the catalyst · 2019-05-13 · one letter, of no more than 400 words, must be from the teacher’s...
TRANSCRIPT
A D V A N C E N O T I C E
JANUARY MEETING Thursday, January 17, 2019
Joint Meeting of the Philadelphia Section ACS, ChemPharma and AlChe Delaware Valley Section
Speaker: JP Northrop
Financial Advisor for Edward Jones Investments
Workhorse Brewing Company 250 King Manor Drive
King of Prussia, PA 19406
See the JANUARY issue of the Catalyst for details,
call the Section Office at (215) 382-1589 or email [email protected].
the Catalyst
Official publication of the Philadelphia Section, ACS
http://philadelphia.sites.acs.org
November Meeting Ullyot Public Affairs Lecture
Dr. Jennifer A. Doudna University of California, Berkeley
CRISPR Biology and Biotechnology: The Future of Genome Editing
November 2018
Volume 103, No. 9
HIGHLIGHTS
Comments From
the Chair 157
News Atoms 158
Speaker’s Abstract
and Biography 160
Teaching Excellence Call
for Nominations 161-162
Career Services
ChemLuminary Award162
Calendar of
Activities 167
November 2018 Page 156
Published monthly except July, August and December by the Philadelphia Section of the American
Chemical Society. All views expressed are those of the editors and contributors and do not necessari-
ly represent the official position of the Philadelphia Section of the American Chemical Society. Edi-
torial matters should be sent to the attention of the Editor-in-Chief c/o the Philadelphia Section ACS,
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA
19104-6323 or [email protected].
Advertising: Vince Gale, MBO Services, P.O. Box 1150, Marshfield, MA 02050,
email: [email protected].
STAFF
EDITOR-IN-CHIEF Robin S. Davis
EDITORS
News Atoms: Alan Warren Proof Editors: Anthony Addison Georgia Arbuckle-Keil Kendra Luther Corrie Kuniyoshi Marge Matthews Alan Warren
ADVERTISING MANAGER
Vince Gale
COMMUNICATIONS COMMITTEE Chair: Liliana Suárez Anthony W. Addison Georgia Arbuckle-Keil Matthew Bodek Robin S. Davis Vince Gale Alan Heldon Corrie Kuniyoshi Kendra Luther Marge Matthews Victor Tortorelli Alan Warren
CONTENTS January Advance Notice ........................................... 155
Comments From The Chair ...................................... 157
Board of Directors Teleconference Meeting ............. 157
News Atoms ............................................................. 158
2018 Philadelphia Section Election Information ........ 158
November Meeting ................................................... 159
Speaker’s Abstract and Biography ........................... 160
Nominations for Pre-College Teaching ..................... 161
Nominations for Undergraduate Teaching ................ 162
Career Services ChemLuminary Award .................... 162
Herb Bassow Chemistry Demonstrations ................. 163
Chemical Consultants Network Meeting ................... 165
Directory of Services ................................................ 166
2018 Calendar of Activities ....................................... 167
the Catalyst
ACS Philadelphia Section
Founded April 15, 1899
Proof Editors: Georgia Arbuckle-Keil Kendra Luther Marge Matthews Alan Warren
ADVERTISING MANAGER Vince Gale
COMMUNICATIONS COMMITTEE Chair: Marge Matthews Anthony W. Addison Georgia Arbuckle-Keil Robin S. Davis Vince Gale Robert Gates Corrie Kuniyoshi Kendra Luther Judy Summers-Gates Victor Tortorelli Alan Warren
November 2018 Page 157
the Catalyst
Lizzy Wagoner
Thank you to all of our Philadelphia Section ACS members for elect-
ing me as your 2018 Chair and staying engaged in our scientific
community. As I write my last column as your Chair, I am honored to
have been a part of such an active and passionate section. Our year
was filled with a wide variety of events and programs, none of which
would have been possible without the talented committee members
and you, the participants. Christie McInnis lead our Younger Chem-
ists Committee to engage our 35 and younger scientists with the Student Poster Session, partner
events, Programs in a Box, and more. Joseph Martino chaired our ChemLuminary Award win-
ning Career Services Committee with many expert panel discussions, educational events, and
networking opportunities. The Women Chemists Committee, under the direction of Kathy
Shaginaw, had another successful PAGES™ event to inspire 6th-grade girls to pursue STEM.
