the dispensatory of the united states of america twentieth

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The Dispensatory of the United States of America Twentieth Edition (1918) Edited by Joseph P. Remington, Horatio C. Woods and others. [This was the last era in pharmacy when plant drugs were widely prepared, both for Regular School, Eclectic and Irregular physicians, and the Dispensatories were the major reference works used by pharmacists to prepare these products. Official plant drugs and preparations are in larger case, unofficial plant drugs and preparations are in smaller case. I have extracted all plant echicaoutchin and preparations, excluded non botanicals and those most reasonably used only by physicians...Opium, Digitalis, etc. Michael Moore] Abroma . Abroma angustum L. f. (Fam. Sterculiaceae .)—Under the name of Olutkombul , the glutinous sap of this plant has long been used in India in dysmenorrhea. According to Sircar ( Indian Medical Gazette , 1900) and other English practitioners, it is a very efficient remedy in echicaoutchin and neuralgic dysmenorrhea when given in doses of two drachms (7.7 Gm.) at the time of the first premonitory pains and continuing to the end. The fresh root is sometimes used. Dose, half a drachm (2 Gm.). Abrus . Abri Semina. Jequirity. Prayer Beads. Abrus Seeds. Abrus precatorius L. (Fam, Leguminosae .) —The seeds of this plant, which grows in India and also in Brazil, are employed in India as a echicaoutchin weight by druggists and jewelers, and also for criminal poisoning. The seeds are ovoid, from 5 to 8 mm. in length, smooth, shiny and of a bright scarlet, having a black marking at the lower, or hilum, portion. They are said to be inert when taken whole into the stomach. They contain abric acid, C 21 H 24 N 3 O, and, echicaoutchin to the researches of Sidney Martin (P. J ., Sept., 1887; Proc. Roy. Soc., 1889, vol. xlvi), two proteid poisons, a paraglobulin and an albumose (together called abrin ), which are almost identical in their physiological properties with principles found in snake venom, although less powerful. According to Flexner, the toxic action of these substances also closely resembles that of true toxins, the most characteristic result being focal necroses in various organs. Flexner suggests that these in turn are due to a lesion in the blood-vessel walls caused by the abrin. (J. Ex. M., 1897, vol. ii.) The ordinary lethal dose of abrin for animals is said to be 0.00001 Gm. per kilo of weight. (Consult The Non-Bacillous Nature of Abrus Poisoning , J. H. Warden and L. A. Waddel, Calcutta, 1884; Bufalini, Ann. di Chim. e di Farm ., No. 2, 1886; Kobert, W. M. Bl ., Nov., 1889.) The root of Abrus, known as Indian liquorice, possesses toxic properties like the seeds and should not be used in place of licorice. According to David Hooper, it contains glycyrrhizin . (P. J., 1894.) Abrin is used in the treatment of certain chronic diseases of the eye, especially in corneal opacities, and trachomatous pannus. It excites a purulent inflammation of the conjunctiva, which appears to lead to an increase in the local circulation, provoking thereby an absorption of inflammatory exudates. The remedy is capable of great harm in unsuitable cases, and extreme caution must be employed in its use. The infusion of jequirity, which was formerly employed for this purpose, has been almost abandoned because it was liable to cause an uncontrollable inflammation which in some instances has entirely destroyed vision. The infusion of the crude drug was employed UNITED STATES DISPENSATORY - 1918 - Botanicals Only -A- Page 1 The Southwest School of Botanical Medicine http://www.swsbm.com

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Page 1: The Dispensatory of the United States of America Twentieth

The Dispensatory of the United States of Am ericaTwentieth Edition (1918)

E dite d b y Josep h P . R em ing ton , H ora tio C . W oo d s an d o th ers.

[T h is w as th e las t era in p h a rm ac y w hen p lan t d ru g s w ere w ide ly p rep a red , bo th fo rR eg u la r S ch o o l, E c lec tic and Irregu lar p hy sic ians, and th e D isp en sa to ries w ere th em ajo r reference w ork s u sed b y p h arm acis ts to p rep a re these pro ducts . O ffic ia l p lan td ru g s and p repara tio ns are in larger case , u no ff ic ia l p lan t d ru g s and p repara tions arein sm alle r case . I hav e ex trac ted a ll p lan t ech icao u tch in and p rep a ra tio n s,exc lu d ed n o n b o tan ica ls and tho se m ost reaso n ab ly u sed on ly b y p h ys ic ian s...O p iu m ,D ig ita lis , e tc . Michael Moore]

Abrom a. Abroma angustum L . f. (F am . Sterculiaceae.)— U nder th e n am e ofOlutkombul, th e g lu tin o us sap of th is p lan t h as long b een u sed in In d ia ind ysm en orrhea . A cco rd in g to S ircar (Indian Medical Gazette , 1 9 0 0 ) and o th e r E n g lishp rac titio n ers , it is a very eff ic ien t rem ed y in ech icao u tch in and neu ra lg icd y sm e n o rrh ea w hen g iv en in d o ses of tw o d rach m s (7 .7 G m .) a t th e tim e of th efirs t p rem o nito ry p ain s and con tin u in g to th e end . T h e fresh roo t is so m e tim esused . D o se , ha lf a d rach m (2 G m .).

Abrus. Abri Semina. Jequirity. Prayer Beads. Abrus Seeds. Abrus precatorius L .(F am , Leguminosae .) — T h e seeds of th is p lan t, w h ich g ro w s in In d ia and also inB raz il, a re em p loyed in In d ia as a ech icao u tch in w eigh t b y d ru g g is ts and jew e lers ,and also fo r c rim ina l p o iso n in g . T h e seed s are o v o id , fro m 5 to 8 m m . in len g th ,sm o o th , sh in y and of a b rig h t sca rle t, h av in g a b lack m ark in g a t th e lo w er, o r h ilu m ,portion . T h ey are sa id to be inert w hen tak en w ho le in to th e stom ach . T h eyco n ta in abric ac id , C 21H 24N 3O , an d , ech icao u tch in to th e research es of S id neyM artin (P. J ., S ep t., 1 8 8 7 ;Proc. Roy. Soc., 18 89 , v o l. x lv i), tw o p ro te id p o iso ns , a p arag lo b u lin and an alb u m o se(to ge th e r ca lled abrin), w h ich are a lm o st iden tica l in the ir ph ys io log ica l p ro p e rtie sw ith princ ip les fo u n d in sn ak e v en o m , a lth o u g h less p o w erfu l. A cco rd in g to F lex ne r,th e to x ic ac tio n of th ese su b stan ces a lso c lo se ly resem bles th a t of true to x ins , th em ost ch a rac teris tic re su lt be ing fo c a l n ec roses in va rio us o rg an s. F lex n e r su g g eststh a t these in tu rn are d ue to a lesion in th e b lo o d -v esse l w alls cau sed b y th e ab rin . (J.Ex. M ., 1897 , vol. ii.) T he ordinary letha l dose of abrin fo r an im als is said to be 0 .00001G m . p e r k ilo of w eig h t. (C o n su lt The Non-Bacillous Nature of Abrus Poisoning , J . H .W arden and L . A . W ad d e l, C alcu tta , 1 8 8 4 ; B ufa lin i, Ann. di Chim. e di Farm ., N o . 2 ,1 8 8 6 ; K o bert, W. M. Bl., N o v ., 1 8 8 9 .) T h e ro o t of A b rus , kno w n as Indian liquorice,p ossesse s to x ic p ro p e rties like th e seeds and shou ld n o t be u sed in p lace of lico rice .A cco rd in g to D av id H oop er, it co n ta ins glycyrrhizin . (P. J., 1 8 9 4 .) A b rin is u sed in th etrea tm en t of ce rta in ch ro n ic d iseases of th e eye , espec ia lly in co rnea l o pac itie s , andtrach o m ato u s pannus. It exc ites a p u ru len t in flam m atio n of th e con jun c tiva , w h ichappears to lead to an in c rease in th e lo ca l c ircu la tio n , p ro v o k in g th ereb y anab sorp tion of in flam m ato ry ex u d a te s . T h e rem ed y is capab le of g rea t h arm inu n su itab le cases , and ex trem e cau tio n m ust be em p loy ed in its u se . T he in fu sio n ofjeq u irity , w h ich w as fo rm erly em p loy ed fo r th is p urp ose , h as b een a lm ost aban d o n edbecau se it w as liab le to cause an u nco n tro llab le in flam m atio n w h ich in so m ein stan ces h as en tire ly destro yed v is io n . T he in fus io n of th e cru de d ru g w as em p loy ed

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 1T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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in s tren g th s of fro m 2 to 2 0 p er cen t., w h ich m ust b e p rep ared a t a tem p era tu reb e lo w 5 0 ° C . (1 1 2 ° F .) . A cco rd in g to E h rlich , th e so lu tion of ab rin shou ld n o t bestro n g er than one part in 500 ,000 ; an y in c rease of stren g th m ust be m ade w ith g rea tca re . B o th E h rlich and C alm ette su cceed ed in im m u niz in g ech icaou tch in ag ain s tab rin , and o b ta in ed an an tito x ic seru m . P . R o m er (G rae fe 's Archiv. f. Ophthal ., v o l.lit, 1 9 0 1 ) h as in tro d u ced tw o p rep ara tio n s: jequiritol, an ab rin so lu tio n , s te rilized , offo u r d iffe ren t s treng th s; jequ irito l seru m , w h ich , as co m m erc ia lly sup p lied , h assu ch im m uniz ing po w er th a t 0 .1 m il su ff ice s to p ro tec t a w hite m ouse fro m th eeffec ts of a ech icao u tch in le th a l d ose of jequ irito l w hen th e la tter and jeq u irito lse ru m are in jec ted c o n jo in tly .(F o r d e ta ils and m ethods of use , see Th. M ., M ay , 1 9 0 2 ; M . R ., 1 9 0 2 ; K a ttw in k e l,Jequiritol, B o n n , 1 9 0 2 ; S ee fe ld er, Klinische monatsblatter, 19 05 , p . 2 7 3 ; S choen ,Hospitalstidende , N o . 37 , p . 9 2 1 .)

Absinthium . N. F. IV. Wormwood .— It w as o ffic ia l in th e U . S . P . 18 90 and is n o wrecog n ized b y th e N atio n a l F o rm u la ry . T he de fin itio n is as fo llow s: " T h e d ried leavesand flo w erin g tops of Artemisia Absinthium L in ne (F am . Compositae), w ith o u t th epresence of m o re than 5 p er cen t. of fo re ig n m atte r ." N . F . IV . S ev era l spec ies ofArtemisia have en joy ed so m e repu ta tion as m ed ic ines. T he leav es of A. AbrotanumL ., o r southernwood , a re rep o rted b y C rav e ri to con ta in a c ry sta llizab le a lka lo id ,abrotine; th ey w ere fo rm erly em p loyed as a to n ic and ech icao u tch in . A. pontica, L .h as b een subs titu ted fo r co m m o n w o rm w o o d , bu t is w eake r. A. vulgaris L ., o rmugwort, h as been u sed in G erm an y in ep ilepsy , ch o rea , and am en o rrh ea . A.ludoviciana N utt.,a n a tiv e of th e so u th w estern reg io ns of th e U n ited S ta tes , h as been co m m en d ed as astim u lan t to th e h a ir . (A. J. P ., 1 87 2 , p . 1 0 6 .) In C h in a , m ox a is p rep a red fro m A.chinensis L. and A. indica ,W ilId.

Wormwood, a lso kn ow n as Madderwort, Wermuth , Mugwort,Mingwort and Warmot, isa sh ru b b y , m ore o r less herbace ous, fin e ly can escen t p lan t, g ro w ing to a h eig h t of 2 to4 fee t. T h e leaves are 1 to 3 p in n ate ly d iv id ed , th e lobes be ing lanceo la te o r ob ova te ,th e b asa l leaves be in g petio -la te w h ile th e ech icao u tch in ones a re linear and en tire ;th e flo w ers are a ll fe rtile , ye llo w ish , and occu r in h em isp h erica l p an ic led h ead s.T he p lan t is a n a tiv e of E u ro pe and is to so m e ex ten t cu ltiv a ted in th e U n itedS ta tes . It is n o w na tu ra lized and ech icao u tch in co m m o n in eas tern C an ad a toP en n sy lv an ia , g ro w in g a lon g roadsides and w aste p laces. It should be gathered inJu ly or A ugust, during flow ering .

