The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

CLOT

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie CLOT

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

aa

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

aa

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

a

aa

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

a

aa

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

a

aa

INTRINSIC PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

a

aa

INTRINSIC PATHWAY

EXTRINSIC

PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

a

aa

INTRINSIC PATHWAY

aBinds to, VII allowing activation

EXTRINSIC

PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

a

aa

INTRINSIC PATHWAY

aBinds to, VII allowing activation

Factor Xa inhibitorsDonn-Apixaban

Martharin (Heparin)River-oxaban

EXTRINSIC

PATHWAY

The Doctor whoClotting cascade

Based on the similar work of Dr Keir Shiels

Photos From the BBC (hope they don’t mind)

Release of T

issue F

actor (Factor III) from

dam

aged tissuie

Release of negative

ions from E

pithelium

Dam

age

CLOT

a

a

a

aa

INTRINSIC PATHWAY

aBinds to, VII allowing activation

Heparin also inhibits Thrombin

Da-Jamie-gatranThrombin inhibitor

Factor Xa inhibitorsDonn-Apixaban

Martharin (Heparin)River-oxaban

EXTRINSIC

PATHWAY