the artist as scientist - the sonification of dna
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Increased online accessibility to information in mathematics, genetics, acoustics and myriad other scientific fields has resulted in the blurring of lines between art and science. An example of this evolution can be seen in artists and composers creating music utilizing quantified DNA and protein information through the process of data sonification.TRANSCRIPT
Kyle Evans
The Artist as Scientist: The Sonification of DNA
2009
Increased online accessibility to information in mathematics, genetics,
acoustics and myriad other scientific fields has resulted in the blurring of lines
between art and science. An example of this evolution can be seen in artists and
composers creating music utilizing quantified DNA and protein information
through the process of data sonification. According to the International
Community for Auditory Display, “Sonification is the use of non-speech audio to
convey information.”1 The ideas and practices of DNA sonification are not only
fundamentally based in biotechnology and genetics, but were initially conceived
by scientists in the field of research. This initiation point creates a platform from
which ideas and concepts can be transposed from the world of science into that
of art and music. As the field of biotechnology develops, and the information it
produces becomes increasingly more attainable, it is understandable that
composers and sonic artists would adopt this information into their own
practices and utilize the data for artistic means. This displacement of data from
one field of study to another spawns a dichotomy between the artist/composer
and the scientist/biologist. This dichotomy weighs heavily in defining the role of
the composer in the artistic process. Analyzing the merger of quantified
scientific data and musical composition is an important concept in the practice
of DNA sonification. Does a composer choose to fill the role of scientist and
utilize the process for research and scientific development, or does the
composer take on the role of artist and utilize the data produced by the scientist
to generate work with a focus on musical aesthetics? How accurately can data
derived from DNA sequences be reproduced?
The sonification of extra-musical measurements is a practice that has its
roots firmly grounded in the recent history of avant-garde composition. Though
not an extremely popular form of composition, sonification has been
successfully practiced through many techniques and approaches. In 1970,
Charles Dodge composed Earth’s Magnetic Field, which explores musical
representation of collected Kp index data; an average measurement of the
subtle changes in the earths magnetic field. In 1962, John Cage composed Atlas
Eclipticaias by using star charts superimposed with sheet music. In this process,
Cage not only exploits the random organization of stars to generate aleatoric
sequences of pitch and rhythm, but also utilized each star’s relative brightness
to signify the amplitude of each note. In pieces such as these, there exists a
fascinating juxtaposition of two fields of studies which, when merged, can
create unexpected alternative outcomes. Though the two pieces mentioned
above were created by composers and not by scientists, many scientists in the
area of genetics have attempted to solve the complexities concerning DNA
representation by taking on the help of composers and musicians to sonify the
complicated data structures into a more retainable and interesting medium. In
the opening statement of an article written by Andi Schoon and Florian
Dombois, this separation of scientific and artistic approach is explained and
applied to all forms of exta-musical data sonification:
“Seen from the vantage point of cultural history, contemporary sonification is
essentially characterized by two aspects that to date have seldom been considered in combination: the first aspect is sonification as the transformation of the inaudible into the sphere of the audible, and the second its use as an
instrument for gaining knowledge via the concrete listening experience.” 2 (Andi Schoon, Florian Dombois, 2009)
This statement introduces the two greatly differing approaches that scientists
and artists take, and the proportionally differing results of the sonified DNA data.
The connection between DNA sequence data and musical notation are
not immediately recognizable, but through study and examination it is possible
to find many different ways that the two can combine. The most immediate
realization of musical connection is the serialization of data that is used in
representing DNA sequences. For example, DNA is encoded using four base
types; adenine, cytosine, thymine, and guanine (A,C,T and G). These bases are
then combined into sets of three generating what is called a codon (AGT, TTC,
AGA, etc). This massive collection of potential combinations can portray many
parallels to melody and rhythm when an artist uses the data to represent
musical properties such as pitch, loudness, duration, timber, etc. Beyond this
“language” that represents basic DNA structures, composers have also utilized
other genetic measurements to incorporate in the sonification process including,
water solubility, Pk(a) and pH measurements, molecular weight, folding patterns
and even light absorption levels. Due to a continued public interest in
biotechnology and increases in data accessibility of modern times, there now
exists a plethora of representational genetic data that composers and musicians
have readily available at their disposal. With this wide-open access to genetic
data, many technical and conceptual challenges arise. Where is an artist to
begin?
Different musicians and scientists have approached this issue with greatly
differing methodologies. The artist must make aesthetic and conceptual
decisions as how to translate incredibly large amounts of data. But how does an
artist represent sonically that which is meant to represent something else? DNA
sequences naturally exist outside the realm of numerical value, but science has
chosen to represent these sequences as data strings in order to help our minds
decipher the complexity of the biological information. These methods of DNA
representation were created by scientists for scientists, which in turn, forms an
obstacle the composer must first encounter before any aesthetic or artistic
decisions can be made; should the process be approached from the
perspective of an artist or that of a scientist. Of course, a combination of both
must exist in order to use scientific data for musical composition, but the weight
of scientific or artistic approach usually lies in the practice of the composer.
