJ Friedlander Department of Neurobiology, University of Alabama, Birmingham, AL, USA
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Research Collaborations
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Collaborations 2006
Research Collaborations
Dr GJ StuartInteraction of action potentials with inhibitory synaptic eventsProfessor M Häusser Wolfson Institute for Biomedical Research, University College, London, UKRole of HCN Channels in absence epilepsyDr S Petrou, Professor S Berkovic and Associate Professor T O’Brien The University of Melbourne, Melbourne, VICDr L Dibbins Women’s and Children’s Hospital, Adelaide, SACharacterisation of synaptic plasticity following motor learning in the ratDr T Aumann The University of Melbourne, Melbourne, VIC
Dr ML TierneyEffects of mutations in M2 on the conductance of GABAA receptors.Dr B Cromer St Vincent’s Institute of Medical Research, Melbourne, VICA universal approach towards the design, expression and characterisation of soluble ligand binding domains of ligand-gated ion channelsDr N Unwin Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
Dr DJ TremethickThe role of histone variants in modulating chromatin fibre dynamicsDr K Luger Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USAThe structure and function of histone variants during spermatogenesisDr C Caron Institut Albert Bonniot, Grenoble, FranceImprinted X inactivation in MammalsDr J Lee Massachusetts General Hospital, Boston, MA, USAChromatin remodelling during X inactivationDr E Heard Curie Institute, Paris, France
Dr CG VinuesaRole of SAP in follicular helper T cell (TFH) differentiationDr J Cannons and P Schwartzberg National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USARegulation of ICOS expression by RoquinDr KP Lam Laboratory of Molecular and Cellular Immunology, Biomedical Sciences Institute, Agency for Science, Technology and Research, (A*STAR), Singapore
Memory formation in germinal centresProfessor I MacLennan MRC Centre for Immune Regulation, The University of Birmingham, Birmingham, UKIdentification of ROQUIN allelic variants in patients with familial SLEDr J Harley Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, USARole of ICOS in systemic and organ-specific autoimmunityDr A Hutloff Robert Koch Institute, Berlin, Germany
Dr CG Vinuesa and Dr M CookAPOSLE study- Identification of susceptibility alleles in Australian SLE patientsDr S Addlestein Royal Prince Alfred Hospital, Sydney, NSWDr S Riminton Repatriation General Hospital, Sydney, NSWDr D Fulcher Westmead Hospital, Sydney, NSWDr S Alexander Children’s Hospital, Sydney, NSWDr P Pavli The Canberra Hospital, Canberra, ACT
Professor B WalmsleyElectrical stimulation of the cochlea in congenitally deaf miceProfessor R Shepherd Bionic Ear Institute, Melbourne, VICMechanisms of central neuronal integrationProfessor REW Fyffe Center for Brain Research, Wright State University, Dayton, OH, USAMembrane properties of auditory neuronsProfessor ID Forsythe The University of Leicester, Leicester, UKIn vivo recordings of auditory neurons in congenitally deaf miceDr AG Paolini La Trobe University, Melbourne, VIC
Dr HS WarrenNatural Killer cell subsets in cord bloodDr D Knight Department of Obstetrics and Gynaecology, The Canberra Hospital, Canberra, ACT
Dr DC WebbComparative roles of IL-4 and IL-13 in regulating dendritic cell function Professor P Foster Discipline of Immunology and Microbiology, The University of Newcastle, Newcastle, NSW
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The development of allergic inflammation in the lungs of GSTP-/- miceProfessor R Wolf and Dr C Henderson Ninewells Hospital and Medical School, Dundee, UKExpression of the Ym2 protein in a chronic murine model of allergic pulmonary diseaseAssociate Professor R Kumar Department of Pathology, The University of New South Wales, Sydney, NSWIdentification of Ym-homologous human proteins and their relationship to disease severity in asthmaticsProfessor F Chung Imperial College London, London, UKCiliated cell specific expression of GSTPDr L Ostrowski University of North Carolina, Chapel Hill, NC, USA
Professor JA Whitworth and Dr Y ZhangGlucocorticoid receptors in knockout miceDr TJ Cole Department of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VICMechanism(s) by which glucocorticoids induce hypertension in humansDr J Kelly and Dr G Mangos St George Hospital, Sydney, NSWEffects of antioxidants and glucocorticoids on plasma F2-isoprostane concentrationsAssociate Professor K Croft and Dr T Mori School of Medicine and Pharmacology, Royal Perth Hospital Unit, The University of Western Australia, Perth, WA
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Research Collaborations
Optimising microarray in experimental hypertensionProfessor W Anderson Department of Physiology, School of Biochemical Sciences, Monash University, Melbourne, VICPlamsa BH4 analysisDr J Earl Department of Clinical Biochemistry, The Children’s Hospital at Westmead, Sydney, NSWGene expression in glucocorticoid induced hypertension in ratsDr R Lin School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW
Professor IG YoungRole of IL-3 receptor in myeloid leukaemia Dr K F Bradstock Department of Haematology, Westmead Hospital, Sydney, NSWProfessor Y Chen Fujian Medical University, Fuzhou, ChinaSubcellular targeting of photosensitizers and other locally acting drugs with application in cancer therapyDr AS Sobolev Department of Biophysics, Moscow State University, Moscow, Russia
Professor Sam Berkovic The University of Melbourne
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Visitors 2006
Visitors to JCSMR 2006We have welcomed colleagues from Australia and overseas into The John Curtin School of Medical Research throughout 2006, to share their research findings or to carry out research projects in JCSMR laboratories in collaboration with JCSMR staff and students.
Professor WC AbrahamDepartment of Psychology, University of Otago, Dunedin, New Zealand
Professor P BartlettQueensland Brain Institute, The University of Queensland, Brisbane, QLD
Professor T BlankensteinMax-Delbrueck Center for Molecular Medicine and Institute of Immunology of the Charite, Berlin, Germany
Professor D BowtellPeter MacCallum Cancer Centre, Melbourne, VIC
Professor G Chevenix-TrenchQueensland Institute of Medical Research, Brisbane, QLD
Dr A de MestreBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Professor J EliasYale University School of Medicine, New Haven, CT, USA
Dr C EngwerdaImmunology and Infection Laboratory, Queensland Institute of Medical Research, Brisbane, QLD
Professor B Fazekas de St GrothCentenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW
Professor M FeldmannImperial College, London, UK
Dr C FineCentre for Applied Philosophy and Public Ethics, The University of Melbourne, Melbourne, VIC
Dr E FinkelCosmos, Melbourne, VIC
Dr R FoehringUniversity of Tennessee, Memphis, TN, USA
Professor B FrenchDepartment of Physiology & Biophysics, The University of Calgary, Calgary, Alberta, Canada
Dr M FreseVirus Research Group, Biomedical Sciences; Health, Design and Science, The University of Canberra, Canberra, ACT
Professor J HarleyRheumatology, Immunology & Allergy Division, University of Oklahoma Health Sciences Center, OK, USA
Dr K HeinzelMax-Planck-Institute for Immunobiology, Freiburg, Germany
Mr J HendersonCray Australia, Pty Ltd, Canberra, ACT
Dr P HodgkinImmunology Division, The Walter and Eliza Hall Institute of Medical Reserarch, Melbourne, VIC
Professor M HogarthBurnet Institute, Melbourne, VIC
Professor D JansDepartment of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC
Dr L JermiinThe University of Sydney, Sydney, NSW
Professor L KhachigianCentre for Vascular Research, The University of New South Wales, Sydney, NSW
Professor P KoopmanInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD
Professor KP LamSigN - Singapore Immunology Network, Agency for Science Technology and Research (A*Star), Biopolis, Singapore
Dr S LesageHospital Masisonneuve-Rosemont, Centre de Recherche Guy-Bernier, Montreal, Quebec, Canada
Professor G MannWestmead Millennium Institute for Medical Research, Sydney, NSW
Dr A MansellCentre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Melbourne, VIC
Dr M McConvilleThe Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, VIC
Professor David Bowtell, Peter MacCallum Cancer Centre, Melbourne.
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Professor G McFaddenBotany School, The University of Melbourne, Melbourne, VIC
Professor R MoqbelUniversity of Alberta, Edmonton, AB, Canada
Mr B BuckleyEssys Pty Ltd, Canberra, ACT
Dr C NorburyDepartment of Microbiology and Immunology, Hershey Medical Center, Penn State University, Hershey, PA, USA
Dr R OlsenMolecular & Medical Pharmacology, UCLA, Los Angeles, CA, USA
Dr P PapathanasiouStanford University School of Medicine, Stanford, CA, USA
Dr W PattersonThe University of Western Australia, Perth, WA
Dr W PaulNational Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Dr F ReinholzLions Eye Institute, Perth, WA
Associate Professor M RyanDepartment of Biochemistry, La Trobe University, Melbourne, VIC
Dr A ScalzoDepartment of Microbiology, University of Western Australia, Perth, WA
Dr M SelgelidCentre for Value, Ethics and the Law in Medicine, University of Sydney, Sydney, NSW
Dr W SpainUniversity of Washington, Seattle, WA, USA
Professor T SpeedThe Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC
Professor J SprentGarvan Institute of Medical Research, Sydney, NSW
Professor R StockerFaculty of Medicine, The University of Sydney, Sydney, NSW
Dr H TangCentre for Infection and Immunity, The Institute of Biophysics, Chinese Academy of Sciences
Professor E WhitelawQueensland Institute of Medical Research, Brisbane, QLD
Dr R WilliamsSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW
Dr J WilsonEditor, Nature Immunology, New York, NY, USA
Dr S WoodStem Cell Laboratory, Child Health Research Institute, Adelaide, SA
Mr R WylieApple Computer Australia Pty Ltd
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6
Visitors
Dr Cordelia Fine, Centre for Applied Philosophy and Public Ethics, The University of Melbourne.
Staff, Students & Invited Presentations
Thefollowingsectionprovidesadirectoryofstaffandstudents
ofTheJohnCurtinSchoolofMedicalResearchduring2006,
undertheirDivisionalgroupings.
Includedisalistofscientificpresentationsourstaffand
studentshavebeeninvitedtopresentatconferencesandat
otherresearchinstitutionsbothnationallyandinternationally
throughouttheyear.
The John Curtin School of Medical Research Annual Review 2006
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Staff 2006
Division of Immunology & Genetics
Professor and HeadParishCR,BAgrSc(UMelb),PhD(UMelb)
School Technical Support OfficersWoltringD,AssDipBiol(CIT),AssDipPath(CIT),BSc(fromApril)WoodhamsCE,BAppSc(CCAE),GradDipInfSyst(UC)(untilAugust)
Divisional AdministratorWeilETF
Cancer and Human Immunology Group Fellow and LeaderWarrenHS,BSc(Hons),PhD(Qld),NHMRCSeniorResearchFellow
Research FellowBettadapuraJ,MSc,PhD(Bangalore)(untilMay)
Senior Technical OfficerJacksonRJ,BSc(Hons)(Monash),PhD(Edin)(fromJuly)(part-time)
Cancer and Vascular Biology Group Professor and LeaderParishCR,BAgrSc(UMelb),PhD(UMelb)
FellowFreemanC,BSc(Hons)(Adel),PhD(Adel)
Viertel Senior Medical Research FellowHulettM,BSc(Hons)(UMelb),PhD(UMelb)(transferred to Division of Molecular Biosciences from July)
Research FellowsHindmarshEJ,BSc(Hons)(USyd),PhDRaoS,BSc(Hons)(Keele),PhD(KingsCollegeLond)
NHMRC Peter Doherty Postdoctoral FellowsQuahB,BSc,PhDSimsonL,BSc(UC),PhD
Postdoctoral FellowEichnerD,BSc(Hons)(transferred to Division of Molecular Biosciences from July)
Visiting FellowsAbdul-MajidAMS,PhD(UNSW)(September-October)AdaGL,DSc(USyd),FAAAltinJ,BSc,GradDipSci,PhDBurchWM,BSc(UMelb),MSc(UMelb),PhD(Lond)ChestermanC,MBBS(USyd),DPhil(Oxon),FRACP,FRCPACooperPD,DSc,PhD(ULond)(untilMay)FangY-Y,BMed(ShanghaiSecondMedicalUniversity),PhD(Adel)LiR,MD(ChinaMedicalUniversity),PhD(SouthernCross)(fromApril)
MimsC,BSc,MD(ULond)PriceJ,BSc(Hons)(UMelb),PhD(UMelb)(fromDecember)StaykovaM,PhD(USofia)
School AssociateNOzarac,BSc(UNSW),PhD(UNSW)
Senior Technical OfficersBezosA,BSc(USyd),MSc(USyd)HornbyJ,BSc(Hons)(Queens,Belfast)(transferred to Division of Molecular Biosciences from July)
Technical OfficersBrowneA,BAPaglerE,BSc(SantoTomas)(transferred to Division of Molecular Biosciences from July)
Technical Officer Vavrina-KunA,BMedSci(part-time)
Visiting Technical OfficersGomersallT,BAppSc(UC)(untilJuly)WaringS,BSc(Hons)(UNSW)(August-December)
Laboratory Technician JianP(part-time)
Editorial/Administrative Assistant ParishB,BSc(Madras),BSc,MSc,GradDipCompStudies(UC)(part-time)
