the evolution of ion mobility ms - waters.com · ©2015 waters corporation 6 2001 linear field ims...
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©2015 Waters Corporation 1
The Evolution of Ion Mobility MS
©2015 Waters Corporation 2
2001 Linear Field IMS
©2015 Waters Corporation 3
Gate
MobilityRegion
StorageRegion Quadrupole
Mass Filter
ElectrosprayTip
Pusher
Detector
Reflectron
LensesCollision
Cell
SecondTransferRegion
Electric Field
FirstTransfer Region
Stacked RingIon Guide
Ions
©2015 Waters Corporation 4
2001 Linear Field IMS
2003 First T-Wave IMS
2004 Prototype SYNAPT Q-IMS-Tof
©2015 Waters Corporation 5
©2015 Waters Corporation 6
2001 Linear Field IMS
2003 First T-Wave IMS
2004 Prototype SYNAPT Q-IMS-Tof
2006 Synapt HDMS TriWave, DriftScope
©2015 Waters Corporation 7
©2015 Waters Corporation 8
The Challenge of Ion Mobility
©2015 Waters Corporation 9
2006 Synapt HDMS TriWave, DriftScope
2007 MALDI Synapt
2001 Linear Field IMS
2003 First T-Wave IMS
2004 Prototype SYNAPT Q-IMS-Tof
2009 Synapt G2 HDMS 2nd Gen TriWave & QuanTOF
©2015 Waters Corporation 10
©2015 Waters Corporation 11
2006 Synapt HDMS TriWave, DriftScope
2007 MALDI Synapt
2009 Synapt G2 HDMS 2nd Gen TriWave & QuanTOF
2010 MALDI Synapt G2 HDMS HDI Software, ETD
2001 Linear Field IMS
2003 First T-Wave IMS
2004 Prototype SYNAPT Q-IMS-Tof
2011 Synapt G2S HDMS StepWave
©2015 Waters Corporation 12
©2015 Waters Corporation 13
2006 Synapt HDMS TriWave, DriftScope
2007 MALDI Synapt
2009 Synapt G2 HDMS 2nd Gen TriWave & QuanTOF
2010 MALDI Synapt G2 HDMS HDI Software, ETD
2011 Synapt G2S HDMS StepWave
2001 Linear Field IMS
2003 First T-Wave IMS
2004 Prototype SYNAPT Q-IMS-Tof
2013 Synapt G2Si HDMS Enhancing Workflows (implementing CCS) Dedicated IMS Apps Software (UNIFITM), MS Compare, IntellistartTM
©2015 Waters Corporation 14
CCS
Structure Separation
Sensitivity Specificity
©2015 Waters Corporation 15
Opportunity
Measure CCS of every ion in every
analysis Incorporate CCS into routine workflows
©2015 Waters Corporation 16
2006 Synapt HDMS TriWave, DriftScope
2007 MALDI Synapt
2009 Synapt G2 HDMS 2nd Gen TriWave & QuanTOF
2010 MALDI Synapt G2 HDMS HDI Software, ETD
2011 Synapt G2S HDMS StepWave
2001 Linear Field IMS
2003 First T-Wave IMS
2004 Prototype SYNAPT Q-IMS-Tof
2013 Synapt G2Si HDMS Enhancing Workflows (implementing CCS) Dedicated IMS Apps Software (UNIFITM), MS Compare, IntellistartTM
2015 Accessible Ion Mobility
©2015 Waters Corporation 17
Beyond Resolution
©2015 Waters Corporation 18
©2015 Waters Corporation 19
Dual Channel 7.2GHz (up-sampled) 10-bit ADC
QuanTof2 Detector
x 1
x 0.03
ADC High Gain Channel
ADC Low Gain Channel
Peak Processing
Peak processing
ADC Test signal
Apply calibration
Combine From MS
ADC Amplifier
©2015 Waters Corporation 20
Benefits of QuanTof2
©2015 Waters Corporation 21
UN
IFI
Streamlined Instrument Controls
Seamless Workflows
Integrated Ion Mobility Tools Sophisticated Reporting
UNIFI: Taking Data to Knowledge
UNIFI 1.8
©2015 Waters Corporation 22
Routine ion mobility
• Just press START
• Simply Acquire
• Get to the Answers
Seamlessly from sample to answers
©2015 Waters Corporation 23
Clarity cleaner mass spectra
Confidence valuable CCS information for
