the 3 rd annual emerging information technology...

Th e 3 rd An n u a l Em ergin g In form a tion Tech n ology Con feren ce

Na n otech n ology, MEMS,

Sys tem -on -Ch ip , Bioin form a t ics ,

C4I Works h ops

October 31 - Novem ber 1 , 2003 , Friend Cen ter, Princeton Un ivers ity ,

Princeton , New Jers y , U.S .A.

Th e 3 rd An n u a l Em ergin g In form a tion Tech n ology Con feren ce - Oct 3 1 -Nov 1 , 2 0 0 3 , Pr in ceton , NJ , USA ==============================================================================================================

2

Table o f Con t e n t s

WELCOME MESSAGE ............................................................................................................................................ 3

CONFERENCE THEMES......................................................................................................................................... 4 NANOTECHNOLOGY WORKSHOP ................................................................................................................................ 4 MEMS WORKSHOP ................................................................................................................................................... 4 SYSTEM ON CHIP WORKSHOP .................................................................................................................................... 5 BIOINFORMATICS WORKSHOP .................................................................................................................................... 5 CONTENT, COMPUTER, COMMUNICATIONS, CONSUMER ELECTRONICS, AND INTEGRATION (C4I) WORKSHOP......... 6

PLANNING COMMITTEE....................................................................................................................................... 8 CONFERENCE ORGANIZING ASSOCIATIONS ................................................................................................................ 8 EXECUTIVE SECRETARY ............................................................................................................................................ 8 CONFERENCE SPONSORS............................................................................................................................................ 8 CONFERENCE PLANNING COMMITTEE........................................................................................................................ 8

CONFERENCE PROGRAM................................................................................................................................... 12 DAY 1 (OCTOBER 31, 2003) .................................................................................................................................... 13 DAY 2 (NOVEMBER 1, 2003) ................................................................................................................................... 16

ABSTRACTS AND BIOGRAPHIES ...................................................................................................................... 19 CONFERENCE ORGANIZERS...................................................................................................................................... 19 CONFERENCE CHAIRS .............................................................................................................................................. 21 CONFERENCE PROGRAM CHAIRS ............................................................................................................................. 23 CONFERENCE COORDINATORS ................................................................................................................................. 28 DAY1 ....................................................................................................................................................................... 30

Key note S peech .............................................................................................................................................. 30 P1 - Plenary S es s ion 1 : Nanotechnology .................................................................................................. 32 P2 - Plenary S es s ion 2 : MEMS .................................................................................................................... 36 T1 - Technical S es s ion 1 : Nanotechnology (I).......................................................................................... 39 T2 - Technical S es s ion 2 : MEMS (I)............................................................................................................ 44 T3 - Technical S es s ion 3 : S y s tem -on-Chip (S oC) (I)............................................................................... 48 T4 - Technical S es s ion 4 : B ioin form atics (I)............................................................................................. 56 T5 - Technical S es s ion 5 : C4I (I): IT and Bus ines s Proces s Outs ourcing ......................................... 59 T6 - Technical S es s ion 6 : Nanotechnology (II)......................................................................................... 64 T7 - Technical S es s ion 7 : MEMS (II)........................................................................................................... 72 T8 - Technical S es s ion 8 : S y s tem -on-Chip (II)......................................................................................... 78 T9 - Technical S es s ion 9 : B ioin form atics (II) ........................................................................................... 83 T10 - Technical S es s ion 10: C4I(II): On Dem and Com puting Technologies ..................................... 85

DAY2 ....................................................................................................................................................................... 92 Key note S peech .............................................................................................................................................. 92 P3 - Plenary S es s ion 3 : S y s tem -on-Chip .................................................................................................. 94 P4 - Plenary S es s ion 4 : B ioin form atics ..................................................................................................... 98 T11 - Technical S es s ion 11: S y s tem -on-Chip (III)................................................................................. 103 T12 - Technical S es s ion 12: B ioin form atics (III) ................................................................................... 109 T13 - Technical S es s ion 13: C4I (III): Multi-S ervice Com m unications ............................................. 114 T14 - Technical S es s ion 14: C4I (IV): In form ation and Know led ge Managem ent........................ 120 T15 - Technical S es s ion 15: S y s tem -on-Chip (IV) ................................................................................ 125 T16 - Technical S es s ion 16: B ioin form atics (IV)................................................................................... 132 T17 - Technical S es s ion 17: C4I (V): Ubiqu itous Com m unications and Com puting .................... 138 T18 - Technical S es s ion 18: C4I(VI): Hum an-Com puter In tegration ................................................ 146


3

Welcome Message It is ou r p lea s u re to welcom e you to th e Em ergin g In form a t ion Tech n ology Con feren ce, EITC 2003 . Th is con feren ce is h eld a n n u a lly to fa cilita te in form a t ion exch a n ge a m on g profes s ion a ls from th e Pa cific Rim a n d Nor th Am er ica on n ew in form a t ion tech n ologies . It s ob ject ives a re to s t ren gth en th e tech n ica l a n d bu s in es s t ies between th e Pa cific Rim a n d Nor th Am er ica n in form a t ion tech n ology in du s t r ies , to b r in g togeth er exper ts a n d in du s t ry lea ders to s h a re tech n ologica l a dva n cem en ts a n d bu s in es s exper ien ces , a n d to join t ly exp lore oppor tu n it ies in em ergin g in form a t ion tech n ologies . Th e orga n izin g com m it tee, u n der th e ca pa b le lea ders h ip of Mich a el Hwa Ha n Wa n g, h a s a ga in pu t togeth er a very in teres t in g a n d eclect ic p rogra m . Th is yea r , we h a ve a dded a n ew progra m t r a ck , ca lled C4I, wh ich s ta n ds for “Con ten t , Com pu ter , Com m u n ica t ion s , Con s u m er Elect ron ics , a n d In tegra t ion ”. Th is is in a dd it ion to th e fou r p rogra m t ra cks we h a d la s t yea r in Na n otech n ology, MEMS, Sys tem on a Ch ip (SOC) a n d Bioin form a t ics . In tota l, we h a ve 18 tech n ica l s es s ion s in pa ra llel t ra cks , fou r p len a ry s es s ion s a n d two keyn otes . On beh a lf of th e orga n izin g com m it tee, in clu d in g con feren ce orga n izers Ts u -Ha n Ch en a n d Su n -Yu a n Ku n g, we wou ld like to th a n k th e p rogra m t ra ck ch a ir s for th eir ou ts ta n d in g effor ts in pu t t in g togeth er th is p rogra m . Th ey a re Ch i-Ch a n g Ka o (Na n otech n ology), Da r r in J . You n g (MEMS), Howa rd Ch en (SoC), Su e-J a n e Wa n g (Bioin form a t ics ) a n d Ron g Ch a n g (C4I). Th e work of th e orga n izin g com m it tee wa s pa r t icu la r ly d ifficu lt th is yea r beca u s e of th e SARS ep idem ic. Th is ca u s ed grea t u n cer ta in ty a s to wh eth er EITC cou ld even be h eld th is yea r . For tu n a tely, SARS a ppea red to be u n der con t rol by th e en d of th e s u m m er , a n d we decided to p roceed a s p la n n ed . Ma n y th a n ks to a ll in volved for th eir pa t ien ce a n d pers evera n ce. Th is yea r , we a ls o m ou rn th e s u dden dea th of a key m em ber of th e EITC tea m , Dr . Mow Lin , wh o wa s th e con feren ce co-orga n izer of EITC 2003 . Dr . Lin wa s a d is t in gu is h ed s cien t is t a t th e En ergy Scien ces a n d Tech n ology Depa r tm en t a t Brookh a ven Na t ion a l La bora tor ies . Mow wa s a ls o a very a ct ive pa r tn er for m a n y tech n ica l a ct ivit ies , a n d will be fon d ly m is s ed . We wis h to th a n k ou r m a jor s pon s ors , th e In ves tm en t & Tra de Office a n d th e Scien ce Divis ion , TECRO. We th a n k th e en t ire EITC tea m for pu t t in g togeth er th is excellen t p rogra m with s o m a n y tech n ica l exper ts a n d in du s t r ia l lea ders from both s ides of th e Pa cific. We a ls o wa n t to expres s ou r a pprecia t ion to a ll th e s pea kers for p repa r in g th eir ta lks a n d com in g to s h a re th eir exper t is e. La s t , bu t n ot lea s t , we th a n k th e Ch in es e Stu den t As s ocia t ion s for th eir en th u s ia s t ic h elp in th e loca l a r ra n gem en ts for EITC 2003 a t th e Pr in ceton Un ivers ity ca m pu s . En joy th e con feren ce, a n d en joy you r vis it to Pr in ceton ! Ru by Lee, Pr in ceton Un ivers ity Con feren ce Co-Ch a ir Ch in ta y Sh ih , In du s t r ia l Tech n ology Res ea rch In s t itu te Con feren ce Co-Ch a ir


4

Conference Themes

Nanotechnology Workshop Na n otech n ology, em ergin g from n a n os cien ce a n d n a n oen gin eer in g is expected to lea d th e n ext in du s t r ia l revolu t ion th rou gh th e 21 s t cen tu ry. It is t in y, on th e s ca le of on e b illion th of a m eter (n a n o-m eter or n m ), yet it s im pa ct on ou r life will be t rem en dou s . It is expected to ch a n ge everyth in g from a gr icu ltu re to m edicin e a n d from elect ron ics to m ech a n ics . Na n om eter s ca led devices a re im a gin ed to be th e s m a lles t a n d fa s tes t com pu ter , s m a r t a n d poten t m edicin e, a n d s elf-rep lica t in g m a ch in es . Two a pproa ch es a re bein g a dopted to fa br ica te th es e devices . Th e top-down proces s s u ch a s to s h r in k th e MEMS to NEMS a n d th e bot tom -u p a pproa ch by s yn th es izin g n a n o- pa r ts via s elf-a s s em bly p roces s . Th ere is a n in ten s e in teres t in Na n otech n ology s tem m in g from th e fa ct th a t developed cou n t r ies a n d vis ion a ry bu s in es s es a re ru s h in g to in ves t a n d ta k in g a lea d in g pos it ion in . Addit ion a lly th is va s t fron t ier tech n ology is open to ch em is ts , ph ys icis t s , m olecu la r b iologis ts , m a ter ia l s cien t is t s , en gin eers a n d litera lly a n yon e with n ew idea s a n d a wa n t to exp lore a n d d is cover . If you h a ve a th ir s t for exp lora t ion a n d wis h to m a ke you r m a rk in s cien ce h is tory, join u s to lea rn m ore, m a ke con ta cts , a n d s h a re idea s with oth er exper ts in th is b ra n d n ew field .

MEMS Workshop Microelect rom ech a n ica l s ys tem s (MEMS) is a n en a b lin g tech n ology th a t will poten t ia lly im pa ct th e econ om y a n d s ociety every b it a s m u ch a s m icroelect ron ics h a ve th es e pa s t few deca des . S ilicon in tegra ted-circu it fa br ica t ion tech n ology, th rou gh th e p ra ct ice of ba tch fa br ica t ion a n d redu ct ion of s ca le, revolu t ion ized th e elect ron ics in du s t ry. Applyin g th es e s a m e pr in cip les a n d s im ila r tech n ologies to MEMS, th e fu tu re s h a ll b r in g m icros ys tem s in th e op t ica l, ch em ica l, b iologica l, elect r ica l or m ech a n ica l dom a in s th a t will crea te n ew a n d u n fores een m a rkets . Alrea dy, MEMS produ cts h a ve rea ch ed th e con s u m er m a rketp la ce. Exa m ples in clu de th e s ilicon a ccelerom eter in th e a u tom ot ive a n d video/ com pu ter ga m es in du s t r ies a n d th e Texa s In s t ru m en ts Digita l Mir ror Device for p roject ion d is p la ys . Yet , th is is on ly th e begin n in g. MEMS h a ve th e poten t ia l to p rovide cr it ica l en a b lin g s olu t ion s to m a n y n ew tech n ology a rea s in clu d in g wireles s com m u n ica t ion s , op t ica l com m u n ica t ion s a n d b iotech n ology. Exa m ples in clu de RF s witch es a n d oth er pa s s ive elem en ts for pers on a l com m u n ica t ion s ys tem s ; m icro-op t ica l s witch es for op t ica l fiber n etworks ; a n d ch em ica l "la b on a ch ip" for b iom edica l a pp lica t ion s . To fu r th er th is vis ion th e th ird Em ergin g In form a t ion Tech n ology Con feren ce is bein g orga n ized by a grou p of Ch in es e-Am er ica n p rofes s ion a ls a n d p rofes s ion a l orga n iza t ion s . Th e con feren ce wou ld be a foru m for th e la tes t developm en ts , is s u es , a n d t ren ds in MEMS in th e a rea s of 1 ) Con s u m er Produ cts (Au tom obile In du s t ry); 2 ) Wireles s Com m u n ica t ion s ; 3 ) Opt ica l Sys tem s ; 4 ) Biotech n olgoy; 5 ) Aeros pa ce Tech n ology, 6 ) Ha rs h En viron m en t In du s t r ia l Applica t ion s . MEMS h a ve rea ch ed a s ta ge for rea l a pp lica t ion s in m a n y fields . Exper ien ces a n d con s idera t ion s in p ra ct ica l fu n ct ion a l s ys tem s wou ld be welcom e. Th e ra p id growth a n d s u cces s of h igh tech n ology in du s t r ies a rou n d As ia h a ve t ra n s form ed m a n y econ om ies in clu d in g Ta iwa n ’s , wh ich h a s a th r ivin g s em icon du ctor a n d elect ron ics in du s t ry. Now, with th e m ovem en t of th e h igh -tech s ector in to in form a t ion tech n ology, a n d b iotech n ology, MEMS m a y h a ve a s ign ifica n t fu tu re role in th es e econ om ies . On e goa l of th is con feren ce is to bu ild a n d s t ren gth en tech n ica l a n d bu s in es s rela t ion s h ips a m on g profes s ion a ls , in s t itu t ion s a n d in du s t r ies a rou n d th e Pa cific Rim . Th e con feren ce wou ld p rovide a n oppor tu n ity for exper ts a n d in du s t ry lea ders to exch a n ge res ea rch developm en ts in MEMS tech n ologies , bu s in es s exper ien ces a n d to join t ly exp lore n ew d irect ion s a n d oppor tu n it ies .


5

System on Chip Workshop Dr iven by th e ra p id growth of th e In tern et , telecom m u n ica t ion s ys tem , wireles s tech n ology, perva s ive com pu t in g, con s u m er elect ron ics , a n d m u lt im edia a pp lica t ion s , th e in tegra t ion of a n en t ire VLSI s ys tem boa rd on to a s in gle s ilicon ch ip h a s becom e in crea s in gly im por ta n t in toda y’s n etworked wor ld . Th e p rolifera t ion of s ys tem -on -ch ip (SoC) devices is fu r th er eviden ced by th e u b iqu ity of cell ph on es , DVD p la yers , a n d d igita l ca m era s , wh ich b rou gh t revolu t ion a ry ch a n ges to th e IT in du s t ry. Th e s ys tem -on -ch ip t ra ck of EITC-2003 provides a foru m for s h a r in g recen t a dva n ces in s ys tem -on -ch ip des ign a n d d is cu s s in g n ew ch a llen ges in th e developm en t of SoC m a n u fa ctu r in g tech n ology, s ys tem in fra s t ru ctu re, des ign m eth odology, a n d des ign a u tom a t ion tools . It is ou r goa l to b r in g togeth er SoC exper ts from both th e a ca dem ics a n d in du s t ry to a ddres s th e cr it ica l h a rdwa re a n d s oftwa re des ign is s u es , s u ch a s power m a n a gem en t , s ign a l p roces s in g a n d s ecu r ity a pp lica t ion s , em bedded m em ory a n d proces s or cores , th e va lida t ion a n d reu s e of in tellectu a l p roper ty (IP), p la t form -ba s ed des ign with com m on a rch itectu res , a n d recon figu ra b le s ys tem s . Th e s u cces s fu l im plem en ta t ion a n d in tegra t ion of th es e key bu ild in g b locks will en a b le u s to develop im por ta n t SoC a pp lica t ion s in th e fu tu re with in crea s ed p rodu ct ivity a n d redu ced cos t .

Bioinformatics Workshop Th e wor ld is in th e m ids t of a n in form a t ion a n d com m u n ica t ion tech n ologica l revolu t ion th a t is t ra n s form in g a lm os t every a s pect of ou r lives . Th e in ters ect ion of in form a t ion tech n ology a n d b iotech n ology h a s becom e cr it ica lly im por ta n t beca u s e of th e va s t a m ou n t of da ta in volved in th e s tu dy of b iology. Bioin form a t ics is a n em ergin g d is cip lin e in th e com pu ta t ion a l s cien ces . It is very m u ch a d is cip lin e in expa n s ion a s eviden ced by th e con vergen ce of Biology, Com pu ter Scien ce, In form a t ion a n d Com m u n ica t ion Tech n ology, Ma th em a t ics a n d Sta t is t ics . Bioin form a t ics h igh ligh ts th e a pp lica t ion of s ta t is t ics , da ta m in in g, a r t ificia l in telligen ce, n eu ra l n etworks , m a ch in e lea rn in g a n d n a tu ra l la n gu a ge p roces s in g tech n iqu es to com pu ta t ion a lly d ifficu lt p rob lem s in m olecu la r b iology. It is ded ica ted to p rovide res ea rch ers th e kn owledge a n d s k ills n eces s a ry for th e in ven t ion of a lgor ith m s a n d th e crea t ion of com pu ta t ion a l s ys tem s th a t fa cilita te th e u n ders ta n d in g of b iologica l p roces s es a n d a pp lica t ion of th es e tools a n d m eth ods to in d ividu a ls a n d com m u n it ies th rou gh pu b lic h ea lth a n d preven t ion p rogra m s . Th e Hu m a n Gen om e Project h a s t ra n s form ed m olecu la r b iology in to a n in form a t ion -ba s ed s cien ce. However , th e la ck of a greem en t over th e n u m ber of h u m a n gen es , even with th e gen om e es s en t ia lly com plete, dep icts th e d ifficu lty of cer ta in ty in b iology a n d poin ts to th e n eed for s u bs ta n t ia lly bet ter a lgor ith m s a n d va lida t ion tech n iqu es . It is en vis a ged th a t b ioin form a t ics will h elp to a dva n ce b iom edica l res ea rch in s ilico. Th e b ioin form a t ics a pproa ch es to b iotech n ology h a ve b roa den ed th e con ven t ion a l a b ility to s tu dy gen om ics a n d proteom ics . Ph a rm a cogen om ics a n d ph a rm a cogen et ics a pproa ch es h a ve fu r th er a dva n ced dru g d is covery a n d dru g developm en t , a n d d is ea s e d ia gn os t ics device developm en t . In ves t iga t ion of th e rela t ion s h ip between in ter -in d ividu a l gen et ic va r ia b ility (polym orph is m ) in d ru g res pon s e (in clu d in g effica cy a n d s a fety) or d ru g m eta bolis m h a s m oved forwa rd th e p ra ct ice of m olecu la r b iology a n d th e view of th e fu tu re poten t ia l of m edicin e s u ch


6

a s in d ividu a lized m edicin e. An a logou s to h igh th rou gh pu t / da ta in ten s ive a n a lyt ica l m eth ods for gen om ic res ea rch , th e s in gle n u cleot ide polym orph is m (SNP) a r ra y tech n ology will r ely on th e b ioin form a t ics a n d s ta t is t ica l a lgor ith m s to p roper ly defin e SNP h a p lotypes s o a s to u n ders ta n d in d ividu a l p rofiles , wh ich en ta il in d ividu a l s u s cep t ib ility to d ru g toxicity a n d / or d ru g res pon s e. Bioin form a t ics Tra ck of EITC-2003 will be ded ica ted to ta lks from th e a ca dem ics a n d in du s t ry exper ts to a ddres s cr it ica l is s u es a n d s t im u la te idea s in a dd it ion to a ckn owledge it s recen t a dva n ces . It will en ga ge d ia logu es a cros s d is cip lin es a n d in vite d is cu s s ion s in th e forefron t of th e excit in g b iom edica l fron t ier .

Content, Computer, Communications, Consumer Electronics, and Integration (C4I) Workshop Adva n ces in com pu t in g a n d com m u n ica t ion s tech n ologies a re s ign ifica n t ly d r ivin g th e ch a n ge of everyon e’s life s tyle a n d th e t ra n s form a t ion of every orga n iza t ion ’s opera t ion s a n d bu s in es s m a n a gem en t p roces s es . Ma n y people n ow ca n n ot go ou t with ou t ca r ryin g a m obile ph on e. In a vera ge, peop le a re s pen d in g les s t im e in wa tch in g TV th a n u s in g th e Web brows er ch a t t in g with oth ers , com pos in g/ rep lyin g pers on a l em a il, s u r fin g/ s ea rch in g th e Web h yperm edia lib ra ry, bu yin g h a rd / s oft goods , p la yin g ga m es , etc. Orga n iza t ion s in th e wor ld a re expa n din g th e s cope of th eir IT ou ts ou rcin g from m a n a ged com pu t in g in fra s t ru ctu re (in clu d in g m a n a ged n etwork , s erver , a n d / or s tora ge) to bu s in es s p roces s m a n a gem en t . Big U.S. com pa n ies , in pa r t icu la r , a re s er iou s ly execu t in g offs h ore a n d n ea r -s h ore IT ou ts ou rcin g s t ra tegies to m a ke th em m ore com pet it ive in th e globa l m a rket . Th e C4I (Con ten t , Com pu ter , Com m u n ica t ion s , Con s u m er elect ron ics , a n d In tegra t ion ) works h op will b r in g togeth er in du s t ry lea ders a n d IT exper ts to s h a re th eir in s igh t fu l views of th e IT in du s t ry in th e era of on dem a n d com pu t in g, in wh ich IT res ou rces ca n be p rovis ion ed in a n on dem a n d fa s h ion a n d ca n be offered via a u s a ge-ba s ed p r icin g s ch em e. Th e works h op will ta ke a deep look a t th e ch a llen ges of exp loit in g a n d m a n a gin g th e com pu t in g en viron m en t in wh ich m illion s of orga n iza t ion s a n d b illion s of peop le a re con n ected by t r illion s of m edia -proces s in g devices . It will exa m in e h ow s ecu r ity a n d pr iva cy is s u es s h ou ld be a ddres s ed in th e des ign of a n IT s ys tem to fa cilita te ra p id a dopt ion of n ew tech n ologies on in form a t ion / kn owledge ca p tu r in g, a n a lys is , in tegra t ion , a n d d is s em in a t ion . Fin a lly, it will r eview em ergin g s ta n da rd-ba s ed n etwork com pu t in g a n d a pp lica t ion / proces s in tegra t ion tech n ologies s u ch a s Gr id , Web Services , etc.


7

In Memory of

Dr. Mo w -Shiah Lin

J uly 12, 1941 — September 12, 2003


8

Planning Committee

Conference Organizing Associations Ch in es e In s t itu te of En gin eers - U.S.A. Mon te J a de Scien ce a n d Tech n ology As s ocia t ion Ch in es e Am er ica n Aca dem ic a n d Profes s ion a l Society Ch in es e As s ocia t ion for Scien ce a n d Tech n ology, U.S.A.

Executive Secretary In ves tm en t a n d Tra de Office Ta ipei Econ om ic a n d Cu ltu ra l Repres en ta t ive Office in th e Un ited Sta tes

Conference Sponsors In ves tm en t & Tra de Office, TECRO Scien ce Divis ion , TECRO

Conference Planning Committee Conference Organizers

Su n -Yu a n Ku n g, Pr in ceton Un ivers ity Ts u -Ha n Ch en , Ca rn egie Mellon Un ivers ity

Conference Chairs

Ch in ta y Sh ih , In du s t r ia l Tech n ology Res ea rch In s t itu te Ru by Lee, Pr in ceton Un ivers ity

Program Chairs

Ch i-Ch a n g Ka o, Brookh a ven Na t ion a l La b Howa rd Ch en , IBM T. J . Wa ts on Res ea rch Cen ter Su e-J a n e Wa n g, Cen ter for Dru g Eva lu a t ion a n d Res ea rch , FDA Da rr in J . You n g, Ca s e Wes tern Res erve Un ivers ity Ron g Ch a n g, IBM T. J . Wa ts on Res ea rch Cen ter

Conference Coordinators

Fei Su n , Pr in ceton Un ivers ity Li-Sa n Wa n g, Un ivers ity of Pen n s ylva n ia

Conference Treasurer

J a s on Ch ou , Lu cen t Tech n ologies Program Committee

Clive E . Bowm a n , Gla xoSm ith Klin e Sa o-J ie Ch en , Na t ion a l Ta iwa n Un ivers ity Ben ja m in Ch u , S ta te Un ivers ity of New York a t S ton y Brook Ben ja m in S . Hs ia o, S ta te Un ivers ity of New York a t S ton y Brook Mich a el S . Hs ia o, Virgin ia Tech . Yu -Hen Hu , Un ivers ity of Wis con s in a t Ma dis on Su s a n Z. Hu a , S ta te Un ivers ity of New York a t Bu ffa lo


9

Ku a n -Ts a e Hu a n g, Ta s kco Corp . Wei Hwa n g, Na t ion a l Ch ia o-Tu n g Un ivers ity Ch en g-Ya n Ka o, Na t ion a l Ta iwa n Un ivers ity Howa rd F. Lee, Na n o Opto Lu ke P. Lee, Un ivers ity of Ca liforn ia a t Berkeley Si-Ch en Lee, Na t ion a l Ta iwa n Un ivers ity Sin g Lin , CSC Res ea rch LLC Sim on M. Lin , Du ke Un ivers ity Yih -Ka n g (Ma u r ice) Lin , AT&T La bs J u n g-Ta o Liu , Lu cen t Tech n ologies Zon -Yin Sh a e, IBM T.J . Wa ts on Res ea rch Cen ter Ch in g-Fa rn Wu , IBM T.J . Wa ts on Res ea rch Cen ter Th om a s D. Wu , Gen en tech In c. Mich elle Ya n , S iem en s Corpora te Res ea rch

Conference Manager Fei Su n , Pr in ceton Un ivers ity Local Management Wei-Hs in g Wa n g, Nich eUSA, L.L.C. Ch a n g Hon g Lin , Pr in ceton Un ivers ity Fund Raising

Pa u l Lin , AT&T La bs Ea -Ee J a n , IBM T. J . Wa ts on Res ea rch Cen ter J u n g-Ta o Liu , Lu cen t Tech n ologies Mich a el H. Wa n g, AT&T La bs

Publications/Proceedings

Wen n y Hs u , In ves tm en t & Tra de Office, TECRO Doreen Hu a n g, In ves tm en t & Tra de Office, TECRO Li-Sa n Wa n g, Un ivers ity of Pen n s ylva n ia Wei-Hs in g Wa n g, Nich eUSA, L.L.C.

Advance Registration

In ves tm en t & Tra de Office, TECRO On Site Registration

In ves tm en t & Tra de Office, TECRO Web Site

Elliot t Wu , Am er ica n Network Exper t Hotel/Local Accommodation Coordinator

Mich a el H. Wa n g, AT&T La bs Public Relations

Ch a o Agn es Hs iu n g, Na t ion a l Hea lth Res ea rch In s t itu tes Ch ih -Lin I, In du s t r ia l Tech n ology Res ea rch In s t itu te Wen Ko, Ca s e Wes tern Res erve Un ivers ity Spen cer P. Ku o, Polytech n ic Un ivers ity of New York Hen g-Ch u n Li, Mou n t Sin a i Sch ool of Medicin e Kevin Lu , Telcord ia Tech n ologies Stella Ku ei-An n Wen , Na t ion a l Ch ia o-Tu n g Un ivers ity


10

Members at Large Lia n g-Gee Ch en , Na t ion a l Ta iwa n Un ivers ity

Powen Hs u , Na t ion a l Ta iwa n Un ivers ity Ya rs u n Hs u , Na t ion a l Ts in g Hu a Un ivers ity Ton y A.-N. Kon g, Ru tgers Un ivers ity Sy-Yen Ku o, Na t ion a l Ta iwa n Un ivers ity Wei-Li Lee, Pr in ceton Un ivers ity Zh en g Li, Brookh a ven Na t ion a l La b Beth Lin, Brookhaven National Lab Ch ia J (Ch a r lie) Liu , AT&T La bs Yu n g S. Liu , In du s t r ia l Tech n ology Res ea rch In s t itu te Soo-Ch a n g Pei, Na t ion a l Ta iwa n Un ivers ity Hon g Sh i , Fa s h ion River Yu -Ch on g Ta i, Ca liforn ia In s t itu te of Tech n ology Norm a n Tien , Un ivers ity of Ca liforn ia a t Da vis Ch a n g-J ia Wa n g, Lu cen t Tech n ologies Li-Kon g Wa n g, Fu da n Un ivers ity H.S. Ph ilip Won g, IBM T. J . Wa ts on Res ea rch Cen ter Sta n is la u s Won g, Brookh a ven Na t ion a l La b Ch u n g-Yu (Peter ) Wu , Na t ion a l Ch ia o-Tu n g Un ivers ity Ch u a n -J ia n Zh on g, S ta te Un ivers ity of New York a t Bin gh a m ton Ru h on g Zh ou , IBM T. J . Wa ts on Res ea rch Cen ter

Honary Advisory Board

J ea n e Ch en , Kin tera In c. J en -Ya o Ch u n g, IBM T. J . Wa ts on Res ea rch Cen ter Ard in g Hs u , S iem en s Tech n ology-To-Bu s in es s Cen ter Sh in g-Fu Hs u eh , Wes t Win ds or Town s h ip , New J ers ey Hs in -Ku o Ka n , AT&T La bs J a y Ku o, Un ivers ity of Sou th ern Ca liforn ia Fern g-Ch in g Lin , In s t itu te for In form a t ion In du s t ry Ch u n g-Sh u Ya n g, AT&T La bs Hwa -Nien Yu , Aca dem ia Sin ica Ya -Qin Zh a n g, Micros oft Res ea rch As ia

Advisory Board

Chair: Sh ih -Fu Ch a n g, Colu m bia Un ivers ity Vic e Chair: Ch u n g-Sh en g Li, IBM T. J . Wa ts on Res ea rch Cen n ter Tre as ure r: Mich a el H. Wa n g, AT&T La bs Ch u n -Yen Ch a n g, Na t ion a l Ch ia o-Tu n g Un ivers ity Ron g Ch a n g, IBM T. J . Wa ts on Res ea rch Cen ter Ts u -Ha n Ch en , Ca rn egie Mellon Un ivers ity Wen -Ts u en Ch en , Na t ioa n l Ts in g Hu a Un ivers ity Ya w-Na n Ch en , Scien ce Divis ion , TECRO Wei Hwa n g, Na t ion a l Ch ia o-Tu n g Un ivers ity Su n -Yu a n Ku n g, Pr in ceton Un ivers ity Ru by Lee, Pr in ceton Un ivers ity Si-Ch en Lee, Na t ion a l Ta iwa n Un ivers ity Mow S. Lin , Brookh a ven Na t ion a l La b Sh ih -Pin g Liou , S iem en s Corpora te Res ea rch Lu rn g-Ku o Liu , IBM T. J . Wa ts on Res ea rch Cen ter Kevin Lu , Telcord ia Tech n ologies Ch in ta y Sh ih , In du s t r ia l Tech n ology Res ea rch In s t itu te J h in g-Fa Wa n g, Na t ion a l Ch en g Ku n g Un ivers ity Ca th y H. Wu , Georgetown Un ivers ity Medica l Cen ter Hen ry C. Ya n g, In ves tm en t & Tra de Office, TECRO


11

Website

h t tp :/ / www.eitc.org


12

Conference Program

Oc tobe r 3 1 , 2 0 0 3 (Friday) Nove m be r 1 , 2 0 0 3 (Saturday)

0 8 :0 0 AM to

0 9 :0 0 AM Re gis t rat ion Re gis t rat ion

0 9 :0 0 AM to

0 9 :5 0 AM Ope ning Re m arks Ope ning Re m arks

0 9 :5 0 AM to

1 0 :5 0 AM

P1 - Plen a ry Ses s ion I: Nanote c hnology

P3 - Plen a ry Ses s ion III: Sys te m -on-Chip

1 0 Minute s Bre ak Bre ak

1 1 :0 0 AM to

1 2 :2 0 PM

P2 – Plen a ry Ses s ion II: MEMS

P4 – Plen a ry Ses s ion IV: Bioinform at ic s

1 2 :3 0 PM to

0 2 :0 0 PM Lunc he on Lunc he on

T1 – Tech n ica l Ses s ion 1 : Nanote c hnology (I)

T11 – Tech n ica l Ses s ion 11 : Sys te m -on-Chip (III)

T2 – Tech n ica l Ses s ion 2 : MEMS (I)

T12 – Tech n ica l Ses s ion 12 : Bioinform at ic s (III)

T3 – Tech n ica l Ses s ion 3 : Sys te m -on-Chip (I)

T13 - Tech n ica l Ses s ion 13 : C4 I (III): Mult i-Se rvic e Com m unic at ions

T4 – Tech n ica l Ses s ion 4 : Bioinform at ic s (I)

T14 – Tech n ica l Ses s ion 14 : C4 I (IV): In form at ion and Knowle dge Manage m e nt

(Paralle l) 0 2 :0 0 PM

to 0 3 :4 5 PM

T5 – Tech n ica l Ses s ion 5 : C4 I (I): IT and Bus ine s s Proc e s s Outs ourc ing

3 0 Minute s Bre ak Bre ak

T6 – Tech n ica l Ses s ion 6 : Nanote c hnology (II)

T15 – Tech n ica l Ses s ion 15 : Sys te m -on-Chip (IV)

T7 – Tech n ica l Ses s ion 7 : MEMS (II)

T16 – Tech n ica l Ses s ion 16 : Bioinform at ic s (IV)

T8 – Tech n ica l Ses s ion 8 : Sys te m -on-Chip (II)

T17 – Tech n ica l Ses s ion 17 : C4 I (V) : Ubiquitous Com m unic at ions and Com put ing

T9 – Tech n ica l Ses s ion 9 : Bioinform at ic s (II)

T18 – Tech n ica l Ses s ion 18 : C4 I (VI): Hum an-Com pute r Inte grat ion

(Paralle l) 4 :1 5 PM

to 6 :0 0 PM

T10 – Tech n ica l Ses s ion 10 : C4 I (II): On De m and Com put ing Te c hnologie s


13

Day 1 (October 31, 2003) 0 8 :0 0 -0 9 :0 0 AM Re gis t rat ion 0 9 :0 0 -0 9 :5 0 AM Ope ning Re m arks Con feren ce Orga n izer : Su n -Yu a n Ku n g, Pr in ceton Un ivers ity Con feren ce Ch a ir : Ch in ta y Sh ih , In du s t r ia l Tech n ology Res ea rch In s t itu te (ITRI) Keyn ote Spea ker : “Tra n s it ion of IT In du s t ry in Ta iwa n ”

Ch in ta y Sh ih , In du s t r ia l Tech n ology Res ea rch In s t itu te (ITRI) 0 9 :5 0 -1 0 :5 0 AM P1 - Ple nary Se s s ion I: Nanote c hnology Ch a ir : Ch i-Ch a n g Ka o, Brookh a ven Na t ion a l La b “High Tem pera tu re Opera t ion (~240 K) of In As / Ga As a n d Silicon -Germ a n iu m Qu a n tu m Dot In fra red Ph otodetectors (QDIP)”

Si-Ch en Lee, Na t ion a l Ta iwa n Un ivers ity “DOE's Na n os ca le Scien ce Res ea rch Cen ters ”

Rober t Hwa n g, Brookh a ven Na t ion a l La b 1 0 :5 0 -1 1 :0 0 AM Bre ak 1 1 :0 0 AM-1 2 :2 0 PM P2 – Ple nary Se s s ion II: MEMS Ch a ir : Da r r in J . You n g, Ca s e Wes tern Res erve Un ivers ity “Na n o- a n d Micros ca le BioPOEMS”

Lu ke P. Lee, Un ivers ity of Ca liforn ia a t Berkeley “ In tegra t ion of a Micros ys tem for Ch em ica l a n d Biologica l Sen s in g”

Ch u n g-Ch iu n Liu , Ca s e Wes tern Res erve Un ivers ity “Opt ica l MEMS a t Micro a n d Na n o Sca le” Min g C. Wu , Un ivers ity of Ca liforn ia a t Los An geles 1 2 :3 0 -0 2 :0 0 PM Lunc he on 0 2 :0 0 -0 3 :4 5 PM Paralle l Te c hnic al Se s s ions T1 – Te c hnic al Se s s ion 1 : Nanote c hnology (I) Ch a irs : S i-Ch en Lee, Na t ion a l Ta iwa n Un ivers ity Howa rd F. Lee, Na n oOpto “Towa rds En a b lin g Ma ter ia ls Des ign for Low-Cos t Pla s t ic Tra n s is tors ”

Ben g On g, Xerox Res ea rch Cen t re of Ca n a da “Ma gn et ic Na n opa r t icle Arra ys for In form a t ion Tech n ology Applica t ion s ”

Sh ou h en g Su n , IBM T. J . Wa ts on Res ea rch Cen ter “Na n os ca le Fu n ct ion a liza t ion St ra tegies ”

S ta n is la u s Won g, Brookh a ven Na t ion a l La b J im Wa n g, Na n oOpto T2 – Te c hnic al Se s s ion 2 : MEMS (I) Ch a ir : Lu ke P. Lee, Un ivers ity of Ca liforn ia a t Berkeley “ In tegra t ion of MEMS a n d Pla n a r Wa vegu ide Tech n ologies for Ligh twa ve Switch in g”

Ho Bu n Ch a n , Lu cen t Tech n ologies “A Microm a ch in ed Tou ch -Mode Tu n a ble Ca pa citor for Wireles s Com m u n ica t ion s ”


14

Da rr in J . You n g, Ca s e Wes tern Res erve Un ivers ity “Developm en t of High Fill-fa ctor Microm ir ror Sca n n ers for Ada pt ive Opt ics ”

Veljko Mila n ovic, Adr ia t ic Res ea rch In s t itu te T3 – Te c hnic al Se s s ion 3 : Sys t e m -on-Chip (I) Ch a ir : Wei Hwa n g, Na t ion a l Ch ia o-Tu n g Un ivers ity “Som e Ch a llen ges for Low-Power Sys tem -On -a -Ch ip ”

Su h wa n Kim , IBM T. J . Wa ts on Res ea rch Cen ter “Power Ma n a gem en t for n a n o-CMOS Sys tem -on -Ch ip Des ign s : th e Prob lem , th e Tren d , a n d th e Solu t ion ”

Herm in g Ch iu eh a n d Wei Hwa n g, Na t ion a l Ch ia o-Tu n g Un ivers ity “CoMoC (Com m u n ica t ion on a Ch ip): A Sys tem a t ic Approa ch to Solve On -Ch ip Globa l Com m u n ica t ion Prob lem in SoC”

Yu -Hen Hu , Un ivers ity of Wis con s in a t Ma dis on “S i-Ba s ed RF SoC/ SoP For Wireles s Com m u n ica t ion ”

Ch ien -Na n Ku o a n d Yu -Tin g Ch en g, Na t ion a l Ch ia o-Tu n g Un ivers ity T4 – Te c hnic al Se s s ion 4 : Bio in form at ic s (I) Ch a ir : Ch en g-Ya n Ka o, Na t ion a l Ta iwa n Un ivers ity Room : 008 Th om a s Wu , Gen en tech Yin g Xu , Un ivers ity of Georgia “Dis ta n ce-Ba s ed Gen om e Rea r ra n gem en t Ph ylogen y”

Li-Sa n Wa n g, Un ivers ity of Pen n s ylva n ia “Ar ra yTra ck – Su ppor t in g Toxicogen om ic Res ea rch a t th e FDA’s Na t ion a l Cen ter for Toxicologica l Res ea rch (NCTR)”

Weida Ton g, NCTR, FDA T5 – Te c hnic al Se s s ion 5 (Pane l): C4 I (I): IT and Bus ine s s Proc e s s Outs ourc ing Ch a ir : Ku a n -Ts a e Hu a n g, Ta s kco Corp . Den g Ch ya n Ch en , In s t itu te for In form a t ion In du s t ry (III) Hs in -Ku o Ka n , AT&T La bs Ch in ta y Sh ih , In du s t r ia l Tech n ology Res ea rch In s t itu te (ITRI) Ko-Ya n g Wa n g, IBM Globa l Services Ch u n g-Sh u Ya n g, AT&T La bs 0 3 :4 5 -0 4 :1 5 PM Bre ak 0 4 :1 5 -0 6 :0 0 PM Paralle l Te c hnic al Se s s ions T6 – Te c hnic al Se s s ion 6 : Nanote c hnology (II) Ch a irs : Ben ja m in Ch u , Sta te Un ivers ity of New York a t S ton y Brook

