malariaThe integrated

Program

Merck KGaADarmstadt, Germany

MALARIA REMAINS A MAJOR GLOBAL HEALTH CHALLENGE IN ENDEMIC COUNTRIES

There is worldwide recognition that Malaria control requires integrated strategies

*According to WHO latest figures of December 2016

Nearly half of world population at risk of malaria

212 milion infections in 2015

429,000 deaths from malaria in 2015

About 70% of deaths are children <5 years

About 92% of deaths in Africa

MALARIA REMAINS A MAJOR GLOBAL HEALTH CHALLENGE IN ENDEMIC COUNTRIES

There is worldwide recognition that Malaria control requires integrated strategies

According to WHO latest figures:

3.2 billion people at risk of malaria

214 milion infections in 2015

428,000 deaths from malaria in 2015

About 78% of deaths are children <5 years

About 91% of deaths in Africa

*http://www.who.int/features/fact�les/malaria/en/

“MERCK HAS THE UNIQUE COMPETENCIES TO DELIVER INTEGRATED MALARIA SOLUTIONS WITHIN THE NEXT FEW YEARS”

DIAGNOSTICS DRUGS & DEVICES

VECTOR CONTROL DIGITAL SERVICES

• Focus on highly sensitive & specific malaria detection methods

• Develop associated methods for non-malaria fevers

Healthcare & Life Science

• Focus on high unmet medical needs

• Innovate to facilitate product delivery

Healthcare

• Support development of products & technologies to improve preventive measures against anopheles bites

Healthcare & Performance Materials

• Support development of higher education level for researchers & HCPs

• Development of eHealth solutions

Healthcare & Life Science & Performance Materials

“THE COMPANY HAS THE UNIQUE COMPETENCIES TO DELIVER INTEGRATED MALARIA SOLUTIONS WITHIN THE NEXT FEW YEARS”

DIAGNOSTICS DRUGS & DEVICES

VECTOR CONTROL DIGITAL SERVICES

• Focus on highly sensitive & specific malaria detection methods

• Develop associated methods for non-malaria fevers

Healthcare & Life Science

• Focus on high unmet medical needs

• Innovate to facilitate product delivery

Healthcare

• Support development of products & technologies to improve preventive measures against anopheles bites

Healthcare & Performance Materials

• Support development of higher education level for researchers & HCPs

• Development of eHealth solutions

Healthcare & Life Science & Performance Materials

Muse® Platform2 malaria assays

• Small & portable, highly simplified platform based on microscopy cytometry

• Already 1 IVD assay for measuring CD4 levels and %CD4 – HIV field. Launched in Africa

• Development of assays focused on P. falciparum & P. vivax and parasitemia levels

Drug Discovery &

Development portfolio

Potential new antimalarial drug from MMV (Medicines for Malaria Venture)

Screening Company’s compound library

New antimalarial Hits

Lead decision – potential new antimalarial drug

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First in Human (Phase I) study – potential new antimalarial drug

Drug Discovery platform (collaboration with University of Cape Town)

Muse® Platform2 malaria & 1 G6PD assays

• Small & portable, highly simplified platform based on microscopy cytometry

• Already 1 IVD assay for measuring CD4 levels and %CD4 – HIV field. Launched in Africa

• Development of assays focused on P. falciparum & P. vivax and parasitemia levels

Drug Discovery &

Development portfolio

Drug Discovery platform Merck/UCT (Univ. of Cape Town)

PeEF2 inhibitor from MMV (Medicines for Malaria Venture)

Screening Merck library

New antimalarial Hits

DP0 PeEF2 inhibitor

FIH/ challenge study PeEF2 inhibitor

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IR3535® as an Insect repellent against malaria transmission

• IR3535® is a very safe & effective mosquito repellent for women and children - WHO recommendation

Digital systems to support One Merck for Malaria

• Mobile platform: monitoring and supporting disease management for malaria applicable to all severe types of injectable treatments

• Educational mobile platform on malaria: Integrated approach to fight against malaria: Drugs/Diagnostics/Prevention for HCPs

IR3535® as an Insect repellent against malaria transmission

• IR3535® is a safe & effective mosquito repellent for women and children

Digital systems

• Mobile platform: monitoring and supporting disease management for malaria applicable to all severe types of injectable treatments