every ion
System Productivity with UNIFI analytical
workflows
Benefits of Routine Ion Mobility
©2015 Waters Corporation 24
518.2235 m/z
441.2758 m/z
289.1923 m/z
617.3076 m/z 236.6 Å2 Verapamil- CH2 + C6H8O6
Benefits of Routine Ion Mobility Ion Mobility Off
©2015 Waters Corporation 25
518.2235 m/z
441.2758 m/z
289.1923 m/z
617.3076 m/z 236.6 Å2 Verapamil - CH2 + C6H8O6
Clarity
Unlimited Product ion
HDMSE
Benefits of Routine Ion Mobility Ion Mobility On
©2015 Waters Corporation 26
Vion measured CCS(N2) values
Reserpine - 609.28 m/z : 252 Å2 - 0.10 % RSD
LueEnk – 556.27 m/z : 230 Å2 - 0.15 % RSD
Terfenadine – 472.32 m/z : 230 Å2 - 0.12 % RSD
Verapamil – 455.29 m/z : 211 Å2 - 0.17 % RSD
Sulphadimethoxine – 311.08 m/z : 168 Å2 - 0.15 % RSD
Caffine – 195.08 m/z : 136 Å2 - 0.22 % RSD
Data from 400 injections over 33 hours
<2% time after time
©2015 Waters Corporation 27
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Axis Title
Synapt WIV ISP/Vion IMS Q ToF Comparison April 2015
Pesticide
WIV ISP Study: SYNAPT/Vion Comparison for Pesticides
Dr Severine Goscinny, Scientific Institute of Public Health, Belgium Coming soon...
Confidence
©2015 Waters Corporation 28
Confidence
Benefits of Routine Ion Mobility
©2015 Waters Corporation 29
153 Coeluting Components Resolved with Vion Mobility
System Productivity
©2015 Waters Corporation 30
©2015 Waters Corporation 31
Vion IMS QTof presentations this week
©2015 Waters Corporation 32
Experience the best of ASMS with Waters
©2015 Waters Corporation 33
Presentation at ASMS highlighting Waters IMS enabled technology
Waters Presentations at ASMS
– All
o 17 Orals
o 102 Posters
– Including IMS enabled technology
o 8 Orals (47%)
o 27 Posters (26%)
©2015 Waters Corporation 34
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©2015 Waters Corporation 35
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Year Total AbstractsAbstracts containing
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% containing "IMS"
or "mobility"
2000 1619 30 1.9
2007 2872 127 4.4
2014 3541 348 9.8
Introduction of first commercial IMS system (SYNAPT HDMS)
©2015 Waters Corporation 36
Presentation at ASMS highlighting Waters IMS enabled technology
Session Type Location Time Title Presenters Affiliations
Quantitative Analysis in Drug
Discovery for Small MoleculesOral Ballroom 220/221 4:10pm - 4:30pm Comparison of travelling wave IMS-QTof geometries and acquisition modes for quantitative analysis
M ark Wrona* (1) ; Yun Alelyunas(1) ; Jayne Kirk(2) ; M artin Palmer(2)
; Nick Tomczyk(2) ; Russell M ortishire-Smith(2)
(1) Waters Corporation, M ilford, M A; (2) Waters M S Technologies,
Wilmslow, United Kingdom
Advances in Software and Hardware
to Improve DMPK WorkflowsOral Ballroom 220/221 9:10am - 9:30am Fully integrated novel IMS-QTof informatics platform for rapid drug screening and elucidation
Russell M ortishire-Smith* (1) ; Jayne Kirk(1) ; Nick Tomczyk(1) ;
M artin Palmer(1) ; Richard Denny(1) ; A lan Prile(1) ; Simon
Cubbon(1) ; Yun Alelyunas(2) ; M ark Wrona(2)
(1) Waters M S Technologies, Wilmslow, United Kingdom; (2) Waters
Corporation, M ilford, M A
Energy, Petroleum, & Biofuels:
