The IndianaPhysician-Scientist

Initiative

David S. Wilkes, MDExecutive Associate Dean for Research Affairs

April 19, 2010

Changing Research LandscapeChanging Research Landscape

• Academia:Academia: Continued strengths in basic scienceContinued strengths in basic science Growing emphasis on translational Growing emphasis on translational

researchresearch

• Industry:Industry: Less basic science researchLess basic science research Seeks more clinical validation of Seeks more clinical validation of

academic researchacademic research

• Physician-scientist training meets Physician-scientist training meets these needs – but a growing these needs – but a growing shortageshortage

April 19, 2010Indiana CTSI Annual Meeting

The Indiana Physician-Scientist The Indiana Physician-Scientist InitiativeInitiative

• Established December 2009Established December 2009• Lilly Endowment grant – $60 millionLilly Endowment grant – $60 million• Strengthen translational researchStrengthen translational research• Recruit physician-scientistsRecruit physician-scientists• Support MD/PhD training programSupport MD/PhD training program• Create Indiana BiobankCreate Indiana Biobank• Support Global Health InitiativeSupport Global Health Initiative• Enhance Translational Acceleration Enhance Translational Acceleration

program (ITRAC)program (ITRAC)

Indiana CTSI Annual Meeting April 19, 2010

Physician-Scientist RecruitmentPhysician-Scientist Recruitment

• $37.5 million for recruitment$37.5 million for recruitment Matched by departmentsMatched by departments

• Highly-competitive Highly-competitive 5-year5-year startup startup packagespackages

• Seeking funded mid-level MD or Seeking funded mid-level MD or MD/PhD scientistsMD/PhD scientists

• Targeting, but not exclusively:Targeting, but not exclusively: CancerCancer NeurosciencesNeurosciences Diabetes / CardiovascularDiabetes / Cardiovascular

Indiana CTSI Annual Meeting April 19, 2010

Training Future Physician-ScientistsTraining Future Physician-Scientists

• $10 million endowment ensures future of $10 million endowment ensures future of IU Medical Scientist Training ProgramIU Medical Scientist Training Program

• Expanded in 2001 with Indiana Genomics Expanded in 2001 with Indiana Genomics Initiative (INGEN) supportInitiative (INGEN) support

• Full scholarship support for 50 studentsFull scholarship support for 50 students

• Partnership with Purdue Biomedical Partnership with Purdue Biomedical EngineeringEngineering

• Achieved NIH-designated MSTP statusAchieved NIH-designated MSTP status

Indiana CTSI Annual Meeting April 19, 2010

Indiana BiobankIndiana Biobank

• $6M investment in world class $6M investment in world class biobankbiobank

• >5,000 sq ft>5,000 sq ft

• Goal: Collect samples on Goal: Collect samples on allall eligible patients who enter our eligible patients who enter our health systemhealth system

• $2M investment for database $2M investment for database management & analysismanagement & analysis

Indiana CTSI Annual Meeting April 19, 2010

Global Health InitiativeGlobal Health Initiative

• $2M investment in international $2M investment in international researchresearch

• IU Center for Global HealthIU Center for Global Health

• Build on world-class Kenya programBuild on world-class Kenya program

• Build on ICTSI members’ expertise Build on ICTSI members’ expertise in infectious diseasein infectious disease

• Initiatives in China, Mexico, Initiatives in China, Mexico, Honduras and moreHonduras and more

Indiana CTSI Annual Meeting April 19, 2010

IITRACTRAC

• $2M investment in $2M investment in IIU Simon Cancer U Simon Cancer Center Center TTranslational ranslational RResearch esearch AAcceleration cceleration CCollaborativeollaborative

• Program management tools to “map” Program management tools to “map” research course from lab to clinicresearch course from lab to clinic

• Promotes collaboration, reduces cost, Promotes collaboration, reduces cost, speeds progressspeeds progress