• Educational mobile platform on malaria: Integrated approach to fight against malaria: Drugs/Diagnostics/Prevention for HCPs

MALARIA DAY DEMONSTRATES COMMITMENT TO PATIENTS WITH MALARIA

Malaria Day 2015: Awareness CampaignIn honor of the World Malaria Day on April 25, 2015, Global Health R&D (Biopharma in collaboration with Life Science) hosted a worldwide ‘Malaria’ internal event to raise awareness about the tropical disease and current efforts and commitment of Merck KGaA, Darmstadt, Germany, to develop integrated antimalarial solutions. More than 2,000 pictures of employees demonstrating their support for malaria patients were collected from six continents.

A major gap in the spectrum of the prevention and treatment of malaria exists and we are focused on helping to fill this gap by developing antimalarials for the most vulnerable popuations in need.

- BELÈN GARIJO | Member of the Executive Board & CEO Healthcare, Merck KGaA, Darmstadt, Germany

Malaria Day 2016: Engagement CampaignFor the World Malaria Day on April 25, 2016, Global Health engaged the employees to demonstrate their support by raising internal funds dedicated to buy pediatric goods for a public hospital in Africa. More than 2,600 employees took part in this event to show their support for children with malaria, leading to the donation of 20 hospital beds and 80 bulk of mosquito nets to the ‘Bishop Edward Michaud Memorial Health Centre' in Kinondoni District of Dar Es Salaam in Tanzania. At the end of the event, a Company’s ambassador was randomly selected amongst the participants to represent Merck KGaA, Darmstadt, Germany, on the day of the donation.

Ambassador, Anna Carolina Melo (Import/Export Analyst, Supply Network Operations, in Brazil) representing the Company at the

Malaria Donation Event in November 2016 alongside with Stefan Maron (Managing Director South East Africa), Godfrey Matata (General

Manager East Africa) and Beatrice Greco (Head of Malaria and Diagnostics Innovation Cluster – Global Health R&D).

"Actions toward improving the health of the poorest populations in the world are an example to be followed. This is a huge benefit for the children and families of Tanzania, who suffer daily with the ills of disease and lack of resources. Our work is directly linked to health, but experiences like this demonstrate how the patient is the reason for everything we do!"

Anna Carolina Melo

MALARIA DAY 2017 THE POWER OF WE

WORLD MALARIA DAY April 25 – 28, 2017 | “Raise your hand for IR3535®”

WINNERGemma Casals Fàbregas, Environment Responsible – EHS, Spain

BELÉN GARIJOMember of the Executive Board & CEO Healthcare, Merck KGaA, Darmstadt Germany

Global Health Institute

The Company marked World and Malaria Day during the week of April 25th, 2017. The ‘Raise your hand’ campaign, organized by the Global Health Institute in collaboration with Performance Materials, promoted awareness around IR3535®.Produced and distributed by Merck KGaA, Darmstadt, Germany, IR3535® is used in insect repellents for complementary prevention from vector borne diseases, as malaria, dengue fever, ZIKA, Chikungunya and Lyme disease.

Over 40 sites in more than 30 different countries took part in the event by sending pictures of their hands, and highlighting an increased engagement and a collaborative spirit towards global health agenda. At the end of the event, according to the winning picture, a employee was selected to represent the Company during the distribution of insect repellents with IR3535® in a rural clinic in Ivory Coast.

“I am extremely proud to be part of this great initiative to fight Malaria. It shows a strong commitment with the most vulnerable people in Africa, mainly children. It’s nice to realize children’s hands could serve to help other children.Thanks again for giving me this opportunity at Malaria Day 2017. Feeling honored to be a new Company’s ambassador in Africa. To all communities, please join me and keep RAISING YOUR HAND AGAINST MALARIA”

Winning Picture by Gemma Casals Fàbrigas (Environment Responsible – Environment Health Safety, Spain)

Merck KGaADarmstadt, Germany

Global Health Institute,Ares Trading SA,

a subsidiary of Merck KGaA, Darmstadt, GermanyReg. No.: CHE-103.935.488.

Route de la Verrerie 61267 Coinsins, SwitzerlandTel: +41 – 21 – 354 50 00

GlobalHealth@emdgroup.comZA.MAL.16.11.001