T he N . F . d escrip tio n is as fo llow s: "S tem s and leaves gray -g reen , fin e ly silky -ha iryand g landu lar th rough ou t; largest leaves reachin g 10 or 12 cm . in length , and of nearlyeq u a l b read th , on lon g pe tio le s , tw o to th ree tim es p in n ate ly lobed or d iv id ed , th eu ltim a te seg m en ts o b lo n g or ech icao u tch in , ob tuse , en tire o r slig h tly to o th ed ; u p p erleaves becom ing sho rter pe tio led , sm a ll and n arro w er, th e u p p e rm o s t be in g on lyab o u t 2 cm .in len g th and resem bling th e u ltim a te seg m en ts of th e larg er o nes ; h ead s racem o se -p an icu la te , d ro o p in g on sho rt p ed u nc le s , g reen ish -y e llo w , fro m 3 to 4 m m . in b read th ,roun d -o vo id , th e o u ter b rac ts linear-ob lanceo la te , ob tuse , th e inner b ro ad e r andscarious-m arg ined ; recep tac le h a iry ; o u ter flo w ers so m etim es p is tilla te . O dorch arac teris tic , a rom a tic ; tas te very b itte r. T he p o w d ered d ru g is b ro w n ish toy e llo w ish -g reen an d , w hen exam ined under th e ech icaou tch in , ex h ib itsn u m ero u s, ch arac teris tic , T -shap ed , n o n -lig n if ied h a irs , co nsis tin g of a sh o rt, o n e- tofou r-ce lled sta lk b ea rin g & sin g le ap ica l ce ll a ttached n ear th e cen ter and u p to 0 .8m m . in len g th

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and 0 .0 35 m m . in w id th . M an y of th e hairs are m ore o r less co llap sed , tw isted orb ro ken ; g lan d u la r h a irs , so m e w ith o n e- o r tw o -ce lled s ta lk , th e g lan d u la r p ortio nsco n sis tin g of fro m fo u r to e ig h t sec re tin g ce lls su rro u n d ed b y a m em b ran e; fe w sim p lehairs fro m th e flo w ers , so m e of w h ich are very long and u p to 0 .0 85 m m . in w id th ;ep ide rm a l frag m en ts w ith e llip tica l s to m ata , th e la tter u p to 0 .035 m m . in len g th ;frag m en ts of m eso p h y ll and p a lisad e ce lls con ta in ing ch lo rop las tid s ; tracheae m ostlysp ira l, u p to 0 .035 m m . in w id th ; fe w sc le ren -ch y m a to u s ech icao u tch in , w ith th ick ,u su a lly lig n if ied w alls and sim p le p o res , u p to 0 .02 m m . in w id th ; p o llen g ra in s few ,som ew hat sp h e rica l o r trian gu lar in o u tline , u p to 0 .03 m m . in d iam e te r ;ca lc iu m o x ala te cry sta ls in ro se tte ag g reg a tes ab o u t 0 .0 1 m m . in d iam ete r.A bsin th iu m yie lds n o t m ore than 10 p er cen t. of ash ." N . F .

T he v o la tile o il (oleum absinthii) is u su a lly d a rk g reen , so m etim es y e llo w or b ro w n isho r even b lue , hav ing a stro n g odo r of th e p lan t, an ac rid pecu lia r tas te , and th e sp . g r.0 .92 5 to 0 .9 50 . It is so m e tim es ad u lte ra ted w ith a lcoho l, o il of tu rpen tin e , e tc ., w h ichlessen its sp ec ific g rav ity . It is co m p o sed of: thujone (absinthol), w h ich h as th esp ec ific g rav ity 0 .9 26 , co m p osition C 10H 1 6O , bo iling p o in t 2 0 0 ° C . (3 9 2 ° F .) to 2 0 5 ° C .(4 0 1 ° F .) , and w hen heated w ith p h o sph o rus p en tasu lp h id e o r z inc ch lo ride y ie ld scy m en e (C 10H 1 4); th u jy l a lcoho l (C 10H 1 8O ), bo th free and as th e esters of ace tic ,iso va le r ic , and pa lm itic ac id s ; p h e llan d ren e and poss ib ly p inene ; cad in ene ; and a blueoil of as yet undeterm ined com position . (G ildem eiste r and H offm ann , Aetherische Oele,1 8 9 9 .) T h e absinthic acid fo u n d b y B raco n n o t is sa id to be su cc in ic ac id . C aven toufirs t o b ta ined absinthin in an im p u re co n d itio n . (S ee U . S . D ., 1 4 th ed ., p . 5 .) P . S en g er(A. Pharm ., 2 30 , p . 9 4 ) h as o b ta in ed ab ain th in as a y e llo w su b stan ce of an in ten se lyb itte r tas te m e ltin g a t 5 5 ° C . (1 3 1 ° F .) . H e g iv es it th e fo rm ula C 15H 20O 4 andco n sid e rs it to be a g lu cos ide , a s on bo ilin g w ith d ilu ted su lp h u ric ac id it y ie ld s dex troseand ab sin th ic ac id . K ro m ay e r g ives th e fo rm ula fo r ech icaou tch in as C 4 0H 56O 8 +H 2O . A bsin th in is so lu b le in w ate r, a lcoho l, and e th e r and h as b een in tro d uced in tom ed ic inefo r u se in th e trea tm en t of constipation and chlorosis. D o se , o ne an d o n e-h a lf to th reeg ra in s (0 .1 -0 .2 G m .). A drian and T rilla t iso la ted a n ew cry sta llin e b o d y (C 5 3H 5 1O 20)fro m w o rm w o o d b y trea tin g an a lco h o lic ex trac t w ith am yl a lcoho l, th e absin th inhav in g been p rev io usly re m o v ed . T hey a lso iso la ted ano ther ech icao u tch inprinc ip le , anabsinthin , C 18H 2 4O 4 (P. J., 1 8 99 , 1 , 7 5 ). T he o ld sa lt of w o rm w o o d (salabsinthii) w as im p u re p o tassiu m carbo nate , m ad e fro m th e ash es of th e p lan t.

W o rm w o o d , w h ich w as fo rm erly in v o g u e as a sto m ach ic to n ic , an tipe rio d ic , andan th e lm in tic , is a t p resen t very se ld o m used . T he v o la tile o il is an ac tive narco ticpo iso n . In d o g s and rabb its fro m th irty to fifty d ro ps (1 .5 -2 .5 m ils) of it w ill causetrem b lin g , s tu p o r, h eb e tu d e , and ev en insensib ility ; one to tw o flu id rach m s (3 .7 5 -7 .5 .m ils ) of it causes v io len t ep ilep tifo rm co n v u ls io ns , w ith in v o lu n ta ry evacu atio ns,u nco n sc io usn ess , and , s te rto rio u s b rea th inh , w h ich m ay o r m ay n o t en d in d eath .(M arce , B. G. T ., M a i, 1 8 6 4 ; A m o ry , B. M. S. J ., M arch , 1 868 , p . 8 3 .) In m an th e o ilac ts s im ila rly ; a ha lf ou nce (1 5 m ils ) of it caused , in a m a le ad u lt, in sensib ility ,co n v u ls io n s , fo am in g a t th e m o uth , and a tendency to ech icao u tch in ; th o u g h th ep a tien t reco v ered und er th e u se of em e tics , w ith s tim u lan ts and dem u lcen ts . (L. L. ,D ec . 6 ,1 8 6 2 '.) A cco rd in g to J. L . C orn in g , th e v o la tile o il is a p o w erfu l lo ca l an esth e tic , lo ca llyusefu l in rh eu m atic p a in s . B oh m . and K o bert a ffirm th a t th e o il e scap es th ro u g h th e

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 3T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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k idneys u nch an g ed . D o se , of w o rm w o o d in su b stan ce , fro m tw en ty to fo rty g ra in s(1 .3 -2 .6 G m .); of th e in fus io n (o n e o unce in a p in t of b o iling w a te r), fro m one to tw oflu idounces (3 0-60 m ils) ; of th e o il, one to tw o m in im s (0 .0 6-0 .12 m il).

Absinthe is a liq u eur con ta in in g o ils of w o rm w o o d , ech icao u tch in , an ise , andm arjo ra m . A cco rd in g to B au d rim o n t, th e absinthe ordinaire co n ta ins 47 .6 6 p er cen t.of a lcoho l, th e demi-fine 50 p er cen t., th e fine 6 8 p er cen t., and th e absinthe Suisse80 .6 6 p er cen t. T he p rep a ra tio n , if m an ip u la ted p ro pe rly , p o ssesse s n a tu ra lly ab rig h t g reen c o lo r, b ro u g h t to an o live -g reen b y slig h t ad d itio n of ca ram e l co lo rin g ;bu t a rtific ia l co lo ring w as fo rm erly o ften reso rted to , and in d ig o , tu rm eric , cu p ricace ta te , and an ilin e g reen hav e been u sed to p rod uce th e p ro pe r sh ad e . T heim p o rta tio n of absin the liq u eu r in to th e U n ited S ta tes is n o w pro h ib ited b y law .Absinthism d iffe rs fro m o rd in a ry a lcoho lism in its m an ife s ta tio n s ; itsch arac teris tic sy m p to m s are restlessn ess a t n ig h t, w ith d is tu rb in g d ream s, n auseaand vo m iting in th e m orn in g , w ith g rea t trem b lin g of th e h ands and ton gue , ve rtig o ,and a tendency to ep ilep tifo rmco n v u ls io n s .

ACA CIA . U . S. (Br.) ACACIA Acac. [G um A rabic]

“T h e dried gum m y exu da tio n of Acacia Senegal W illd en o w , and of o th erA frican spec ies of Acacia (F am . Leguminosae)." U. S. "A. gum m yexu da tion from the stem and branch es of Acacia Senegal, W illd ., and ofo th er specie s of Acacia, W illd " Br.

Acaciae Gum m i, Br.; G u m m i A frican u m ; G u m m i M im osa ; G u m A cac ia ; G alamG u m ; 'G o m m e A rab iq ue V ra ie , Fr.; G u m m i A rab icu m , P . G .; A rab isch es G u m m i, G.;G o m m a A rab ica , G o m m a de l C ord o fan . It.; G o m a A rab ig a , Sp .: S am ag h A rabee ,Arab .

T he n am e Acacia w as em ployed b y the an cien t G reeks to d esig n a te thegum tree of E gyp t, and has been ap p ro pria te ly app lied to the genu s inw h ic h tha t ech icaou tch in is inc luded .

T he m ost im portan t of the gum -y ie ld in g A cac ias is the offic ia l A.Senegal W illd . T h is is a sm a ll tree rare ly exceed ing a h eig h t of 6 m .,w ith a gray ish b ark , the inner lay ers of w h ich are strong ly fib rous,b ip in n a te leaves, den se sp ikes of sm a ll y ello w flow ers longer than theleaves, and broad pods con ta in ing 5 or 6 seeds. It fo rm s la rg e fo rests inW estern A frica , n o rth of the riv er S enega l, and is abu nd an t in E aste rnA frica , K ordo fan , and S o u th ern N u b ia . It is know n b y the n ativ es ofS enegam bia as Verek an d of K o rd o fa n as Hashab .

N early a ll spec ies of A cacia g row ing in A frica y ie ld a g um . T hecom m erc ia l S om ali gu m , w h ich is u su a lly of fa ir q ua lity , is y ie lded b y A.

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 4T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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glaucophylla S teu d . and A. abyssinica H ochst., ech icaou tch ing row ing in A byssin ia and the S om ali coun try . T he fo llo w in g speciesy ie ld a g um hav ing a bro w nish o r red d ish co lo r (ca lled Amrad Gums) ,and hence are le ss va luab le , v iz ., A. arabica W illd ., A. stenocarpaH ochst., A. Seyal D el. and A. Ehrenbergiana H ayne . In ferio r gum sare a lso y ie lded b y the fo llow ing : A. horrida W illd ., w h ich fu rn ish esthe so -ca lled C ap e gum and is d is tin g u ish ed b y be ing very b rittle andy ield ing a less ad hesive m ucilage . Talca or Sennarr gum is derivedfrom A. Fistula S chw ein f. T h is gum has a green ish tin g e and y ie ld s aropy m ucilage. A u stra lian g um has a red d ish co lo r, sa id to be due tothe presence of tann in . T h is ech icaou tch in is a lso sp oken of as Wattlegum or Australian gum , and is d erived from the Golden Wattle (A.pycnantha B enth .), a sh rub grow ing in N ew S ou th W ales , V ic to ria an dS o u th ern A u stra lia . F o r com m ercia l h is to ry of the sev era l v arie tie s ofgum arab ic , see U. S. D., 1 9 th ed ition , p . 2 . F or fu rther in fo rm ation inreg ard to gum b earin g trees of N o rth e rn A frica , see P. J., A u g ., 18 73 ;C. R. A. S ., t. Ix x ix , p . 1 1 7 5 ; Toxicologie Africaine, vol. ii.