Bill Smith supported the Education & Outreach Committee and organized many events, includ-
ing the Chemistry Olympiad. Our Communications Committee, led by Liliana Suarez has been
working hard this year to update our website and media platform. All of our committee mem-
bers, Board of Directors, and Councilors have been crucial to the successes of our local section
and I know they will continue to improve and inspire the Philadelphia ACS for many years to
come. If you have any ideas or comments, or want to be more involved with the Section please
reach out to [email protected].
This month we celebrate the 29th annual Ullyot Public Affairs Lecture at the Science History
Institute in Philadelphia on November 16, 2018. Dr. Jennifer A. Doudna’s lecture will focus on
her CRISPR-Cas9 work, which provides a simple way of editing the DNA of any organism. For
more information please visit:
https://www.sciencehistory.org/event/ullyot-public-affairs-lecture-jennifer-a-doudna-crispr-
biology-and-biotechnology-the-future-of. This event is definitely not one to miss and I hope to
see you there!
Thank you again for all of your support and I wish you all the best for 2019. Next year will be
even better with even more exciting events!
Philadelphia Section of the American Chemical Society
Board of Directors Teleconference Meeting
Tuesday, November 15, 2018
5:00 – 7:00 PM
GoToMeeting: https://global.gotomeeting.com/join/187081973
Comments
From
the
Chair
November 2018 Page 158
the Catalyst
NEWS ATOMS—Alan Warren
Derrick C. Wood of Conestoga High School will receive the 2019 ACS James Bryant Conant
award in high school chemistry teaching, sponsored by the Journal of Chemical Education.
DEATHS
George T. Furst, research scientist, January 8, 2018. He was associate director of technical fa-
cilities and director of the NMR facility in Penn’s Chemistry department.
David Lloyd Douglass, research chemist, April 18th at 66. He was employed by DuPont for 31
years, retiring as global technology manager.
William H. Helfand, pharmaceutical chemist, October 2nd at 92. He was employed for 33 years
at Merck where he served as president of the French division 1970-1974. He retired in 1987 as a
senior vice president in the international division. He donated his significant collection of
ephemera related to medical quackery to the Philadelphia Art Museum.
ACS Philadelphia Local Section
2018 Election Information
The 2018 Philadelphia Local Section electronic ballot was sent out on Tuesday, October 23,
2018 using SurveyMonkey. If you did not receive the notification you may have opted out of
SurveyMonkey or the email may have landed in your “Spam” or “Junk” folder.
In order to vote you can do either one of the two options listed below:
• You can reinstate yourself with SurveyMonkey at
https://www.surveymonkey.com/optin.aspx and after this is done notify Dr. Jason Cross
at [email protected] and he will send you an electronic ballot
• If you wish to vote using a paper ballot you can request one from Dr. Jason Cross by
email [email protected] or phone (215) 895-2641 or mail:
Dr. Jason Cross
Assistant Professor
Drexel University
Department of Chemistry
Stratton Hall 410
32 S. 32nd Street
Philadelphia, PA 19104
All ballots, paper and electronic, must be received by Tuesday, November 6, 2018 at 11:59 PM.
November 2018 Page 159
the Catalyst
NOVEMBER MEETING
Ullyot Public Affairs Lecture
Friday, November 16th
6:00 – 8:00 PM
Dr. Jennifer A. Doudna
University of California, Berkeley; Howard Hughes Medical Institute
CRISPR Biology and Biotechnology: The Future of Genome Editing
Science History Institute
315 Chestnut Street Philadelphia, PA 19106
Lecture 6:00 PM
Reception 7:00 PM
The Lecture and Reception are Free
More Information at https://www.sciencehistory.org/event/ullyot-public-affairs-lecture-jennifer-doudna
November 2018 Page 160
the Catalyst
SPEAKER’S ABSTRACT AND BIOGRAPHY
Dr. Jennifer A. Doudna University of California, Berkeley; Howard Hughes Medical Center
CRISPR Biology and Biotechnology: The Future of Genome Editing
Abstract: Fundamental research to understand how bacteria fight viral infections uncovered
programmable proteins that detect and cut specific DNA sequences. In collaboration with Em-
manuelle Charpentier’s laboratory, we determined how the enzyme Cas9, which is part of
CRISPR-Cas adaptive bacterial immunity, can be harnessed as a powerful technology to alter
genomic sequences in cells. This created a simple, precise and widely adaptable technology for
genome editing – changing or regulating the genetic material – in any cell or organism. Current
research is exploring the diversity of CRISPR-Cas systems in microbes and developing ge-
nome editing for biomedical and agricultural applications. I will also discuss the ethical and so-
cietal implications of genome editing.
