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Continuous health status monitoring of elderlypeople using flexible skin patch sensors

Japan

Prof. Takao Someya (PL)(The University of Tokyo)

Dr. Hiroshi Kajitani(NEC Corporation)

Sweden

Prof. Magnus Berggren (PL)(Linkoping University)

Dr. Tryggve Ljung (AbbVie AB)Dr. Björn Garplind (Invisense AB)

Dr. Göran Gustafsson (RISE Acreo)Dr. Michael Peolsson (RISE SICS)

Swedish-Japanese Joint Symposium

The Future of Skin Electronics

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Movie

The arrival of super aged society in Japan

3Innovation for healthy longevity society and social system reform are urgently required.

Aging in Japan

Super-aged in 2007Aging rate

27.3% in 2017 >30% in 2025

Super-aged, Worldwide(Moody’s)

13 countries by 202034 countries by 2030

Data: Cabinet Office, Government Of Japan, Ministry of Internal Affairs and Communications, National Institute of Population and Social Security Research, and Ministry of Health, Labor and Welfare, Japan.

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20

40

60

80

100

120

140

1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 2050 2060

5

0

10

15

20

25

30

35

40

45

0 -14 years old

15 - 64 years old

(%)

65 years old and older

Aging rate(>65 years old)

Projection

Popu

latio

n in

100

,000

Accessibility to information

4A safe and comfortable society will be realized when anyone can monitor

biometric information easily, accurately, anytime, and anywhere.

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Skin electronics

Epidermal electronicsScience 333, 838 (2011).

Human interface

Proc. of the 2016 ACM ISWC, 16 (2016).

Sci. Adv. 2, e1501856 (2016).

Adv. Mater. 29, 1 (2017).

Science 325, 21 (2009).

Adv. Mater. 29, 1703817 (2017).

Imperceptible electronics

Nature 499, 458 (2013).

Physical sensor

Pressure

Nat. Com., 4, 1859 (2013).

Adv. Funct. Mater. 27, 1604465 (2017).

UV

Chemical sensor

Sci. Transl. Med. 8,366ra165 (2016)

Microfluidic

Temperature

Nat. Mater., 12, 938 (2013). Nat. Mater., 11, 795 (2012).

Sweat

Nature, 529, 509 (2016).

Skin battery

Bio-fuel cell

Energy Environ. Sci. 10, 1581 (2017).

Healing

Adv. Healthc. Mater. 3, 1597 (2014).

Memory

ACS Nano 9, 558 (2015).

SensorDisplay Energy

System

Adv. Healt Mater. 4, 506 (2015).PNAS 112, 3920 (2015).

EEG

Nat. Mater., 14, 728-736 (2015).

IEEE Trans. Biomed. Eng., 60, 2848 (2013).

Adv. Mater., 25, 2773 (2013).

EMG ECG

Hydration

Skin modulus

Inorganic LED

OLED

QLED

Micro LED

Sci. Adv. 2, e1501856 (2016).

Sci. Rep., 4, 6074 (2014).

Blood oxygenation

StrainSci. Adv. 2, e1501856 (2016).

A skin display

6We have developed a skin display with stretchability of 45%.

is an array of micro-LEDs embedded in a thin rubber sheet.

Fabrication process and mechanical durability

2.5

2.0

1.5

1.0R

/R0

2000 4000 6000 8000 10000The number of cycles

0

10

8

6

4

2

00 50 100 150 200

New methodConventionalStrain 30%

Cyclic stretching tests

Pre-stretched rubber

Ultrathin substrate

Buckling

Lamination

Micro LEDStretchable Ag wires

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Relaxation of pre-stretch

A skin display attached to the hand

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A skin display can be nicely fitted on the skin due to its stretchability.It exhibits simple graphics with motion including a electrocardiogram

waveform measured with skin sensors.

Nanomesh electrodes on a hand

9It firmly adheres to the shape of the skin. It is ultrathin and lightweight.

A natural skin respiration is realized. There is no sense of fit.

Nanomesh electrodes

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Nanomesh electrodes

Skin

Water

A nanomesh adheres to the skin.

Au

Au

Process flow1. A nanomesh is made of polyvinyl-alcohol (PVA) by an electrospinning method.2. Gold patterns are formed by vacuum evaporation through a shadow mask.3. Nanomesh electrodes are laminated onto the skin with dissolving PVA by spraying water.

Spraying

Nature Nanotechnology (2017). DOI: 10.1038/nnano.2017.125

PVA

11A high level of conformability

Skin sensors with nanomesh electrodesNanomesh electrodes on a fingertip

1 mm

5 μm1 mm

50 μm

Nanomesh electrodes

A sweat pore Sweat & sweat pores

Nanomesh electrodeson a silicone skin

Biocompatibility test

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Dermatitis evaluate different substrates according to the patch test criteria of the ICDRG*. * International Contact Dermatitis Research Group

Three samples were attached to the forearm for a week.

silicone (1 mm thick)

parylene (1 μm thick)

nanomesh conductors

10 mm

forearm

doubtful positive reaction negative reaction(= No inflammation)

silicone (1 mm thick)

parylene (1 μm thick)

nanomesh conductors

Skin sensor to measure electrocardiogram

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Nanomesh electrodes attached on the body

Real-time monitoringby a smartphonep

g

A wireless module for transmitting data to a smartphone

A belly bande-textile

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1000

0 2 4 6 8 10 12

ECG

Time (s)

0

1000

0.4 0.8 1.2 1.6

ECG

Time (s)

2 4T

1000

Elastic conductor

Electrocardiogram waveform

A health-monitoring system with skin electronics

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Doctor @ hospital

Smart phone

# A waveform stored in memory was exhibited on a skin display in this work.

Skin sensors Skin displays #

FamilyNursing stuff

Patient @ home Patient @ home

A skin sensor system combined with skin display can realize a natural flow from measurement of biometric signals to display of information.

Data collectionsComfortable

AccurateSafe

Real space

Cyberspace

Cloud

AI-assisted diagnosis

FeedbackNaturalIntuitive

Safe

Overview of this project

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Schedule of the projectPromote social implementation by technologies to reduce discomfort in wearable devicesand realize a healthy life for elderly peopleNEC would like to contribute to improving the practicality of physical sensors developed atthe Univ. of Tokyo by providing wireless and packaging technologies.

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SummaryThe new-type wearable sensors with excellentwearing feeling have been developed by using skinelectronics.

A wireless module for skin sensors has beenminiaturized and datacollection platform has been developed.

We will conduct a sensing test integrating withSwedish chemical sensors.

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AcknowledgementsThis research is supported by JST and VINNOVA.

Berggren

Kajitani, NECEndo, NEC

Nakahara, NEC YorozuNEC

Someya, UT

Yokota, UT