Cellular Microbiology Group (from September)Professor and LeaderHirstT,BSc(Hons)(Kent),DPhil(York)
Computational Genomics Laboratory (transferred to Division of Molecular Bioscience from July)
Diabetes/Transplantation Immunobiology Laboratory Fellow and Leader SimeonovicCJ,BSc(Hons),PhD
Visiting Fellows McCullaghP,MBBS(UMelb),DPhil(Oxon),MRCP(Lond),MD(UMelb)WilsonJD,BSc(Hons),MBBCh,BAO(Hons),MD(Queens,Belfast),MRCP(UK),FRACP
Technical OfficersBrownD,AsDipAppPath(CIT)(part-time)HamiltonP,CertificateIIinAnimalTechnology(CIT)PoppSK,BSc,AssDipAppSci,Biol(CIT)
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Staff 2006
Division of Immunology & Genetics
The Immunogenomics Laboratory Professor and Laboratory HeadGoodnowCC,BVSc(Hons)(USyd),BScVet(Hons)(USyd),PhD(USyd),FAA
Executive Assistant to Professor GoodnowVitlerL
Laboratory ManagerTownsendM,PathTechCert(TAFE),AssDipAppPath(TAFE)
Immune Tolerance and Signalling Genomics GroupProfessor and LeaderGoodnowCC,BVSc(Hons)(USyd),BScVet(Hons)(USyd),PhD(USyd),FAA
Research FellowBertramE,BSc(Hons)(Adel),PhD(Adel)
Postdoctoral FellowsDaleyS,BVSc(UQ),DPhil(Oxon)(fromMay)HorikawaK,MD(Chiba),PhD(Tokyo)ListonA,BSc(Hons)(Adel),PhD(untilFebruary)ManaP,PharmD,MPharm,PhD(SantiagodeCompostela)
DFG, German Research Foundation PD FellowEndersA,MD(Freiburg)
NHMRC Peter Doherty Postdoctoral FellowTzeL,BSc(Beloit),PhD(Minnesota)
Visiting FellowsAthanasopoulosV,PhD(UMelb)CornallR,PhDFahrerA,BSc(Hons)(UMelb),PhD(UMelb)JenneC,BSc(Hons)(Guelph),PhD(Calgary)(fromFebruary)WatsonS,BSc(Hons)(Edin),PhD(ULond)(February-March)
Laboratory Technical Staff
In charge of pre-immune serologyDomaschenzH,PathTechCert(TAFE)
In charge of immune serologyKucharskaE,BSc,MSc(Warsaw)
Research TechniciansEmmettS,BSc(Hons)(Monash)HowardD,BScPulsfordK,DipAppSci(CIT)RootsC,BAppSci(UC)SjollemaG,BSc(Hons)WilsonJ,AssocDipAnimalSci(CIT)(March–December)
Research Assistants SiggsOM,BSc(Adel),DipLang(Adel)(January-June)WilsonA,BSc(Hons)(UC),RN(part-time)
Laboratory AssistantsHoyneR(casual)HuX,BSc(BeijingInstituteofTechnology)
Humoral Immunity and Autoimmunity GroupSenior Research Fellow and Program LeaderVinuesaCG,LMS(MBBS)(Madrid),DRCOG(ULond),MSc,PhD(Birmingham)
Postdoctoral FellowsAthanasopoulos,Vicki(part-time)(untilJune)RigbyR,BSc(SheffieldHallam),PhD(ImperialCollegeLond)(fromSeptember)SilvaD,MBBS(Colombia),PhD
Visiting FellowWalterG,BA(Cantab),MBChB(Edin),MRCP(UK),MD(fromSeptember)
Laboratory Technical StaffAngelucciC,BSc(Hons)(Deakin),PhDHoganJ,BMedSci,GradDipGenCouns(Newcastle)
Laboratory AssistantHuX,BSc(BeijingInstituteofTechnology)
Research Assistant WilsonA,BSc(Hons)(UC),RN(part-time)
T Cell Development and Regulation Genomics GroupSenior Research Fellow and Program Leader HoyneG,BSc(Hons)(UWA),PhD(UWA)
Laboratory Technical StaffKofflerJ,BAppSc(UC)
Immunopathology Group Fellow and LeaderCowdenWB,BS(TroyState),PhD(UQ)(untilNovember)
Visiting Fellows EschlerB,BSc(Hons)(USyd),DipEd(USyd),MSc(USyd),PhD(Woll)(untilDecember)MarchD,BSc(Hons)(Adel),PhD(UQ)(untilDecember)
Technical OfficersBartellG,BSc(Hons)(USyd),MSc(untilAugust)GapellaJP,AnimalTechCert(TAFE)(untilDecember)
Laboratory TechnicianHigginsD,DipApplSci(CIT)(untilSeptember)
Visiting Technical OfficersMartinL,BSc(Newcastle)(untilDecember)PavlinovicL(untilMarch)
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Division of Immunology & Genetics
Infection and Immunity Group Senior Research Fellow and LeaderKarupiahG,BSc(Hons),MSc(Malaya),PhDInternationalResearchScholaroftheHowardHughesMedicalInstitute
Research FellowChaudhriG,BSc(Hons),PhD
CJ Martin FellowWangY,MB(BeijingMedical),MM(USyd),PhD
Postdoctoral FellowPanchanathanV,MBBS,MPhil(Malaya)
Visiting FellowsBelzG,BVBiol(UQ),BVSc(Hons)(UQ),PhD(UQ)FoxwellR,BSc(UWA),BSc(Hons)(UMelb),MSc(Lond),PhD(UC),GradCertHigherEducation(UC)ScalzoA,BSc(Hons)(UMelb),PhD(UMelb)
Senior Technical OfficersThaHlaR,BRTC(TAFE)ZhouJ,BMed,(BeijingMedicalUniversity),MMed(USyd)(untilMarch)
Technical OfficerTanA,BBioTech(Hons)(fromApril)
Laboratory Technician JianP(part-time)
Predictive Medicine Group (transferred to Division of Molecular Bioscience from July)
Vaccine Immunology GroupProfessor and LeaderRamshawIA,MSc(Brunel),PhD
FellowThomsonS,BSc(USyd),PhD(UQ)(untilOctober)
Research FellowRanasingheC,BSc(Rouen),MPhil(Colombo),PhD(UWA)
NHMRC Peter Doherty Postdoctoral FellowAmyesE,DPhil(Oxon)
Postdoctoral FellowJuelichT,BSc(Hons)(Stuttgart),PhD
Visiting FellowsJacksonRJ,BSc(Hons)(Monash),PhD(Edin)RamsayAJ,BSc,PhD(Otago)
Research AssistantHarrisonJ,BSc(Hons)(Adel)(untilJuly)
Laboratory ManagerMedveczkyCJ,AssocDipTechBiol(TAFE)
Senior Technical Officers McArthurC,BSc(Flinders),MSc(untilFebruary)ShoobridgeM,BSc(Hons)(untilSeptember)
Technical Officers GaoK,BSc(ShanDong),MPhilNolanL,BAppSci(UC)WoltringD,AssDipBiol(CIT),AssDipPath(CIT),BSc(untilMarch)
Visiting Technical OfficerBeaton,S,HNC(Scotland)
Viral Immunology and Molecular Virology Group Professor and Joint LeaderMüllbacherA,BSc,MSc(Auck),PhD
Fellow and Joint LeaderLobigsM,BSc(Hons),PhD
Research FellowsLeeE,BSc(Hons),PhDRegnerM,PhD
Postdoctoral FellowAlsharifiM,BBioMedSci(Hons)(Monash),PhD
Visiting FellowsAllevaLM,BSc(Hons),PhDBettadapuraJ,MSc,PhD(Bangalore)(fromJune)BlandenRV,MDS(Adel),PhD,FAABuddAC,BSc(USyd),BSc(Hons),PhDChinJ,MSc(Hons)(UQ),PhD(UQ)CooperPD,DSc,PhD(ULond)(fromMay)WaringP,BSc(Hons)(UQ),MSc,PhD
Senior Technical OfficersKoskinenA,AssocDipMedSciPavyM,AssocDipAppSc(CIT)(fromAugust)
Technical OfficersLobigsP,AssocDipMedSci(fromOctober)PavlinovicL(fromApril)PavyM,AssocDipAppSc(CIT)(untilAugust)SmythV(fromMay)
Visiting ScholarLauerN(fromSeptember)
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Presentations 2006
Division of Immunology & Genetics
Presentations 2006
Dr EM BertramLarge scale ENU variation of the mammalian genome: linking causal relationships between genes and immunityNational Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA
Large scale ENU variation of the mammalian genome: linking causal relationships between genes and immunityNational Human Genome Research Center, National Institutes of Health, Bethesda, MD, USA
Large scale ENU variation of the mammalian genome: linking causal relationships between genes and immunityInstitute of Systems Biology, Seattle, WA, USA
Large scale ENU variation of the mammalian genome: linking causal relationships between genes and immunityKings College, London, UK
Large scale ENU variation of the mammalian genome: discovery of a novel gene variant Thunder with reduced T cells in the peripheryImmunology Group of Victoria, Beechworth, VIC
Molecular and Cellular Analysis of the ENU-induced Mouse gene variant, Face, with a point mutation in STAT-1 responsible for spontaneous T cell hyperactivity1st Joint Meeting of European National Societies of Immunology - 16th European Congress of Immunology, Palais des Congrès, Paris, France
LIGHT deficient mice show enhanced recruitment of antigen specific CD8+ T cells into the lung following intranasal influenza virus infection1st Joint Meeting of European National Societies of Immunology - 16th European Congress of Immunology, Palais des Congrès, Paris, France
Professor CC GoodnowMouse models as the rosetta stone for human genome-phenome research, Future of Genetics ForumAustralian Genome Alliance, Parliament House, Canberra, ACT
Alternative approaches to find novel pathways in immunologyEURAPS Meeting, Uppsala, Sweden
The genetics of autoimmunityThe Dunn School of Pathology, Oxford, UK
Genes and mechanisms that prevent autoimmune diseaseMcGill University, Montreal, QC,Canada
Immunological tolerance: how many mechanisms and how many genes?Dan H Campbell Memorial Lecture, The 2006 Midwinter Conference of Immunologists at Asilomar, Pacific Grove, CA, USA
Genes and mechanisms that prevent autoimmune disease,The Scripps Research Institute, San Diego, CA, USA
Genome-wide approaches to discover immune regulators11th International Conference on Lymphocyte Activation and Immune Regulation, Newport Beach, CA , USA
Genes and mechanisms for immunological self-tolerance: how many and which ones fail in autoimmune disease?King’s College Medical School, Guy’s Hospital, London, UK
Animal and plant genomics and post-genomicsThe University of Sydney-The Australian National University Co-operation Agreement Planning and Review Workshop, Sydney, NSW
Opening and Closing RemarksDecoding the Genomic Control of Immune Reactions, Novartis Symposium, Canberra, ACT
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Autoimmunity and allergy due to inherited genes causing quantitative variation in the TCR signalosome: differential effects on thymic positive, negative and Foxp3 cell selectionThymOz V - An International Workshop on T Lymphocytes, Heron Island, QLD
Ubiquitin ligases: critical inhibitors for immunological self-toleranceGarvan Institute Symposium on Ubiquitin, Sydney, NSW
Mechanisms and genes inhibiting autoimmunity: many movings parts prone to failureDistinguished Lecture, American Association of Immunologists, Boston, MA, USA
The Laboratory mouse: the rosetta stone for translating genes into healthAustralian and New Zealand Society for Animal Laboratory Science, Conference, Canberra, ACT
Genes and mechanisms preventing autoimmunityBernard Halpern Symposium of Immunology, Paris, France.
Genetic analysis of t-cell regulationPeter MacCallum Cancer Centre, Melbourne, VIC.
Translating the genome sequence into health: how many genes protect us from autoimmune disease and which are they?Edwards Orator, 3rd Australian Health & Medical Research Congress, Melbourne, VIC
Dr C FreemanHeparan sulphate mimetics14th Symposium on Glycosaminoglycans, Villa Vigoni, Loveno di Menaggio, Como, Italy
Roles of heparan sulfate in inflammationManchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, Manchester, UK
Development of HS mimetics as anti-cancer drugsDepartment of Medical Oncology, Cancer Research UK and the University of Manchester, Christie Hospital NHS Trust, Manchester, UK
Dr G HoyneCurrent Symposia on Regulatory T cells and NK CellsAustralian Society of Immunology, Melbourne, VIC
The role of the novel splicing silencer hnRNPL in T cell homeostasis and functionJCSMR Retreat, Canberra, ACT
Identifying genes that oppose Type 1 diabetesJDRF Workshop for Centre and PPG holders, San Francisco, CA, USA
Dr G KarupiahRole of antibody responses in 1o and 2o poxviral infectionsBiodefense Clinical Research Workshops, National Institutes of Health, Bethesda, MD, USA
Immune response to viral infection8th Federation of Immunological Societies of Asia-Oceania (FIMSA)/IIS Advanced Immunology Course in Immunology, New Delhi, India
Genes and mechanisms of viral immunityNovartis Foundation Symposium - Decoding the Genomic Control of Immune Reactions, Canberra, ACT
Genetic resistance to smallpox: Lessons from mousepoxNovartis Foundation The Australian National University and Australian Phenomics Facility - Decoding the Genomic Control of Immune Reactions, Canberra, ACT
The Mousepox Model: a powerful tool to study immunity to poxvirusesFASEB Summer Research Conference on Poxviruses, Indian Wells, CA, USA
Dr P ManaLIGHT deficient mice show enhanced recruitment of antigen specific CD8+ T cells into the lung following intranasal influenza virus infection.Keystone Symposia: Advances in Influenza Research, Steamboat Springs, CO, USA
Professor C ParishVaccines and immunotherapeutics: Current trends and future developmentsAustralasian Vaccine and Immunotherapeutics Development (AVID) Conference, Melbourne, VIC
Targeting liposomes to dendritic cells: A new approach to vaccine development8th Annual Mater Medical Research Institute Dendritic Cell Symposium, Brisbane, QLD
From angiogenesis to platelets and eosinophils: a multifaceted approach to cancer control16th St Vincent’s and Mater Health Research Symposium, Sydney, NSW
Division of Immunology & Genetics
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Presentations 2006
Heparan sulfate and platelets: Two important components of the tumour microenvironment that regulate tumour growth and metastasisHunter Medical Research Institute Conference on Translational Cancer Research, Newcastle, NSW
Heparanase and heparan sulfate: Key regulators of angiogenesis and tumour metastasis8th International Symposium, Victor Chang Cardiac Research Institute, Sydney, NSW
Heparan sulfate mimetics: A new class of therapeutic agentsHeart Research Institute, Sydney, NSW
Heparan sulfate: A key regulator of inflammatory responses36th Annual Scientific Meeting of the Australasian Society for Immunology, Auckland, New Zealand
Dr CG VinuesaThe zinc-finger protein Roquin in autoimmune disease36th Annual Meeting of the Japanese Society for Immunologists, Osaka, Japan