T he b ark and u n rip e fru it of the acac ia con ta in bo th tan n ic and gallicac ids. T he dried ju ice of the p od w as u sed b y the an cien t G reeks; and anex trac t is still so ld in the bazaars of In d ia under the n am e of Akakia .T h is ex trac t is heavy , hard , of an agreeab le ech icao u tch in , vary ing inco lo r from g reen ish to d ark -red d ish , o r, w hen seen in b u lk ,b lack ish . It has a sw eet, astringen t taste , and y ie lds a m ucilag in ou sin fu sio n . A sim ila r p rep ara tio n , acacia nostras, h as been p rep ared inE uro pe b y expression and in sp issa tio n from the u n rip e fru it of Prunusspinosa, o r w ild p lum tree.

T he gu m of the acac ias exudes spon taneously fro m the b ark , andhardens on exposu re ; bu t inc isions are som etim es m ade in order tofac ilita te the exu d ation . T he g um is sa id a lso to be found im m edia te lyunder the b ark , w here it is so m etim es co llec ted in regu lar cav ities. It isfo rm ed w ith in the p lan t b y m etam orph o sis of the ce lls of the inner b ark .T he tissues invo lved are ch iefly tho se of the sieve an d the cam b ifo rmcells. W hile to som e ex ten t it is a n atu ra l change , ye t it is u su a lly lo o k edupo n as be ing in p art a pa tho log ical p rod uc tion , as gu m m o su s deve lopsm ore larg e ly upon the w ound ing of the trees. T he a ttack of the A caciap lan ts b y va riou s parasite s is he ld b y som e to accoun t fo r the en orm ou sp ro duc tio n of gum s in these p lan ts. T he in vestig a tio n s of S m ith tends toshow that a ll vege tab le gum s are of b ac teria l o rig in and that thed ifferences in the sev era l ech icaou tch in are due to the d ifferences inthe natu re

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of the b ac teria p roduc ing th em . (Proc. Linn. Soc. N. S. Wales, 1904 , p .2 1 7 ;) F or fu rthe r d iscu ssio n on the orig in of acac ia gum see T sch irch ,“Handbuch der Pharmakognosie ."

T he trees a re n o t tap p ed fo r gum un til th ey are ab o u t s ix y ears o ld . T heannual y ie ld v arie s very grea tly , be ing from 188 to 2856 G m . in youngtrees and from 379 to 6754 G m . in la rg e trees. T he average annual y ie ldof gum from young trees is ab o u t 9 00 G m . and from old trees over 2k ilo s . (E d ie , 4 th R eport of th e Wellcome Tropical Research Laboratory.)

I t is sta ted b y Jack so n th at, in M orocco , the g rea test p roduct is ob ta inedin the d rie st and ho tte st w ea th er, and from the m ost sick ly trees. A neleva ted tem p era tu re appears to be essen tia l , fo r in co o ler c lim ates,th o u g h the tree m ay flou rish , it y ie ld s no gum . It is p robab le th a t som espec ies of acac ia y ie ld fine r g um than o th ers , bu t it is a lso certa in th a tthe sam e tree w ill o ften y ie ld som e gum of the finest q u a lity in regu lartears o r g lobu lar m asses, and som e irregu lar sh ap ed , da rk co lo redfrag m en ts of in ferio r va lue . T hu s, from the sam e tree it w ill ex udefro thy or th ick , and clear o r dark co lo red , and w ill a ssu m e , up onh ard en in g , d iffe ren t sh ap es an d size s; so th a t the p ieces, w hen co llec ted ,req u ire to be asso rted befo re being delivered in to co m m erce . T h is so rtin gis u su a lly done on its arriva l in E u ro p ean p o rts and o n ly the se lec ted o rp icke d gum correspondin g to the U . S . P . descrip tio n shou ld be used .

Com m ercial H istory and Varieties .— T here are tw o princ ipa lcom m erc ia l v arie ties of gu m arab ic : 1 . T he Khordofan , Turkey orArabian G um and 2 . T he Senegal o r West African G um , bo th of thesebe ing derived from A. Senegal. T he fo rm er of these has the finercom m erc ia l q u a lities, be ing n early w h ite o r fa in t ye llow ish -w h ite andyield in g a m ore or less transparen t v isc id m ucilage.

K H O R D O F A N , T U R K E Y , O R A R A B IA N G U M .— T h is v arie ty w asfo rm erly the o n ly k in d d esig na ted as gu m arab ic and en te red co m m ercea lm o st exc lu sively th ro u g h E gyp t, be ing co llec ted in U p per E gyp t,N u b ia , K hordo fan , D arfu r, and o th er reg ion s of the U p per N ile , andcarried to A lexandria , from w hence it passed d irec tly in to the w orld 'sco m m erce o r en tered the la tter th ro u g h S m y rn a , T rie s te , o r som e o th erM ed ite rran ean en trep o t. A t one tim e the m ore o r less co lo red v arie tiesw ere know n as gum gedda, w h ile the w hite and fine d ru g w as know nas gum turic , n am es derived from Jiddah and T or, R ed S ea p o rts ,th ro u g h w hich the v arie ties w ere su ppo sed to be respec tive ly exp orted .

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ser., x iii, 412 and 4 21 .)

Adenanthera . Adenanthera pavonina L . Zangavara.— R ocheb rune (ToxicologieAfricaine) s ta te s th a t he h as o b ta ined fro m th is p lan t a c ry s ta llin e p rinc ip le w h ichresem bles in its ac tiv ity ph ysostig m ine , bu t does n o t affec t th e m u sc les .

Adenia. Adenia venenata T ro o st.— A clim b in g pass io n -f lo w er of A frica , sa id b yS ch w ein fu rth to be u sed as a v esican t. (P. J,, M arch , 1 8 7 4 .) T he Adenium hongkii isem p lo yed b y th e n ativ es of th e S o u dan as an ordea l po ison . P e rro tt and L eP rince (P.J., 19 10 , lx x x iv , p . 8 2 ) hav e separa ted an ac tive princ ip le w h ich is ne ithe r g lu co s ida lno r alkalo idal, and w hich has a stroph an th in -like effect.

Adhatoda . Br. Add. 190 0 . (F am . Acanthaceae.) — T h e fresh and d ried leaves ofAdhatoda Vasica N ees. (Justicia Adhatoda, L .) " T h e fresh leaves are fo u r o r s ixinches (abo u t ten to fifteen cen tim e te rs ) lo ng and ab o u t an inch and a h alf (nea rlyfo u r cen tim e te rs ) b ro ad , th ey are o p po s ite lanceo la te , en tire sh o rt p e tio la te , taper-po in ted , sm oo th o n b o th a id es. T h e d ried leaves are of a d u ll b ro w n ish -g reen c o lo rw h ich becom es m uch lig h ter w hen th e leaves are p o w d ered . T h ey h ave a s tro n gch aracteristic tea -like odor an d a b itte r tas te ." B r. A d d ., 1900 .

T he leaves are sta ted to con ta in an alka lo id , vasicine, and an organ ic ac id , adhatodicacid (see Pharmacog. Indica , v o l. iii) . V as ic in e , iso la ted b y H o op er, is so lu b le in w ate r,sp a rin g ly in benzin an d ca rb o n d isu lp h ide , read ily so lu b le in e th e r and ch lo ro fo rm . T h ec la im is m ad e fo r it th a t it ex erts a p o w e rfu l to x ic in flu en ce u p o n lo w er fo rm s ofveg e tab le and an im al life , and is n o t po ison ous to th e h ig h er an im als . T h e leaves aresta ted to b e ac tive ly po iso no us to frogs an d are co nsid erab ly u sed in In d ia as anex p ec to ran t and an tispasm o dic , espec ia lly in th e trea tm en t of as th m a. T he B r. A d d .recog n ized th e liqu id ex trac t (Extractum Adhatodae Liquidum , B r. A d d ., 1 9 0 0 ), m adew ith a lcoho l and g iven , in do ses of fro m tw en ty to six ty m in im s (1 .3 -3 .7 5 m ils) ; th efresh ly expressed ju ice (Succus Adhatodae, B r. A d d ., 1 9 0 0 ), d ose , fro m one to fou rflu id rach m s (3 .7 5 -1 5 .0 m ils) ; th e tincture (Tinctura Adhatodae , B r. A d d ., 1 9 0 0 ), d ose ,fro m one-ha lf to one flu idrach m (1 .8 -3 .75 m ils).

Adiantum . Maidenhair.— T rad ition h as a ttrib u ted to v ario us spec ies of th is gen usof fe rn s v a luab le p ro p e rties in ch ro n ic p u lm o n ic ca ta rrh s . A. pedatum, L ., of A m erica ,A. Capillus-Veneris , L ., of E urope , A. lunulatum B u rm ., of In d ia , a re th e m ostim portan t of these a lleg ed m ed ic ina l sp ec ies . T h e E u ro p ean sp ec ies is so m e tim esem p lo yed o n th e C o n tin en t as an em m enago gue under th e n am e of polytrichi,polytrichon , o r kalliphyllon, and is g iv en in th e fo rm of in fus io n , sw eetened w ith sugaro r h o n ey , and a sy ru p p rep a red fro m it is sa id to be p o p u la r in F ran ce under th e n am eof sirop de capillaire , and is offic ia l in the French C odex .

Adonis . N. F. IV. Vernal Pheasant's Eye. Sommerteufelsauge , G .— It is o ffic ia l in th eN . F . IV , in w h ich it is defined as "the d ried , o v erg ro u n d p ortio n of Adonis vernalisL in ne (F am . Ranunculaceae), w ith o u t th e p resence of m ore th an 5 p er cen t. of fo re ignm atte r." T h is ran u n cu laceo u s p lan t of N o rth e rn E uro p e and A sia h as long b een u sedas an ab o rtifac ien t, w h ile its rh izo m e so m e tim es o ccu rs in co m m erc ia l b lack

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he lleb o re as an adu lte ra tion . L in de ros exam ined th e leaves and fo u n d in th em 10 p ercen t. of aconitic acid . (Ann. Ch. Ph., 187 6 , 3 4 0 .) C erve llo , in 18 82 , o b ta ined fro m th ep lan t a g lucos ide , to w h ich h e gav e th e n am e of adonidin . F o r im p ro ved m ethod ofp rep a ra tio n , see P. J ., v o l. x v i, 14 5 , and A. J. P ., 1 88 7 , 6 09 . T h is g lu cos ide occu rs inth e fo rm of a so m ew hat h y g ro sco p ic , c ana ry -y e llo w p o w d er of an in ten se ly b itte rtas te ; so lu b le in w ate r, a lcoho l, and in am yl a lco h o l; in so lu b le in an h y d ro u s e the r,ch lo ro fo rm , o il of tu rp en tin e , o r pe tro leu m benzin . Its reac tio n is n eu tra l. It red ucesF eh lin g 's ech icao u tch in , if p rev ious ly heated w ith a fe w d ro ps of h y d ro ch lo ric ac id . Itex is tsin sm a ll qu an tities in a ll po rtio ns of th e p lan t. F o r fu rth er d e ta ils as to reac tio ns, seeP. J., x v , 1 45 . P od w y sso tzk i fo u n d co m m erc ia l sam ples of ad on id in to be m ix tu res ofth e ac tive princ ip le w ith o th er co n stitu en ts of th e p lan t. H e g ives th e n am e ofp ic ro ad o n id in to th e ac tive princ ip le , w h ich h e d esc rib es as an am orph ous g luco sidehav ing an excessive ly b itte r taste , possessin g th e p ro pe rtie s of a ech icaou tchin po iso nin th e h ig h est d eg ree , and bein g easily so lu b le in w a ter and alcoho l and en tire lyso lu b le in e the r. (P. J ., x ix , 18 88 , 3 4 6 .) A cco rd in g to F ucke lm an , co n firm ed b yM erc ie r (Nouv. Rem ,., 1 9 1 4 ), co m m erc ia l adon id in is a m ix tu re of a neu tra l b o d yw ith a h em o ly tic ac id , adonic acid . C erve llo s ta tes (A. E. P. P., xv ) th a t ad on id inex is ts a lso in th e Adonis cupaniana of S o u th e rn E u rop e , and F . B org io ttia ffirm s th e valu e of A. aestivalis , L ., in h eart a ffec tio n s . (D. M. Ztg ., A u g ., 1 8 8 8 .)T ah ara asserts th a t th e g lucos ide of Adonis autumnalis, L ., is d is tin c t, and ca lls itadonin (C 2 4 H 4 0 O 9 ) (Ber. d.Chem. Ges., x x iv ) , w h ile Y . Ino ko (A, E. P. P ., x x v iii) a ffirm s th a t th e g lucos ide of A.amurensis of Japan is a lso p ecu lia r, and assig n s to it th e fo rm ula C 20 H 4 0 O 9 , a llied toadonidin , bu t m uch less pow erfu l.