Advances in MS Design & InformaticsOral Ballroom 222/224 8:30am - 8:50am
Comparison of atmospheric solid analysis probe with other atmospheric pressure ionization sources by
ion mobility-mass spectrometry using PetroOrg software
M athilde Farenc* (1, 5) ; Yuri E. Corilo(2, 3) ; Priscila M . Lalli(3) ;
Eleanor Riches(4) ; Ryan P. Rodgers(2) ; Carlos Afonso(1) ; P ierre
Giusti(5
(1) University o f Rouen, M ont Saint A ignan, France; (2) National
High M agnetic Field Laboratory, Tallahassee, FL; (3) Future Fuels
Institute, Tallahassee, FL; (4) Waters Corporation, Wilmslow, UK; (5)
TOTAL Refining and Chemicals, Gonfreville l'Orcher, France
Energy, Petroleum, & Biofuels:
Advances in MS Design & InformaticsOral Ballroom 222/224 9:50am - 10:10am Algae Biomass Characterization by Traveling Wave Ion Mobility Mass Spectrometry
M aira Fasciotti* (1) ; Ingrid Chastinet Ribeiro(1) ; Paulo Roque
M artins Silva(1) ; Thays V. M onteiro(1) ; Gustavo H. M . F. Souza(2) ;
Julia Itaco lomy da Silva(1) ; Romeu J. Daroda(1) ; Valnei S. Cunha(1)
; Claudia M aria Luz Lapa Teixeira(3) ; Amarjit S. Sarpal(1)
(1) Inmetro, Duque De Caxias, Brazil; (2) Waters Coorporation, Rio
de Janeiro, Brazil; (3) National Institute of Technology, INT, Rio de
Janeiro, Brazil
Poster Poster Poster 239 - Natural ProductsUtilization of a Novel Geometry Travelling Wave IMS/Q-TOF Mass Spectrometer for Natural Products
Profiling
Anthony T. Iavarone(1) ; Ulla N. Andersen(1) ; Darren Hewitt(2) ;
Andrew Baker* (3)
(1) UC Berkeley, Berkeley, CA; (2) Waters, Wilmslow, UK; (3) Waters,
Inc., P leasanton, CA
Poster PosterPoster 133 - Ion Mobility:
Theory
Comparison of CCS(N2) measurements obtained from two different T-wave IMS systems with direct
measurements using a drift tube IMSKevin Giles; M artin Palmer; Keith Richardson; Nick Tomczyk* Waters M S Technologies, Wilmslow, United Kingdom
Poster Poster
Poster 651 - Energy:
Hydrocarbon and
Petrochemical
Supercritical Fluid Chromatography Coupled with Ion Mobility-Mass Spectrometry for Comprehensive
Profiling of Petroleum SamplesEleanor Riches* (1) ; Yunju Cho(2) ; Sunghwan Kim(2)
(1) Waters Corporation, Wilmslow, United Kingdom; (2) Chemistry
Department, Kyungpook National Universit, Daegu, South Korea
Poster PosterPoster 146 - Ion Mobility:
InstrumentalCharacterizing a T-Wave Enabled Multi-pass Cyclic Ion Mobility Separator
Kevin Giles* ; Jason L Wildgoose; Steven Pringle; David Langridge;
Peter Nixon; John Garside; Peter CarneyWaters Corporation, Wilmslow, United Kingdom
Poster Poster
Poster 205 - Top down Protein
Analysis: Relatively Pure
Sample
Improving Protein Sequence Coverage and Identification of Oxidation Sites via Top/Middle -Down
Fragmentation and Ion-mobility Time-of-flight Mass Spectrometry
Stephane Houel(1) ; Catalin Doneanu(1) ; Asish Chakraborty* (1) ;
Andrew Tudor(2) ; Nick Tomczyk(2) ; M artin Palmer(2) ; Weibin
Chen(1)
(1) Waters Corp, M ilford, M A; (2) Waters M S Technologies,
Wilmslow, United Kingdom
Poster PosterPoster 144 - Ion Mobility:
Instrumental
Ultra-definition multiplex acquisition (UDMSE) of whey protein supplements by traveling wave ion
mobility mass spectrometry (TWIM-MS)
Gustavo H. M . F. Souza* (1) ; M aÃ-ra Fasciotti(2) ; Bruno C.