Genetic and cellular mechanisms regulating autoimmunity and self toleranceSymposium on Immunogenetics, Hospital de Valdecillas, Santander, Spain
The Roquin pathway in autoimmunity1st International MUGEN Conference - Animal Models of Human Immunological Diseases, Athens, Greece
Genetic control of autoimmunity and memoryDecoding the Genomic Control of Immune Reactions. Novartis Symposium, Canberra, ACT
Roquin maintains tolerance in germinal centres 1st Joint Meeting of European National Societies of Immunology - 16th European Congress of Immunology, Palais des Congrès, Paris, France
Roquin acts in stress granules to maintain tolerance in follicular helper T cells Annual Brisbane Immunology Group (BIG) Scientific Retreat, Gold Coast, QLD
Division of Immunology & Genetics
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006 Division of Molecular Bioscience
Professor and Head of DivisionShannonMF,BSc(Hons),PhD(NationalUniversityofIreland)
Divisional AdministratorMastorisR
Allergy and Inflammation Research GroupProfessor and Group LeaderFosterP,BSc(Hons)(UWA),PhD
Laboratory TechnicianCaiY,BMed(BeijingMed)
Asthma and Allergy GroupFellow and LeaderWebbDC,DipMedLabSc(RMIT),BAppSc(UC),PhD(UC)
Postdoctoral FellowZhouJ,BMed(GuangxiMed),MMed(GuangxiMed),PhD
Laboratory TechnicianCaiY,BMed(BeijingMed)
Biomolecular Structure LaboratoryFellow and LeaderCasarottoMG,BSc(Hons)(UMelb),PhD(UMelb)
Research FellowHarveyP,BSc(Hons)(Griffith),PhD(Griffith)
Postdoctoral Fellows CuiY,MA(CentralChina),PhD(ChineseAcademyofScience)CraigS,BSc(Hons)(UNSW),PhD(UNSW)
Technical OfficersHekimianL,DipLabTech(CIT)KarunasekaraY,MD(USSR)
Cancer and Molecular Immunology Group(transferred from Division of Immunology and Genetics from July)
Fellow and LeaderHulettM,BSc(Hons)(UMelb),PhD(UMelb)
Senior Technical OfficerHornbyJ,BSc(Hons)(Queens,Belfast)
Technical OfficerEichnerD,BSc(Hons)(untilAugust)PaglerE,BSc(SantoTomas)
Chromatin and Transcriptional Regulation LaboratorySenior Fellow and LeaderTremethickDJ,BSc(Hons)(USyd),PhD(MacqU)
Research FellowsRidgwayP,BSc(McMaster),MSc(Queens,Canada),PhDFanJ,BSc(Fudan),MSc(Fudan),PhD(Auckland)RangasamyD,BSc,MTech(India),PhD(Hull)
Postdoctoral FellowGreavesI,PhDSobolevaT,MSc(MSU),PhD(fromMay)
Technical OfficerDevoyM,BSc(Hons)
Laboratory TechnicianYoungS(casual)
Computational Genomics Laboratory (transferred from Division of Immunology and Genetics from July)
Fellow and LeaderHuttleyG,BSc(Hons)(MacqU),PhD(UCRiverside)
Scientific ProgrammerMaxwellP,MSc,DipCompSci(Auckland)
Research ScholarsSammutR,BAppSc(Monash),BEc(Monash)LindsayH,BMathSci(Newcastle),BSc(Hons)(fromFebruary)
Research FellowSchranz,H,BSc(Hons)(USyd),PhD(USyd)
Computational Proteomics and Therapy Design GroupProfessor and LeaderGreadyJE,BSc(Hons),PhD(USyd)FRACI
Research OfficersCumminsPL,BSc(Hons),PhD(USyd)RostovIV,BSc(Kazan),PhD(KarpovInstitute)(part-time)
Postdoctoral FellowKannappanB,BSc(Madras),MSc,PhD(Pune)
Research AssistantAlonsoH,MSc(Cordoba)(fromSeptember)
Visiting FellowsArmaregoWLF,PhD,DSc(ULond),FRSC,FRACIBliznyukA,BSc,PhD(Novosibirsk)GravesJAM,BSc,MSc(Adel),PhD(UCBerkeley)
Visiting International Postdoctoral FellowSangiorgioL,Laurea(VetBiotech),PhD(Milan)
Cytokine Gene Expression LaboratoryProfessor and LeaderShannonMF,BSc(Hons),PhD(NationalUniversityofIreland)
Staff 2006
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Staff 2006
Division of Molecular Bioscence
Postdoctoral FellowsWilkinsonN,PhD(Texas)(untilSeptember)WangJ,BSc(Xinjiang),MSc(WeizmannInstitute),PhDHardyK,BSc(Hons)(USyd),PhD(USyd),Masters(EScience)BuntingK,BSc(Hons)(Adel)PhD(fromAugust)
Senior Technical Officer and Laboratory ManagerPalmerS,BSc(Hons),GradDip(TechManagement)(Monash)
Technical OfficerMaL,MAppSci(Horticulture)(NZ)
Cytokine Molecular Biology and Signalling GroupProfessor and Group LeaderYoungIG,MSc(UMelb),PhD
Postdoctoral FellowsSobolevaT,MSc(MSU),PhD(untilMay)ChenJ,BSc(China),MMed(China),PhD(Flinders)
Research AssistantFordS,BA,MSc(UQ)
Technical OfficersOlsenJ,BScWalkerA,BSc(Hons)(fromFebruary)
Gene Targeting LaboratoryAssociate Professor and HeadKIMatthaei,BSc(Hons)(UNSW),PhD
Visiting FellowsHopkinsonK,DipAppSc(UC),BScApp(UC),DipAPMA(Monash)FreseM,BSc(Osnabrück),PhD(Freiburg)(fromJuly)MegirianD,PhD(Rochester)(fromDecember)
Visiting ScholarMatthaeiNK,BA(Hons)(QUT)
Laboratory TechniciansDamcevskiVW,AssocDipAppSci(CIT)TaylorHIKugathasK,DipMedLabSci(CIT)(untilFebruary)WardJ,BSc(Hons)(fromFebruary)GibsonP(part-time)
Membrane Physiology and BiophysicsResearch Fellow and LeaderTierneyML,BSc,MSc(Otago),PhD
Postdoctoral FellowsPremkumarA,BSc,MSc,PhDLuT,BSc(Hons),PhD
Visiting FellowsCromerB,BSc(Hons),PhD
EwartG,BSc(Hons),PhDOzsaracN,BSc(Hons),PhD
Technical OfficersCurmiJ,BOptom(Hons)WeiB,BMed(China)
Molecular Genetics GroupProfessor and LeaderBoardP,BSc(Hons),PhD(UNE)
Research FellowBlackburnA,BSc(Hons)(UNSW),PhD
Postdoctoral FellowsShieldA,BBiotech(Hons)(Flinders),PhD(Flinders)CraigS,BSc(Hons)(UNSW),PhD(UNSW)LiuD,PhD(USyd)
Visiting FellowDahlstromJ,MBBS(Hons),FPAC,PhD,FRCPA,GradCertEdSt
Senior Technical OfficerCogganM,BSc(Hons)
Laboratory TechniciansCappelloJ,BSc(UC),ADAppSciAnSci(CIT)KarunasekaraY,MD(Vinnitsa)MurrayT,BSc(Hons),BMedSci(USyd)RookeM,BMedSci(PharmSci)(CSU)
Muscle Research GroupProfessor and Group LeaderDulhuntyAF,BSc(USyd),PhD,DSc(UNSW)
Postdoctoral FellowBeardN,BAppSci(Hons)(LaTrobe),PhDKimuraT,BSc(Hons)(Osaka),PhD
Research FellowPouliquinP,BSc(Hons)(Ferrara)
Visiting FellowLaverD,BSc(Hons),PhD(UNSW)
Technical OfficerCurtisS,BSc,PLTC(halftime)
Senior Technical OfficersPaceS,BSc(UTS)GallantE,PhD(Minnesota)
Laboratory TechniciansStivalaJCulleyD,BSc
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Division of Molecular Bioscence
Presentations 2006
Predictive Medicine Group (transferred from Division of Immunology and Genetics from July)
Professor and LeaderEastealS,BSc(StAndrews),MBA,PhD(Griffith)
Visiting FellowMackH,BSc,PhD(PennState)
Senior Technical OfficerTanX,BSc,(Shandong),MSc(ChinaPharmaceutical)
Visiting ScholarMatherK,BSc(Hons)(LaTrobe),BSc(Hons),GradDipPsy(CSU)
Ubiquitin LaboratoryFellow and LeaderBakerRT,BSc(Hons)(UNSW),PhD
Technical OfficerMcIntyreM,BSc(Hons)(UWA),GradDipEd(UC)
Laboratory TechnicianBrewJM,BSc(Hons)(March-June)
Divisional Visiting FellowsBarlinG,PhD,DSc(USyd),FRANCCoxG,BSc,PhD(UMelb),FAADenboroughM,MD,ChB(CapeTown),MD(UMelb),DPhil(Oxon),DSc(UMelb),FRCPGibsonFEW,BSc,DSc(UMelb),MA,DPhil(Oxon),FAA,FRSMorrisonJE,BSc(USyd),MSc(UQ),DPhil(Oxon),DScSpinnerE,MScTech,PhD,DSc(Manchester),FRACI
Dr RT BakerRegulation of ubiquitin-dependent functions by deubiquitylationInternational Fellow’s Symposium, Garvan Institute of Medical Research, Sydney, NSW
Ubiquitin: getting it on and getting it offCentre for Vascular Research, The University of New South Wales, Sydney, NSW
Professor P BoardDeficiency of glutathione transferase Zeta causes oxidative stress and sensitivity to acetaminophen ISSX 1st Asia Pacific Symposium, Juju Island, South Korea
Professor A DulhuntyA variably spliced region of the RyR is implicated in myotonic dystrophy and EC couplingDepartment of Physiology and Pharmacology, The University of New South Wales, Sydney, NSW
A variably spliced region of the RyR is implicated in myotonic dystrophy and EC couplingDepartment of Cell Biology, University of Philadelphia, Philadelphia, PA, USA
Ryanodine Receptor Regulation by PeptidesHerzelya, Israel
Novel regulators of RyR Ca2+ release channels: Molecular changes in genetically linked myopathiesSpecial Session of the European Muscle Conference, Heidelberg, Germany
The muscle model for intracellular calcium signalling: cross-talk between the calcium release channel and the calcium buffer in the intracellular calcium storeComBio2006, Brisbane, QLD
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Presentations 2006
Division of Molecular Bioscence
Professor S EastealH+; The future of human evolutionDefence Science and Technology Organisation Conference Human Performance, Melbourne, VIC
Dr M HulettThe heparan sulphate degrading enzyme heparanase: molecular characterisation and targeting with drug inhibitors to treat cancer and inflammatory disease Department of Biochemistry, La Trobe University, Melbourne, VIC
The heparan sulphate degrading enzyme heparanase: molecular characterisation and targeting with drug inhibitors to treat cancer and inflammatory diseaseLudwig Institute for Cancer Research, Melbourne, VIC
Regulation and Function of the heparan sulphate degrading enzyme heparanase in cancer and inflammation The Australian Health and Medical Research Congress, Melbourne, VIC
The heparan sulphate degrading enzyme is induced in T cells upon activation and promotes infiltration of CD4+ T cell in EAE 36th Annual Scientific Meeting of The Australian Society for Immunology, Auckland, New Zealand
The heparan sulphate degrading enzyme heparanase: Molecular characterisation and targeting with drug inhibitors to treat cancer and inflammatory diseaseMenzies Research Institute, Hobart, TAS
Dr G HuttleyApplication of the COmparative GENomics Toolkit (COGENT) to examining the evolution of DNA’s 5th base, 5-methyl-cytosineInternational Human Genetics Congress, Genetics Society of Australia, Brisbane, QLD
Dr K MatthaeiPlenary Lecture: Gene targeting and transgenics: Providing all the answers or just more problems2nd International Congress on Stem Cell Biology & Technology, Tehran, Iran
Tissue and temporal control of gene expression in vivo2nd International Congress on Stem Cell Biology & Technology, Tehran, Iran
Professor MF ShannonGene transcription in the post-genomic era Keynote speaker - Functional Genomics Workshop, Canberra, ACT
The role of the NF-kB transcription factor c-Rel in T cell gene transcription ComBio2006, Brisbane, QLD
Gene transcription in the immune system: single gene and genome-wide approachesSchool of Molecular Bioscience, The University of Adelaide, Adelaide, SA
Dr ML TierneyTrafficking by GABARAP produces “super” GABA-A channels ComBio2006, Brisbane, QLD
The conductance of recombinant GABA-A receptors with GABARAP American Biophysics Society, Salt Lake City, Utah, USA
Trafficking by GABARAP turns GABA-A receptors into “super channels”Gordon Conference on Ion Channels, Tilton, New Hampshire, USA
Dr D TremethickH2A variants: modulators of higher-order chromatin structure The Gordon Conference on Chromatin Structure and Function, Ciocco, Italy
Partitioning the genome into distinct and dynamic functional domains by modulating chromatin structureGene Expression and Chromatin Symposium, Massey University, Auckland, New Zealand
Dr D WebbThe roles of IL-4, IL-13 and IL-4Rα in modulating pulmonary dendritic cells and their functional interaction with CD4+ T cellsAustralasian Society for Immunology, Auckland, New Zealand
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Head of DivisionStuartGJ,BSc(Hons)(Monash)PhD
Divisional AdministratorElugaM
Autonomic Neuroeffector Transmission LaboratoryProfessor and LeaderHirstGDS,BSc,PhD(Leeds),FAA
FellowsEdwardsFR,BE,PhD(Monash)YanagidaH,MD,PhD(Nevada)
Laboratory TechnicianGarcia-LondonoAP,BVSc(Caldas)
Blood Vessel LaboratoryProfessor and LeaderHillCE,BSc,PhD,DSc(UMelb)
Postdoctoral FellowEllisA,BSc(Monash),BApplSc(RMIT),PhD(RMIT)(fromSeptember)
Visiting FellowGraysonTH,BSc(UTas),MSc,PhD(Plymouth)
Visiting Technical OfficerBrackenburyT,BSc(Hons),BSc(Natal),MSc,PhD(untilSeptember)
Research OfficerBelfrageKR,BSc(Hons)(LaTrobe)
Cerebral Cortex LaboratoryFellow and LeaderBekkersJM,BSc(Griffith),MSc(Manchester),PhD(Cambridge)
Postdoctoral FellowSuzukiN,BSc(Tsukuba),MMedSc(Tsukuba),PhD(Tokyo)
Research AssistantChenMM,MSc(Liaoning),PhD(Shanghai)(fromSeptember)(part-time)
Developmental Neurobiology LaboratoryProfessor and LeaderHendryIA,BSc(Med),MBBS(USyd),PhD(Cambridge),DSc(USyd)
Laboratory TechnicianHolgateJ,BAppSc(UC)
Postdoctoral FellowKaasinenSK,MSc,PhD(Kuopio)
Visiting FellowMegirianD,MS,PhD(Rochester)
Movement & Memory LaboratoryProfessor and LeaderRedmanSJ,ME(UNSW),PhD(Monash),DSc(Monash),FAA
University Fellow and Emeritus ProfessorCurtisDR,AC,MBBS(UMelb),PhD,FRACP,FAA,FRS
Research FellowsCowanAI,BSc(Hons),PhD(untilSeptember)RaymondC,BSc(Hons)(Otago),PhD(Otago)
Senior Technical OfficerRoddaGR,PTC
Neuronal Network LaboratoryAssociate Professor and LeaderStrickerC,MD(Zurich),PhD(Bern)
Neuronal Signalling LaboratoryLeaderStuartGJ,BSc(Hons)(Monash),PhD
Postdoctoral FellowsKoleMHP,MSc,PhD(Groningen)IlschnerS,MD,PhD(Erlangen)(fromAugust)BretonJ-D,MSc,PhD(Strasbourg)(fromDecember)
Synapse & Hearing LaboratoryProfessor and LeaderWalmsleyB,BE,PhD(Monash),DSc(UNSW)
Postdoctoral FellowsBerntsonA,BA(Minnesota),PhDLeaoR,BSc,MD(UFU),PhD
Visual Neuroscience LaboratoryProfessor and LeaderLambTD,BE(UMelb),ScD(Cambridge),FRS,FAA