Ben ja m in S . Hs ia o, S ta te Un ivers ity of New York a t S ton y Brook "Th e Abn orm a l Den s it ies of Poly(L-la ct ic) Acid a n d It s Im plica t ion on Pr im a ry Nu clea t ion "

J in g Wu , New J ers ey In s t itu te of Tech n ology "Self-As s em bly of a Novel As ym m etr ica l Bola a m ph iph ile: Acid ic Soph orolip id Molecu les "

Sh iqu in Zh ou , College of Sta ten Is la n d a n d th e Gra du a te Cen ter , th e City Un ivers ity of New York "Na n os t ru ctu red Ma ter ia ls for Adva n ced Sen s or Tech n ology"

Ch u a n -J ia n Zh on g, Sta te Un ivers ity of New York a t Bin gh a m ton "Crys ta lliza t ion in Na n o-Con fin em en t Cylin der a n d Dou ble Gyroid En viron m en ts "

Lei Zh u , th e Un ivers ity of Con n ect icu t


15

"New Na n opa r t icle Ca ta lys ts For Fu el Cells " J in Lu o, Sta te Un ivers ity of New York a t Bin gh a m ton

“Hiera rch ica l a s s em bly of a Ser ies of Rod-Coil Block Copolym ers : Su pra m olecu la r LC Ph a s e in Na n oen virom en t “

Ch r is toph er Y. Li, Drexel Un ivers ity T7 – Te c hnic al Se s s ion 7 : MEMS (II) Ch a ir : Su s a n Z. Hu a , S ta te Un ivers ity of New York a t Bu ffa lo “Ma gn et ic Colloids : From Na n os t ru ctu res to Com plex Sys tem s ”

Weili Lu o, Un ivers ity of Cen t ra l Flor ida “Des ign a n d Microfa br ica t ion of Bio-AFM Ca n t ilevers / Tips "

Xia oyu Ya n g, Nova s ca n Tech n ologies , In c “Sequ en t ia l E lect rolyt ic Bu bble-Ba s ed Micro-Pu m p”

Su s a n Z. Hu a , S ta te Un ivers ity of New York a t Bu ffa lo

T8 – Te c hnic al Se s s ion 8 : Sys t e m -on-Chip (II) Ch a ir : Yu -Hen Hu , Un ivers ity of Wis con s in a t Ma dis on “Ba s eba n d Sign a l Proces s in g IC for Wireles s Com m u n ica t ion Sys tem s ”

Tzi-Da r Ch iu eh , Na t ion a l Ta iwa n Un ivers ity "Ch a ra cter iza t ion of Logic Circu it Tech n iqu es for High Lea ka ge CMOS Tech n ologies "

Ph illip Ch in , Ch a r les Zu kows ki, Colu m bia Un ivers ity, a n d George Gr is tede, IBM T.J . Wa ts on Res ea rch Cen ter

“A Form a l Ver ifica t ion Pla t form for SoC” Pa o-An n Hs iu n g, Na t ion a l Ch u n g-Ch en g Un ivers ity

T9 – Te c hnic al Se s s ion 9 : Bio in form at ic s (II) Ch a ir : Th om a s D. Wu , Gen en tech In c. “Medica l Gen om ics a n d Gen om e Medicin e: a com pu ta t ion a l p ra ct ice

Sim on Lin , Du ke Un ivers ity “Norm a liza t ion for cDNA Microa r ra y Exper im en ts h a vin g m a n y Differen t ia lly Expres s ed Gen es ”

I-Sh ou Ch a n g, Na t ion a l Hea lth Res ea rch In s t itu tes (NHRI) Ben Hu i Liu , Bio-In form a t ics Grou p , In c Xia ole Liu , Ha rva rd Un ivers ity T1 0 – Te c hnic al Se s s ion 1 0 : C4 I (II): On De m and Com put ing Te c hnologie s Ch a ir : C. Er ic Wu , IBM T.J . Wa ts on Res ea rch Cen ter “ IBM On -Dem a n d Com pu t in g”

Ta n Lu , IBM On Dem a n d Sys tem s En viron m en t “Proa ct ive a n d Au ton om ic Com pu t in g: A Softwa re-en a b lin g Pla t form for th e En terpr is e”

An dy Lea n , Sequ oia Broa dba n d , In c. “On -Dem a n d Bu s in es s Colla bora t ion ”

Tia n Ch a o, IBM T.J . Wa ts on Res ea rch Cen ter "On -Dem a n d Bu s in es s Proces s Mon itor in g & Ma n a gem en t"

J u n -J a n g J en g, IBM T.J . Wa ts on Res ea rch Cen ter


16

Day 2 (November 1, 2003) 0 8 :0 0 -0 9 :0 0 AM Re gis t rat ion 0 9 :0 0 -0 9 :5 0 AM Ope ning Re m arks Con feren ce Orga n izer : Ts u -Ha n Ch en , Ca rn egie Mellon Un ivers ity Con feren ce Ch a ir : Ru by Lee, Pr in ceton Un ivers ity Keyn ote Spea ker : “Arch itectu re for Cyber Secu r ity”

Ru by Lee, Pr in ceton Un ivers ity 0 9 :5 0 -1 0 :5 0 AM P3 - Ple nary Se s s ion III: Sys t e m -on-Chip Ch a ir : Howa rd Ch en , IBM T. J . Wa ts on Res ea rch Cen ter Ts u -Ha n Ch en , Ca rn egie Mellon Un ivers ity “Sys tem -on -a -ch ip Syn th es is "

Nira j J h a , Pr in ceton Un ivers ity 1 0 :5 0 -1 1 :0 0 AM Bre ak 1 1 :0 0 AM-1 2 :2 0 PM P4 – Ple nary Se s s ion IV: Bio inform at ic s Ch a ir : Su e-J a n e Wa n g, Food a n d Dru g Adm in is t ra t ion “La rge-Sca le Ph ylogen et ic Recon s t ru ct ion ”

Ta n dy Wa rn ow, Un ivers ity of Pen n s ylva n ia “Bioin form a t ics a n d Pa t tern Dis covery a t IBM”

Da n Pla t t , IBM T. J . Wa ts on Res ea rch Cen ter “A Regu la tory Pers pect ive of Bioin form a t ics Da ta Gen era ted for Ph a rm a cogen om ics a n d Ph a rm a cogen et ics Stu d ies ”

Su e-J a n e Wa n g a n d La r ry Les ko, Food a n d Dru g Adm in is t ra t ion 1 2 :3 0 -2 :0 0 PM Lunc he on 0 2 :0 0 -0 3 :4 5 PM Paralle l Te c hnic al Se s s ions T1 1 – Te c hnic al Se s s ion 1 1 : Sys t e m -on-Chip (III) Ch a ir : Sa o-J ie Ch en , Na t ion a l Ta iwa n Un ivers ity “Overview of NTU SOC Cen ter ”

Sy-Yen Ku o, Na t ion a l Ta iwa n Un ivers ity "PowerHerd : A Dis t r ibu ted Sch em e for Dyn a m ica lly Sa t is fyin g Pea k Power Con s t ra in ts in In tercon n ect ion Networks "

Li Sh a n g, Pr in ceton Un ivers ity “Des ign a n d Im plem en ta t ion of a Pa ra llel Proces s or IC for J ob Sh op Sch edu lin g”

Ku a n -Hu n g Ch en , Tzi-Da r Ch iu eh , Sh i-Ch u n g Ch a n g, Na t ion a l Ta iwa n Un ivers ity, a n d Peter Lu h , Un ivers ity of Con n ect icu t T1 2 – Te c hnic al Se s s ion 1 2 : Bio inform at ic s (III) Ch a ir : Clive E . Bowm a n , Gla xoSm ith Klin e “ Im pa ct of Gen et ic HAP Ma rkers to Ou tcom es in Pros pect ive Clin ica l Tr ia ls ”

Ch u a n bo Xu , Gen a is s a n ce Ph a rm a ceu t ica ls , In c. “A Novel Wa y to Fin d th e Mos t Dis cr im in a n t Gen e Sets on Microa r ra y”

Ch en g-Ya n Ka o, Na t ion a l Ta iwa n Un ivers ity


17

“A Novel Pa t tern Recogn it ion for Microa r ra y Da ta An a lys is ” Hu ixia o Hon g, Bioin form a t ics La b ., NCTR, FDA

Kim Zerba , Br is tol-Myers Squ ibb In c. T1 3 - Te c hnic al Se s s ion 1 3 : C4 I (III): Mult i-Se rvic e Com m unic at ions Ch a ir : Yih -Ka n g (Ma u r ice) Lin , AT&T La bs “Network Con vergen ce”

Ma rga ret Ch ios i, AT&T La bs “Fu tu re Evolu t ion in Loca l Acces s Tech n ology a n d Teleph on y Services ”

Irwin Gers zberg, AT&T La bs “Au ton om ic Ma n a gem en t of Mu lt i-s ervice Com pu t in g Ut ilit ies ”

Lia n a Fon g, IBM T. J . Wa ts on Res ea rch Cen ter "Network ba s ed VPN Services – MPLS VPN"

Lu yu a n Fa n g, AT&T La bs T1 4 – Te c hnic al Se s s ion 1 4 : C4 I (IV): In form at ion and Knowle dge Manage m e nt Ch a ir : Zon -Yin Sh a e, IBM T.J . Wa ts on Res ea rch Cen ter “On Vis u a l S im ila r ity Ba s ed 3D Model Ret r ieva l” Min g Ou h you n g, Na t ion a l Ta iwa n Un ivers ity “E-Com m erce Va lu e Ch a in Bu s in es s Tra n s form a t ion ” J ih -Sh yr Yih , IBM T.J . Wa ts on Res ea rch Cen ter “From In form a t ion to Bu s in es s Proces s Ma n a gem en t ”

Sh ih -Pin g Liou , S iem en s Corpora te Res ea rch “Pr iva cy Protect ion on In form a t ion Ma n a gem en t ”

Xu a n Liu , IBM T.J . Wa ts on Res ea rch Cen ter 0 3 :4 5 -0 4 :1 5 PM Bre ak 0 4 :1 5 -0 6 :0 0 PM Paralle l Te c hnic al Se s s ions T1 5 – Te c hnic al Se s s ion 1 5 : Sys t e m -on-Chip (IV) Ch a ir : Mich a el S . Hs ia o, Virgin ia Tech . “Low-Com plexity/ High -Speed Forwa rd Er ror Cor rect ion Arch itectu re for Opt ica l Com m u n ica t ion s ”

Ha n h o Lee, Un ivers ity of Con n ect icu t “Tes t in g High -Frequ en cy Ser ia l Com m u n ica t ion In ter fa ces in th e SoCs ”

J ien -Ch u n g Lo, Un ivers ity of Rh ode Is la n d “Con s t ra in ed Tra n s it ion Fa u lt ATPG to Redu ce Yield Los s in SOCs ”

Xia o Liu a n d Mich a el S . Hs ia o, Virgin ia Tech . “Open Arch itectu re ATE: Softwa re Con s idera t ion s ”

Yu h a i Ma , Adva n tes t Am er ica , In c. T1 6 – Te c hnic al Se s s ion 1 6 : Bio inform at ic s (IV) Ch a ir : S im on M. Lin , Du ke Un ivers ity Ton y Kon g, Ru tgers , Th e Sta te Un ivers ity of New J ers ey “An In tegra ted Bioin form a t ics Approa ch for Proteom ic Expres s ion An a lys is of Clin ica l Sa m ples a n d It s Applica t ion to Biom a rker Dis covery “

Zh en Zh a n g, J oh n s Hopkin s Medica l In s t itu te “Un iMa rker a s a Fa s t Sequ en ce Ma ppin g a n d Gen om e Com pa r is on Meth od”

Min g-J in g Hwa n g, In s t itu te of Biom edica l Scien ces , Aca dem ia Sin ica “SNPs – from Tech n ology to Applica t ion ”

Clive, E . Bowm a n , Gla xoSm ith Klin e


18

T1 7 – Te c hnic al Se s s ion 1 7 : C4 I (V) : Ubiquitous Com m unic at ions and Com put ing Ch a irs : S in g Lin , CSC Res ea rch LLC

J u n g-Ta o Liu , Lu cen t Tech n ologies "Con vergen ce of Com m u n ica t ion s "

An wa r Sidd iqu i, Ava ya “Wi-Fi Ba s ed Pu blic Wireles s LAN”

Ma r t in Eis en s ch m eid , AT&T La bs “Perva s ive Com pu t in g Solu t ion s ”

Pa u l Ch ou , IBM T.J . Wa ts on Res ea rch Cen ter “Mobile Media a n d Hom e Network in g - Dr ivin g th e Con vergen ce of Com pu t in g a n d Com m u n ica t ion s ”

Hea th er Yu , Pa n a s on ic Res ea rch “Va r ia b le-Ph a s e-Sh ift -Ba s ed RF-Ba s eba n d Codes ign for MIMO An ten n a Select ion ”

Xin yin g Zh a n g, Pr in ceton Un ivers ity T1 8 – Te c hnic al Se s s ion 1 8 : C4 I (VI): Hum an-Com pute r Inte grat ion Ch a ir : Mich elle Ya n , Siem en s Corpora te Res ea rch “Wh a t is th e Next Big Th in g a fter Sea rch ?”

J a m es Sh a w, IBM T.J . Wa ts on Res ea rch Cen ter “Au gm en ted Rea lity a n d It s In du s t r ia l Applica t ion s ”

Zh a n g Xia n g, S iem en s Corpora te Res ea rch “Vir tu a lly Ph ys ica l Wh iteboa rds a n d In k In s ta n t Mes s a gin g”

Zon -Yin Sh a e, IBM T.J . Wa ts on Res ea rch Cen ter “Ma ch in e Recogn it ion of Hu m a n Fa ces ”

Wen -Yi Zh a o, Sa rn off


19

Abstracts and Biographies

Conference Organizers

Sun-Yuan Kung

Pr in ceton Un ivers ity

BIOGRAPHY

Su n -Yu a n Ku n g received h is Ph .D. Degree in Elect r ica l En gin eer in g from Sta n ford Un ivers ity. S in ce 1987 , h e h a s been a Profes s or of E lect r ica l En gin eer in g a t th e Pr in ceton Un ivers ity. In 1974 , h e wa s a n As s ocia te En gin eer of Am da h l Corpora t ion , Su n n yva le, CA. From 1977 to 1987 , h e wa s a Profes s or of E lect r ica l En gin eer in g-Sys tem s of th e Un ivers ity of Sou th ern Ca liforn ia , L.A. In 1984 , h e wa s a Vis it in g Profes s or of th e Sta n ford Un ivers ity a n d th e Delft Un ivers ity of Tech n ology. In 1994 h e wa s a Tos h iba Ch a ir Profes s or a t Wa s eda Un ivers ity, J a pa n , a n d a Hon ora ry Profes s or , Cen t ra l Ch in a Un ivers ity of Scien ce a n d Tech n ology, Ch in a . In 2001 , h e wa s a Dis t in gu is h ed Ch a ir of Mu lt im edia Sign a l Proces s in g, Hon g Kon g Polytech n ic Un ivers ity, Hon g Kon g. His res ea rch in teres ts in clu de VLSI a r ra y p roces s ors , im a ge/ video/ m u lt im edia s ign a l p roces s in g, n eu ra l n etworks for b iom etr ic a n d b ioin form a t ic s ign a l p roces s in g, a n d wireles s d igita l com m u n ica t ion . S in ce 1990 , h e h a s s erved a s a n Editor -In -Ch ief of J ou rn a l of VLSI Sign a l Proces s in g Sys tem s . He wa s a ppoin ted a s th e fir s t As s ocia te Ed itor in VLSI Area (1984) a n d th e fir s t As s ocia te Ed itor in Neu ra l Network (1991) of th e IEEE Tra n s a ct ion s on Sign a l Proces s in g. He s erved a s a m em ber of IEEE SPS (Sign a l Proces s in g Society) Adm in is t ra t ion Com m it tee (1989-1991). He wa s a fou n din g m em ber of IEEE-SPS Tech n ica l Com m it tees (TC) on VLSI Sign a l Proces s in g, TC on Neu ra l Networks , a n d TC on Mu lt im edia Sign a l Proces s in g. He s erved a s a fou n din g m em ber a n d Gen era l Ch a irm a n of va r iou s in tern a t ion a l con feren ces , in clu d in g IEEE Works h ops on VLSI Sign a l Proces s in g, IEEE Works h ops on Neu ra l Networks a n d Sign a l Proces s in g, IEEE Works h ops on Mu lt im edia Sign a l Proces s in g, In tern a t ion a l Con feren ce on Applica t ion Specific Arra y Proces s ors , a n d In tern a t ion a l Com pu ter Sym pos iu m . Profes s or Ku n g h a s a u th ored m ore th a n 300 tech n ica l pu b lica t ion s . He h a s a u th ored th ree books ‘‘VLSI Arra y Proces s ors ’’, (P-H, 1988) (with Ru s s ia n a n d Ch in es e t ra n s la t ion s ); ‘‘Digita l Neu ra l Networks ’’, P-H, 1993; a n d ‘‘Pr in cipa l Com pon en t Neu ra l Networks ’’, J oh n -Wiley, 1996 . He h a s ed ited n u m erou s referen ce books , in clu d in g: "VLSI a n d Modern Sign a l Proces s in g," Pren t ice-Ha ll, 1985 . (with Ru s s ia n t ra n s la t ion ), ‘‘VLSI Sign a l Proces s in g, Vol.I&II (IEEE Pres s ), ‘‘Neu ra l Networks for Sign a l Proces s in g, Vol. I,II & III (IEEE Pres s ), ‘‘Mu lt im edia Sign a l Proces s in g, Vol. I (IEEE Pres s ) a n d ‘‘Sys tolic Arra ys ’’, 1988 , ‘‘Applica t ion -Specific Arra y Proces s ors , (IEEE Com pu ter Society Pres s ). He h a s recen t ly co-ed ited a book on ‘‘Mu lt im edia Im a ge a n d Video Proces s in g’’, CRC Pres s , 2001 . Dr. Ku n g is a Fellow of IEEE s in ce 1988 . He wa s th e recip ien t of 1992 IEEE Sign a l Proces s in g Society’s Tech n ica l Ach ievem en t Awa rd for h is con t r ibu t ion s on "pa ra llel p roces s in g a n d n eu ra l n etwork a lgor ith m s for s ign a l p roces s in g". He wa s a ppoin ted a s a n IEEE-SP Dis t in gu is h ed Lectu rer in 1994 . He received 1996 IEEE Sign a l Proces s in g Society’s Bes t Pa per Awa rd for h is pu b lica t ion on p r in cipa l com pon en t n eu ra l n etworks . He wa s a recip ien t of th e IEEE Th ird Millen n iu m Meda l in 2000 .


20

Conference Organizers

Ts uhan Che n

Director , ITRI La b a t CMU Profes s or , E lect r ica l a n d Com pu ter En gin eer in g

Ca rn egie Mellon Un ivers ity Pit t s bu rgh , PA 15213 , USA

Tel: 412-268-7536 Fa x: 412-268-3890

Em a il: t s u h a n @cm u .edu

BIOGRAPHY Ts u h a n Ch en h a s been with th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g, Ca rn egie Mellon Un ivers ity, Pit t s bu rgh , Pen n s ylva n ia , s in ce October 1997 , wh ere h e is n ow a Profes s or . He d irects th e Adva n ced Mu lt im edia Proces s in g La bora tory, s t r ivin g to tu rn m u lt im edia tech n ologies from s cien ce fict ion in to rea lity. He a ls o es ta b lis h ed a n d is th e cu r ren t d irector of th e “ ITRI La b a t CMU,” a colla bora t ive res ea rch la bora tory s pon s ored by In du s t r ia l Tech n ology Res ea rch In s t itu te (ITRI), a t on e m illion dolla r s a yea r , with res ea rch focu s on Sys tem -on -Ch ip (SoC) a n d m u lt im edia / s ecu r ity a pp lica t ion s . His res ea rch in teres ts in clu de m u lt im edia s ign a l p roces s in g a n d com m u n ica t ion , im plem en ta t ion of m u lt im edia s ys tem s , m u lt im oda l b iom etr ics , a u d io-vis u a l in tera ct ion , pa t tern recogn it ion , com pu ter vis ion a n d com pu ter gra ph ics , b ioin form a t ics , a n d bu ild in g colla bora t ive vir tu a l en viron m en ts . From Au gu s t 1993 to October 1997 , h e worked in th e Vis u a l Com m u n ica t ion s Res ea rch Depa r tm en t , AT&T Bell La bora tor ies , Holm del, New J ers ey, a n d la ter a t AT&T La bs -Res ea rch , Red Ba n k , New J ers ey, a s a s en ior tech n ica l s ta ff m em ber a n d th en a p r in cip le tech n ica l s ta ff m em ber . Ts u h a n h elped crea te th e Tech n ica l Com m it tee on Mu lt im edia Sign a l Proces s in g, a s th e fou n din g ch a ir , a n d th e Mu lt im edia Sign a l Proces s in g Works h op , both in th e IEEE Sign a l Proces s in g Society. His en dea vor la ter evolved in to th e fou n din g of th e IEEE Tra n s a ct ion s on Mu lt im edia a n d th e IEEE In tern a t ion a l Con feren ce on Mu lt im edia a n d Expo, both join in g th e effor ts of m u lt ip le IEEE s ociet ies . He is a ppoin ted th e Editor -in -Ch ief for IEEE Tra n s a ct ion s on Mu lt im edia for 2002-2004 . Before s ervin g a s th e Editor -in -Ch ief for IEEE Tra n s a ct ion s on Mu lt im edia , h e a ls o s erved in th e Editor ia l Boa rd of IEEE Sign a l Proces s in g Ma ga zin e a n d a s As s ocia te Ed itor for IEEE Tra n s . on Circu it s a n d Sys tem s for Video Tech n ology, IEEE Tra n s . on Im a ge Proces s in g, IEEE Tra n s . on Sign a l Proces s in g, a n d IEEE Tra n s . on Mu lt im edia . He h a s co-ed ited a book t it led Adva n ces in Mu lt im edia : Sys tem s , S ta n da rds , a n d Networks . Ts u h a n received th e B.S. degree in elect r ica l en gin eer in g from th e Na t ion a l Ta iwa n Un ivers ity in 1987 , a n d th e M.S. a n d Ph .D. degrees in elect r ica l en gin eer in g from th e Ca liforn ia In s t itu te of Tech n ology, Pa s a den a , Ca liforn ia , in 1990 a n d 1993 , res pect ively. He received th e Ch a r les Wilt s Pr ize for ou ts ta n d in g in depen den t res ea rch in Elect r ica l En gin eer in g lea d in g to a Ph .D. degree a t th e Ca liforn ia In s t itu te of Tech n ology. He h a s pu b lis h ed m ore th a n a h u n dred of tech n ica l pa pers a n d h olds fifteen U.S. pa ten ts . He is a recip ien t of th e Na t ion a l Scien ce Fou n da t ion CAREER Awa rd , t it led “Mu lt im oda l a n d Mu lt im edia Sign a l Proces s in g,” from 2000 to 2003 .


21

Conference Chairs

Chintay Sh ih

In du s t r ia l Tech n ology Res ea rch In s t itu te Bldg.51 ,195 Sec.4 , Ch u n g Hs in g Rd . Ch u tu n g, Hs in ch u , Ta iwa n , ROC

Em a il: ct s h ih @it r i.org.tw

BIOGRAPHY

Educ at ion:

Ph .D. E lect r ica l En gin eer in g , Pr in ceton Un ivers ity 1975 M.S. Ma n a gem en t , S ta n ford Un ivers ity 1985 B.S. E lect r ica l En gin eer in g, Na t ion a l Ta iwa n Un iv. 1968 Expe rie nc e : Pres iden t of ITRI 1994 2003 Vice Pres iden t of ITRI 1989 1994 VP & Gen era l Director of ERSO/ ITRI 1984 1989 En gin eer Ma n a ger , Pla n t Ma n a ger of IC Cen ter , Depu ty

Gen era l Director of ERSO/ ITRI 1976 1984

Sen ior En gin eer , Bu r rou gh ts , USA 1974 1976 !Curre nt Pos it ion ! Specia l Advis or of ITRI 2003 !Re c e nt advis ory pos it ions :

!

Scien ce &Tech n ology Advis or of th e Execu t ive Yu a n s in ce 1998 Ch a irm a n of th e As ia Pa cific In tellectu ra l Proper ty As s ocia t ion s in ce 1997 Pres iden t of Ch in es e Bu s in es s In cu ba t ion As s ocia t ion s in ce 2003

!


22

Conference Chairs

Ruby Le e

Pr in ceton Un ivers ity BIOGRAPHY Profe s s or Ruby B. Le e is th e For res t G. Ha m rick Profes s or of En gin eer in g a n d Profes s or of E lect r ica l En gin eer in g a t Pr in ceton Un ivers ity, with a n a ffilia ted a ppoin tm en t in th e Com pu ter Scien ce depa r tm en t . Sh e is th e d irector of th e Pr in ceton Arch itectu re La bora tory for Mu lt im edia a n d Secu r ity (PALMS). Her cu r ren t res ea rch is in des ign in g s ecu r ity a rch itectu re a t both th e globa l GRID a rch itectu re level a n d th e core p roces s or a rch itectu re level. Sh e h a s a ls o des ign ed PLX, a very fa s t , t in y, m u lt im edia -ca pa b le p roces s or for in form a t ion a pp lia n ces , a n d h er s tu den ts a re con t in u in g to im prove th e PLX tes t -bed for p roces s or a rch itectu re res ea rch , edu ca t ion a n d a u tom a t ic s yn th es is . Her grou p exp lores th e des ign of s ecu r ity fea tu res th a t ca n be in tegra ted in to m icroproces s ors , a pp lica t ion -s pecific in s t ru ct ion p roces s ors (ASIPs ) a n d s ys tem -on -ch ips (SOCs ). Her res ea rch a ls o in clu des a rch itectu re for very h igh -per form a n ce m icroproces s ors a n d s u percom pu ters on a ch ip . Prof. Lee tea ch es a n u n dergra du a te cou rs e in “Cyber Secu r ity” a n d a gra du a te cou rs e in “Proces s or Arch itectu res for New Pa ra d igm s .” Pr ior to join in g th e Pr in ceton fa cu lty in 1998 , Dr . Lee s erved a s ch ief a rch itect a t Hewlet t -Pa cka rd , res pon s ib le a t d ifferen t t im es for p roces s or a rch itectu re, m u lt im edia a rch itectu re a n d s ecu r ity a rch itectu re for e-com m erce a n d exten ded en terpr is es . Sh e wa s a key a rch itect in th e in it ia l defin it ion a n d th e evolu t ion of th e PA-RISC proces s or a rch itectu re u s ed in HP s ervers a n d works ta t ion s . Sh e wa s th e tech n ica l lea d in th e fir s t CMOS PA-RISC m icroproces s or . As ch ief a rch itect for HP’s m u lt im edia a rch itectu re tea m , Dr . Lee led a n in ter -d is cip lin a ry tea m focu s ed on a rch itectu re to fa cilita te perva s ive m u lt im edia in form a t ion p roces s in g u s in g gen era l-pu rpos e com pu ters . Sh e p ion eered th e in t rodu ct ion of m u lt im edia in s t ru ct ion s in m icroproces s ors . Th is en a b led h er m u lt im edia tea m to p rodu ce th e in du s t ry’s fir s t r ea l-t im e, h igh fidelity, s t rea m in g MPEG video a n d a u d io p rodu ct im plem en ted en t irely in s oftwa re on low-en d com pu ters . Dr . Lee a ls o co-led a n In tel-HP m u lt im edia a rch itectu ra l tea m for IA-64 , recen t ly relea s ed in In tel’s Ita n iu m m icroproces s ors . Con cu r ren t with fu ll-t im e em ploym en t a t HP, Dr . Lee a ls o s erved a s Con s u lt in g Profes s or of E lect r ica l En gin eer in g a t S ta n ford Un ivers ity. Dr . Lee h a s a Ph .D. in Elect r ica l En gin eer in g a n d a M.S. in Com pu ter Scien ce a n d Com pu ter En gin eer in g, both from Sta n ford Un ivers ity, a n d a n A.B. with d is t in ct ion from Corn ell Un ivers ity, wh ere s h e wa s elected a College Sch ola r . Sh e is a Fellow of th e As s ocia t ion for Com pu t in g Ma ch in ery (ACM), a Fellow of th e In s t itu te for E lect r ica l a n d Elect ron ic En gin eers (IEEE), a n d a m em ber of Ph i Beta Ka ppa a n d Alph a La m bda Delta . Sh e h a s been gra n ted 115 U.S. a n d in tern a t ion a l pa ten ts , with s evera l pa ten t a pp lica t ion s pen d in g.


23

Conference Program Chairs

Dr. Chi-Chang Kao

Sen ior Scien t is t Brookh a ven Na t ion a l La bora tory

BIOGRAPHY Education Ph.D., Cornell University, Ithaca, N.Y., 1988 Experience Dr. Ka o’s res ea rch in teres t h a s been in th e developm en t of n ew exper im en ta l tech n iqu es u s in g s yn ch rot ron ra d ia t ion , a n d th eir a pp lica t ion s to con den s ed m a t ter ph ys ics a n d m a ter ia l s cien ce. In pa r t icu la r , h e h a s been work in g on th e developm en t of s oft -x-ra y res on a n t m a gn et ic s ca t ter in g for m a gn et is m a n d m a gn et ic m a ter ia l res ea rch , a n d h igh -res olu t ion in ela s t ic x-ra y s ca t ter in g for th e s tu dy of elect ron ic excita t ion s in con den s ed m a t ter s . Dr . Ka o join ed th e Na t ion a l Syn ch rot ron Ligh t Sou rce (NSLS) a t Brookh a ven Na t ion a l La bora tory (BNL) in 1988 a fter h e received h is Ph . D. Cu r ren t ly, h e is th e a s s ocia te ch a irm a n for u s er s cien ce a t th e NSLS, a n d is a ct ively in volved in th e BNL Cen ter for Fu n ct ion a l Na n om a ter ia ls (CFN). Dr . Ka o is a m em ber of th e Am er ica n Ph ys ica l Society a n d Am er ica n As s ocia t ion for th e Adva n cem en t of Scien ce. He h a s pu b lis h ed over 100 refereed pa pers , ch a ired a n d orga n ized m a n y s yn ch rot ron ra d ia t ion rela ted works h ops a n d m eet in gs , a n d s erved on m a n y n a t ion a l a n d in tern a t ion a l a dvis ory com m it tees .


24


Howard H. Che n

IBM Res ea rch Divis ion Th om a s J . Wa ts on Res ea rch Cen ter York town Heigh ts , New York , U.S.A.

BIOGRAPHY Dr . Howa rd Ch en received h is Ph .D. degree from th e Un ivers ity of Ca liforn ia , Berkeley, in 1987 . S in ce th en , h e h a s been with th e IBM Res ea rch Divis ion , Th om a s J . Wa ts on Res ea rch Cen ter , in York town Heigh ts , New York , wh ere h e is cu r ren t a res ea rch s ta ff m em ber . Dr . Ch en h a s received th e IBM In ven t ion Ach ievem en t Awa rd for 7 U.S. pa ten ts , th e IBM Res ea rch Divis ion Awa rd for con t r ibu t ion s to th e des ign a n d rea liza t ion of th e Allia n ce G4 m icroproces s or , th e IBM Ou ts ta n d in g Con tr ibu t ion Awa rd for th e des ign a n d rea liza t ion of th e Allia n ce G5 m icroproces s or , a n d th e IBM Res ea rch Divis ion Awa rd for th e des ign a n d im plem en ta t ion of Freewa y G7 m icroproces s or .


25


Sue -J ane Wang

Th e Sta t is t ics Repres en ta t ive FDA In ter -Cen ter Ph a rm a cogen om ics / Ph a rm a cogen et ics Work in g Grou p

U.S. Food a n d Dru g Adm in is t ra t ion Em a il: wa n gs @cder .fda .gov

Adju n ct Profes s or , J oh n s Hopkin s Un ivers ity, Pa r t -Tim e En gin eer in g Sch ool, Ma ryla n d

BIOGRAPHY

Su e-J a n e Wa n g h a s been s ervin g a s th e Sta t is t ics Repres en ta t ive of FDA in ter -cen ter (Cen ter for Dru g Eva lu a t ion a n d Res ea rch , Cen ter for Device a n d Ra diologica l Hea lth , Cen ter for Biologics Eva lu a t ion a n d Res ea rch a n d Na t ion a l Cen ter for Toxicology Res ea rch ) Ph a rm a cogen om ics / Ph a rm a cogen et ics (PG) Work in g Grou p . Her roles a re twofold . On e is to p rovide s pecific lea ders h ip in d is cu s s in g s ta t is t ica l con cep ts / is s u es of ph a rm a cogen om ics / ph a rm a cogen et ics s tu dy des ign a n d da ta a n a lys is in th e m u lt i-d is cip lin a ry exper t en viron m en t . A m a in ob ject ive of th e PG Work in g Grou p wa s to d ra ft a gu ida n ce for in du s t ry on Ph a rm a cogen et ics a n d Ph a rm a cogen om ics : Clin ica l S tu d ies a n d In Vitro Dia gn os t ic Tes ts in Ma rket in g Applica t ion s for Hu m a n Dru g Produ cts a n d Biologica ls . Th e s ta t is t ica l con s idera t ion s ect ion of th is d ra ft gu ida n ce for in du s t ry h a s in corpora ted gen era l p r in cip les in th e s ta t is t ica l review of gen e expres s ion s tu d ies a n d gen om e s ca n DNA s tu d ies in th e con text of n on clin ica l exper im en ts a n d clin ica l t r ia ls . As a m em ber of th e PG Work in g Grou p , Dr . Wa n g is cu r ren t ly in volved in p la n n in g th e s econ d PG works h op on “Ph a rm a cogen om ics in Dru g Developm en t a n d Regu la tory Decis ion -Ma kin g: Th e Gen om ic Da ta Su bm is s ion (GDS) Propos a l.” Th e in ten t of th e works h op is to p rovide a foru m for m ore deta iled d is cu s s ion of th e Agen cy’s p ropos a l a n d is s u es rela ted to defin in g volu n ta ry s u bm is s ion of PG da ta from ph a rm a ceu t ica l d ru g/ b iologics / device s pon s ors , th e form a t a n d proces s for p res en t in g s u ch da ta , a n d th e p rocedu re for regu la tory review. Sh e received h er m a s ter degree from Un ivers ity of Ca liforn ia , Los An geles , CA a n d Ph .D. from Un ivers ity of Sou th ern Ca liforn ia . Dr . Wa n g’s m a jor res ea rch a n d a pp lica t ion a ct ivit ies in clu de con t rolled clin ica l t r ia ls ; gen et ic a n d ep idem iologic s tu d ies ; s ta t is t ica l m eth ods for a n a lys is of m icroa r ra y da ta a n d ph a rm a cogen om ics / ph a rm a cogen et ics da ta in d ru g developm en t ; a n d tea ch in g in b ios ta t is t ics . Her p rofes s ion a l a ct ivit ies in clu de Editor -in -Ch ief: In tern a t ion a l Ch in es e Sta t is t ica l As s ocia t ion (ICSA) Bu llet in ; Sect ion Editor : Con trovers ia l S ta t is t ica l Is s u es ; Mem ber : th e Boa rd of Directors , Pu b lica t ion com m it tee a n d Awa rd com m it tee of ICSA; Ch a ir : s ta t is t ics s es s ion s a n d b iotech n ology s es s ion s in con feren ces , s ym pos iu m , works h ops in clu d in g Ph a rm a cogen om ics Ses s ion a n d Gen om ics in Dru g Dis covery a n d Developm en t Ses s ion a t th e FDA/ In du s t ry works h op , Sta t is t ics in Gen et ic Ep idem iology a t th e ICSA a pplied s ta t is t ics s ym pos iu m , Bio-Ch ip Tech n ology a n d Da ta Min in g s es s ion a t th e Sym pos iu m on Biom edica l Tech n ology Developm en t , etc. Dr . Wa n g received FDA Awa rd of Mer it s , FDA ou ts ta n d in g s ervice a wa rds , FDA/ CDER Excellen ce in com m u n ica t ion Awa rd , a n d FDA/ CDER Excellen ce in An a lyt ica l Scien ce Awa rd .


26


Darrin J . Young

Ca s e Wes tern Res erve Un ivers ity

BIOGRAPHY

Darrin J . Young r eceived h is BS, MS, a n d Ph D degrees from th e Depa r tm en t of E lect r ica l En gin eer in g a n d Com pu ter Scien ces a t Un ivers ity of Ca liforn ia a t Berkeley in 1991 , 1993 , a n d 1999 , res pect ively. His doctora l d is s er ta t ion em ph a s izes on m icroelect rom ech a n ica l devices des ign a n d fa br ica t ion tech n ologies for ra d io frequ en cy a n a log s ign a l p roces s in g. Between 1991 a n d 1993 , h e worked a t Hewlet t -Pa cka rd La bora tor ies in Pa lo Alto, Ca liforn ia , wh ere h e des ign ed a s h a red m em ory s ys tem for a DSP-ba s ed m u lt ip roces s or a rch itectu re. Du r in g th e s u m m er of 1997 , h e worked a t Rockwell Sem icon du ctor Sys tem s in Newpor t Bea ch , Ca liforn ia , wh ere h e des ign ed s ilicon b ipola r RF a n a log circu it s for cellu la r teleph on y a pp lica t ion s . Between 1997 a n d 1998 , h e wa s a ls o a t La wren ce Liverm ore Na t ion a l La bora tory, work in g on th e des ign a n d fa br ica t ion of th ree-d im en s ion a l RF coil in du ctors for wireles s com m u n ica t ion s . Dr . You n g join ed th e Depa r tm en t of E lect r ica l En gin eer in g a n d Com pu ter Scien ce a t Ca s e Wes tern Res erve Un ivers ity a s a n a s s is ta n t p rofes s or in 1999 . His m a in res ea rch in teres ts in clu de MEMS device des ign a n d fa br ica t ion , a n d in tegra ted a n a log circu it s des ign for wireles s com m u n ica t ion s , s en s in g, b iom edica l im pla n t , a n d gen era l in du s t r ia l a pp lica t ion s .


27


Dr. Rong Chang

Ma n a ger , Network Hos ted Applica t ion Services IBM T. J . Wa ts on Res ea rch Cen ter

19 Skylin e Dr ive, Ha wth orn e, NY 10532 , USA Tel: 1 -914-784-7850 , FAX: 1 -914-784-6205

Em a il: ron g@u s .ibm .com

BIOGRAPHY Dr . Ron g Ch a n g is Ma n a ger of Network Hos ted Applica t ion Services a t th e IBM T.J . Wa ts on Res ea rch Cen ter . He h a s received s evera l a wa rds a t IBM, in clu d in g a n Ou ts ta n d in g Tech n ica l Ach ievem en t Awa rd a n d a Tech n ica l Excellen ce Awa rd . He is a lea d in g con t r ibu tor to IBM’s (1 ) s ervice level a greem en t (SLA) m a n a gem en t com pon en t in IBM Ut ility Ma n a gem en t In fra s t ru ctu re, (2 ) rea l-t im e cred it ca rd p roces s in g a n d s oftwa re down loa d s ervice a t ibm .com , (3 ) com m on regis t ra t ion in fra s t ru ctu re for IBM’s In tern et Web s ites , (4 ) fir s t h yper lin k-a wa re s ea rch en gin e (n a m ed WebCa t), etc. His res ea rch in teres ts in clu de qu a lity-a s s u red on dem a n d s ervices , d is t r ibu ted com pu t in g s ys tem s , workflow-cen t r ic com pu t in g, h yperm edia in form a t ion m a n a gem en t , a n d pers on a l perva s ive com pu t in g a n d com m u n ica t ion . Dr . Ch a n g received th e B.S. degree with h on ors in com pu ter en gin eer in g from th e Na t ion a l Ch ia o Tu n g Un ivers ity, Ta iwa n , in 1982 , a n d th e Ph .D. degree in com pu ter s cien ce a n d en gin eer in g from th e Un ivers ity of Mich iga n , An n Arbor , in 1990 . From 1982 to 1984 h e s erved in th e Ch in es e Arm y Com m u n ica t ion s Sch ool, Ta iwa n , a s a n R&D s ta ff a n d a lectu rer in com pu ter s cien ce. From 1990 to 1993 , h e wa s Mem ber of Tech n ica l S ta ff in Bellcore's Applied Res ea rch Area develop in g ATM-ba s ed m u lt im edia com pu t in g & com m u n ica t ion s ervices a n d pers on a l m obile/ n om a dic/ perva s ive a pp lica t ion s ervices . Dr . Ch a n g is a m em ber of Ta u Beta Pi en gin eer in g h on or s ociety a n d Eta Ka ppa Nu elect ron ica l en gin eer in g h on or s ociety. He is a m em ber of ACM, IEEE, a n d Ch in es e In s t itu te of En gin eers ---USA.