Biography: As an internationally renowned professor of chemistry and molecular and cell bi-
ology at the University of California, Berkeley, Jennifer Doudna and her colleagues rocked the
research world in 2012 by describing a simple way of editing the DNA of any organism using
an RNA-guided protein found in bacteria. This technology, called CRISPR-Cas9, has opened
the floodgates of possibility for human and nonhuman applications of gene editing, including
assisting researchers in the fight against HIV, sickle-cell disease, and muscular dystrophy.
Doudna is an investigator with the Howard Hughes Medical Institute and a member of
the National Academy of Sciences, the National Academy of Medicine, the National Academy
of Inventors, and the American Academy of Arts and Sciences. She is also a foreign member of
the Royal Society and has received many other honors, including the Breakthrough Prize in Life
Sciences, the Heineken Prize for Biochemistry and Biophysics, the BBVA Foundation Frontiers
of Knowledge Award in Biomedicine, and the Japan Prize. She is the coauthor with Sam Stern-
berg of A Crack in Creation, a personal account of her research and the societal and ethical im-
plications of gene editing.
Doudna earned a BA in biochemistry from Pomona College and a PhD in biological chemistry
and molecular pharmacology from Harvard Medical School.
November 2018 Page 161
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CALL FOR NOMINATIONS
The Philadelphia Section, American Chemical Society
AWARDS FOR EXCELLENCE IN PRE-COLLEGE TEACHING
The Philadelphia Section of the American Chemical Society will honor two outstanding science
teachers with its Awards for Excellence in Pre-College Science Teaching. One award will be
given to a full-time educator involved in teaching science in grades K-8. The second award will
be given to a full-time educator at the secondary level (grades 9-12) who teaches chemistry.
Nominees must teach in the Philadelphia Section’s geographic area (Philadelphia, Montgomery,
Delaware, Chester, Bucks, Burlington and Camden counties).
Nominations for 2019 will be accepted until February 22, 2019.
Award for Excellence in Pre-College Teaching Nomination Packet Requirements
• A Nominator Recommendation of not more than 750 words submitted by the nominator
according to the guidelines outlined on the Recommendation Form.
• A current curriculum vitae or resume that includes a list of the nominee’s honors, pro-
fessional activities, and additional evidence of service to the profession. This must be
limited to no more than two pages and the activities listed must have occurred within the
past five years.
• A statement by the nominees of not more than 500 words that describes the nominee’s
teaching philosophy or commitment to the profession.
• At least one, but not more than three, letters of support. One letter, of no more than
400 words, must be from the teacher’s current principal or supervisor. Additional letters
of support, of no more than 400 words, may be sent by colleagues, members of the Amer-
ican Chemical Society who are familiar with the nominee’s achievements, or former stu-
dents and parents of former students.
The total nomination package should not exceed 30 pages. The nomination package may be
emailed to [email protected].
For more information, please contact the Philadelphia Section, ACS office: phone: (215) 382-
1589 or email: [email protected].
The award recipient will be honored at our May 2019 Section meeting with a plaque and
honorarium.
November 2018 Page 162
the Catalyst
CALL FOR NOMINATIONS
Philadelphia Section, American Chemical Society
AWARD FOR EXCELLENCE IN UNDERGRADUATE TEACHING IN THE
CHEMICAL SCIENCES
The Philadelphia Section of the American Chemical Society will honor an outstanding undergraduate teacher
with its Award for Excellence in Undergraduate Teaching in Chemical Sciences. The award will be given to a
full-time educator involved in teaching an undergraduate course in the chemical sciences (chemistry,
biochemistry). Nominees must teach in an institution that is within the Philadelphia Section’s geographic area
(Philadelphia, Montgomery, Delaware, Chester, Bucks, Burlington and Camden counties).
Nominations for 2019 will be accepted until February 22, 2019. The nomination should consist of a letter of
nomination, the nominee’s resume and two letters of recommendation. Other supporting information, such as
students’ comments, is welcome. The total nomination package should not exceed 30 pages. The nomination
package may be emailed to [email protected].
For more information, please contact the Philadelphia Section, ACS office: phone: (215) 382-1589 or email:
The award recipient will be honored at our May 2019 Section meeting with a plaque and honorarium.