Postdoctoral FellowsCameronAM,BPsych(Hons)(JCU),PhD(UQ)JärvinenJLP,MSc(Helsinki),PhD(Cambridge)RuseckaiteR,BSc(VytautasMagnus),MSc(VytautasMagnus),PhD(fromSeptember)VogalisF,PhD(Monash)(fromNovember)
Research OfficerMiaoL,BEng(Tongii),MEng
Division of Neuroscience
Staff 2006
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Presentations 2006
Division of Neuroscience
Presentations 2006
Professor T LambPhototransduction, dark adaptation and rhodopsin regenerationThe Proctor Lecture 2006, Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, USA
Functional differences between rods and cones: Kinetics, sensitivity, noise, operating range, and recovery from bleachesECVP2006, European Conference on Visual Perception, St Petersburg, Russia
Phototransduction, dark adaptation and rhodopsin regenerationPlenary Lecture, Australian Ophthalmic and Visual Sciences Meeting, Canberra, ACT
Son of a bleach: Recovery of visual sensitivity in human retinal bipolar cells following intense illumination“Seeing Connections” satellite meeting of the Australian Neuroscience Society, The University of Sydney, Sydney, NSW
Dark adaptation of human retinal rod bipolar cellsSchool of Biomedical Science, University of Queensland, Brisbane, QLD
Dark adaptation of human rod bipolar cellsCraik Club seminar, University of Cambridge, Cambridge, UK
Professor C HillEndothelial derived hyperpolarizing factor, gap junctions and hypertensionCardiovascular Research Centre, University of Virginia School of Medicine, Charlottesville, VA, USA
Endothelial derived hyperpolarizing factor, gap junctions and hypertensionDepartment of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Cardiff, Wales
Endothelial derived hyperpolarizing factor, gap junctions and hypertensionDepartment of Pharmacology, Oxford University, UK
Endothelial derived hyperpolarizing factor, gap junctions and hypertensionPrince of Wales Medical Research Institute, Sydney, NSW
Dr GJ StuartIntegration of synaptic input in somatosensory cortex 5th Annual Satellite on Motor Control, Sydney, NSW
Investigating synaptic integration with voltage-sensitive dyes 25 Years of Giga-Seal Patch Clamping, Heidelberg, Germany
Dendrites and synaptic plasticityUniversity of Newcastle, Newcastle, NSW
The cerebral hardware of mammalian and human brainsStars to Brains meeting, Canberra, ACT
Learning rules for spike timing-dependent plasticity depend on dendritic synapse location ComBio2006, Brisbane, QLD
Dendrites and synaptic plasticityAnderson Stuart Seminar Series, The University of Sydney, Sydney, NSW
Methods for dendritic patch-clampingDendritic Patch-Clamp Workshop, London, UK
Dr C RaymondLocation, location: Spatial segregation of neuronal calcium signals encodes different forms of LTPQueensland Brain Institute, University of Queensland, Brisbane, QLD
Professor SJ RedmanAdventures with synaptic plasticity: calcium and quanta Australasian Winter Conference on Brain Research, Queenstown, New Zealand
Professor B WalmsleyCentral brainstem processing of auditory signalsWinter Conference on Brain Research, Steamboat Springs, CO, USA
Endbulbs and calyces of Held, and neuronal firing properties in congenitally deaf miceSymposium on the Calyx of Held, Leipzig University, Leipzig, Germany
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Staff 2006
High Blood Pressure Research Unit
Presentations 2006
Professor and HeadWhitworthJA,AC,DSc,MD,PhD,BS(UMelb),MD(Honoriscausa)(USyd),MD(Honoriscausa)(UNSW),FRACP,FAICD
Research FellowZhangY,BMed(Beijing),PhD(Adel)
Clinical Research AssistantWilliamsonPM,SRN(secondedtoStGeorgeHospital,Sydney,NSW)
Laboratory ManagerMcKenzieKUS,AssDipAppSci,ITCertIII(CIT)(untilJune)
Senior Technical OfficerLangtonLK,BSc
Technical OfficerVickersJJ,BSc(UC),RN,RM
Visiting FellowKellyJJ,MBBS(Hons),MD(UNSW)
Professor JA WhitworthImportance of government support and legislation at a national levelInternational Society of Hypertension CVD Prevention meeting, Istanbul, Turkey
Glucocorticoids, hypertension and cardiovascular riskThe 21st Annual Scientific Meeting of The International Society of Hypertension, State of the Art Lecture, Fukuoka, Japan
Medical research in AustraliaEngineers Australia (Canberra Division), Canberra, ACT
Global communication and global healthWomen in Information and Communication, Canberra, ACT
Opening addressCardiac Society of Australia and New Zealand, 54th Annual Scientific Meeting, Canberra, ACT
Hypertension: a global health problem14th Annual Scientific Meeting, Australian Vascular Biology Society, Gold Coast, QLD
Great public service debateAustralian Public Service Commission, Sydney, NSW
Designer babies: a threat to mankindRotary Great Debate, Canberra, ACT
Health research: The best investmentUnion Club, Sydney, NSW
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Students at JCSMR 2006
PhD ScholarsAbrahamM,BSc(UTas),MPhil
AlonsoH,MSc(Cordoba)
ArsovT,MD(StCirilusandMethodius),MS(StCirilusandMethodius)(untilAugust)
AzmanovD,MD(Thracian)
BrewJ,BMedSci(Hons)
BrownK,BSc(Hons)(Murdoch)(untilSeptember)
BuntingK,BSc(Hons)
ChakkaN,BDS(Bangalore)MSc(Bioinformatics)(EastAnglia)
ChenX,BSc(Hons)
CheungS,BSc(fromMarch)
CorleyS,BLaw(UQ),MLaw,BSc(Hons)(USyd)
CorrechaM,MBBS(Cauca)
CouplandL,BSc(Hons),RN(fromMarch)
DayS,BBioTech(Hons)
DixonC
EllisL,BAppSci(UC)
EllyardJ,BAs,BSc(Hons)
EverittA,BSc(untilNovember)
FarnsworthM,BSc(Wollongong),BSc(Hons)
FleningE,BSc(Hons)(UNSW)(untilJanuary)
ForbesE,BSc
FrenchH,BSc(Hons)
HarleyN,BSc(Hons)
HeY-Q,MSc(SunYat-Sen)
HoranC,BMedSci(Hons)
IkedaK,BA(UCBoulder)
KuoI,BSc(BioMed)(UWA),BSc(Hons)
LeangL,BSc(Hons)(Monash)(fromMarch)
LeaoK(neeSvahn),BSc,MSc(Gothenburg)
LeeS-H
LefflerM,BMedSci(Hons)(MacqU)
LetzkusJ,DipBiol(Mainz)
LindsayH, BMathSci(Newcastle),BSc(Hons)(fromFebruary)
LintermanM,BBMEDS(Victoria,Wellington)(fromJanuary)
McCuaigR,BSc(UC),GradDipSciMolBiol,BSc(Hons)(UTas)
McNaughtonE,BSc(Hons)(Otago)(fromFebruary)
MdNorN,MSc(Nottingham)(fromDecember)
MirzaS
MooreA,BSc(Massey)
MorrisM,BMedSci(Hons)(JCU)
MuraseT,BSc(Hons)(untilNovember)
Navarro-GonzalesM,BVSc(Caldas)
NgE,BMedSc(Hons)
O’CallaghanN
OngS,BSc(Med)MBBSFRACP
PalmerL,BSc(UMelb),BA(UMelb),MSc(Minnesota)
PenaJ
PoonI,BBioMedSci(Hons)(Monash)(fromFebruary)
PrescottV(neeSmart),BSc(Hons)
PrichardZ,BSc(Hons)
RandallK,MB(UNSW),BS(UNSW),BSc(UNSW),FRACP,FRCPA(fromFebruary)
RosenbergM,BSc(Hons)(Canterbury)
SakalaI,BMedSc(Zambia)
SammutR,BAppSc(Monash),BEc(Monash)
ScottB,BSc,PGDip(UQ)
SeymourV,BSc(Hons)(Otago)
SheahanD,BSc(Hons)
SimpsonN,MBBS(USyd),MPH(UNSW)
SinghalS,BSc(Hons)(Delhi),MSc(BioTech)(Punjab)
SjollemaG,BSc(untilJuly)
SochaLH,MD(ColombianNational),GradCertClinicalTrialsManagement(UC)
SontaniY,BSc(Murdoch)
StorerJ,BBioTech(Hons)(Wollongong)
SutcliffeE,BSc(NTU),BSc(Hons)
SutherlandD,BMedSi(Hons)(fromJune)
TaeHS,BSc(Hons)(Malaysia)
TaylorM,BSc,MPhil
TranT
VassilievaT
WangZ,MSc(Wollongong)
WeiL
WeissSB,BAppSc,PhD,MFinMgt
WenB
WoodR,BSc(Hons)(JCU)
WuZ,MSc(UNSW),BM(ZhongShan)
YoussoufianM,BSc(California),BSc(Hons)
YuD,BSc(Wuhan)
ZeidO,MD(Cairo)(untilOctober)
ZhangJ,BMSc(Hunan)(untilOctober)
ZiolkowskiA,BSc(Hons)
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Students
Stud
ents
200
6
MPhil ScholarsBrownK,BSc(Hons)(Murdoch)(fromSeptember)
HuX,BSc(BeijingInstituteofTechnology)(fromMay)
KwokA,BSc(Hons)
YingH,BBiolPharmEngineering(Nanjing),MSBiochemMolBiol(Nanjing)
Honours StudentsAltinJ
BotelhoN
CheungBKW
ChuaG
GyngellC
HoY
LamK
NgJ
SchultzN
SivakumarB
SivalingamI(untilJune)
SubramanianA(untilJune)
TanEJ
International ScholarsNanyakkaraB
PauloS
SalomäkiM
SpillmanN
VäisänenM
Research StudentsTehC
LuMC
EvansE
RamanayakeN
ArnettS
KumarS
GunaratnaK
SlaterJ
AltinJ
JainG
Rese
arch
Pro
gram
s
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School Administration & Services
School Administration School Services
School AdministrationHoward Florey Professor of Medical Research and
DirectorWhitworthJA,AC,DSc,MD,PhD,BS(UMelb),MD(Honoriscausa)(USyd),MD(Honoriscausa)(UNSW),FRACP,FAICD
Deputy DirectorRedmanSJ,ME(UNSW),PhD(Monash),DSc(Monash)FAA
Business ManagerWebbB,BRTC(CIT),AdvDipBusMan(CIT)
School VisitorFennerEmeritusProfessorF,AC,CMG,MBE,FRS,FAA,MD,DTM,HonMd,Drhonoriscausa(Liege),FRACP,FRCP(ULond)
Convenor, Graduate Program in Medical Sciences (transferred to ANU College of Medicine and Health Sciences from September) CowanA,BSc(Hons),PhD,GradCertHE
Public Affairs Officer (transferred to ANU College of Medicine and Health Sciences from July) NicolMJ,BSc(Wollongong),BSc(Hons),PhD
Safety & Training Officer CreganA,BSc(untilApril)
Executive Assistant to DirectorJacobsenAJ,CertFrontlineManagement
Administrative AssistantsMoralesDPriestK(untilJune)
Functions AssistantRathboneGK(fromSeptember)
School ServicesAnimal ServicesHeadReidA,MIAT(UK)HNCBiologicalSciences
Deputy HeadMcMathH,MIAT(UK)HNCBiology(fromSeptember)MetcalfeC,CertVetNursing,CertFrontlineManagement(untilSeptember)
Office AdministrationHargraveT
Divisional VeterinarianBainSAF,BVSc(USyd),MACVSc(part-time)
Senior Technical OfficersGoodingDRichardsonJWilsonJ(fromSeptember)
Technical OfficersBurkeHComansCFaucettTPorrittTSuttonM
Animal TechniciansBowditchKBowesVBurkeBCoxSEarlMFigueroaSFookNO’SullivanEPeileM(fromSeptember)SpencerC(fromSeptember)WalkerK(fromSeptember)WilliamsN
Material Support TechniciansCoverGForgieIFowlieC(fromSeptember)HamiltonRHoganPJarvisLSantracCSparrowMViolanteOYoungS(part-time)
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Biomolecular Resource Facility (BRF)ManagerEdwardsK,BSc(Natal),BSc(Hons)(CapeTown),PhD(UniversityCollegeLondon),GradCertTertiaryTeaching(JCU),MEnvMng(UNE)(untilNovember)PalmerS,BSc(Hons),GradDip(TechManagement)(Monash)(fromNovember)(part-time)
Technical SpecialistMilburnP,BSc(Hons),PhD(Sheffield)
Microarray CoordinatorPengK,PhD(Wuhan)
Bioinformatics AnalystOhmsS,MBChB,ME,PhD(Auckland)
DNA sequencingMcCraeC,BiolTechCert(CIT)
Peptide SynthesisMcAndrewK,AssDipAppSci(UC)
Tetramer SynthesisSutherland,TBAppSci(CSU)(untilFebruay)ZhangK,MSc(Fudan),PhD(fromJuly)
Administrative AssistantMooreS
Finance and Research Support(Transferred to ANU College of Medicine and Health Sciences from July)
Finance Manager SawyerV
Senior Finance Officer SinnottT
Finance OfficersCousinsMTalbotM
Senior Purchasing OfficersHicksG(untilMarch)PradoL
Purchasing OfficersAllanN(untilApril)WrightN(fromJune)
Senior StorepersonClementsR (Transferred to JCSMR General Services from July)
StorepersonTalbotA (Transferred to JCSMR General Services from July)
General ServicesHeadElsburyS,BAppSc,GradDipMedLabTech
Operations ManagerMetcalfeC,CertVetNursing,CertFrontlineManagement,DipBus(fromOctober)
Operations AssistantCiuffetelliL(fromFebruary)
Senior StorepersonClementsR(fromJuly)
StorepersonTalbotA(fromJuly)
SecurityBarancewiczD(untilJanuary)(casual)BlinksellP(untilJanuary)CiuffetelliL(untilJanuary)LazarovZ(untilJanuary)SimpkinW(untilJanuary)WilliamsF(untilJanuary)(casual)
CleanersBellingN(untilJanuary)BourkeP(untilJanuary)BourkeR(untilJanuary)(casual)GrantDHattonM(untilJanuary)(casual)McVeyS(untilJanuary)WhiteN(untilJanuary)WilliamsF(untilJanuary)(casual)WilliamsJ(untilJanuary)(casual)
Human Resources (transferred to ANU College of Medicine and Health Sciences from July)
Manager BrowningKO
HR OfficersJonesED(May–August)MurphyMMSmithBATalbotJA
HR Assistant OfficerBurkettSN
School Services
Staf
f 20
06
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Staff 2006
School Services
Information Technology & Communications Unit (ITCU)(transferred to ANU College of Medicine and Health Sciences from July)
HeadCollisA,BIT,BE(Hons)
Network ManagerZhangQ,BComputerSci(Beijing),MBA
ProgrammerColeP(untilFebruary)
Client Support Team LeaderHendersonS,TeachCert(ULond)
Client SupportFisherDHodgkinsDMcCullochASimeD,ElectronicsCert(untilAugust)
Multimedia (transferred to ANU College of Medicine and Health Sciences Outreach Group from July)EdwardsK,PhotCertFenningM,PhotCert,AAIPP(untilAugust)
Media/Wash-Up Section ManagerWoodhamsCE,(untilSeptember)MetcalfeC,CertVetNursing,CertFrontlineManagement,DipBus(fromOctober)
TechniciansGilmartinL,LabSkillCert3(CIT)MundayKThileebhanSBorrettD(fromNovember)(casual)
Microscopy and Cytometry Resource Facility (MCRF)HeadGillespieCM
Histology UnitPrinsAS,BAppSci(RMIT)
Flow Cytomtery UnitVohraH,MSc(Hons)(Punjab),PhD(PGIMER)DawsonS,BAppSci(UC)
Technical ServicesHeadCoombesD
Deputy HeadEmansP
Technical OfficersBestNChampionGCommonsRCremerPEllisonJGairLJakubaszekRJordanTKellyDKeysB(onsecondment)LangPPercivalMRhallGRobertsonASymonsC(untilNovember)TempraD
Administrative AssistantMcGannJ
ApprenticeBackhouseB
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Publications
The John Curtin School of Medical Research Annual Review 2006
Afulllistofpublications,includingpeerreviewedjournal
articles,invitedreviewsandbookchaptersauthoredbyJCSMR
staffandstudentsin2006appearsonthefollowingpages.
