The Direction of Thermo Fisher Scientific

Iain Mylchreest Ph.D, VP GM Life Sciences MS

Thermo Scientific Mass Spectrometry Users MeetingIndianapolis

September 22th, 2011

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The World Leader in Serving Science

We are the leading provider of analytical instruments, equipment, reagents and consumables, software and service for research, analysis, discovery and specialty diagnostics

Scale• Nearly $11 billion in revenues

• 37,000 employees in 40 countries

• 350,000 customers in 150 countries

• #227 on Fortune 500

Depth of Capabilities• Innovative technologies

• Applications expertise

• Laboratory productivity partner

Leading Brands

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Enabling Our Customers to Make the World…

Healthier Cleaner Safer

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Markets, Products and Global Presence

Healthcare& Diagnostics

24%

Pharma &Biotech

24%

Academic &Government

26%

Industrial &Applied

26%

Services15%

Instruments,Equipment& Software

33%

Consumables52%

APAC12%

Europe24%

North America60%

ROW4%

Attractive EndMarkets

CompletePortfolio

Global Reach

NOTE: Based on 2010 full year revenues.

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Six Complementary Growth Areas

Analytical Instruments$2.3B

Specialty Diagnostics$1.5B

Biopharma Services$0.7B

Customer Channels$4.5B

Biosciences$0.8B

Laboratory Products$1.9B

NOTE: Revenue amounts for full year 2010 before inter-company eliminations

Provides many opportunities for “connections” projects to enhance customer solutions

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Continuing to Invest in Many Opportunities

New Technologies

Commercial Capabilities

Complementary Acquisitions

Beijing Demo Lab

Ahura Scientific(Portable Raman)

Dionex(Chromatography)

Fermentas, Finnzymes(qPCR)

Solaris qPCRand protein expressionconsumables

thermoscientific.com

GP1 & 3 Centrifuge

with Carbon Fiber Rotors

fishersci.com

Phadia(Allergy/Autoimmunity)

Automated IR and Raman Microscopes

Food Safety Response Center

TREK Diagnostic Systems (Microbiology)

Q Exactive

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World-class analytical technologies and the most complete portfolio of laboratory products and services

In research and analysis• Advanced analytical

instrument technologies• Solutions to improve

laboratory productivity

In healthcare and clinical laboratories• Diagnostic kits, reagents

and consumables • Clinical trial support

and total supply chain management

In manufacturing and the field• Safety-related products

and personal protection• Environmental and

process instruments

Solving the Toughest Analytical Challenges

Laboratory Line Field

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Applications of Mass Spectrometry

Large Organic Molecules

Small Organic Molecules

Trace Inorganic Molecules

Stable Isotope Ratio Analysis

Thermal Ionization Analysis

LIFE SCIENCES EARTH & CLIMATE SCIENCES

LSMS, San Jose and Bremen

LC-MS & GC-MS, San Jose, Bremen, & Austin

ICP-MS & HR-ICP-MS, Bremen

IRMSBremen

TIMSBremen

• Protein structure and sequence

• Biomarker discovery

• PTM analysis• Signal transduction

• Drug discovery & development

• Metabolism • Forensics • Food safety• Clinical• Metabolomics

• Environmental• Food safety• Biomedical• Semiconductor• Energy

• Environmental• Forensics• Geochemistry• Ecology &

metabolic study • Food authenticity

• Geology• Climatology• Geochronology • Nuclear fuel• Nuclear safety

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Increasing App’s in Life Sciences Research and Applied Markets

ExpandingApplication

Base

Metabolite ID/Profiling• Accelerated drug

development and compound assessment

Proteomics• Biomarker discovery• Pathway analysis• Protein identification

BioPharma• Biologics discovery and

development

Metabolomics• Comprehensive study of

metabolites for disease and therapeutic assessment

Environmental• Water, soil analysis

Clinical/Toxicology• Disease markers• Pain management• Drugs of abuse

Food Safety• Inspection, nutrition• Chemical contaminant,

microbial detection

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• Cool Research Tools: - e.g. High performance LC–MSn for protein analysis (Orbitrap Elite)

• Routine Applications: - e.g. High performance LC–MS/MS for small molecule analysis (Q Exactive)

• New Lab Techniques Clinical Research Diagnostics: - e.g. MS/MS in the clinic (clinical chemistry; anatomical pathology; microbiology)

• Portable instruments: - e.g. Point of use portable/personal instruments (XRF; Raman; FTIR; MS?)

