The Electrolitolysis ( ELLYS )

The Electrolitolysis ( ELLYS )

FROM THE BASIC RESEARCH TO THE FORMULATION OF A NEW

THERAPEUTIC METHOD

Ernesto FinaDipartimento Nefro-Urologico A.O.R.N. Cardarelli Napoli

76° Congresso Nazionale SIU - Corso CLU

ELECTROLYTIC DISSOLUTION OF URINARY STONES

O

ELECTROLITOLYSISO

ELLYS

ELECTROLYTIC DISSOLUTION OF URINARY STONES

O

ELECTROLITOLYSISO

ELLYS

Direct anodic oxidation

Oxidation by born oxigen

Protolysis

Takes place by creating an electrolytic circuit, who’s ionic medium is the urine,in contact with the positive pole(anode),through:

The ELLYS is effective on all types of stones

stones “hardness”

With a Dissolution rate

D. R. ( mg\h )

applied current intensity

“Hardness of stones

“Hardness” = resistance to electrochemical dissolution

It’s inversely proportional to dissolution rate (D.R.)

Hardness Dissolution rate

Hardness of main stone compounds

0102030405060708090

100

Oxalate Cystine Ac. Urico Phosphate

OxalateCystineAc. UricoPhosphate

Tas

so d

i dis

solu

zion

eM

g\h

Current intensity( mA )

Current intensity( mA )

The dissolution rate ( D.R. ) is directlyproportional to the current intensity (C.I.)

D.R. C.I. and more specifically to the current density

(C.D.),it is to the ratio between C.I.and electrode surface

D.R. C.D.

Stones submitted to ELLYSFoto 1

Stones submitted to ELLYSFoto 1

Foto 2Foto 2

Foto 3Foto 3

Foto 4Foto 4

Foto 5Foto 5

“In vitro”experimentation results“In vitro”experimentation results

The ELLYS is effective against :The ELLYS is effective against :

Urinary stones

Crystals and salts

Bacteria *

* Wong HY and Griffit D.P. : Iontophoresis in Medicine : Possible applications in Urology . Minim. Invasive Therapy ; 1993, 2.51

“Ex vivo experimental modelon pig bladders

“Ex vivo experimental modelon pig bladders

“Ex vivo”experimental model on pig bladders

“Ex vivo”experimental model on pig bladders

Results of “ex vivo trialResults of “ex vivo trial

C.I.employable without lesions = 30 mA

ELLYS effective at these C.I. values

Possible therapeuticapplications of ELLYS

Possible therapeuticapplications of ELLYS

Stone therapy

Therapy of kidney infected cavities

Prevention of urolithiasis

Equipment for ELLYSEquipment for ELLYS

Spiral stent Power Supplier

( S.EL.S.) ( battery and electronic circuit)+

Spiral stent ( S.EL.S )

Spiral stent ( S.EL.S )

Stone disease therapyStone disease therapy

Non impacted single or multiple stones into inferior calyx or pelvis

Residual fragments to E.S.W.L. Relapsing stone disease in multitreated patients

Prevention of stone diseasePrevention of stone disease

The ELLYS is very effective on growing crystals through:

Spiral miniaturized stent left in cavities (implant)and connected with a battery embedded in a sub- cutaneous pouch

Therapy of infectionsTherapy of infections

The continous current delivery in a saline solutionmakes it completely sterile through born

Oxygen and Chlorine( Wong e Coll. )

The continous current delivery in a saline solutionmakes it completely sterile through born

Oxygen and Chlorine( Wong e Coll. )

The ELLYS therefore can be employed :The ELLYS therefore can be employed :

To sterilize kidney infected cavities

To get the contemporary dissolution and sterilization of infected stones ( struvite )

The ELLYS want to realize , with the help of modern technologies, the old dream of the

Urologist ,that is the total stone disappearance

The ELLYS want to realize , with the help of modern technologies, the old dream of the

Urologist ,that is the total stone disappearance

The ELLYS want to realize , with the help of modern technologies, the old dream of the

Urologist ,that is the total stone disappearance

The ELLYS want to realize , with the help of modern technologies, the old dream of the

Urologist ,that is the total stone disappearance