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JCSMR Publications
Abbey, JL, Hulett, M, and O’Neill, HC (2006) Cell surface expression of a peptide encoded by the unrearranged TCR-V beta 8.2 gene. Molecular Immunology 43(9): 1408-1417.
Adams, Y, Freeman, C, Schwartz-Albiez, R, Ferro, V, Parish, CR, and Andrews, KT (2006) Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides. Antimicrobial Agents and Chemotherapy 50(8): 2850-2852.
Alexander, WS, Viney, EM, Zhang, JG, Metcalf, D, Kauppi, M, Hyland, CD, Carpinelli, MR, Stevenson, W, Croker, BA, Hilton, AA, Ellis, S, Selan, C, Nandurkar, HH, Goodnow, CC, Kile, BT, Nicola, NA, Roberts, AW, and Hilton, DJ (2006) Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proceedings of the National Academy of Sciences of the United States of America 103(44): 16442-16447.
Alonso, H, Bliznyuk, AA, and Gready, JE (2006) Combining docking and molecular dynamic simulations in drug design. Medicinal Research Reviews 26(5): 531-568.
Alonso, H and Gready, JE (2006) Integron-sequestered dihydrofolate reductase: a recently redeployed enzyme. Trends in Microbiology 14(5): 236-242.
Alsharifi, M, Lobigs, M, Simon, MM, Kersten, A, Muller, K, Koskinen, A, Lee, E, and Mullbacher, A (2006) NK cell-mediated immunopathology during an acute viral infection of the CNS. European Journal of Immunology 36(4): 887-896.
Alsharifi, M, Regner, M, Blanden, R, Lobigs, M, Lee, E, Koskinen, A, and Mullbacher, A (2006) Exhaustion of type I interferon response following an acute viral infection. The Journal of Immunology 177(5): 3235-3241.
Altin, JG and Parish, CR (2006) Liposomal vaccines - targeting the delivery of antigen. Methods 40(1): 39-52.
Arita, I, Nakane, M, and Fenner, F (2006) Public health - Is polio eradication realistic? Science 312(5775): 852-854.
Arsov, T, Larter, CZ, Nolan, CJ, Petrovsky, N, Goodnow, CC, Teoh, NC, Yeh, MM, and Farrell, GC (2006) Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biomedical and Biophysical Research Communications 342(4): 1152-1159.
Arsov, T, Silva, DG, O’Bryan, MK, Sainsbury, A, Lee, NJ, Kennedy, C, Manji, SSM, Nelms, K, Liu, CN, Vinuesa, CG, and de Kretser, DM (2006) Fat Aussie - A new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Molecular Endocrinology 20(7): 1610-1622.
Attia, R, D’Este C, Schofield, PW, Brown, AM, Gibson, R, Tavener, M, Horsley, K, Harrex, W, Ross, J, and Team, S (2006) Mental health in F-111 maintenance workers: The study of health outcomes in aircraft maintenance personnel (SHOAMP) general health and medical study. (Ross, J on behalf of the SHOAMP team- JA Whitworth - Chair Advisory Committee). Journal of Occupational and Environmental Medicine 48(7): 682-691.
Baker, RT, (2006) Deubiquitinating enzymes, cell proliferation and cancer. Protein Degradation. Vol 3: Cell Biology of the Ubiquitin-Proteasome System. eds. RJ Mayer, A Ciechanover and M Rechsteiner. Wiley-Vch Weinheim pp.212 - 223
Banwell, MG, Bezos, A, Burns, C, Kruszelnicki, I, Parish, CR, Su, S, and Sydnes, MO (2006) C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties. Bioorganic and Medicinal Chemistry Letters 16(1): 181-185.
Blackburn, AC, Matthaei, KI, Lim, C, Taylor, MC, Cappello, JY, Hayes, JD, Anders, MW, and Board, PG (2006) Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Molecular Pharmacology 69(2): 650-657.
Blery, M, Tze, L, Miosge, LA, Jun, JE, and Goodnow, CC (2006) Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy. Journal of Experimental Medicine 203(7): 1773-1783.
Board, PG (2006) A class act - The discovery of the Theta class glutathione transferases. The Biochemist 28(5): 35-38.
Bulynko, YA, Hsing, LC, Mason, RW, Tremethick, DJ, and Grigoryev, SA (2006) Cathepsin L stabilizes the histone modification landscape on the y chromosome and pericentromeric heterochromatin. Molecular and Cellular Biology 26(11): 4172-84.
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Publications 2006JCSMR Publications
Bunting, K, Wang, J, and Shannon, MF (2006) Control of interleukin-2 gene transcription: a paradigm for inducible, tissue-specific gene expression. Interleukins. ed. G Litwack. Elsevier Academic Press Inc. Vol 74:105-145.
Burden, CJ, Pittelkow, Y, and Wilson, SR (2006) Adsorption models of hybridization and post-hybridization behaviour on oligonucleotide microarrays. Journal of Physics-Condensed Matter 18(23): 5545-5565.
Bystrom, J, Dyer, KD, Ravin, SS, Naumann, N, Stephany, DA, Foster, PS, Wynn, TA, and Rosenberg, HF (2006) Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5Ralpha in vivo. European Journal of Haematology 77(3): 181-90.
Cameron, AM, Mahroo, OAR, and Lamb, TD (2006) Dark adaptation of human rod bipolar cells measured from the b wave of the scotopic electroretinogram. Journal of Physiology 575(2): 507-526.
Carr, PD, Conlan, F, Ford, S, Ollis, DL, and Young, IG (2006) An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. Acta Crystallographica. Section F- structural biology and crystallization communications. 62(6): 509-513.
Casarotto, MG, Cui, YF, Karunasekara, Y, Harvey, PJ, Norris, N, Board, PG, and Dulhunty, AF (2006) Structural and functional characterization of interactions between the dihydropyridine receptor II-III loop and the ryanodine receptor. Clinical and Experimental Pharmacology and Physiology 33(11): 1114-1117.
Chaudhri, G, Panchanathan, V, Bluethmann, H, and Karupiah, G (2006) Obligatory requirement for antibody in recovery from a primary poxvirus infection. Journal of Virology 80(17): 8844.
Clark, IA, Budd, AC, Alleva, LM, and Cowden, WB (2006) Human malarial disease: a consequence of inflammatory cytokine release. Malaria Journal 5: 85-85.
Cook, MC, Vinuesa, CG, and Goodnow, CC (2006) ENU-mutagenesis: insight into immune function and pathology. Current Opinion in Immunology 18(5): 627-633.
Coupar, BEH, Purcell, DFJ, Thomson, SA, Ramshaw, IA, Kent, SJ, and Boyle, DB (2006) Fowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials. Vaccine 24(99): 1378-1388.
Dahlke, MH, Loi, R, Warren, A, Holz, L, Popp, FC, Weiss, DJ, Piso, P, Bowen, DG, McCaughan, GW, Schlitt, HJ, and Bertolino, P (2006) Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of Hepatology 44(2): 334-341.
Dale, CJ, Thomson, S, De Rose, R, Ranasinghe, C, Medveczky, CJ, Pamungkas, J, Boyle, DB, Ramshaw, IA, and Kent, SJ (2006) Prime-boost strategies in DNA vaccines. DNA Vaccines - Methods and Protocols. Ed. WM Saltzman, Totowa, New Jersey, USA: Humana Press Inc. pp. 171-198.
Davie, JT, Kole, MH, Letzkus, JJ, Rancz, EA, Spruston, N, Stuart, GJ, and Hausser, M (2006) Dendritic patch-clamp recording. Nature Protocols 1: 1235-1247.
De Rose, R, Sullivan, MT, Dale, CJ, Kelleher, AD, Emery, S, Cooper, DA, Ramshaw, IA, Boyle, D, and Kent, SJ (2006) Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials. Human Vaccines 2(3): 134-136.
Dixon, C, Christie, J, Milburn, P, Matthaei , KI, Foster, PS, and Webb, DC (2006) Proteomic analysis of bronchoalveolar lavage fluid from allergic mice reveals a potential therapeutic protein. 16th European Congress of Immunology. pp.
Dulhunty, AF (2006) Excitation-contraction coupling from the 1950s into the new millennium. Clinical and Experimental Pharmacology and Physiology 33(9): 763-772.
Dulhunty, AF, Beard, NA, Pouliquin, P, and Kimura, T (2006) Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies. Journal of Muscle Research and Cell Motility 27(5-7): 351-365.
Edwards, FR and Hirst, GDS (2006) An electrical analysis of slow wave propagation in the guinea-pig gastric antrum. Journal of Physiology-London 571: 179-189.
Faber, ESL, Sedlak, P, Vidovic, M, and Sah, P (2006) Synaptic activation of transient receptor potential channels by metabotropic glutamate receptors in the lateral amygdala. Neuroscience 137(3): 781-794.
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JCSMR Publications
Fang, YY, Kashkarov, U, Anders, MW, and Board, PG (2006) Polymorphisms in the human glutathione transferase zeta promoter. Pharmacogenetics and Genomics 16(4): 307-13.
Forbes, E, Hulett, M, Ahrens, R, Wagner, N, Smart, V, Matthaei, KI, Brandt, EB, Dent, LA, Rothenberg, ME, Tang, M, Foster, PS, and Hogan, SP (2006) ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. Journal of Leukocyte Biology 80(2): 330-341.
Franklin, A and Blanden, RV (2006) A/T-targeted somatic hypermutation: critique of the mainstream model. Trends in Biochemical Sciences 31(5): 252-258.
Gibbs, GM, Scanlon, MJ, Swarbrick, J, Curtis, S, Gallant, E, Dulhunty, AF, and O’Bryan, MK (2006) The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. Journal of Biological Chemistry 281(7): 4156-4163.
Goffin, L, Vodala, S, Fraser, C, Ryan, J, Timms, M, Meusburger, S, Catimel, B, Nice, EC, Silver, PA, Xiao, CY, Jans, DA, and Gething, MJH (2006) The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins. Molecular Biology of the Cell 17(12): 5309-5323.
Goodnow, CC (2006) Discriminating microbe from self suffers a double toll. Science 312(5780): 1606-1608.
Gopinath, B, Musselman, R, Adams, CL, Tani, J, Beard, N, and Wall, JR (2006) Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves’ disease with and without ophthalmopathy: Correlation with clinical features. Thyroid 16(10): 967-974.
Gopinath, B, Musselman, R, Beard, N, El-Kaissi, S, Tani, J, Adams, CL, and Wall, JR (2006) Antibodies targeting the calcium binding skeletal muscle protein calsequestrin are specific markers of ophthalmopathy and sensitive indicators of ocular myopathy in patients with Graves’ disease. Clinical and Experimental Immunology 145(1): 56-62.
Gray, DHD, Seach, N, Ueno, T, Milton, MK, Liston, A, Lew, AM, Goodnow, CC, and Boyd, RL (2006) Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108(12): 3777-3785.
Grayson, TH (2006) Is Cx40 a marker for hypertension? Journal of Hypertension 24(2): 279-280.
Gready, JE, Rostov, I and Cummins, PL (2006) Simulations of enzyme reaction mechanisms in active sites: accounting for an environment which is much more than a solvent perturbation. Modelling Molecular Structure and Reactivity in Biological Systems. eds. K.J. Naidoo, M. Hann, J. Gao, M. Field and J, Brady, Eds., Royal Society of Chemistry, London. pp. 101-118
Greaves, IK, Rangasamy, D, Devoy, M, Graves, JAM, and Tremethick, DJ (2006) The X and Y chromosomes assemble into H2A.Z, containing facultative heterochromatin, following meiosis. Molecular and Cellular Biology 26(19): 7343-7343.
Haddock, RE, Grayson, TH, Brackenbury, TD, Meaney, KR, Neylon, CB, Sandow, SL, and Hill, CE (2006) Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins 37 and 40. American Journal of Physiology - Heart and Circulatory Physiology. 291: H2047-H2056.
Halenius, A, Momburg, F, Reinhard, H, Bauer, D, Lobigs, M, and Hengel, H (2006) Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing (TAP). Journal of Biological Chemistry 281: 5383-5390.
Harrison, JM, Bertram, EM, Boyle, DB, Coupar, BEH, Ranasinghe, C, and Ramshaw, I (2006) 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine. Vaccine 24(47-48): 6867-6874.
Harrison, JM, Bertram, EM, and Ramshaw, IA (2006) Exploiting 4-1BB costimulation for enhancing antiviral vaccination. Viral Immunology 19(4): 593-601.
Harrison, JM and Ramshaw, IA (2006) Cytokines, skin, and smallpox - A new link to an antimicrobial peptide. Immunity 24(3): 245-247.
Hirst, GDS and Edwards, FR (2006) Electrical events underlying organized myogenic contractions of the guinea pig stomach. Journal of Physiology-London 576(3): 659-665.
Hirst, GDS, Garcia-Londono, AP, and Edwards, FR (2006) Propagation of slow waves in the guinea-pig gastric antrum. Journal of Physiology-London 571(1): 165-177.
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Publications 2006JCSMR Publications
Hirst, GDS and Suzuki, H (2006) Involvement of interstitial cells of Cajal in the control of smooth muscle excitability. Journal of Physiology-London 576(3): 651-652.
Ho, JW, Adams, CE, Lew, JB, Matthews, TJ, Ng, CC, Shahabi-Sirjani, A, Tan, LH, Zhao, Y, Easteal, S, Wilson, SR, and Jermiin, LS (2006) SeqVis: visualization of compositional heterogeneity in large alignments of nucleotides. Bioinformatics 22(17): 2162-2163.
Hoyne, GF and Goodnow, CC (2006) The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. Immunological Reviews 210: 27-39.
Hu, L, Zhang, Y, Lim, PS, Miao, Y, Tan, C, McKenzie, KUS, Schyvens, CG, and Whitworth, JA (2006) Apocynin but not l-Arginine prevents and reverses dexamethasone-induced hypertension in the rat. American Journal of Hypertension 19(4): 413-418.
