the benefits and considerations of using therapeutic essential oils in cancer care
TRANSCRIPT
![Page 1: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/1.jpg)
Your Presenter: Luana DeAngelisYour Presenter: Luana DeAngelis
Director, Founder, Patient Navigator:
•2x Breast cancer survivor•Generational background in
Natural Health•Founder/Executive Director:
You Can Thrive! Foundation•Often called as an expert by large
media outlets•Passionate about holistic methods
![Page 2: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/2.jpg)
Disclosure:I will discuss investigational use in my presentation.
I have no conflicts of interest to disclose:For full disclosure You Can Thrive! receives a product grant from Young Living Oils since 2008. I am also an independent distributor of essential oils.
Founder/Director of: You Can Thrive!
The Benefits and Considerations of Using Therapeutic
Essential Oils in Cancer Care
![Page 3: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/3.jpg)
Disclosure:Statements made on this presentation are generally pertaining to Young Living Essential Oils. Statements and data have not been evaluated by the FDA. These products and information are not intended to diagnose, treat, cure or prevent any disease. Anyone suffering from disease or injury should consult with a physician. If you are currently on medication, please DO NOT STOP.
These compounds are meant to support your health only.
The Benefits and Considerations of Using Therapeutic
Essential Oils in Cancer Care
![Page 4: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/4.jpg)
SummaryThis presentation will provide an overview of therapeutic grade essential oils and their efficacy to both detoxify and promote health in the body as a whole.
• History• How oils are produced• What makes oils effective• Basic science• Promising data • Additional uses for the oils • Q&A at the end of the presentation.
![Page 5: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/5.jpg)
• WWII: Dr. Jean Valet used essentials oils to treat soldiers
• 1950’s: Marguerite Maury was first to give prescribed combinations
• Late 70’s early 80’s: essentials oils became major part of alternative holistic health systems
“Aromatherapy” first coined in 1937 by the French chemist and perfumer Rene Maurice Gattefosse.
Modern Medicine Aromatherapy
![Page 6: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/6.jpg)
• “Life Blood” of the plants they were harvested from.
• Principally composed of classic organic compounds
• Extremely Concentrated: one drop contains 40 million-trillion molecules.
What Are Essential Oils?What Are Essential Oils?
![Page 7: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/7.jpg)
Why are Essential Oils Why are Essential Oils So Effective?So Effective?
Ripple Effect: Takes one molecule to open the right receptor and communicate with the DNA to alter cellular function.
Our bodies know exactly what to do with these oils; the body uses what it needs and rejects the rest.
![Page 8: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/8.jpg)
Limbic System Delivery
![Page 9: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/9.jpg)
• Terpenes: make essential oils unique• More active compounds within essential oils contain
more isoprene unites• Main organic compound categories:
(each group exerts specific actions on human cells) • Phenylpropanoids• Monoterpenes• Sesquiterpenes • Antineoplastic
Organic ConstituentsOrganic Constituents
![Page 10: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/10.jpg)
Therapeutic GradeTherapeutic Grade
•Optimal naturally occurring blend of constituents to maximize desired effect.
•Shelf Life:•Therapeutic Grade= Forever (with exceptions)•Impure Oils= 2 year
•Can turn rancid•Tiny percentage of oils in the world are meant for
medicine.
![Page 11: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/11.jpg)
•Therapeutic Grade: •Careful monitoring process and seed selection.•Grown in areas with low concentrations of pollution •Crops managed by hand and no pesticides or fertilizers
ProductionProduction
![Page 12: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/12.jpg)
![Page 13: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/13.jpg)
Other Terms•Blocking Agent: prevent carcinogens from reaching target
sites by acting as barriers•Suppressing Agents: Suppress proteins expressed by
cancer cells that signal uncontrolled growth
Cancer | Pathways
One means of classifying inhibitors is on the basis of the time in the carcinogenic process at which they exert their inhibitory effects. Some PREVENT the formation of carcinogens.
![Page 14: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/14.jpg)
Cancer | Cellular Stress
Masayasu Jo – Taichiro Nishikawa – Yoshihisa Okada – Kanji Yamaguchi – Hironori Mitsuyoshi – Kohichiroh Yasui – Masahito Minami – Masaki Iwai – Keizo Kagawa – Yoshito Itoh – Toshikazu Yoshikawa
Oxidative stress is closely associated with tumor Angiogenesis of hepatocellular (Liver) carcinoma
ORIGINAL ARTICLE – LIVER, PANCREAS AND BILIARY TRACT
Received 22 December 2009/ Accepted 9 February 2011/ Published Online 31 March 2011
![Page 15: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/15.jpg)
ORAC Designation
![Page 16: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/16.jpg)
Prevention: the cure?
Normal course ofcancer progression
Cancer prevention
![Page 17: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/17.jpg)
.“Monoterpenes in breast cancer chemoprevention”
The multiple antitumorgenic effects of limonene are attainable at a high therapeutic ratio, suggesting that limonene and related monoterpenes may be efficacious in the chemoprevention and chemotherapy of human malignancies”.