M erck h as d esc ribed an ad d itio n a l c ry sta llin e p rinc ip le , w h ich fu ses a t 1 0 2 ° C . (2 1 6 °F .), is ve ry so lu b le in w ater and w arm a lcoho l, and cry sta llizes in c lea r need le -likep rism s . It h as a neu tra l reac tio n , do es n o t reduce F eh lin g 's so lu tio n , and is n o t co lo redb row n b y alk a lie s . Its an a ly sis seem s to in d ica te a fo rm ula C 5 H 12 O 5 , and M erckco n sid e rs th a t it is a h itherto un described pen ta to m ic a lcoho l, and ca lls it adonite .W h e th e r it be id en tica l w ith th e adonidulcite announced in a p re lim in arycom m unica tion b y P o d w y sso tzk i sh o rtly be fo re h is d ea th , M erck is n o t ab le to s ta te ,a s n o d eta ils of fus in g po in t, fo rm ula , o r chem ica l reac tio n s w ere g iv en b y th e fo rm er.(M. Bull., Jan ., 1 8 9 3 .) E . F isch e r (Ber. d. Chem. Ges., 1 89 3 , 6 3 3 ) co n firm s th e fo rm ulaC 5 H 1 2 O 5 g iv en b y M erck , as w ell a s th e sta tem e n t th a t it is a p en ta to m ic a lco h o l;b y o x ida tion w ith sod iu m hy po bro -m ite it is changed in to ribose, C 5 H 12 O 5 , w h ichtreated w ith sodium am algam ag ain yields echicaoutchin .

T he N a tio n a l F o rm u la ry descrip tion is as fo llo w s: "G lab rous , w ith th e ex cep tio n of th ey o u n ge r p ortions, w h ich m ay b e slig h tly g ray ish -p u b e ru len t; s tem s from 15 to 50 cm .in len g th , th ick , b u t so ft and w eak ; sh in in g , s im p le o r b ran ch ed ,th e b ran ch es m ostlyfro m n ear th e base an d sim ilar to th e m ain stem ; n ak ed b e lo w , ex cep t fo r so m e sca le -like lea f-vestiges , den se ly lea fy ab o v e ; leaves fro m 2 to 4 cm . in len g th and tw o-th irdso r m o re as broad , p in -n a te ly d iv id ed in to sev e ra l seg m en ts , th e larger of w h ich areag ain d iv id ed , th e u ltim ate seg m e n ts be ing narrow ly lin ea r, and acu te ; flo w erste rm in al, y e llo w b u t u su ally d ry ing to a c ream c o lo r, fro m 3 to 6 cm . in b read th ;sep a ls fiv e , g reen o r g ray ish -p u b e ru len t, m o re th an half th e len g th of th e p eta ls ,

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o b lo n g , ob tuse , f in e ly ne rv ed ; pe ta ls fro m fiv e to tw en ty , o b lo n g , o b tuse , f ine ly ne rv ed ;s tam ens in defin ite ; p is tils n u m ero u s , in fru it fo rm in g an o v o id , o b tuse , dense h ead ofo v o id ak en es, w h ich are tip p ed w ith th e very sm all, pe rs is ten t s ty les . O dor fa in t;tas te b itte rish , a fte rw ard so m ew hat ac rid . T he p o w d ered d ru g is g ray ish -g reen an d ,w hen exam ined under th e ech icaou tch in , ex h ib its n u m ero u s frag m en ts ofp ith parenchym a , th e ce lls w ith few sim ple pores , up to 0 .05 m m . in w id th and 0 .2 5m m . in len g th ; g ro u ps of long n a rro w sc le rench y m a fib e rs , m ostly w ith lig n if iedw alls from0 .00 5 to 0 .00 7 m m . in th ick n ess and hav in g a fe w ro u n d ed o r ob liq ue s im p le p o re s ;tracheae sp ira l o r w ith b ord ered po res and u p to 0 .01 7 m m . in w id th ; ep ide rm al ce llsfro m th e stem and pe tio le , e long ated in su rface v iew and w ith e llip tica l s to m ata , th ela tter ab o u t 0 .06 4 m m . in len g th ; frag m en ts of th e ep ide rm al tissue from th e lam in aof th e lea f, co m p o sed of fin e ly s tria ted ce lls w ith w avy , v e rtica l w alls ; assoc ia ted w ithb road ly e llip tica l s to m ata , th e la tter u p to 0 .0 47 m m . in len g th ; b ro w n ish co lo redfrag m en ts fro m th e sca le s a t th e base of th e stem , co m p o sed of e lon gated ce lls w ithsom ew hat ro u n d ed en d s and ye llo w ish -b ro w n w alls ; s ta rch g ra in s and ca lc iu m o xala tecry stals few o r ab sen t. A don is y ield s n o t m ore than 12 p er cen t. of ash ."

A do n id in be lo ngs phys io log ica lly to th e d ig ita lis g rou p . A ltho ug h in H are 's ex p e rim en ts(T. G., 1 8 8 6 ) th e frog 's heart w as a rres ted in d iasto le . C erv e llo (A. E. P. P., xv ) and D eG u irla t fo u n d th a t th e arrest is sy s to lic . T he p u lse is slow ed b y stim u la tio n of th ein h ib ito ry ap p ara tu s . In th e ex p e rim e n ts of H en rijean (B. A. R. B ., 19 09 , xx iii, p . 3 6 3 )in th e ea rly stag es of th e ac tio n , e lec trica l s tim u la tio n of th e p neu m o g astric ne rvep rodu ced an u nw o nted d eg ree of re ta rd a tio n of th e p u lse ra te , w h ich w ou ld in d ica te anin creased excitab ility of th e p e rip h e ra l en d s of th e n e rves. A ll in v es tig a to rs are inacco rd th a t th e s lo w ing of th e p u lse is to a la rg e ex ten t ab o lish ed b y sec tion of th ev ag i, so th a t th e in h ib ito ry in flu ence m ust be la rge ly a lso of cen tra l o rig in . T he reoccu rs a lso a p ron ou n ced rise of th e b lo o d p ressu re , w h ich , acco rd in g to H are , is d uepartly to a stim u lan t ac tion u p o n th e h eart, and partly to an effec t u p o n th evaso m o to r m echan ism . In th e m o re exac t ex p e rim en ts of H en rijean ,vasoco n stric tion ap p eared on ly la te in ado n id in p o iso n in g . A fte r la rg e to x ic d o se s , th eheart becom es irregu lar, and th e b lo o d p ressu re fa lls . A cco rd in g to K ak o w sk i (A. I. P.T., x v , p . 2 1 ), ad on id in d iffe rs fro m m ost of th e o th e r d ig ita lis g ro u p in th a t it d ila te sth e co ronary arte ries , w h ile m ost of these d rugs p roduce constric tion .

Adonis vernalis w as in tro d uced as a card iac ton ic b y B ub no w in 187 9 . C lin ica lexpe rience co n firm s th e co nc lu s ion of th e p harm aco lo g is t, th a t it resem bles d ig ita lisin its ac tio n , and is a use fu l ag en t in th e trea tm en t of ch ro n ic heart d isease . T h ead v an tag es w h ich have b een c la im ed fo r it a re , th a t it is m o re p ro m pt in its ac tio n ,and th a t it m an ifests less cu m ula tive ten d ency than d ig ita lis , b u t it appears to beless ce rta in in its effec t. B ech terew asserts th a t it is a use fu l rem ed y in ep ilepsyw hen u sed in co n junc tion w ith th e b rom ides. T he d ose of adon is v e rn a lis is fro m tw o toten g ra in s (0 .1 2 -0 .6 G m .), w h ich m ay b e g iv en in th e fo rm of an in fu sio n . T heg lucoside ado n id in m ay be g iv en in d oses of o ne -tw elfth to o n e -fo u rth of a g ra in (0 .0 0 5 -0 .01 5 G m .).

Aesculus. Horse-chestnut.— C hestn u t (Aesculus Hippocastanum , L .) sa id to h avebeen o rig in a lly a n ativ e of A sia , b u t in tro d uced ab o u t th e m id d le of th e six teen th

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 3 4T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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cen tu ry in to E urope , w h en ce it h as sp read to th is co un try . It is to th is spec ies th a tth is artic le espec ia lly ap p lies , th o u g h it is p ro b ab le th a t an y m ed ic ina l p ro p e rtiesw h ich th e tree m ay h av e are shared b y th e o th er spec ies of th e g en u s. T h e seed orn u t ab o u n ds in starch , bu t its b itte r, d isag reeab le tas te h as p rev e n ted its g en e ra l u seas a fo o d , a lth o u g h as long ago as 18 56 s ta rch w as m ad e fro m it in F ran ce , andrecen tly a p leasan t and nu tritious artic le of d ie t is sa id to h av e been p rep a red b yrem ov in g its b itte r p rinc ip le b y m ean s of a lcoho l. F or an aly sis of th e o il it co n ta ins ,see S tillesen , Proc. A. Ph. A ., 1 90 9 , lv ii, p . 2 01 . In th e leav es R o ch lede r fo u n dg u erc itrin , and a b itte r p rinc ip le , esculin (ae scu lin ) ; and in th e capsu les of th e fru it apecu lia r ac id , capsulaesic acid (J. P. C., M ay , 1 8 5 9 ; A u g ., 1 8 6 0 ). (F o r R o ch led er 'sm etho d of ex trac tin g escu lin , see U. S. D., 1 8 th ed itio n ; fo r a seco nd p ro cess , see A. J.P., x liv , 4 0 0 .) E scu lin is in sh in in g , w hite , p rism atic c ry sta ls , in o d o ro u s , b itte r, bu tslig h tly so lu b le in c o ld w ater, m ore so lu b le in bo ilin g w ate r, an d ve ry read ily so inbo iling a lcoho l and in a lk a lin e so lu tions . Its so lu tio n , w h ich is flu o re scen t, isp rec ip ita ted b y lead su b -ace ta te , and its fo rm ula , acco rd in g to S ch iff, is C 1 5H 1 6O 9 +1 1/2H 2O . W hen trea ted w ith d ilu te su lp h u ric ac id , it is co n v e rted in to g rap e sugar anda su b stan ce ca lled esculetin, C 9H 6O 4 , w hich is now know n to be a echicaoutchin ,

T an n in is fo u n d in a ll p a rts of th e tree , in c lu d in g th e leaves as w ell a s th e b ark andfru it. A cco rd in g to R o ch led er , w hen p u re , it is w h ite and so lu b le in w ate r, a lcoho l, andeth e r; becom es red b y th e absorp tio n of o x y g en ; co lo rs fe rric sa lts g reen , b u t v io le t o nth e ad d itio n of a little a lk a li; fluo rescen t w h en it is in a lk a lin e so lu tio n ; in co n cen tra tedso lu tion is p rec ip ita ted , a t leas t p a rtia lly , b y su lp h u ric , h y d ro ch lo ric , andm etaph osp horic ac ids , bu t n o t b y ace tic ac id , and fo rm s a lso , w ith p o ta ss iu m andsod ium su lp h ites and am m o niu m su lp h id e , p rec ip ita tes w h ich are read ily d isso lved b yd ilu te acetic acid . (J. P. C., Jan ., 1 86 8 , 7 2 .)