Ikeda, K and Bekkers, JM (2006) Autapses. Current Biology 16(9): R308.
Jayasekera, JP, Vinuesa, CG, Karupiah, G, and King, NJC (2006) Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice. Journal of General Virology 87: 3361-3371.
Kampa, BM, Letzkus, JJ, and Stuart, GJ (2006) Requirement of dendritic calcium spikes for induction of spike-timing-dependent synaptic plasticity. Journal of Physiology 574(1): 283-290.
Kampa, BM, Letzkus, JJ, and Stuart, GJ (2006) Cortical feed-forward networks for binding different streams of sensory information. Nature Neuroscience 9(12): 1472-1473.
Kampa, BM and Stuart, GJ (2006) Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts. Journal of Neuroscience 26(28): 7424-32.
Kelleher, AD, Puls, RL, Bebbington, M, Boyle, D, Ffrench, R, Kent, SJ, Kippax, S, Purcell, DFJ, Thomson, S, Wand, H, Cooper, DA, and Emery, S (2006) A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1. AIDS Research and Human Retroviruses 20(2): 294-297.
Kennedy, CL, O’Connor, AEO, Sanchez-Partida, LG, Holland, MK, Goodnow, CC, de Kretser, DM, and O’Bryan, MK (2006) A repository of ENU mutant mouse lines and their potential for male fertility research. Molecular Human Reproduction 11(12): 871-880.
Kole, MH, Hallermann, S, and Stuart, GJ (2006) Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output. Journal of Neuroscience 26(6): 1677-87.
Kumar, RK, Webb, DC, Herbert, C, and Foster, PS (2006) Interferon-gamma as a Possible Target in Chronic Asthma. Inflammation and Allergy Drug Targets 5(4): 253-6.
Lamb, TD and Pugh, EN Jr (2006) Phototransduction, dark adaptation, and rhodopsin regeneration - The Proctor Lecture. Investigative Ophthalmology and Visual Science 47(12): 5138-5152.
Leao, KE, Leao, RN, Sun, H, Fyffe, REW, and Walmsley, B (2006) Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei. Journal of Physiology 576(3): 849-864.
Leao, RN, Naves, MM, Leao, KE, and Walmsley, B (2006) Altered sodium currents in auditory neurons of congenitally deaf mice. European Journal of Neuroscience 24(4): 1137-1146.
Leao, RN, Sun, H, Svahn, K, Berntson, A, Youssoufian, M, Paolini, AG, Fyffe, REW, and Walmsley, B (2006) Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness. Journal of Physiology 571(3): 563-78.
Leck, KJ, Blaha, CD, Matthaei, KI, Forster, GL, Holgate, J, and Hendry, IA (2006) G(z) proteins are functionally coupled to dopamine D2-like receptors in vivo. Neuropharmacology 51(3): 597-605.
Lee, E, Pavy, M, Young, N, Freeman, C, and Lobigs, M (2006) Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses. Antiviral Research 69(31-38).
Lee, E, Wright, PJ, Davidson, A, and Lobigs, M (2006) Virulence attenuation of Dengue virus due to augmented glycosaminoglycan-binding affinity and restriction in extraneural dissemination. Journal of General Virology 87: 2791-2801.
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Letzkus, JJ, Kampa, BM, and Stuart, GJ (2006) Learning rules for spike timing-dependent plasticity depend on dendritic synapse location. Journal of Neuroscience 26(41): 10420-10429.
Linares, D, Taconis, M, Mana, P, Correcha, M, Fordham, S, Staykova, M, and Willenborg, DO (2006) Neuronal nitric oxide synthase plays a key role in CNS demyelination. Journal of Neuroscience 26(49): 12672-12681.
Liu, SM, Xavier, R, Good, KL, Chtanova, T, Newton, R, Sisavanh, M, Zimmer, S, Deng, CY, Silva, DG, Frost, MJ, Tangye, SG, Rolph, MS, and Mackay, CR (2006) Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes. Journal of Allergy and Clinical Immunology 118(2): 496-503.
Liu, WJ, Wang, XJ, Clark, DC, Lobigs, M, Hall, RA, and Khromykh, AA (2006) A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit interferon alpha/beta induction and attenuates virus virulence in mice. Journal of Virology 80: 2396-2404.
Luu, T, Gage, PW, and Tierney, ML (2006) GABA increases both the conductance and mean open time of recombinant GABAA channels co-expressed with GABARAP. Journal of Biological Chemistry 281(47): 35699-35708.
Maddess, T, James, AC, Ruseckaite, R, and Bowman, EA (2006) Hierarchical decomposition of dichoptic multifocal visual evoked potentials. Visual Neuroscience 23(5): 703-712.
Manderson, AP, Quah, B, Botto, M, Goodnow, CC, Walport, MJ, and Parish, CR (2006) A novel mechanism for complement activation at the surface of B cells following antigen binding. Journal of Immunology 177(8): 5155-5162.
Mangos, GJ, Walker, BR, Williamson, PA, Whitworth, JA, and Kelly, JJ (2006) Effect of synthetic corticosteroids on vascular reactivity in the human forearm. Clinical and Experimental Hypertension 28(8): 707-718.
May, F, Lobigs, M, Lee, E, Gendle, Mackenzie, JS, Broom, AK, Conlan, JV, and Hall, RA (2006) Biological, antigenic and phylogenetic characterisation of the flavivirus Alfuy. Journal of General Virology 87: 329-337.
McColl, CD, Jacoby, AS, Shine, J, Iismaa, TP, and Bekkers, JM (2006) Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus. Neuropharmacology 50(2): 209-218.
Mondo, CK, Zhang, Y, Possamai, VD, Miao, YC, Schyvens, CG, McKenzie, KUS, Hu, LX, Guo, ZJ, and Whitworth, JA (2006) N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat. Clinical and Experimental Hypertension 28(2): 73-84.
Mullbacher, A, Lobigs, M, Alsharifi, M, and Regner, M (2006) Cytotoxic T-cell immunity as a target for influenza vaccines. Lancet Infectious Diseases 6(5): 255-256.
Murphy, JM and Young, IG (2006) IL-3, IL-5, and GM-CSF signalling: Crystal structure of the human beta-common receptor. Interleukins. ed. G Litwack. Elsevier Academic Press Inc. Vol 74:1-32.
Ng, CH, Easteal, S, Tan, S, Schweitzer, I, Ho, BKW, and Aziz, S (2006) Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities. Progress in Neuro-psychopharmacology and Biological Psychiatry 30(5): 953-957.
Nijnik, A, Ferry, H, Lewis, G, Rapsomaniki, E, Leung, JCH, Daser, A, Lambe, T, Goodnow, CC, and Cornall, RJ (2006) Spontaneous B cell hyperactivity in autoimmune-prone MRL mice. International Immunology 18(7): 1127-1137.
Palmer, LM and Stuart, GJ (2006) Site of action potential initiation in layer 5 pyramidal neurons. Journal of Neuroscience 26(6): 1854-63.
Panchanathan, V, Chaudhri, G, and Karupiah, G (2006) Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. Journal of Virology 80(13): 63333-6338.
Pardo, J, Urban, C, Galvez, EM, Ekert, PG, Muller, U, Kwon-Chung, J, Lobigs, M, Mullbacher, A, Wallich, R, Borner, C, and Simon, MM (2006) The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. The Journal of Cell Biology 174(4): 509-519.
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Publications 2006JCSMR Publications
Parish, CR (2006) The role of heparan sulphate in inflammation. Nature Reviews Immunology 6(9): 633-643.
Patterson J, Chandrasekara, A, Bao, S, Hegedus, E, Caterson, I, Denyer G, Turner, B, Mullbacher, A and Chin, J (2006) Prebiotic supplementation with resistant starch alters health indices associated with metabolic changes and intestinal dysbiosis. International Journal of Probiotics and Prebiotics 1:181-192.
Pouliquin, P, Pace, SM, Curtis, SM, Harvey, PJ, Gallant, EM, Zorzato, F, Casarotto, MG, and Dulhunty, AE (2006) Effects of an alpha-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: Modulation by Homer. International Journal of Biochemistry and Cell Biology 38(10): 1700-1715.
Premkumar, A, Dong, XB, Haqshenas, G, Gage, PW, and Gowans, EJ (2006) Amantadine inhibits the function of an ion channel encoded by GB virus B, but fails to inhibit virus replication. Antiviral Therapy 11(3): 289-295.
Prescott, VE, Forbes, E, Foster, PS, Matthaei, K, and Hogan, SP (2006) Mechanistic analysis of experimental food allergen-induced cutaneous reactions. Journal of Leukocyte Biology 80(2): 258-266.
Prescott, VE and Hogan, SP (2006) Genetically modified plants and food hypersensitivity diseases: Usage and implications of experimental models for risk assessment. Pharmacology and Therapeutics 111(2): 374-383.
Prichard, Z and Easteal, S (2006) Characterization of simple sequence repeat variants linked to candidate genes for behavioral phenotypes. Human Mutation 27(1): 120.
Ranasinghe, C, Medveczky, JC, Woltring, D, Gao, K, Thomson, S, Coupar, BEH, Boyle, DB, Ramsay, AJ, and Ramshaw, IA (2006) Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1. Vaccine 24(31-32): 5881-5895.
Rao, S, Bunting, K, Sutcliffe, EL, and Shannon, F (2006) Deciphering regulatory networks controlled by the NF-kB transcription factor c-Rel in T cells. Microarrays and Transcription Networks, eds. MF Shannon and S Rao. Landes Bioscience, Georgetown, Texas. pp. 75-89.
Raymond, CR and Redman, SJ (2006) Spatial segregation of neuronal calcium signals encodes different forms of LTP in rat hippocampus. Journal of Physiology-London 570(1): 97-111.
Rolph, M, S, Young, T, R, Shum, BOV, Gorgun, CZ, Schmitz-Peiffer, C, Ramshaw, IA, Hotamisligil, GS, and Mackay, CR (2006) Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein aP2. Journal of Immunology 177(11): 7794-7801.
Rui, LX and Goodnow, CC (2006) Lymphoma and the control of B cell growth and differentiation. Current Molecular Medicine 6(3): 291-308.
Rui, LX, Healy, JI, Blasioli, J, and Goodnow, CC (2006) ERK signalling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-Driven plasma cell differentiation. Journal of Immunology 177(8): 5337-5346.
Rummery, N and Hill, C, (2006) The Role of Gap Junctions in the Regulation of Arteriolar Tone. Microvascular Research: Biology and Pathology. ed. D Shepro. Elsevier BV. Vol1: pp. 275-280.
Ruseckaite, R, Maddess, T, Danta, G, and James, AC (2007) Frequency doubling illusion VEPs and automated perimetry in multiple sclerosis. Documenta Ophthalmologica 113(1): 29-41.
Ryu, KY, Baker, RT, and Kopito, RR (2006) Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimens. Analytical Biochemistry 353(1): 153-5.
Schofield, PW, Gibson, R, Tavener, M, Attia, R, D’Este C, Guest, M, Brown, AM, Lee, SJ, Horsley, K, Harrex, W, and Ross, J (2006) Neurophysiological health in F-111 aircraft maintenance workers. (Schofield, P W on behalf of the SHOAMP study team and scientific advisory committee, Chair: JA Whitworth) Neurotoxicology 27(5): 852-60.
Shannon, MF, Chen, X, Brettingham-Moore, K, and Holloway, A (2006) Chromatin remodelling: Distinct molecular events during differentiation and activation of T cells. Current Immunology Reviews 2: 273-289.
Sharkhuu, T, Matthaei, K, Forbes, E, Mahalingam, S, Hogan, SP, Hansbro, PM, and Foster, PS (2006) Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity. Clinical and Experimental Allergy 36:1575-1583.
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JCSMR Publications
Shield, AJ, Murray, TP, and Board, PG (2006) Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase. Biochemical and Biophysical Research Communications 347(4): 859-866.
Siegle, JS, Hansbro, N, Herbert, C, Yang, M, Foster, PS, and Kumar, RK (2006) Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation. American Journal of Respiratory Cell and Molecular Biology 35(5): 565-570.
Siggs, OM, Makaroff, LE, and Liston, A (2006) The why and how of thymocyte negative selection. Current Opinion in Immunology 18(2): 175-83.
Socha, LA, Gowardman, J, Silva, D, Correcha, M, and Petrosky, N (2006) Elevation in interleukin 13 levels in patients diagnosed with systemic inflammatory response syndrome. Intensive Care Medicine 32(2): 244-250.
Song, ZM, Hu, J, Rudy, B, and Redman, SJ (2006) Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells. Neuroscience 141(1): 543-543.
Staykova, M, Fordham, S, Bartell, G, Cowden, W, and Willenborg, D (2006) Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 176(1-2): 1-8.
Strumbo, B, Sangiorgio, L, Ronchi, S, Gready, J, and Simonic, T (2006) Cloning and analysis of transcripts and genes encoding fish-specific proteins related to PrP. Fish Physiology and Biochemistry 32(4): 339-353.
Stuart, G and Palmer, L (2006) Imaging membrane potential in dendrites and axons of single neurons. Pflugers Archiv-Euopean Journal of Physiology 453(3): 403-410.
Suzuki, N and Bekkers, JM (2006) Neural coding by two classes of principal cells in the mouse piriform cortex. Journal of Neuroscience 26(46): 1 1938-11947.
Swartz, JM, Dyer, KD, Cheever, AW, Ramalingam, T, Pesnicak, L, Domachowske, JB, Lee, JJ, Lee, NA, Foster, PS, Wynn, TA, and Rosenberg, HF (2006) Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood 108(7): 2420-2427.
Tremethick, D (2006) Chromatin: the dynamic link between structure and function. Chromosome Research 14(1): 1-4.
Tscharke, DC, Woo, W-P, Sakala, IG, Sidney, J, Sette, A, Moss, DJ, Bennick, JR, Karupiah, G, and Yewdell, JW (2006) Poxvirus CD8+ T-Cell Determinants and Cross-Reactivity in BALB/c Mice. Journal of Virology 80(13): 6318-6323.
van Hateren, JH and Lamb, TD (2006) The photocurrent response of human cones is fast and monophasic. BMC Neuroscience 7(34).
Wakefield, MJ and Alsop, AE (2006) Assignment of breast cancer associated 1 (BRCA1) to tammar wallaby (Macropus eugenii) chromosome 2q3 in situ hybridization. Cytogenetic and Genome Research 112:180C.
Walker, EJ, Riddell, J, Rodgers, HJ, Bassett, ML, Wilson, SR, and Cavanaugh, JA (2006) IL1RN genotype as a risk factor for joint pain in hereditary haemochromatosis? Annals of the Rheumatic Diseases 65(2): 271-272.
Walmsley, B, Berntson, A, Leao, RN, and Fyffe, REW (2006) Activity-dependent regulation of synaptic strength and neuronal excitability in central auditory pathways. Journal of Physiology 572(2): 313-321.
Wang, J, Shannon, MF, and Young, IG (2006) A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th-2 lymphocytes. International Immunology 18(20): 313-323.