Garrido(2) ; Daniela C. Lourenço(2) ; Andrea F. M acedo(3) ;
M ariana S. L. Ferreira(3) ; Luiz Claudio Cameron(3)
(1) Waters Corporation, Rio de Janeiro, Brazil; (2) INM ETRO, Duque
De Caxias, Brazil; (3) UNIRIO, Rio de Janeiro, Brazil
Poster PosterPoster 131 - Ion Mobility:
TheoryPredicting Theoretical Collision-cross Sections for Small Molecules
Bela Paizs* (1) ; Keith Richardson(2) ; Jeff Brown(2) ; M ike
M orris(2) ; Zo ltan Takats(3)
(1) Bangor University, Bangor, UK; (2) Waters Corporation,
Wilmslow, United Kingdom; (3) Imperial College London, London,
N/A
Instrumentation: Time-of-flight and QTOF Oral Hall 5 8:50am - 9:10am Novel operating modes of an ion mobility quadrupole time-of-flight hybrid instrument Jason L Wildgoose* ; Kevin Giles; Keith Richardson; Steven Pringle Waters Corporation, M anchester, United Kingdom
Poster Poster
Poster 123 - High Mass
Accuracy/High Performance MS:
Instrumentation
A novel method of m/z drift correction for oa-TOF mass spectrometers based on construction of libraries of 'matrix'
componentsM artin Green* ; Keith Richardson; M artin Palmer; Nick Tomczyk Waters Corporation, M anchester, UNITED KINGDOM
Poster PosterPoster 233 - Drug Metabolism:
Qualitative Analysis
Comprehensive metabolite detection by utilising both positive and negative ionization on an integrated microfluidic-
ion source with CCS measurements
Richard Gallagher* (1) ; Christine Pattison(1) ; Kathryn Pickup(1) ;
John Chipperfield(2) ; M ike M cCullagh(2) ; Jim M urphy(3) ; David
Douce(2)
(1) AstraZeneca, M acclesfield, UK; (2) Waters (M S Technologies),
Wilmslow, United Kingdom; (3) Waters, M ilford, USA
Ion Mobility: Structures Oral Room 123/124 8:50am - 9:10am Pushing the boundaries of small molecule analysis: using ion mobility MS and gas-phase infrared spectroscopy to study
protonation site isomers
Jasper Boschmans* (1) ; Stephan Warnke(2) ; Jongcheol Seo(2) ;
Jonathan P. Williams(3) ; Kevin Pagel(2, 4) ; Gert von Helden(2) ;
Filip Lemière(1) ; Frank Sobott(1)
(1) University o f Antwerp, Antwerp, Belgium; (2) Fritz-Haber-Institut
der M ax-Planck-Gesellschaft, Berlin, Germany; (3) Waters
Corporation, M anchester, UK; (4) Freie Universität Berlin, Berlin,
Germany
Poster Poster Poster 568 - Ion Mobility: StructuresInvestigation of Ion Mobility Mass Spectrometry Analysis of Electrochemically Generated Oxidation Products of Opiates
and Comparison with Theoretical CCS Values
Cris Lapthorn(1) ; Frank Pullen(1) ; Susana da Silva Torres(2) ; M ark
R. Taylor(2) ; Russell M ortishire-Smith(3) ; Jayne Kirk* (3) ; Andrew
Baker(4)
(1) University o f Greenwich, Chatham M aritime, UK; (2) Pfizer,
Sandwich, UK; (3) Waters Corp, M anchester, UK; (4) Waters, Inc.,
P leasanton, CA
Poster Poster Poster 631 - Systems Biology: Other Studies of Heart Regeneration in Zebrafish: A Multi-Omics/System Biology ApproachLeanne C. Nye* (1) ; Lee Gethings(2) ; Cheng Shuk Han(3) ; Yun Wah
Lam(3) ; Fatemeh Babaei(3) ; Chi Chi Liu(3) ; A lfred W. H. Chan(3) ;