ACS Philadelphia Career Services ChemLuminary Award
At the 2018 ACS Fall National Meeting in Boston, MA, the ACS Philadelphia and Princeton
sections received the 2018 ChemLuminary Award For Outstanding Local Section Career Pro-
gram Award, which was awarded by the ACS Council of Economic and Professional Af-
fairs. The Sections were honored for a Career Panel Discussion on Non-Traditional Careers
which took place on May 11, 2017 at Bowen Hall in Princeton University and was moderated
by ACS Career Consultant Joe Martino. Panelists included JP Northrop (Edward Jones Invest-
ments), Allen Jones (Students 2 Science), Mukund Chorghade (THINQ Pharma), Molly Hoke
(Mallinckrodt Pharmaceuticals) and Kevin Cannon (Penn State Abington). Remarks were also
given by Deborah Cook and George Theodoridis, the respective 2017 Chairs of the ACS Phila-
delphia and Princeton sections. Discussions focused on how laboratory chemists transitioned to
careers that are either outside of the laboratory and support the chemical and pharmaceutical en-
terprises or are otherwise completely outside of chemistry. Opportunities for one-on-one net-
working with the panelists along with a formal Q&A session were provided. Approximately 30
participants attended this well-received event, which was sponsored by both the ACS Philadel-
phia and Princeton sections and by an ACS Corporation Associates Local Section Grant.
November 2018 Page 163
the Catalyst
The Philadelphia Section of the American Chemical Society
Presents
The Herb Bassow Memorial
CHEMISTRY DEMONSTRATIONS
FOR
CHILDREN OF ALL AGES
“Genie in the Bottle,” the “Circle of Fire,” “Rainbow glasses,” “Bottle Rocket,” “Liquid Nitrogen
Icecream,” “Instant Hot Lather,” “Balloon-on-a-Stick,” “Incredible Shrinking Balloons,” the
“Chromatography T-shirts,” and much, much more… at
Beury Hall
Temple University
1901 N 13th St.
Philadelphia, PA
Wednesday, December 12, 2018
9:30 AM to 2:00 PM
Coordinators: Dr. Jaskiran Kaur at [email protected] or (215) 204-7161
Dr. Daniele Ramella at [email protected] or (215) 204-1931
Cost: Free and open to the public
RSVP: Please respond by November 28, 2018 and provide the number of students
expected to attend. You can RSVP by sending an email to the coordinators.
Everyone Welcome!
Information concerning the Philadelphia Section activities can be found on the Philadelphia Section Web
Page: http://philadelphia.sites.acs.org/
November 2018 Page 164
the Catalyst
November 2018 Page 165
the Catalyst
CHEMICAL CONSULTANTS NETWORK
NOVEMBER 14, 2018 MEETING
CRISPR AND GENE EDITING PATENTS: WORTH THE FIGHT?
Dr. Meg Baker – Patent Agent
DATE & TIME: Wednesday, November 14th at McKenzie Brew House, Glen Mills, PA
Networking & Appetizers, 5:30 PM; Talk and Business Session, 7:30 PM
Click here to register
Abstract: In May of 2012, Doudna and Charpentier published an article suggesting that a
bacteria defense system known as CRISPR-Cas9 could be re-engineered (molecularly) to
make it useful for targeted gene editing due to its inherent sequence specific guide RNA
segment. In December of 2012, Feng Zhang filed a patent on how to make edits in human
cells using such a system. Who invented human gene editing using a pair of molecular scis-
sors made of protein guided by a short piece of nucleic acid that seeks the precise patch of
DNA to cut? And, what is it really worth in research dollars, cost of therapy, or drug sales, to
human well-being and perhaps to the future evolutionary changes to life on earth?
Biography: Meg Baker has been a patent agent since 2000 and has provided IP and com-
petitive technical analysis support to start-ups and other multinationals. She was an accom-
plished research scientist and has extensive experience related to biopharmaceuticals and
novel targets for therapeutic development. She now works independently with individual in-
ventors, start-ups, and small businesses; providing guidance and strategic management for
creation, protection, and licensing of their intellectual property. Meg has an A.B. in biochemis-
try from UC Berkeley, an M.S. from Columbia University, and a Ph.D. from UC Davis in nutri-
tion and pharmacology. Oncology is a major interest, as both her post-doctoral research at
Stanford University and work as an assistant professor at the University of Pennsylvania were
in radiation damage and repair. After leaving the academic world, she was involved with
chemotherapy development and delivery as an oncology group leader in two start-up biotech
companies.
Location: McKenzie Brew House, 451 Wilmington West Chester Pike, Glen Mills, PA 19343.
DIRECTIONS: Use “Directions” button on MAP link
Reservation: Click here to register to attend the event, or e-mail [email protected] or call the
CCN phone number at (267) 666-0949 and leave a message. Fee, including appetizers (dinner and beverages
are not included), is $15 by reservation/cancellation deadline: Saturday, Nov. 10th.
