the case of ms. si
TRANSCRIPT
- 1. The Case of Ms. SI John Angelo Luigi S. Perez June 19, 2015 St. Luke's College of Medicine
- 2. 48/F Right-Handed Roman Catholic Kasambahay Old Balara, QC
- 3. Foot Numbness
- 4. History of Present Illness 2 weeks Ascending extremity paresthesia R then L LE then UE 1 week 1 day A No headache, dizziness, slurring of speech, pain. (+) pruritus, pain
- 5. History of Present Illness 2 weeks Ascending extremity paresthesia R > L LE > UE 1 week Ascending extremity weakness R > L LE > UE Tripping Steppage gait 1 day A No headache, dizziness, slurring of speech, pain. (+) pruritus, pain
- 6. History of Present Illness 2 weeks Ascending extremity paresthesia R > L LE > UE 1 week Tripping Steppage gait Legs gave way (+) Fall 1 day A No headache, dizziness, slurring of speech, pain. (+) pruritus, pain Ascending extremity weakness R > L LE > UE
- 7. Hypertensive Amlodipine, uncompliant Non-diabetic Non-asthmatic No CA Unremarkable family history
- 8. Review of Systems Palpitations Intermittent knee pains Pruritic rashes on legs Pruritic hands
- 9. Physical Examination Sallow skin Erythematous cheeks and nose PPC, AS Moist mucosa, (+) ulcers No CLADs SLE, CBS AP, no murmurs, regularly regular Flat, soft Normoactive, non-tender Pulses full and equal Grade 2 bipedal edema Multiple, hyperpigmented, lichenified lesions
- 10. MMSE Cranial Nerves I II III, IV, VI V VI VII VIII IX X XI XII Neurologic Examination Cranial Nerves
- 11. Neurologic Examination Somatic Motor 55 54 44 55 33 0 2 Good tone and bulk No fasciculations Good irritability
- 12. Neurologic Examination Tendon Reflexes +++ + ++ 0 0 (-) Toe extensor +
- 13. Neurologic Examination Somatic Sensory 90% 10% 60% 60% 10% 60% 100% 100% 30% 50% 50% 20% (+) Romberg's sign Cerebellum intact
- 14. Where do we localize the lesion? Levelize? Lateralize? Localize?
- 15. Mononeuritis Multiplex Asymmetric Asynchronous Painful Separate nerves
- 16. Salient Features Subjective Objective 48/F 2 weeks weakness and numbness Palpitations Joint pains Pruritus Stable VS Sallow skin Facial erythema Rashes Buccal ulcers Bipedal edema Mononeuritis multiplex
- 17. Mononeuritis Multiplex + Skin Lesions?
- 18. We have 3 differential diagnoses Diabetic Neuropathy Guillain-Barr Syndrome (AIDP) System Lupus Erythematosus
- 19. Diabetic Neuropathy
- 20. Guillain-Barr Syndrome (AIDP)
- 21. Systemic Lupus Erythematosus
- 22. SLE is a multisystemic disease
- 23. Neuropsychiatric SLE (NPSLE) is a recognized entity 62% 18% 8% 5% 5%1% Headache Seizures CVD Psychosis Neuropathy Movement Muscal and Brey. Neurol. Clin. 28(1) 2010
- 24. Peripheral neuropathy attributed to SLE is rare 96% 4% SLE Related Related Florica et al. Semin. Arthritis Rheum. 41(2) 2011 Asymmetry 59% Distal weakness 34%
- 25. Salient Features Subjective Objective 48/F 2 weeks weakness and numbness Palpitations Joint pains Pruritus Stable VS Sallow skin Facial erythema Rashes Buccal ulcers Bipedal edema Mononeuritis multiplex
- 26. Mononeuritis Multiplex secondary to Systemic Lupus Erythematosus
- 27. SLE is diagnosed using a set of clinical and laboratory criteria
- 28. Various autoantibodies are useful in the SLE workup Harrison's Principles of Internal Medicine, 19th Ed.
- 29. Complete Blood Count
- 30. Urinalysis
- 31. Renal Function and Electrolytes
- 32. Our patient's 2D echo showed decreased heart function EF 43/39% Hypokinesia in inferior and inferlateral wall of LV
- 33. Autoimmune Workup
- 34. Autoimmune Workup
- 35. EMG-NCV
- 36. Our patient satisfies the SLICC criteria
- 37. The pathogenesis of SLE is complex Harrison's Principles of Internal Medicine, 19th Ed.
- 38. SLE is managed according to the severity of the disease
- 39. Course in the Wards HD 1 D Guillain-Barre Syndrome HD 11 HD 5 HD 3 HD 2 HD 4 HD 7 HD 6 HD 8 HD 9 HD 10
- 40. Course in the Wards HD 1 D Guillain-Barre Syndrome HD 11 HD 5 HD 3 HD 2 HD 4 HD 7 HD 6 HD 8 HD 9 HD 10 Given IVIg Deficits fluctuated (+) fever, pruritus
- 41. Course in the Wards HD 1 D Guillain-Barre Syndrome HD 11 HD 5 HD 3 HD 2 HD 4 HD 7 HD 6 HD 8 HD 9 HD 10 Given IVIg Deficits fluctuated (+) fever, pruritus Rheuma: autoimmune workup (+) Hematuria Started on HCQ, prednisone
- 42. Course in the Wards HD 1 D Guillain-Barre Syndrome HD 11 HD 5 HD 3 HD 2 HD 4 HD 7 HD 6 HD 8 HD 9 HD 10 Given IVIg Deficits fluctuated (+) fever, pruritus Rheuma: autoimmune workup (+) Hematuria Started on HCQ, prednisone Cyclo- phosphamide
- 43. QUIZ TIME!
- 44. A patient comes to your clinic complaining of hematuria. He also admits to joint pains, reduced appetite, fever and itchy arms. On PE, you note reddish cheeks and a mouth sore. Your impression is SLE. 1. What is the first immunologic test to confirm your impression? 2. The autoantibody above turns out positive. How will you manage your patient?
- 45. SLE is managed according to the severity of the disease
- 46. Enumerate the following autoantibodies: 2. Correlates with disease activity 3. Associated with drug-induced SLE 4. Associated with lupus depression or psychosis
- 47. Various autoantibodies are useful in the SLE workup Harrison's Principles of Internal Medicine, 19th Ed.
- 48. 5. What is the most common presentation of NPSLE? 6. Give 4 SLICC criteria that permit the diagnosis of SLE.
- 49. Headaches are the most common presentation of NPSLE 62% 18% 8% 5% 5%1% Headache Seizures CVD Psychosis Neuropathy Movement Muscal and Brey. Neurol. Clin. 28(1) 2010
- 50. SLE is diagnosed using a set of clinical and laboratory criteria
- 51. Today's Learning Points
- 52. Questions?