28


Fe i Sun

E lect r ica l En gin eer in g Depa r tm en t Pr in ceton Un ivers ity

Em a il: fs u n @pr in ceton .edu

BIOGRAPHY Fei Su n received th e B.S. degree in Com pu ter Scien ce from Pek in g Un ivers ity, Beijin g, Ch in a in 2000 a n d th e M.A. degree in Elect r ica l En gin eer in g in 2002 from Pr in ceton Un ivers ity, Pr in ceton , NJ , USA, wh ere h e is cu r ren t ly pu rs u in g th e Ph .D. degree in Elect r ica l En gin eer in g. His res ea rch in teres ts in clu de a pp lica t ion s pecific in s t ru ct ion -s et p roces s or (ASIP) des ign , elect ron ic des ign a u tom a t ion (EDA) m eth odologies , low power des ign , h igh level s yn th es is , a n d h a rdwa re/ s oftwa re codes ign .


29


Li-San Wang

Depa r tm en t of Biology/ Cen ter for Bioin form a t ics / Abra m s on Ca n cer Cen ter Un ivers ity of Pen n s ylva n ia

Em a il: ls wa n g@m a il.m ed .u pen n .edu

BIOGRAPHY Li-Sa n Wa n g received h is B.S.E .E . (’94) a n d M.S.E .E . (’96) from th e Na t ion a l Ta iwa n Un ivers ity; h e th en received h is M.S. (’00) a n d Ph .D. (’03) from th e Un ivers ity of Texa s a t Au s t in , both in Com pu ter Scien ces . Cu r ren t ly h e is a pos tdoctora l fellow a t th e Un ivers ity of Pen n s ylva n ia . His res ea rch in teres t in clu des th eory of a lgor ith m s , ph ylogen et ics , a n d m icroa r ra y a n a lys es .


30

Day1

Keyn ote Speech

Chintay Sh ih

In du s t r ia l Tech n ology Res ea rch In s t itu te

Bldg.51 ,195 Sec.4 , Ch u n g Hs in g Rd . Ch u tu n g, Hs in ch u , Ta iwa n , ROC Tel: 886-3-5916212 Fa x: 886-3-5917213


ABSTRACT Th e IT in du s t ry in Ta iwa n is con fron ted with th e ch a llen ges of declin in g p rofit m a rgin , in crea s in g com pet it ion from Ma in la n d Ch in a , s h or ta ge of en gin eers a n d la ck of own bra n d n a m e. Mea n wh ile, we a ls o fin d s om e oppor tu n it ies from th e developm en t t ren d of th e in du s t r ia l globa liza t ion . Un der th e cos t down pres s u re, th e US in du s t r ies gra du a lly in crea s e ou ts ou rcin g for en gin eer in g a n d des ign . Th e en t ry to th e WTO of th e Cros s -s t ra it s m ea n s to open th e dom es t ic m a rket of Ma in la n d Ch in a will crea te bu s in es s oppor tu n it ies to Ta iwa n in du s t r ies . To en h a n ce p rodu ct va lu e a dded a n d s t ren gth com pet it iven es s , th e govern m en t of Ta iwa n s ets p la n s to es ta b lis h in n ova t ion a n d R&D cen ters in “ th e Na t ion a l Developm en t Pla n -Ch a llen ge 2008” to p rom ote key tech n ology res ea rch p rogra m s in b iotech , n a n otech , ch ip -s ys tem tech n ology, a n d b roa dba n d & wireles s com m u n ica t ion . To con clu de, we ca n s ee IT in du s t ry h a s bu ilt s olid fou n da t ion in Ta iwa n a fter deca des ’ developm en t . At th is m om en t , u n der th e d r ivin g force of in du s t ry globa liza t ion , Ta iwa n IT in du s t ry is t ra n s it in g from OEM or ien ted to va lu e a dded produ cts m a n u fa ctu r in g a n d s ys tem a pp lica t ion focu s in g on kn owledge-ba s ed s ervice. How to dep loy cu r ren t res ou rces a n d a dva n ta ges in IT in du s t ry to con t in u e th e in n ova t ion in tech n ology a n d to s t ren gth en com pet it iven es s is th e m os t im por ta n t is s u e to th e fu tu re in du s t ry developm en t in Ta iwa n .

BIOGRAPHY

Educ at ion:

Ph .D. E lect r ica l En gin eer in g , Pr in ceton Un ivers ity 1975 M.S. Ma n a gem en t , S ta n ford Un ivers ity 1985 B.S. E lect r ica l En gin eer in g, Na t ion a l Ta iwa n Un iv. 1968 Expe rie nc e : Pres iden t of ITRI 1994 2003 Vice Pres iden t of ITRI 1989 1994 VP & Gen era l Director of ERSO/ ITRI 1984 1989 En gin eer Ma n a ger , Pla n t Ma n a ger of IC Cen ter , Depu ty


Sen ior En gin eer , Bu r rou gh ts , USA 1974 1976 !Curre nt Pos it ion !


31

Specia l Advis or of ITRI 2003 !Re c e nt advis ory pos it ions :

!


!


32

P1 - Plen a ry Ses s ion 1 : Na n otech n ology

Ses s ion Ch a ir

Dr. Chi-Chang Kao

Sen ior Scien t is t Brookh a ven Na t ion a l La bora tory

BIOGRAPHY Education Ph.D., Cornell University, Ithaca, N.Y., 1988 Experience Dr. Ka o’s res ea rch in teres t h a s been in th e developm en t of n ew exper im en ta l tech n iqu es u s in g s yn ch rot ron ra d ia t ion , a n d th eir a pp lica t ion s to con den s ed m a t ter ph ys ics a n d m a ter ia l s cien ce. In pa r t icu la r , h e h a s been work in g on th e developm en t of s oft -x-ra y res on a n t m a gn et ic s ca t ter in g for m a gn et is m a n d m a gn et ic m a ter ia l res ea rch , a n d h igh -res olu t ion in ela s t ic x-ra y s ca t ter in g for th e s tu dy of elect ron ic excita t ion s in con den s ed m a t ter s . Dr . Ka o join ed th e Na t ion a l Syn ch rot ron Ligh t Sou rce (NSLS) a t Brookh a ven Na t ion a l La bora tory (BNL) in 1988 a fter h e received h is Ph . D. Cu r ren t ly, h e is th e a s s ocia te ch a irm a n for u s er s cien ce a t th e NSLS, a n d is a ct ively in volved in th e BNL Cen ter for Fu n ct ion a l Na n om a ter ia ls (CFN). Dr . Ka o is a m em ber of th e Am er ica n Ph ys ica l Society a n d Am er ica n As s ocia t ion for th e Adva n cem en t of Scien ce. He h a s pu b lis h ed over 100 refereed pa pers , ch a ired a n d orga n ized m a n y s yn ch rot ron ra d ia t ion rela ted works h ops a n d m eet in gs , a n d s erved on m a n y n a t ion a l a n d in tern a t ion a l a dvis ory com m it tees .


33


High Tem pera tu re Opera t ion (~240 K) of In As / Ga As a n d Silicon -Germ a n iu m Qu a n tu m Dot In fra red ph otodetectors (QDIP)

Si-Che n Le e

Depa r tm en t of E lect r ica l En gin eer in g a n d Gra du a te In s t itu te of E lect ron ic En gin eer in g, Na t ion a l Ta iwa n Un ivers ity,

Ta ipei, Ta iwa n , Repu blic of Ch in a

ABSTRACT Th ere a re two d ifferen t cla s s es of tech n iqu es to p rodu ce n a n opa r t icles . On e is ‘top-down ’ tech n iqu e a n d th e oth er is ‘bot tom -u p ’ p roces s . Th e ‘top-down ’ a pproa ch produ ce n a n opa r t icles from p la n a r growth a n d fa br ica t ion tech n iqu es in clu d in g e-bea m lith ogra ph y, pa t tern -depen den t oxida t ion (PADOX) m eth od , m olecu la r bea m ep ita xy (MBE) a n d s o on . Th e ‘bot tom -u p ’ a pproa ch s yn th es izes n a n opa r t icles from con s t itu en t a tom s in clu d in g ch em ica l p recip ita t ion , s ol-jel p roces s , th erm a l eva pora t ion , ch em ica l va por depos it ion (CVD), la s er a b la t ion , s pu t ter in g a n d s o on . In th is pa per , we u s e eith er top-down MBE to fa br ica te In As / Ga As qu a n tu m dot in fra red ph otodetector (QDIP), or com bin ed th e bot tom -u p , i.e., th e th erm a l eva pora t ion m eth od , a n d th e MBE to fa br ica te s ph er ica l s ilicon germ a n iu m (SiGe) QDIPs . Th e growth m ech a n is m of In As s elf-a s s em bly qu a n tu m dots on (001) Ga As by MBE h a d been s tu d ied in deta iled . It wa s fou n d th a t th e growth m ode ch a n ges a bru p t ly wh en th e depos it ion tem pera tu re in crea s es from 490°C to 510°C, i.e , th e dot s ize is u n iform ly d is t r ibu ted a t 490°C, bu t s witch es to two d is t in ct ly d ifferen t s ized grou ps a t 510°C. A n ew growth m ech a n is m is p ropos ed to exp la in th is ph en om en on . If a n In Ga As ca p la yer is depos ited on In As QDs before th e depos it ion of Ga As ba r r ier la yer , th e s t res s in du ced ph a s e s epa ra t ion growth of In As (on In As QD) a n d Ga As (on In As wet t in g la yer between QDs ) la yers wa s obs erved . Th e ph a s e s epa ra t ion growth lea ds to h igh qu a lity In As QDs with th icker ver t ica l s ize. Th e 10 s ta cked s elf-a s s em bled In As / Ga As qu a n tu m dot in fra red ph otodetector opera ted in 2 .5 to 7 �m ra n ge by ph otovolta ic a n d ph otocon du ct ive m ixed-m ode n ea r room tem pera tu re ( 250 K) wa s dem on s t ra ted . Th e s pecific pea k detect ivity D* is 2 .4 10 8 cm -Hz1/ 2 / W a t 250 K. Th e u s e of h igh -ba n dga p Al0.3Ga 0.7As ba r r ier s a t both s ides of th e In As qu a n tu m dot s t ru ctu re a n d th e lon g ca r r ier recom bin a t ion t im e a re th e key fa ctors res pon s ib le for it s n ea r -room -tem pera tu re opera t ion . A 600 n m boron doped Si(10 19/ cm 3) a n d th en 300 n m u n doped Si la yer wa s grown s equ en t ia lly on Si s u bs t ra te a t 600 by MBE. S iGe a lloy qu a n tu m dots were depos ited on th es e s a m ples by th erm a l eva pora t ion m eth od . After S iGe dots were depos ited , th is device wa s t rea ted by m eth a n ol. An u n doped la yer a n d boron doped Si la yer (10 19/ cm 3) were th en grown by MBE a t res pect ive 400 a n d 550 on top of SiGe dots . Th e pea k res pon s ivity of th e SiGe/ Si QDIP is 4 .2 m A/ W a t a wa velen gth region from 1 to 3 .5 m wh ich is s t ron ger th a n th e pea k res pon s ivity of 0 .67 m A/ W in th e region from 13 to 20 m . Th e h igh s pecific detect ivity (D*) a ch ieved is 5 .0 x 10 10 cm -Hz1/ 2/ W u n der zero b ia s . Th is QDIP is ca pa b le of opera t in g u p to a t 240 K with a good per form a n ce. BIOGRAPHY


34

Si-Che n Le e ( ) wa s born in Ta iwa n , on Au gu s t 13 , 1952 . He received th e B.S. degree in elect r ica l en gin eer in g from Na t ion a l Ta iwa n Un ivers ityin 1974 a n d Ph .D degree in elect r ica l en gin eer in g from Sta n ford Un ivers ityin 1980 with a work con s is t in g of exper im en ta l in ves t iga t ion of th e AlGa As / Ga As m u lt i-h eteroju n ct ion p roper t ies . From 1980 to 1982 , h e worked a t En ergy Con vers ion Devices In c. con cern in g th e a pp lica t ion of a m orph ou s s ilicon h ydrogen a lloy to th e s ola r cells . He join ed th e Depa r tm en t of E lect r ica l En gin eer in g, Na t ion a l Ta iwa n Un ivers ity in 1982 a s a vis it in g a s s ocia te p rofes s or , a n d is a p rofes s or n ow. He s erved a s th e ch a irm a n of th e Depa r tm en t from 1988 to 1992 a n d th e Dea n of a ca dem ic a ffa ir s of Na t ion a l Ta iwa n Un ivers ity from 1996 to 2002 . His cu r ren t res ea rch in teres ts a re in th e device a pp lica t ion s a n d th e growth k in et ics of In Ga As / Ga As s t ra in ed la yer qu a n tu m dot device, In Ga As / In As room tem pera tu re in fra red ligh t em it t in g d iode a n d ph otodetector with a pp lica t ion s to th e pollu t ion detect ion a n d b iologica l rea ct ion of cells . In a dd it ion , h e is a ls o in teres ted in h ydrogen a ted a n d deu tera ted a m orph ou s a n d poly-s ilicon (ca rbon , germ a n iu m ) h ydrogen m a ter ia l a n d devices , s u ch a s th in film t ra n s is tors a n d n eu ra l n etwork im a ge s en s ors . S in ce 1988 , h e p ion eered a res ea rch work on th e Ch in es e t ra d it ion a l qigon g a n d s om a t ic s cien ce wh ich con firm ed th e exis ten ce of cer ta in ext ra ord in a ry a b ility of h u m a n body, s u ch a s ch a ra cter recogn it ion by fin ger , ps ych okin es is . He a ls o d is covered th e exis ten ce of in form a t ion field (s p ir itu a l wor ld ) a n d p ropos ed th e “ u n ifica t ion of m in d a n d m a t ter ” to exp la in th e ph en om en a . Dr . Lee is a n IEEE Fellow, m em ber of th e Ch in es e In s t itu te of E lect r ica l En gin eer in g, h e h a s received Dr . Su n Ya t-Sa n Aca dem ic a wa rd in 1987 , five con s ecu t ive ou ts ta n d in g res ea rch a wa rds of Na t ion a l Scien ce Cou n cil from 1986 to 1996 . He h a s been elected a s a m em ber of Th e As ia -Pa cific Aca dem y of Ma ter ia ls (APAM) in 1997 , a n d received IEEE Th ird Millen n iu m Meda l for ou ts ta n d in g a ch ievem en ts a n d con t r ibu t ion s in th e a rea of Sem icon du ctor Devices in 2000 . In 2002 , h e wa s a wa rded th e Meda l of E lect r ica l En gin eer in g from th e As s ocia t ion of Ch in es e Elect r ica l En gin eer .


35


DOE’s Na n os ca le Scien ce Res ea rch Cen ters

Robe rt Hwang

Director , Cen ter for Fu n ct ion a l Na n om a ter ia ls Brookh a ven Na t ion a l La bora tory

Bu ild in g 555 Upton , NY 11973

h t tp :/ / www.cfn .bn l.gov/ Tel: 631 / 344-3322

Em a il: RHwa n g@bn l.gov

ABSTRACT As pa r t of th e Na t ion a l Na n otech n ology In it ia t ive, th e Office of Ba s ic En ergy Scien ces is con s t ru ct in g 5 Na n os ca le Scien ce Res ea rch Cen ters . In th is p res en ta t ion , I will des cr ibe th e m is s ion of th es e cen ters a n d h ow th e s cien t ific com m u n ity ca n in tera ct with th em .

BIOGRAPHY Rober t Q. Hwa n g is th e d irector of th e Brookh a ven Na t ion a l La bora tory Cen ter for Fu n ct ion a l Na n om a ter ia ls (CFN), wh ich is on e of 5 DOE Office of Scien ce s pon s ored Na n os ca le Scien ce Res ea rch Cen ter n a t ion a l u s er fa cilit ies . Pr ior to th is pos it ion , h e m a n a ged th e Th in Film a n d In ter fa ce Scien ce depa r tm en t a t Sa n d ia Na t ion a l La bora tor ies . He ea rn ed h is BS in ph ys ics from UCLA a n d h is Ph D from th e Un ivers ity of Ma ryla n d . He wa s a pos t -doc a t La wren ce Berkeley La b a n d UC Berkeley a n d a Hu m bold t Fellow a t th e Un ivers ity of Mu n ich . Bob’s in teres ts in clu de a tom is t ic m ech a n is m s in th in film growth a n d m eta l a lloyin g, th in film a n d in ter fa cia l s t ra in , cor ros ion a n d n a n o-s ca le p roper t ies of m eta ls .


36

P2 - Plen a ry Ses s ion 2 : MEMS

Ses s ion Ch a ir

Darrin J . Young

Ca s e Wes tern Res erve Un ivers ity

BIOGRAPHY Darrin J . Young r eceived h is BS, MS, a n d Ph D degrees from th e Depa r tm en t of E lect r ica l En gin eer in g a n d Com pu ter Scien ces a t Un ivers ity of Ca liforn ia a t Berkeley in 1991 , 1993 , a n d 1999 , res pect ively. His doctora l d is s er ta t ion em ph a s izes on m icroelect rom ech a n ica l devices des ign a n d fa br ica t ion tech n ologies for ra d io frequ en cy a n a log s ign a l p roces s in g. Between 1991 a n d 1993 , h e worked a t Hewlet t -Pa cka rd La bora tor ies in Pa lo Alto, Ca liforn ia , wh ere h e des ign ed a s h a red m em ory s ys tem for a DSP-ba s ed m u lt ip roces s or a rch itectu re. Du r in g th e s u m m er of 1997 , h e worked a t Rockwell Sem icon du ctor Sys tem s in Newpor t Bea ch , Ca liforn ia , wh ere h e des ign ed s ilicon b ipola r RF a n a log circu it s for cellu la r teleph on y a pp lica t ion s . Between 1997 a n d 1998 , h e wa s a ls o a t La wren ce Liverm ore Na t ion a l La bora tory, work in g on th e des ign a n d fa br ica t ion of th ree-d im en s ion a l RF coil in du ctors for wireles s com m u n ica t ion s . Dr . You n g join ed th e Depa r tm en t of E lect r ica l En gin eer in g a n d Com pu ter Scien ce a t Ca s e Wes tern Res erve Un ivers ity a s a n a s s is ta n t p rofes s or in 1999 . His m a in res ea rch in teres ts in clu de MEMS device des ign a n d fa br ica t ion , a n d in tegra ted a n a log circu it s des ign for wireles s com m u n ica t ion s , s en s in g, b iom edica l im pla n t , a n d gen era l in du s t r ia l a pp lica t ion s .


37


Na n o- a n d Micros ca le BioPOEMS*

Luke P. Le e

Berkeley Sen s or & Actu a tor Cen ter

Depa r tm en t of Bioen gin eer in g, UC Berkeley lp lee@s oca ra tes .berkeley.edu

ABSTRACT Th e BioPOEMS in ter fa ces b iologica l m olecu les or b iopolym ers with n a n os ca le p robes a n d b ioph oton ic m icros ys tem s . Th e BioPOEMS a llow to crea te a n ew pa ra d igm of la rge-s ca le h ybr id in tegra t ion of op t ica l, elect r ica l, a n d m icroflu id ic devices . Th e BioPOEMS ca n be exp loited in gen om ic/ proteom ic ch ips , poin t -of-ca re d ia gn os t ic b ioch ips , la b-on -a -ch ip , or a dva n ced im pla n ta b le devices . As exa m ples of m icros cale BioPOEMS , m icro-con foca l im a gin g a r ra y s ys tem (�CIAs ), d is pos a b le s elf-a lign ed in tegra ted m icroflu id ic op t ica l s ys tem s (SiMOS), a n d m icroa r ra ys of tota l in tern a l reflect ion flu ores cen t m icros copy (�TIRFM) on -a -ch ip a re developed for h igh -th rou gh pu t-s creen in g of cellu la r pa th wa y m on itor in g. For nanos cale BioPOEMS , n a n oflu id ic Su r fa ce-En h a n ced Ra m a n Spect ros copy (nSERS) a re bein g developed for s in gle b iom olecu la r detect ion b ioch ip a n d d irect DNA s equ en cin g. Ba tch fa br ica t ion of p la s m on -ba s ed n a n oph oton ic devices on t ra n s pa ren t s u bs t ra te with in tegra ted n a n oca vity ju n ct ion s is a ccom plis h ed for com pa ct a n d u lt ra s en s it ive b ioph oton ic n a n os ys tem s . In th is ta lk I will r eview th e ch a llen ges a n d a ch ievem en ts in th e h ybr id in tegra t ion of n a n oph oton ics a n d th e BioPOEMS for com pa ct , u lt ra s en s it ive, a n d a u ton om ou s s ys tem s . *BioPOEMS (Bio-Polym er-Opto-Elect ro-Microflu id ic-Sys tem ) BIOGRAPHY

Prof. Luke P. Le e is a n As s is ta n t Profes s or in th e Depa r tm en t of Bioen gin eer in g a t UC Berkeley, Co-Director of Berkeley Sen s or a n d Actu a tor Cen ter , a n d Director of Bion a n otech n ology Cen ter . He received both h is B.A. in Bioph ys ics a n d Ph .D. in Applied Scien ce & Tech n ology (m a jor : Applied Ph ys ics & m in or : Bioen gin eer in g) from UC Berkeley. His cu r ren t res ea rch top ics a re n a n o- a n d m icros ca le b ioph oton ic devices , BioMEMS, DNA n a n oelect ron ics , a n d m olecu la r b ioph ys ics .


38


In tegra t ion of a Micros ys tem for Ch em ica l a n d Biologica l Sen s in g

Chung-Chiun Liu

Depa r tm en t of En gin eer in g Ca s e Wes tern Res erve Un ivers ity

Clevela n d , Oh io 44106-7200 Tel: 216-368-2935 Fa x: 216-368-8738

Em a il: CXL9@cwru .edu

ABSTRACT A m icros ys tem for th e m on itor in g of a ch em ica l or b iologica l en viron m en t requ ires (1 ) m u lt ip le s en s ors or a n a r ra y of s en s in g elem en ts (2 ) a n in ter fa ce for th e t ra n s m is s ion of th e s en s or ou tpu ts to th e extern a l en viron m en t a n d (3 ) a s u ppor t in g en ergy s ou rce for th e opera t ion of th e s en s ors a n d th e in ter fa ce. In tegra t ion of th es e elem en ts in to a com plete m icros ys tem is th e ob ject ive of th is res ea rch . Pla t form tech n ology for va r iou s s en s or a r ra ys will be in t rodu ced . A wireles s m u lt i-ch a n n el telem etr ic in ter fa ce u s ed in th is res ea rch will be d is cu s s ed . Min ia tu re elect roch em ica l en ergy s ou rces , in clu d in g a m icro-fu el cell, por ta b le zin c-a lka lin e a n d zin c-a ir ba t ter ies a re u s ed a s th e s u ppor t in g en ergy s ou rces . S ilicon -ba s ed m icrofa br ica t ion a n d m icrom a ch in in g p roces s es a re th e u n derp in n in g tech n ica l a pproa ch es in th e developm en t of th e elem en ts a n d th e in tegra t ion of th e m icros ys tem . BIOGRAPHY Ch u n g-Ch iu n Liu is th e Wa lla ce R. Pers on s Profes s or of Sen s or Tech n ology a n d Con trol a n d a Profes s or of Ch em ica l En gin eer in g a t Ca s e Wes tern Res erve Un ivers ity. He is a ls o th e Director of th e Elect ron ics Des ign Cen ter , a m u lt i-d is cip lin a ry res ea rch a n d edu ca t ion a l Cen ter focu s in g on th e a pp lica t ion s of m icrofa br ica t ion tech n ology to th e developm en t of ch em ica l a n d b iologica l m icros ys tem s . His res ea rch in teres t in clu des m icrofa br ica t ion p roces s in g, ch em ica l a n d b iologica l s en s ors , a n d elect roch em ica l en ergy s ys tem s


39

T1 - Tech n ica l Ses s ion 1 : Na n otech n ology (I)

Ses s ion Ch a ir

Si-Che n Le e

Na t ion a l Ta iwa n Un ivers ity BIOGRAPHY Si-Che n Le e ( ) wa s born in Ta iwa n , on Au gu s t 13 , 1952 . He received th e B.S. degree in elect r ica l en gin eer in g from Na t ion a l Ta iwa n Un ivers ity in 1974 a n d Ph .D degree in elect r ica l en gin eer in g from Sta n ford Un ivers ityin 1980 with a work con s is t in g of exper im en ta l in ves t iga t ion of th e AlGa As / Ga As m u lt i-h eteroju n ct ion p roper t ies . From 1980 to 1982 , h e worked a t En ergy Con vers ion Devices In c. con cern in g th e a pp lica t ion of a m orph ou s s ilicon h ydrogen a lloy to th e s ola r cells . He join ed th e Depa r tm en t of E lect r ica l En gin eer in g, Na t ion a l Ta iwa n Un ivers ity in 1982 a s a vis it in g a s s ocia te p rofes s or , a n d is a p rofes s or n ow. He s erved a s th e ch a irm a n of th e Depa r tm en t from 1988 to 1992 a n d th e Dea n of a ca dem ic a ffa ir s of Na t ion a l Ta iwa n Un ivers ity from 1996 to 2002 . His cu r ren t res ea rch in teres ts a re in th e device a pp lica t ion s a n d th e growth k in et ics of In Ga As / Ga As s t ra in ed la yer qu a n tu m dot device, In Ga As / In As room tem pera tu re in fra red ligh t em it t in g d iode a n d ph otodetector with a pp lica t ion s to th e pollu t ion detect ion a n d b iologica l rea ct ion of cells . In a dd it ion , h e is a ls o in teres ted in h ydrogen a ted a n d deu tera ted a m orph ou s a n d poly-s ilicon (ca rbon , germ a n iu m ) h ydrogen m a ter ia l a n d devices , s u ch a s th in film t ra n s is tors a n d n eu ra l n etwork im a ge s en s ors . S in ce 1988 , h e p ion eered a res ea rch work on th e Ch in es e t ra d it ion a l qigon g a n d s om a t ic s cien ce wh ich con firm ed th e exis ten ce of cer ta in ext ra ord in a ry a b ility of h u m a n body, s u ch a s ch a ra cter recogn it ion by fin ger , ps ych okin es is . He a ls o d is covered th e exis ten ce of in form a t ion field (s p ir itu a l wor ld ) a n d p ropos ed th e “ u n ifica t ion of m in d a n d m a t ter ” to exp la in th e ph en om en a . Dr . Lee is a n IEEE Fellow, m em ber of th e Ch in es e In s t itu te of E lect r ica l En gin eer in g, h e h a s received Dr . Su n Ya t-Sa n Aca dem ic a wa rd in 1987 , five con s ecu t ive ou ts ta n d in g res ea rch a wa rds of Na t ion a l Scien ce Cou n cil from 1986 to 1996 . He h a s been elected a s a m em ber of Th e As ia -Pa cific Aca dem y of Ma ter ia ls (APAM) in 1997 , a n d received IEEE Th ird Millen n iu m Meda l for ou ts ta n d in g a ch ievem en ts a n d con t r ibu t ion s in th e a rea of Sem icon du ctor Devices in 2000 . In 2002 , h e wa s a wa rded th e Meda l of E lect r ica l En gin eer in g from th e As s ocia t ion of Ch in es e Elect r ica l En gin eer .


40


Ses s ion Ch a ir

Howard Le e

Na n oOpto

BIOGRAPHY HOWARD LEE is cu r ren t ly a m a n a gem en t con s u lta n t , boa rd m em ber a n d in ves tor in h igh -tech com pa n ies . He co-fou n ded Na n oOpto, a s ta r tu p th a t u s es Na n otech n olgy to fa br ica te pa s s ive in tegra ted op t ica l devices . He wa s th e fou n din g CEO of Na n oOpto a n d n ow s erves a s a boa rd m em ber . Previou s s ta r tu ps in clu de bein g th e in ter im CEO a n d boa rd m em ber of Equ a tor Tech n ology, a m edia p roces s or s ta r tu p in Silicon Va lley a n d th e Pres iden t of Ris e Tech n ology, a n In tel x86 com pa t ib le m icroproces s or s ta r tu p com pa n y. At Su n Micros ys tem s from 1984 to 1994 , h e wa s a vice p res iden t of en gin eer in g res pon s ib le for th e en gin eer in g a n d delivery of a ll Su n -2 a n d Su n -3 works ta t ion a n d s erver p rodu cts . He delivered th e Su n -4 Sever p rodu ct fa m ily a n d wa s in ch a rge of u n ifyin g a n d delivery of a ll SPARC m icroproces s or developm en t p rogra m s . Lee wa s th e s en ior vice p res iden t of th e Apple Ma cin tos h Divis ion res pon s ib le for th e en t ire ra n ge of com pu ter h a rdwa re a n d per iph era l p rodu cts with a n n u a l s a les of $9 Billion a n d u n it volu m e of 6 m illion Ma cs . Th es e in clu ded Ma cin tos h des k top , PowerBook , s erver , p r in ter , a n d d is p la y p rodu cts . His in du s t ry exper ien ce a ls o in clu des pos it ion s a t GRID Sys tem s , wh ere h e wa s m a n a ger for Ha rdwa re En gin eer in g, a n d m a n a gem en t pos ts a t Hewlet t -Pa cka rd in it s Pers on a l Office Com pu ter Divis ion a n d Hewlet t -Pa cka rd La bs . Lee h olds a ba ch elor ’s degree in elect r ica l en gin eer in g from Corn ell Un ivers ity, a m a s ter of en gin eer in g degree in elect r ica l en gin eer in g, a n d com pu ter s cien ce from th e Un ivers ity of Ca liforn ia , Berkeley, a n d a m a s ter ’s of bu s in es s a dm in is t ra t ion from th e Un ivers ity of Sa n ta Cla ra .


41


Towa rds En a b lin g Ma ter ia ls Des ign for Low-Cos t Pla s t ic Tra n s is tors

Be ng Ong

Fellow, Xerox In n ova t ion Grou p , Xerox Corpora t ion Ma n a ger , Xerox Res ea rch Cen t re of Ca n a da .

ABSTRACT Silicon in tegra ted circu it s (ICs ) a re won der fu l for h igh -en d m icroelect ron ics , bu t th ey m a y be u n ju s t ifia b ly or p roh ib it ively cos t ly for la rge-a rea devices (e.g., d is p la ys ) wh ere h igh s witch in g s peeds a re n ot requ ired . Orga n ic or p la s t ic th in film t ra n s is tors (TFTs ) a im to a ddres s th e h igh cos t is s u e of ICs by m ovin g th e m a n u fa ctu r in g from th e ca p ita l-in ten s ive, h igh tem pera tu re, h igh va cu u m com plex ph otolith ogra ph ic u lt ra -clea n room s etu p to a les s -con t rolled en viron m en t u s in g s olu t ion -ba s ed fa br ica t ion tech n ologies . To en a b le th is t ra n s it ion , m olecu la r ly en gin eered orga n ics , wh ich a re s olu t ion p roces s a b le a n d a re ca pa b le of s elf-orga n iza t ion in to p roper m icros t ru ctu res to p rovide fu n ct ion a lity, a re requ ired . Pr in ted ICs com pos ed of p la s t ic t ra n s is tors a re expected to be low cos t , a n d en a b le com pa ct , ligh tweigh t , a n d flexib le device des ign s , th u s u s h er in g in a n ew gen era t ion of s t ru ctu ra lly in s p ir in g elect ron ic p rodu cts . Th e is s u es , ch a llen ges a n d a dva n ces in m a ter ia ls des ign for th is em ergin g tech n ology will be p res en ted . Ou r p rogres s in develop in g s em icon du ctor polym ers with s u fficien t a ir s ta b ility to en a b le fa br ica t ion of h igh -per form a n ce p la s t ic t ra n s is tors u n der a m bien t con d it ion s will be des cr ibed . BIOGRAPHY Ben g On g received h is u n dergra du a te edu ca t ion in Sin ga pore, a n d com pleted h is Ph .D. s tu dy a t McGill Un ivers ity, Ca n a da . He join ed Xerox Res ea rch Cen t re of Ca n a da in 1978 a fter s pen d in g two yea rs a s a Res ea rch Fellow a t Ha rva rd Un ivers ity, Ca m br idge, MA. At Xerox, On g’s res ea rch h a s been wide ra n gin g, from elect ron ic m a ter ia ls for ph otorecep tors , s pecia lty ch em ica ls for ton ers a n d in ks to s ecu r ity a u th en t icity ta gga n ts , n ovel d is p la y con cep ts / m a ter ia ls , a n d p r in ted orga n ic elect ron ics . Ben g wa s th e key con t r ibu tor to Xerox’s recen t ly a n n ou n ced brea k th rou gh EA ton er tech n ology, develop in g a n d n u r tu r in g th is n ovel ch em ica l ton er con cep t from in fa n cy to m a tu r ity before s witch in g to s pea r -h ea d in g Xerox 21 s t-cen tu ry m a ter ia ls in it ia t ive in 2000 . He h olds s om e 115 U.S. pa ten ts in h is cred it , a n d is cu r ren t ly a Fellow of Xerox In n ova t ion Grou p , Xerox Corpora t ion , a n d Ma n a ger of Pr in ted Orga n ic Elect ron ics Res ea rch , Xerox Res ea rch Cen t re of Ca n a da .


42


Ma gn et ic n a n opa r t icle a r ra ys for in form a t ion tech n ology a pp lica t ion s

Shouhe ng Sun

Res ea rch Sta ff Mem ber , Na n os ca le Ma ter ia ls a n d Devices IBM T. J . Wa ts on Res ea rch Cen ter

Tel: 914-945-3762 Fa x: 914-945-2141

Em a il: s s u n @u s .ibm .com

ABSTRACT Ordered a r ra ys of m a gn et ic n a n opa r t icles a re p rom is in g ca n d ida tes for fu tu re in form a t ion tech n ology a pp lica t ion s . In th is ta lk , I will dem on s t ra te th a t m on odis pers e m a gn et ic n a n opa r t icles in clu d in g coba lt (Co), m a gn et ite (Fe3O4), a n d iron -p la t in u m (FePt) n a n opa r t icles , with con t rolled s ize, com pos it ion a n d s t ru ctu re ca n be rea d ily s yn th es ized by ch em ica l m eth ods , a n d s u bs equ en t ly in du ced to form 2-D a n d 3-D m a gn et ic n a n opa r t icle s u per la t t ice a r ra ys via s elf-a s s em bly. Th e in terpa r t icle s pa cin g in th e a r ra y ca n be a d ju s ted by eith er s u r fa ce ch em ica l liga n d exch a n ge or th erm a l t rea tm en t . Ma gn et ic p roper t ies of th es e a r ra ys ca n be tu n ed from s u perpa ra m a gn et ic to fer rom a gn et ic with con t rolled m a gn et ic m om en t . Fu r th er , th e h ydroph obic s u r fa cta n t la yer a rou n d ea ch n a n opa r t icle ca n be rep la ced with b ipola r s u r fa cta n ts , r en der in g th e pa r t icles h ydroph ilic a n d a b le to be d is pers ed in wa ter . Th es e well-en gin eered m a gn et ic n a n os t ru ctu res a re of grea t in teres t for deep u n ders ta n d in g of n a n om a gn et is m a n d will h a ve grea t poten t ia l in m a gn et ic n a n odevice a n d b io-m a gn et ic a pp lica t ion s . Severa l exa m ples of th e poten t ia l a pp lica t ion s of th es e s elf-a s s em bled n a n os t ru ctu res in in form a t ion da ta s tora ge, tu n n ellin g devices a n d perm a n en t m a gn et will be d is cu s s ed . BIOGRAPHY Sh ou h en g Su n is cu r ren t ly a res ea rch s ta ff m em ber in th e Ph ys ica l Scien ces Depa r tm en t a t th e IBM T. J . Wa ts on Res ea rch Cen ter . His cu r ren t res ea rch in teres t focu s on con t rolled s yn th es is of t ra n s it ion -m ea l-ba s ed n a n om a ter ia ls a n d s elf-a s s em bly of m on odis pers e m a gn et ic n a n opa r t icles in to fu n ct ion a l n a n odevices . Sh ou h en g Su n h olds a BS degree from Sich u a n Un ivers ity (Ch in a ), a n MS degree from Na n jin g Un ivers ity (Ch in a ) a n d a Ph D degree from Brown Un ivers ity (a ll in ch em is t ry). He wa s a n a s s is ta n t p rofes s or a n d a lectu rer in th e Depa r tm en t of Ch em is t ry a n d th e Coord in a t ion Ch em is t ry In s t itu te of Na n jin g Un ivers ity from 1987 to 1992 . He join ed IBM Res ea rch Divis ion a fter com plet in g h is doctora l s tu d ies in 1996 .


43


Na n os ca le Fu n ct ion a liza t ion St ra tegies

Sarbajit Bane rje e and Stan is laus S . Wong*

Depa r tm en t of Ch em is t ry; S ta te Un ivers ity of New York a t S ton y Brook; Ston y Brook , NY 11794; a n d Ma ter ia ls Scien ce Depa r tm en t , Brookh a ven Na t ion a l La bora tory; Bu ild in g 480 ; Upton , NY

11973 .

ABSTRACT Wh erea s th e ch em is t ry of fu lleren es is well-es ta b lis h ed , th e ch em is t ry of s in gle-wa lled ca rbon n a n otu bes (SWNTs ) is a rela t ively u n explored field of res ea rch . In ves t iga t ion s in to th e bon din g of m oiet ies on to SWNTs a re im por ta n t beca u s e th ey p rovide fu n da m en ta l s t ru ctu ra l in s igh t in to h ow n a n os ca le in tera ct ion s occu r . Hen ce, u n ders ta n d in g SWNT ch em is t ry becom es cr it ica l to ra t ion a l, p red ict ive m a n ipu la t ion of th eir p roper t ies . Am on g th e s t ra tegies d is cu s s ed in clu de m olecu la r m eta l com plexa t ion with SWNTs to con t rol s ite-s elect ive ch em is t ry in th es e s ys tem s . In pa r t icu la r , work h a s been per form ed u s in g Va s ka ’s a n d Wilk in s on ’s com plexes to crea te fu n ct ion a lized a ddu cts . Fu n ct ion a liza t ion s h ou ld offer a rela t ively s im ple m ea n s of tu be s olu b iliza t ion a n d bu n dle exfolia t ion a n d a llows for tu bes to be u t ilized a s recovera b le ca ta lys t s u ppor ts . To fu r th er dem on s t ra te ch em ica l p roces s a b ility of SWNTs , we h a ve s u b jected th em to ozon olys is , followed by t rea tm en t with va r iou s in depen den t rea gen ts , to ra t ion a lly gen era te a h igh er p ropor t ion of oxygen a ted fu n ct ion a l grou ps on th e n a n otu be s u r fa ce. Th is p rotocol h a s been fou n d to pu r ify n a n otu bes . More im por ta n t ly, th e rea ct ion s equ en ce h a s been fou n d to ozon ize th e s idewa lls of th es e n a n otu bes . Fin a lly, SWNTs h a ve a ls o been ch em ica lly m odified with qu a n tu m dots a n d oxide n a n ocrys ta ls . A com pos ite h eteros t ru ctu re con s is t in g of n a n otu bes join ed to n a n ocrys ta ls offers a u n iqu e oppor tu n ity to ob ta in des ired ph ys ica l, elect ron ic, a n d ch em ica l p roper t ies by a d ju s t in g s yn th et ic con d it ion s to ta ilor th e s ize a n d s t ru ctu re of th e in d ividu a l s u b-com pon en ts , with im plica t ion s for s elf-a s s em bly. BIOGRAPHY Profes s or Sta n is la u s S . Won g a n d h is grou p h a ve wide-ra n gin g in teres ts in th e s cien ce of n a n otech n ology. In a b roa d s en s e, h is grou p is fu n da m en ta lly in teres ted in s yn th es izin g, m a n ipu la t in g, a n d orga n izin g m a t ter in a con t rolla b le m a n n er a s well a s in p red ict in g a n d u n ders ta n d in g th e p roper t ies of th e res u lt in g s t ru ctu re a t th e n a n om eter s ca le. To a ccom plis h th is ob ject ive, th ey a re in ves t iga t in g th e ch em is t ry of a n d th e types of bon din g in n a n om a ter ia ls , s u ch a s ca rbon n a n otu bes . Som e of Dr . Won g’s a n d coworkers ’ r es u lt s h a ve been fea tu red in a cover a r t icle in Nature (1998) a n d in a n in vited Con cep ts a r t icle in Ch em is t ry: a Eu ropea n J ou rn a l (2003). Dr . Won g ea rn ed a B.Sc. (Fir s t Cla s s Hon ors ) from McGill Un ivers ity, received h is A.M. (1996) a n d Ph .D. (1999) degrees from Ha rva rd Un ivers ity (a dvis or : Ch a r les M. Lieber ), a n d com pleted a pos tdoctora l fellows h ip a t Colu m bia Un ivers ity (m en tor : Lou is E . Bru s ). S in ce Sep tem ber 2000 , h e h a s been a n As s is ta n t Profes s or in Ch em is t ry a t th e Sta te Un ivers ity of New York (SUNY) Ston y Brook with a join t a ppoin tm en t in th e Ma ter ia ls Scien ces Depa r tm en t a t Brookh a ven Na t ion a l La bora tory.


