the edu-k pedagogy of learning and the content framework of design
DESCRIPTION
Pedagogical Day at FARMA 2011. The EDU-K pedagogy of Learning and the Content Framework of Design. David Needham Professor, Dept Mechanical Engineering and Material Science Duke University, Durham NC 27708, USA [email protected]. SKYPE: needdavid. - PowerPoint PPT PresentationTRANSCRIPT
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The EDU-K pedagogy of Learning and the Content Framework of Design
David NeedhamProfessor,
Dept Mechanical Engineering and Material ScienceDuke University,
Durham NC 27708, USA
SKYPE: needdavid
Pedagogical Day at FARMA 2011
All rights reserved by David Needham
Biomineralization. ME265 Spring 2005
• Today we are going to cover
• With letters and numbers that really don’t mean much• But… what if we UNCOVERED precipitation by doing an • Experiment• …and Discovered Precipitation in the lab?
precipitationNa2CO3 + CaCl2 = 2NaCl + CaCO3
Precipitation of Calcium Carbonate
RhombohedralCalcite
Spherical Vaterite
5 minutes after mixing
40 minutes after mixing.Bar =10μm
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Solution A
Solution B
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“Our second-worst assumption as teachers is that if we don't cover something in class the students won't learn it.
Our worst assumption is that if we do, they will”.
Richard Felder, NCSU, "Nobody Asked Me, But..."Chem. Engr. Education, 23(1), 26-27 (Winter 1989).
Active and Cooperative Learning
http://www.youtube.com/watch?v=1J1URbdisYE
…and speaking of covering something….
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And so was born…. EDU-KWould students learn and retain more if we “taught” less? and they Experimented, Discovered and Uncovered more?
Explore Precipitation by a cycle of:• Experiment• Discovery• Uncovery• Knowledge• Experiment• Discovery• Uncovery• Knowledge• Experiment……
Pratt School of EngineeringProgress Report 2003-2004
Labs, design studios, machine shops, independent study..
Labs with Associated Classes!
How much of the material presented is actually learned?Especially when our environment is just a classroom?
I asked professors: “20%”I asked students in class:“20%”One kid at the back said “10!”
?
Even Virtual Labs!
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Map Engineering on to Biology?
What would we get?
?
Section I Introduction to Engineering Ch 1-6Section II Mathematics Ch 7-9Section III Engineering Fundamentals Ch 10-16Section IV Engineering Accounting Ch 17-24
Chapter 1 Science and Evolution Part I The Chemical and Cellular Basis of Life Ch 2-7Part II The Perpetuation of Life Ch 8-16 Part III Evolutionary Biology Ch17, 18Part IV The Genesis and Diversity of Organisms Ch 19-25 Part V The Biology of Organisms Ch 26-38Part VI Ecology Ch 39,40(Gould and Keeton, W. W. Norton & Company)
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Traditional New Way
Core Content
Content Framework
Teaching Pedagogy
EDU-K Learning-centric Pedagogy
SUMMARY: Four Key Components
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Or we might think of it in these terms……
PEDAGOGY CONTENT FRAMEWORK TOOLS OUTCOMES
EDU-K Hierarchical Problem
Design Methodology
Lecture at Home,
Homework in Class
Novice to Expert
Emotional Journey
Invention
Motivational Journey
PEDAGOGY CONTENT TOOLSFRAMEWORK OUTCOMES
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• The 3-year bachelor’s programme confers the right to use the title BSc in Pharmacy, is a fully integrated pharmaceutical-oriented programme with courses in the disciplines of chemistry, pharmacology and pharmaceutics
In Class
In Labs
Outside
In Internships
Then I came to….
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Pharmacy Curriculum, BSc + MSc = 5yrs
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3 yr BSc
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3rd Year
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…. Fall semester
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Drug Formulations CourseDrug Delivery F23-1
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Table showing the lectures in theme III Table showing the lectures in theme III
Date Time Tema Title og references for reading Forelæser(e)
31.10.11 14:00-14:05
14:05-14:45
15:00-15:45.