Robert P lumb(4) ; Ian D. Wilson(1)
(1) Imperial College, London, UK; (2) Waters Corporation, Wilmslow,
UK; (3) City University, Hong Kong, Hong Kong; (4) Waters, M ilford,
M A
Poster PosterPoster 267 - Lipids: ID and Structural
Analysis
Characterization and Collision Cross Section Determination of Obesity Related Lipids Within Mouse Models Using
Travelling Wave IMS-QTof Mass Spectrometry
Gertjan Kramer(1) ; Nicholas Dekker(1) ; Lee A Gethings* (2) ; John
P. Shockcor(2) ; James I. Langridge(2) ; Johannes P.C. Vissers(2) ;
Johannes M .F.G. Aerts(1)
(1) Academic M edical Centre, University o f Amsterdam,
Amsterdam, Netherlands; (2) Waters Corporation, M anchester,
United Kingdom
Poster PosterPoster 251 - Lipids: Quantitative
AnalysisSkyline Validation of Quantitative Measurements from High-Resolution LC-IMS-MS Lipidomics Profiling Experiments
J. Will Thompson* (1) ; Laura Dubois(1) ; Brian Pratt(2) ; M ichael J.
M accoss(3) ; Giuseppe Astarita(4) ; Brendan M aclean(2) ; Arthur
M oseley(5)
(1) Duke University School o f M edicine, Durham, NC; (2) University
o f Washington, Seattle, WA; (3) Univ of Washington, Seattle, WA; (4)
Waters Corporation, M ilford, M A; (5) Duke University School o f
M edicine, Durham, NC
Ion Mobility: Small Molecules,
Pharmaceuticals, and DMPKOral Ballroom 220/221 9:30am - 9:50am
Comprehensive Screening and Characterisation of Metabolites and Biomolecules by Collisional Cross Section using a
Novel Geometry Travelling-Wave IMS-QTof Mass Spectrometer
Richard Gallagher(1) ; Christine Pattison(1) ; Kathryn Pickup(1) ; Nick
Tomczyk(2) ; M artin Palmer(2) ; Jason Wildgoose(2) ; Darren
Hewitt(2) ; Daniel Weston* (2)
(1) Astrazeneca, M acclesfield, United Kingdom; (2) Waters,
Wilmslow, United Kingdom
Synthetic Polymers Oral Theater 2:30pm - 2:50pmCharacterization of atmospheric pressure polyolefin pyrolysis products by Fourier transform mass spectrometry and
ion mobility - mass spectrometryCarlos Afonso* (1) ; M athilde Farenc(1, 2) ; M atthias Witt(3) ; Kirsten
Craven(4) ; Caro line Barrère-M angote(2) ; P ierre Giusti(2)
(1) University o f Rouen, M ont Saint A ignan, France; (2) TOTAL
Refining and Chemicals, Gonfreville l'Orcher, France; (3) Bruker
Daltonik GmbH, Bremen, Germany; (4) Waters, M anchester, UK
Poster PosterPoster 123 - Environmental Analysis:
GeneralTravelling Wave Ion Mobility Enhanced Separation of Poly-Halogenated Dioxins and Furans in Controlled Burn Samples Kari Organtini* (1) ; Lauren M ullin(2, 3) ; Adam Ladak(3)
(1) The Pennsylvania State University, State College, PA; (2) M TM
Research Centre Ã-rebro University, Ã-rebro , Sweden; (3) Waters
Corporation, M ilford, M A
Poster Poster Poster 62 - PolymersIon Mobility-Mass Spectrometry: A Novel Approach to Screening for Extractable and Leachable Components from
Packaging MaterialBaiba Cabovska* (1) ; Eleanor Riches(2) ; Cristina Nerin(3) ;
M argarita Aznar(3) ; P ilar A lfaro(3)
(1) Waters Corporation, M ilford, M A; (2) Waters Corporation,
Wilmslow, United Kingdom; (3) CPS-University o f Zaragoza,