Instrumentation Development “Cycle”

Routine Qualitative & Quantitative Applications and Workflows

Cool Research Tools with the Highest Performance

Technology Moving to Portable & Point of Use & Personal

Technology Moving to Diagnostics and Feed Back to the Research Lab

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2000 2003 2005 20081999 2011

DallasProof-of-the-principle for the Orbitrap mass analyzer

DenverExactive benchtopLC-Orbitrap launch

Long BeachResolving power >100,000 demonstratedon concept instrument

Continually Extending MS TechnologyChicagoOrbitrap with external accumulation developedLTQ launch

San AntonioFirst CommercialLTQ Orbitrap launch

PhiladelphiaLTQ Orbitrap Velos

2009

DenverOrbitrap Velos ProOrbitrap EliteQ Exactive

Original 1999 Orbitrap patentUS 5,886,346

ASMS 2011: The biggest launches in Orbitrap history

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• Proteomics• Biomarker Discovery• Metabolism• Metabolomics• Lipididomics• PTM Analysis

• Proteomics• Metabolomics• Bioanalysis• Clinical / Toxicology• Environmental• Food Safety

The Industry’s Leading Portfolio of MS Solutions

Triple Quads

Quantitative Qualitative

Non-targeted Analysis

Targeted Analysis Ion Traps

Hybrid OrbitrapsESI-Orbitraps

High Resolution Accurate Mass

High Resolution Accurate MassFast Scanning

Fast ScanningFast ScanningMS and MSn

ResearchResearchApplied MarketsApplied Markets

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• Metabolite profiling, peptide sequencing, toxicology

• Sensitivity equal to high performance triple quads

• Identify, quantify and confirm in one analysis

Strengthening Our Leading Position in Mass Spectrometry

Diverse Technology Introductions

Extending Ion Trap Leadership: Velos Pro

OT Elite Quantum Leap in Orbitrap Performance

Revolutionary Q ExactiveThe “Quanfirmation” Instrument

June 2011 ASMS Launches

• Metabolite ID, peptide sequencing

• Fastest and most sensitive ion trap on market

• Ideal hybrid front-end• New fragmentation capability

• Proteomics, detailed structural analysis, Top Down

• High field Orbitrap most significant advance since first Orbitrap

• Resolution and scan speed 4X current Orbitrap

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Driving Progress in Integrated Workflows

Sample Preparation

Data Analysis & Interpretation,Distributed informatics

MS Analysis

• Proteomics• Drug Discovery/DMPK• Water Testing• Clinical testing • Food safety• Metabolomics• …………….

Leveraging total company capabilities and expertise

Sample Introduction

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New Software Tools to Support Workflows

New leading edge software for challenging MS workflows

MetQuest 1.0• For HR/AM qual/quan metabolic screening• Unbiased full-scan data reveals unexpected metabolites

Tracefinder 1.1• Automate environmental, food safety & clinical workflows • Supports Triple Quad, Ion Trap and Exactive experiments

Xcalibur 2.1• Core software control for all Thermo Scientific MS systems• Now supports TLX/multiplexing and Turboflow automation

Exactfinder 1.0• Integrated HR/AM qual/quan workflow analysis • Targeted and non targeted screening

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New Proteomics Tools

Proteome Discoverer 1.3• Comprehensive mass informatics platform for data mining• Integrate biological information from multiple sources

Seive 2.0• For label-free, semiquantitative, differential expression• Expanded to support metabolomic & lipodomic workflows

Pinpoint 1.2• Enhances speed and confidence in targeted quantitation.• Supports multiple experimental approaches including HRAM

Thermo Scientific Pierce Enrichment Kits • Enrich, capture and identify proteins, peptides, kinases• Peptide Calibration kits and libraries, ActivX kinase probes

Easy-nLC 1000• Split-free, nano-flow LC optimized for biomolecule separation• Effortless ultra high pressure operation (1000 bar, 15,000 psi)

Leading edge tools for proteomics research

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Novel MS Technologies: Applicatios Growth Drivers

Advances in Hardware, Software and Reagents Move Applications to Higher Throughput

Technology improves – applications growth follows

QuantitativeQualitative Quantitative /Multiplexed

Structural accuracy at high sensitivity results in complete protein sequence determination including PTMs

High sensitivity, accuracy, precision multiple protein quantitation in biological media

High sensitivity, accuracy, precision multiple protein quantitation in biological media –many experiments in one run

Hardware Hardware Hardware

Software SoftwareSoftware

Reagents Reagents Reagents

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Summary

• Dionex acquisition: comprehensive HPLC portfolio complements leading MS technologies

• Velos Pro Ion Trap: leadership extended with high speed quantitative capabilities

• High field Orbitrap Elite: with >240,000 resolution, the most significant advancement since first Orbitrap

• Q Exactive: Revolutionary “Quanfirmation:” screen, identify, confirm and quantify in one run

• Workflow based software: comprehensive new suites for all applications