3 Introduktion til Tema 3 Introduction to theme III
FLYDENDE LÆGEMIDLER I (Liquid formulations I) FLYDENDE LÆGEMIDLER II
JEJA
BDS
BDS
07.11.11 14:00-15:45
3 Halvfaste formuleringer Semisolid formulations (salver, geler, cremer mm.)
SB
07.11.11 15:00-15:45 3 Afgift fra halvfaste formuleringer Release form semi-solid formulations
CUN
14.11.11 14:00-14:45 3 Faste formuleringer Solid formulations
JEJA
14.11.11 15:00-15:45 3 Faste formuleringer med modificeret frigivelse Soldi formulations with modified release
JEJA
15.11.11 13:00-13:45 3
Formulering af peptider og proteiner Formulation of peptide and proteins
LEJ
15.11.11 14:00-14:45 3 Avancerede formuleringer I – Polymere drug delivery systemer Advanced formulations I – polymeric delivery systems
YHW
21.11.11 14:00-14:45 3 Avancerede formuleringer II – lipidbaserede drug delivery systemer – liposomer Advanced formulations II – lipid-based drug delivery systems - liposomes
CF
22.11.11 13:00-13:45 3 Avancerede formuleringer III – vacciner og nukleinsyre-baserede lægemidler Advanced formulations III – vaccines and nucleic acid – based drugs
HMN
24.11.11 14:00-14:45 3
Formulering af tungtopløselige lægemiddelstoffer Formulation of low soluble drugs
LHN og AMU
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Lecture on….. 6.2 Colloid Stability
• Fine Particles in a liquid or gas encounters occur due to:– Brownian Motion
• random motion of particles– Creaming of Sediment
• O/W emulsion: Oil droplets move up or • W/O emulsion: water droplets move down
– Convection
How do you reduce creaming?
• Smaller particles• Increase viscosity• Decrease density difference• ??
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What is the fate of particles when they come into contact?
• Permanent contact or coalescence– Growth of dispersed phase, – excessive creaming or sedimentation
• Leads to cracking of the emulsion
• Balance of attractive and repulsive forces?
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Forces of Interaction Between Particles
• Five possible forces between colloidal particles1. Electrostatic forces of repulsion2. Van der Waals forces of attraction3. Born Forces of short range repulsion4. Steric forces at the interface5. Solvation forces due to adsorbed solvent
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van der Waals Attraction + Electrostatic Repulsion = DLVO
• When H/a is small (Large particles, semi infinite slabs)
R
H
a
Electrostatic Repulsive force decays as an exponential
• For small values of and exp (-kH):
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How do we go from….
This Because of… This
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To….
Something like…. This
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About 3,420,000 results (0.08 seconds)
6.2 Colloid Stability
• Fine Particles in a liquid or gas encounters occur due to:– Brownian Motion– Creaming of Sediment– Convection
http://www.youtube.com/watch?v=cDcprgWiQEY&feature=related
http://new.americanlaboratory.com/913-Technical-Articles/35127-Measuring-Yield-Stress/ http://www.youtube.com/watch?v=7xWWowXtuvA
We….. And found…..
All rights reserved by David Needhamhttp://www.malvern.com/LabEng/industry/colloids/colloids_stability.htm
Or… find other web sites, (many companies describe basic science for us to understand how to use their instruments or chemical products…)
All rights reserved by David Needhamhttp://www.malvern.com/LabEng/industry/colloids/dlvo_theory.htm
……. And even our own lecture…..
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……. And even our own lecture…..
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…. And descriptions of the instruments our students use in the lab
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… or use other bone fide resources like the Royal Society of Chemistry
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….and more pictures and diagrams ….
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…and even other professors teaching the same thing in cool ways….
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In the old days…..• they really needed us to explain the book,• But now…. 10 years AG• Students can Explore, and find all this, and Discover it for
themselves (with some guidance and Uncovery of principles from us)
• Leading to their new Knowledge
(Anno Google)
EDU-K
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So,…. could we even go to ….
This…
“Teaching at” “Facilitating the learning of”
“guide by the side”
is replaced by…
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By deeper planning than simply leading students through a classroom behavior
i.e., going further…
• And integrating active learning with core content leading to core competency?
http://ctl.byu.edu/teaching-tips/active-learning-techniques
We need to do both!!
Passive Teaching
Hmmm, so we can reduce creaming by making smaller particles, or increasing viscosity, or decreasing density difference, or doing it on the moon!! Ha, Ha!
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Passive Learning
• Lecture at Home?
Could we do…….
http://www.techsmith.com/camtasia.asp
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Active Learning
• Lecture at Home• ……………………………... Homework in Class?
What about…….
But what would we actually do in the
classroom if all the lectures were recorded?
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Reverse Engineer Problems Pharmacists Solved?
Designing
Formulating
Advising
Dispensing
Caring
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What the class room (U23) looks like now ….Reverse Engineering a Problem Pharmacists Solved
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So…, What is Reverse Engineering?
• A design methodology scheme that will allow us to ask additional specific questions in order to reverse engineer the overall system, its supply and its target
• Actually, why don’t you see if you can come up with a design scheme yourselves.