Zaragoza, Spain
Poster PosterPoster 646 - Ion Mobility: Small
Molecule and MetabolomicsDemonstration of Collisional Cross Section Value Conservation Across LC and GC Analyses
Lauren M ullin* (1, 2) ; Gareth Cleland(2) ; M ike M cCullagh(3) ; Ingrid
Ericson Jogsten(1)
(1) M TM Research Centre Ã-rebro University, Ã-rebro, Sweden; (2)
Waters Corporation, M ilford, M A; (3) Waters Corporation,
Wilmslow, UK
Poster PosterPoster 451 - Informatics: Protein ID
and QuantificationLarge Scale Quantitation of Stable Isotope Labelled Proteomes Using Retention and Drift Time Profiling
Andrew Collins(1) ; Antony M cCabe(1) ; Ian M orns(3) ; Johannes
PC Vissers* (2) ; Andrew R Jones(1)
(1) Institute of Integrative Bio logy, University o f Liverpool, UK; (2)
Waters Corporation, M anchester, UK; (3) Nonlinear Dynamics
Limited, Newcastle upon Tyne, UK
Poster PosterPoster 636 - Ion Mobility: Complex
Mixtures
A Novel Strategy to Screen and Profile Steviol Glycosides of Natural Sweeteners in Food Using Microfluidic UPLC Ion
MobilityRamesh P Rao* (1) ; M ichael M cCullagh(1) ; David Douce(1) ;
Séverine Goscinny(2)
(1) Waters Corporation, M anchester, United Kingdom; (2) Scientific
Institute of Public Health, Brussels, Belgium
Poster Poster
Poster 588 - Proteomics:
Quantitative - Chemical Labeling
Methods
TMT 10-plex Quantitation by Travelling Wave IMS-QTof Mass SpectrometryDominic Helm(2) ; Chris Hughes* (1) ; Jason L Wildgoose(1) ; Keith
Richardson(1) ; Nick Tomczyk(1) ; James I Langridge(1) ; Johannes
PC Vissers(1) ; Bernhard Kuster(2)
(1) Waters Corporation, M anchester, UK; (2) Technische
Universität M ünchen, Freising, GERM ANY
Poster PosterPoster 634 - Ion Mobility: Complex
Mixtures
Using the Routine Separation Dimension and Identification Criteria of Microfluidic UPLC Ion Mobility to Enhance
Specificity in Screening Complex SamplesM ichael M ccullagh(1) ; C.A.M Pereira(2) ; J.H Yariwake(2) ; David
Douce* (1)
(1) Waters (M S Technologies), Wilmslow, United Kingdom; (2)
Universidade de Sao Paulo, Sao Paulo, Brazil
Poster PosterPoster 649 - Ion Mobility: Small
Molecule and MetabolomicsThe analysis of Bile Acids: Enhancement of specificity using an Ion Mobility-TOFMS based approach
Jonathan P. Williams* (1) ; Jonas Abdel-Khalik(2) ; Yuqin Wang(2) ;
Sarah M . Stow(3) ; M ark Towers(1) ; Giuseppe Astarita(1) ; James
Langridge(1) ; William J. Griffiths(2)
(1) Waters, M anchester, United Kingdom; (2) College of M edicine,
Swansea, UK; (3) Vanderbilt University, Nashville, TN, USA,
Nashville, TN
Poster Poster Poster 208 - Toxicology A Novel Screening Approach for the Detection of Toxicologically Relevant Substances Nayan S. M istry; Jeff Goshawk; M ichelle Wood* Waters, Wilmslow, United Kingdom
Poster PosterPoster 631 - Ion Mobility: Complex
Mixtures
Microfluidic UPLC Ion Mobility: A New Approach to Authentication and Routine Screening of Ginsenoside Isomers in
Functional Food ProductsM ichael M ccullagh* ; John Chipperfield; Ramesh P Rao; David