An example of the separations and interconnections between scientist
and artist can be seen in comparing the practices and works of John Dunn and
Marry Anne Clark. The two began collaborating in the 1980’s with investigations
into DNA sonification. John Dunn, as a musician and artist, required the help of
a scientist, Marry Anne Clark, to develop the techniques and methods of
translating DNA sequences into the acoustic realm. The two generated methods
involving the translation of amino acids into frequencies on a traditional western
musical scale, and eventually added more complexity by utilizing data collected
from water solubility measurements and folding patterns. Their relationship, as
documented in a co-written article by Dunn and Clark entitled Life Music: The
Sonification of Proteins, shows the dichotomy of science and art through a
verbal exchange between the two; Dunn asks Clark, “Where is the art in your
science?” in which Clark responds by asking, “Where is the science in your
art?” 3 (Dunn and Clark)
Interestingly enough, it was the work of scientists, solely for the reasons
of research and teaching that the first experiments in DNA sonification practices
surfaced. Scientists Kenshi Hayashi and Nobuo Munakata suggest the approach
in their writing Basically Musical in 1984:
“Recent progress in gene cloning and DNA sequencing techniques has produced an enormous amount of base sequence data. …We propose an acoustic method to minimize the distress of handling such information. …One certain advantage of this method is that the sequences are now more easily recognized and memorized. … This practice may help to bring back some of the pleasure of decoding the mysteries of life from computers.” 4 (Hayashi and
Mankau, 1984)
As well as Hayashi and Mankau, N. Munakata has also been exploring the
scientific frontier of DNA sonification. Munakata approached the concept with
the notion that musical tunes are easier and more pleasant to memorize than
alphanumeric strings of bases and amino acids. Through this process, he
attempts to “reveal the meaning of specific sequences of DNA bases.”5 His
technique involved assigning pitches to DNA bases according to their thermal
stability. In Munakata’s words,
“Genes and music are two heritable systems that underlie our life. Both of them are made of linear and quantized information. I try to explore the correspondence and metaphor between them by converting gene (DNA, RNA and protein) sequences to MIDI sequences. Hopefully, gene music can capture
and inspire appreciation of the diversity, mystery and beauty of life.” 6 (Munakata)
Though his methods are slightly more intricate than those of Hayashi and
Mankau, he still limits his results to common western musical scales, therefore
limiting any distinction from other musical work. The restriction to scale
structures in attempts to make the sonified patterns of DNA more “listenable” is
a common practice among many composers. This shows the strong role the
composer can play in a process whose data sources exist beyond the
composer’s control. If the method in which the DNA is sonified has the ability to
structure a score due completely to the composer’s personal aesthetic opinions,
then does the result any longer represent a DNA sequence? Or does it then only
represent the composer?
This role of the composer can be heard very clearly in the work of John
Dunn and Marry Anne Clark. Each separately composed a piece from base
sequences collected of the enzyme lysozyme C. When listening to each artist’s
personal sonification of the enzyme, it becomes very clear the large amount of
liberties a composer can take in the process. Dunn’s thunderous sounds and
sharply pronounced rhythms of his rendition stand in stark contrast to the
cheerful, light hearted and floating melodies of Clark’s version. Dunn and Clark
describe their first time hearing the two radically differing pieces:
“… The experience of listening to these parallel compositions, each developed independently in two different locations (Clark in Texas and Dunn in Michigan), but with the same protein data… gave more insight into the astounding depth of structure Nature has built into Her art.” 3 (Dunn and Clark)
In this case, Clark and Dunn give reason for the two Lysozyme C pieces
being so different to the openness of the DNA sequences themselves.
Therefore, practical aesthetic choices become the only limitation on such an
open structure which, of course, is the case for all types of data sonification. In
this mindset, if a DNA musical score is without any type of compositional
control, the large amounts of data that can be collected from the multitude of
available DNA and protein sequences appears too versatile to be truthfully
represented. Most composers who practice DNA sonification share this view
and sometimes use it to justify radical aesthetic decisions. Three researchers, X.
J. Shi, Y. Y. Cai and C. W. Chan looked closely at the representative issues of
DNA sonification to its original data sets and have come to some rather steep
conclusions. In discussing the transposition of DNA data into the acoustic realm,
they write:
“This is like translating English into Chinese. In cases where direct translation cannot express the original message clearly, the translator needs to look at the context and decide on a similar Chinese expression. This flexibility is equally necessary in translation between proteins and music. …Instead of sonifying the amino acid according to their solubility, we sonified according to aesthetic appeal…” 5 (Shi, Cai and Chan)
When this method of sonification is applied toward DNA sequence data,
then there exists no connection between the composer’s results and what the
source information actually represents. If this connection is forgotten then there
is no reason to claim that results of this type are representations of the materials
supplied to us by nature.