• What questions would you want to ask in order to learn as much as you can (reverse engineer) a simple cup. Write down all the questions you might want answered, I’ll start you off,
• “What is it made of?”
(check your answers on the next slide)
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Check your answers here
• What is it for? • How should it work?• What is it made of?• What are the characteristics of the material?• How is it made?• Has anybody made something similar?• Does it really work?
Tillykke!! You just reverse engineered a plastic cup!
The idea is to now apply this same series of questions to a system YOU are interested in, like……….
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Drug Delivery F23-1 (Jette Jacobsen and Staff)Theme 3 -a Course Enhancement Project
• Introduction to Reverse Engineering Problems Pharmacists Solved – (Lecture recorded and provided to F23-1 students)
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How did Pharmacists Solve the “Morphine Delivery” Problem?
With Patient controlled analgesic (PCA) metered system using i.v. injection
With Metered epiduralWith Skin patchWith Oral tablet formWith OintmentsWith Suppository
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Group Assignments
Sign Up in groups of 4-5 by Monday 7th Nov
GROUP 1 Topic Names
A) PCA 1_______________________________________ 2 _______________________________________ 3 _______________________________________ 4 _______________________________________ 5 _______________________________________
B) Epidural 1_______________________________________ 2 _______________________________________ 3 _______________________________________ 4 _______________________________________ 5 _______________________________________
C) Skin Patch 1_______________________________________ 2 _______________________________________ 3 _______________________________________ 4 _______________________________________ 5 _______________________________________
D) Ointment 1_______________________________________ 2 _______________________________________ 3 _______________________________________ 4 _______________________________________ 5 _______________________________________
E) Tablet 1_______________________________________ 2 _______________________________________ 3 _______________________________________ 4 _______________________________________ 5 _______________________________________
F) Suppository 1_______________________________________ 2 _______________________________________ 3 _______________________________________ 4 _______________________________________ 5 _______________________________________
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1. How did Pharmacists Solve the “Morphine Delivery” Problem?
With Patient controlled analgesic (PCA) metered system using i.v. injection
Title, slide 1
Frederik CristofferSofie Mathilde
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Overall System
• Morphine is supplied to the blood stream from a device called patient controlled analgesia, (PCA) via an intravenous injection.
• Its target is the pain center in the brain. Toxicity can include……
Supply Target
PCA Intravenous injection Pain Center in the Brain
Morphine
Overall System, slide 2
Sites for Toxicity?
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Performance in Service
43
Design methodology Scheme we will work through
Define the function Device to give i.v. fluids
Material Selection Component Design
Tentative component design
Approximate stress analysis
Tentative choice of material
Assemble Materials Data
Analysis of Materials Performanceiterate
Detailed Specifications and Design
Choice of Production Methods
Prototype Testing
Performance in Service
Further Development
iterate
iterateiterate
LAWS
3
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What is it for? How should it work?What is it made of?
What are the characteristics of the material?How is it made?
Has anybody made something similar?Does it really work?
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Performance-in-Service
• Describe the clinical data that quantifies its performance• web, books, journals, your class notes, your professor(s))• Be quantitative e.g.,
– mls solution per minute, – mass drug per mass of patient, – etc
Performance-in-Service, slide 3 How does the Morphine delivery System perform in service? --quantify
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Define the Function
The Function of the (PCA) Morphine Delivery System is to:a)b)c)d)
Define the Function, slide 4 What is the function of the (PCA) Morphine delivery System?
to dissolve morphine in liquid solution
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Laws, Theories, ModelsThe Laws, Theories, and Models of the PCA Morphine Delivery System that
correspond to each Function are :
Laws, Theories, Models, slide 5 What are the Laws, Theories, and Models of the (PCA) Morphine Delivery System that correspond to each Function ?
Function Law, Theory, Model
a) to dissolve morphine in liquid solution
Concentration of Morphine
b)
c)
d)
.
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Component Design
Component Design slide 6 What are the basic components of the Morphine
Delivery System?
What are the environmental stresses on the delivery and its individual components in service?
What does the design look like?
1. Saddle, seat2. Crossbar3. Gearshift4. Handlebars5. Brake cable6. Brake lever7. Front brake8. Rim
9. Tire10. Crank11. Pedal12. Front derailleur13. Chain14. Rear derailleur15. Spokes16. Rear brake17. Pump
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Materials ChoiceComponent Composition Structure Property Saddle, seat:
Rails PanPadCover
SteelHDPE plasticPoly urethane cellulose
FCCSemi-crystalline polymerfoamWoven fiber
200 GPa4 GPa0.01 GPa35 GPa
2. Crossbar
3. Gearshift
4. Handlebars
5. Brake cable
6. Brake lever
7. Front brake
8. Rim
9. Tire
10. Crank
Materials Choice, slide 7 What materials are the components of the Morphine delivery system made from (assemble materials data CSP)?