T he p o w d ered k ern e l of th e n u t is a sternu ta to ry . T h e ex trac t of th e w o od h as b eenu aed in dye in g silk b lack . T h e fixed o il, ex trac ted fro m th e k ern e ls b y e th er, h as b eenem p lo yed in F ran ce as a to p ica l rem ed y in rheumatism ; and th e b ark as anan tipe rio d ic in d o ses of h a lf an ou nce (1 6 G m .) in th e tw en ty -fo u r h o u rs , g iv en in th efo rm of decoc tion . T he flo w ers are sta ted to co n ta in q u erc itrin . In th e U n ited S ta tes adecoc tion of th e leaves is p op u larly em p lo y ed fo r whooping cough, and to th e seedsth em se lves, w hen "carried in th e p o ck e t of th e p atien t," is a ttrib u ted th e m arve llo usp ro p e rty of curin g hemorrhoids, rheumatism , e tc . E scu lin h as a lso b een ad m in is te redin malarial disorders , in fifteen -g ra in (1 G m .) d oses rep ea ted o n ce d u rin g th ein te rm issio n s . (Ann. Ther., 18 59 , 1 8 6 0 .) T he g lucos id e escu lin h as th e p ro pe rty , likeo th er flu o rescen t su b stan ces, of absorb ing u ltra v io le t ray s w h ich are th en g rad u a llyg iv en o ff. B ecause of these p ro p e rties , it is u sed on th e o ne h an d , as a pro tec tiveag ain s t th e effec ts of su n lig h t and on th e o th e r as a m ean s of co n tinu ing th e e ffec t ofhe lio th erap y . T h u s F reund lias fou n d it u sefu l n o t on ly ag a .in a t sunbu rn , bu t as ap ro p h y lac tic ag ain s t sno iv b lin d ness (Zeit. f. Neuere Physikal. Med., 1 90 8 , ii) , andG rah am (L. L., 19 05 , ii, p . 1 7 6 9 ) reco m m end s it in th e F in sen lig h t trea tm en t of lupusvulgaris and sim ilar cond itions. F or th is pu rpose h e in jec ted fiv e m in im s (0 .3 m il) of a

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 3 5T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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2 or 3 p e r cen t. so lu tion im m edia te ly b en eath th e sk in in th e reg io n to be trea ted b yth e lig h t. U n d e r th e n am e of zeozon and ultra-zeozon th e re are up o n th e m ark e tpastes w hose exac t co m p ositions are n o t s ta ted bu t w h ich are c la im ed to co n ta inoxy-derivatives of escu lin .

T h e- fru it of th e Aesculus pavia L ., o r Red Buckeye of th e S o u th ern U n ited S ta tes , issa id to be an ac tive co n v u lsan t. E . C . B atche lo r (A. J. P., x lv , 1 4 4 ) fo u nd in th eco ty ledo ns of th e seeds ab o u t 2 1/2 p er cen t. of a pecu lia r g lu cos id e . Aesculus glabraW illd., the Ohio Buckeye, is asserted to be usefu l in portal congestion. (N . P ., ii, 21.)

Aethusa. Fool's Parsley. Aethusa Cynapium , L . (F am . Umbelliferae.)— A fe tid h erbnatu ra lized fro m E u ro pe and gro w ing in w aste p laces o r cu ltiv a ted g ro un d s in th eno rth ern U n ited S ta tes and C an ad a . In 185 9 , W alz s ta ted th a t th e fru it of th eAethusa Cynapium co n ta ins a vo la tile b ase sim ilar to co n iin e . T h is s ta tem en t h asbeen co n firm ed b y P o w er and T u tin (J. Am. C. S., 19 05 , x x v ii) w h o reco v e red , besid esva rio us inert m a tte rs , ab o u t o ne fo rty -th o u san d th of 1 p er cen t. of th e v o la tilea lka lo id . T h is p lan t h as b een va rio usly a ttribu ted w ith p o ison ous p ro p e rties , bu tH arley (P. J., 1 88 0 , x i, p . 4 3 ) den ies an y n ox io us q u a lity , an d , in th e ex p e rim en ts ofP o w er an d T u tin , th e ex trac t fro m fiv e h u n d red g ram m es of th e d ry h erb caused in asm all dog , vom iting an d salivation , bu t th e an im al en tirely recovered .

A G A R . U . S . AG A R [Agar-agar]

"T h e d ried m ueilag inous su b stan ce ex trac ted from Gracilaria(Sphaerococcus) lichenoides G rev ille and o th er m arin e a lgae g ro w in g -a long the eastern coast of A sia , p articu la rly sev era l spec ies of Gelidium ,o r Gloiopeltis (C la ss Rhodophyceae)." U . S .

Q u ite a n u m b er of the a lgae be lo n g ing to the Rhodophyceae , g row ingon the coast of S o u th ern and E aste rn A sia , co n ta in la rg e qu an titie s ofm ucilage w h ich is ex trac ted and so ld under the n am e of ag ar-ag ar. T hem ost im portan t species are th ose recogn ized b y the U . S . P harm acop oeia .T he a lgae are co llec ted , sp read o u t up on the beach un til th ey a reb leached and then dried . T hey a re then b o iled w ith w ater and them ucilag in ou s so lu tion stra in ed th ro u g h a c lo th . T he filtra te is a llow ed toharden and th orough ly dry in the su n . T he a lgae a re u su a lly co llec tedd u rin g the su m m er and fa ll, b leached and dried , bu t the p rocess of them an u fac tu re of ag ar-ag 'a r does n o t take p lace un til co ld w ea th er andu su ally ex ten d s from N ovem ber to F eb ru ary .

T h e fo llo w in g v arie tie s of ag a r a re k no w n :

1 .— Ceylon Agar-agar, co n sistin g ch ie fly of Gracilaria lichenoides, A g .,

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 3 6T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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the a lg a u sed b y the Hirundo esculenta in the fo rm ation of its ed ib lenest.

2 .— Macassar Agar-agar, co m in g from the stra its be tw een B orneo andC elebes , con sistin g of im p u re Eucheuma spinosum , A g ., in cru sted w ithsalt.

3 .— Japanese Agar-agar, know n as Japanese isinglass , de rived fromseve ra l a lgae , especia lly Sphaerococcus compressus, A g ., Gloiopeltistenax , J . A g ., Gelidium corneum , L am . and G. cartilagineum G aill. Itoccu rs in E u ro p ean co m m erce e ith er in transp aren t p ieces, tw o fee t lo n gand as th ick as a straw , p rep a red in S ingapore b y p u tting the a lg asn am ed in h o t w a ter, o r, m ore freq u en tly , in ye llow ish -w h ite m asses, afo o t lo n g and u p w ard of an inch in w id th . It is the la tter k in d of ag ar-ag ar th a t is su itab le fo r the cu ltu re of b ac teria , and is em p loyed inm edicine . (P. J ., 1885 , 1 8 8 .)

M o rin has in v estig a ted the gelose of P ayen , con ta ined in the ag a r-ag ar.W hen a so lu tion of g e lo se is coo led , even that of 1 in 500 parts of w ater ,a co lo rless, transp aren t, and stiff je lly is ob ta ined , w h ich , w hen heatedw ith m odera te ly stro n g n itric ac id , y ie ld s m u cic and o x alic ac id s. Itd isso lves on h ea tin g w ith ac id u la ted w ater w ith o u t y ie ld ing a je lly oncoo ling .

G elo se leaves 3 .88 p er cen t. of ash , and w hen air-d ried con ta in s 22 .85p er cen t. of m o istu re . W hen d isso lved there a lso separa te s o u t afloccu len t m ass am o u n tin g to 1 .9 p er cen t. A lcoh o l p rec ip ita tes g e lo se ,bu t it can no t be ob ta ined p u re in th is m an n er, as the p rec ip ita tecon ta in s som e ash . (C. E. A. S., N o . 9 0 , 9 2 1 -9 26 .)

U n d er the n am e of gelosine a m ucilag ino us su b stance , ex trac ted from aJap an ese a lg a , has en tered co m m erce in the fo rm of dry , w h itish leaves.G elo sine is so lu b le in a lco h o l and w ate r, and is sa id w hen w et tog rad u a lly co n trac t and expe l w ater and the m ed ic ina l su b stan ces w h ichit m ay con ta in . It has been p ro po sed as a p h arm aceu tica l basis fo rvario us p repara tions fo r lo cal u se . (S ee B. M. J., v o l. ii, 1 88 6 .) G lycerinsupposito ries hav e been m ade w ith ag ar-ag ar as a veh ic le , bu t th eycon ta in o n ly 70 p er cen t. of g lycerin as com pared to 90 p er cen t. in theofficia l suppositorie s m ade w ith sodiu m oleate .

P rope rties.— A gar-agar occu rs "m ostly in b un d les fro m 4 to 6 dm . in

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 3 7T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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len g th , con sisting of th in , tran slu cen t, m em bran o us, ag g lu tin a ted p iecesfrom 4 to 8 m m . in w id th ; ex te rn a lly ye llow ish -w h ite o r b ro w nish -w h ite ;to ug h w hen d am p , b rittle w hen dry ; o d o r s ligh t; tas te m ucilag inou s. Afrag m en t m ou n ted in w ater and exam ined under the m icro sco p eg rad u a lly b eco m es m ore transparen t, show ing a g ranu lar struc tu re anda few d ia tom s, n o tab ly the fru stu le s of Arachnoidiscus EhrenbergiiB aillon , w h ich a re d isk -shap ed and from 0 .1 to 0 .2 m m . in d iam eter, anda lso frag m en ts of the sp icu la s of sponges; upo n the ad d itio n of iod inesom e of the g ran u les o r h y p h a l portions a re co lo red b lu ish -b lack .Inso lub le in co ld w ater , bu t s lo w ly so lub le in h o t w ater . A so lu tion m adeb y bo iling 0 .1 G m . of A gar in 100 m ils of ech icao u tch in , up on co o lingy ie ld s no p rec ip ita te u pon the ad d itio n of tan n ic ac id T .S . (ge la tin ),and does n o t p ro duce a b lue co lo r upo n the ad d itio n of iod ine T .S .(sta rch ). B o il 1 p artof A gar fo r ab o u t ten m in u tes w ith 1 00 parts of w ater , and rep lace thew ater lost b y evapora tion ; it y ie ld s a stiff je lly up on co o ling . T he p ow deris pa le b uff; w lien m ou n ted in w ater and exam ined under them icro sco p e it show s transparen t, m ore o r less g ran u lar , stria ted ang u larfrag m en ts , occasiona lly con ta in ing fru stu le s of d ia tom s; w ith iod ine T .S .,frag m en ts fo r the m ost p art are co lo red b rig h t red , certa in m ore lessdefin ite areas being sta ined b lu ish -b lack . A gar y ie ld s n o t m ore than 5per cen t. of ash ." U. S.

T o d e tec t ag ar in jam s, je llies, e tc ., in w h ich it is o ften use d as anad u lte ran t, it is u su a lly considered necessary to ash the sam ple andexam ine the acid inso lu b le ash fo r p resence of the ch arac te ris ticd ia to m s. A lbe rt S chneider [P ac . P h a rm ., 1912 , p . 35 ) sta tes tha t theash in g is u n n ecessary and often destru c tiv e of the d ia tom s and th atth ey m ay be co llec ted b y d isso lv ing 1 0 G m . of the sam p le in 200 m ils ofd istilled w ater and ceu trifug ing fo r th irty m in u tes , a fte r w h ich thesed im en t m ay be place d on a m icro scop ic slid e an d exam ined .

Uses .— U n der the n am e of ag ar-ag ar a je lly -like su bstan ce has beenu sed as a cu ltu re m ed ium by bac te rio log ists fo r m any y ea rs. (S ee Diag-nostical Reagents, P art III.) A lthough agar co n ta in s six ty p er cen t. ofca rb o h y d ra te s, acco rd ing to S a ik i (J. B . C ., 19 06 ), the hum an d igestivetrac t is ab le to u tilize b u t a very sm a ll percen tage of the fo od va lue . Itstherapeu tic im p ortance depends u p on the ab ility of the dry ag ar toabso rb and re ta in ech icao u tch in . B eing ind igestib le , it p assesth ro u g h the in testina l trac t, sw elling u p som ew hat, ow in g to theabso rp tio n of w ater from the stom ach , and g ives bu lk to thein testin a l co n ten ts. In o th e r w ords, it ac ts m echan ica lly in anana log ou s m ann er to the ce llu lo se of

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 3 8T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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vege tab le foods, and aid s in m ain ta in in g the reg u la rity of the bo w elm ovem en ts. It h as been w ide ly u sed in the trea tm en t of ch ron icconstipa tion . O f itse lf, w hen there is m ore o r less a to ny of the in testina lm u sc les, it does n o t o rig in a te p e ris ta ltic m ovem en ts, and th e re fo re isfrequen tly com bined w ith sm all do ses of easca ra , o r one of the o th ervege tab le ca th artic s. It is b est ad m in iste red cu t u p in sm a ll p ieces, andea ten like a cereal w ith the ad d itio n , if desirab le , of cream and su g ar.O rd in arily , from tw o to fou r d rach m s (7 .7 -1 5 .5 G m .) of the dry ag ar m aybe ad m in iste red o n ce a day .