Since the information that we can collect from DNA and protein
sequences are so open ended in terms of musical interpretation, it is difficult to
imagine a truly successful realistic representation. If a composer’s intention is to
represent the source of data from which a musical piece is sonified, then the
creator must consider a realistic (or even scientific in the case of DNA)
connection between the two. Artists such as Susan Alexjander and Peter Gena
are some of the few composers who have focused on this approach of a more
truthful representation by utilizing science and math.
Susan Alexjander utilizes a unique set of data found in DNA sequences
that help to create a more physical attachment to the music that the information
produces. By calculating the light absorption frequencies of bases, Alexjander is
able to connect the data to sound through their shared measurement; cycles per
second. Through the Law of the Octave, these extremely high light frequencies
are repeatedly divided in half until their frequency resides within the range of
human hearing.7 Dividing these frequencies does not result in the “comfortable”
tonal scale that we have been conditioned to recognize, but instead creates
microtonal pitches. These microtonal pitches are not rounded in order to match
any particular scale, in turn resulting in a more truthful representation of the
original measurements.
Along with Susan Alexjander, Peter Gena’s DNA sonification work
depends significantly on the idea of truthful representation by utilizing complex
algorithms. Gena, with help of geneticist Charles Strom, has created computer
software he calls The DNA Mixer, which can translate the information of DNA
sequences into sound in real-time. The composer himself best describes his
intentions:
“…I believe that the musical reading of DNA ought to be rendered literally. As the sequences represent life of many sorts, I am reluctant to tamper with the ‘score’. The DNA mixer can realize sequences as digital sound and/or prints them out in musical notation. …The Physio-musical conversation of DNA sequences takes place via a series of formulae that were worked out in a manner based on physical properties of DNA and musical parameters.” 8 (Gena and Strom)
Gena’s method goes beyond just representing different bases as different
frequencies; he uses myriad physical characteristics of amino acids in order to
recreate not only pitch, but also timber, amplitude and duration. His algorithms
for generating the musical information involve data obtained from sequences not
commonly being utilized by other composers. He takes into account Pk(a)
acidity measurements, molecular weight and chemical properties of each amino
acid represented. Just as in John Cage’s sonification of star charts, Gena
composes for more than just one musical dimension. By taking timbre and
dynamics into consideration, he has discovered a way to more truthfully
represent the data supplied by DNA and maintain aesthetically interesting
results.
The composers and scientists presented here only represent a small
portion of the total who are exploring DNA sonification, but they demonstrate
the vastly differing approaches and results that can come about through the
process. Though there always exists a role the artist must play in the sonification
of such an extensive data structure as DNA, there also exists the possibility of
creating strong physical and conceptual attachments to the original source
material. Artists such as Susan Alexjander and Peter Gena show in their work
that this connection is not only appropriate in representing something of such
scientific importance as DNA, but also have the ability to generate aesthetically
interesting results. What is most interesting in the sonification process, most
particularly that of DNA data, is the hybridization of artist and scientist. These
roles have become blurred as our access to scientific data becomes
increasingly available. As scientific information and understanding develops, so
will the approaches and techniques that further push the connections between
science and the methods in which artists choose to interpret its information.
These approaches, designed by artists and scientists alike, are transforming the
conceptual connections an artist can explore between the two practices. DNA
sonification only represents one methodology for artists to utilize within the
endless possibilities for the artistic interpretation of science.
Works Cited
1. International Community for Auditory Display. Sonification Report:Status
of the Field and Research Agenda. (Prepared for The National Science
Foundation, 1997)
2. Andi Schoon and Florian Dombois. Sonification in Music. Proceedings of
the 15th International Conference on Auditory Display. Copenhagen 2009.
3. M. A. Clark and John Dunn. “Life Music: The Sonification of Proteins”.
Leonardo, Vol. 32, No. 1. (1999).
4. Kenshi Hayashi and Nobuo Munakata. “Basically Musical”. Nature. 310
(1984).
5. X. J. Shi, Y. Y. Cai and C. W. Chan. “Electronic Music for Bio-Molecules
Using Short Musical Phrases”. Leonardo, Vol. 40, No. 2 (2007)
6. Nobuo Munakata. Gene Music and Sangen Studio.
http://www.toshima.ne.jp/~edogiku/index.html#WhatIsGM
7. Susan Alexjander. “Microcosmic Music – A New Level of Intensity”.
Online Article. Our Sound Universe.
http://www.oursounduniverse.com/articles/microcosmic.html
8. Peter Gena and Charles Strom. “A Physiological Approach to DNA
Music.” Online Article. http://www.petergena.com/docs/gena-strom-
DNA.pdf (2001)