44

T2 - Tech n ica l Ses s ion 2 : MEMS (I)

Ses s ion Ch a ir

Luke P. Le e

Berkeley Sen s or & Actu a tor Cen ter Depa r tm en t of Bioen gin eer in g, UC Berkeley

lp lee@s oca ra tes .berkeley.edu

BIOGRAPHY Prof. Luke P. Le e is a n As s is ta n t Profes s or in th e Depa r tm en t of Bioen gin eer in g a t UC Berkeley, Co-Director of Berkeley Sen s or a n d Actu a tor Cen ter , a n d Director of Bion a n otech n ology Cen ter . He received both h is B.A. in Bioph ys ics a n d Ph .D. in Applied Scien ce & Tech n ology (m a jor : Applied Ph ys ics & m in or : Bioen gin eer in g) from UC Berkeley. His cu r ren t res ea rch top ics a re n a n o- a n d m icros ca le b ioph oton ic devices , BioMEMS, DNA n a n oelect ron ics , a n d m olecu la r b ioph ys ics .


45


In tegra t ion of MEMS a n d Pla n a r Wa vegu ide Tech n ologies for Ligh twa ve Switch in g

Ho Bun Chan a, D. T Fuc hs , H. R. Stuart , F. Baum ann, D. Gre ywall, M. E. Sim on

Bell La bs , Lu cen t Tech n ologies

aTel: 908-582-5038 Fa x: 908-582-6904

Em a il: h och a n @lu cen t .com

ABSTRACT Pla n a r wa vegu ide circu it s a re widely u s ed in telecom m u n ica t ion n etworks to per form a va r iety of op t ica l fu n ct ion s s u ch a s m u lt ip lexin g, s witch in g a n d a dd-drop . In th es e devices , s witch in g a n d recon figu ra t ion a re typ ica lly a ch ieved u s in g th e th erm o-op t ic effect . Th e power con s u m pt ion , th erm a l cros s -ta lk a n d s witch in g t im e of th erm o–opt ic s witch es ca n im pos e lim its on device per form a n ce. We dem on s t ra te th e in tegra t ion of p la n a r wa vegu ides a n d m icroelect rom ech a n ica l s ys tem s (MEMS). Ou r device con s is t s of a folded Ma ch Zeh n der in ter ferom eter in th e wa vegu ide pa r t a n d m ova ble p is ton m ir rors in th e MEMS pa r t . Th e MEMS m ir rors a re a ctu a ted elect ros ta t ica lly. Th ey provide a n a d ju s ta b le ph a s e s h ift in th e Ma ch Zeh n der in ter ferom eter to per form th e s witch in g fu n ct ion , with n egligib le d is s ipa t ion of power . Th e in s er t ion los s a n d ext in ct ion ra t io of th e device ra n ge from 13 .1 to 14 .7 dB a n d 11 to 21 .5 dB res pect ively. Th is tech n iqu e is a pp lica b le to oth er wa vegu ide devices wh ere ph a s e m a n ipu la t ion with low power con s u m pt ion is des ired . BIOGRAPHY Ho Bu n Ch a n is a m em ber of tech n ica l s ta ff in th e Micros ys tem s Res ea rch Depa r tm en t of Bell La bs , Lu cen t Tech n ologies in Mu rra y Hill, NJ . He ea rn ed h is BA degree in ph ys ics with h igh es t h on ors from Pr in ceton Un ivers ity in 1993 a n d Ph D degree in ph ys ics from MIT in 1999 . He join ed Bell la bs in 1999 a s a pos tdoctora l s ta ff. Dr . Ch a n ’s res ea rch focu s es on m icroelect rom ech a n ica l s ys tem s (MEMS) in fu n da m en ta l s cien ce a n d telecom m u n ica t ion n etworks . He per form ed th e fir s t dem on s t ra t ion of qu a n tu m m ech a n ica l Ca s im ir forces in MEMS, in th e regim e wh en s epa ra t ion between m icrom a ch in ed com pon en ts is redu ced to th e n a n om eter ra n ge. He is cu r ren t ly per form in g res ea rch in in tegra t in g MEMS with p la n a r wa vegu ides for en h a n ced fu n ct ion a lity a n d per form a n ce in m u lt i-wa velen gth op t ica l n etworks . He wa s a ls o in volved in th e developm en t a n d fa br ica t ion of MEMS opt ica l cros s con n ect for ligh t bea m s teer in g in op t ica l com m u n ica t ion n etworks .


46


A Microm a ch in ed Tou ch -Mode Tu n a ble Ca pa citor for Wireles s Com m u n ica t ion s

Darrin J . Young

EECS Depa r tm en t , Ca s e Wes tern Res erve Un ivers ity 10900 Eu clid Aven u e, Clevela n d , Oh io, 44106

ABSTRACT A m icrom a ch in ed tou ch -m ode tu n a b le ca pa citor is p ropos ed for wireles s com m u n ica t ion a pp lica t ion s . Th e tou ch -m ode a rch itectu re s u bs ta n t ia lly m in im izes th e device a rea a n d m icro-ph on ic effects . A fa br ica ted device a ch ieves a n om in a l ca pa cita n ce va lu e of 1 .86 pF with a tu n in g ra n ge of 25% u n der 5V a n d a qu a lity fa ctor of 22 a t 1 GHz a n d occu pies a circu la r a rea with a 140 � P�UDGLXV�� BIOGRAPHY Darrin J . Young r eceived h is BS, MS, a n d Ph D degrees from th e Depa r tm en t of E lect r ica l En gin eer in g a n d Com pu ter Scien ces a t Un ivers ity of Ca liforn ia a t Berkeley in 1991 , 1993 , a n d 1999 , res pect ively. His doctora l d is s er ta t ion em ph a s izes on m icroelect rom ech a n ica l devices des ign a n d fa br ica t ion tech n ologies for ra d io frequ en cy a n a log s ign a l p roces s in g. Between 1991 a n d 1993 , h e worked a t Hewlet t -Pa cka rd La bora tor ies in Pa lo Alto, Ca liforn ia , wh ere h e des ign ed a s h a red m em ory s ys tem for a DSP-ba s ed m u lt ip roces s or a rch itectu re. Du r in g th e s u m m er of 1997 , h e worked a t Rockwell Sem icon du ctor Sys tem s in Newpor t Bea ch , Ca liforn ia , wh ere h e des ign ed s ilicon b ipola r RF a n a log circu it s for cellu la r teleph on y a pp lica t ion s . Between 1997 a n d 1998 , h e wa s a ls o a t La wren ce Liverm ore Na t ion a l La bora tory, work in g on th e des ign a n d fa br ica t ion of th ree-d im en s ion a l RF coil in du ctors for wireles s com m u n ica t ion s . Dr . You n g join ed th e Depa r tm en t of E lect r ica l En gin eer in g a n d Com pu ter Scien ce a t Ca s e Wes tern Res erve Un ivers ity a s a n a s s is ta n t p rofes s or in 1999 . His m a in res ea rch in teres ts in clu de MEMS device des ign a n d fa br ica t ion , a n d in tegra ted a n a log circu it s des ign for wireles s com m u n ica t ion s , s en s in g, b iom edica l im pla n t , a n d gen era l in du s t r ia l a pp lica t ion s .


47


Developm en t of High Fill-fa ctor Microm ir ror Sca n n ers for Ada pt ive Opt ics

Dr. Ve ljko Milanovic , Gabe Matus , Dr. Danie l Mc Corm ic k

Adr ia t ic Res ea rch In s t itu te

ABSTRACT A m icrom a ch in ed tou ch -m ode tu n a b le ca pa citor is p ropos ed for wireles s com m u n ica t ion a pp lica t ion s . Th e tou ch -m ode a rch itectu re s u bs ta n t ia lly m in im izes th e device a rea a n d m icro-ph on ic effects . A fa br ica ted device a ch ieves a n om in a l ca pa cita n ce va lu e of 1 .86 pF with a tu n in g ra n ge of 25% u n der 5V a n d a qu a lity fa ctor of 22 a t 1 GHz a n d occu pies a circu la r a rea ZLWK�D�� P�UDGLXV�� BIOGRAPHY Dr . Veljko Mila n ovic - (M.Sc. a n d D.Sc. in E lect r ica l En gin eer in g - Microelect ron ics in 1996 a n d 1998 , Th e George Wa s h in gton Un ivers ity, Wa s h in gton , DC) fou n ded Adr ia t ic Res ea rch In s t itu te with a focu s on m icros ys tem s a n d n a n os ys tem s res ea rch a n d edu ca t ion for pu b lic ben efit . He is a ls o cu r ren t ly in volved in b iom olecu la r s cien ces res ea rch in th e Na n oen gin eer in g La bora tory a t th e Mech a n ica l En gin eer in g Depa r tm en t of UC Berkeley. Form er ly a pos t -doctora l res ea rch er a t th e Berkeley Sen s or a n d Actu a tor Cen ter , a n d a gu es t res ea rch er in th e Sem icon du ctor E lect ron ics Divis ion of th e Na t ion a l In s t itu te of Sta n da rds a n d Tech n ology, Veljko h a s been in volved in MEMS a n d n a n otech n ology res ea rch a n d developm en t effor ts for clos e to ten yea rs .


48

T3 - Tech n ica l Ses s ion 3 : Sys tem -on -Ch ip (SoC) (I)

Session Chair

Wei Hwang

National Chiao-Tung University BIOGRAPHY Dr . Wei Hwa n g is th e Director of Microelect ron ic a n d In form a t ion Sys tem s Res ea rch Cen ter a n d h olds th e NCTU Ch a ir Profes s or of E lect ron ics En gin eer in g a t Na t ion a l Ch ia o-Tu n g Un ivers ity in Hs in ch u , Ta iwa n s in ce Au gu s t 2002 . He is a ls o th e Director of Sys tem -on -Ch ip (SoC) Res ea rch Cen ter a t NCTU. Pr ior to th is , h e wa s a Res ea rch Sta ff Mem ber a t th e IBM Th om a s J . Wa ts on Res ea rch Cen ter , York town Heigh ts , NY from 1984 to 2002 . He a ls o s erved a s a n Adju n ct Profes s or of E lect r ica l En gin eer in g a t Colu m bia Un ivers ity in New York , NY from 1993 to 2003 . He wa s As s ocia te Profes s or of E lect r ica l En gin eer in g Depa r tm en t a t Colu m bia Un ivers ity in New York from 1979 to 1984 . He wa s As s is ta n t Profes s or of E lect r ica l En gin eer in g a t Con cord ia Un ivers ity in Mon trea l from 1975 to 1978 . He received h is M.S. a n d Ph .D. degrees from th e Un ivers ity of Ma n itoba in 1970 a n d 1974 res pect ively, h is M.S. degree from Na t ion a l Ch ia o-Tu n g Un ivers ity in 1967 , a n d h is B.S. degree from Na t ion a l Ch en g-Ku n g Un ivers ity in 1964 . Dr . Hwa n g’s in teres ts a re in th e gen era l a rea of VLSI circu it s a n d tech n ology, s em icon du ctor m em or ies , h igh -frequ en cy s erver m icroproces s ors , a n d em bedded s ys tem s . His cu r ren t res ea rch in teres ts a re in low-power SoC des ign a n d tech n ology, wireles s m obile com m u n ica t ion s a n d a pp lica t ion s . He h a s received s evera l IBM Awa rds , in clu d in g s ixteen IBM In ven t ion Pla tea u In ven t ion Ach ievem en t Awa rds , fou r IBM Res ea rch Divis ion Tech n ica l Awa rds , h a s been elected a n IBM Ma s ter In ven tor . Dr . Hwa n g is th e coa u th or of th e book "Elect r ica l Tra n s por ts in Solids ", wh ich h a s been t ra n s la ted in to Ru s s ia n a n d Ch in es e. He h a s a u th ored or coa u th ored over 110 tech n ica l pa pers in jou rn a ls a n d con feren ces , a n d h olds 122 in tern a t ion a l pa ten ts (in clu d in g 55 U.S. pa ten ts ). Dr . Hwa n g is a m em ber of th e New York Aca dem y of Scien ce, Ph i Ta u Ph i a n d Sigm a Xi. He is a ls o a n a ct ive m em ber of th e Ch in es e Am er ica n Aca dem ic a n d Profes s ion a l Society (CAAPS) wh ere h e h a s s erved s epa ra tely a s Pres iden t a n d Ch a irm a n of th e Boa rd . For h is lea ders h ip , h e received Cou rvois ier Lea ders h ip Awa rd in 1992 a n d th e CAAPS Specia l Service Awa rd in 1995 . Cu r ren t ly, h e s erves a s Co-Pr in cipa l In ves t iga tor of Na t ion a l Sys tem -on -Ch ip (SoC) Res ea rch Progra m of Na t ion a l Scien ce Cou n cil in Ta iwa n . Dr . Hwa n g is th e Ch a irm a n of IC in du s t ry com m it tee of Ch in es e In s t itu te of E lect r ica l En gin eer in g (CIEE) a n d a Fellow of th e In s t itu te of E lect r ica l a n d Elect ron ics En gin eers (IEEE)


49


Som e Ch a llen ges for Low-Power Sys tem -On -a -Ch ip

Suhwan Kim

IBM T. J . Wa ts on Res ea rch Cen ter York town Heigh ts , NY 10598

ABSTRACT New Proces s tech n ologies en a b le IC devices of ext rem e s izes a n d com plexity. Sys tem -On -a -Ch ip (SoC) des ign s in corpora te wh ole s ys tem on a s in gle ch ip . Yet a s com plexity in crea s e, in n ova t ive s olu t ion s a re requ ired to con s erve power . Recen t ly, th e dyn a m ic ch oices of power m a n a gem en t h a ve been s tu d ied , beca u s e n on -u n iform work loa ds du r in g th e opera t ion t im e a re com m on in com m u n ica t ion n etworks a n d in a lm os t a n y in tera ct ive s ys tem . Sin ce ea ch core or m a cro of th e em bedded s ys tem s m a y com e with d ifferen t power a n d per form a n ce ch a ra cter is t ics from a d ifferen t s ou rce, h owever , des ign in g a SoC th a t s u ppor ts dyn a m ic power m a n a gem en t is d ifficu lt a n d er ror -p ron e p roces s . In th is ta lk , fir s t of a ll, we’ll in ves t iga te key dyn a m ic power m a n a gem en t tech n iqu es , in term s of h igh -per form a n ce a n d low-power SoC des ign . It in clu des dyn a m ic s u pp ly volta ge a n d frequ en cy s ca lin g, a ct ive-well b ia s , power ga t in g, clock ga t in g, a n d m u lt ip le volta ge is la n ds . Th en , we’ll p res en t s om e oth er n ovel tech n iqu es s u ch a s s elf-b ia s power ga t in g s t ru ctu re a n d n on -a bru p t s leep t ra n s is tor s witch in g. BIOGRAPHY S uh w a n Kim r eceived th e B.S. a n d M.S. degrees in Elect r ica l En gin eer in g a n d Com pu ter Scien ce from Korea Un ivers ity, Korea , in 1990 a n d 1992 , res pect ively a n d th e Ph .D. degree in Elect r ica l En gin eer in g a n d Com pu ter Scien ce from th e Un ivers ity of Mich iga n , An n Arbor , in 2001 . From 1993 to 1997 , Dr . Kim wa s with LG Elect ron ics , Seou l Korea , wh ere h e des ign ed s evera l m u lt im edia s ys tem s -on -a -ch ip (SoC), in clu d in g a n MPEG2 CODEC for a u d io, video, a n d s ys tem . Dr . Kim join ed IBM Th om a s J . Wa ts on Res ea rch Cen ter in 2001 , wh ere h e cu r ren t ly is a Res ea rch Sta ff Mem ber (RSM). His res ea rch in teres ts en com pa s s circu it s a n d tech n ology for h igh -per form a n ce a n d low-power SoC a n d low-power des ign m eth odologies for h igh -per form a n ce VLSI s ign a l p roces s in g. Dr . Kim h a s received th e 1991 Bes t S tu den t Pa per Awa rd of th e IEEE Korea Sect ion a n d th e Fir s t Pr ize in th e VLSI Des ign Con tes t of th e 2001 ACM/ IEEE Des ign Au tom a t ion Con feren ce. Dr . Kim h a s a ls o received s evera l of a ch ievem en t a wa rds from LG Elect ron ics a n d IBM. He h a s pa r t icipa ted in th e Orga n izin g Com m it tee a n d Tech n ica l Progra m Com m it tee of th e IEEE In tern a t ion a l ASIC/ SOC Con feren ce a n d in th e Tech n ica l Com m it tee of th e In tern a t ion a l Sym pos iu m on Low Power Elect ron ics a n d Des ign s .


50


Power Ma n a gem en t for n a n o-CMOS Sys tem -on -Ch ip Des ign s : th e Prob lem , th e Tren d , a n d th e Solu t ion

He rm ing Chiue h and We i Hwang

SoC Res ea rch Cen ter

Na t ion a l Ch ia o Tu n g Un ivers ity Hs in ch u , Ta iwa n

ch iu eh @ieee.org, h wa n [email protected] ctu .edu .tw

ABSTRACT In crea s es in circu it den s ity a n d clock s peed in m odern s ys tem -on -ch ip (SoC) des ign s h a ve b rou gh t power is s u es in to th e s pot ligh t of h igh -s peed in tegra ted circu it des ign . Loca l overh ea t in g in on e s pot of a h igh -den s ity circu it ca n ca u s e a wh ole s ys tem to cra s h . Clock s yn ch ron iza t ion p rob lem s , pa ra m eter m is m a tch in g a n d oth er coefficien t ch a n ges du e to tem pera tu re gra d ien ts gen era ted by h igh power den s ity a n d u n even h ea t -u p of a ch ip a re on e of th e m a jor rea s on s for s ys tem fa ilu re. With th e in crea s in g s ize of in tegra ted circu it ry, th e tota l power of a typ ica l SoC des ign in crea s e d ra m a t ica lly, th a t es ca la tes th e p rob lem a n d s ys tem cos t by in t rodu cin g a com plica ted des ign in pa cka ge a n d s ys tem in tegra t ion . On th e oth er h a n d , a m odern m obile device ten ds to in tegra ted h eterogen eou s fu n ct ion a l b locks in to a ch ip : d ifferen t IP cores h a ve been in tegra ted in a p la t form -ba s ed SoC des ign flow to p rovide m ore fu n ct ion s . However , th e ba t tery power of s u ch a device is often lim ited . Th u s , power m a n a gem en t h a s becom e a key des ign is s u e in th e m odern low power a n d / or h igh per form a n ce SoC des ign s . Power a n d th erm a l p rob lem s in m odern SoC des ign s a re reviewed in th e begin n in g of th is pa per . Th en , th e t ren ds of both a ca dem ia a n d in du s t ry s olu t ion a re reviewed . At la s t , a th erm a l-a wa re power m a n a gem en t is p res en ted to m a n a ge th e power a n d loca l h ea t -u p on m odern SoC des ign s . Th e p ropos ed des ign ta rgets n om in a l power d is s ipa t ion a n d requ ires th e s ys tem to a ct ively m a n a ge it s power a n d th erm a l a ct ivit ies . Th e a rch itectu re will be en ca ps u la ted to a n IP (In tellectu a l Proper ty) m odu le or a vir tu a l com pon en t of th e m odern s ys tem -on -ch ip des ign flow, wh ich yields a s ys tem a t ic s olu t ion cros s in g th e a pp lica t ion / s ys tem / circu it / device la yers th a t will lin k u p th e a rch itectu re a n d cell circu it ry des ign a s well a s th e m odern n a n o-CMOS tech n ology s u ch a s volta ge is la n ds a n d m u lt i-th res h old t ra n s is tors to p rovide a com plete s olu t ion for SoC power m a n a gem en t . Sys tem a rch itects ca n u t ilize th is des ign to m on itor power a ct ivit ies a n d rea ct to s pecific con d it ion s th rou gh th e con t rollin g m ech a n is m , s u ch a s coolin g m ech a n is m a n d s ta te-m a ch in e ba s ed volta ge/ s peed / power m odu la t ion for d ifferen t m odu les of a n IP or a s ys tem , to en s u re th e power opera t ion a n d th erm a l beh a vior of a n SoC des ign work in g with in s pecifica t ion . By th e delica te power / s peed con t rollin g of d ifferen t m odu les on a n SoC s ys tem , th is des ign n ot on ly n om in a tes th e overa ll power con s u m pt ion , bu t a ls o m a xim izes th e per form a n ce of ta rget s ys tem in des ign ed power bu dget . Th e s u cces s of th is p roject offers a n oppor tu n ity for m odern SoC des ign s to in corpora te power m a n a gem en t tech n iqu es to en h a n ce s ys tem s ta b ility a n d per form a n ce. Th is des ign yields in t r ica te con t rol a n d op t im a l m a n a gem en t with lit t le s ys tem overh ea d a n d m in im u m h a rdwa re requ irem en ts , a s well a s p rovides th e flexib ility to s u ppor t d ifferen t m a n a gem en t a lgor ith m s .


51

Keywords : Sys tem -on -ch ip , VLSI, th erm a l m a n a gem en t , power m a n a gem en t , in tellectu a l p roper ty * Th is res ea rch is s u ppor ted by Na t ion a l Scien ce Cou n cil gra n t NSC-92-2218-E009-014 . BIOGRAPHY Dr . Herm in g Ch iu eh received h is B.S. degree from th e Depa r tm en t of E lect roph ys ics , Na t ion a l Ch ia o Tu n g Un ivers ity, Hs in -Ch u , Ta iwa n in 1992 , a n d th e M.S. a n d Ph .D. degrees from Depa r tm en t of E lect r ica l En gin eer in g, Un ivers ity of Sou th ern Ca liforn ia , Los An geles , U.S. in 1994 a n d 2002 . From 1996-2002 , h e wa s with In form a t ion Scien ces In s t itu te, Un ivers ity of Sou th ern Ca liforn ia , Ma r in a del Rey, Ca liforn ia , U.S. He is cu r ren t ly a n As s is ta n t Profes s or , Depa r tm en t of Com m u n ica t ion En gin eer in g, Sch ool of E lect r ica l En gin eer in g a n d Com pu ter Scien ce, Na t ion a l Ch ia o Tu n g Un ivers ity, Hs in -Ch u , Ta iwa n . His res ea rch in teres ts in clu de s ys tem -on -ch ip des ign m eth odology, th erm a l m a n a gem en t for VLSI, a n d power-a wa re in tegra ted circu it s .


52


CoMoC (Com m u n ica t ion on a Ch ip): A Sys tem a t ic Approa ch to Solve On -Ch ip Globa l Com m u n ica t ion Prob lem in SoC

Yu He n Hu, Charlie C.P. Che n*, and Lizhe ng Zhang

Un ivers ity of Wis con s in - Ma dis on

Dept . E lec & Com p. En gr . Ma dis on , WI 53706 , USA

h u @en gr .wis c.edu

*Na t ion a l Ta iwa n Un ivers ity In s t itu te of E lect ron ic En gin eer in g

Ta ipei, Ta iwa n , ROC

ABSTRACT Con t in u in g s h r in ka ge of fea tu re s ize a n d ever -in crea s in g SoC des ign com plexity p res en t grea t ch a llen ges to des ign h igh -relia b ility, h igh th rou gh pu t on -ch ip in tercon n ect ion circu it ry. Des ign u n cer ta in t ies r is e s h a rp ly du e to cou plin g n ois es , p roces s va r ia t ion s , a n d power delivery flu ctu a t ion s , a m on g m a n y oth er fa ctors dem a n d res ou rce-h u n gry s topga p m ea s u res , s u ch a s s h ield in g, bu ffer in s er t ion , s izin g, s pa cin g, a n d exten ded t im in g m a rgin s . Th es e rem edies , wh ile tem pora r ily m eet in g toda y’s dem a n d , do n ot offer a com preh en s ive, lon g term s olu t ion to th e m a n y on -ch ip com m u n ica t ion p rob lem s fa ced by th e n ext gen era t ion in tegra ted circu it . Th es e com m u n ica t ion ch a n n el im pa irm en t n ot on ly im pos e u n a ccep ta b le lim its on a t ta in a b le th rou gh pu t , bu t a ls o s er iou s ly com prom is e th e relia b ility of th e on -ch ip da ta com m u n ica t ion . To exp lore com preh en s ive, lon g-term s olu t ion s for SoC on -ch ip com m u n ica t ion s ys tem s , we en vis ion a h eterogen eou s , m u lt ip le-t iered on -ch ip in ter -com m u n ica t ion s ys tem th a t fa cilita tes h igh per form a n ce (h igh th rou gh pu t , low dela y, h igh relia b ility), cos t effect ive (low power con s u m pt ion , low a rea dem a n d) com m u n ica t ion s ervices to on -ch ip IPs . Specifica lly, we believe th a t th e on -ch ip in ter -con n ect ion com m u n ica t ion p rob lem m u s t be s olved a s a com m u n ica t ion s ys tem developm en t p rob lem . By ta k in g a s ys tem des ign a pproa ch , we will exp lore a com preh en s ive s olu t ion s pa ce, en com pa s s in g th eory, a lgor ith m a n d protocols , CAD tools , a rch itectu re. A prelim in a ry exp lora tory s tu dy of a wa ve-p ipelin ed globa l in tercon n ect ion m eth ods will a ls o be repor ted . BIOGRAPHY Yu Hen Hu is a fa cu lty m em ber a t th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g, Un ivers ity of Wis con s in , Ma dis on . He received BSEE from Na t ion a l Ta iwa n Un ivers ity, a n d MSEE a n d Ph D degrees from Un ivers ity of Sou th ern Ca liforn ia . Pr ior to join in g Un ivers ity of Wis con s in , h e wa s fa cu lty in th e Elect r ica l En gin eer in g Depa r tm en t of Sou th ern Meth odis t Un ivers ity, Da lla s , Texa s . His res ea rch in teres ts in clu de m u lt im edia s ign a l p roces s in g, a r t ificia l n eu ra l n etworks , fa s t a lgor ith m s a n d des ign m eth odology for a pp lica t ion s pecific m icro-a rch itectu res , a s well a s com pu ter a ided des ign tools . He h a s pu b lis h ed m ore th a n 180 tech n ica l pa pers in th es e a rea s . Dr . Hu is a fellow of IEEE. He is a form er a s s ocia te ed itor (1988-1990) for th e IEEE Tra n s a ct ion of Acou s t ic, Speech , a n d Sign a l Proces s in g in th e a rea s of s ys tem iden t ifica t ion a n d fa s t a lgor ith m s . He is cu r ren t ly a s s ocia te ed itor of IEEE Sign a l Proces s in g let ter s (2002-


53

2003), J ou rn a l of VLSI Sign a l Proces s in g, a n d Eu ropea n J ou rn a l of Applied Sign a l Proces s in g. He is a fou n din g m em ber of th e n eu ra l n etwork s ign a l p roces s in g tech n ica l com m it tee of IEEE s ign a l p roces s in g s ociety a n d s erved a s ch a ir from 1993-1996 . He is a form er m em ber of VLSI s ign a l p roces s in g tech n ica l com m it tee of th e s ign a l p roces s in g s ociety. He s erved a s th e s ecreta ry of th e IEEE s ign a l p roces s in g s ociety (1996-1998), a boa rd m em ber a t IEEE n eu ra l n etwork cou n cil, a n d is cu r ren t ly a s teer in g com m it tee m em ber of th e In tern a t ion con feren ce of Mu lt im edia a n d Expo on beh a lf of IEEE Sign a l p roces s in g s ociety.


54


S i-Ba s ed RF SoC/ SoP For Wireles s Com m u n ica t ion

Chie n-Nan Kuo and Yu-Ting Che ng

In n ova t ive Pa cka ge Res ea rch Cen ter Depa r tm en t of E lect ron ics En gin eer in g

Na t ion a l Ch ia o Tu n g Un ivers ity Hs in ch u , Ta iwa n

cn ku [email protected], ytch en g@m a il.n ctu .edu .tw

ABSTRACT

Silicon -ba s ed p la t form is p rovided a s th e ca n d ida te for th e in tegra t ion s olu t ion of wireles s com m u n ica t ion s ys tem s . Th e t ren d for Sys tem -on -Ch ip (SoC), in clu d in g co-des ign a n d fa br ica t ion of d igita l a n d a n a log pa r ts of a n en t ire s ys tem , ca lls for tech n ology developm en t on RF-SoC. As th e in ten t ion is fa cin g u n -res olva b le ch a llen gin g is s u es , s u ch a s low per form a n ce pa s s ive com pon en ts a n d power deficien t a m plifier fa br ica ted by s ta n da rd CMOS proces s , a n in term edia te a pproa ch is RF-SoC/ SiP tech n ology, wh ich a pp lies Low-Tem pera tu re Cofired-Cera m ics (LTCC) s u bs t ra te a s a n in tegra t ion ca r r ier with em bedded h igh -per form a n ce pa s s ives . Wh ile LTCC offers relief to th os e RF-SoC is s u es , s ilicon -ba s ed ca r r ier is s t ill p refer red a s fa r a s s ys tem in tegra t ion of m u lt i-fu n ct ion a l a n d h igh -per form a n ce ba s eba n d d igita l circu it ry is con cern ed . Th is a pproa ch , th erefore, is a im ed a t th e developm en t of in tegra t ion tech n ology a n d circu it for wireles s t ra n s ceiver des ign a s h igh ly in tegra ted h igh -per form a n ce m odu les , con s is t in g of a ct ive devices , pa s s ive com pon en ts a n d ch ip s ets , in th e tech n ology of s ilicon -ba s ed RF-SoC/ SoP. Keywords : Sys tem -on -Ch ip , Sys tem -on -Pa cka ge, h igh Q-fa ctor . * Th is res ea rch is s u ppor ted by Na t ion a l Scien ce Cou n cil gra n t NSC-92-2220-E-009-005 . BIOGRAPHY Chie n-Nan Kuo r eceived th e B. S . degree in elect ron ic en gin eer in g from Na t ion a l Ch ia o-Tu n g Un ivers ity, Hs in Ch u , Ta iwa n , in 1988 , th e M. S . degree in elect r ica l en gin eer in g from Na t ion a l Ta iwa n Un ivers ity, Ta ipei, Ta iwa n , in 1990 , a n d th e Ph . D. degree in elect r ica l en gin eer in g from th e Un ivers ity of Ca liforn ia , Los An geles (UCLA) in 1997 . He wa s with th e m obile s ys tem d ivis ion , ADC Telecom m u n ica t ion s a s a m em ber of th e tech n ica l s ta ff in Au g., 1997 . He join ed th e Com m u n ica t ion Res ea rch a n d Des ign Cen ter , IBM, for developm en t of RF s ys tem s a pp lica b le to WCDMA a n d CDMA2000 wireles s com m u n ica t ion s in 2000 . He is cu r ren t ly a n As s is ta n t Profes s or , Depa r tm en t of E lect ron ics En gin eer in g, Na t ion a l Ch ia o Tu n g Un ivers ity, Hs in -Ch u , Ta iwa n . His res ea rch in teres ts in clu de des ign a n d ch a ra cter iza t ion of RF a n d m icrowa ve a n d m illim eter -wa ve in tegra ted circu it s , th e s im u la t ion for th e elect r ic per form a n ce of elect ron ic pa cka gin g, a n d th e developm en t of elect rom a gn et ic s im u la t ion tools . Dr. Yu-Ting Che ng wa s born in Ta iwa n , Repu blic of Ch in a . He received h is B.S. a n d M.S. degree in Ma ter ia ls Scien ce a n d En gin eer in g, Na t ion a l Ts in g Hu a Un ivers ity, Hs in ch u , Ta iwa n in 1991 a n d 1993 , a n oth er M.S. degree in th e field a t Ca rn egie Mellon Un ivers ity, Pit t s bu rgh , PA, in 1996 , th en Ph .D. degree in Elect r ica l En gin eer in g a t th e Un ivers ity of Mich iga n , An n Arbor , in 2000 . His th es is is developm en t of a n ovel va cu u m pa cka gin g tech n iqu e for MEMS


55

a pplica t ion s . His res ea rch in teres ts in clu de th e fu n da m en ta l s tu dy of m a ter ia ls for MEMS a pplica t ion s , m icropa cka gin g, a n d n ew h ybr id m icrom a ch in in g fa br ica t ion of m icros t ru ctu res , m icros en s ors a n d m icroa ctu a tors . He join ed IBM Wa ts on Res ea rch Cen ter , York town Heigh ts , a s a res ea rch s ta ff m em ber a n d in volvin g in s evera l SOP (Sys tem on Pa cka gin g) p rojects in 2000 . He is cu r ren t ly a n As s is ta n t Profes s or , Depa r tm en t of E lect ron ics En gin eer in g, Na t ion a l Ch ia o Tu n g Un ivers ity, Hs in -Ch u , Ta iwa n . He is a m em ber of Ph i Ta u Ph i.


56

T4 - Tech n ica l Ses s ion 4 : Bioin form a t ics (I)

Ses s ion Ch a ir

Che ng-Yan Kao

Depa r tm en t of CSIE, Na t ion a l Ta iwa n Un ivers ity, Ta ipei 106 , Ta iwa n . cyka o@cs ie.n tu .edu .tw

BIOGRAPHY Ch en g-Ya n Ka o wa s born in Ta ipei, Ta iwa n , 1948 . He received B.S. in m a th em a t ics from Na t ion a l Ta iwa n Un ivers ity, Ta ipei, Ta iwa n , in 1971 , a n d th e M.S. degree in com pu ter s cien ce in 1976 , th e M.S. degree in s ta t is t ics in 1978 , a n d th e Ph .D. degree in com pu ter s cien ce in 1981 , a ll from th e Un ivers ity of Wis con s in -Ma dis on . He worked for Ford Aeros pa ce, th e Un is ys Corpora t ion , a n d worked for Gen era l E lect r ic from 1980 to 1989 a t th e J oh n s on Spa ce Cen ter , NASA, Hou s ton , TX. He h a s been a p rofes s or with th e Depa r tm en t of Com pu ter Scien ce a n d In form a t ion En gin eer in g, Na t ion a l Ta iwa n Un ivers ity s in ce 1990 . He h a s pu b lis h ed m ore th a n 40 tech n ica l pa pers in va r iou s jou rn a ls a n d in tern a t ion a l con feren ces . His res ea rch in teres ts in clu de b ioin form a t ics , b ioch ip , evolu t ion a ry com pu ta t ion , op t im iza t ion , a n d gr id com pu t in g. He h a s been th e p res iden t of Bioin form a t ics Society Ta iwa n s in ce 2000 .


57


Dis ta n ce-Ba s ed Gen om e Rea r ra n gem en t Ph ylogen y

Li-San Wang

Depa r tm en t of Biology/ Cen ter for Bioin form a t ics / Abra m s on Ca n cer Cen ter Un ivers ity of Pen n s ylva n ia

ABSTRACT Evolu t ion opera tes on wh ole gen om es th rou gh m u ta t ion s th a t ch a n ge th e order a n d s t ra n dedn es s of gen es with in th e gen om es . Th es e even ts a re exa m ples of ‘‘ra re gen om ic ch a n ges ,’’ wh ich h a ve low frequ en cy a n d h igh s ign a l-to-n ois e ra t io. Th u s a n a lys es of gen e-order da ta p res en t n ew oppor tu n it ies for d is cover ies a bou t deep evolu t ion a ry even ts , p rovided th a t s u fficien t ly a ccu ra te m eth ods ca n be developed to recon s t ru ct evolu t ion a ry t rees . In th is ta lk I will p res en t ou r res u lt s on d is ta n ce-ba s ed gen om e rea r ra n gem en t ph ylogen y recon s t ru ct ion . We a pproa ch th e p rob lem by develop in g n ew s ta t is t ica lly-ba s ed t ru e evolu t ion a ry d is ta n ce es t im a tors . In ou r s im u la t ion s tu dy, we ob ta in h igh ly a ccu ra te t rees by u s in g th es e n ew d is ta n ce es t im a tors , even wh en th e a m ou n t of evolu t ion in th e da ta s et is h igh . Fu r th erm ore, th es e n ew m eth ods grea t ly ou tper form previou s d is ta n ce-ba s ed a pproa ch es with res pect to topologica l a ccu ra cy. Th is is join t work with Rober t J a n s en a n d Ta n dy Wa rn ow (Un ivers ity of Texa s ) a n d Bern a rd Moret (Un ivers ity of New Mexico) wh ile th e p res en ter wa s a Ph .D. ca n d ida te a t th e Un ivers ity of Texa s . BIOGRAPHY Li-Sa n Wa n g received h is B.S.E .E . (’94) a n d M.S.E .E . (’96) from th e Na t ion a l Ta iwa n Un ivers ity; h e th en received h is M.S. (’00) a n d Ph .D. (’03) from th e Un ivers ity of Texa s a t Au s t in , both in Com pu ter Scien ces . Cu r ren t ly h e is a pos tdoctora l fellow a t th e Un ivers ity of Pen n s ylva n ia . His res ea rch in teres t in clu des th eory of a lgor ith m s , ph ylogen et ics , a n d m icroa r ra y a n a lys es .


58


Ar ra yTra ck – Su ppor t in g Toxicogen om ic Res ea rch a t th e FDA’s Na t ion a l Cen ter for Toxicologica l Res ea rch (NCTR)

We ida Tong

Director , Cen ter for Toxicoin form a t ics

Na ton a l Cen ter for Toxicologica l Res ea rch (NCTR), FDA Tel: 870-543-7142 Fa x: 870-543-7662

Em a il:wton g@n ctr .fda .gov

ABSTRACT Robu s t b ioin form a t ics ca pa b ility is widely a ckn owledged a s cen t ra l to rea lizin g th e p rom is es of m odern om ics tech n ologies . In tegra t in g om ics da ta with ph en otype p la ys a n es s en t ia l role in toxicogen om ics to s tu dy u n der lyin g m ech a n is m s of toxicology. At th e FDA’s Na t ion a l Cen ter for Toxicologica l Res ea rch (NCTR), we a re develop in g a pu b lic toxicoin form a t ics s ys tem to s u ppor t toxicogen om ics res ea rch . Th e s o-ca lled Toxicoin form a t ics In tegra ted Sys tem (TIS) in tegra tes gen om ic, p roteom ic a n d m eta bon om ic da ta with th e da ta from pu blic repos itor ies , a s well a s con ven t ion a l in vitro a n d in vivo toxicology da ta . Th is pa per p res en ts th e des ign , p ra ct ica l is s u es a n d fu n ct ion s of th e TIS for it s fir s t p rodu ct ion m odu le, Arra yTra ck th a t p rovides for m a n a gem en t a n d a n a lys is of DNA m icroa r ra y da ta . Arra yTra ck is logica lly con s t ru cted of th ree lin ked com pon en ts : 1 ) a da ta ba s e (Microa r ra yDB) th a t s tores m icroa r ra y exper im en ta l in form a t ion th a t is MIAME (Min im a l In form a t ion Abou t Microa r ra y Exper im en ts ) com plia n t ; 2 ) lib ra r ies (LIB) th a t m ir ror cr it ica l fu n ct ion a l da ta in pu b lic da ta ba s es ; a n d 3 ) tools (TOOL) th a t opera te on exper im en ta l a n d pu b lic da ta for kn owledge d is covery. Arra yTra ck en a b les da ta cu ra t ion in a ccorda n ce with s ta n da rd on tology a n d con t rolled voca bu la ry, fa cilita tes da ta in terpreta t ion a n d provides a n d in ter fa ces to a r ich collect ion of tools for da ta a n a lys is a n d kn owledge m in in g. Us in g Arra yTra ck , u s er ca n s elect a n a n a lys is m eth od from th e TOOL, a pp ly th e m eth od to s elected m icroa r ra y da ta s tored in th e Microa r ra yDB, a n d th e a n a lys is res u lt s ca n be d irect ly lin ked to gen e fu n ct ion s in th e LIB. Arra yTra ck is th e fir s t m odu le of th e TIS m a de pu b licly a va ila b le on lin e a n d from th e a u th ors u pon requ es t . BIOGRAPHY Dr . Ton g received h is Ph .D. in Polym er Ch em is t ry in 1990 , a n d wa s a res ea rch a s s ocia te in com pu ta t ion a l ch em is t ry for s ix yea rs a t th e Un ivers ity of Mis s ou r i-St . Lou is . In 1996 , h e join ed a n on -s ite IT con t ra ctor a t th e FDA’s NCTR, a n d h a s been work in g on en docr in e d is ru p t in g com pou n ds u s in g com pu ta t ion a l toxicology m eth ods a s well a s develop in g b ioin form a t ics a pproa ch es for gen om ics a n d proteom ics res ea rch . In J u n e of 2002 , h e join ed NCTR a s p rogra m Director of Cen ter for Toxicoin form a t ics . He is a ls o a n a d ju n ct p rofes s or in th e Depa r tm en t of Ph a rm a ceu t ica l Scien ces a t Un ivers ity of Arka n s a s for Medica l Scien ces .