Wang, Y, Lobigs, M, Lee, E, Koskinen, A, and Mullbacher, A (2006) CD8+ T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon. Journal of General Virology 87: 3599-3609.
Warren, HS, Rana, PM, Rieger, DT, Hewitt, KA, Dahlstrom, JE, and Kent, AL (2006) CD8 T cells expressing killer Ig-like receptors and NKG2A are present in cord blood and express a more naive phenotype than their counterparts in adult blood. Journal of Leukocyte Biology 79: 1252-1259.
Wei, L, Varsanyi, M, Dulhunty, AF, and Beard, NA (2006) The conformation of calsequestrin determines its ability to regulate skeletal ryanodine receptors. Biophysical Journal 91(4): 1288-1301.
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Publications 2006
Whitworth, JA (2006) Best practices in use of research evidence to inform health decisions. Health Research Policy and Systems 4:11
Whitworth, JA, Zhang, Y, Mangos, G, and Kelly, JJ (2006) Species variability in cardiovascular research: The example of adrenocorticotrophin-induced hypertension. Clinical and Experimental Pharmacology and Physiology 33(9): 887-891.
Wilson, L, Gage, P, and Ewart, G (2006) Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology 353(2): 294-306.
Wilson, L, Gage, P, and Ewart, G, 2006, Validation of coronavirus e proteins ion channels as targets for antiviral drugs. The Nidoviruses: Toward Control of SARS and other Nidovirus Diseases, eds. S Perlman and KV Holmes. Springer. pp 573-578.
Yang, M, Rangasamy, D, Matthaei, KI, Frew, AJ, Zimmmermann, N, Mahalingam, S, Webb, DC, Tremethick, DJ, Thompson, PJ, Hogan, SP, Rothenberg, ME, Cowden, WB, and Foster, PS (2006) Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. Journal of Immunology 177(8): 5595-5603.
Yang, TZ, Riehl, J, Esteve, E, Matthaei, KI, Goth, S, Allen, PD, Pessah, IN, and Lopez, JR (2006) Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology 105(6): 1164-1175.
Zaunders, JJ, Dyer, WB, Munier, ML, Ip, S, Liu, J, Amyes, E, Rawlinson, W, De Rose, R, Kent, SJ, Sullivan, JS, Cooper, DA, and Kelleher, AD (2006) CD127+CCR5+CD38+++CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cells. Journal of Virology 80(20): 10151-10161.
Zhang, JH, Kawashima, S, Yokoyama, M, Huang, P, and Hill, CE (2006) Increased eNOS accounts for changes in connexin expression in renal arterioles during diabetes. The Anatomical Record Part A- Discoveries in Molecular Cellular and Evolutionary Biology 288A(9): 1000-1008.
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TheJohnCurtinSchoolofMedicalResearchiscommittedto
maintainingcontactwithourpaststaffandstudentsthrough
ourAlumniandFriendsnetwork.Westrivetostrengthenour
tieswithourlocalCanberracommunitythroughvisitsand
speakingengagements.
Forinformationaboutjoiningthisgrowingnetworkoffriends
andsupporters,pleasecontactourPublicAffairsManager:
Dr Madeleine Nicol E:[email protected]
T:+61261252577 F:+61261252337
Our Community
The John Curtin School of Medical Research Annual Review 2006
��
Com
mun
ity
Cont
act
2006
New facility takes major step in cancer fightMrTomDery,ChairmanofTheAustralian
CancerResearchFoundation(ARCF),with
ProfessorFrancesShannon,ProfessorJudith
WhitworthandProfessorIanChubbatthe
officialopeningoftheACRFBiomolecular
ResourceFacilitylocatedinthenewJohn
CurtinSchoolofMedicalResearchbuilding.
TheACRFhasdonated$1.3Mtowardsset
upandequipmentforthisfacility.Thiswill
provideamuchneededresourcetoscientists
carryingoutresearchintocancerinthe
ACTregion.
Our Community 2006
Opening of the Finkel Lecture TheatreDrsAlanandElizabethFinkelofficiallyopenedtheFinkelLectureTheatreinthenewJCSMRbuildingduringOctober.
DrAlanFinkel,neuroscientistandentrepreneurhaslongbeenassociatedwithJCSMR,sincehispostdoctoralfellowship
inneuroscienceintheearly1980’s.DrElizabethFinkelisanotedsciencecommunicator.Theeventwasalsoattendedby
MrsVeraFinkel,andAlexFinkel.
Nobel Laureate visits JCSMRNobelLaureateEmeritusProfessorJRobin
WarrenvisitedTheJohnCurtinSchoolof
MedicalResearchtospeakinformallywith
studentsatafternoontea.ProfessorWarren,
picturedwithMaryWarren,wasawarded
TheNobelPrizeinPhysiologyorMedicine
2005conjointlywithProfessorBarry
Marshallfor“theirdiscoveryofthebacterium
‘Helicobacterpylori’anditsroleingastritis
andpepticulcerdisease”.
phot
oby
Stu
artH
ay
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Comm
unity Contact 2006
Contact with our Community
Telstra Businesswomen’s Breakfast at JCSMRProfessor Judith Whitworth hosted the Telstra Businesswomen’s network breakfast in the new Board Room in September.
Drs Carola de Vinuesa, Luby Simson, Anneke Blackburn and Monique Youssoufian discussed the expected outcomes of their research.
JCSMR RetreatStaff and students of the JCSMR attended a one day scientific Retreat ‘At Home’ this year, hearing presentations about research and future plans for all areas of the school. As part of the day, staff and students were invited to be a part of an all-school photo, celebrating the move into Stage 1 of our new building.
The Hon. Tony Abbot and JDRF representative Lara sign the card • Mr Robert de Castella, Lara, and The Hon. Tony Abbott • Professor Warwick Anderson (Chief Executive Office National Health & Medical Research Council) Mr Robert de Castella, Ms Rebecca James (Chief Executive Officer Research Australia) and The Hon. Tony Abbott cut a cake at the Research Australia Thank You day celebrations.
Thank You DayResearch Australia hosted the Canberra launch of the 4th Annual Thank You Day celebrations in the JCSMR foyer during October. The Thank You Day card was signed by sporting personalities, medical researchers and health consumers from the Canberra region, including Mr Robert de Castella, former marathon champion. The Federal Minister for Health and Ageing, The Hon. Tony Abbott attended the launch.
Town & GownTown and Gown Christmas
drinks were held at The
John Curtin School of
Medical Research early
in December. The annual
Town and Gown event
celebrates successful
research and endeavour
by bringing together
members of the University
and business communities
from Canberra and the
surrounding region.
Top: Ms Mary-Anne Waldren (Executive Director, Australian Science Festival Ltd) and Dr Susan Stocklmayer (Director, Centre for the Public Awareness of Science, ANU) at the JCSMR Town and Gown event.
Bottom: Professor Helen Christensen (Director Centre for Mental Health Research, ANU) The Hon. Margaret Reid and Mr Robert Wells (Executive Director, ANU College of Medicine and Health Sciences) attend the JCSMR Town and Gown event.
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Com
mun
ity
Cont
act
2006
Join us on Open Day 2007Bookings essential for school groups only
Please contact Dr Madeleine Nicol on
T: 6125 2577 or
Open Day 2006
NextOpenDayFriday17August2007,10am–5pm
OnOpenDay,theSchoolisopentoallmembersofthepublic.•Studentsinterestedinmedicalresearchareparticularlyinvited
toattend.•Researchersinfieldsasdiverseasasthma,diabetes,hearing,HIVandcanceropenthedoorsoftheirlaboratoriesto
demonstratetheirworkandanswerquestions.
TheSchoolisopenduringNationalScienceWeekaspartoftheAustralianScienceFestival.•TheJohnCurtinSchoolofMedicalResearchannualOpenDaygivesyoutheopportunitytotalktoscientistsintheirworkinglaboratories.
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Voluntary Service 2006
Commitment to Serving our Community
StaffandstudentsoftheJCSMRareinvolvedinmanyactivitieswhichrelatetotheirresearchbutextendbeyondtheirlaboratorywork.
Inadditiontotheactivitieslistedbelow,JCSMRstaffandstudentsspeakwithcommunitygroupsandinterestedmembersofthepublicthroughsuchactivitiesasNationalYouthScienceForumandJCSMROpenDay,actasrefereesformanyscientificpublicationsandactasexpertassessorsforawiderangeofnationalandinternationalgrantingbodies.
Someothervoluntaryactivitiesarelistedbelow.
Professor GL AdaMember: Australian Influenza Vaccine CommitteeScientific Patron: Burnet Institute, Melbourne, VICPresenter and Participant: National Youth Science Forum at JCSMR, Canberra, ACTCourse Presenter: ACT Senior Colleges: The Importance of Vaccination
Dr RT BakerPresident and Executive Director: Genome Conference IncExecutive Council Member and Honorary Secretary: The Australian Society for Biochemistry andMolecular BiologyExpert Consultant: Human Gene Nomenclature Committee, LondonOrganising Committee Member: International Congress on Yeast Genetics and Molecular Biology,Melbourne, VIC (2007)
Dr JM BekkersDirector and Board Member: The Australian Advanced Neuroscience Research Initiative (AANRI), Moreton Bay Research Station, Stradbroke Island, QLDPanel Member: NHMRC - Neuroscience
Dr EM BertramTreasurer: Australasian Society of Immunology - ACT Branch
Dr A BlackburnCoordinator and Chair: Cancer Biology Workshop, JCSMR, Canberra, ACT
Professor PG BoardMember: Pharmaceutical subcommittee of Australian Drug Evaluation CommitteeAdvisor: Parkinson’s NSW Inc
Dr A CowanInstructor and presenter: The Australian Advanced Neuroscience Research Initiative (AANRI), MoretonBay Research Station, Stradbroke Island, QLD
Professor AF DulhuntyMember: International Union of Physiological Sciences (IUPS) Commission VI: Molecular and Cellular PhysiologyBoard of Directors: ACT Orthopaedic FoundationVice President and President Elect: Australian Society for BiophysicsPanel Member: NHMRC - Molecular Neuroscience
Professor S EastealHead: Research Committee, JDRLegal Pty LtdAdvisory Board: ARC Bioinformatics Centre of Excellence, The University of Queensland, Brisbane, QLD
Dr C FreemanACT convenor: Australian Society for Medical Research (ASMR)Forum Planning Committee Member: ASMR Young Investigator Advisor: ACT cancer website: http://www.hotkey.net.au/~string/listingACT representative: Matrix Biology Society of Australia and New Zealand
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Volu
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06
Voluntary Service to Organisations Outside JCSMR
Professor CC GoodnowDeputy Chair: NHMRC Project Grants Review Panel 2aScientific Advisory Committee: Australian Genome Research FacilityMember: Australian Academy of Science, Chair of Sectional CommitteeMember: Australian Academy of Science Special Elections CommitteeMedical Science Review Board Member, Juvenile Diabetes Research FoundationCommunicating Editor: International ImmunologyMember: Infection and Immunity Strategic Advisory Committee, The Wellcome Trust, UKEditorial Board member: Immunity, The Journal of Experimental Medicine, Mammalian Genome, Genome Biology, Journal of Autoimmunity, BMC BiologyMember: Australian Society of ImmunologyMember: American Association of ImmunologistsMember: American Association for the Advancement of Science
Professor JE GreadyConvenor: Australian Society for Biochemistry and Molecular Biology Bioinformatics Special InterestGroupSpecialist Editor: Computer Physics Communications (Biophysics)Advisory Board Member: APAC Grid Program “Grid Resource Management System for Computational Molecular Science Applications”Scientific Adviser: Impact of the proposed Mary River on the survival of Australian lungfish
Professor IA HendryScience Advisor: Board of the Wenkart Foundation
Professor CE HillPanel Member: NHMRC - NeuroscienceACT Representative: ANZ Microcirculation Society
Dr M HulettNational Executive Director: Australian Society for Medical Research (until November)President-Elect and Honorary Treasurer: The Australian Society for Medical Research (from November)Mentor: ANU Distinguished Scholars ProgramPresenter and Participant: National Youth Science Forum at JCSMR, Canberra, ACTPresenter: Australian Medical Students Association Leadership Forum
Dr G HuttleyProgram committee member: Asia Pacific Bioinformatics Consortium
Dr G KarupiahACT Councillor: The Australasian Society for Immunology IncCouncillor: The Federation of Immunological Societies of Asia-Oceania
Professor TD LambAdvisory Editor: Journal of General Physiology
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Voluntary Service to Organisations Outside JCSMR
Voluntary Service 2006
Dr KI MatthaeiConsultant: Australian Quarantine Inspection Service. Member: Stem Cell Ethics Australia Advisory Committee. Panel Member: NHMRC - InflammationMember: ANU Equity Diversity Consultative GroupMember: ANU Institutional Recombinant DNA Biosafety CommitteeAffiliate Member: Centre for the Molecular Genetics of DevelopmentMember: ARC Centre for Network in Genes and Environment in Development
Professor C ParishEditor-in-Chief: Immunology and Cell BiologyMedical Research Advisory Committee Member: The Australian Cancer Research FoundationANU representative: Program Management Committee of the Australian HIV Vaccine ConsortiumCouncil Member: The International Union of Immunological Societies (IUIS)
Professor IA RamshawScientific Advisory Panel Member: Westmead Institute for Cancer Research
Professor SJ RedmanTreasurer: International Brain Research OrganizationBoard Member: Neurosciences Australia LtdResearch Advisory Board Member: Prince of Wales Medical Research InstituteDirector: The Australian Advanced Neuroscience Research Initiative (AANRI), Moreton Bay ResearchStation, Stradbroke Island, QLDMember: NHMRC Program Grants Committee
Professor MF ShannonEditor: FEBS Letters (The Journal of the Federation of European Biochemical Societies)ACT Council Representative: Australian Society for Biochemistry and Molecular BiologyManagement Committee Member: Centre for Vascular Research, The University of New South Wales, Sydney, NSWBoard Member: Lorne Genome Inc
Associate Professor C StrickerInstructor and presenter: The Australian Advanced Neuroscience Research Initiative (AANRI), MoretonBay Research Station, Stradbroke Island, QLD
Dr GJ StuartInstructor and presenter: The Australian Advanced Neuroscience Research Initiative (AANRI), MoretonBay Research Station, Stradbroke Island, QLDChair: ACT “Brain Bee” committeeEditor: Journal of Physiology (London)
Dr ML TierneyOrganising Committee Member: Joint Australian Physiological Society & Australian Society for Biophysics
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Dr DJ TremethickInvited analyst: ChemtractBoard Member: Lorne Genome Inc.ACT representative: Australian Society for Medical Research
Dr CG VinuesaAssociate Editor: News and Commentary, Immunology and Cell BiologyMember: Australasian Society of Immunology
Dr HS WarrenCareer Development Award Committee Member: National Health and Medical Research Council of Australia
