the 4 arrows - aldosterone action-nw2017
TRANSCRIPT
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Kidney: Juxtaglomerular
(JG) cells Kidney: Juxtaglomerular
(JG) cells
Fall in renal perfusion pressureRenin
Renin
Fall in blood volume
and/or pressure
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Renin Renin
Increased sympathetic discharge
Baroreceptor reflex
Increased sympathetic discharge
Fall in blood volume
and/or pressure
Kidney: Juxtaglomerular
(JG) cells
Kidney: Juxtaglomerular
(JG) cells
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Renin Renin
Angiotensinogen Angiotensin I
Angiotensin II
Angiotensin Coverting Enzyme
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Aldoster
one
Angiotensin II
Adrenal
Cortex
Adrenal
Cortex
Aldoster
one
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Aldoster
one
High plasma
K+ levels
Adrenal
Cortex
Adrenal
Cortex
Aldoster
one
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Aldoster
one
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Aldostero
neC o l l e c t i n g d u c t c e l l s
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4 arrows
T u b u l a r f l u i d I n t e r s t i t i a l f l u i d B l o o d
Aldoster
one
Action
H2O
Na+
K+
H+or
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4 arrows
T u b u l a r f l u i d I n t e r s t i t i a l f l u i d B l o o d
Aldoster
one
Action
H2O
Na+
K+
H+or
H2O
Na+
K+
Blood volume blood pressure
Regulation of
plasma
potassium levels
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4 arrows
T u b u l a r f l u i d I n t e r s t i t i a l f l u i d B l o o d
Aldoster
one
Action
H2O
Na+
K+
H+or
H2O
Na+
K+
Blood volume blood pressure
Regulation of
plasma
potassium levels
Conn’s syndrome (Primary hyperaldosteronism)
Hypervolemia
Hypertension
Hypokalemia
Metabolic alkalosis
[H+]
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Conn’s syndrome (Primary hyperaldosteronism)
HypervolemiaHypertension
Metabolic alkalosis
Hypokalemia
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HypovolemiaHypotension
Hyperkalemia
Metabolic acidosis
Addison’s Disease(Primary hypo-aldosteronism)
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HypovolemiaHypotension
Hyperkalemia
Metabolic acidosis
Addison’s Disease(Primary hypo-aldosteronism)