59

T5 - Tech n ica l Ses s ion 5 : C4I (I): IT a n d Bu s in es s Proces s Ou ts ou rcin g

Ses s ion Ch a ir

Kuan-Ts ae Huang

Ch a irm a n & CEO Ta s kco Corpora t ion www.ta s kco.com .tw

Tel: 886-2-8772-2300 x151 Fa x: 886-2-8772-2301

Em a il: k th u a n g@ta s kco.com .tw

BIOGRAPHY Ku a n -Ts a e Hu a n g received th e B.S. degree in Ma th em a t ics from Na t ion a l Ta iwa n Norm a l Un ivers ity, Ta iwa n in 1974 , M.S. in Applied Ma th em a t ics from Un ivers ity of Illin ois -Urba n a Ch a m pa ign in 1979 , a n d Ph .D. in Elect r ica l En gin eer in g a n d Com pu ter Scien ce from MIT in 1982 . Dr . Hu a n g is cu r ren t ly th e Ch a irm a n & CEO of Ta s kco Corpora t ion , a com pa n y focu s in g on e-Bu s in es s a n d Kn owledge Ma n a gem en t Con s u lt in g a n d Solu t ion Services . Merr ill Lyn ch h a d ra ted Ta s kco a s on e of th e key As ia ’s lea d in g e-Bu s in es s com pa n y. Ta s kco’s core bu s in es s is to h elp com pa n y t ra n s form in to kn owledge s ervice opera t ion with bu s in es s p roces s re-en gin eer in g a n d e-Bu s in es s / KM s olu t ion s . Cu r ren t ly, Ta s kco is th e CIO Progra m Ma n a gem en t office for Ta iwa n ’s e-Govern m en t In it ia t ive. In a dd it ion , Dr . Hu a n g is on th e boa rd of BioGen om ix, a lea d in g b iotech n ology com pa n y, a n d wa s th e Ch a irm a n of Yu en -Ta i VC firm (a s s ocia ted with Yu en -Da s ecu r ity firm in Ta iwa n ). Dr . Hu a n g wa s on e of th e p ion eers in th e Offs h ore Ou ts ou rcin g bu s in es s to Sin ga pore & In d ia ba s ed in Sin ga pore s in ce 1989 . Recen t ly, He wa s in vited to a Ch in a ’s five city tou r on IT Ou ts ou rcin g by UNDEV fu n d a t J a n u a ry of 2003 . Dr . Hu a n g join ed IBM Wa ts on Res ea rch Cen ter in 1982 a s pa r t of QBE/ OBE Da ta ba s e tea m a n d la ter h old s evera l m a n a gem en t pos it ion s with in IBM Res ea rch a n d Globa l Services . Du r in g h is As ia a s s ign m en t from 1989 , He wa s GM of Mu lt im edia Bu s in es s Un it of IBM As ia Pa cific a n d CEO of a n IBM J V com pa n y, Sin ga La b . From 1995 , He wa s a Director a t IBM Globa l Services lea d in g th e effor t of As s et Reu s e a n d Kn owledge Ma n a gem en t to h elp t ra n s form IBM in to a globa l s ervice bu s in es s . S in ce 1998 , h e wa s th e IBM Vice Pres iden t to lea d th e wor ldwide e-Bu s in es s im plem en ta t ion a n d Web a pp lica t ion la bora tory for IBM’s Corpora te t ra n s form a t ion . He h a d won th e Gold m eda l of Giga In form a t ion Awa rd on BPR & Kn owledge Ma n a gem en t in 1998 , a n d IBM Corpora te Excellen ce Even t Awa rd in 1999 . Dr . Hu a n g left IBM a t 2001 to s ta r t h is own en t repren eu r ca reer in As ia ba s ed a t Ta iwa n . In 2002 , h e is th e Hon or Ch a ir Profes s or a t th e College of Ma n a gem en t of Na t ion a l Su n -Ya t-Sen Un viers ity, Ta iwa n a n d th e Ch ief Advis or to th e Ta iwa n ’s e-Govern m en t p rojects s in ce 2003 . His recen t res ea rch in teres ts in clu de ou ts ou rcin g, gr id com pu t in g, b ioin form a t ics , a n d m u lt im edia con ten t m a n a gem en t .


60


De ng-Chyan Che n

Ma n a gin g Director , USA Wes t Coa s t Office, In s t itu te for In form a t ion In du s t ry Pres iden t , In form a t ion In terch a n ge, In c

BIOGRAPHY Mr . Den g-Ch ya n Ch en , born in Ch a n g-Hwa , Ta iwa n , s ta r ted h is ca reer in Air Force s ervice. He gra du a ted from the Air Force Ins titu te of Aeronautical Technology , a n d received fu r th er con t in u in g edu ca t ion from Un ivers ity of Min n es ota . He h a d been pa r t icipa ted in a pp lyin g in form a t ion tech n ology to th e a u tom a t ion a n d in tegra t ion of logis t ic s u ppor t rela ted s ys tem s for Ta iwa n Air Force du r in g 1968 to 1972 . Th a t s ys tem wa s th e fir s t On -lin e Rea l Tim e com pu ter Sys tem in Ta iwa n .

1972 , Mr . Ch en join ed Con trol Da ta Ta iwa n Bra n ch a s Applica t ion An a lys t . 1977 prom oted a s Com pu ter Cen ter m a n a ger . 1987 led a tea m to work on En ergy Ma n a gem en t p roject in Min n ea polis , Min n es ota . Mr . Ch en h a d s u cces s fu lly a ccom plis h ed Ta iwa n , J ia n gs u , a n d Zejia n g Power Dis pa tch in g & Con trol Projects .

1992 , Mr . Ch en retu rn ed to Ta iwa n a n d join ed III a s a Project m a n a ger for Cu s tom s Au tom a t ion a n d Na t ion a l Hea lth In form a t ion Network p rojects . Th e s u cces s fu l im plem en ta t ion of th es e p rojects h a s res u lted in reloca ted Mr . Ch en to Silicon Va lley. 1996 , Mr . Ch en wa s n a m ed th e Ma n a gin g Director of USA Wes t Coa s t office of Ins titu te for In form ation Ind us try (III) with th e m is s ion to a s s is t IT tech n ologies a n d ta len t t ra n s fer between Ta iwa n a n d Nor th Am er ica .


61


Hs in-Kuo Kan

AT&T Middletown , New J ers ey (732) 420-0120 (Office)

h ka n @a t t .com

BIOGRAPHY Hs in Ka n is Divis ion Manage r, Com put ing Ce nte r Of Exc e lle nc e at AT&T Labs . He is cu r ren t ly res pon s ib le for th e des ign a n d developm en t of AT&T’s Elect ron ic (In tern et ) Servicin g Pla t form , a n d m a n a gem en t of R&D’s s ys tem ca p ita l a n d en terpr is e licen s e a greem en t with ven dors Hs in join ed Be ll Laboratorie s in 1976 . He h a s worked on va r iou s a s s ign m en ts (In Bell La bora tor ies , Am er ica n Bell, AT&T In form a t ion Sys tem s , a n d AT&T La bs ) in th e a rea s of da ta n etwork in g, com m u n ica t ion s s oftwa re developm en t , a n d n etwork opera t ion s developm en t . At AT&T, Hs in led a n d m a n a ged th e developm en t of Accu m a s ter¹ In tegra tor , Accu m a s ter¹ Service Works ta t ion s , Accu n et¹ T1 .5 In form a t ion Ma n a ger , Accu n et¹ Ba n dwid th Ma n a gem en t Service, a n d m os t recen t ly re-en gin eer in g of AT&T Bu s in es s Service As s u ra n ce Pla t form a n d En terpr is e Por ta l (a t t .com ) Hs in received a Doctor of Scien ce (Sc.D) degree in Elect r ica l En gin eer in g a n d Com pu ter Scien ce from M.I.T. in 1976 , a n d a Ba ch elor of Scien ce degree in Elect r ica l En gin eer in g from Na t ion a l Ch ia o Tu n g Un iver is ty in Ta iwa n . He is a m em ber of IEEE, ACM, a n d Ph i Ta u Ph i Sch ola s t ic Hon or Society. He is a ls o a 1988 a n d 1990 recip ien t of th e AT&T Arc hit e c ture Awards for h is m a jor con t r ibu t ion s to AT&T’s Un ified Network Ma n a gem en t Arch itectu re a n d Reu s a b le Softwa re Pla t form Arch itectu re. In th e s u m m er of 1999 , Hs in wa s a ppoin ted AT&T Fe llow for con t in u ou s a n d ou ts ta n d in g con t r ibu t ion s in th e s u cces s fu l des ign a n d developm en t of m is s ion cr it ica l s ys tem s th a t m a n a ge AT&T Services .


62


Chintay Sh ih

In du s t r ia l Tech n ology Res ea rch In s t itu te Bldg.51 ,195 Sec.4 , Ch u n g Hs in g Rd . Ch u tu n g, Hs in ch u , Ta iwa n , ROC


BIOGRAPHY

Educ at ion:

Ph .D. E lect r ica l En gin eer in g , Pr in ceton Un ivers ity 1975 M.S. Ma n a gem en t , S ta n ford Un ivers ity 1985 B.S. E lect r ica l En gin eer in g, Na t ion a l Ta iwa n Un iv. 1968 Exper ien ce: Pres iden t of ITRI 1994 2003 Vice Pres iden t of ITRI 1989 1994 VP & Gen era l Director of ERSO/ ITRI 1984 1989 En gin eer Ma n a ger , Pla n t Ma n a ger of IC Cen ter , Depu ty


Sen ior En gin eer , Bu r rou gh ts , USA 1974 1976 !Curre nt Pos it ion ! Specia l Advis or of ITRI 2003 !Re c e nt advis ory pos it ions :

!


!


63


Ko-Yang Wang

Ph .D., Dis t in gu is h ed En gin eer Res ea rch a n d In n ova t ion Execu t ive, Bu s in es s Tra n s form a t ion

IBM Globa l Services Tel: 914-766-2233 Fa x: 914-766-9238

Em a il: kyw@u s .ibm .com

BIOGRAPHY Dr . Ko-Ya n g Wa n g is on e of th e 60 Dis t in gu is h ed En gin eers in IBM Globa l Services . He h a s over 20 yea rs of exper ien ce in IT a n d s pecia lizes in th e in n ova t ive u s es of tech n ology to s olve bu s in es s p rob lem s . He h a s a wide ra n ge of in -dep th exper t is e in a rea s in clu de: opera t ion a l bu s in es s des ign , bu s in es s p roces s in tegra t ion a n d a u tom a t ion , bu s in es s a n d tech n ica l a rch itectu re, kn owledge m a n a gem en t , colla bora t ion , kn owledge m in in g, en terpr is e por ta ls , s oftwa re reu s e, pa ra llel com pilers , a n d a r t ificia l in telligen ce. Dr . Wa n g is th e Res ea rch a n d In n ova t ion Execu t ive in Bu s in es s Tra n s form a t ion , IBM Globa l Services . In a dd it ion to bein g th e foca l poin t for Globa l Services / Res ea rch rela t ion s h ip , h e lea ds a n IGS DE dr iven effor t ca lled "En terpr is e of th e Fu tu re." Th is effor t focu s es on develop in g 2 -5 yea rs vis ion s of fu tu re bu s in es s a n d tech n ology ga m e ch a n gers to h elp IBM a n d it s cu s tom ers s et s t ra tegic d irect ion s a n d develop in n ova t ive th ou gh t a n d tech n ology lea ders h ip . In 2001 , Dr . Wa n g led a cros s fu n ct ion tea m on bu s in es s p roces s in tegra t ion a n d a u tom a t ion to h elp IBM t ra n s form in to a dyn a m ic e-bu s in es s . Dr . Wa n g wa s th e s en ior developm en t m a n a ger a n d ch ief a rch itect for th e IBM Globa l Services Kn owledge Ma n a gem en t Applica t ion Su ite wh ich in clu de s evera l a pp lica t ion s th a t won th e Gold Meda l of th e 1998 Giga Excellen ce a wa rd in a n d Kn owledge a n d Docu m en t Ma n a gem en t in Nor th Am er ica a n d th e Silver Meda l of th e 1999 WW Giga Excellen ce a wa rd for Kn owledge Ma n a gem en t . Th es e a pp lica t ion s were dep loyed to m ore th a n 100 ,000 IBM pra ct it ion ers wor ldwide. Ea r lier , Dr . Wa n g wa s a p r in cipa l in th e IBM Con s u lt in g Grou p . Dr . Wa n g led th e Meth ods a n d Tools tea m in th e En terpr is e Solu t ion St ru ctu re p roject of IBM Globa l In du s t r ies . Before join in g th e IBM Con s u lt in g Grou p , Dr . Wa n g wa s a Res ea rch Sta ff Mem ber in th e IBM Res ea rch . Th ere, h e con t r ibu ted to th e R&D of a dva n ced tech n ology for com pilers , p rogra m m in g en viron m en ts a n d ru n t im e s ys tem s . Pr ior to join IBM, Dr . Wa n g wa s a s en ior res ea rch fa cu lty a t Pu rdu e Un ivers ity. Dr . Wa n g wa s a wa rded a Ph . D. a n d a M.S. degree in com pu ter s cien ce from Pu rdu e Un ivers ity. He a ls o h a s a M.S. a n d a B.S. degree in Ma th em a t ics . Dr . Wa n g h a s pu b lis h ed m ore th a n 30 tech n ica l pa pers . He h a s p res en ted m ore th a n 40 in vited ta lks in m a jor u n ivers it ies , r es ea rch la bora tor ies a n d in tern a t ion a l con feren ces .


64

T6 - Tech n ica l Ses s ion 6 : Na n otech n ology (II)

Ses s ion Ch a ir

Ben(jam in Thom as Peng-nien) Chu

S ta te Un ivers ity of New York a t S ton y Brook BIOGRAPHY Personal Inform at ion Hom e Address : 27 View Road, Setau ket , New York 11733 Na tion a lity: U.S.A.; Na tu ra lized Febru a ry 13, 1968, U.S. Dis tr ict Cou rt of Kan sas City. Marita l Sta tu s : Marr ied, th ree ch ildren . Present Pos it ion: Dis t in gu ish ed Professor Ph on e: 631-632-7928 FAX: 631-632-6518 E-m a il: bch u @n otes .cc.su n ysb.edu Educat ion: B.S., m agn a cu m lau de, St . Norber t College, 1955 Ph .D., Corn ell Un ivers ity, 1959 Em ploym ent His tory: Resea rch Associa te with Peter J . W. Debye, Corn ell Un ivers ity 1958-1962. Ass is tan t Professor of Ch em is try, Un ivers ity of Kan sas 1962-1965 Associa te Professor of Ch em is try, Un ivers ity of Kan sas 1965-1968 Professor of Ch em is try, Sta te Un ivers ity of New York a t Ston y Brook 1968-1988 Ch a irm an , 1978-1985 Professor of Ma ter ia ls Scien ce an d En gin eer in g 1982- Leadin g Professor of Ch em is try, SUNY/ Ston y Brook 1988- Dis t in gu ish ed Professor , SUNY/ Ston y Brook 1992- Other Appointm ents : Brookh aven Na tion a l Labora tory Su m m er, 1957 Un iv. of New Sou th Wales , Au s tra lia Su m m er,1974 & 1994 Au s tra lian Na tion a l Un ivers ity Su m m er, 1974 Wayn e Sta te Un ivers ity, Detroit May-J u n e, 1975 Hokka ido Un ivers ity, J apan J u ly-Sept , 1975 Pekin g Un ivers ity, Fu dan Un ivers ity, PR Ch in a Au gu s t , 1979 & 1982 In s t itu te for Th eoret ica l Ph ys ics , Decem ber , 1982 Un iv. of Ca lif., San ta Ba rba ra Extern a l Exam in er in Ch em is try, 1986-1989 Ch in ese Un ivers ity of Hon g Kon g Scien ce Advisory Com m ittee, Hon g Kon g Un ivers ity 1995-1997 of Scien ce an d Tech n ology Ch in ese Am erican Ch em ica l Society, Boa rd of Directors 1995-1997 Editorial Boards: Associa te Editor , Ma ter ia ls Letters 1986-1989 Editor ia l Boa rd, J ou rn a l of Colloid 1986-1989 an d In terface Scien ce Editor ia l Advisory Boa rd, Macrom olecu les 1990-1992


65

Editor ia l Boa rd, Review of Scien tific In s tru m en ts 1993-1995 Editor ia l Advisory Boa rd, J ou rn a l of Polym er Scien ce 1990- Pa r t B (Polym er Ph ys ics ) Fe llowships , Spec ial Invitat ions and Honors : Pa r t icipan t of th e 1966 Stu dy Week on Molecu la r Forces , Pon tifica l Academ y of Scien ce, Va tican City, Rom e, Ita ly. Alfred P. S loan Res earch Fellow 1966-1968 John S im on Guggenheim Fellow 1968-1969 Invitat ions and Honors (cont inued): Vis iting Profes s or, Japan S ociety for the Prom otion of S cience (JS PS ) 1975-1976, 1992-1993 Hum bold t Aw ard for S en ior U.S . S cien tis ts 1976-1977 , 1992-1993 Dis t in gu ish ed Ach ievem en t Award in Na tu ra l Scien ce, 1981 St . Norber t College Fellow, Am erican In s t itu te of Ch em is ts Fellow, Am erican Ph ys ica l Society Honorary Profes s or of the Chines e Acad em y of S ciences 1992- High Poly m er Phy s ics Prize, Am erican Phy s ical S ociety 1993 Lan gm u ir Dis t in gu ish ed Lectu rer Award, Divis ion of 1994 Colloid an d Su rface Ch em is try, Am erican Ch em ica l Society Honorary Profes s or, Nank ai Univers ity 1996- Aw ard for Dis tinguis hed S ervice in Ad vancem ent of Poly m er S cience, S ociety of Poly m er S cience, Japan 1997 Honorary Profes s or, Xiam en Univers ity 1998- 1998 Ach ievem en t Award of Ch in ese In s t itu te of En gin eers / USA, Ou ts tan din g Ach ievem en t Award 1998 Lectures : Robert R. Gilpin Mem oria l Lectu re, Cla rkson Un ivers ity, 1996 Collabora tu s VI, Dis t in gu ish ed Lectu res in Ch em ica l an d Bioch em ica l En gin eer in g, Ru tgers Un ivers ity, 1996 Research Interes ts : Tech n iqu es : Ray leigh, Brillouin and Ram an s cattering; Tim e-res olved s m all angle x-ray s cattering and w id e angle x-ray d if fraction; S m all angle neutron s cattering; Trans ient electric birefringence; Las er-ind uced f luores cence d etection Rheom etry ; Electros pinning. Topics : S tatic and d y nam ical properties of m acrom olecular, colloid al, and s upram olecular s olutions , Nanocom pos ites ; Biom ineralization; Poly electroly te-s urfactant com plexes ; Mod if ication of nanos tructured m aterials ; S upercritical f lu id s ; Mod if ied fullerenes ; Capillary electrophores is of DNA; Tis s ue engineering. Biod egrad able poly m ers for m ed ical applications ; Publicat ions : 490 scien tific papers , 5 book reviews , 6 books , 8 pa ten ts , 1 m eetin g report , 7 a r t icle

reviews , an d 17 papers in progress . Consultantships : 1 . Ca lgon Corpora t ion , Su bs idia ry of Merck & Co., In c., Pit tsbu rgh , PA. 2 . Brookh aven In s tru m en ts , Holtsville, New York. 3 . Un ivers it ies Space Resea rch Associa t ion (USRA), Microgravity Scien ce &


66

Applica t ion s Divis ion , NASA. 4 . Eas tm an Kodak Com pan y, Eas tm an Ch em ica ls Divis ion , Kin gsport , Ten n essee. 5 . Roch e Diagn os tic Sys tem s , Divis ion of Hoffm an n -LaRoch e, In c., Nu tley, New J ersey. 6 . Bris tol-Myers Squ ibb Com pan y, Th e Squ ibb In s t itu te for Medica l Resea rch , New Bru n swick, New J ersey.

7 . DuPont Experim ental S tation, Wilm ington, Delaw are 8 . W. L. Gore & Associa tes , In c., Elkton , Delaware. 9 . Dow Ch em ica l Com pan y, Freeport , Texas . Biographie s : Brief b iograph ies h ave been lis ted; for exam ples , in Am erican Men an d Wom en of Scien ce, Who’s Who in Am erica , Men of Ach ievem en t an d Am erican Catholic

Who’s Who.


67


"Th e Abn orm a l Den s it ies of Poly(L-la ct ic) Acid a n d It s Im plica t ion on Pr im a ry Nu clea t ion "

J ing Wu

As s is ta n t Profes s or Ot to H. York Depa r tm en t of Ch em ica l En gin eer in g

New J ers ey In s t itu te of Tech n ology Un ivers ity Heigh ts , Newa rk , NJ 07102-1982

BIOGRAPHY Dr . J in g Wu ’s res ea rch focu s es on s t ru ctu re developm en t a n d ph a s e t ra n s it ion s in polym er s ys tem s . His Ph .D. res ea rch wa s u n der th e s u pervis ion of Prof. J erold M. Sch u ltz of Un ivers ity of Dela wa re, du r in g wh ich h e h a d s tu d ied s t ru ctu re developm en t of polym er fibers u s in g in -s itu s yn ch rot ron s m a ll- a n d wide-a n gle x-ra y s ca t ter in g (SAXS, WAXS) tech n iqu es . Th e recen t work h a s been focu s ed on fu n da m en ta l u n ders ta n d in g of rea l-t im e ph a s e t ra n s form a t ion / crys ta lliza t ion in polym er s olu t ion s a n d gels .


68


Self-As s em bly of A Novel As ym m etr ica l Bola a m ph iph ile: Acid ic Soph orolip id Molecu les

Shuiqin Zhou

College of Sta ten Is la n d a n d Th e Gra du a te Cen ter , Th e City Un ivers ity of New York

ABSTRACT Th e s elf-a s s em bly of a n ovel a s ym m etr ica l bola a m ph iph ile of a cid ic s oph orolip id m olecu les , con s is t in g of a d is a cch a r ide s oph oros e lin ked to a n oleic a cid with a few u n iqu e s t ru ctu ra l fea tu res , h a s been in ves t iga ted in wa ter by ligh t m icros cope, FT-IR, s m a ll-a n gle a n d wide a n gle X-ra y s ca t ter in g, a s well a s s ta t ic a n d dyn a m ic la s er ligh t s ca t ter in g. Gia n t twis ted a n d h elica l r ibbon s of 5 -11mm wide a n d s evera l h u n dreds m icrom eters lon g cou ld be p rodu ced a t a cid ic con dit ion s . An in crea s e in pH va lu es in du ced a s t ru ctu ra l t ra n s it ion from th e fa s t -grown twis ted r ibbon s a t pH < 3 to th e s lowly-grown h elica l r ibbon s a t 3 .5 < pH < 5 .5 . No d ifferen ce wa s obs erved in both lon g per iod a n d s h or t per iod s pa cin g for th e d r ied a n d wa ter equ ilib ra ted r ibbon s a t d ifferen t pH va lu es . A m u lt ila m ella r s t ru ctu ra l m odel ba s ed on th e s t ron g d is a cch a r ide-d is a cch a r ide a n d ca rboxylic a cid -ca rboxlylic a cid h ydrogen bon din g a n d th e h ydroph obic a s s ocia t ion between th e oleic ch a in s wa s p ropos ed . Th e n eu t ra liza t ion of th e a cid ic s oph orolip id m olecu les with Na OH in wa ter to pH � 5 .9 p rodu ced clea r s olu t ion s with s h or t -ra n ge ordered n a n os t ru ctu res . At pH = 5 .9 , n ea r ly m on odis pers ed la rge m icelles orga n ized from a bou t 1 ,100 m olecu les with a h ydrodyn a m ic ra d iu s <Rh > of 111 n m a n d a ra t io of ra d iu s of gyra t ion <Rg> over <Rh > of 1 .2 were determ in ed , wh ile a t pH = 7 .8 , n ea r ly m on odis pers ed m icelles orga n ized from a bou t 790 m olecu les with a <Rh > of 98 n m a n d a m u ch la rger ra t io of <Rg>/ <Rh > of 1 .7 were determ in ed , in d ica t in g a m ore exten ded m orph ology. A cylin dr ica l b ru s h -like m icella r s t ru ctu ra l m odel wa s p ropos ed . Th e m ech a n is m s of th e pH-in du ced s t ru ctu ra l t ra n s it ion s of th e s elf-a s s em bled s oph orolip id m olecu les were d is cu s s ed . BIOGRAPHY Sh u iqin Zh ou received h er B.S. (1988) an d M.S. (1991) degrees from Xiam en Un ivers ity, P.R.Ch in a , an d th e Ph .D. (1996) degree from Th e Ch in ese Un ivers ity of Hon g Kon g. Sh e worked a s a Pos tdoctora l Resea rch Associa te in SUNY a t Ston y Brook with Professor Ben jam in Ch u du rin g 1996-2000, an d a Sen ior Ch em is t in Un ion Ca rbide/ Th e Dow Ch em ica l Com pan y du rin g 2000-2002, respectively. Sin ce Septem ber 2002, sh e h as been an Associa te Professor of Ch em is try, Th e City Un ivers ity of New York a t College of Sta ten Is lan d. Sh e h as pu blish ed 55 resea rch papers an d book ch apters . With th e NSF su pport , h er grou p resea rch es cu rren tly focu s on th e self-a s sem bly of specia l am ph iph ilic m olecu les , su ch a s n ovel fu lleren e der iva t ives , bolaam ph iph ilic glycolipids , an d block/ gra ft copolym ers in d ifferen t en viron m en ts to (1 ) fu n da m en ta lly u n ders ta n d th e in term olecu la r in tera ct ion s a t th e n a n om eter s ca le a n d (2 ) to regu la te th e n a n os t ru ctu res of th e s u pra m olecu la r a s s em blies for a pp lica t ion s in a dva n ced tech n ologies a n d b io-m edica t ion s .


69


Na n os t ru ctu red Ma ter ia ls for Adva n ced Sen s or Tech n ology

Chuan-J ian Zhong

Depa r tm en t of Ch em is t ry Sta te Un ivers ity of New York a t Bin gh a m ton

Bin gh a m ton , New York 13902 cjzh on g@bin gh a m ton .edu

ABSTRACT Th e ra p id developm en t of m u lt id is cip lin a ry res ea rch on n a n os t ru ctu red m a ter ia ls h a s p rovided ch em is ts with u n preceden ted oppor tu n it ies to a ddres s va r iou s fu n da m en ta l a n d tech n ologica l ch a llen ges . We h a ve been in ves t iga t in g a gen era l bot tom -u p pa th wa y for a s s em blin g n a n os t ru ctu red m a ter ia ls from core-s h ell n a n opa r t icles (1~20 n m ). Th is pa th wa y exp lores a s in gle-s tep a s s em bly p roces s in volvin g in terpa r t icle cova len t bon din g, h ydrogen -bon din g, or m u lt iden ta te liga n d coord in a t ion by m olecu la r wires . Na n ocrys ta l cores of gold , a lloy a n d s em icon du ctor m a ter ia ls with orga n ic m on ola yer s h ells of d ifferen t fu n ct ion a l grou ps (e.g., th iols , th ioeth ers , ca rboxylic a cids , polym er ic m a tr ix, etc.) h a ve been s tu d ied a s m odel s ys tem s . Ou r focu s is th e a b ility to con t rol s ize, s h a pe, a n d s pa cin g towa rds n ovel elect ron ic, op t ica l, m a gn et ic a n d ca ta lyt ic p roper t ies . We h a ve s h own th a t th es e n a n os t ru ctu res a re ch em ica lly res pon s ive a n d fin e-tu n a b le, a n d p res en t in teres t in g oppor tu n it ies to a ddres s is s u es in a dva n ced ch em ica l a n d elect roch em ica l s en s in g tech n ologies . We will d is cu s s recen t res u lt s of a n in ves t iga t ion of ch em ica l s en s in g of n it roa rom a t ics , m eta ls a n d b iologica lly-releva n t a n a lytes . An im por ta n t em ph a s is is th e u n ders ta n d in g of th e cor rela t ion of th e u n iqu e n a n os t ru ctu res with elect ron ic con du ct ivity, in ter fa cia l m a s s flow, liga n d-fra m ework m olecu la r recogn it ion , a n d ca ta lyt ic p roper t ies . BIOGRAPHY Dr . Ch u a n -J ia n Zh on g is a n a s s is ta n t p rofes s or a t S ta te Un ivers ity of New York a t Bin gh a m ton . Du r in g h is gra du a te s tu dy a t Xia m en Un ivers ity a n d ea r ly pos tdoctora l a n d a s s ocia te res ea rch er a ppoin tm en ts a t Fr itz-Ha ber -In s t itu te, Un ivers ity of Min n es ota a n d Iowa Sta te Un ivers ity, h e h a d received a dva n ced t ra in in gs in m a n y fields in clu d in g a n a lyt ica l ch em is t ry, ph ys ica l ch em is t ry, m a ter ia ls ch em is t ry, s u r fa ce ch em is t ry, a n d elect roch em is t ry. Th e in terd is cip lin a ry n a tu re of h is res ea rch in teres ts is reflected by h is m ore th a n 70 peer -reviewed pu b lica t ion s on a wide ra n ge of top ics in clu d in g n a n opa r t icles , n a n os t ru ctu res , ca ta lys is , s en s ors , m olecu la r a s s em blies , m icroflu id ics , con du ct in g polym ers , a n d m in ia tu r ized a n a lyt ica l in s t ru m en ta t ion . He h a s in th e pa s t five yea rs expa n ded h is res ea rch in teres t to th e exp lora t ion of n a n otech n ology, focu s in g on s tu d ies of n a n os t ru ctu red m a ter ia ls for a dva n ced fu el cell ca ta lys ts a n d ch em ica l/ b iologica l s en s ors . His res ea rch la bora tory h a s developed n ew m eth ods a n d tech n iqu es to a ddres s both fu n da m en ta l a n d p ra ct ica l is s u es in th e des ign a n d fa br ica t ion of n a n opa r t icles a n d n a n os t ru ctu res for n a n otech n ologica l a pp lica t ion s . He is in ven tor / co-in ven tor of th ree US pa ten ts , with s evera l pen d in g th a t a re rela ted to n a n opa r t icle s en s in g a n d ca ta lys t m a ter ia ls . His res ea rch work is cu r ren t ly fu n ded by Na t ion a l Scien ce Fou n da t ion , Am er ica n Ch em ica l Society Pet roleu m Res ea rch Fu n d , Wor ld Gold Cou n cil, 3M, a n d Hon da .


70


Crys ta lliza t ion in Na n o-con fin em en t Cylin der a n d Dou ble Gyroid En viron m en ts

Le i Zhu

Un ivers ity of Con n ect icu t Email: [email protected]

ABSTRACT Mu lt ip le ph a s e m orph ologies h a ve been obs erved in a s em i-crys ta llin e polys tyren e-b -poly(eth ylen e oxide) (PS-b -PEO) d ib lock copolym er with a PEO volu m e fra ct ion of 37%. Th e s a m ple h a s a dou ble gyroid (DG) ph a s e a s ca s t from s olu t ion , a n d it exh ib it s cylin der ph a s e a fter it is s u b jected to a la rge a m plitu de m ech a n ica l s h ea r a t 110 °C. Upon a n n ea lin g a t 150 °C, th e m eta s ta b le cylin der ph a s e s ta r t s to t ra n s form ba ck to th e DG ph a s e. Sm a ll a n gle X-ra y s ca t ter in g a n d t ra n s m is s ion elect ron m icros copy tech n iqu es a re u s ed to s tu dy th e ph a s e t ra n s it ion s between th e cylin der a n d DG ph a s es . Us in g d ifferen t ia l s ca n n in g ca lor im etry, n a n ocon fin ed crys ta lliza t ion k in et ics in cylin der a n d DG ph a s es is s tu d ied . At low crys ta lliza t ion tem pera tu res (< 34 °C), th ere is n o obviou s d ifferen ce in th e crys ta lliza t ion k in et ics between th e cylin der a n d DG ph a s es , du e to rela t ively h igh n u clea t ion den s ity in n a n ocon fin ed s pa ces . At h igh crys ta lliza t ion tem pera tu res (> 35 °C), th e crys ta l growth ra te in th e DG ph a s e d ra s t ica lly decrea s es com pa red to th e cylin der ph a s e. Th is d ifferen ce ca n be a t t r ibu ted to th e m orph ologica l d ifferen ce between DG a n d cylin der ph a s es , s in ce th e DG ph a s e con ta in s con t in u ou s ly cu rved ch a n n els , wh ich a re d ifficu lt for PEO crys ta ls to grow in s ide.


71


New Na n opa r t icle Ca ta lys ts For Fu el Cells

Jin Luo*, Mathew M. Maye, Li Han, Nancy Kariuki, Peter Njoki, Lingyan

Wang, Chuan-Jian Zhong**

Department of Chemistry, State University of New York at Binghamton

Binghamton, New York 13902 * [email protected]; (** [email protected])

ABSTRACT Th e s tu dy of n a n os ized gold ca ta lys is h a s a t t ra cted in crea s in g in teres t beca u s e of th e d is covery of u n preceden ted ca ta lyt ic a ct ivity a n d s pecificity of gold a t n a n om eter s izes [1 ,2 ]. Th e ca ta lyt ic a ct ivity of s u ch m a ter ia ls requ ires th e a b ility to m a n ipu la te th e in terpa r t icle s pa t ia l a n d s u r fa ce a cces s p roper t ies [3 ]. Th is a b ility is in h eren t ly lin ked to th e con t rolla b le a ct iva t ion of th e core-s h ell n a n os t ru ctu re, or rem ova l or recon s t itu t ion of th e s h ell com pon en ts . In th is p res en ta t ion , we will d is cu s s recen t fin d in gs of a n in ves t iga t ion of core-s h ell a s s em bled gold a n d a lloy n a n opa r t icles a s ca ta lys ts for elect rooxida t ion of ca rbon m on ooxide a n d m eth a n ol. Th is in ves t iga t ion is a im ed a t u n ders ta n d in g th e s t ru ctu ra l a n d m orph ologica l evolu t ion of th e n a n opa r t icles on th e s u r fa ce of s u ppor t m a ter ia ls u pon ca ta lyt ic a ct iva t ion . Th e a ct iva t ion of th e ca ta lyt ic a ct ivity of th e ca ta lys ts ca n be con t rolled by m a n ipu la t ion of th e core-s h ell s t ru ctu re, in ter fa cia l rea ct ivity, a n d a dh es ion s to th e s u ppor t in g s u bs t ra te. Th es e fin d in gs h a ve im por ta n t im plica t ion s to th e des ign a n d proces s in g of n a n os t ru ctu red ca ta lys ts . We a re cu r ren t ly ca r ryin g ou t a th eoret ica l m odelin g of th e th erm a lly-in du ced effects in term s of s u r fa ce free en ergy a n d a dh es ion , a n d develop in g a n in -dep th u n ders ta n d in g of th e s ize evolu t ion a s a fu n ct ion of tem pera tu re a n d s u bs t ra te p roper t ies . BIOGRAPHY Dr . J in Lu o is a s en ior a s s ocia te s cien t is t work in g in th e Depa r tm en t of Ch em is t ry (C.J . Zh on g’s La bora tory) a t SUNY-Bin gh a m ton . He received h is Ph .D. in Ph ys ica l Ch em is t ry a t Xia m en Un ivers ity a n d th e Un ivers ity of Tokyo (1990), wh ere h is th es is res ea rch in volved ph otoelect roch em is t ry a n d s pect roelect roch em is t ry. Before join in g th e SUNY-Bin gh a m ton res ea rch tea m , h e wa s a n a s s ocia te p rofes s or a t Xia m en Un ivers ity a n d a vis it in g s cien t is t a t SUNY-Pots da m . His res ea rch in teres t in volves in ter fa cia l elect roch em is t ry, n a n opa r t icle ca ta lys is , s ca n n in g p robe m icros copy, a n d s pect roelect roch em ica l tech n iqu es . In h is ea r ly res ea rch a ppoin tm en ts , h e in ves t iga ted orga n ic m olecu la r m on ola yers in two d im en s ion u s in g elect roch em ica l tech n iqu es , a n d developed n ovel ch em ica l s ys tem s u s in g con fin ed en ch a n t la yer tech n iqu e, a n ew th ree-d im en s ion m icrofa br ica t ion tech n ology, wh ich were fu n ded by th e Na t ion a l Na tu ra l Scien ce Fou n da t ion of Ch in a . He a ls o in ves t iga ted ph otoa s s is ted ca ta lyt ic degra da t ion of en viron m en ta lly h a za rdou s orga n ic pollu ta n ts u s in g n a n os t ru ctu red elect rodes . He is cu r ren t ly develop in g a dva n ced n a n om a ter ia ls for n a n otech n ologica l a pp lica t ion s . On e focu s ed a rea is th e developm en t of n a n opa r t icle ca ta lys ts for fu el cells , s u ppor ted by both federa l a n d in du s t r ia l fu n d in g.


72

T7 - Tech n ica l Ses s ion 7 : MEMS (II)

Ses s ion Ch a ir

Sus an Z. Hua

Director , Bio-MEMS Fa cility a n d Res ea rch As s ocia te Profes s or Depa r tm en t of Mech a n ica l a n d Aeros pa ce En gin eer in g,

SUNY-Bu ffa lo, Bu ffa lo, NY 14260 Tel: 716-645-2593 ext . 2358

Em a il: zh u a @en g.bu ffa lo.edu

BIOGRAPHY Prof. Zon glu Hu a is th e Director of Bio-MEMS Cen ter in th e Sch ool of Medicin e a n d a ls o a n a d ju n ct a s s ocia te p rofes s or in th e Mech a n ica l a n d Aeros pa ce En gin eer in g Depa r tm en t a t SUNY-Bu ffa lo. Her res ea rch in teres ts in clu de Bio-MEMS, b ios en s ors , m icroflu id ic la b-on -a -ch ip , a s well a s Ba llis t ic Ma gn etores is ta n ce n a n om a ter ia ls . Dr . Hu a received h er Ba ch elor a n d Ma s ter degrees in Ph ys ics from Pek in g Un ivers ity in Ch in a , a n d Ph .D. degree in Ma ter ia l Scien ce a n d En gin eer in g from Un ivers ity a n d Ma ryla n d . After gra du a t ion , s h e wen t to NIST a s a pos tdoc a n d worked on m u lt ila yered Gia n t Ma gn etores is ta n ce (GMR) m a ter ia ls . Pr ior to join in g th e b io-MEMS cen ter a t in SUNY-Bu ffa lo, s h e worked in a p r iva tely own ed com pa n y in NH for s ix yea rs fir s t a s s en ior R&D s cien t is t a n d la ter a s th e tech n ica l d irector in ch a rge of th e Applica t ion s Divis ion . Th ere s h e wa s in volved in developm en t of n ew produ cts , s ca lin g u p p roces s , a n d a dva n cin g a pp lica t ion s . On e of th e m a in p rodu cts s h e developed wa s a m icrofa br ica ted m a gn et ic-ba s ed s en s or .