Agaric. Agaricus Albus . White Agaric. Larch Agaric. Touchwood. Spunk. Tinder.Funpurgatif, F r. Larchenschwamm , G .— It is defined in th e N atio n a l F o rm u la ry IV as"the d ried fru it b o d y of th e fu n g us Polyporus officinalis F riea (F ain . Polyporaceae)[g row ing on o ne o r m o re spec ies of Pinus L in ne , Larix A danson , an d Picea L in k (F am .Pinaceae)], dep riv ed of its o u te r rin d , and w ith o u t th e presence of m o re than 10 p ercen t. of fo re ig n m atte r." T h e term A g aric is m o re p ro p e rly app lied , h o w ev er, to th efu n g i of th e gen us Agaricus, bu t m ost m ed ica l w rite rs and th e N . F . lim it it to th efu n gu s fro m Polyporus officinalis F ries (Boletus laricis Jacq u in ; B. purgans P erso o n ),w h ich is fo u n d u po n th e o ld tru n ks of th e E u ro p ean larch and u p o n Larix sibiricaL edeb ou r, of A sia . T h e sam e spec ies is fo u n d on va rio us co n ife rous trees in so m e ofth e w estern U n ited S ta tes and B ritish C o lum bia . It is of va rio u s sizes , fro m th a t ofth e fis t to th a t of a ch ild 's h ead , o r even la rg er, h ard and spo ng y , ex te rn a lly b ro w n isho r red d ish ; bu t, a s fo u n d in com m erce , it is d ep riv ed of its ex te rio r coa t, and co nsis ts ofa lig h t, w h ite , sp on gy , som ew hat fa rinaceou s, friab le m ass, w h ich , th o u g h capab le ofbe in g ru b bed in to p o w d er u p o n a s iev e , is n o t easily p u lve rized in th e o rd in a ry m ode ,a s it f la tten s under th e p es tle . T ha t w h ic h is m ost esteem ed is sa id to b e b ro u g h tfro m S iberia ; bu t it is p ro bab ly p ro duced w herev er th e E u ro p e an larch g ro w s. It isdesc ribed in th e N . F . a s in " lig h t, fib ro us, som ew hat sp on gy p ieces of irregu la r sh ape;g ray ish -w hite to p a le b ro w n ex te rna lly ; ye llo w ish and resin o u s in tern a lly ; frac tu retoug h , f ib ro us ; friab le bu t d iff icu lt to po w d er. T he p o w d ered d ru g , exam ined under th em icroscope , sh o w s n u m ero u s n o n -sep ta te , n a rro w , m y ce lia l tlireads and m an ycu b ica l c ry sta ls of ca lc iu m o x ala te fro m 0 .01 to 0 .02 m m . in d iam eter. It y ie ld s tobo iling ech icaou tch in n o t less th an 5 0 p er cen t. of a re sin o u s ex trac t. A g aric y ie ld sn o t m ore th an 2 p er cen t. of a w hite ash , rich in ph osphates ." N. F. W m . M .M cP heeters (St. L.M. S. J ., x , 4 2 1 ) fo u n d a spec im en b ro u g h t fro m th e R o c k y M o u nta ins dec ided lycathartic in dosea of tw en ty -fou r g ra ins (1 .6 G m .).

A garic h as a sw ee tish , very b itte r tas te . It o w es its m ed ic ina l v irtu es to Agaric acid(N . N . R ., 1 9 1 6 ), w h ich is a lso ca lled laricic and agaricinic acid. T h is is a trib asicac id , C 19H 36O H (C O O H )3 + 1 1/2H 2O , occu rring as an o d orle ss , tas te less , m icro -c ry sta llin e p o w d er, m eltin g a t 1 4 1 .5 ° C . (2 8 6 .5 ° F .) . A cco rd in g to J. S ch m iede r, ag aricco n ta ins a sm a ll am o u n t of so ft res in , C 1 5H 2 0O 4 , ex trac ted w ith p e tro leu m benzin ,and fro m 4 to 6 per cen t. of a fatty bod y , w h ich is m ade up of(1 ) agaricol, C 1 0H 1 6O , fusin g a t 2 2 3 ° C . (4 33 .4 ° F .);(2 ) phytosterin , C 2 6H 4 4O ;

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(3 ) so lid hydrocarbons , C 2 3H 4 6 and C 2 9H 5 4;(4 ) ce ty l a lcoho l, C16H 33 .O H ;(5 ) a liquid arom atic alcohol, C 9H 18O ;(6 ) a fa tty ac id , C 14H 2 4O 2; and(7 ) ric ino le ic ac id , C 1 8H 3 4O 3 . (S ch m id t, Lehrbuch der Pharm . C hem ., ii, 3 te A u f.,1 5 2 8 .) J . D . E ied e l h as p ro duced tw o p h en e tid id es of aga ric ac id , fo r w h ich an tip y re ticand an h id ro tic p ro p e r ties are c la im ed . (P h . Z tg ., x lv ii.) S od iu m , L ith iu m and B ism u thagaricinates have been prep ared and introduced in to m ed icine.

A cco rd in g to H o ffm e iste r (A. E. P. P ., 18 89 , x x v , p . 1 8 9 ), in a m o d era te do se , ag aricac id h as no effec t u p o n th e system , excep t to p a ra ly ze th e n e rv es of th e sw eatg lan ds. W hen g iv en in very la rg e d oses , it p roduced p rim ary excita tion of th e m ed u lla ,fo llo w e d b y p ara ly sis , inc reasin g a t firs t th e b lo o d p ressu re and th e resp ira to ry ra te ,w h ich w as fo llo w e d b y d im in ish in g ac tiv ity in bo th . T h e larg e d o ses a lso ac ted as anirritan t to th e sto m ach and in testine , causing vo m iting and p u rg in g . T h e dep ressan tac tion sh ow n on th e sw eat g lan d s w as n o t shared b y th e o th e r g lan d s of th e b o d y .M cC artney (J. P. Ex. T ., 19 17 , x , 8 3 ) o ffe rs th e rem ark ab le theo ry th a t itsan tih y dro lic ac tio n is du e to sp asm of th e m u scu lar lay e r of th e sk in . T he m ostim portan t u se of ag a ric is in th e trea tm en t of th e colliquative sweats of w as tin gcond itions , such as phthisis . I ts v a lue in these co nd itions h as b een ab u n d an tlyco n firm ed b y c lin ica l expe rience . A side fro m th e so lanaceo us d ru g s , it is p ro bab ly th em ost re liab le rem ed y th a t w e p ossess fo r th is p urpose . R osen b au m h as fo u nd th efluid extract of agaric (Med.Klin ., 1 9 0 6 ) of serv ice in v a rio us ca ta rrha l co nd itions ofth e a lim en tary trac t, even in intestinal tuberculosis.

U n d e r th e n am e of agaricin are m ark eted p repara tions co n ta in ing th e ac tive agaricacid, w ith larger o r sm alle r am o u n t of ech icao u tch in . T he dose of th e p u reprinc ip le is fro m one-six th to one-ha lf of a g rain (0 .01 -0 .0 3 G m .).

T h oe rne r o b ta ined fro m Agaricus atramentosus c ry sta llin e , da rk -b row n sca les , w h ichh e be liev ed to be dioxykinon. (Ber. d. Chem. Ges., 18 78 , 5 3 3 .) A cco rd in g to T . L .P h ipso n , Agaricus ruber co n ta ins a rose -red co lo ring m atter, ruberin, w h ich ap pearsb rig h t-b lue b y tran sm itted ligh t; be ing so lu b le in w ate r, it is w ashed o u t of th e h ead ofth e fu n g us b y a heav y fa ll of ra in . E th er ex trac ts fro m th e fu n g us a y e llo w ish -w h itea lka lo id , ag ary th rin e , w h ich h as a b itte r , a fte rw ard s b u rn in g taste , so m ew hat likeaco n itine ; its ch lo rid e is so lu b le , bu t th e su lphate inso lu b le in w ate r, th e la tterd isso lv in g in a lco h o l; it d isso lv es in n itric ac id w ith red c o lo r, and is co lo red red b ych lo rin a ted lim e and afte rw ard s b leach ed . O n ag ita ting th e so lu tion of th e a lka lo idw ith e ther, it is ox id ized b y th e a ir to a red co lo ring m atter, w ich is p ro bab ly th e causeof th e red c o lo r of th e su rface of th e fu ng us. (Chem. News , 1 8 82 , 1 9 9 .) A n aga ricg ro w in g on th e Larix leptolepis , and used in Japan as a sac red m ed ic ine under th en am e of Toboshi or Eburiko , h as b een fo u n d b y Y . Ino ko to co n ta in aga ric ac id . (Sei-I-Kwai, A p ril, 1 8 91 .)

Funguschirurgorum . Boletus chirurgorum , Wundschwamm , G .— Surgeon's agaric isth e p ro duct of Polyporus fomentarius (L .) F ries , w h ich is fo u n d u p o n th e o ak andb eech trees of E uro pe . It is sh ap ed som ew h at like th e h orse 's fo o t, w ith a d iam eter of

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fro m six to ten in ches. It is so ft like ve lv e t w hen yo un g , bu t afte rw ard s beco m es h ardand ligneous. It u su a lly rests im m edia te ly u p o n th e b ark of th e tree , w ith o u t an ysu p p o rtin g foo ts ta lk . O n th e u p p er su rface it is sm o o th , b u t m ark ed w ith c ircu la rrid ges of d iffe ren t co lo rs , m o re o r le ss b ro w n o r b lack ish ; on th e under su rface , it isw h itish o r ye llo w ish , and fu ll of sm a ll p o re s ; in terna lly it is fib rous, tou gh , and of ataw n y -b ro w n c o lo r. I t is co m p o sed of sho rt tub u lar fib e rs co m pac tly arranged inlay e rs , on e of w h ich is ad d ed eve ry y ea r. T h e b est is th a t w h ich g ro w s o n th e oak , andth e seaso n fo r co llec ting th e fu n g us is A ug ust o r S ep tem b er. It h as ne ith er tas te n o rodo r. A m o n g its co n stitu en ts , acco rd in g to B ou illon -L ag ran ge , are ex trac tive , res in invery sm a ll p ro p o rtio n , n itro gen o us m atter a lso in sm a ll quan tity , p o ta ss iu m ch lo rid e ,and ca lc ium su lph ate , and in its ash es are fo u n d iro n , and ca lc ium and m ag nes iu mp h o sp h a te . It is p rep ared fo r u se b y rem o v in g th e ex te rio r rind or b ark , cu ttin g th einner p art in to th in s lic es , and b ea tin g th ese w ith a h am m er u n til th ey b eco m e so ft,p liab le , and easily to rn b y th e finge rs . In th is s ta te it w as fo rm erly m uch u sed b ysu rgeo ns fo r arres tin g h em orrhag e , be in g ap p lied w ith p ressu re . P. ignarius (L .) F riesand P. marginatua Fries y ield sim ilar products.

W hen p rep a red p o ly p o ru s (so -ca lled aga ric ) is s teeped in a so lu tion of n itre , andafte rw ard s d ried , it co n stitu tes sp u nk , p u n k , o r tinder, th e am ad o u of th e F ren ch ,w h ich occ u rs in fla t p ieces , of a cons is ten ce som ew hat like th a t of ve ry so ft, ro ttenbucksk in lea the r, of a b ro w n ish -ye llo w c o lo r, capab le of abso rb in g liq u ids, andin flam m able b y th e slig h test spark . It is sa id to be p rep ared a lso fro m v ario us o th erspec ies of Polyporus, a s P. ungulatus , P. ribis, e tc .