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Analysis of Material’s Performance• Start by looking at the mechanism proposed in slide 6, and the properties
of a material component in slide 7, and try to connect the two in terms of how the device has to function (slide 4), given the laws (slide 5) that govern its function
• Concentrate on the – tubing of the i.v., and epidural, – or the protective layer and adhesive of the skin patch, – or the binders of the tablet– or the oil of an ointment– or the fatty material of the suppository
Analysis of Material’s Performance, slide 8
Can the materials bear the loads, moments concentration stresses etc., without deflecting too much, collapsing, or
failing in some other way?
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Specification Sheet (FDA)
For Traditional Engineering:http://www.shure.com/americas/products/microphones/sm/sm58-vocal-microphone
For Pharmaceuticals:European Medicines Agency (Europe): www.ema.europa.eu/ Food and Drug Administration (USA): www.fda.gov Drugs.com: www.Drugs.com
Search for your formulation and see how some of what you have already found out is an integral part of the FDA approval,
For example see http://www.drugs.com/pro/morphine-injection.html
Specification Sheet, slide 9
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Production
How are the various components of your morphine delivery system in fact made?
Plastic tubes and needles of the i.v. and epidural systems, orthe porous membrane or outer covering of the transdermal patchthe sintering of tablets,the emulsification of oilsthe molding of a suppository
Production, slide 10 How is the morphine delivery system be made from these materials? What is the size of the production run? How will the components be
finished and joined to other components; What does it cost?”
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PrototypesSearch for your device at:US patent and trademark office http://www.uspto.gov orEuropean patent office http://www.epo.org/ Free patents on line http://www.freepatentsonline.com/ For example you might search and find:• United States Patent 6,054,584, Process for Extracting and Purifying
Morphine From Opium, April 25, 2000• Or Cocaine-Laced Toothache Remedy Ad Targeted Children in 1885!
Prototypes, slide 11 At what point in the evolution and development of this particular morphine delivery device did a delivery system appear that could (your function statement here) …and thereby confer an advantage
on pharmaceutical drug delivery?
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This is your chance to get inventive! I bet you all have ideas now!
Further Development
Further Development , slide 12
Did any of this stimulate a new idea, concept, device or process or a way to improve or fix any failures of the current system?
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Target --the pain center in the brain
• We can also apply this reverse engineering scheme to understand more about the physiology, cell biology and molecular biology of pain control by going through the same scheme, but this time for the brain and pain!
Reverse Engineer Nature’s designs!
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What Some of Your Students Have Been Doing
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1. How did Pharmacists Solve the “Morphine Delivery” Problem?
With Ointments
Title, slide 1
Bahar ThomasLasse Julia
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Overall System
• Morphine is supplied to the skin through the ointment, with topical application.• Its target is opioid receptor in the nerves in the skin. Toxicity for this route can
include physical and psychical withdrawal, and allergic reaction.
Supply Target
Pain Center in the Brain
Morphine
Overall System, slide 2
Sites for Toxicity?
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Performance-in-Service
Performance-in-Service, slide 3
2 3 4 5 6 7 8 9 10 11 120
0.02
0.04
0.06
0.08
0.1
0.12
0.14
f(x) = 0.013199986286481 x − 0.0206772574833738R² = 0.996051345562709
Butylnicotinat ointment release
(time) [min]
Q(a
mou
nt re
leas
ed) [
µmol
/cm
2]
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Define the Function
The Function of the Morphine Delivery System is to:a) Deliver morphine transdermally to the local nervesb) Enhance penetrationc) Stabilize morphined) Enhance release from the ointment
Define the Function, slide 4
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Laws, Theories, ModelsThe Laws, Theories, and Models of the Morphine Delivery System that
correspond to each Function are :
Laws, Theories, Models, slide 5
Function Law, Theory, Model
a) Deliver morphine transdermally
b) Enhance penetration Occlusive effect, greater area, greater concentration, nonionic molecule
c) Stabilize morphine Prodrug, Protein binding
d) Enhance release from the ointment
Solubility: log(P)=log(Co/Cv)
.