73


Ma gn et ic Colloids : From Na n os t ru ctu res to Com plex Sys tem s

We ili Luo

Depa r tm en t of Ph ys ics , Un ivers ity of Cen t ra l Flor ida , Or la n do, FL 32816

407-823-5855(O); em a il: lu o@u cf.edu

ABSTRACT Ma gn et ic colloids con s is t of m a gn et ic n a n opa r t icles s u s pen ded in n on m a gn et ic s olven t . Th e a b ility for pa r t icles to rea r ra n ge th em s elves in th e liqu id en viron m en t in res pon s e to pa r t icle in tera ct ion or extern a l in flu en ces give r is e to r ich ph en om en a ra n gin g from s elf a s s em bly of th e n a n opa r t icles , ga s -liqu id a n d liqu id-s olid t ra n s it ion of th es e pa r t icles , to n on lin ea r s pa t io-tem pora l pa t tern s . Applica t ion s from s tu dyin g th es e ph en om en a ca n be fou n d in a u tom obile s h ock a bs orbers , liqu id op t ica l devices , to d ru g delivery a gen ts . BIOGRAPHY CURRENT POSITION Profes s or , Depa r tm en t of Ph ys ics , Un ivers ity of Cen t ra l Flor ida . EDUCATION Dec. 1989 Ph .D., Ph ys ics , UCLA. Dis s er ta t ion : "Sp in Gla s s a n d Sp in Gla s s Like Ma ter ia ls ." Advis or : Prof. Ra ym on d. L. Orba ch Ma rch , 1985 Ma s ter , Ph ys ics , UCLA. Ma rch , 1982 BS, Ph ys ics , Pek in g Un ivers ity, Beijin g, Ch in a . EMPLOYMENT HISTORY 2002-pres en t Profes s or , Depa r tm en t of Ph ys ics , Un ivers ity of Cen t ra l Flor ida . 1996-2002 As s ocia te Profes s or , Depa r tm en t of Ph ys ics , Un ivers ity of Cen t ra l Flor ida 1992-1996 As s is ta n t Profes s or , Depa r tm en t of Ph ys ics , Un ivers ity of Cen t ra l Flor ida . 1990-1992 Pos tdoctora l Fellow, Th e J a m es Fra n ck In s t itu te a n d th e Depa r tm en t of Ph ys ics , Un ivers ity of Ch ica go. 1984-1989 Res ea rch As s is ta n t , Depa r tm en t of Ph ys ics , UCLA. 1984-1986 Tea ch in g As s is ta n t , Depa r tm en t of Ph ys ics , UCLA. HONORS 2003 Ou ts ta n d in g Res ea rch er , College of Ar ts a n d Scien ces , UCF 2001 Res ea rch In cen t ive Awa rd , UCF 1997 Pres iden t ia l Mer it Awa rd , UCF 1996 Wa n g Ku a n ch en g You n g Scien t is t Awa rd 1994 NSF You n g In ves t iga tor Awa rd , Con den s ed Ma t ter Ph ys ics . 1989 Gra du a te Wom a n of th e Yea r , UCLA. PROFESSIONAL ACTIVITIES


74

Au gu s t 2003 Advis ory Boa rd , 9 th In tern a t ion a l Con feren ce on Elect rorh eologica l Flu ids a n d Ma gn eto-rh eologica l Su s pen s ion s , Beijin g, Ch in a .

J u ly 2001 Vis it in g Profes s or , Th e In tern a t ion a l Cen ter for Th eoret ica l Ph ys ics , Tr ies te, Ita ly.

2001 In tern a t ion a l S teer in g Com m it tee, 8 th In tern a t ion a l Con feren ce on Elect rorh eologica l Flu ids a n d Ma gn eto-rh eologica l Su s pen s ion s , Nice Fra n ce

J u ly 2000 Scien ce Con s u lta n t , Un ited Na t ion Developm en t Progra m . Ma rch -J u n e 2000 Vis it in g Profes s or , Un ivers ity of Ha n n over , Ha n n over , Germ a n y. Ma rch 1999 Ch a ir , “Ma gn et is m Focu s ed Ses s ion : Ma gn et is m in Soft Ma t ter ,” Am er ica n Ph ys ica l Society Cen ten n ia l Meet in g, At la n ta , Georgia . J a n u a ry 1999 Co-Ch a ir , "Ma gn et ic Flu ids ," 12 th In tern a t ion a l Win ter Sch ool on

Con t in u ou s Media Mech a n ics , Perm , Ru s s ia . Nov. 1998 , Ch a ir , “Ma gn et ic Flu ids ,” 43rd An n u a l In tern a t ion a l Con feren ce on

Ma gn et is m a n d Ma gn et ic Ma ter ia ls , Mia m i, Flor ida . Ma rch 1996 Ch a ir , "Colloida l In tera ct ion s ," Am er ica n Ph ys ica l Society An n u a l Ma rch Meet in g, S t . Lou is , Mis s ou r i. Ma rch 1995 Ch a ir , "Fer roflu ids a n d Elect ro-Rh eologica l Flu ids ," Am er ica n Ph ys ica l Society An n u a l Ma rch Meet in g, Sa n J os e, Ca liforn ia . Ma rch 1992 Ch a ir , In vited Sym pos iu m "Slow Rela xa t ion ," Am er ica n Ph ys ica l Society An n u a l Ma rch Meet in g, In d ia n a polis , In d ia n a . 1990£1999 Ed itor ia l Boa rd , In tern a t ion a l J ou rn a l of Modern Ph ys ics B. 1990£1999 Ed itor ia l Boa rd , Modern Ph ys ics Let ter s B.

RESEARCH FUNDINGS 1 . Weili Lu o (PI), "Fu n da m en ta l a n d Applied Res ea rch on Fer roflu ids ." Na t ion a l Scien ce

Fou n da t ion You n g In ves t iga tor Awa rd , $312 ,500 . 1994-1999 . Co-PI: n on e

2 . Weili Lu o (PI), "Fu n da m en ta l a n d Applied Res ea rch on Fer roflu ids ." Ea s tm a n Koda k

Com pa n y, equ ipm en t-m a tch in g fu n d for NSF You n g In ves t iga tor Awa rd , $187 ,500 , 1995-2000 .

Co-PI: n on e.

3 . Weili Lu o (PI), “Field In du ced In s ta b ilit ies a n d Bifu rca t ion s in Ma gn et ic Flu ids ." Na t ion a l

Scien ce Fou n da t ion , $80 , 000 , 1998-1999 . Co-PI: n on e.

4 . Weili Lu o (PI), “Field -con t rolled Flu id ic Da m per ”, Lockh eed-Ma r t in Com pa n y, $85 ,000 , 1999-

2000 . Co-PI: n on e.

5 . Weili Lu o (PI), I-4 m a tch in g fu n d Ph a s e I for Lockh eed-Ma r t in Com pa n y, Un ivers ity of Cen t ra l

Flor ida , $55 ,000 , 1999-2000 . Co-PI: n on e.

6 . Weili Lu o (PI), I-4 m a tch in g fu n d Ph a s e II for Lockh eed-Ma r t in Com pa n y, Un ivers ity of

Cen t ra l Flor ida , $15 ,000 , 2000 . Co-PI: n on e.

7 . Weili Lu o (PI), "Exper im en ta l a n d Th eoret ica l In ves t iga t ion s on Field -in du ced In s ta b ilit ies in

Ma gn et ic Flu ids ." Na t ion a l Scien ce Fou n da t ion , $336 , 205 , 2000-2003 . Co-PI: n on e.

8 . Weili Lu o (PI), "In s ta b ilit ies in Ma gn et ic Flu ids in Ter res t r ia l a n d Microgra vity En viron m en ts ."

NASA, $66 ,000 , 2000-2003 . Co-PI: n on e.

9 . Weili Lu o (PI), "Self-As s em bly of Ma gn et ic Na n os t ru ctu res a n d It s Rela ted En a b lin g

Tech n ologies ," Na t ion a l Scien ce Fou n da t ion Na n os ca le In terd is cip lin a ry Res ea rch Tea m ,

$1 ,200 ,000 . 2001-2005 . (with fou r oth er Co-PIs ).


75

10 . Weili Lu o (PI), "Self-As s em bly of Ma gn et ic Na n os t ru ctu res a n d Rela ted En a b lin g Tech n o-

logies ," Un ivers ity of Cen t ra l Flor ida , $307 ,611 , Ma tch in g Fu n d for NSF, Au gu s t 2001-J u ly 2005 .

(with fou r oth er Co-PIs ).


76


Des ign a n d m icrofa br ica t ion of Bio-AFM ca n t ilevers / t ips

Xiaoyu Yang

Res ea rch Scien t is t , Nova s ca n Tech n ologies , In c. Tel: 716-940-1365 Fa x: 716-829-2569

Em a il: ya n gxia oyu @h otm a il.com

ABSTRACT Sin ce it s in cep t ion in 1986 , AFM h a s fou n d wides prea d u s e in s u r fa ce im a gin g a n d m a n ipu la t ion . Moreover , AFM’s h igh ver t ica l res olu t ion ca n be u s ed to p robe ch em ica l forces , a s s m a ll a s wea k in pN regim e. Th e m os t im por ta n t pa r t of a n effect ive AFM s etu p is th e ca n t ilever . Ca n t ilever ’s m orph ologica l a n d m ech a n ica l p roper t ies d icta te exper im en ta l lim its of a cqu is it ion ra te, s ign a l to n ois e ra t io (SNR) a n d m in im a l in tera ct ion force (Fm in ). A lever th a t is s u ita b le to im a ge h a rd s u r fa ces in a ir h a s a h igh -a s pect ra t io t ip a n d h igh res on a n t frequ en cy for fa s t a n d a ccu ra te da ta a cqu is it ion . However , vis cou s da m pin g coefficien t (R), s p r in g con s ta n t (k ) a n d Fm in n eed n ot be low beca u s e s a m ples a re h a rd a n d a ir is n ot a vis cou s m ediu m . Th u s , com m ercia lly a va ila b le ca n t ilevers a re fa br ica ted h u n dreds of m icron s lon g a n d m ore th a n a h a lf of a m icron th ick , with kHz ra n ge res on a n t frequ en cy a n d s pr in g con s ta n ts in N/ m . In con t ra s t , Bio-AFM (work in g on s oft s a m ples in a qu eou s m edia ) requ ires ca n t ilevers with s m a ll s p r in g con s ta n ts k in order to exa m in e s m a ll fea tu res a n d wea k forces . To produ ce ca n t ilevers th a t a re m ore s u ited for s en s it ive opera t ion in a vis cou s en viron m en t , s h or t a n d th in levers were des ign ed to both redu ce s pr in g con s ta n ts a n d to elim in a te d ifficu lt ies a s s ocia ted with AFM s etu ps a d ju s tm en t a n d fa br ica t ion p roces s . In cu r ren t des ign , a ca n t ilever h a s been fu n ct ion a lized in to th ree pa r ts : s t iff bea m , h in ge a n d a h ea d . Th e t ip is loca ted 200 m icron s a wa y from th e d ie, s epa ra ted by va r ia b le len gth of s t iff bea m a n d h in ge. Th is des ign a llows s t ra igh t -forwa rd in tegra t ion in to s ta n da rd AFM s etu ps . Moreover , th e effect ive lever , con s is t in g of th e h in ge a n d th e h ea d , is s h or t (15-60 m icron s ) a n d th in (<100n m ). Fa br ica ted levers h a ve s m a ll k (~ 0 .01N/ m ), h igh res on a n t frequ en cy (kHz) a n d low R. BIOGRAPHY Xia oyu Ya n g is cu r ren t ly a Res ea rch Scien t is t with Nova s ca n Tech n ologies , In c., Am es IW. He is res pon s ib le for des ign of m icro/ n a n o s ca le MEMS s t ru ctu res a n d AFM ca n t ilevers a n d t ips , ch a ra cter iza t ion / s im u la t ion of b io-MEMS device a n d h igh s en s it ive AFM probes a n d force m ea s u rem en t by AFM probes . He works a s a repres en ta t ive of Nova s ca n Tech n ologies a t CNF (Corn ell Na n ofa br ica t ion Fa cility) a n d Bioph ys ics Depa r tm en t a t S ta te Un ivers ity of New York a t Bu ffa lo (SUNY a t Bu ffa lo). Xia oyu Ya n g wa s a wa rded h is Ph D degree in Mech a n ica l En gin eer in g a n d Ma ter ia ls Scien ce by th e Sta te Un ivers ity of New York a t Bu ffa lo (SUNY a t Bu ffa lo).


77


Sequ en t ia l E lect rolyt ic Bu bble-Ba s ed Micro-Pu m p

Sus an Z. Hua

Director , Bio-MEMS Fa cility a n d Res ea rch As s ocia te Profes s or Depa r tm en t of Mech a n ica l a n d Aeros pa ce En gin eer in g,

SUNY-Bu ffa lo, Bu ffa lo, NY 14260 Tel: 716-645-2593 ext . 2358

Em a il: zh u a @en g.bu ffa lo.edu

ABSTRACT Developm en t of m icroflu id ic la b-on -a -ch ip tech n ology requ ires a ccu ra te con t rol of flu id flow with ea s y on -ch ip elect r ica l flow con t rol a t low power . Va r iou s m icrom a ch in ed pu m pin g s ch em es h a ve been developed . E lect rolyt ic bu bble-ba s ed pu m ps a re of in teres t s in ce th ey a re s im ple to m icrofa br ica te, n eed low power (m icrowa t ts ), a da p t ea s ily to va ryin g ch a n n el con figu ra t ion s , with res pon s e t im e for bu bble in fla t ion / defla t ion in th e m illis econ d ra n ge. An elect rolyt ic bu bble a ctu a ted m icropu m p h a s been fa br ica ted a n d ch a ra cter ized for dos in g a pp lica t ion s . Th e m icropu m p con s is t s of a s er ies of bu bbles form ed d irect ly in s ide a m icroflu id ic ch a n n el, a n d th e volu m e d is p la cem en t ch a ra cter is t ics of in fla t in g/ defla t in g elect rolyt ic bu bbles a re u t ilized to m ove th e liqu id a lon g th e ch a n n el. Prototype ch ips with five s equ en t ia l bu bbles were bu ilt u s in g s ta n da rd ph otolith ogra ph y tech n iqu es . Th e pu m p per form a n ce wa s ch a ra cter ized a s a fu n ct ion of th e volta ge requ ired to gen era te elect rolyt ic bu bbles of va ryin g s ize, pu ls e-wid th , t im e in terva l between pu ls es , a n d ba ckpres s u re; ea ch pa ra m eter bein g va r ied in depen den t ly. It wa s fou n d th a t th e s ize of th e bu bble, a n d h en ce th e qu a n t ity of liqu id d is p la ced , in crea s es with volta ge. Als o, th e pu m p ra te in crea s es with a redu ct ion in pu ls e-wid th a n d th e t im e in terva l between pu ls es . Th e op t im u m pu m p ra te of 24 n l/ m in , cor res pon din g to a flRZ�YHORFLW\�RI�� P�V��ZDV�REWDLQHG�IRU�WKH�FXUUHQW�FKDQQHO�VL]H�RI��[�� P�LQ�FURVV-s ect ion . Th e pu m p per form ed s u cces s fu lly a ga in s t ba ckpres s u res u p to 107 kPa . BIOGRAPHY Prof. Zon glu Hu a is th e Director of Bio-MEMS Cen ter in th e Sch ool of Medicin e a n d a ls o a n a d ju n ct a s s ocia te p rofes s or in th e Mech a n ica l a n d Aeros pa ce En gin eer in g Depa r tm en t a t SUNY-Bu ffa lo. Her res ea rch in teres ts in clu de Bio-MEMS, b ios en s ors , m icroflu id ic la b-on -a -ch ip , a s well a s Ba llis t ic Ma gn etores is ta n ce n a n om a ter ia ls . Dr . Hu a received h er Ba ch elor a n d Ma s ter degrees in Ph ys ics from Pek in g Un ivers ity in Ch in a , a n d Ph .D. degree in Ma ter ia l Scien ce a n d En gin eer in g from Un ivers ity a n d Ma ryla n d . After gra du a t ion , s h e wen t to NIST a s a pos tdoc a n d worked on m u lt ila yered Gia n t Ma gn etores is ta n ce (GMR) m a ter ia ls . Pr ior to join in g th e b io-MEMS cen ter a t in SUNY-Bu ffa lo, s h e worked in a p r iva tely own ed com pa n y in NH for s ix yea rs fir s t a s s en ior R&D s cien t is t a n d la ter a s th e tech n ica l d irector in ch a rge of th e Applica t ion s Divis ion . Th ere s h e wa s in volved in developm en t of n ew produ cts , s ca lin g u p p roces s , a n d a dva n cin g a pp lica t ion s . On e of th e m a in p rodu cts s h e developed wa s a m icrofa br ica ted m a gn et ic-ba s ed s en s or .


78

T8 - Tech n ica l Ses s ion 8 : Sys tem -on -Ch ip (II)

Ses s ion Ch a ir

Yu He n Hu

Un ivers ity of Wis con s in - Ma dis on Dept . E lec & Com p. En gr . Ma dis on , WI 53706 , USA

h u @en gr .wis c.edu

BIOGRAPHY Yu Hen Hu is a fa cu lty m em ber a t th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g, Un ivers ity of Wis con s in , Ma dis on . He received BSEE from Na t ion a l Ta iwa n Un ivers ity, a n d MSEE a n d Ph D degrees from Un ivers ity of Sou th ern Ca liforn ia . Pr ior to join in g Un ivers ity of Wis con s in , h e wa s fa cu lty in th e Elect r ica l En gin eer in g Depa r tm en t of Sou th ern Meth odis t Un ivers ity, Da lla s , Texa s . His res ea rch in teres ts in clu de m u lt im edia s ign a l p roces s in g, a r t ificia l n eu ra l n etworks , fa s t a lgor ith m s a n d des ign m eth odology for a pp lica t ion s pecific m icro-a rch itectu res , a s well a s com pu ter a ided des ign tools . He h a s pu b lis h ed m ore th a n 180 tech n ica l pa pers in th es e a rea s . Dr . Hu is a fellow of IEEE. He is a form er a s s ocia te ed itor (1988-1990) for th e IEEE Tra n s a ct ion of Acou s t ic, Speech , a n d Sign a l Proces s in g in th e a rea s of s ys tem iden t ifica t ion a n d fa s t a lgor ith m s . He is cu r ren t ly a s s ocia te ed itor of IEEE Sign a l Proces s in g let ter s (2002-2003), J ou rn a l of VLSI Sign a l Proces s in g, a n d Eu ropea n J ou rn a l of Applied Sign a l Proces s in g. He is a fou n din g m em ber of th e n eu ra l n etwork s ign a l p roces s in g tech n ica l com m it tee of IEEE s ign a l p roces s in g s ociety a n d s erved a s ch a ir from 1993-1996 . He is a form er m em ber of VLSI s ign a l p roces s in g tech n ica l com m it tee of th e s ign a l p roces s in g s ociety. He s erved a s th e s ecreta ry of th e IEEE s ign a l p roces s in g s ociety (1996-1998), a boa rd m em ber a t IEEE n eu ra l n etwork cou n cil, a n d is cu r ren t ly a s teer in g com m it tee m em ber of th e In tern a t ion con feren ce of Mu lt im edia a n d Expo on beh a lf of IEEE Sign a l p roces s in g s ociety.


79


Ba s eba n d Sign a l Proces s in g IC for Wireles s Com m u n ica t ion Sys tem s

Tz i-Dar Chiue h

Gra du a te In s t itu te of E lect ron ics En gin eer in g a n d Dept . of E lect r ica l En gin eer in g

Na t ion a l Ta iwa n Un ivers ity, Ta ipei, Ta iwa n 10617 Tel: +886-2-2363-5251 ext . 511

Fa x: +886-2-2363-8247 Em a il: ch iu eh @cc.ee.n tu .edu .tw

ABSTRACT Wireles s LAN da ta s ervices a s well a s voice a n d low-ra te da ta s ervices offered by cellu la r com m u n ica t ion s ys tem s n ow perm ea te th e h igh -tech s ociety a rou n d u s a n d th ey h a ve becom e in d is pen s a b le. With th e ever -in crea s in g dem a n d for a cces s s peed com e en d les s effor ts in a pp lyin g m ore a n d m ore s oph is t ica ted m odu la t ion / recep t ion tech n iqu es in com m u n ica t ion s ys tem s . In th e a rea of ba s eba n d com m u n ica t ion circu it s , exten s ive kn owledge in com m u n ica t ion th eory, EM wa ve propa ga t ion , RF elect ron ics , s ign a l p roces s in g, a n d circu it des ign is requ ired . In th is ta lk , I will fir s t p res en t a des ign m eth odology for d igita l ba s eba n d com m u n ica t ion IC, by wh ich we h a ve gen era ted s evera l s u cces s fu l com m u n ica t ion ICs . Th en , th e des ign of a n OFDM ba s eba n d receiver IC, a key com pon en t in h igh -ra te wireles s LAN, is p res en ted . We h a ve in tegra ted ca r r ier frequ en cy s yn ch ron iza t ion , s ym bol bou n da ry es t im a t ion , ch a n n el es t im a t ion a n d frequ en cy-dom a in equ a liza t ion in th is receiver . Th e com plexity a n d power con s u m pt ion of th e ch ip a re m in im ized by fu ll-cu s tom m em ory b locks , word-len gth op t im iza t ion , a n d in n ova t ive a rch itectu re. Th is ch ip h a s a core a rea of 4 .6 x 4 .1 m m 2. Wh en ru n n in g a t 20 MHz, th e ch ip con s u m es 66 m W from a 2 .3 -V s u pply. Mea s u red pa cket er ror ra tes in d ica te th a t th e ch ip ca n opera te relia b ly in a m u lt ipa th fa d in g en viron m en t . BIOGRAPHY Tzi-Da r Ch iu eh wa s born in Ta ipei, Ta iwa n on J u ly 3 , 1960 . In 1983 , h e received th e B.S.E .E . degree from th e Na t ion a l Ta iwa n Un ivers ity, Ta ipei, Ta iwa n . He a ls o received th e M. S . a n d Ph . D. degrees in elect r ica l en gin eer in g from th e Ca liforn ia In s t itu te of Tech n ology, Pa s a den a , Ca liforn ia , in 1986 a n d 1989 , res pect ively. S in ce 1989 , h e h a s been a t th e Depa r tm en t of E lect r ica l En gin eer in g, Na t ion a l Ta iwa n Un ivers ity, wh ere h e is p res en t ly a Profes s or . As of 2001 , h e is join t ly a ppoin ted by th e Gra du a te In s t itu te of E lect ron ics En gin eer in g. His res ea rch in teres ts in clu de in tegra ted circu it des ign for d igita l com m u n ica t ion a n d n eu ro-m orph ic s ys tem s . He h a s pu b lis h ed over 100 tech n ica l pa pers a n d h olds 7 Ta iwa n es e pa ten ts a n d 4 US pa ten ts . He a ls o received th e 2003 Na t ion a l Scien ce Cou n cil Tech n ology Tra n s fer Awa rd for h is con t r ibu t ion in develop in g a n d t ra n s fer r in g two tech n ologies , W-CDMA ba s eba n d receiver a n d OFDM WLAN ba s eba n d receiver , wh ich h a ve been t ra n s fer red to ITRI. Dr . Ch iu eh is a s en ior m em ber of th e In s t itu te of E lect r ica l a n d Elect ron ic En gin eers .


80


Ch a ra cter iza t ion of Logic Circu it Tech n iqu es for High Lea ka ge CMOS Tech n ologies

Ph illip Chin Charle s Zukows ki

Colu m bia In tegra ted Sys tem s La bora tory

Colu m bia Un ivers ity, New York , NY 10027 E-m a il: pch in @cis l.colu m bia .edu

ca z@colu m bia .edu

Ge orge Gris t e de

IBM T.J . Wa ts on Res ea rch Cen ter 1101 Kitch a wa n Roa d , Rou te 134

York town Heigh ts , NY 10598 E-m a il: gr is tede@u s .ibm .com

ABSTRACT Ch a n n el s u b th res h old a n d ga te lea ka ge cu r ren ts a re p red icted by m a n y to becom e m u ch m ore s ign ifica n t in a dva n ced CMOS tech n ologies a n d a re expected to h a ve a s u bs ta n t ia l im pa ct on logic circu it des ign s t ra tegies . To redu ce s ta t ic power , tech n iqu es s u ch a s th e u s e of m on oton ic logic a n d m a n a gem en t of va r iou s eva lu a t ion a n d id le m odes with in logic s ta ges m a y becom e im por ta n t op t ion s in circu it op t im iza t ion . In th is pa per , we pres en t a gen era l, m u lt ilevel m odel for logic b locks con s is t in g of logic ga tes th a t in clu de a wide ra n ge of op t ion s for s ta t ic power redu ct ion , in both th e dom a in s of topology a n d t im in g. Exis t in g circu it tech n iqu es a re cla s s ified with in th is fra m ework a n d exper im en ts a re p res en ted s h owin g h ow a s pects of per form a n ce m igh t va ry a cros s th is ra n ge in a h ypoth et ica l tech n ology. A br ief d is cu s s ion follows on h ow circu it op t im iza t ion m igh t evolve in th e fu tu re. BIOGRAPHY Phillip Chin wa s born in Bos ton , MA in 1979 . In 2002 , h e received h is Ba ch elors of Scien ce degree (m a gn a cu m la u de) in Elect r ica l En gin eer in g from Brown Un ivers ity, Providen ce, RI. He is a m em ber of Ta u Beta Pi a n d Sigm a Xi h on ors s ociet ies . Cu r ren t ly, h e is a M.S./ Ph .D. ca n d ida te in Elect r ica l En gin eer in g in th e Colu m bia In tegra ted Sys tem s La bora tory a t Colu m bia Un ivers ity, New York , NY. S ta r t in g in 2003 , h e h a s been a Res ea rch Sta ff In tern a t th e IBM T.J . Wa ts on Res ea rch Cen ter , York town Heigh ts , NY. His cu r ren t work a n d in teres ts in volve h igh per form a n ce, low power , a n d low lea ka ge circu it tech n iqu es for fu tu re tech n ology gen era t ion s . Ge orge Gris t e de wa s born in Mt . Kis co, NY, USA in 1962 . In 1984 h e gra du a ted from Colu m bia College with a B.A. degree in Profes s ion a l Opt ion En gin eer in g. In 1985 , 1988 , 1990 , a n d 1992 , h e received th e B.S., M.S., P.Ph il., a n d Ph .D. degrees from Colu m bia Un ivers ity, a ll in E lect r ica l En gin eer in g. His Ph .D. th es is dea lt with th e der iva t ion of a n ew m a th em a t ica l form u la t ion for a n a lyzin g th e con vergen ce p roper t ies of rela xa t ion -ba s ed s im u la t ion m eth ods . In 1992 , Dr . Gr is tede join ed th e IBM Th om a s J . Wa ts on Res ea rch Cen ter a s a Res ea rch Sta ff Mem ber wh ere h e h a s don e exten s ive work in th e a rea s of h igh -per form a n ce, low power circu it des ign a n d th e developm en t of a n ew gen era t ion of cu s tom CAD tools to s u ppor t s u ch des ign s .


81

His res ea rch in teres ts in clu de circu it des ign , a u tom a ted circu it ch eck in g a n d op t im iza t ion . Dr . Gr is tede is a m em ber of Ta u Beta Pi a n d Eta Ka ppa Kn u . Charle s Zukows ki wa s born in Bu ffa lo, NY in 1959 . He received th e B.S., M.S., a n d Ph .D. degrees in elect r ica l en gin eer in g from th e Ma s s a ch u s et t s In s t itu te of Tech n ology, Ca m br idge, MA, in 1982 , 1982 , a n d 1985 , res pect ively. S in ce 1985 , h e h a s been on th e fa cu lty a t Colu m bia Un ivers ity, wh ere h e n ow h a s th e t it le of Profes s or of E lect r ica l En gin eer in g, a n d wh ere h e a ls o s erved a s EE Depa r tm en t Ch a ir from 2000-2003 . He is cu r ren t ly As s ocia te Director of th e NY Microelect ron ics Des ign Cen ter (MDC) a n d Tech n ology Progra m Co-Ch a ir for th e GLSVLSI Con feren ce. Dr . Zu kows ki received a n NSF Pres iden t ia l You n g In ves t iga tor Awa rd in 1987 for res ea rch on VLSI CAD. He is a regu la r reviewer for IEEE jou rn a ls a n d con feren ces . His cu r ren t in teres ts in clu de CMOS circu it des ign a n d s pecia l a rch itectu res for s im u la t in g gen e regu la tory n etworks .


82


A Form a l Ver ifica t ion Pla t form for SoC

Pao-Ann Hs iung

Depa r tm en t of Com pu ter Scien ce a n d In form a t ion En gin eer in g Na t ion a l Ch u n g Ch en g Un ivers ity, Ch ia yi, Ta iwa n .

Tel: +886-5-2720411 ext . 33119 , Fa x: +886-5-2720859 E-m a il: h pa @com pu ter .org

ABSTRACT How to ver ify a Sys tem -on -a -Ch ip (SoC) h a s been a n im por ta n t is s u e in a n SoC des ign p roces s du e to it s com plexity. Th e ca pa city of t ra d it ion a l ver ifica t ion tech n iqu es s u ch a s s im u la t ion or em u la t ion is n o lon ger a dequ a te for SoC. Never th eles s , form a l ver ifica t ion th a t a llows exh a u s t ive covera ge a n d gen era tes cou n terexa m ples is expected to be a com plem en ta ry s olu t ion . Severa l res ea rch es on form a lly ver ifyin g a n SoC h a ve dem on s t ra ted it s fea s ib ility a n d ben efit s , bu t th e en t ra n ce ba r r ier is s t ill very m u ch h igh for en gin eers a s eviden ced by th e fa ct th a t th ere is n o p la t form -ba s ed u t ility for form a l ver ifica t ion of SoC. In th is work , a Form al Verif ication Platform (FVP) is p ropos ed . FVP a ccelera tes th e form a l ver ifica t ion of a n In tellectual Property (IP), ju s t a s a h a rdwa re p la t form a ccelera tes p rototype ver ifica t ion . Th e m odel ch ecker SGM is u s ed in FVP a n d cu r ren t ly we s u ppor t ARM AMBA a n d IBM CoreCon n ect ba s ed SoCs . BIOGRAPHY Pa o-An n Hs iu n g received th e B.S. degree in Ma th em a t ics a n d th e Ph .D. degree in Elect r ica l En gin eer in g from th e Na t ion a l Ta iwa n Un ivers ity, Ta ipei, Ta iwa n , in 1991 a n d 1996 , res pect ively. From 1996 to 2000 , h e wa s a pos t -doctora l res ea rch er a t th e In s t itu te of In form a t ion Scien ce, Aca dem ia Sin ica . From Febru a ry 2001 to J u ly 2002 , h e wa s a n a s s is ta n t p rofes s or in th e Depa r tm en t of Com pu ter Scien ce a n d In form a t ion En gin eer in g, Na t ion a l Ch u n g Ch en g Un ivers ity, Ch ia yi, Ta iwa n . He is cu r ren t ly a n a s s ocia te p rofes s or . Dr . Hs iu n g wa s th e recip ien t of th e 2001 ACM Ta ipei Ch a p ter Ku o-Tin g Li You n g Res ea rch er for h is s ign ifica n t con t r ibu t ion s to des ign a n d ver ifica t ion of elect ron ic s ys tem s . He h a s pu b lis h ed m ore th a n 80 pa pers in in tern a t ion a l jou rn a ls a n d con feren ces . He h a s been ta k in g a n a ct ive pa r t in s ervin g for in tern a t ion a l jou rn a ls a n d con feren ces . His m a in res ea rch in teres ts in clu de: SoC des ign a n d ver ifica t ion , em bedded s oftwa re s yn th es is a n d ver ifica t ion , rea l-t im e s ys tem des ign a n d ver ifica t ion , a n d h a rdwa re-s oftwa re codes ign a n d cover ifica t ion .


83

T9 - Tech n ica l Ses s ion 9 : Bioin form a t ics (II)

Medica l Gen om ics a n d Gen om e Medicin e: a com pu ta t ion a l p ra ct ice

S im on Lin

Ma n a ger , Bioin form a t ics Core Fa cility Du ke Un ivers ity Medica l Cen ter

Tel: 919-681-9646 Fa x: 919-681-8028

Em a il: Lin 00025@m c.du ke.edu

ABSTRACT Gen om ics a n d proteom ics a re d r ivin g th e ch a n ge of m edica l edu ca t ion a n d pra ct ices . My cu r ren t res ea rch focu s es on th ree m a jor d is ea s es : b ra in d is order , lu n g ca n cer , a n d b rea s t ca n cer . In th is ta lk , I will dem on s t ra te a n ew da ta m in in g a lgor ith m to d is covery h u m a n s equ en ce va r ia t ion s by exp loit in g expres s ion p rofile da ta . As a p roof of p r in cip le, we a pp lied th is m eth od to b rea s t ca n cer pa t ien ts , a n d qu ick ly d is covered a p reviou s ly u n kn own SNP. Th is tech n ica l in n ova t ion reu s es th e Affym etr ix da ta from expres s ion p rofilin g. Th u s , it h a s zero a dd-on expen s es of da ta a cqu is it ion , wh ich m a kes it a cos t -effect ive wa y to d is cover d is ea s e-rela ted gen e va r ia t ion s . As t im e perm its , I will a ls o d is cu s s th e m odelin g s tu dy of lu n g a n d bra in d is ea s es . BIOGRAPHY Dr . S im on Lin is th e tech n ica l m a n a ger of th e b ioin form a t ics core fa cility a t Du ke Un ivers ity Medica l Cen ter s in ce 1999 . He wa s a ppoin ted a s a res ea rch a s s is ta n t p rofes s or s in ce 2002 . His res ea rch in teres t in clu des m edica l gen om ics da ta m in in g a n d kn owledge d is covery. He ed ited th ree books on Microa r ra y Da ta An a lys is . Bes ides res ea rch , h e is tea ch in g Gen om e In form a t ics , a n ew cou rs e in th e Ph .D. p rogra m of Bioin form a t ics . Dr . Lin received h is M.D. degree from th e m edica l s cien t is t t r a in in g p rogra m a t Pek in g Un ivers ity Sch ool of Medicin e in 1996; a n d h is M.S. degree in m olecu la r b ioph ys ics from Un ivers ity of Nor th Ca rolin a a t Ch a pel Hill in 1999 . In th e 80s , h e wa s a lea d s oftwa re en gin eer in th e Golden Apple s oftwa re developm en t tea m . Produ cts focu s ed on icon -ba s ed m u lt ilin gu a l a n d m u lt im edia opera t in g s ys tem ru n n in g on Rockwell 6500 CPUs , in clu d in g Apple II, Com m odore 64 , a n d CEC com pu ters . In th e 90s , h e developed in teres ts in m edica l in form a t ics . His d is s er ta t ion p roject wa s a b ioin form a t ics s tu dy on m RNA s t ru ctu res . It r es u lted in a com pu ter p rogra m to op t im ize p rotein p rodu ct ion for b ioph a rm a ceu t ica l in du s t ry. Du r in g h is t ra in in g in b ioph ys ics a t th e Un ivers ity of Nor th Ca rolin a a t Ch a pel Hill, h e developed a h igh -th rou gh pu t d ru g s creen in g a s s a y a n d d is covered a n ovel a ct iva tor of a ca lciu m ch a n n el by com pu ta t ion a l ch em is t ry. He is th e fou n din g ch a ir of a n a n n u a l in tern a t ion a l con feren ce on th e Cr it ica l As s es s m en t of Microa r ra y Da ta An a lys is (CAMDA). He is on th e s cien t ific com m it tee of ACM BioKDD works h ops , a n d th e At la n t ic Sym pos iu m on Com pu ta t ion a l Biology. He is a ls o on th e boa rd of th e As s ocia t ion of Ch in es e Bioin form a t icia n s (ACBIX), a n on -profit orga n iza t ion regis tered in th e Sta te of Pen n s ylva n ia to p rom ote ca reer developm en t for Ch in es e b ioin form a t ics p rofes s ion a ls .


84

T9 - Tech n ica l Ses s ion 9 : Bioin form a t ics (II)

Norm a liza t ion for cDNA Microa r ra y Exper im en ts h a vin g m a n y Differen t ia lly Expres s ed Gen es

I-Shou Chang

In ves t iga tor , Pres iden t ’s La b

Director , Dept . of Res ea rch Res ou rces Na t ion a l Hea lth Res ea rch In s t itu tes , TAIWAN

TEL: 886-2-26534401 x8200 FAX: 886-2-87924751

Em a il: is ch a n g@n h r i.org.tw

ABSTRACT Th is ta lk d is cu s s es two n orm a liza t ion m eth ods for cDNA m icroa r ra y da ta in wh ich a s u bs ta n t ia l p ropor t ion of gen es d iffer in expres s ion between th e two m RNA s a m ples , or th ere is n o s ym m etry in th e expres s ion levels of u p / down -regu la ted gen es . Th e fir s t m eth od con cern s th e s itu a t ion th a t th ere a re n o con t rol DNA s equ en ces on th e s lide. Th e fir s t s tep of th is a pproa ch is to per form globa l n orm a liza t ion ba s ed on dye-s wa p exper im en ts , a n d th en u s e a s ta t is t ica l cr iter ion to s elect a s et of (a lm os t ) con s ta n t ly expres s ed gen es . Ba s ed on th is s et , in ten s ity depen den t n orm a liza t ion is ca r r ied ou t u s in g loca l regres s ion m eth od . Th e u s efu ln es s of th is m eth od is clea r ly dem on s t ra ted in s im u la t ion s tu d ies a n d in th e a n a lys is of rea l da ta s ets . In pa r t icu la r , it is s h own in th e s im u la t ion s tu d ies th a t th is m eth od iden t ifies gen es with a lower fa ls e pos it ive ra te a n d a lower fa ls e n ega t ive ra te th a n a com m on ly u s ed m eth od , wh en a la rge n u m ber of gen es a re tu rn ed u p or down . Th e s econ d m eth od con cern s th e s itu a t ion th a t th ere a re con t rol s equ en ces on th e s lide. Ca lib ra t ion cu rves rela t in g flu ores cen ce s ign a l in ten s it ies to gen e expres s ion a l levels a re con s idered in th e con text of Ba ys ia n is oton ic regres s ion , wh ich m a kes u s e of s m ooth p r iors on Bern s tein polyn om ia ls a n d Ma rkov Ch a in Mon te Ca r lo m eth ods to s tu dy th e is oton ic regres s ion p rob lem . Th e s econ d m eth od is a pp lied to iden t ity ea r ly on s et gen es in th e s tu dy of t ra n s cr ip t ion a l p rofilin g of Au togra ph a Ca liforn ica m u lt ip le polyh edros is viru s . BIOGRAPHY I-Sh ou Ch a n g is a n In ves t iga tor in th e Pres iden t ’s La b . a n d th e Director of th e Depa r tm en t of Res ea rch Res ou rces , Na t ion a l Hea lth Res ea rch In s t itu tes , Ta iwa n . His cu r ren t res ea rch in teres ts in clu de a n a lys is of cDNA m icroa r ra y da ta , gen et ic lin ka ge a n a lys is , a n d gen et ic ep idem iology wh ere a ge-of-on s et is th e m a in ph en otype. He works with h is s ta ff in th e Depa r tm en t of Res ea rch Res ou rces to m a ke Na t ion a l Hea lth In s u ra n ce Da ta a va ila b le for res ea rch ers in Ta iwa n , a n d to m a ke b iologica l s equ en ce a n a lys is tools , in clu d in g GCG a n d EMBOSS, freely a va ila b le to a ll in ves t iga tors in Ta iwa n . I-Sh ou Ch a n g received h is BS from Na t ion a l Ts in g-Hwa Un ivers ity, Hs in -ch u a n d Ph D from Colu m bia Un ivers ity . He join ed Na t ion a l Hea lth Res ea rch In s t itu tes , Ta iwa n in 2000 . He wa s As s ocia te Profes s or a n d Profes s or in th e Ma th em a t ics Depa r tm en t a t Na t ion a l Cen t ra l Un ivers ity, Ta iwa n from 1976 to 2001 . He h a s con du cted res ea rch in m a th em a t ica l s ta t is t ics , b ios ta t is t ics , a n d th eir a pp lica t ion n s .