DouceWaters, M anchester, United Kingdom
Poster PosterPoster 633 - Ion Mobility: Complex
Mixtures
Baby Elephants Can Surf: Using the Selectivity of Ion Mobility When Screening Multi-class Pesticides in Fruit and
VegetablesSeverine Goscinny* (1) ; M ichael M cCullagh(2)
(1) Scientific Institute of Public Health, Brussels, Belgium; (2)
Waters, M anchester, United Kingdom
Poster PosterPoster 642- Ion Mobility: Small
Molecule and MetabolomicsThe importance of charge isomers in quantitation; ion mobility mass spectrometry of fluoroquinolone antibiotics
Cris Lapthorn* (1) ; M ike M cCullagh(2) ; Sara Stead(2) ; M artin
Palmer(2) ; Kevin Giles(2) ; Keith Richardson(2) ; Jasper
Boschmans(3) ; Frank Sobott(3) ; Frank Pullen(1) ; Babur
Chowdhry(1) ; George Perkins(4)
(1) University o f Greenwich, Chatham M aritime, UK; (2) Waters Corp,
M anchester, UK; (3) University o f Antwerp, Antwerp, Belgium; (4) 149
Hickory Corner Road, M ilford, NJ
Poster PosterPoster 647 - Ion Mobility: Small
Molecule and MetabolomicsIon mobility data in metabolite identification: a Mass-MetaSite approach
Ismael Zamora(1) ; Kevin Bateman(3) ; Fabien Fontaine* (4) ;
Russell M ortishire(2) ; Ian M cIntosh(3)
(1) Lead M olecular Design, S.L., Sant Cugat Del Valles, SPAIN; (2)
Waters Corp, M ilford, M S; (3) M erck, West Point, PN; (4) M olecular
Discovery, London, UK
Poster PosterPoster 648 - Ion Mobility: Small
Molecule and Metabolomics
Multidimensional analytical approaches: combining ion mobility and spectrophotometric detection with current MS-
based metabolomics and lipidomics workflows
Giuseppe Paglia* (1) ; Tommaso Pacini(2) ; Steinn
Gudmundsson(2) ; A Eugenio Chiaravalle(1) ; Sigurdur
Brynjo lfsson(2) ; Bernard O Palsson(2) ; Giuseppe Astarita(3)
(1) IZS Puglia e Basilicata, Foggia, Italy; (2) Center For Systems
Bio logy, Reykjavik, Iceland; (3) Waters Corporation, M ilford, M A
©2015 Waters Corporation 37
Session: Advances in Software and Hardware to Improve DMPK Workflows When: Monday 09.10 to 09.30 in Ballroom 220/221
©2015 Waters Corporation 38
Session: Advances in Software and Hardware to Improve DMPK Workflows When: Monday 09.10 to 09.30 in Ballroom 220/221
©2015 Waters Corporation 39
Session: Advances in Software and Hardware to Improve DMPK Workflows When: Monday 09.10 to 09.30 in Ballroom 220/221
©2015 Waters Corporation 40
Session: Advances in Software and Hardware to Improve DMPK Workflows When: Monday 09.10 to 09.30 in Ballroom 220/221
©2015 Waters Corporation 41
Session: Advances in Software and Hardware to Improve DMPK Workflows When: Monday 09.10 to 09.30 in Ballroom 220/221
©2015 Waters Corporation 42
Session: Quantitative Analysis in Drug Discovery for Small Molecules When: Monday 16.10 to 16.30 in Ballroom 220/221
©2015 Waters Corporation 43
Session: Quantitative Analysis in Drug Discovery for Small Molecules When: Monday 16.10 to 16.30 in Ballroom 220/221
©2015 Waters Corporation 44
Session: Quantitative Analysis in Drug Discovery for Small Molecules When: Monday 16.10 to 16.30 in Ballroom 220/221