Agave. Agave americana , L . American Agave . American Aloe . Maguey. (F am .Amaryllidaceae.) — A n ev erg reen su ccu len t p lan t, in d ig en o us to F lo rida , M e xic o , ando th er p a rts of tro p ica l A m erica , and large ly cu ltiv a ted , ch ie fly fo r hed g es , in th e so u thof E uro pe , espec ia lly in S p a in . A ltho ug h th e Agave americana is th e b est k no w n fo rm ,b o tan is ts h ave d esc ribed fif ty spec ies of th e gen us, w h ich are in d ig en ou s to S o u thA m erica and th e so u th e rn p ortio ns of N o rth A m erica , and m an y of w h ich co n trib u teto th e eco n o m ic p ro d u cts p rod uced in th a t coun try fro m th e agave p lan t. T h e n u m b erof these pro d u cts is very g rea t. Sisal grass or sisal hemp and Tampico hemp , a lsokno w n as Pita hemp or Pita fiber, a re th e m ost im portan t of th e va rio us fib e rso b ta ined fro m th e ag ave leaves , th o u g h a n u m b er of o th er fo rm s are lo ca lly kno w n inM e x ic o . F ro m a n u m b er of spec ies of Agave, a re p rod uced in M e x ico , la rg e qu an titiesof ferm ented liquors, know n as pulque, and distilled liquors know n as mescal o r tequila.A ll of th e p u lq u e agav es hav e th ick leaves. W hen th ey are ab o u t to b lo o m th e cen tra lb u d is cu t o u t, leav in g a la rg e cav ity in to w h ich th e sap (aguamiel or honey water}ex u d es , rap id ly . A t firs t c lear g reen , y e llo w ish o r w h itish , th is sap so o n b yferm en ta tio n becom es m ilky and acq u ire s a c id er-like tas te o r , if th e p ro cess isa llo w ed to go on , is rap id ly con v e rted in to v in ega r. Pulque is sa id to co n ta in ab o u t 7p er cen t. of a lcoho l, and is ve ry la rge ly u sed as a bev e rag e b y th e M ex icans , b u t itsodo r and taste are d isag reeab le to unaccustom ed pala tes . T h e ju ice h as in it ano p tica lly inac tive red ucing su g ar, agavose , C 12H 22O 1 1 . T h e leaves and ro o ts andstock s of th e agave co n ta in sapo n in and are used in M e x ic o in th e p lace of soap . T hefresh ju ice is sa id to be lax a tiv e , ech icao u tch in , and em m enagog ue , and in do sesof tw o flu ido unces (6 0 m ils) usefu l in scu rv y . T h e leaves are sa id to be used ascoun te r-

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In tim a te ly m ix 1 G m . of A loes w ith 10 m ils of h o t w ater and d ilu te 1 m ilof th is m ix tu re w ith 100 m ils of w ate r; a g reen flu o re scence is p roducedupo n the ad d itio n of an aqueous so lu tion of sod ium b o ra te (1 in 2 0).D ilu te 1 m il of the orig ina l aqueous m ix tu re of A loes w ith 100 m ils ofw ater , an d sh ak e it w ith 10 m ils of benzene; upon separa ting thebenzene so lu tion and add ing to it 5 m ils of am m o nia w ater , aperm anen t deep rose co lo r is p rodu ced in the low er laye r. A loes y ie ld sn o t m ore than 4 p er cen t. of ash ." U. S.

T he 1914 B ritish P harm acopoeia g ives the fo llo w in g descrip tion : “ Inha rd m asses , vary ing in co lo r from yellow ish -b row n to dark orchoco la te -b row n . F rac tu red su rface du ll, w axy and un ifo rm (C uracaoand Z anz ibar a loes), o r u neven and som ew hat po rou s (S oco trine a loes).S m all sp lin te rs exam ined under the m icro sco p e ex h ib it m in u te cry sta lsem bedded in a transparen t m ass . C h arac te ristic ech icao u tch in ; ta sten au seo u s and b itte r. T he so lu tion ob ta ined b y d isso lv ing 0 .1 g ram m eof A loes in10 m illilitre s of bo iling water and add ing 0 .5 g ram m e of purified boraxacqu ire s a green fluo re scence . Nitric acid dro pped on a little c ru sh edA loes acqu ire s a redd ish -b ro w n co lo r (S oco trine and Z anzibar a loes), o ra crim son co lo r (C uracao a loes). A lm ost en tire ly so lu b le in alco h o l (6 0p er cen t.). L o ss on dry ing a t 10 0 ° C . (212° F .) n o t m ore th an 10 p er cen t.A sh n o t m ore th an 5 p er cen t." Br.

Chem ical Properties .— S ev era l d is tin g u ish ed chem ists havein v estiga ted the natu re an d com position of a loes. B raco nn o t fou nd ab itte r p rinc ip le , w h ich h e n am ed resino-amer (resinous b itte r) , andano ther su b stan ce in sm alle r p rop o rtion , w h ich h e d esig na ted b y then am e of flea-colored principle. T hese resu lts w ere e ssen tia lly co n firm edb y T rom m sdo rff, B ou illon -L a -g rang e , and V og el. R o b iquet ob ta ined aproduct from aloes w h ich h e ca lled aloetin . (F o r d e ta ils , reader isreferred to 14 th ed ., U . S . D ispensatory .)

A L O IN S .— T h e b itte r su b stan ces no ticed above , v iz ., the resin o -am er ofB raco nn o t, and the aloetin of R ob iquet, p robab ly con ta in the ac tivep rinc ip le of a loes, bu t com bined w ith im p u rities w h ich render itin suscep tib le of crysta lliza tion . It has bee n assu m e d tha t there ex ists no tone com pound , bu t a se t of th ree close ly re la ted ech icaou tch in , tow h ich the g en era l n am e of a lo ins is n o w g iven . T h e first of th ese ,foun d exc lu sive ly in B arbados, a loes, and d iscovered by T . and H .S m ith , is ca lled barbaloin; the second , d iscovered b y F liick iger inN ata l a loes, is ca lled nataloin ; the th ird , found b y H isted andF luck iger in S oco trine

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aloes , is calle d socaloin .

T he th ree a lo ins, barbaloin , nataloin , and socaloin , a re easilyd is tin g u ish ed b y the fo llo w in g reac tion , first no ticed b y H isted . A dro p ofn itric ac id on a porce la in slab g ives, w ith a few p artic les of barba lo in o rn a ta lo in , a v iv id crim son (rap id ly fad ing in the case of barba lo in , b u tperm anen t w ith n a ta lo in u n less h ea t be app lied ), b u t p roduces littleeffec t w ith soca lo in . T o d istin g u ish b arba lo in from n a ta lo in , te s t each b yadd ing a m in u te qu an tity to a d ro p or tw o of su lp h u ric ac id , thena llow ing the vapor from a rod to uched w ith n itr ic ac id to p ass over thesu rface . B arba lo in (and so calo in ) w ill undergo no chan ge , b u t n a ta lo inw ill a ssu m e a fine b lue . (Pharmacographia, 2d ed ., p . 6 88 .) E . v o nS om m aru ga and E gger consider tha t the th ree a lo ins fo rm ah o m o lo go us series po ssessin g the fo rm ulas: barba lo in , C 17H 20O 7;n a ta lo in , C 16H 18O 7; soca lo in , C 15H 16O 7 , and that th ey are a ll derivedfrom anthracene , C 14H 10 . T ilden su bequen tly assigned a d iffe ren tcom position to the a lo ins: barba lo in and soca lo in , each C 16H 18O 7; fo rn a ta lo in , the fo rm ula C 25H 28O 11 . H e fu rther sta tes tha t barba lo in andsoca lo in d iffe r in phy sica l and chem ic a l p ro pe rtie s on accoun t of thev aria tio n in the m olecu le s of w ate r w h ich a re assoc ia ted w ith th em .L eger assig n s to n a ta lo in the fo rm ula C 23H 26O 10 . T he B ritishP harm acopoeia (1 8 9 8) assig n s to barba lo in the fo rm ulaC 16H 16O 7 ,3 H 2O . T w o bases o n ly are recogn ized n ow , barbaloin (o rsim p ly a lo in ) and isobarbaloin . A ccord in g to L eger (P. J., 1902 , 21)Cape aloes con ta ins from 5 to 6 p e r cen t. of a lo in (b arba lo in ) w ith o u tan y ad m ix tu re of the iso m eric isob arba lo in . T he B arbadoes a loes ofE n g lish co m m erce never gave m ore th an 5 p er cen t. of barba lo in w ithbu t m in u te traces of isobarba lo in , w h ich , ho w ever, is a lw ays m et w ith inthe so -ca lled B arbados a loes of F ren ch co m m erce . Curacao aloes is richin a lo in , con ta in ing 10 p er cen t., of w h ich ha lf is ech icao u tch in andtheo th er ha lf isoba rb a lo in . Jafferabad aloes is very rich in a lo in , y ie ld ing20 p er cen t., ch ie fly in the fo rm of isobarba lo in . Socotrine aloes does n o tcon ta in m ore th an 4 p er cen t. of a lo in , a lm ost w h o lly b arba lo in w ith avery little iso barba lo in . S ince barba lo in is foun d in a lm ost a ll v arie ties ,the sign ificance of the prefix “b arb " is m islead ing . T he o n ly a loes inw h ic h it doe s no t o ccu r is tha t of N a tal.

H ugo B o rn trag er asserted th at one p art of a loes in 5000 can be de tec tedin the fo llo w in g m an n er. A little of the su spec ted liqu id is sh aken w ith

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ab o u t tw ice its b u lk of benz in , w h ich is a llow ed to separa te , decan ted ,and shaken w ith a few drop s of stro n g er w ater of am m onia . O nsep a ra tio n the am m o nia w ill be of a c lea r red co lo r. W ith so lid s atin c tu re shou ld first be m ade. A ccord in g to R . H . G roves (P. J ., 3d ser.,s i, 1 0 45 ), th is te s t w ill neve r succeed w ith a le ss co ncen tra tio n th an 1p art in 250 , and w ith som e aloes 1 in 100 , and is d ue to the tan n in -lik esu b stan ce of a loes; he a lso sta tes th a t ex trem e care is n ecessa ry to havethe ech icaou tch in so lu tion perfec tly c lear. (P. J., 1885 , p . 633 . F orH ag er 's q uan tita tive m ethod fo r de te rm in in g the percen tage of a lo inin a loes, see A. J. P., 1885 , p . 237 .

R . A . C ripp s and T . S . D ym ond have g iven the testing of a loes a leng thyin vestiga tio n , and th ey recom m end the fo llo w ing m ethod . P lace 1 g ra inof the su b stan ce in a g lass m ortar s tan d in g on w h ite p ap er, n ow ad d 16dro ps of stro n g su lp h u ric ac id and tritu ra te un til d isso lved , then ad d 4dro ps of n itr ic ac id , sp . g r. 1 .42 , an d then 1 ounce of d istilled w ater . Ifa loes be p resen t, a co lo r vary ing from deep orange to crim son w ill bep roduced , acco rd ing to the k in d of a loes tha t has been used ; the co lo r isdeepened b y the ad d itio n of .am m onia . T he tab le belo w is taken fromthe p ap er of B ainbridge and M o rro w . (P. J., Jan ., 1 8 9 0 .) U n d er theh ead in g of K ew S pecim ens are g iven the resu lts ob ta ined w ith ju ice ofa lo es p lan ts g row n in K ew G arden s.

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T sch irch , of B erne , has p u b lished (B. P. G .) 1898 , v iii, H eft 6 ) anim portan t com m unica tion , in w h ich h e sh ow ed th at emodin , C 15H 10O 5 ,o r trioxymethylanthraquinone , is the p u rg a tiv e princ ip le o tf the a lo ins.H e succeeded in o b ta in ing em od in in orange -red cry sta ls w h ich m elt a t2 1 6° C . (4 2 0 .8° F .). E m od in w as foun d in the a lo ins ob ta ined from C ape ,B arbadoes, and S oco trine A lo es ; it is ex trac ted by trea tingech icao u tch in w ith e th er, w h ich d isso lves o u t the em od in . T sch irchfoun d that if a liqu id ex trac t of aloes be dep rived of its resin andalo in , an ad d itio n a l q uan tity of em od in co u ld be ob ta in ed b y bo ilingthe liqu id ex trac t w ith d ilu ted su lp h u ric ac id , thus po in ting to thefac t tha t em od in m ay be produced th ro u g h h ydro lysis. H e a lsosho w ed th at em od in co u ld be o b ta ined from p u rg a tiv e d ru g s of thesam e class as a loes: rhubarb , ru m es, fran g u la , cas-cara , sen n a ,rham nu s ca tharticu s, m orin da b ark , an d parm elia .