85

T10 - Tech n ica l Ses s ion 10 : C4I(II): On Dem a n d Com pu t in g Tech n ologies

Ses s ion Ch a ir

C. Eric Wu

IBM T. J . Wa ts on Res ea rch Cen ter York town Heigh ts , NY 10598

Em a il: cwu @u s .ibm .com

BIOGRAPHY C. Er ic Wu received h is B.S. from Depa r tm en t of E lect r ica l En gin eer in g, Na t ion a l Ta iwa n Un ivers ity, Ta iwa n in 1981 , a n d M.S. a n d Ph .D. from Depa r tm en t of Com pu ter Scien ce a n d En gin eer in g, Mich iga n Sta te Un ivers ity in 1985 a n d 1987 , res pect ively. He join ed IBM Res ea rch in 1987 a n d h a s 16 yea rs of exper ien ce in th e in form a t ion tech n ology in du s t ry. As a s en ior m em ber of IEEE, h e h a s pu b lis h ed m ore th a n 50 tech n ica l pa pers a n d pa ten ts in com pu ter rela ted a rea s a n d received Bes t Pa per Awa rds a t ICPADS’96 a n d ISHPC’97 . He h a s been lea d in g s evera l res ea rch a n d developm en t p rojects in th e a rea s of Web-ba s ed s ys tem m a n a gem en t a n d Web/ Gr id s ervices s in ce 1999 , in clu d in g a Lin u x s ys tem m a n a gem en t fra m ework , CIMOM (Com m on In form a t ion Model Object Ma n a ger ) p roviders , a n d t ra ce gen era t ion a n d m u lt ip le Ga n t t ch a r t vis u a liza t ion for IBM Sca la b le Pa ra llel s ys tem s . His cu r ren t in teres ts in clu de Lin u x, res ou rce m a n a gem en t , Gr id com pu t in g, a n d a u ton om ic com pu t in g. Recen t ly h e lea ds a tea m a t IBM T. J . Wa ts on Res ea rch Cen ter a n d developed th e pa cka ge “Ma n a gea b ility Services for Lin u x”, a va ila b le a t h t tp :/ / a lph a works .ibm .com / tech / gem s th rou gh IBM Alph a Works -- a n IBM webs ite for down loa d in g p re-produ ct pa cka ges . Ma n a gea b ility s ervices a re Gr id s ervices with s en s ors a n d a ctu a tors for m a n a gin g s ys tem res ou rces . Th e pa cka ge is cu r ren t ly on e of th e top down loa ded pa cka ges in th e “Gr id Com pu t in g” zon e a t IBM Alph a Works .


86

T10 - Tech n ica l Ses s ion 10 : C4I (II): On Dem a n d Com pu t in g Tech n ologies

IBM On -Dem a n d Com pu t in g

Tan Lu

Sys tem Arch itect , Adva n ced Sys tem s In fra s t ru ctu re Arch itectu re IBM

Tel: 845-912-2193 Fa x: 845-432-9413

Em a il : ta n lu @u s .ibm .com

ABSTRACT In order to a ch ieve com pet it ive a dva n ta ge, bu s in es s es m u s t be a b le to a da p t to ch a n gin g con dit ion s a n d to rea ct qu ick ly to n ew oppor tu n it ies . Tim e to m a rket is es s en t ia l in toda y’s com pet it ive e-bu s in es s en viron m en ts a n d com pa n ies a re cr it ica lly depen den t on th e fu n ct ion s a n d s ervices p rovided by th eir IT in fra s t ru ctu res . Th e s in gle m os t defin in g ch a ra cter is t ic of th e On Dem a n d com pu t in g pa ra d igm is th e over r id in g goa l to tu rn In form a t ion Tech n ology (IT) in fra s t ru ctu res in to a powerfu l in s t ru m en t s u ppor t in g a n orga n iza t ion ’s bu s in es s ob ject ives . Th is requ ires a fu n da m en ta l ch a n ge in th e wa y th a t IT in fra s t ru ctu res a re des ign ed , bu ilt , a n d m a n a ged . Th a t is , bu ild in g a n exten da b le a n d in du s t ry-wide com pu t in g p la t form , con s is t in g of dyn a m ica lly com pos e-a b le com pon en ts with in du s t ry s ta n da rd in ter fa ces th a t vir tu a lizes requ ired res ou rces , a n d ca n be m a n a ged a u ton om ica lly. As a n exa m ple, th e on -lin e m edia a n d en ter ta in m en t in du s t ry will be u s ed to illu s t ra te th e va lu es of on -dem a n d com pu t in g. BIOGRAPHY Ta n Lu is cu r ren t ly a lea d a rch itect for IBM’s on -dem a n d com pu t in g in it ia t ive, ba s ed in Pou gh keeps ie NY. He is res pon s ib le for work in g with cu s tom ers to u n ders ta n d th eir rea l-life pa in -poin ts , a n d a rch itect in g on -dem a n d tech n ologies a lon g with oth er IBM lea d a rch itects to a ddres s in g th os e pa in -poin ts . In h is p reviou s a s s ign m en t , Ta n wa s a lea d a rch itect res pon s ib le for a rch itect in g th e I/ O s u bs ys tem s for IBM’s z990 m a ch in e. In both h is cu r ren t a n d p reviou s jobs , h e h a s been in volved with va r iou s s ta n da rds grou ps . Ta n Lu wa s a wa rded h is Ma s ters a n d Ba ch elor degrees in Elect r ica l En gin eer in g by th e Ca rn egie Mellon Un ivers ity (CMU), a n d is cu r ren t ly get t in g h is MBA in Colu m bia Un ivers ity’s Execu t ive MBA progra m . Ta n join ed IBM in 1999 a s a s ys tem a rch itect , a n d s in ce th en h a ve a rch itected m a n y produ cts th a t a re delivered to th e m a rket .


87


Proa ct ive a n d Au ton om ic Com pu t in g: A Softwa re-en a b lin g Pla t form for th e En terpr is e

Andy Le an

CTO a n d Fou n der , Sequ oia Broa dba n d , In c. 15821 Ven tu ra Blvd , En cin o, CA 91436 Tel: 818-379-2440 Fa x: 818-379-2433

a lea n @s equ oia broa dba n d .com

ABSTRACT Th e dep th a n d brea d th of m a n y com plex s ys tem s , m u ch like th a t of icebergs , m a y n ot be rea d ily a ppa ren t – bu t wh a t is s u bm erged a ls o keeps th em a floa t . Th e pa yba ck from deep ly rooted a u ton om ic com pu t in g will be fou n d in h ow s elf-m a n a gin g a n d s elf-cor rect in g fea tu res ca n be a lign ed with bu s in es s ob ject ives a n d proces s es to a llow IT s ta ff to bet ter s erve th e ever -ch a n gin g dem a n ds of th e bu s in es s wor ld . We s ee a u ton om ic com pu t in g a s a p recu rs or for on dem a n d com pu t in g th a t even tu a lly will lea d to th e con s u m pt ion of com pu t in g res ou rces – s u ch a s s erver ca pa city, s tora ge a n d ba n dwid th – m u ch like we s ee toda y th rou gh u t ilit ies for wa ter , n a tu ra l ga s a n d elect r icity. Fir s t , th ou gh , th e IT in du s t ry h a s to in corpora te s elf-m a n a gin g, s elf-cor rect in g a n d s elf-recover in g fea tu res th a t m a ke pos s ib le h igh ly relia b le, u n a t ten ded opera t ion s , wh ile m a in ta in in g res ou rces a n d ba n dwid th a t h igh a va ila b ility. Fu n da m en ta lly, th e fou n da t ion of a n y s oftwa re-en a b lin g p la t form for th e en terpr is e m u s t be bu ilt cor rect ly with th es e goa ls in m in d . Th e recen t developm en t of ou r a gile com pu t in g p la t form , Sequ oia Media Ma n a ger (SMM), p rovides exa m ples of h ow a rch itectu re a n d des ign rooted in s u ch a u ton om ic a n d proa ct ive com pu t in g con s idera t ion s ca n h elp in crea s e both a pp lica t ion s robu s tn es s a n d a gility – a n d in s o doin g h elp a wide va r iety of pos s ib le cu s tom ers bet ter m eet wh a t a re likely to be ever -ch a n gin g bu s in es s n eeds . Likely n ext s teps in th e evolu t ion of SMM’s a u ton om ic a n d proa ct ive ca pa b ilit ies a re a ls o exp lored with a n a lys is of h ow th ey a re likely to h elp en terpr is es dep loyin g bu s in es s s olu t ion s . La s t ly, th e rea l-wor ld ch a llen ges fa cin g ISVs in th is a ren a will be ou t lin ed with a n eye towa rds h elp in g a u ton om ic com pu t in g ga in even m ore t ra ct ion – a n d towa rds gen era t in g rea l-wor ld pa yba ck . BIOGRAPHY An dy G. Lea n is a co-fou n der a n d Ch ief Tech n ology Officer of Sequ oia Broa dba n d , In c., wh ich p rovides s oftwa re, s olu t ion s a n d s ervices for th e ta rgeted , m a n a ged delivery of d igita l m edia for dyn a m ic s ign a ge, e-lea rn in g, in -s tore TV, a n d k ios k n etworks . Mr . Lea n h a s over 20 yea rs of exper ien ce in th e com pu ter in du s t ry, in clu d in g 18 yea rs of exper ien ce in lea d in g m u lt im edia a n d telecom m u n ica t ion s p rojects a t IBM Th om a s J . Wa ts on Res ea rch Cen ter , IBM Telecom m u n ica t ion s a n d Media Solu t ion Un it a n d IBM Broa dca s t Solu t ion s Cen ter . Miles ton es in clu de th e des ign of th e fir s t IBM J PEG/ MPEG Codec PC boa rd , developm en t of m u lt ica s t IP n etworks for a u d io a n d video delivery over th e LAN a n d WAN, a n d th e p rototype of a p ilot n etwork for m u lt im edia s ervices over a n In t ra n et . In h is la ter pa r t of IBM ca reer , Mr . Lea n worked with IBM Telecom m u n ica t ion s a n d Media In du s t ry Solu t ion Un it wh ere h e led a tea m th a t la u n ch ed a Nea r Video On -Dem a n d s olu t ion for th e Ca ble a n d Broa dca s t In du s t ry. He a ls o con ceived a n d in it ia ted IBM's ADSL Broa dba n d


88

In tern et Fir s t -Of-A-Kin d s olu t ion , wh ich p rovided th e field t r ia l for b roa dba n d ca b le a n d ADSL n etworks for Telcos a n d CATV. Mr . Lea n a ls o repres en ted IBM in th e ADSL Foru m a n d con t r ibu ted to ADSL’s n etwork m a n a gem en t workgrou p in 1996 a n d 1997 . He h olds m a n y US a n d foreign pa ten ts , a s well a s IBM Res ea rch Divis ion a wa rds . In 1997 , h e wa s a n in vited Adju n ct Profes s or of CS/ EE Depa r tm en t of Polytech n ic Un ivers ity in New York .


89


On -Dem a n d Bu s in es s Colla bora t ion

Tian Chao

IBM Th om a s J . Wa ts on Res ea rch Cen ter 1101 Kitch a wa n Rd , Rou te 134

York town Heigh ts , NY 10598 , USA t ia n @u s .ibm .com

ABSTRACT Cu r ren t t ren ds in bu s in es s t ra n s form a t ion is in crea s in gly lea d in g to a n ou ts ou rcin g a n d on -dem a n d m odel, wh ere th e En terpr is e is n o lon ger con s idered a s in gle com pa n y, bu t a va lu e ch a in of com pa n ies in a com plex web . It is in th is en viron m en t th a t bu s in es s colla bora t ion , th e p roces s th rou gh wh ich two or m ore pa r t ies in tera ct , p rovides it s bes t va lu e, th rou gh a u tom a ted fa cilita t ion a n d m a n a gem en t of in form a t ion exch a n ge a n d con t rol. Th e On -Dem a n d Bu s in es s Colla bora t ion (OBC) tech n ology by IBM Res ea rch a im s a t p rovid in g a n in fra s t ru ctu re th a t s olves th e com plex bu s in es s colla bora t ion p rob lem s a cros s m u lt ip le en terpr is es . Th e in fra s t ru ctu re en a b les efficien t a n d effect ive bu s in es s in form a t ion exch a n ge, p roces s t ra ck in g, a n d vis ib ility con t rol. Th e Colla bora t ive Exch a n ge Protocols (CxP) crea ted for OBC overcom es th e s h or tcom in gs of oth er p rotocols , s u ch a s Ros et ta Net , wh ere a ll da ta m u s t be a ggrega ted before t ra n s m it t in g. In a dd it ion , CxP provides th e flexib ility to s en d n on s ta n da rd da ta with in th e s ta n da rd m ech a n is m a n d en a b les m on itor in g of s ta tes for both p roces s es a s well a s docu m en ts . Oth er On -Dem a n d a s pects to be d is cu s s ed a re th e CxP p lu g-in fra m ework to crea te a n d cu s tom ize p lu g-in bu s in es s colla bora t ion p rotocols , a n d th e Act ion Ma n a ger to p rovide a "Plu g-a n d Pla y" type of in tegra t ion of n ew a pp lica t ion s in to exis t in g bu s in es s p roces s in fra s t ru ctu re. An on -goin g p ilot en ga gem en t of th e OBC tech n ology is a t Ta iwa n , ba cked by govern m en t fu n d in g, pa r tn ered with th e In s t itu te for In form a t ion In du s t ry (III), with th e ob ject ive to crea te a n ew s ta n da rd for des ign colla bora t ion . An effor t h a s been s ta r ted with th e Ros et ta Net s ta n da rds com m it tee to in clu de th e CxP en a b lin g fra m ework a n d bu s in es s p roces s defin it ion s in to th e s ta n da rds s pecifica t ion . BIOGRAPHY Tia n Ch a o is a n Advis ory Softwa re En gin eer in th e e-Bu s in es s Solu t ion s a n d Au ton om ic Com pu t in g Depa r tm en t a t th e IBM T.J . Wa ts on Res ea rch Cen ter . Her work a t th e Res ea rch Divis ion h a s focu s ed on a da p t ive a n d colla bora t ive bu s in es s s olu t ion s , Web s ervices , a n d th e s ecu r ity in th e Bu s in es s Proces s a rea . Ms . Ch a o h a s developed a n d s u bm it ted fou r IBM a lph a Works tech n ologies in th e Web s ervices a rea . Sh e h a s a ls o filed m a n y pa ten ts a n d pu b lis h ed m a n y pa pers , s evera l of wh ich h a ve received bes t pa per a wa rds . Sh e wa s th e key developer for th e fir s t p rototype th a t in tegra tes Web Services with IBM WebSph ere Bu s in es s In tegra t ion Con n ect (WBIC), s h owca s ed a t m a jor con feren ces like J a va On e a n d Melded Con f. Sh e a ls o des ign ed th e en d-to-en d Web Services s ecu r ity m odel for a WBIC rela ted p la t form . In a dd it ion , Ms . Ch a o h a s been p rofiled in th e Wom a n En gin eer Ma ga zin e. Pr ior to join in g th e Res ea rch Divis ion , Ms . Ch a o worked a t IBM TPF Sys tem s Developm en t La b . Ms . Ch a o received a m a s ter's degree in Com pu ter Scien ce from Virgin ia Tech , a n d a ba ch elor ’s degree from Na t ion a l Ta iwa n Un ivers ity.


90


On -Dem a n d Bu s in es s Proces s Mon itor in g & Ma n a gem en t

J un-J ang (J J ) J e ng , Hen ry Ch a n g, Steve Bu ckley. Hu i Lei,

J os ef Sch iefer , Sh u bir Ka poor , Lia n ju n An , Pu Hu a n g

IBM T.J . Wa ts on Res ea rch Cen ter

York town Heigh ts , NY 10598 jjjen g@u s .ibm .com

ABSTRACT Th e growin g n u m ber of bu s in es s p roces s s olu t ion s dem a n ds p la t form s wh ich en a b le developers to bu ild m a n a gem en t a pp lica t ion s in a m ore efficien t m a n n er . We will p res en t a n a da p t ive p la t form , ca lled BPMM (Bu s in es s Proces s Mon itor in g & Ma n a gem en t), for m a n a gin g bu s in es s p roces s s olu t ion s . A bu s in es s p roces s s olu t ion a ffects m a n y en terpr is e en t it ies : m u lt ip le bu s in es s p roces s es , d ifferen t orga n iza t ion s , va r iou s execu t ion p la t form s , m u lt ip le t ra d in g pa r tn ers , a n d con s ta n t ly ch a n gin g bu s in es s con text . Bu ild in g p la t form s for bu s in es s p roces s s olu t ion s is a d ifficu lt ta s k . Th e developm en t of p la t form s for m a n a gin g bu s in es s p roces s s olu t ion s pos es a n even grea ter ch a llen ge. Th e BPMM pla t form is ou r res pon s e to th is ch a llen ge by crea t in g a n a da p t ive en viron m en t s o th a t developers ca n levera ge it to bu ild m a n a gem en t a pp lica t ion s in th e dom a in of bu s in es s p roces s s olu t ion m a n a gem en t . Es pecia lly, BPMM s u ppor ts on -dem a n d m on itor in g a n d m a n a gem en t via both a rch itectu re a n d policy fra m ework . Th e BPMM project is a join t effor t between SWG S&S a n d IBM Res ea rch . Th e BPMM in fra s t ru ctu re h a s in fa ct been a pp lied to va r iou s dom a in s in clu d in g in s u ra n ce, s u pp ly ch a in , logis t ics a n d ba n k in g; a n d h a s p roven to be a n effect ive p la t form to a ch ieve on -dem a n d m on itor in g a n d m a n a gem en t . Th e BPMM in fra s t ru ctu re will be p res en ted in th is ta lk , cover in g th e followin g s u b jects :

� BPMM Fou n da t ion � BPMM Policy Fra m ework � BPMM Arch itectu re & Im plem en ta t ion � BPMM Us e Ca s e Scen a r ios

We will a ls o in t rodu ce h ow th e BPMM in fra s t ru ctu re ca n be t rea ted a s a n a u ton om ic bu s in es s a ct ivity m a n a gem en t p la t form th a t s u ppor ts a com plete fu n ct ion a lity to s en s e, in terpret , p red ict , a u tom a te a n d res pon d to bu s in es s a ct ivit ies a n d a im s to decrea s e th e t im e it ta kes to m a ke th e bu s in es s decis ion s . Actu a lly, th ere s h ou ld be a lm os t zero-la ten cy between th e ca u s e a n d effect of a bu s in es s decis ion . Ou r a rch itectu re en a b les a n a lys is a cros s corpora te bu s in es s p roces s es n ot ifies th e bu s in es s of a ct ion a b le recom m en da t ion s or a u tom a t ica lly t r iggers bu s in es s opera t ion s , effect ively clos in g th e ga p between bu s in es s in telligen ce s ys tem s a n d bu s in es s p roces s es . Th e p res en ta t ion will focu s on dem on s t ra t in g h ow on -dem a n d m on itor in g a n d m a n a gem en t ca n be rea lized via th e BPMM in fra s t ru ctu re in a n a u ton om ic fa s h ion . BIOGRAPHY


91

J u n -J a n g J en g (J J ) join ed IBM Res ea rch in J a n u a ry, 1999 a n d is cu r ren t ly work in g for th e Depa r tm en t of e-Bu s in es s Solu t ion s a n d Au ton om ic Com pu t in g. He is s ervin g a s th e Tech n ica l Lea d for p roject Bu s in es s Proces s Mon itor in g & Ma n a gem en t (BPMM), wh ich is a ls o ca lled BAM-COSa R (Bu s in es s Act ivity Ma n a gem en t , Con t in u a l Opt im iza t ion , Sen s e-a n d-Res pon d). BPMM is a join t effor t between IBM Res ea rch (Wa ts on a n d Ha ifa La bs ) a n d SWG AIM. In 2002/ 2003 , th ree m iles ton es of BPMM h a ve been com pleted : (1 ) Nekem a in th e dom a in of in s u ra n ce colla bora t ion h u b , (2 ) MD for th e dom a in of Microelect ron ic Ma n u fa ctu r in g in Su pply Ch a in Ma n a gem en t a n d (3 ) Tra n s por ta t ion Ma n a gem en t Services for IGS/ SO. BPMM is on e of th e m a jor p ropella n ts for IBM’s p rodu ct offer in gs on Bu s in es s Act ivity Mon itor in g (BAM) from 2004 a n d beyon d . Pr ior to th e cu r ren t orga n iza t ion , J J J en g worked for th e Kn owledge Ma n a gem en t grou p work in g on th e p roject Deep Blu e. Before IBM, J J J en g worked for th e AT&T La bs a s Sen ior Mem ber of Tech n ica l S ta ff. Wh ile in AT&T, h e led th e developm en t effor ts on va r iou s telecom m u n ica t ion s ervice p rovis ion in g s ys tem s a n d , in th e m ea n t im e, ch a ired Object -Or ien ted Tech n ology Com m it tee for p rom ot in g OO tech n ologies to m a n y bu s in es s u n it s . He a n d h is tea m won 1997 AT&T Bes t Softwa re Awa rd . J J J en g ta u gh t in th ree u n ivers it ies : Th e George Wa s h in gton Un ivers ity (As s is ta n t Profes s or ), Ru tgers Un ivers ity (Adju n ct Profes s or ) a n d NJ IT (Adju n ct Profes s or ). J J J en g received h is doctora te degree in Com pu ter Scien ce from Mich iga n Sta te Un ivers ity in 1994 . He h a s pu b lis h ed m ore th a n 50 tech n ica l pa pers a n d filed 6 pa ten ts . He is a n IEEE m em ber .


92

Day2

Keyn ote Speech

Con feren ce Ch a ir

Ruby Le e

Pr in ceton Un ivers ity ABSTRACT Cyber s ecu r ity p rovides a s s u ra n ces a n d s a fegu a rds n eces s a ry for th e s m ooth fu n ct ion in g of cyber s pa ce in tera ct ion s a n d s ervices . Su ch in tera ct ion s a n d s ervices a re bu ilt u pon h a rdwa re a n d s oftwa re tech n ology for com pu t in g, com m u n ica t ion s a n d s tora ge. Yet h a rdwa re a n d s oftwa re tech n ology h a s n ot h a d t ru s twor th y opera t ion s a s a fu n da m en ta l des ign goa l. Ra th er , th e in crea s e in t ra n s is tors in ch ips , a n d ou r edu ca t ion a l a n d res ea rch effor ts , h a ve been d irected m a in ly towa rds im provin g per form a n ce, cos t a n d power in h a rdwa re, a n d im provin g fu n ct ion a lity, vers a t ility a n d ea s e-of-u s e in s oftwa re. Approa ch es to cyber s ecu r ity h a ve focu s ed on rea ct ive m ea s u res , per im eter s ecu r ity a n d s oftwa re im plem en ta t ion s . In con t ra s t , I p ropos e th a t it is t im e for a p roa ct ive a pproa ch to cyber s ecu r ity, wh ere every com pon en t - h a rdwa re, s oftwa re or n etwork in g - h a s t ru s twor th y opera t ion a s a p r im a ry des ign goa l. Arch itectu re for cyber s ecu r ity m u s t be defin ed a t m a n y levels . Wh ile s ecu r ity h a s been s tu d ied a n d a dded to d ifferen t s oftwa re levels , it is es s en t ia lly m is s in g a t th e globa l level a n d th e core h a rdwa re level. If we wa n t core h a rdwa re, in clu d in g p roces s ors , to be m ore res pon s ib le for cyber s ecu r ity, wh a t a rch itectu ra l fea tu res m u s t be in clu ded? How do we t ra n s la te bu s in es s a n d pers on a l s ecu r ity n eeds , in a dd it ion to m ilita ry a n d n a t ion a l s ecu r ity n eeds , in to s ca la b le tech n ology fea tu res ? How ca n we protect s ervice a va ila b ility n eeds from m a liciou s Dis t r ibu ted Den ia l of Service a t ta cks ? How ca n proces s ors p rovide a u th en t ica t ion , in tegr ity a n d con fiden t ia lity for e-com m erce a n d e-s ervices with ou t s a cr ificin g per form a n ce? How ca n a n t i-p ira cy m ech a n is m s a n d fa ir u s e both be p rovided in d igita l r igh ts m a n a gem en t? BIOGRAPHY Profe s s or Ruby B. Le e is th e For res t G. Ha m rick Profes s or of En gin eer in g a n d Profes s or of E lect r ica l En gin eer in g a t Pr in ceton Un ivers ity, with a n a ffilia ted a ppoin tm en t in th e Com pu ter Scien ce depa r tm en t . Sh e is th e d irector of th e Pr in ceton Arch itectu re La bora tory for Mu lt im edia a n d Secu r ity (PALMS). Her cu r ren t res ea rch is in des ign in g s ecu r ity a rch itectu re a t both th e globa l GRID a rch itectu re level a n d th e core p roces s or a rch itectu re level. Sh e h a s a ls o des ign ed PLX, a very fa s t , t in y, m u lt im edia -ca pa b le p roces s or for in form a t ion a pp lia n ces , a n d h er s tu den ts a re con t in u in g to im prove th e PLX tes t -bed for p roces s or a rch itectu re res ea rch , edu ca t ion a n d a u tom a t ic s yn th es is . Her grou p exp lores th e des ign of s ecu r ity fea tu res th a t ca n be in tegra ted in to m icroproces s ors , a pp lica t ion -s pecific in s t ru ct ion p roces s ors (ASIPs ) a n d s ys tem -on -ch ips (SOCs ). Her res ea rch a ls o in clu des a rch itectu re for very h igh -per form a n ce m icroproces s ors a n d s u percom pu ters on a ch ip . Prof. Lee tea ch es a n u n dergra du a te cou rs e in “Cyber Secu r ity” a n d a gra du a te cou rs e in “Proces s or Arch itectu res for New Pa ra d igm s .” Pr ior to join in g th e Pr in ceton fa cu lty in 1998 , Dr . Lee s erved a s ch ief a rch itect a t Hewlet t -Pa cka rd , res pon s ib le a t d ifferen t t im es for p roces s or a rch itectu re, m u lt im edia a rch itectu re a n d s ecu r ity a rch itectu re for e-com m erce a n d exten ded en terpr is es . Sh e wa s a key a rch itect in th e in it ia l defin it ion a n d th e evolu t ion of th e PA-RISC proces s or a rch itectu re u s ed in HP s ervers


93

a n d works ta t ion s . Sh e wa s th e tech n ica l lea d in th e fir s t CMOS PA-RISC m icroproces s or . As ch ief a rch itect for HP’s m u lt im edia a rch itectu re tea m , Dr . Lee led a n in ter -d is cip lin a ry tea m focu s ed on a rch itectu re to fa cilita te perva s ive m u lt im edia in form a t ion p roces s in g u s in g gen era l-pu rpos e com pu ters . Sh e p ion eered th e in t rodu ct ion of m u lt im edia in s t ru ct ion s in m icroproces s ors . Th is en a b led h er m u lt im edia tea m to p rodu ce th e in du s t ry’s fir s t r ea l-t im e, h igh fidelity, s t rea m in g MPEG video a n d a u d io p rodu ct im plem en ted en t irely in s oftwa re on low-en d com pu ters . Dr . Lee a ls o co-led a n In tel-HP m u lt im edia a rch itectu ra l tea m for IA-64 , recen t ly relea s ed in In tel’s Ita n iu m m icroproces s ors . Con cu r ren t with fu ll-t im e em ploym en t a t HP, Dr . Lee a ls o s erved a s Con s u lt in g Profes s or of E lect r ica l En gin eer in g a t S ta n ford Un ivers ity. Dr . Lee h a s a Ph .D. in Elect r ica l En gin eer in g a n d a M.S. in Com pu ter Scien ce a n d Com pu ter En gin eer in g, both from Sta n ford Un ivers ity, a n d a n A.B. with d is t in ct ion from Corn ell Un ivers ity, wh ere s h e wa s elected a College Sch ola r . Sh e is a Fellow of th e As s ocia t ion for Com pu t in g Ma ch in ery (ACM), a Fellow of th e In s t itu te for E lect r ica l a n d Elect ron ic En gin eers (IEEE), a n d a m em ber of Ph i Beta Ka ppa a n d Alph a La m bda Delta . Sh e h a s been gra n ted 115 U.S. a n d in tern a t ion a l pa ten ts , with s evera l pa ten t a pp lica t ion s pen d in g.


94

P3 - Plen a ry Ses s ion 3 : Sys tem -on -Ch ip

Ses s ion Ch a ir

Howard H. Che n

IBM Res ea rch Divis ion Th om a s J . Wa ts on Res ea rch Cen ter York town Heigh ts , New York , U.S.A.

BIOGRAPHY Dr . Howa rd Ch en received h is Ph .D. degree from th e Un ivers ity of Ca liforn ia , Berkeley, in 1987 . S in ce th en , h e h a s been with th e IBM Res ea rch Divis ion , Th om a s J . Wa ts on Res ea rch Cen ter , in York town Heigh ts , New York , wh ere h e is cu r ren t a res ea rch s ta ff m em ber . Dr . Ch en h a s received th e IBM In ven t ion Ach ievem en t Awa rd for 7 U.S. pa ten ts , th e IBM Res ea rch Divis ion Awa rd for con t r ibu t ion s to th e des ign a n d rea liza t ion of th e Allia n ce G4 m icroproces s or , th e IBM Ou ts ta n d in g Con tr ibu t ion Awa rd for th e des ign a n d rea liza t ion of th e Allia n ce G5 m icroproces s or , a n d th e IBM Res ea rch Divis ion Awa rd for th e des ign a n d im plem en ta t ion of Freewa y G7 m icroproces s or .


95


Ts uhan Che n

Director , ITRI La b a t CMU Profes s or , E lect r ica l a n d Com pu ter En gin eer in g

Ca rn egie Mellon Un ivers ity Pit t s bu rgh , PA 15213 , USA

Tel: 412-268-7536 Fa x: 412-268-3890

Em a il: t s u h a n @cm u .edu

BIOGRAPHY Ts u h a n Ch en h a s been with th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g, Ca rn egie Mellon Un ivers ity, Pit t s bu rgh , Pen n s ylva n ia , s in ce October 1997 , wh ere h e is n ow a Profes s or . He d irects th e Adva n ced Mu lt im edia Proces s in g La bora tory, s t r ivin g to tu rn m u lt im edia tech n ologies from s cien ce fict ion in to rea lity. He a ls o es ta b lis h ed a n d is th e cu r ren t d irector of th e “ ITRI La b a t CMU,” a colla bora t ive res ea rch la bora tory s pon s ored by In du s t r ia l Tech n ology Res ea rch In s t itu te (ITRI), a t on e m illion dolla r s a yea r , with res ea rch focu s on Sys tem -on -Ch ip (SoC) a n d m u lt im edia / s ecu r ity a pp lica t ion s . His res ea rch in teres ts in clu de m u lt im edia s ign a l p roces s in g a n d com m u n ica t ion , im plem en ta t ion of m u lt im edia s ys tem s , m u lt im oda l b iom etr ics , a u d io-vis u a l in tera ct ion , pa t tern recogn it ion , com pu ter vis ion a n d com pu ter gra ph ics , b ioin form a t ics , a n d bu ild in g colla bora t ive vir tu a l en viron m en ts . From Au gu s t 1993 to October 1997 , h e worked in th e Vis u a l Com m u n ica t ion s Res ea rch Depa r tm en t , AT&T Bell La bora tor ies , Holm del, New J ers ey, a n d la ter a t AT&T La bs -Res ea rch , Red Ba n k , New J ers ey, a s a s en ior tech n ica l s ta ff m em ber a n d th en a p r in cip le tech n ica l s ta ff m em ber . Ts u h a n h elped crea te th e Tech n ica l Com m it tee on Mu lt im edia Sign a l Proces s in g, a s th e fou n din g ch a ir , a n d th e Mu lt im edia Sign a l Proces s in g Works h op , both in th e IEEE Sign a l Proces s in g Society. His en dea vor la ter evolved in to th e fou n din g of th e IEEE Tra n s a ct ion s on Mu lt im edia a n d th e IEEE In tern a t ion a l Con feren ce on Mu lt im edia a n d Expo, both join in g th e effor ts of m u lt ip le IEEE s ociet ies . He is a ppoin ted th e Editor -in -Ch ief for IEEE Tra n s a ct ion s on Mu lt im edia for 2002-2004 . Before s ervin g a s th e Editor -in -Ch ief for IEEE Tra n s a ct ion s on Mu lt im edia , h e a ls o s erved in th e Editor ia l Boa rd of IEEE Sign a l Proces s in g Ma ga zin e a n d a s As s ocia te Ed itor for IEEE Tra n s . on Circu it s a n d Sys tem s for Video Tech n ology, IEEE Tra n s . on Im a ge Proces s in g, IEEE Tra n s . on Sign a l Proces s in g, a n d IEEE Tra n s . on Mu lt im edia . He h a s co-ed ited a book t it led Adva n ces in Mu lt im edia : Sys tem s , S ta n da rds , a n d Networks . Ts u h a n received th e B.S. degree in elect r ica l en gin eer in g from th e Na t ion a l Ta iwa n Un ivers ity in 1987 , a n d th e M.S. a n d Ph .D. degrees in elect r ica l en gin eer in g from th e Ca liforn ia In s t itu te of Tech n ology, Pa s a den a , Ca liforn ia , in 1990 a n d 1993 , res pect ively. He received th e Ch a r les Wilt s Pr ize for ou ts ta n d in g in depen den t res ea rch in Elect r ica l En gin eer in g lea d in g to a Ph .D. degree a t th e Ca liforn ia In s t itu te of Tech n ology. He h a s pu b lis h ed m ore th a n a h u n dred of tech n ica l pa pers a n d h olds fifteen U.S. pa ten ts . He is a recip ien t of th e Na t ion a l Scien ce Fou n da t ion CAREER Awa rd , t it led “Mu lt im oda l a n d Mu lt im edia Sign a l Proces s in g,” from 2000 to 2003 .


96


Sys tem -on -a -Ch ip Syn th es is

Niraj J ha

Depa r tm en t of E lect r ica l En gin eer in g Pr in ceton Un ivers ity

Pr in ceton , New J ers ey, U.S.A.

ABSTRACT Th ere h a s been a n exp los ive growth a n d in teres t in em bedded s ys tem s in th e la s t few yea rs . Em bedded s ys tem a pp lica t ion s ra n ge from con s u m er a pp lia n ces , s u ch a s m icrowa ve oven s , cellu la r ph on es a n d m u lt im edia s ys tem s , to la rge telecom s ys tem s em ployin g th ou s a n ds of p roces s ors . Ma n y em bedded s ys tem s a re por ta b le a n d ba t tery-dr iven . Hen ce, power op t im iza t ion is a key con s idera t ion for th em in order to p rolon g ba t tery life, a n d a llevia te th erm a l, pa cka gin g a n d relia b ility con cern s . For th e cos t -con s ciou s rea l-t im e em bedded s ys tem a ren a , join t ly op t im izin g s ys tem pr ice a n d power u n der per form a n ce con s t ra in ts is a n im por ta n t p rob lem . In th is ta lk , we will fir s t des cr ibe th e releva n t p rob lem s th a t n eed to be s olved in s ys tem -on -a -ch ip (SOC) s yn th es is , a n d th en des cr ibe a SOC s yn th es is a lgor ith m a n d tool ca lled MOCSYN, wh ich pa r t it ion s a n d s ch edu les em bedded s ys tem s pecifica t ion s to in tellectu a l p roper ty cores in a n SOC. MOCSYN s yn th es izes rea l-t im e s in gle-ch ip h a rdwa re-s oftwa re a rch itectu res u s in g a n a da p t ive m u lt iob ject ive gen et ic a lgor ith m . Th e u s e of m u lt iob ject ive op t im iza t ion a llows a s in gle s ys tem s yn th es is ru n to p rodu ce m u lt ip le SOC des ign s th a t t ra de off d ifferen t a rch itectu ra l fea tu res . It op t im izes SOC pr ice, power con s u m pt ion a n d a rea u n der h a rd rea l-t im e con s t ra in ts . It s olves th e p rob lem of p rovid in g clock s ign a ls to cores com pos in g th e SOC. It p rodu ces a bu s s t ru ctu re th a t ba la n ces ea s e of la you t with a redu ct ion in bu s con ten t ion . In a dd it ion , it ca r r ies ou t floorp la n b lock p la cem en t with in it s in n er loop a llowin g a ccu ra te es t im a t ion of globa l com m u n ica t ion dela ys a n d power con s u m pt ion . It is cu r ren t ly bein g com m ercia lized by a s ta r t -u p ca lled PDV Softwa re. BIOGRAPHY Nira j K. J h a received h is B.Tech . degree in Elect ron ics a n d Elect r ica l Com m u n ica t ion En gin eer in g from In d ia n In s t itu te of Tech n ology, Kh a ra gpu r , In d ia in 1981 , M.S. degree in Elect r ica l En gin eer in g from S.U.N.Y. a t S ton y Brook , NY in 1982 , a n d Ph .D. degree in Elect r ica l En gin eer in g from Un ivers ity of Illin ois , Urba n a , IL in 1985 . He is a Profes s or of E lect r ica l En gin eer in g a t Pr in ceton Un ivers ity. He is a n IEEE Fellow a n d th e Director of th e Cen ter for Em bedded Sys tem -on -a -ch ip Des ign fu n ded by New J ers ey Com m is s ion on Scien ce a n d Tech n ology. He is cu r ren t ly s ervin g a s a n Editor of IEEE Tra n s a ct ion s on Com pu ter -Aided Des ign , IEEE Tra n s a ct ion s on VLSI Sys tem s , J ou rn a l of E lect ron ic Tes t in g: Th eory a n d Applica t ion s (J ETTA), a n d J ou rn a l of Em bedded Com pu t in g. He h a s a ls o s erved a s th e Progra m Ch a irm a n of th e 1992 Works h op on Fa u lt -Tolera n t Pa ra llel a n d Dis t r ibu ted Sys tem s . He is th e recip ien t of th e AT&T Fou n da t ion Awa rd a n d th e NEC Precep tors h ip Awa rd for res ea rch excellen ce a n d NCR Awa rd for tea ch in g excellen ce. He h a s co-a u th ored th ree books t it led “Tes t in g a n d Relia b le Des ign of CMOS Circu it s ” (Klu wer , 1990), “High -Level Power An a lys is a n d Opt im iza t ion ” (Klu wer , 1998), a n d “Tes t in g of Digita l Sys tem s ”


97

(Ca m br idge Un ivers ity Pres s , 2003). He h a s a u th ored or co-a u th ored m ore th a n 230 tech n ica l pa pers ou t of wh ich s ix h a ve won Bes t Pa per Awa rds . A pa per of h is wa s a ls o s elected for th e ‘‘Th e Bes t of ICCAD: A collect ion of th e bes t IEEE In tern a t ion a l Con feren ce on Com pu ter -Aided Des ign pa pers of th e pa s t 20 yea rs .’’ He h a s received 11 U.S. pa ten ts . His res ea rch in teres ts in clu de low power h a rdwa re a n d s oftwa re des ign , com pu ter -a ided des ign of in tegra ted circu it s a n d s ys tem s , d igita l s ys tem tes t in g a n d d is t r ibu ted com pu t in g.


