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Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. Copyright © 2017 the authors This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Articles: Cellular/Molecular The dendrites of CA2 and CA1 pyramidal neurons differentially regulate information flow in the cortico-hippocampal circuit Kalyan V. Srinivas 1,3 , Eric W. Buss 1,5 , Qian Sun 1 , Bina Santoro 1 , Hiroto Takahashi 1 , Daniel A. Nicholson 5 and Steven A. Siegelbaum 1,2,3,4 1 Department of Neuroscience 2 Department of Pharmacology 3 Howard Hughes Medical Institute 4 Kavli Institute for Brain Science Columbia University, 1051 Riverside Drive, New York, NY 10032, USA 5 Department of Neuroscience Rush University Medical Center, Chicago, IL 60612 DOI: 10.1523/JNEUROSCI.2219-16.2017 Received: 12 July 2016 Revised: 27 December 2016 Accepted: 7 February 2017 Published: 17 February 2017 Author contributions: K.V.S., D.A.N., and S.A.S. designed research; K.V.S., E.W.B., Q.S., B.S., and H.T. performed research; K.V.S., E.W.B., Q.S., and B.S. analyzed data; K.V.S., B.S., D.A.N., and S.A.S. wrote the paper. Conflict of Interest: The authors declare no competing financial interests. This work was supported by the Howard Hughes Medical Institute. We thank Yeonsook Shin and Austen Sitko for their help with biocytin stainings and the Neurolucida system. We also thank Anastasia Barnett for the help with immunohistochemistry. Corresponding Authors: Kalyan V. Srinivas ([email protected]) or Steven A. Siegelbaum ([email protected]) Postal Address: Columbia University, 1051 Riverside Drive, New York, NY 10032, USA. Cite as: J. Neurosci ; 10.1523/JNEUROSCI.2219-16.2017 Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formatted version of this article is published.

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Page 1: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj

Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreadingprocess.

Copyright © 2017 the authors

This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.

Research Articles: Cellular/Molecular

The dendrites of CA2 and CA1 pyramidal neurons differentially regulateinformation flow in the cortico-hippocampal circuit

Kalyan V. Srinivas1,3, Eric W. Buss1,5, Qian Sun1, Bina Santoro1, Hiroto Takahashi1, Daniel A. Nicholson5 and

Steven A. Siegelbaum1,2,3,4

1Department of Neuroscience2Department of Pharmacology3Howard Hughes Medical Institute4Kavli Institute for Brain Science Columbia University, 1051 Riverside Drive, New York, NY 10032, USA5Department of Neuroscience Rush University Medical Center, Chicago, IL 60612

DOI: 10.1523/JNEUROSCI.2219-16.2017

Received: 12 July 2016

Revised: 27 December 2016

Accepted: 7 February 2017

Published: 17 February 2017

Author contributions: K.V.S., D.A.N., and S.A.S. designed research; K.V.S., E.W.B., Q.S., B.S., and H.T.performed research; K.V.S., E.W.B., Q.S., and B.S. analyzed data; K.V.S., B.S., D.A.N., and S.A.S. wrote thepaper.

Conflict of Interest: The authors declare no competing financial interests.

This work was supported by the Howard Hughes Medical Institute. We thank Yeonsook Shin and Austen Sitkofor their help with biocytin stainings and the Neurolucida system. We also thank Anastasia Barnett for the helpwith immunohistochemistry.

Corresponding Authors: Kalyan V. Srinivas ([email protected]) or Steven A. Siegelbaum([email protected]) Postal Address: Columbia University, 1051 Riverside Drive, New York, NY 10032,USA.

Cite as: J. Neurosci ; 10.1523/JNEUROSCI.2219-16.2017

Alerts: Sign up at www.jneurosci.org/cgi/alerts to receive customized email alerts when the fully formattedversion of this article is published.

Page 2: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj

5Department of Neuroscience Rush University Medical Center, Chicago, IL 60612

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Ih

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Ih

μ

°

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°

° Ω

μ

Ω

°

μ μ

Page 8: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj
Page 9: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj

N n

Dr Sl Sd

N =nπ Dr + Sl − Dr + Sd

θπ Dr + Sl − Dr + Sl θ Dr + Sd

θ =Dr + SdDr + Sl

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R Ω C μ R Ω

Rm

C

SpineScale =SAshaft + SAspine

SAshaft

=πd + NA

πd

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SA μ SA

μ d

N A

μ

Rinput

Rinput

Ih Gh

Ih

Gh

Gh

Ih Ih

Gh

Page 13: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj

Ih

τ τ

gh =g

+V +

Ih = gh V +

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Io Ko α

z F

R T g

g2

Io = g(V- Vrev) V Vrev

μ

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Amigo2-Cre

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μ μ μ

μ

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μ

Ih

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μ

μ μ

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μ

μ

μ

Page 20: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj

Ih

Ih

Ih

Ih

Ih

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Page 22: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj

Ih

Ih μ

Ih

μ

Ih

Ih

Page 23: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj

Ih

Ih

Ih

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μ μ

μ μ

μ μ

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μ

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μ

Page 27: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj

Ih

Ih

Rm Ri

Cm

RInput

Rm Cm

RInput

Rm Ri

Ih Ih

Page 28: The dendrites of CA2 and CA1 pyramidal neurons ...v srv txhvwlrqxvlqjdpxowlglvflsolqdu\dssurdfkrizkrohfhoovrpdw lfdqgghqgulwlfsdwfkfodps srw uhfruglqjv wzr skrwrq joxwdpdwh xqfdjlqj

Ih

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μ

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Ih

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Ih Ih

Ih

μ

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μ

μ

Ih

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Ih

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Ih

Ih

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Ih

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Ih

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Ih

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Ih

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μ

μ

μ μ

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μ

Ih

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Rinput

μ

Ih

μ

μ

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μ

Ih

Ih

Ih

Rinput

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Ih

Ih

μ μ

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f

f μ f

μ

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