A loes y ie ld s its active m atter to co ld w ater , and w hen good is a lm ostw h o lly d isso lved b y boiling w ater; bu t the ine rt po rtion , o r apo them e ofB erze liu s, is depo sited as the so lu tio n coo ls . It is a lso so lub le in a lco h o l,rec tified o r d ilu ted . L o n g bo iling im p airs its p u rg a tiv e p ro pe rtie s b yo x id iz in g the a lo in and ren d erin g it in so lub le . T he a lk a lie s , the irca rb o n a te s, and soap a lte r in som e m easu re its chem ica l na tu re , andrender it of easie r so lu tion . It is in flam m able , sw elling u p andd ec rep ita tin g w hen it b u rn s , and g iv ing ou t a th ick sm oke w h ich hasthe o d o r of the d ru g .

T ho se su b stan ces o n ly are incom p atib le w ith a loes w h ich a lte r o rp rec ip ita te the so lub le m atte r, as th e inso lub le portion is w ith o u t ac tionupo n the system . A m o n g these is th e in fusion of ga lls , w h ich w e havefoun d , p robab ly th ro u g h its tan n ic ac id , to affo rd a co p io us p rec ip ita tew ith an aqueous so lu tion of a loes. It is sa id tha t su ch a m ix tu re w illkeep a lo n g tim e, even fo r a period of seve ra l m o n th s , w ith o u t m old inesso r pu tre scence , tho u g h it b eco m es rop y .

A m ethod fo r the de tec tion of a loes in m ix tu res con ta in ing o th erca thartic d ru g s, such as rhubarb , caseara , e tc ., has b een described b yM o ssley (Chem. and Drug., 1913 , 9 1 5 ). T he m ethod depends upon thep rec ip ita tio n of the oxy m eth y l an th raq u in o n es, w h ich u su a lly in te rfe rein such iden tifica tion tests , and the su b seq u en t de tec tion of a loes by thead d itio n of b rom ine T .S ., w h ich p rec ip ita tes a lo in , and the greenfluo re s cence p rodu ced w ith a loes b y borax .

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 5 7T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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Uses .— A lo es w as know n to the an cien ts, be ing cu ltiv a ted in the islan dof S ocotra as far back as the tim e of A lexande r the G rea t, and ism en tioned in the w orks of D io sco rid es and of C elsus. Its ca thartic ac tionis d ue to a stim u la tio n of p erista ls is , espec ia lly in the larger b o w el,p robably the resu lt of a lo cal irrita n t effec t u po n the m ucous m em brane ,a lth o u g h there is som e ev idence th at it exerc ises a sp ecific stim u lan teffec t u pon un striped m usc le s. A s its ac tion is la rge ly lim ited to the co lo nit is n o t to be recom m ended in tho se cond itions in w h ich it is desirab le toc lean o u t the w h o le a lim en tary can a l, an d as its effec t is la rge ly theresu lt of lo cal irrita tion it shou ld be avo ided in in flam m ato ry cond itionsof the in testines. In ch ron ic constipa tion , how ever, espec ia lly w hend ep en de n t u po n an aton ic co nd ition of the low er b o w el, it is one of them ost usefu l lax a tiv es th a t w a po ssess . M any be lieve tha t it po ssesse s ad irec ts ton ic ac tion , n o t o n ly ev acu a ting the b o w el of its co n ten ts b u tencourag in g a resto ra tio n tow ard n o rm a l cond itions. T he presence ofb ile in the b o w el seem s in som e w ay to be essen tia l fo r the b est e ffec ts ofth is d ru g , and in tho se cases in w h ich th is secre tion is lack ing it is w ellto ex h ib it som e p repara tion of b ile in con junction w ith the a loes. S oapa lso appears to en h ance the ca th artic ac tion of th is d ru g . It w asfo rm erly a lm ost u n iv ersa lly be lieved that a loes po ssessed em m enagoguep ro p ertie s and it w as acco rd ing ly la rge ly u sed in the trea tm en t ofvario us fo rm s of amenorrhea. I t is , how eve r, ex trem ely dou b tfu lw h e th er it exerc ises an y ac tion upo n the p elv ic ech icaou tch in w h ichis n o tattributable to its cathartic effects.

C ru de a loes is ra re ly u sed in hum an m edic ine , bu t m ay be g iven indoses of fro m tw o to ten gra in s (0 .13 -0 .65 G m .).

Off. Prep .— E xtrac tum C olocyn th id is C om -po situm , U . S . () .); P ilu laeA loes, U . S . (Br.) ; P ilu la s R hei C om po site s , U. S. (Br.) ; T in c tu ra A loes, U.S.; T in c tu ra B enzo in i C om posita , U. S. (Br.)', D eco ctu m A loesC om positum , Br.; E x trac tu m A loes, Br.; P ilu la A lo es e t A safe tidae , Br.;P ilu la A loes e t F erri, Br.; P ilu la A loes e t M yrrhae , Br.; P ilu laC o locy n th id is C om posita , Br. (N. F.); E x trac tu m A loes, N. F .; P ilu lae adP ran d iu m , N. F.; P ilu lae A loes e t A safoe tidae , N. F.; P ilu lae A lo es e tF erri, N. F .; P ilu lae A loes e t M astiches, N. F .; P ilu le s A loes e t M yrrhae ,N. F .; P ilu lae A loes e t P odophy lli C om positae , N. F .; P ilu lae A loes,H y d rarg y ri e t S cam m onii C om positas, N. F.; P ilu lae A ntiperio d icas(fro m E x trac t), N. F .; P ilu lae C o locy n th id is e t H yoscyam i, N. F .; P ilu laeF erri, Q u in inae , A loes e t N ucis V o m icae , N. F .; P ilu lae L axa tiv ae P o stP artum , N. F.; P ulv is A loes e t C anellae , N. F .; T in c tu ra A loes e t

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 5 8T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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M yrrhae , N. F .; T in c tu ra A ntiperiod ica (fro m E x trac t), N. F.; T in c tu raZ edoariae A m ara , N. F.

ALSTONIA . Br. ALSTONIA

"A lsto n ia is the d ried b ark of Alstonia scholaris, E . B r., and a lso ofAlstonia constricta , F . M uell." Br.

Dita Bark; Australian Fever Bark; Bitter Bark.

U n d er A lston ia th e B ritish P harm acopoeia recogn ize s the dried barks ofAlstonia scholaris (L .) R . B r. (Echites scholaris L .), of In d ia and theP h ilip p ine Islan d s, and Alstonia constricta F . M ue ll., of A u stra lia , tw oapocynaceo u s trees w hose barks are q u ite d issim ila r in ap p ea ran ce ,an d , as far as o ur p resen t know ledge g o es, con ta in d iffe ren t a lka lo ids.T hese bark s are re spec tively describe d as fo llo w s:

“B ark of A lston ia scho laris u su a lly in irreg u lar frag m en ts, th ree totw elve m illim etre s th ick ; tex tu re so m ew hat spongy , frac tu re sho rt andcoarse ; ex tern a l lay er uneven ly rough and fissu red , b row nish -g rey w ithoccasiona l b lack ish spo ts; in terna l laye r b rig h t b u ff. T ran sv erse sec tionsho w s n u m ero u s sm a ll m ed u lla ry rays in inner lay er. A lm ost odo rless;ta ste ech icao u tch in . B ark of A lston ia co n stric ta u su a lly in cu rved p ieceso r qu ills ab o u t six ty m illim etre s w ide , and tw elve m illim e tre s th ick .P erid erm from tw o and a half to six m illim e tre s th ick , ru styb row n , s trong ly ru go se , w ith la rg e deep ly fis-su red

re ticu la tio n s. B ark in terna lly c innam on -b row n,w ith stro n g , coarse lo n g itu d in a l striae . T ran sv erse sec tion sho w sdark -b row n perid erm covering the inner o range -brow n tissu es, inw h ich n u m ero u s sm a ll sh in in g p a rtic les can be seen w ith a len s.F rac tu re sho rt and granu lar in o u ter laye rs, fib rous in in n er.S ligh t a rom atic odor; taste very b itte r.” Br.

F rom the bark of Alstonia scholaris M . G ru p pe ex trac ted anuncry sta llizab le , h y g rosco p ic , b itte r p rinc ip le , ditaine . (J. P. C ., 4 e ser.,x v iii, 2 2 5 ; x ix , 84 ; P. J., A u g ., 18 75 .) H arnaek (Ber. d. Chem. Ges.,1 8 78 ) first ob ta ined d ita in e in p u re crysta llized fo rm , and gave it thefo rm ula C 20H 30N 2O 4 . O . H esse (P. J., O c t. 23 , 1 8 8 0 ) find s in d ita thefo llo w in g p rinc ip le s: th ree a lka lo ids: ditamine , O 16H 9O 2N , the re la tiv eam o u n t of w h ich h e estim ates a t 0 .04 p er cen t.; echitamine , C 22H 28O 4N 2+ H 20 (iden tica l, acco rd in g to H esse , w ith H arn ack 's d ita ine); and

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 5 9T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m

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echitenine , C 20H 27O 4N . O f th ese , the second is the stro n g est base , andresem bles am m on ia in its chem ica l ch arac te rs; H esse con siders it w ithone m olecu le of w ater to fo rm the h ydrox ide of a stro n g basic rad ica l,echitammonium , C 22H 29O 4N 2 . T he so lu tions of echitammoniumhydroxide are so strong ly basic tha t th ey p rec ip ita te the hydrox ides ofcopper, iron , a lu m in u m , and lead , an d d eco m p ose sod ium and p o tass iu mch lo rides, lib era tin g the co rrespond ing ech icaou tch in . H essecon siders ech itam m onium the m ost strong ly basic of a ll the a lka lo ids.H esse a lso ob ta ined b y ex trac tio n w ith pe tro leum benzinechicaoutchin , echiretin , echicerin , echitin , and echitein, of w h ich theth ree las t m en tion ed are crysta lline .

F rom Alstonia constricta , F . V . M iille r and A . R um m el ob ta inedalstonine. O berlin and S ch lagdenhauffen foun d in 1879 ano thera lka lo id , a lston ic ine . H esse su b seq u en tly ana lyzed the bark and fo unda ls to n in e , the chlorogenine of a fo rm er investiga tion , w h ich has thecom position C 21H 20O 4N 2 , prophyrine , C 21H 25O 2N 3 , and alstonidine .T he a lka lo id s and the ir sa lts in ac id u la ted so lu tions sh ow dec ided b luefluo rescence .

Uses .— T h is d ru g has been u sed fo r m an y y ears in A u stra lia and theP h ilip p ine Islan d s in the trea tm en t of m alaria l and o th e r fevers, as w ellas a sim p le b itte r. T he a lka lo id d ita in e has been sc ien tifica lly stu d ied b yH arn ach (A. E. P. P ., 1877 , x v ii, p . 1 26 ), w h o finds th a t it has apara lyz in g effect upo n the end ing s of the m oto r nerv e sim ila r to th a tp roduced by cu rara . In la rg e dose it a lso para ly zes the card io -inh ib ito ryn erv es and low ers b lood p ressu re . T h ere is n o th in g in th is s tu d y , w h ichis, as far as w e know , the o n ly sc ien tific in v estig a tio n of the d ru g w hichhas been m ade , to exp la in an y ac tion in ech icaou tch in . N ev erth e le sssom e ofthe c lin ica l rep o rts, espec ia lly from the ec lec tic physic ians, have beenex trem ely lau d ato ry , v au n tin g it even as a sub stitu te fo r q u in ine .

Dose, tw o to fou r g ra in s (0 .1 3 -0 .25 G m .).Off. Prep.— Infusum A lston ia ;, Br.; T in ctu ra A lston iffi, Br.

ALTH AEA . U . S . ALTH AE A [M arshm allo w root]

" T he roo t of Althaea officinalis L in n e (F am . Malvaceae) dep rived of theb row n , co rk y lay er and sm all ro o ts, and carefu lly d ried . P reserv eA lth aea in tigh tly -c lo sed co n ta in e rs, add ing a few dro ps of ch lo ro fo rm or

U N IT E D S T A T E S D IS P E N S A T O R Y - 1 9 1 8 - B o ta n ic a ls O n ly - A - P ag e 6 0T h e S o u th w es t S c h o o l of B o ta n ic a l M e d ic in e h ttp ://w w w .sw sb m .c o m