Professor JA WhitworthPatron: TADACT, Technical Aid to the Disabled ACTPatron: Wesley Institute, QLDHonorary Ambassador for WomenAmbassador for CanberraTrustee: High Blood Pressure Research Council of AustraliaDirector: Research AustraliaBoard Member: Menzies Research InstituteChair: Research and Development Advisory Committee, The George Institute, Sydney, NSWMember: National Health and Medical Research CouncilChair: Global Advisory Committee on Health Research, WHOMember: WHO Expert Advisory Panel on Health Science and Technology PolicyMember: WHO/ISH Liaison CommitteeMember: ISH International Scientific Program CommitteeWriting Committee Co-Chair: WHO/ISH GuidelinesChair: Selection Panel for the Commonwealth Health Minister’s Award for Excellence in Health andMedical ResearchDirector: Australian Science Festival Ltd (ASF)Ambassador: Heart Foundation (ACT Division)Member: The General Sir John Monash Awards Selection Committee
Professor IG YoungMember: Biological Defence Advisory Committee, (Department of Defence)Member: Awards Committee - Australian Society for Biochemistry and Molecular Biology
Voluntary Service to Organisations Outside JCSMR
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Support to the School 2006
• Grants
• Statistics
• Donors
The John Curtin School of Medical Research Annual Review 2006
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Gra
mts
200
5 Grants 2006
ACT Knowledge Fund GrantDr E Bertram, Dr M C Cook, Dr K Nelms and Dr J CherringtonA new approach for the rapid discovery and validation of target genes for drug development$200,000
ANU Major Equipment GrantDr JM Bekkers, Dr G Stuart, Professor B Walmsley, Dr C Raymond and Dr C StrickerPulsed long-wavelength laser for two photon microscopy$192,000Professor CE Hill, Professor AF Dulhunty, Professor B Walmsley, Professor PG Board, Professor C Parish, Dr M Hulett , Dr RT Baker, Professor I Hendry, Dr G Karupiah, Dr ML Tierney and Dr KI MatthaeiHigh resolution digital camera for ultrastructural
studies of biological systems$116,640
Australian Research Council Centre of ExcellenceProfessor P Gresshoff, Professor C Beveridge, Dr B Carroll, Professor B Rolfe, Professor C Parish, Dr M Djordjevic, Dr G Weiller, Dr U Mathesius, Dr R Rose,Professor M Singh and Dr P BhallaIntegrative Legume Research$2,000,000
Australian Research Council Centre of Excellence in Vision ScienceProfessor TD LambResearch Director$2,200,000
Australian Research Council Discovery GrantsDr RT BakerRole of a novel zinc-binding motif in the structure-function of deubiquitinating enzymes$75,000Professor PG Board and Dr M CasarottoCellular uptake of glutathione transferases and their development as cell transfection agents$90,000
Professor AF Dulhunty, Dr DR Laver and Dr MG CasarottoIntrinsic properties of the pore forming domain of the ryanodine receptor calcium channel$105,000Professor S Easteal, Dr R Trent, Dr K North, Dr B Yu, Dr J Gulbin, Dr AG Hahn and Dr N YangIdentifying genes that modify athletic performance$75,000Professor S Easteal, Dr GA Huttley, Dr AV Isaev and Dr MJ WakefieldAdaptive evolution of BRCA1 in ancestral mammals$75,000Professor JE Gready and Dr PL CumminsImportance of conformational and electrostatic contributions in simulations of enzyme reaction mechanisms$93,300Professor CE HillInvolvement of cell coupling in vascular function: Development of a computational modelTotal $105,000Professor T Pogge and Professor JA WhitworthJust rules for incentivising pharmaceutical research for disseminating its benefits.$116,000Professor MF Shannon and Dr P GeorgelNew models for the role of chromatin in controlling inducible gene expression$105,000Dr D TremethickThe Dynamic Control of Chromatin Structure$90,000
Australian Research Council Federation FellowshipProfessor C GoodnowDiscovering genes and mechanisms regulating immune responses$158,111Professor TD LambThe first stage of vision: Transduction and adaptation in retinal photoreceptors$300,000
The amounts shown are for the calendar year 2006
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Grants 2006
Grants
Australian Research Council Linkage GrantsDr MG CasarottoMolecular Interactions of chemical agents with ion channel proteins$70,000Professor AF DulhuntyRefinement and delivery of synthetic compounds that specifically alter muscle contraction$50,000Professor AF Dulhunty, Dr CJ Easton and Dr MG CasarottoSynthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels$45,000Professor JE Gready and Professor G OttingWhy is the photosynthetic CO2-fixing enzyme, Rubisco, so inefficient? Dissection of the catalytic chemistry by computational simulation and experimental testing$215,000Dr GA Huttley, Dr A Isaev and Cray Australia P/LNovel bioinformatics approaches for biological inference from comparative genomics data$30,000
The Canberra Hospital Private Practice FundDr HS Warren and Dr D KnightCharacterising a CD8ab Natural Killer cell subset enriched in cord blood$34,687
Diabetes AustraliaDr C Simeonovic, Professor C Parish, Dr P Milburn, Dr W Cowden, Clinical Associate Professor JD Wilson and Dr R RodgersThe role of matrix metalloproteinases in the development of destructive autoimmunity and clinical diabetes in NOD mice$45,000
European Commission GrantProfessor C GoodnowEURAPS: Autoimmune polyendocrine syndrome type 1 – a rare disorder of childhood as a model for autoimmunity EUR 15,000(Combined grant with National Health and Medical Research Council)
Howard Hughes Medical Institute, USADr G KarupiahImmune response to viral infection$50,000
Juvenile Diabetes Research FoundationProfessor C GoodnowMolecular analysis of pathways in diabetes$660,000Professor C Goodnow and Dr GF HoyneIdentifying genes that oppose type 1 diabetes$330,000Dr C Vinuesa and Dr Diego SilvaRoquin prevents autoimmune diabetes through a novel tolerance pathway$206,840
Multiple Sclerosis SocietyDr C Vinuesa, Dr D Silva and Dr D LinaresElucidating the role of the autoimmune modulator Roquin and follicular helper T cells in the prevention of experimental autoimmune encephalitis$55,000
National Health & Medical Research Council Capacity Building GrantProfessor T Dwyer, Dr G Jones, Dr A Venn, Dr L Blizzard, Professor S Easteal, Dr A-L Ponsonby and Professor P ZimmettBuilding Australia’s capacity to study preventable causes of common diseases through epidemiological research. $500,000
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mts
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5
Grants
National Health & Medical Research Council Equipment GrantProfessor S Easteal-70 C Freezer for storage of human DNA and tissue samples for genetic analysis.$11,000Professor C HillFunctional Studies of vascular reactivity in health and disease$21,530Associate Professor G Stuart, Professor B Walmsley, Dr JM Bekkers, Dr FR Edwards and Professor SJ RedmanIn vivo study of neuronal networksDr DJ TremethickFluorescence resonance energy transfer imaging and analysis system$42,710Dr D WebbBuxco System for measuring respiratory function$37,804
National Health & Medical Research Council Health Services Research Program GrantProfessor S Leeder, Associate Professor R Colagiuri, Dr J Gillespie, Professor Nicholas Glasgow, Dr Stephen Jan, Mr Robert Wells and Professor JA WhitworthOptimising prevention and Management and care for Australians with, or at risk of serious and continuing chronic illness$703,000
National Health & Medical Research Council Peter Doherty FellowshipsDr ER Amyes$67,250Dr BJ Quah$67,250Dr L Simson$67,250Dr LE Tze$67,250Dr D Webb$57,500
National Health & Medical Research Council Program GrantsProfessor AF Jorm, Professor H Christensen, Dr B Rodgers, Professor S Easteal, Dr K AnsteyEpidemiology of high prevalence mental disorders: Aetiology, course and public health intervention$1,500,000Professor PS Foster, Dr SP Hogan, Dr KI Matthaei, Dr PI Thompson and Professor IG YoungMolecular Mechanisms in the Regulation of Allergy and Inflammation$970,000Professor C Chesterman, Dr R Andrews, Dr M Berndt, Professor B Chong, Professor P Hogg, Dr M Hulett, Associate Professor L Khachigian and Professor C ParishVascular Biology$2,000,000Professor P Doherty, Professor IA Ramshaw, Professor D Cooper and Associate Professor S KentStudies of HIV-1 infection and vaccination$350,000
National Health & Medical Research Council Project GrantsDr JM BekkersSynaptic integration and plasticity in the rat piriform cortex$80,000Dr E BertramCostimulatory mechanisms for enhancing CD8 T cell responses during an acute respiratory infection$144,250Professor P Board, Dr RT Baker and Dr A OakleyInvestigation of the Omega class of glutathione transferases.$160,000Dr G Chaudhri and Dr G KarupiahCritical role of TNF in host-virus interactions and outcome of infection: Involvement of reverse signalling through mTNF$165,000Professor AF DulhuntyCharacteristics of splice variants of the skeletal muscle ryanodine receptor: implications for myotonic dystrophy $85,000
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Grants 2006
Grants
Professor C GoodnowGenetic and biochemical mechanisms dysregulating CD4 T cell tolerance$145,000Professor C GoodnowEURAPS: Autoimmune polyendocrine syndrome type 1 – a rare disorder of childhood as a model for autoimmunity$169,000 (Combined grant with European Commission)Professor C Goodnow and Dr C VinuesaDefining the immunoregulatory function of Roqin: a novel gene essential for preventing autoimmunity$270,250Professor C Goodnow, Dr C Vinuesa, Dr M Cook and Dr GA HuttleyTranslational study of the genetics of systemic autoimmunity based on mouse mutagenesis$110,600Professor IA HendryThe proteins associated with the neurotrophin retrograde transport signalling endosome$95,000Professor GDS Hirst and Dr FR EdwardsIntramuscular interstitial cells of Cajal; Channels and their modulation by calcium ions and neurotransmitters$171,000Dr GA Huttley and Professor S EastealExploiting sexual differences in germline biology to resole the causes of germline mutation.$105,000Dr G KarupiahRole of plasmacytoid dendritic cells and neutrophils in the generation of antiviral immunity$154,000Professor TD LambElectroretinogram recordings of human scotopic dark adaptation following intense bleaching exposures$75,750Professor TD Lamb, BA Patterson and FN ReinholzProperties of human cone photoreceptors measured using a scanning laser ophthalmoscope to illuminate and image the retina$135,800
Dr M Lobigs and Dr E LeeRole of cell surface glycosaminoglycans in flavivirus biology$161,974Professor A Müllbacher and Dr M RegnerRole of granzymes in innate immunity$175,000Dr SC Barry, Professor MF Shannon, Dr H Zola H and Dr R D’AndreaMolecular Identification of FoxP3 +ve regulatory T cells$472,750Professor MF ShannonThe role of NF-kB transcription factors in regulating T cell transcription networks.$175,500Dr GJ StuartDendritic mechanisms underlying synaptic plasticity$95,000Dr A Gulledge and Dr GJ StuartMechanisms and consequences of cholinergicsignaling in neocortical pyramidal neurons$84,750Dr D Tremethick and Professor D JansEngineered histones as DNA carriers with application in therapeutic$136,000Dr D Tremethick and Dr P RidgwayThe role of heterochromatin in regulating cellular proliferation and development $166,000 Dr Tremethick and Dr D RangasamyMechanisms that underpin chromosome stability$164,000Dr D Webb, Professor R Kumar and Dr MG CasarottoFunctional analysis of the Ym2 chitinase-like lectins in allergic airways disease$92,250
National Health & Medical Research Council R Douglas Wright Biomedical Career Development AwardDr A Blackburn$87,250
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Grants
National Health & Medical Research Council Senior Research FellowshipsDr G Karupiah$114,500Dr HS Warren$114,500
National Health & Medical Research Council Senior Principal Research FellowshipsProfessor GDS Hirst$144,250
National Health & Medical Research Council Urgent Research GrantsProfessor I Clark and Professor A MüllbacherScreening of anti-inflamatory compounds in influenza infections$238,000Professor A Müllbacher and Dr M LobigsGamma-ray inactivated influenza virus vaccine for cross-protective T cell immunity$240,000
National Institutes of Health, USAProfessor C GoodnowGenes for Tolerance and Immunity Consortium$718,553Professor REW Fyffe and Professor B WalmsleyIntegrative Mechanisms in the Central Nervous System$US80,000Drs D Tscharke, Dr G Karupiah and Dr R BullerCD8+ T cell responses in mouse models of smallpox vaccination and challenge$337,000
Viertel Senior Medical Research FellowshipDr MD HulettRegulators of cell invasion and angiogenesis$165,000
�9
Statistics 2006
Income
BaseAllocation $14,072,000
IGS,RTS,RIBG $4,438,000
Adjustments $427,000
OtherIncome $2,670,000
SpecialPurposeFunds(SPF) $9,424,000
TOTAL INCOME $31,031,000
Expenditure
StaffCosts $12,853,000
Scholarships $992,000
Equipment $1,378,000
Travel $470,000
ExpendableResearchMaterial(ERM) $2,216,000
Other $3,685,000
SpecialPurposeFunds(SPF) $9,424,000
TOTAL EXPENDITURE $31,018,000
Special Purpose Funds
GovernmentGrants $8,723,000
Other $701,000
TOTAL $9,424,000
Statistics 2006
Staff Numbers 2006 2005 2004
Academicstaff 91 95.9 96
GeneralStaff—administration,technical&support 195 219 212
Postgraduatestudents 88 84 76
In July 2006, a number of JCSMR administrative staff members were transferred into the newly formed ANU College of Medicine and Health Sciences Administration Group (CAG).
90
Don
ors
2006 Donors 2006
The Director, staff and students of The John Curtin School of Medical Research are extremely grateful for the continued generosity of our friends and donors.
Wewouldliketothankthefollowingdonorsfortheirgeneroussupportin2006
GAda
AustralianDefenceForceAcademy,UniversityCollege
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9�
Donors 2006
The John Curtin School of Medical Research Needs Your Support
GiftsandbequeststotheSchoolareusedtofundvitalresearchprojectsinareassuchasasthma,cancer,
diabetes,highbloodpressure,hearinglossandvision,aswellasprovidingscholarshipsandpurchasing
specialisedequipment.Yoursupportcanbeprovidedinanumberofwaysincludingagiftorbequestthat
mayassistinfundingaparticularareaofresearch,orascholarshiporprize.
IfyouwouldliketodiscussoptionsforsupportingTheJohnCurtinSchoolofMedicalResearch,please
contact:
DrMadeleineNicol
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Published in Australia by:
The John Curtin School of Medical Research
ANU College of Medicine and Health Sciences
The Australian National University
Editors: Madeleine Nicol and Frith Rayner
Design and Layout: Sue Henderson
Photography: Karen Edwards
Back cover photograph: Rohan Baker
The John Curtin School of Medical Research
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Building 131, Garran RoadActon ACT 0200
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T: +61 2 6125 2550F: +61 2 6125 2337
W: jcsmr.anu.edu.auhttp://annualreport.jcs.anu.edu.au/2006/
The John Curtin School of Medical Research
Annual Review 2006