• Expand beyond IUSCC to all scientistsExpand beyond IUSCC to all scientists

Indiana CTSI Annual Meeting April 19, 2010

IUSM rank in NIH fundingIUSM rank in NIH funding(among 128 schools of medicine)(among 128 schools of medicine)

36 34 3338 42 38 41 40 40 41 39 38 38

0

20

40

60

80

100

120

1996 1998 2000 2002 2004 2006 2008

1

*

* IUSM estimate – NIH no longer calculates rankings

*

(IUSM 17(IUSM 17thth among among public public schools of schools of medicine*)medicine*)

*

Indiana CTSI Annual Meeting April 19, 2010

Schools of Medicine Ranked by NIH Schools of Medicine Ranked by NIH AwardsAwards

(Publicly Supported)(Publicly Supported)

Rank Organization NameDollars

Awarded Awards PIsMarket

Share

Dollars Awarded per

PIAwards per

PINIH ARRA Funding Awarded FFY09*

% of FFY09 ARRA Funding

1 UNIVERSITY OF CALIFORNIA SAN FRANCISCO 417,729,542 953 636 3.68% 656,807 1.50 62,548,769 1.46%

2 UNIVERSITY OF MICHIGAN AT ANN ARBOR 319,054,417 774 505 2.81% 631,791 1.53 98,996,378 2.31%

3 UNIVERSITY OF CALIFORNIA LOS ANGELES 308,538,401 712 465 2.72% 663,523 1.53 60,597,591 1.41%

4 UNIVERSITY OF CALIFORNIA SAN DIEGO 287,149,545 597 357 2.53% 804,340 1.67 43,568,150 1.02%

5 UNIVERSITY OF WASHINGTON 282,275,945 698 480 2.49% 588,075 1.45 99,401,369 2.32%

6UNIVERSITY OF NORTH CAROLINA CHAPEL HILL 218,095,997 507 317 1.92% 688,000 1.60 65,198,541 1.52%

7 UNIVERSITY OF TEXAS SW MED CTR/DALLAS 166,602,608 476 315 1.47% 528,897 1.51 25,974,948 0.61%

8 UNIVERSITY OF ALABAMA AT BIRMINGHAM 156,389,071 386 257 1.38% 608,518 1.50 48,336,451 1.13%

9 UNIVERSITY OF COLORADO DENVER 154,713,699 411 287 1.36% 539,072 1.43 32,403,174 0.76%

10 UNIVERSITY OF MINNESOTA TWIN CITIES 145,726,343 387 272 1.28% 535,759 1.42 41,186,648 0.96%

11 UNIVERSITY OF VIRGINIA CHARLOTTESVILLE 139,408,744 357 239 1.23% 583,300 1.49 31,088,146 0.73%

12 UNIVERSITY OF MARYLAND BALTIMORE 135,600,249 347 231 1.20% 587,014 1.50 28,935,996 0.68%

13 UNIVERSITY OF IOWA 133,424,385 319 222 1.18% 601,011 1.44 32,310,129 0.75%

14 UNIVERSITY OF WISCONSIN MADISON 130,658,238 340 232 1.15% 563,182 1.47 38,771,301 0.90%

15UNIV OF MASSACHUSETTS MED SCH WORCESTER 126,878,826 333 211 1.12% 601,321 1.58 21,754,749 0.51%

16NEW YORK UNIVERSITY SCHOOL OF MEDICINE 126,417,736 322 221 1.11% 572,026 1.46 36,016,718 0.84%

17INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS 105,894,341 298 217 0.93% 487,992 1.37 27,587,648 0.64%

•ARRA awards are in addition to amounts listed at left

Indiana CTSI Annual Meeting April 19, 2010

Top-ranked Schools: More Funded Top-ranked Schools: More Funded PIsPIs

(Publicly Supported Schools of Medicine)(Publicly Supported Schools of Medicine)

Indiana CTSI Annual Meeting April 19, 2010