Complete Tumor Regression –The complete regression of mammary carcinomas by limonene appears to involve tissue redifferentiation.
Breast Cancer Res Treat 1997 Nov-Dec;46(2-3):191-7 Crowell PL.
Abstract - Pub Med – National Library of Medicine / National Institutes of Health
D-Limonene (Citrus Peel Oil)D-Limonene (Citrus Peel Oil)
![Page 18: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/18.jpg)
TRdonePhase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee.D M Vigushin, G K Poon, A Boddy, J English, G W Halbert, C Pagonis, M Jarman, R C Coombes
Department of Medical Oncology, Charing Cross Hospital, London, UK. PURPOSE: D-Limonene is a natural monoterpene with pronounced chemotherapeutic activity and minimal toxicity in preclinical studies. A phase I clinical trial to assess toxicity, the maximum tolerated dose (MTD) and pharmacokinetics in patients with advanced cancer was followed by a limited phase II evaluation in breast cancer.
D-Limonene + Cancer StudiesD-Limonene + Cancer Studies
One partial response in a breast cancer patient on 8 g/m2 per day was maintained for 11 months; three patients with colorectal carcinoma had prolonged stable disease. There were no responses in the phase II study..
CONCLUSIONS: D-Limonene is well tolerated in cancer patients at doses which may have clinical activity. The favorable toxicity profile supports further clinical evaluation.
![Page 19: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/19.jpg)
Since the reactive ultimate carcinogenic forms of chemical carcinogens are electrophiles, induction of GST activity by anticarcinogenic compounds is believed to be a major mechanism for carcinogen detoxification”. “Glutathione S-transferase (GST) catalyzes the reaction of glutathione with electrophiles to form less toxic conjugates for excretion”
It appears that one way that essential oils work is through more effective detoxification.
Limonene ConsiderationsLimonene Considerations
![Page 20: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/20.jpg)
Clove| The most powerful antioxidant oil~ ORAC value of: 1,078,700 uTE/110G
Eugenol is an essential oil mainly found in the buds and leaves of clove (Syzygium aromaticum (L.)
Eugenol inhibits cell proliferation and induces apoptosis in human MCF-7 breast cancer cells (in vitro).
The biological activities of Eugenol in human breast cancer cells can be correlated to its potential activity as an estrogen receptor (ER) antagonist.
![Page 21: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/21.jpg)
Results of Therapeutic Oils Studied In Results of Therapeutic Oils Studied In Human Cancer Cell LinesHuman Cancer Cell Lines
60 Oils Tested for their anti-cancer activity. Results for oils that inhibit cancer growth in-vitro with low normal cell toxicity
BREAST CANCERConcentration (parts
per million)% Cell
Inhibition
Sandalwood 100 ppm 98.10Myrtle 200 ppm 95.20Tsuga 200 ppm 93.10
![Page 22: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/22.jpg)
Symptom Relief• Neuropathy – Frankincense/Peppermint/ reflexology• Hot Flashes – Peppermint on back on neck• Fatigue – Peppermint – inhaled and on temples• Pain- Peppermint topically• Chemobrain- Peppermint• Depression - Orange• Anxiety an array of oils almost any oil will help anxiety• Nausea- Ginger, peppermint, Fennel inhaled and/or on tongue• Insomnia- valerian, lavender• Courage- Frankincense, Tansy, Rosewood,
![Page 23: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/23.jpg)
Internal & Experimental Use• Certain oils can be used internally as part of a
regimen for maintaining health
• Quality is imperative
• Consult with a professional
EXPERIMENTAL USE: • In some places in the world essential oils are being
diluted and used intravenously
![Page 24: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/24.jpg)
Therapeutic GradeCan Promote health: •Fatigue•Pain•Cellular Oxidation•Hot flashes•Lymphadema•Hormone Imbalance•Anxiety•Nausea
• Non-toxic• Safe in clinical settings• Safe for internal use
![Page 25: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/25.jpg)
![Page 26: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/26.jpg)
Peppermint Oil
Peppermint oil like the ‘Swiss army knife” of oils and can be used with a multitude of symptoms to promote health amidst the side effects that accompany many conventional treatment protocols.
![Page 27: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/27.jpg)
EmotionalEmotional Benefits BenefitsLessen AnxietyReduce Stress Diminish FearEase DepressionIncrease Feelings of HopeEnhance Sense of
Empowerment
Lavender, Valerian, ChamomileLavender, so many othersValerian, Tansy, FrankincenseJasmine, FrankincenseSandalwoodPepper, Sage, Nutmeg
![Page 28: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/28.jpg)
Reduce FatigueMitigate Nausea Alleviate PainImprove SleepModerate Symptoms of NeuropathyEnhance Mental Clarity
Physical BenefitsPhysical BenefitsJuniper, Cypress, ThymePeppermint Peppermint, WintergreenValerian, LavenderPeppermint, Frankincense Geranium, CypressPeppermint, Rosemary, Lemon
![Page 29: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/29.jpg)
Traditional Uses include:
•Rubbing on forehead, temples, and/or back of neck traditionally used for headaches and hot flashes
•Inhaled & Internally nausea, dizziness or simple halitosis
•Apply topically to alleviate pain
•Diffuse, inhale to improve concentration
•Apply over stomach or ingest to promote healthy digestion
•Rub on bottoms of feet and armpits/groin to soothe fever
Folk Uses for PeppermintFolk Uses for Peppermint
![Page 30: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/30.jpg)
New species of frankincense dubbed “sacra” have been found to have a different and more potent form of Boswellic acid compounds..