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Component Design
Component Design slide 6
• The dosing media– Dosing tube covered with foil to reflect heat
• The formulation– (1) Morphine hydrochloride– (2) Glycerol (86 %)– (3) Rokacet R-70 (Polyoxyethylen esters of fatte acid)– (4) Methylparaben(pressavative)
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Materials ChoiceComponent Composition Structure Property 1. Morphine chloride C17H20NO3
+-Cl- MW: 311,2 g/molSolubility: 60 mg/ml ved 20T½: 2-3 hoursLog(P) = 0,89Log(D) = -0,07 (pH 7,4)Pka = 8,2Weak baseMelting Point: 200oCLD50= 120-250 mg
2. Glycerol C3H8O3 MW: 92,9 g/molViscosity: 1,412 Pas
3. Rokacet R-70 (date from R-40, due to lack of information avalable)
See below MW: 4190 g/molSolidification: 20 oCSolubility in water: GoodPale yellowDensity: 1,04 g/ml
4. Methylparaben C8H8O3 MW: 152,15 g/molSolubility: 20 mg/mlLog(P): 1,95
Materials Choice, slide 7
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Analysis of Material’s Performance• Morphine
– Small molecule MW < 500 = good permeability – Log(P) < 5 = good permeability
• Rokacet R-70– Enhance viscosity, and make the formulation useful as a hydrophilic ointment
• Glycerol– Enhance viscosity and solubility because of the three hydroxy-group
• Methylparaben (preservative)– Water soluble up to 0,2% which is enough, because the normally used conc. Is 0,1
%.
Analysis of Material’s Performance, slide 8
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Analysis of Material’s Performance
Analysis of Material’s Performance, slide 8
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Specification Sheet (FDA)
• You should not drink alcohol while using Morphine.
• SIde effects of Morphine include:- constipation, nausea, sleepiness, lightheadedness, dizziness etc.
• Morphine can cause serious breathing problems that can become life-threatening
• Morphine can cause your blood pressure to drop.
• Morphine can cause physical dependence.
• Take Morphine exactly as prescribed by your healthcare provider.
• Lethal dose is 120-250 mg/kg
Specification Sheet, slide 9
.
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Production
Production, slide 10
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Prototypes
• In the old Egypt extract from the opium valmue, was used as a sleeping agent and treatment of diarrhea
• Friedrich Serürner was the first to isolate morphine form the plant opium (1804)
• Around 1800 opium was used by the English people to blackmail China. The English people wanted the Chinese porcelain, but their would not sell it. Therefore England gave them opium and the Chinese became addicted and was force to sell their porcelain to England for opium.
• After the invention of the hypodermic needle in 1857 the alkoid became more widely used.
Prototypes, slide 11
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1. What is the most efficacious opioid and/or combination of ingredients and their dosages?
2. What is the most advantageous carrier (eg, gel, cream, lotion, DMSO, etc.) and method of application?
3. Which pain conditions are most amenable to topical opioid therapy?4. What degree and duration of analgesic effects might be expected?5. In which circumstances could topical opioids completely replace the need
for systemic opioids or other analgesics?6. What is the potential, if any, for developing tolerance or hyperalgesia
during prolonged use of topical opioids?
http://updates.pain-topics.org/2011/01/is-there-role-for-topical-opioids-in.html
Further Development
Further Development , slide 12
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A Summary of the “New Way”
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Traditional New Way
Core Content
Content Framework
Teaching Pedagogy
EDU-K Learning-centric Pedagogy
SUMMARY: Four Key Components
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= Intellectual content in context
EDU-K(Includes Teaching via
recorded lectures)
Content Framework of Design+ +
Macro - micro - nano
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Also, …. Emotional, and Motivational Journey of Life-Long Learners
Adapted from John Counsel’s www.profit.com Richard Ryan and Edward DeciAm Psychol. 2000 Jan;55(1):68-78
AutonomyRelatednessCompetency
Emotional Journey Motivational Journey
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So,…. Why do we/you want to put new Knowledge in your head anyway?
Invention Generator
KNOWLEDGE
IQ
KNOWLEDGE
IQ
oversimplified schematic of your “IQ” sitting over all the Knowledge you have acquired.
EDU- K
OUTCOMES: Invention Generator
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Evaluate How a Student Sees a Situation: as a Novice or as an Expert?
Stuart and Hubert Dreyfus 1977-1982
Self-Evaluation by my First Year Grad Student
OUTCOMES: Novice to Expert
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A Dean’s plea…..
• “We are asked to produce students who can work on problems in the pharmacy industry 15 -20 years from now. But how are we expected to know what they will be?” Sven Frøkjær, Dean KU Pharmacy School
• “So let’s train students to solve problems, and they will be able to solve any problem in that industry”, was my reply.
• EDU-K + Reverse Engineering + Hierarchical Scales + Lecture at Home Homework in Class + Emotional Journey + Motivational Journey + ……………….. YOUR input here, TOGETHER….
• = Competent Problem Solvers and Critical Thinkers