The immunoglobulin-like genetic predetermination The immunoglobulin-like genetic predetermination of the brain:of the brain:

the protocadherins, blueprint of the neuronal networkthe protocadherins, blueprint of the neuronal network

Naturwissenschaften (2001) N. Hilschmann, H.U. Barnikol et al.

Review Article

2002. 1. 14. 25th MPL Lab. Seminar A-Ram Jeong

The Structure and function of protocadherins. Protocadherins are cell-adhesion molecules. Their morphogenetic capacity is accomplished by their bipartite structure, which is very similar to that of classical cadherins. Besides a transmembraneous section they have an N-terminal extracellular part consisting of six domains and a C-terminal intracellular domain.

The protocadherin genes. We distinguish three classes of protocadherins: alpha, beta and gamma. In the genome there are three serially repeated V-gene sets, each followed by corresponding C-genes.

Immunoglobulin gene translocation and Immunoglobulin gene translocation and expressionexpression

Protocadherin gene translocation and expressionProtocadherin gene translocation and expression

The module system of the neuronal The module system of the neuronal networknetwork

References

1. Recent progress in protocadherin research

Experimental Cell Research 261, 13-18 (2000)

2. Phylogenetic analysis of the cadherin superfamily allows identification

J. Mol. Biol. (2000) 299, 551-572

3. Protocadherins and diversity of the cadherin superfamily

Journal of Cell Science 109, 2609-2611 (1996)

4. Cadherin superfamily genes: functions, genomic organization, and neurologic Diversity

GENES & DEVELOPMENT 14:1169–1180 (2000)