the combiflash® rf 150 preparative performance at a fraction of the cost teledyne isco confidential

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The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

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Page 1: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

The CombiFlash® Rf 150

Preparative Performance at a fraction of the cost

Teledyne Isco Confidential

Page 2: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

CombiFlash Rf 150 Features■ Flow rate up to 100 mL/min

■ Pressures up to 150 psi (10.3 bar)

■ Binary Gradient

■ Two solvent selectivity

■ Uses standard Rf racks

■ Ceramic piston with no check valves for maintenance free operation

■ Low pressure mixing

■ Gradient accuracy typically 2% of full scale

■ Variable UV or UV-Vis detection options

■ Uses PeakTrak® control software

■ November Software release will add Spectral capabilities to Rf 150

Teledyne Isco Confidential

Page 3: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Optimized for Reversed Phase Purifications

■ Reversed phase purifications often operate at pressures between 75 psi and 100 psi

■ Designed to run at maximum flow rate up to 150 psi

■ Available with either a variable UV or UV-Vis detector

■ Driven by PeakTrak®

Teledyne Isco Confidential

Page 4: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Market Focus for Rf 150

■ Aimed at Academic Market

■ Heavy discounting is needed to win business

■ May not use RediSep® Rf columns

■ Infrequent usage accounts

■ Financially underfunded accounts

Teledyne Isco Confidential

Page 5: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Rf 150 Product Promotions

■ Direct Mail Piece to Academic accounts

■ ACS Members who are Post Doctorial Fellows (5,000)

■ Email blast to University names from R&D List

■ Email blast to University names in Tisco List

Teledyne Isco Confidential

Page 6: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Teledyne Isco Confidential

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Direct Mailer

Page 7: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Teledyne Isco Confidential

Rf 200 versus Rf 150

Rf 200■ RFID rack identification

■ RFID rack detection

■ RFID column detection

■ Supports column plan

■ External detector port

■ Solvent level sensing

■ Injection valve

■ Air purge

■ Four solvents to select from

■ Higher pressure and flow rate limits

Rf 150■ No rack identification

■ No rack detection

■ No external detector

■ DOES NOT SUPPORT COLUMN PLAN

■ No air purge

■ Two solvents to choose from

■ Lower pressure and flow rate

■ No level sensing

■ No injection valve

Page 8: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Competition Biotage Isolera Prime  CombiFlash Rf 150 Isolera PrimePumping System Ceramic no-check valve pump Constant Volume Electric PumpFlow Range 10 - 100 mL/min 5 - 100 mL/minPressure Limit 150 psi (10.3 bar) 145 psi (10 bar)

DetectionVariable UV 200 - 360 nm standardVariable UV-Vis 200 - 780 nm option

Fxed UV 254nm standardVariable UV 200 -0400 nm option

Number of Solvents Two, binary gradient Two, binary gradientProgrammable Gradients Linear, step, isocratic Linear, step, isocraticGradient Accuracy Typically <2% Not Stated Sample Injection Direct DirectUser Interface 10.5" touchscreen 10.4" touchscreenSoftware PeakTrak ProprietaryFraction Collector Internal InternalDimensions 24" H x 14.1" W x 17" D 23.5" H x 14" W x 19.6" DColumn Sizes 4 to 330 Gram Not Stated  Weight   66 lbs.Certifications CE CE, cTUVus

Biotage US List Price of $17,500

Teledyne Isco Confidential

Page 9: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Competition - Agela Cheetah

Agela US List Price Unknown – Sold through VWR

  CombiFlash Rf 150 Agela Cheetah MP 100Pumping System Valveless ceramic metering pump Valveless ceramic metering pumpFlow Range 10 - 100 mL/min 1 - 100 mL/minPressure Limit 150 psi (10.3 bar) 100 psi

DetectionVariable UV 200 - 360 nm standardVariable UV-Vis 200 - 780 nm option

Variable UV 200 - 400 nm standardVariable UV-Vis 200 - 800 nm option

Number of Solvents Two, binary gradientTwo, binary gradient standard

Quaternary gradient option

Programmable Gradients Linear, step, isocratic Linear, step, isocraticGradient Accuracy Typically <2%  Not Stated

Sample InjectionDirect

DirectInjection valve option

User Interface 10.5" touchscreen 12.1" touchscreenSoftware PeakTrak ProprietaryFraction Collector Internal InternalDimensions 24" H x 14.1" W x 17" D   Not StatedColumn Sizes 4 to 330 Gram   Not StatedWeight     Not StatedCertifications CE   Not Stated

Teledyne Isco Confidential

Page 10: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Competition – Lisure Science   CombiFlash Rf 150 Lisure Science EZ PuriferPumping System Valveless ceramic metering pump Valveless ceramic metering pumpFlow Range 10 - 100 mL/min 1 - 100 mL/minPressure Limit 150 psi (10.3 bar) 100 psi (7 bar)

DetectionVariable UV 200 - 360 nm standardVariable UV-Vis 200 - 780 nm option

Variable UV-Vis 200 - 800 nm

Number of Solvents Two, binary gradient Two, binary gradient

Programmable Gradients Linear, step, isocratic Linear, step, isocraticGradient Accuracy Typically <2% +/-3% linear gradient

Sample Injection Direct Direct

User Interface 10.5" touchscreen PCSoftware PeakTrak WindowsFraction Collector Internal InternalDimensions 24" H x 14.1" W x 17" D Not StatedColumn Sizes 4 to 330 Gram Not StatedWeight   Not StatedCertifications CE  Not Stated 

Lisure does not sell outside of India and China

Teledyne Isco Confidential

Page 11: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Competition - Yamazen  CombiFlash Rf 150 Yamazen AI-580SPumping System Valveless ceramic metering pump Not Stated Flow Range 10 - 100 mL/min 0 - 80 mL/minPressure Limit 150 psi (10.3 bar) 145 psi

DetectionVariable UV 200 - 360 nm standardVariable UV-Vis 200 - 780 nm option

Fixed UV 254 nm standardVariable UV 190 - 380 nm

Variable UV-Vis 190 - 600 nm option

Number of Solvents Two, binary gradient Two, binary gradient

Programmable Gradients Linear, step, isocratic Linear, step, isocraticGradient Accuracy Typically <2% Not Stated Sample Injection Direct Not Stated User Interface 10.5" touchscreen Touch screen PCSoftware PeakTrak WindowsFraction Collector Internal InternalDimensions 24" H x 14.1" W x 17" D 30.7" H x 19.7" W x 17.7" DColumn Sizes 4 to 330 Gram Not Stated Weight   Not Stated Certifications CE JIS, CE

Yamazen US List Price $21,200

Teledyne Isco Confidential

Page 12: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Pricing

68-5230-014 UV $24,004

68-5230-015 UV-Vis $25,004

Teledyne Isco Confidential

Page 13: The CombiFlash® Rf 150 Preparative Performance at a fraction of the cost Teledyne Isco Confidential

Teledyne Isco Confidential

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Key Markets

PharmaceuticalDrug Discovery Natural

Products

AgriculturalChemistry Foods

and Flavors

Petrochemicals