FrankincenseFrankincense
![Page 31: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/31.jpg)
FrankincenseFrankincensecan provide cancer-specific cell death
![Page 32: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/32.jpg)
Activates genes responsible for suppressed cancer cell growth and elevated cancer cell death
Frankincense & OncogenesFrankincense & Oncogenes
Gene Symbol
Time after frankincense oil exposure(hours)
0 <0.5 0.5-1 1-2 2-3
IL8 26.3 32.6 146.2 693.6 1241.4
CLK1 42.3 56.1 57.9 121.2 203.3
DLG1 48.3 41.2 31.2 71.8 37.2
H2AFX 105.6 103.3 106.6 51.0 96.1
ING4 73.7 63.0 75.3 37.2 43.6
KLF4 89.2 68.8 123.2 326.0 556.9
NEDD9 38.3 34.3 23.8 59.7 56.7
SSTR1 47.4 37.2 28.4 70.3 27.2
CDKN1A 56.3 54.5 95.7 167.4 382.9
DDIT3 346.7 316.0 523.2 735.5 1647.7
HDAC4 64.4 61.7 52.1 68.0 31.5
IL1A 63.4 44.5 72.1 124.5 252.5
IL6 190.5 235.4 337.2 563.8 1326.4
SNF1LK 40.6 38.8 48.9 95.8 286.3
IL8 26.3 32.6 146.2 693.6 1241.4
CLK1 42.3 56.1 57.9 121.2 203.3
DLG1 48.3 41.2 31.2 71.8 37.2
Gro
wth
inh
ibito
ry g
enes
Cell death genes
![Page 33: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/33.jpg)
FrankincenseFrankincense && Pancreatic CancerPancreatic CancerPurpose“Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model.
Conclusion“All fractions of Frankincense essential oil from Boswellia sacra are capable of suppressing viability and inducing apoptosis of a panel of human pancreatic cancer cell lines.”
BMC Complement Altern Med. 2012 Dec 13;12:253. doi: 10.1186/1472-6882-12-253.
Ni X1, Suhail MM, Yang Q, Cao A, Fung KM, Postier RG, Woolley C, Young G, Zhang J, Lin HK.Author information1Department of General Surgery, Long Hua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
![Page 34: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/34.jpg)
Library/IDArea (%)
78 oC 0-2 hr 78 oC 9-10 hr 78 oC 0-12 hr 100 oC 12 hr
trans-beta-caryophyllene 0.02 0.02 0.28 0.62
alpha-humulene 0.03 0.01 0.11 0.17
allo-aromadendrene 0.02 0.06
gamma-muurolene 0.01 0.05 0.10
germacrene D 0.02 0.09
beta-selinene 0.01 0.02 0.21 0.45
alpha-selinene 0.02 0.01 0.12 0.24
gamma-cadinene 0.04 0.07
delta-cadinene 0.01 0.05 0.14
caryophyllene oxide 0.02 0.05
trans-beta-caryophyllene 0.02 0.02 0.28 0.62
Temperature DistillationTemperature DistillationChemical components depend on duration and temperature of distillationChemical components depend on duration and temperature of distillation
![Page 35: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/35.jpg)
Frankincense & Breast CancerFrankincense & Breast CancerPurpose“Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells”
Conclusion“Boswellia sacra essential oil represses signaling pathways and cell cycle regulators that have been proposed as therapeutic targets for breast cancer”
BMC Complement Altern Med. 2011 Dec 15;11:129. doi: 10.1186/1472-6882-11-129.
Suhail MM1, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin HK.Author information1Al Afia Medical Complex, Salalah, Sultanate of Oman.
![Page 36: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/36.jpg)
• Essential oils are a beneficial, if not critical component of any holistic approach to caring for, or staying healthy in the face of serious illness.
• Essential oils can be beneficial both physically and emotionally to enhance mental capacity to deal with stress and illness.
• More research is needed in human subjects to determine their use as treatment or adjunct prevention methods for cancer.
Conclusion
![Page 37: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/37.jpg)
Thrive!Now get out there and
![Page 38: The Benefits and Considerations of Using Therapeutic Essential Oils in Cancer Care](https://reader034.vdocuments.us/reader034/viewer/2022051706/58ef7f091a28abfd3f8b460f/html5/thumbnails/38.jpg)
Questions?Disclosure:Statements made on this presentation are generally pertaining to Young Living Essential Oils. Statements and data have not been evaluated by the FDA. These products and information are not intended to diagnose, treat, cure or prevent any disease. Anyone suffering from disease or injury should consult with a physician. If you are currently on medication, please DO NOT STOP.
These compounds are meant to support your health only