©2015 Waters Corporation 45
Session: Quantitative Analysis in Drug Discovery for Small Molecules When: Monday 16.10 to 16.30 in Ballroom 220/221
©2015 Waters Corporation 46
Session: Poster 239 – Natural Products When: Monday 10.30 to 13.00
©2015 Waters Corporation 47
Session: Poster 239 – Natural Products When: Monday 10.30 to 13.00
©2015 Waters Corporation 48
Session: Poster 239 – Natural Products When: Monday 10.30 to 13.00
©2015 Waters Corporation 49
Session: Poster 239 – Natural Products When: Monday 10.30 to 13.00
©2015 Waters Corporation 50
Session: Poster 239 – Natural Products When: Monday 10.30 to 13.00
©2015 Waters Corporation 51
Session: Poster 133 – Ion Mobility: Theory When: Monday 10.30 to 13.00
©2015 Waters Corporation 52
Session: Poster 133 – Ion Mobility: Theory When: Monday 10.30 to 13.00
©2015 Waters Corporation 53
Session: Poster 133 – Ion Mobility: Theory When: Monday 10.30 to 13.00
©2015 Waters Corporation 54
Session: Poster 133 – Ion Mobility: Theory When: Monday 10.30 to 13.00
©2015 Waters Corporation 55
Session: Poster 510 - Protein Therapeutics: Structural Characterization When: Tuesday 10.30 to 13.00
©2015 Waters Corporation 56
Session: Poster 510 - Protein Therapeutics: Structural Characterization When: Tuesday 10.30 to 13.00
©2015 Waters Corporation 57
Session: Poster 510 - Protein Therapeutics: Structural Characterization When: Tuesday 10.30 to 13.00
©2015 Waters Corporation 58
Session: Ion Mobility: Small Molecules, Pharmaceuticals and DMPK When: Monday 09.30 to 09.50 in Ballroom 220/221
©2015 Waters Corporation 59
Session: Ion Mobility: Small Molecules, Pharmaceuticals and DMPK When: Monday 09.30 to 09.50 in Ballroom 220/221
©2015 Waters Corporation 60
Session: Ion Mobility: Small Molecules, Pharmaceuticals and DMPK When: Monday 09.30 to 09.50 in Ballroom 220/221
©2015 Waters Corporation 61
Session: Ion Mobility: Small Molecules, Pharmaceuticals and DMPK When: Monday 09.30 to 09.50 in Ballroom 220/221
©2015 Waters Corporation 62
Session: Ion Mobility: Small Molecules, Pharmaceuticals and DMPK When: Monday 09.30 to 09.50 in Ballroom 220/221
©2015 Waters Corporation 63
Session: Poster 62: Polymers When: Tuesday 12.00 to 14.30
©2015 Waters Corporation 64
Session: Poster 62: Polymers When: Tuesday 12.00 to 14.30
©2015 Waters Corporation 65
Session: Poster 62: Polymers When: Tuesday 12.00 to 14.30
©2015 Waters Corporation 66
Session: Poster 62: Polymers When: Tuesday 12.00 to 14.30
©2015 Waters Corporation 67
Session: Poster 62: Polymers When: Tuesday 12.00 to 14.30
©2015 Waters Corporation 68
Session: Poster 208: Toxicology When: Tuesday 12.00 to 14.30
©2015 Waters Corporation 69
Session: Poster 208: Toxicology When: Tuesday 12.00 to 14.30
©2015 Waters Corporation 70
Session: Poster 208: Toxicology When: Tuesday 12.00 to 14.30
©2015 Waters Corporation 71
Session: Poster 208: Toxicology When: Tuesday 12.00 to 14.30
©2015 Waters Corporation 72
Guide to Waters at ASMS 2015