November 2018 Page 166
DIRECTORY OF SERVICES
ADVERTISING INDEX
ACS 166
Micron Inc. 166
Pittcon 164
Robertson Microlit Labs 166
Tyger Scientific, Inc. 166
Advertising: Vince Gale, MBO Ser-vices, P.O. Box 1150, Marshfield, MA 02050; phone: (781) 837-0424
email: [email protected]
Advertising: Vince Gale, MBO Ser-vices, P.O. Box 1150, Marshfield, MA 02050; phone: (781) 837-0424
email: [email protected]
November 2018 Page 167
the Catalyst
PHILADELPHIA SECTION, ACS
CURRENT CALENDAR OF ACTIVITIES
Spring 2019 National Meeting in Orlando https://www.acs.org/content/acs/en/meetings/national-meeting/abstract-submission.html?sc=home_4up_OR19_od
Date and Time Event Location/Information Tuesday, November 6
6:00 PM – 8:30 PM
The Chromatography Forum of the Dela-
ware Valley Monthly Meeting: 2D-LC by
Peilin Yang & Douglas D. Richardson
Holiday Inn Lansdale-Kulpsville
1750 Sumneytown Pike
Kulpsville, PA 19443
See:
http://www.cfdv.org/meetings/Special++Two+Speaker+Event+on++
2D-LC
Thursday, November 8
11:30 AM – 2:30 PM
Joseph Priestley Society Symposium:
The Commercialization of Green Chemi-
cals and Processes and Their Increasing
Role in Consumer and Industrial Markets
Science History Institute
315 Chestnut Street
Philadelphia, PA 19106
See webpage for details https://www.sciencehistory.org/event/joseph-priestley-society-
201811
Monday, November 12
6:00 PM Social Hour
7:00 PM Talk
Delaware Valley Mass Spectrometry Dis-
cussion Group: Identifying Sex Differ-
ences in Colon Cancer Metabolism by
Caroline Johnson (Yale University)
Villanova University
Mendel Hall, Room 213
800 Lancaster Avenue
Villanova, PA 19085
See webpage for details: http://science.widener.edu/svb/msdg/
Monday, November 12-
Wednesday, November 14
Eastern Analytical Symposium
Crowne Plaza Princeton
900 Scudders Mill Road
Plainsboro, NJ 08536
http://easinc.org/wordpress/
Wednesday, November 14
5:30 PM Networking & Appe-
tizers
7:30 PM Talk & Business Ses-
sion
Chemical Consultants Network Meeting:
CRISPR and Gene Editing Patents: Worth
the Fight? by Meg Baker – Patent Agent
McKenzie Brew House
451 Wilmington West Chester Pike
Glen Mills, PA 19343
http://chemconsultants.org/
Thursday, November 15
5:00 – 9:00 PM
Catalysis Club of Philadelphia Meeting:
How Can the Modern Scanning Trans-
mission Electron Microscope Aid Cataly-
sis Science? By Eric Stach (University of
Pennsylvania)
Crowne Plaza Wilmington North
630 Naamans Road
Claymont, DE 19703
http://catalysisclubphilly.org/current-season-monthly-meetings/
Friday, November 16
6:00 PM – 8:00 PM
2018 Ullyot Public Affairs Lecture
CRISPR Biology and Biotechnology:
The Future of Genome Editing by Dr.
Jennifer A. Doudna, University of Cali-
fornia, Berkeley
Science History Institute
315 Chestnut Street
Philadelphia, PA 19106
See webpage for details: https://www.eventbrite.com/e/ullyot-
lecture-jennifer-doudna-tickets-48708997924
Thursday, November 29
6:30 PM Social Hour
7:30 PM Seminar
Philadelphia Organic Chemists’ Club,
Pamela Haile, GlaxoSmithKline: Identifi-
cation of a first-in-class RIP2 kinase in-
hibitor in phase 1 clinical trials for im-
muno-inflammatory diseases: Small Mol-
ecules and Beyond
Chemistry Department - University of Pennsylvania
Carolyn Hoff Lynch Lecture Hall
34th and Spruce Streets
Philadelphia, PA 19104
http://www.pocclub.org/
Wednesday, December 12
9:30 AM – 2:00 PM
The Herb Bassow Memorial Chemistry
Demonstrations for Children of All Ages
Beury Hall – Temple University
1901 North 13th Street
Philadelphia, PA
March 17 – 19, 2019 PITTCON 2019
Conference and Expo
Pennsylvania Convention Center
Philadelphia, PA
Please check the individual websites for additional updated information
All content submissions are due on the 15th day of the month prior to publication