98

P4 - Plen a ry Ses s ion 4 : Bioin form a t ics

Ses s ion Ch a ir

Sue -J ane Wang

Th e Sta t is t ics Repres en ta t ive FDA In ter -Cen ter Ph a rm a cogen om ics / Ph a rm a cogen et ics Work in g Grou p

U.S. Food a n d Dru g Adm in is t ra t ion Em a il: wa n gs @cder .fda .gov

Adju n ct Profes s or , J oh n s Hopkin s Un ivers ity, Pa r t -Tim e En gin eer in g Sch ool, Ma ryla n d

BIOGRAPHY

Su e-J a n e Wa n g h a s been s ervin g a s th e Sta t is t ics Repres en ta t ive of FDA in ter -cen ter (Cen ter for Dru g Eva lu a t ion a n d Res ea rch , Cen ter for Device a n d Ra diologica l Hea lth , Cen ter for Biologics Eva lu a t ion a n d Res ea rch a n d Na t ion a l Cen ter for Toxicology Res ea rch ) Ph a rm a cogen om ics / Ph a rm a cogen et ics (PG) Work in g Grou p . Her roles a re twofold . On e is to p rovide s pecific lea ders h ip in d is cu s s in g s ta t is t ica l con cep ts / is s u es of ph a rm a cogen om ics / ph a rm a cogen et ics s tu dy des ign a n d da ta a n a lys is in th e m u lt i-d is cip lin a ry exper t en viron m en t . A m a in ob ject ive of th e PG Work in g Grou p wa s to d ra ft a gu ida n ce for in du s t ry on Ph a rm a cogen et ics a n d Ph a rm a cogen om ics : Clin ica l S tu d ies a n d In Vitro Dia gn os t ic Tes ts in Ma rket in g Applica t ion s for Hu m a n Dru g Produ cts a n d Biologica ls . Th e s ta t is t ica l con s idera t ion s ect ion of th is d ra ft gu ida n ce for in du s t ry h a s in corpora ted gen era l p r in cip les in th e s ta t is t ica l review of gen e expres s ion s tu d ies a n d gen om e s ca n DNA s tu d ies in th e con text of n on clin ica l exper im en ts a n d clin ica l t r ia ls . As a m em ber of th e PG Work in g Grou p , Dr . Wa n g is cu r ren t ly in volved in p la n n in g th e s econ d PG works h op on “Ph a rm a cogen om ics in Dru g Developm en t a n d Regu la tory Decis ion -Ma kin g: Th e Gen om ic Da ta Su bm is s ion (GDS) Propos a l.” Th e in ten t of th e works h op is to p rovide a foru m for m ore deta iled d is cu s s ion of th e Agen cy’s p ropos a l a n d is s u es rela ted to defin in g volu n ta ry s u bm is s ion of PG da ta from ph a rm a ceu t ica l d ru g/ b iologics / device s pon s ors , th e form a t a n d proces s for p res en t in g s u ch da ta , a n d th e p rocedu re for regu la tory review. Sh e received h er m a s ter degree from Un ivers ity of Ca liforn ia , Los An geles , CA a n d Ph .D. from Un ivers ity of Sou th ern Ca liforn ia . Dr . Wa n g’s m a jor res ea rch a n d a pp lica t ion a ct ivit ies in clu de con t rolled clin ica l t r ia ls ; gen et ic a n d ep idem iologic s tu d ies ; s ta t is t ica l m eth ods for a n a lys is of m icroa r ra y da ta a n d ph a rm a cogen om ics / ph a rm a cogen et ics da ta in d ru g developm en t ; a n d tea ch in g in b ios ta t is t ics . Her p rofes s ion a l a ct ivit ies in clu de Editor -in -Ch ief: In tern a t ion a l Ch in es e Sta t is t ica l As s ocia t ion (ICSA) Bu llet in ; Sect ion Editor : Con trovers ia l S ta t is t ica l Is s u es ; Mem ber : th e Boa rd of Directors , Pu b lica t ion com m it tee a n d Awa rd com m it tee of ICSA; Ch a ir : s ta t is t ics s es s ion s a n d b iotech n ology s es s ion s in con feren ces , s ym pos iu m , works h ops in clu d in g Ph a rm a cogen om ics Ses s ion a n d Gen om ics in Dru g Dis covery a n d Developm en t Ses s ion a t th e FDA/ In du s t ry works h op , Sta t is t ics in Gen et ic Ep idem iology a t th e ICSA a pplied s ta t is t ics s ym pos iu m , Bio-Ch ip Tech n ology a n d Da ta Min in g s es s ion a t th e Sym pos iu m on Biom edica l Tech n ology Developm en t , etc. Dr . Wa n g received FDA Awa rd of Mer it s , FDA ou ts ta n d in g s ervice a wa rds , FDA/ CDER Excellen ce in com m u n ica t ion Awa rd , a n d FDA/ CDER Excellen ce in An a lyt ica l Scien ce Awa rd .


99


La rge-Sca le Ph ylogen et ic Recon s t ru ct ion

Tandy Warnow

Co-Director , Cen ter for Com pu ta t ion a l Biology a n d Bioin form a t ics Un ivers ity of Pen n s ylva n ia

a n d th e Ra dcliffe In s t itu te for Adva n ced Stu d ies Tel: 617-496-5174

Em a il: ta n dy@cs .u texa s .edu

ABSTRACT Ph ylogen et ic t rees , a ls o kn own a s evolu t ion a ry t rees , m odel th e evolu t ion of b iologica l s pecies or gen es from a com m on a n ces tor . Ma jor a dva n ces in b iology h a ve been en a b led by m olecu la r s ys tem a t ics (th e in feren ce of evolu t ion from m olecu la r s equ en ces ), bu t a ccu ra te es t im a t ion s of deep evolu t ion a ry h is tor ies a re s t ill d ifficu lt : da ta a re n ot often s u fficien t in qu a lity or qu a n t ity, a n d m eth ods h a ve n ot yet s ca led u p to h a n d le da ta s et s izes s u ch a s will be n eeded to in fer th e Tree of Life. Wors e s t ill, th e Tree of Life is clea r ly n ot a t ree--bu t ra th er a ret icu la te n etwork , du e to th e occu r ren ce of s pecia t in g h ybr id iza t ion a n d h or izon ta l t ra n s fer of gen et ic m a ter ia l. In th is ta lk , I will d is cu s s s evera l of m y res ea rch p rojects , wh ich a re colla bora t ive with oth er com pu ter s cien t is t s a n d b iologis ts , a n d wh ich a re m a kin g s om e progres s on th es e p rob lem s . In pa r t icu la r , I will ta lk a bou t gen e order ph ylogen y, ret icu la te evolu t ion detect ion a n d repres en ta t ion , a n d la rge-s ca le ph ylogen y recon s t ru ct ion . BIOGRAPHY Ta n dy Wa rn ow, a fu ll p rofes s or of Com pu ter Scien ce a t th e Un ivers ity of Texa s a t Au s t in , is a d is crete a lgor ith m s res ea rch er wh os e res ea rch focu s is on th e developm en t of m eth ods for recon s t ru ct in g evolu t ion a ry h is tory in b iology a n d h is tor ica l lin gu is t ics . A m a in focu s of h er work is th e developm en t of m eth ods for s olvin g h a rd op t im iza t ion p rob lem s in la rge-s ca le ph ylogen et ics , a n d s h e em ploys both th eoret ica l m eth ods (p rovin g th eorem s a bou t th e s ta t is t ica l per form a n ce), a s well a s s im u la t ion s tu d ies , in order to p red ict per form a n ce of m eth ods . Ma th em a t ica l m odelin g is a ls o im por ta n t in h er res ea rch , a n d th es e m odels a re developed th rou gh clos e a n d lon g-term colla bora t ion s with dom a in s pecia lis t s . Wa rn ow received both h er B.A. a n d Ph .D. degrees in Ma th em a t ics (in 1984 a n d 1991 , res pect ively) from th e Un ivers ity of Ca liforn ia a t Berkeley; a fterwa rds s h e wa s a pos tdoctora l fellow of Mich a el Wa term a n a t th e Un ivers ity of Sou th ern Ca liforn ia , a n d a res ea rch er in th e Dis crete Algor ith m s Grou p a t Sa n d ia Na t ion a l La bora tor ies in Albu qu erqu e, New Mexico. Sh e s pen t s evera l yea rs a t th e Un ivers ity of Pen n s ylva n ia before join in g th e Un ivers ity of Texa s in 1999 . In a dd it ion to h er p r im a ry a ffilia t ion with Com pu ter Scien ce, Wa rn ow is a m em ber of s evera l gra du a te grou ps , in clu d in g Molecu la r Biology, Ecology, Evolu t ion , a n d Beh a vior , a n d Com pu ta t ion a l a n d Applied Ma th em a t ics . Sh e is a ls o Co-Director (with Da vid Hillis ) of th e Cen ter for Com pu ta t ion a l Biology a n d Bioin form a t ics a t th e Un ivers ity of Texa s a t Au s t in , a n d on th e boa rd of d irectors of th e In tern a t ion a l Society for Com pu ta t ion a l Biology. Sh e received th e Na t ion a l Scien ce Fou n da t ion You n g In ves t iga tor Awa rd in 1994 , a n d th e Da vid a n d Lu cile Pa cka rd Fou n da t ion a wa rd in 1996 .


100


Bioin form a t ics a n d Pa t tern Dis covery a t IBM

Danie l E. Plat t

Bioin form a t ics a n d Pa t tern Dis covery IBM T. J . Wa ts on Res ea rch Cen ter

York town Hgts , NY 10598 (914)945-1388

ABSTRACT Ou r pa t tern d is covery effor ts s eek to d is cover pa t tern s h idden in da ta , wh ich ca n in clu de t im e s er ies in gen e expres s ion wh ere levels a n d t im e dela ys m a y be p res en t , a s well a s con s erved pa t tern s in gen e a n d pep t ide s equ en ces . Pa t tern s in p r im a ry s t ru ctu res m a y be u s ed a s a voca bu la ry for fu n ct ion a l a n d s t ru ctu ra l a s s ign m en ts , wh ich m a y th en be u s ed to p red ict fu n ct ion a n d fea tu res of s t ru ctu re. Fu r th er , a pp lica t ion s ca n be m a de to iden t ify wh ich pa r ts of gen et ic s equ en ces code for s ta r t s a n d s tops , a s well a s th e pos s ib ility of iden t ifyin g gen es . BIOGRAPHY Da n iel E . Pla t t r eceived h is Ph D in con den s ed m a t ter th eoret ica l ph ys ics from Em ory Un ivers ity in 1992 , a n d is em ployed a t IBM T. J . Wa ts on Res ea rch Cen ter in th e Bioin form a t ics a n d Pa t tern Dis covery Grou p . His recen t in teres ts in clu de develop in g th e s ta t is t ica l s ide of tes ts of gen e expres s ion s tu d ies , a s well a s fin d in g rela t ion s h ips between th e geom etr ic a n d fu n ct ion a l in form a t ion in con s erved pr im a ry s t ru ctu re pa t tern s .


101


A Regu la tory Pers pect ive of Bioin form a t ics Da ta Gen era ted for Ph a rm a cogen om ics a n d Ph a rm a cogen et ics Stu d ies

Sue -J ane Wang,1 Larry J . Le s ko 2

1Th e Sta t is t ics Repres en ta t ive, 2Ch a irpers on

FDA In ter -Cen ter Ph a rm a cogen om ics / Ph a rm a cogen et ics Work in g Grou p

1Office of Bios ta t is t ics , Office of Ph a rm a coep idem iology & Sta t is t ica l Scien ce 2Office of Clin ica l Ph a rm a cology & Bioph a rm a ceu t ica l Scien ce, Office of Ph a rm a ceu t ica l Scien ce

Cen ter for Dru g Eva lu a t ion a n d Res ea rch , Food a n d Dru g Adm in is t ra t ion Em a il: wa n gs @cder .fda .gov

ABSTRACT It is a n t icipa ted th a t b ioin form a t ic a n a lys is of da ta gen era ted from gen om ic res ea rch , for exa m ple, to in ves t iga te a d ru g’s m ech a n is m of a ct ion , a d is ea s e s u b type s creen in g tool or a d ia gn os t ic device for a pa r t icu la r in d ividu a l or popu la t ion s u b type, will becom e a pa r t of th e n on clin ica l, clin ica l ph a rm a cology, a n d clin ica l t r ia l eva lu a t ion s in th e fores eea b le fu tu re. Th e b ioin form a t ic da ta of pa r t icu la r in teres t a re th os e gen era ted from h igh th rou gh pu t gen e expres s ion s ign a tu res , p roteom ics or DNA-ba s ed b iom a rker pa n els th a t h a ve a ppropr ia te p red ict ive power . Th e growin g in teres t of ph a rm a cogen om ics a n d ph a rm a cogen et ics s tu d ies in d ru g developm en t h a s p rom pted th a t regu la tory a t ten t ion be given to a s s es s in g b ioin form a t ic da ta du r in g regu la tory review. Recen t ly, th e Agen cy h a s p ropos ed a n in it ia t ive, ca lled Gen om ic Da ta Su bm is s ion , to en cou ra ge ph a rm a ceu t ica l d ru g s pon s ors to s u bm it ph a rm a cogen om ic da ta a lon g with b ioin form a t ic da ta a t a n a ppropr ia te level to en a b le lea rn in g a n d th e volu n ta ry exch a n ge of s cien t ific in form a t ion . Th e Agen cy feels th a t th is will h elp a dva n ce th e s cien ce a n d tech n ology, a n d a id in th e t im ely developm en t of a ppropr ia te regu la tory policies . In th is ta lk , we will p res en t th e cu r ren t regu la tory pers pect ive of b ioin form a t ic da ta th a t a re to be u s ed to eva lu a te a ph a rm a cologic d ru g effect . It s h ou ld be recogn ized th a t th is is a n evolvin g field a n d s ta n da rds a n d a s s es s m en t a pproa ch es a re likely to ch a n ge with t im e. BIOGRAPHY Su e-J a n e Wa n g h a s been s ervin g a s th e Sta t is t ics Repres en ta t ive of FDA in ter -cen ter (Cen ter for Dru g Eva lu a t ion a n d Res ea rch , Cen ter for Device a n d Ra diologica l Hea lth , Cen ter for Biologics Eva lu a t ion a n d Res ea rch a n d Na t ion a l Cen ter for Toxicology Res ea rch ) Ph a rm a cogen om ics a n d Ph a rm a cogen et ics (PG) Work in g Grou p . Her roles a re twofold . On e is to p rovide s pecific lea ders h ip in d is cu s s in g s ta t is t ica l con cep ts / is s u es of ph a rm a cogen om ics / ph a rm a cogen et ics s tu dy des ign a n d da ta a n a lys is in th e m u lt i-d is cip lin a ry exper t en viron m en t . Dr . Wa n g is cu r ren t ly a m em ber of th e s teer in g com m it tee in volved in p la n n in g a s econ d PG works h op on “Ph a rm a cogen om ics in Dru g Developm en t a n d Regu la tory Decis ion -Ma kin g: Th e Gen om ic Da ta Su bm is s ion (GDS) Propos a l.” Th e in ten t of th e works h op is to p rovide a foru m for m ore deta iled d is cu s s ion of th e Agen cy’s p ropos a l a n d is s u es rela ted to defin in g s u bm is s ion of b ioin form a t ics da ta from ph a rm a ceu t ica l d ru g/ b iologics / device s pon s ors , th e form a t a n d proces s for p res en t in g s u ch da ta , a n d th e p rocedu re for regu la tory review.


102

Dr. Wa n g received ‘FDA/ CDER Excellen ce in Com m u n ica t ion Awa rd ’ in 2000 . In 2001 , s h e a n d collea gu es received a grou p a wa rd ‘FDA Awa rd of Mer it ’ for colla bora t ive res ea rch on flexib le des ign s in clin ica l t r ia ls . Led by h er , two grou p a wa rds ‘FDA Ou ts ta n d in g Service Awa rds ’ a n d ‘FDA/ CDER Excellen ce in An a lyt ica l Scien ce Awa rd ’ were recogn ized for th eir s cien t ific a ch ievem en t in n on -in fer ior ity a ct ive con t rolled t r ia ls .


103

T11 - Tech n ica l Ses s ion 11 : Sys tem -on -Ch ip (III)

Ses s ion Ch a ir

Sao-J ie Che n

Na t ion a l Ta iwa n Un ivers ity

BIOGRAPHY Sa o-J ie Ch en received th e B.S. a n d M.S. degrees in elect r ica l en gin eer in g from th e Na t ion a l Ta iwa n Un ivers ity, Ta ipei, Ta iwa n , ROC, in 1977 a n d 1982 res pect ively, a n d th e Ph .D. degree in elect r ica l en gin eer in g from th e Sou th ern Meth odis t Un ivers ity, Da lla s , USA, in 1988 . S in ce 1982 , h e h a s been a m em ber of th e fa cu lty in th e Depa r tm en t of E lect r ica l En gin eer in g, Na t ion a l Ta iwa n Un ivers ity, wh ere h e is cu r ren t ly a fu ll p rofes s or . From 1985 to 1988 , h e wa s on lea ve from Na t ion a l Ta iwa n Un ivers ity a n d work in g towa rd h is Ph .D. a t Sou th ern Meth odis t Un ivers ity. Du r in g th e Fa ll of 1999 , h e wa s a vis it in g s ch ola r in th e Depa r tm en t of Com pu ter Scien ce a n d En gin eer in g, Un ivers ity of Ca liforn ia , Sa n Diego. Du r in g th e Fa ll of 2003 , h e is cu r ren t ly a n a ca dem ic vis itor a t IBM TJ Wa ts on Res ea rch Cen ter , York town Heigh ts . His cu r ren t res ea rch in teres ts in clu de: VLSI ph ys ica l des ign a u tom a t ion , Wireles s LAN a n d Blu etooth IC des ign , a n d SOC h a rdwa re/ s oftwa re co-des ign a n d s ys tem -level des ign . Dr . Ch en is a m em ber of th e Ch in es e In s t itu te of En gin eers , th e As s ocia t ion for Com pu t in g Ma ch in ery, th e IEEE Com pu ter a n d IEEE Circu it s a n d Sys tem s Societ ies .


104


Overview of NTU SOC Cen ter

Sy-Ye n Kuo

Ch a irm a n , Depa r tm en t of E lect r ica l En gin eer in g Na t ion a l Ta iwa n Un ivers ity

Tel: 886-2-23630946 Fa x: 886-2-23671909

Em a il: s yku [email protected] tu .edu .tw

ABSTRACT Th e Na t ion a l Ta iwa n Un ivers ity (NTU) Sys tem -on -Ch ip (SOC) Cen ter is es ta b lis h ed in yea r 2001 . Th e goa l is to com bin e th e res ea rch s t ren gth of NTU a n d in du s t r ia l res ou rces for th e developm en t of a dva n ced SOC tech n ologies a s well a s to in s p ire th e crea t ivity of th e in du s t ry a n d t ra n s form in g th e n ewly developed tech n ologies from a ca dem ic res ea rch works to p ra ct ica l p rodu cts . Th e u lt im a te goa l is to m a ke Ta iwa n th e wor ldwide lea der in SOC in du s t ry th rou gh s u ch a coopera t ion m ech a n is m . NTU SOC Cen ter h a s crea ted m a n y progra m s for fa cilita t in g th e in du s t r ia l IC com pa n ies to pa r t icipa te in res ea rch a n d edu ca t ion a l colla bora t ion s a t NTU. Th es e rela t ion s h ips a re h igh ly va r ied , in clu d in g pa r t icipa t in g in NTU s em in a rs / con feren ces / con s or t ia / works h ops , s pon s or in g res ea rch p rojects , m on itor in g res ea rch developm en ts a t NTU, fin d in g exper t con s u lta n ts from a m on g NTU fa cu lt ies , licen s in g NTU-own ed in tellectu a l p roper ty, en h a n cin g recru it in g ch a n n el of NTU gra du a tes a n d s tu den ts , pa r t icipa t in g in NTU con t in u in g a n d profes s ion a l edu ca t ion p rogra m s , a n d develop in g cu s tom ized res ea rch p rogra m s .

In th is ta lk , we will in t rodu ce th e deta ils of th e NTU SOC a ct ivit ies . Th rou gh th e in t rodu ct ion , we ca n s ee th e n ew colla bora t ion m odel a m on g a ca dem ic u n ivers ity a n d in du s t r ia l com pa n ies . With s u ch a n ew u n ivers ity-s u ppor ted m ech a n is m , we h a ve crea ted a win -win work in g m odel for th e developm en t of SOC tech n ologies in Ta iwa n . BIOGRAPHY Sy-Ye n Kuo received th e BS (1979) in Elect r ica l En gin eer in g from Na t ion a l Ta iwa n Un ivers ity, th e MS (1982) in Elect r ica l & Com pu ter En gin eer in g from th e Un ivers ity of Ca liforn ia a t Sa n ta Ba rba ra , a n d th e Ph D (1987) in Com pu ter Scien ce from th e Un ivers ity of Illin ois a t Urba n a -Ch a m pa ign . S in ce 1991 h e h a s been with Na t ion a l Ta iwa n Un ivers ity, wh ere h e is cu r ren t ly a p rofes s or a n d th e Ch a irm a n of Depa r tm en t of E lect r ica l En gin eer in g. He s pen t h is s a bba t ica l yea r a s a vis it in g res ea rch er a t AT&T La bs -Res ea rch , New J ers ey from 1999 to 2000 . He wa s th e Ch a irm a n of th e Depa r tm en t of Com pu ter Scien ce a n d In form a t ion En gin eer in g, Na t ion a l Don g Hwa Un ivers ity, Ta iwa n from 1995 to 1998 , a fa cu lty m em ber in th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g a t th e Un ivers ity of Ar izon a from 1988 to 1991 , a n d a n en gin eer a t Fa irch ild Sem icon du ctor a n d Silva r -Lis co, both in Ca liforn ia , from 1982 to 1984 . In 1989 , h e a ls o worked a s a s u m m er fa cu lty fellow a t J et Propu ls ion La bora tory of Ca liforn ia In s t itu te of Tech n ology. His cu r ren t res ea rch in teres ts in clu de m obile com pu t in g a n d n etworks , depen da b le d is t r ibu ted s ys tem s , s oftwa re relia b ility, a n d op t ica l WDM n etworks .


105

Profes s or Ku o is a n IEEE Fellow. He h a s pu b lis h ed m ore th a n 190 pa pers in jou rn a ls a n d con feren ces . He received th e d is t in gu is h ed res ea rch a wa rd (1997-2005) from th e Na t ion a l Scien ce Cou n cil, Ta iwa n . He wa s a ls o a recip ien t of th e Bes t Pa per Awa rd in th e 1996 In tern a t ion a l Sym pos iu m on Softwa re Relia b ility En gin eer in g, th e Bes t Pa per Awa rd in th e s im u la t ion a n d tes t ca tegory a t th e 1986 IEEE/ ACM Des ign Au tom a t ion Con feren ce(DAC), th e Na t ion a l Scien ce Fou n da t ion ’s Res ea rch In it ia t ion Awa rd in 1989 , a n d th e IEEE/ ACM Des ign Au tom a t ion Sch ola rs h ip in 1990 a n d 1991 .


106


PowerHerd : A Dis t r ibu ted Sch em e for Dyn a m ica lly Sa t is fyin g Pea k Power Con s t ra in ts in In tercon n ect ion Networks

Li Shang

Dept . of E lect r ica l En gin eer in g

Pr in ceton Un ivers ity Tel: 609-258-4108 Fa x: 973-884-5668

Em a il: ls h a n [email protected] in ceton .edu

ABSTRACT As in tercon n ect ion n etworks p rolifera te to a wide ra n ge of h igh -per form a n ce s ys tem s , power con s u m pt ion is becom in g a s ign ifica n t a rch itectu ra l is s u e. In in tercon n ect ion n etworks , th e pea k power con s u m pt ion d irect ly a ffects th e s olu t ion for pa cka ge coolin g a n d power delivery des ign . Off-lin e wors t -ca s e power a n a lys is is typ ica lly u s ed to es t im a te n etwork pea k power con s u m pt ion a n d gu a ra n tee s a fe on -lin e opera t ion , wh ich n ot on ly in crea s es s ys tem cos t bu t a ls o con s t ra in s n etwork per form a n ce. In th is work , we pres en t a n on -lin e m ech a n is m , ca lled PowerHerd , to efficien t ly m a n a ge n etwork power res ou rces in a d is t r ibu ted fa s h ion a t ru n -t im e, a n d gu a ra n tee th a t n etwork pea k power con s t ra in ts a re n ot exceeded . Exper im en ts dem on s t ra te th a t PowerHerd ca n effect ively regu la te n etwork power con s u m pt ion , m eet in g pea k power con s t ra in ts with n egligib le n etwork per form a n ce pen a lty. Arm ed with PowerHerd , n etwork des ign ers ca n focu s on s ys tem per form a n ce a n d power op t im iza t ion for th e a vera ge ca s e ra th er th a n th e wors t ca s e, th u s m a kin g it pos s ib le to em ploy a m ore powerfu l in tercon n ect ion n etwork in th e s ys tem . BIOGRAPHY Li Shang is cu r ren t ly a gra du a te s tu den t a t Pr in ceton Un ivers ity’s Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g. He received h is B.E . a n d M.E. from Ts in gh u a Un ivers ity in 1997 a n d 1999 . Li Sh a n g’s res ea rch h a s focu s ed on s ys tem -level power a n a lys is a n d op t im iza t ion in d is t r ibu ted em bedded s ys tem s , s pecia lized in h a rdwa re/ s oftwa re co-s yn th es is , power a n a lys is a n d op t im iza t ion of recon figu ra b le devices a n d in tercon n ect ion n etworks . Cu r ren t ly, h is res ea rch is in th e a rea of power-a wa re in tercon n ect ion n etworks . He received Pr in ceton Un ivers ity’s Wa lla ce Mem or ia l Hon or ific Fellows h ip . He h a s won th e Bes t Pa per Awa rd a t PDCS’02 .


107


Des ign a n d Im plem en ta t ion of a Pa ra llel Proces s or IC for J ob Sh op Sch edu lin g

Ku a n -Hu n g Ch en , Tzi-Da r Ch iu eh Mem ber , IEEE, a n d Shi-Chung Chang Mem ber , IEEE,

Depa r tm en t of E lect r ica l En gin eer in g

Na t ion a l Ta iwa n Un ivers ity, Ta ipei, Ta iwa n 10617 Em a il: ch iu eh @cc.ee.n tu .edu .tw Tel: +886-2-23635251 ext . 511

Fa x: +886-2-23659042

Peter B. Lu h , Fellow, IEEE, Dept . of E lect r ica l a n d Com pu ter En gin eer in g

Un ivers ity of Con n ect icu t , S tor r s , Con n ect icu t 06269-2157 USA Em a il: lu h @en gr .u con n .edu

Ph on e: 860-486-5957 or 860-486-4821 Fa x: 860-486-5585 or 860-486-1273

ABSTRACT J ob s h op is a typ ica l en viron m en t for m a n u fa ctu r in g low-volu m e a n d h igh -va r iety d is crete pa r ts , wh ere pa r ts a re of va r iou s du e da tes , p r ior it ies a n d s equ en ces of p rodu ct ion opera t ion s . Good s ch edu lin g of wh en to do wh a t u s in g wh ich res ou rce is cr it ica l a n d ch a llen gin g for th e com pet it iven es s of job s h ops . Th e La gra n gia n rela xa t ion n eu ra l n etwork (LRNN) pres en ted by Lu h et a l. p rovides a n effect ive s olu t ion to th is p rob lem . To fu r th er s peed u p th e s ch edu lin g of la rge p rob lem s , th e pa ra llelis m of th e LRNN a pproa ch is exp loited in th is pa per for h a rdwa re im plem en ta t ion . A pa ra llel p roces s or ba s ed on th e SIMD a rch itectu re a n d it s a s s ocia ted in s t ru ct ion s et a re des ign ed . Th e a rch itectu re is im plem en ted in a s in gle-poly qu a dru p le-m eta l 0 .35-mm CMOS tech n ology. Tes t res u lt s s h ows th a t th e fa br ica ted ch ip a ch ieves 10 a n d 30 t im es s peed-u p wh en com pa red with s evera l com m ercia l DSP ch ips a n d a 600-MHz PC res pect ively. BIOGRAPHY Shi-Chung Chang r eceived h is B.S.E .E . degree from Na t ion a l Ta iwa n Un ivers ity, Ta iwa n , Repu blic of Ch in a , in 1979 , a n d h is M.S. a n d Ph .D. degrees in elect r ica l a n d s ys tem s en gin eer in g from th e Un ivers ity of Con n ect icu t , S tor r s , in 1983 a n d 1986 res pect ively. From 1979 to 1981 h e s erved a s a n En s ign in th e Ch in es e Na vy, Ta iwa n . He worked a s a tech n ica l in tern a t th e Pa cific Ga s a n d Elect r ic Co., Sa n Fra n cis co, in th e s u m m er of 1985 . Du r in g 1987 , h e wa s a m em ber of th e Tech n ica l S ta ff, decis ion s ys tem s s ect ion , ALPHATECH, In c., Bu r lin gton , MA. He h a s been with th e Elect r ica l En gin eer in g Depa r tm en t of Na t ion a l Ta iwa n Un ivers ity s in ce 1988 a n d wa s p rom oted to Profes s or in 1994 . Du r in g 2001-2002 , h e s erved a s th e Dea n of Stu den t Affa ir s a n d a Profes s or of E lect r ica l En gin eer in g, Na t ion a l Ch i Na n Un ivers ity, Pu -Li, Ta iwa n . He is a ls o join t ly a ppoin ted by th e Gra du a te In s t itu te of In du s t r ia l En gin eer in g a n d th e Gra du a te In s t itu te of Com m u n ica t ion En gin eer in g, Na t ion a l Ta iwa n Un ivers ity. His res ea rch in teres ts in clu de op t im iza t ion th eory a n d a lgor ith m s , p rodu ct ion s ch edu lin g a n d con t rol, h igh s peed n etworks , In tern et econ om ics a n d d is t r ibu ted decis ion m a kin g. He h a s been a p r in cipa l in ves t iga tor a n d con s u lta n t to m a n y in du s t ry a n d govern m en t fu n ded projects in th e a bove a rea s , a n d h a s pu b lis h ed m ore th a n 120 tech n ica l pa pers . He received , in 1996 , th e a wa rd


108

of ou ts ta n d in g a ch ievem en ts in Un ivers ity-In du s t ry Colla bora t ion by Min is t ry of Edu ca t ion for h is p ion eer in g a n d s u cces s fu l res ea rch colla bora t ion s with Ta iwa n s em icon du ctor in du s t ry on p rodu ct ion s ch edu lin g a n d con t rol. Dr . Ch a n g is a m em ber of E ta Ka ppa Nu a n d Ph i Ka ppa Ph i.


109

T12 - Tech n ica l Ses s ion 12 : Bioin form a t ics (III)

Ses s ion Ch a ir

Clive Bowm an

Director Popu la t ion Gen et ics , Gen et ics Res ea rch , Gen et ics Res ea rch , UK Tel: +44-1438-768095 Fa x: +44-1438-764231

Em a il: clive.e.bowm a n @gs k .com

BIOGRAPHY Clive Bowm a n C.Sta t FLS is Director Popu la t ion Gen et ics , Dis covery Gen et ics , Gen et ics Res ea rch a t Gla xoSm ith Klin e. For th e deca de p r ior to join in g Gla xoWellcom e in 1998 , Clive own ed a n d ra n s pecia lis t Clin ica l Res ea rch Orga n iza t ion s . Clive received h is MSc., in Biom etr ics from Rea d in g Un ivers ity, UK in 1985 u n der th e gu ida n ce of Prof. Roger Mea d s pecia lizin g in des ign . In 1993 h e beca m e a Fellow of Roya l Sta t is t ica l Society. He h a s led a va r iety of roles in da ta exp lora t ion , s ta t is t ics , QA, IT, ph a rm a cokin et ics a n d pu b lis h in g . For th e pa s t five yea rs , Clive a n d oth er GSK s cien t is t s h a ve been lea d in g th e wa y in th e u s e of h igh den s ity wh ole gen om e SNP m a ps in th e s ea rch for s u s cep t ib ility gen es a n d in ph a rm a cogen et ics .


110


Im pa ct of Gen et ic HAP Ma rkers to Ou tcom es in Pros pect ive Clin ica l Tr ia ls

Chuanbo Xu

Sen ior Director , Bioin form a t ics Gen a is s a n ce Ph a rm a ceu t ica ls , In c.

Tel: 203-786-3447 Fa x: 203-562-9377

Em a il: c.xu @gen a is s a n ce.com

ABSTRACT Gen et ics a s ba s is for m edicin e developm en t a n d pa t ien t ca re p rovis ion in gen era l h a s been a ccep ted a s th e b igges t ch a llen ge fa cin g toda y’s h ea lth ca re in du s t ry. With th e a dva n cem en t of b iotech n ology a n d in form a t ion tech n ologies , th e h u m a n s cien t ific s ociety h a s fin is h ed th e s equ en cin g a n d a s s em bly of th e com plete h u m a n gen om e. Th e n ext obviou s s tep will be th e in tegra t ion a n d u s a ge of th is in form a t ion in th e developm en t of bet ter d ia gn os t ics a n d th era peu t ics . Th e u n ders ta n d in g of th e gen et ic com pon en t in th e in terp la y of th e th era peu t ics a n d th e d is ea s e ou tcom e h a s p rom oted a ppropr ia tely th e d is covery res ea rch es on th e b iologica l m a rkers in th e d ivers e h u m a n gen et ic ba ckgrou n d in a s s ocia t ion with th e clin ica l ph en otypes . At Gen a is s a n ce, we h a ve s ta r ted by bu ild in g th e h a p lotype tech n ology p la t form u s in g h igh -th rou gh pu t gen om ic s equ en cin g a n d gen otyp in g m eth odologies . Th e polym orph is m a n d h a p lotype m a rkers a re s elected a n d s ta t is t ica l a s s ocia t ion s between th es e m a rkers a n d th e clin ica l en dpoin ts were s tu d ied in p la cebo-con t rolled clin ica l t r ia l s et t in gs . Th is p res en ta t ion will cover th e gen era l p roces s a n d th e s ta t is t ics of th e SNP a n d h a p lotype m a rker d is covery, gen e a n d m a rker s elect ion in s om e a s pects of clin ica l s tu d ies , clin ica l s u b ject gen otyp in g, a n d s ta t is t ica l a s s ocia t ion a n a lys is . BIOGRAPHY Ch u a n bo Xu is cu r ren t ly th e Sen ior Director of Bioin form a t ics a t Gen a is s a n ce Ph a rm a ceu t ica ls , In c. New Ha ven , Con n ect icu t . Pr ior to th is pos it ion , h e h a s been th e Director a n d As s ocia te Director a t Gen a is s a n ce. Before Gen a is s a n ce, h e h a s been a Bioin form a t ics Con s u lta n t for two a n d h a lf yea rs a t Gla xoWellcom e, In c., n ow a pa r t of Gla xoSm ith Klin e, in RTP, Nor th Ca rolin a . Before th a t , h e h a s been a Com pu ta t ion a l Scien t is t for th ree yea rs a t Pion eer Hi-Bred In tern a t ion a l, Des Moin es , Iowa , a n d n ow a s u bs id ia ry of Du Pon t Corp . Ch u a n bo Xu ’s edu ca t ion ba ckgrou n d covers a Veter in a ry d ip lom a from J ilin Agr icu tu ra l Un ivers ity of Ch in a a n d a Ph D in Im m u n ology from Ch in es e Aca dem y of Agr icu ltu ra l Scien ces , a n d a pos t -doctora l res ea rch exper ien ce of 3 yea rs a t Pa s teu r In s t itu te, Fra n ce. He a ls o h olds a DESS degree from Un ivers ity of Pa r is V in th e a rea of Com pu ter Applica t ion in Life Scien ces . His m a in exper t is e a n d in teres t a rea s cover b ioin form a t ics a n d ph a rm a cogen om ics a pp lica t ion s in d ru g d is covery a n d developm en t p roces s , gen om ic a n d clin ica l da ta m odelin g, da ta m a n a gem en t , rela t ion a l da ta ba s e des ign , m olecu la r a n d gen et ic da ta a n a lys is , m in in g, vis u a liza t ion a n d da ta qu a lity con t rol, a n d s oftwa re a pp lica t ion developm en t . He is th e a u th or a n d co-a u th or of a n u m ber of s cien t ific pu b lica t ion s a n d ga ve p res en ta t ion s a t a n u m ber of b iologica l a n d b ioin form a t ics rela ted con feren ces .


111


A n ovel wa y to fin d th e m os t d is cr im in a n t gen e s ets on Microa r ra y

Han-Yu Chuang and Che ng-Yan Kao

Depa r tm en t of CSIE, Na t ion a l Ta iwa n Un ivers ity, Ta ipei 106 , Ta iwa n . {r90002 , cyka o}@cs ie.n tu .edu .tw

ABSTRACT Microa r ra ys , a recen t tech n ology in exper im en ta l m olecu la r b iology, h a ve been u s ed to h elp th e developm en t of d ia gn os t ic tools a n d cla s s ifica t ion p la t form s in ca n cer res ea rch . Differen t a pproa ch es , in clu d in g u n iva r ia te a n d m u lt iva r ia te tech n iqu es , h a ve been developed to s elect p red ict ive gen es in a n expres s ion da ta s et for cla s s ifica t ion . Th e u n iva r ia te a pproa ch es m a y los e gen e-gen e cor rela ted rela t ion s s in ce th ey exa m in e on e gen e a t a t im e. Moreover , a s s u m pt ion s of h om ogen eity with in th e s a m e cla s s u s ed in th es e m eth ods often s u ffice for b in a ry or 3 -cla s s da ta s ets . Severa l m u lt iva r ia te a pproa ch es , wh ich iden t ifyin g gen es th a t join t ly d is cr im in a te between m u lt i-cla s s es of s a m ples , overcom e a bove d ra wba cks bu t m a y over fit to s om e k in d of ob ject ives by u s in g a pa r t icu la r cla s s ifier d irect ly a s cr iter ia for goodn es s of gen e s ets . Fu r th erm ore, s u ch s ys tem s con ta in m a n y pa ra m eter a d ju s tm en ts to get bet ter res u lt s . We propos ed a gen et ic a lgor ith m ba s ed a pproa ch , com bin in g u n iva r ia te a n d m u lt iva r ia te tech n iqu es , u s e Ga m m a tes t [Stefa n s s on et. a l., 1997] a n d Pea rs on cor rela t ion a s eva lu a t ion fu n ct ion s to fin d op t im a l gen e s ets with m in im u m s ize for s a m ple cla s s ifica t ion on gen e expres s ion da ta a u tom a t ica lly a n d u n b ia s ed . Ou r a pproa ch ca n be d ivided in to two s teps : (1 ) p reproces s in g by Th res h old Nu m ber of Mis cla s s ifica t ion (TNoM) a n d perm u ta t ion tes ts to filter ou t gen es with n on -in form a t ive pa t tern s between cla s s es , a n d (2 ) u s in g a m u lt i-ob ject ive gen et ic a lgor ith m to fin d s u bs ets of s ign ifica n t gen es der ived from s tep 1 with lower cor rela t ion with in gen e pa t tern s a n d h igh er cor rela t ion to cla s s es . Th e GA in Step 2 h a s two m a jor m ech a n is m s to h elp loca l a n d globa l s ea rch es , in clu d in g h eterogen eou s pa ir in g s elect ion (HpS) a n d fa m ily com pet it ion . Th e ob ject ive fu n ct ion con ta in s two pa r ts , wh ich m in im ize th e s u m of th es e two s cores : (1 ) Ga m m a tes t gives a da ta -der ived es t im a te for th e m ea n -s qu a red er ror of cla s s ifica t ion , bu t n ot a cla s s ifier a ctu a lly; (2 ) Pea rs on cor rela t ion is u s ed to get a gen e s ets with s m a ller s ize a n d com plem en t pa t tern s . We u s e th e cla s s ifica t ion a ccu ra cy of K-n ea res t n eigh bor cla s s ifier a n d lea ve-on e-ou t cros s -va lida t ion to eva lu a te ou r per form a n ce. In ou r p relim in a ry s tu dy for Colon ca n cer da ta s et , we get 56 gen es rem a in ed a fter th e filter in g s tep a n d 8 of th em to be th e fin a l p red ict ive s et . Th e cla s s ifica t ion a ccu ra cy is 95% wh en K = 3 a n d u s in g a m a jor ity ru le.

1 . Stefen s s on , A., Kon ca r , N., a n d J on es , A.J . (1997) A Note on th e Ga m m a Tes t . Neural Com put. Applic., 5 , 131-133 .

BIOGRAPHY Ch en g-Ya n Ka o wa s born in Ta ipei, Ta iwa n , 1948 . He received B.S. in m a th em a t ics from Na t ion a l Ta iwa n Un ivers ity, Ta ipei, Ta iwa n , in 1971 , a n d th e M.S. degree in com pu ter s cien ce in 1976 , th e M.S. degree in s ta t is t ics in 1978 , a n d th e Ph .D. degree in com pu ter s cien ce in 1981 , a ll from th e Un ivers ity of Wis con s in -Ma dis on . He worked for Ford Aeros pa ce, th e Un is ys Corpora t ion , a n d worked for Gen era l E lect r ic from 1980 to 1989 a t th e J oh n s on Spa ce Cen ter , NASA, Hou s ton , TX. He h a s been a p rofes s or with


112

th e Depa r tm en t of Com pu ter Scien ce a n d In form a t ion En gin eer in g, Na t ion a l Ta iwa n Un ivers ity s in ce 1990 . He h a s pu b lis h ed m ore th a n 40 tech n ica l pa pers in va r iou s jou rn a ls a n d in tern a t ion a l con feren ces . His res ea rch in teres ts in clu de b ioin form a t ics , b ioch ip , evolu t ion a ry com pu ta t ion , op t im iza t ion , a n d gr id com pu t in g. He h a s been th e p res iden t of Bioin form a t ics Society Ta iwa n s in ce 2000 .


113


A Novel Pa t tern Recogn it ion for Microa r ra y Da ta An a lys is

Huix iao Hong, Ph .D.

Ma n a ger , Bioin form a t ics La bora tory NCTR/ FDA, J effers on , AR

Tel: 870-543-7296 Fa x: 870-543-7382

Em a il: h h on g@n ctr .fda .gov

ABSTRACT DNA m icroa r ra y tech n ology en a b les in ves t iga t in g th e expres s ion of th ou s a n ds of gen es in a s in gle exper im en t . Accu ra te a n a lys is a n d m ea n in gfu l in terpreta t ion of m a s s ive in form a t ion from th is tech n ology pos e a u n iqu e ch a llen ge. Cla s s ifica t ion u s in g th e pa t tern recogn it ion m eth ods ca n be u s ed to p red ict d is ea s e type a n d / or s ta ge a n d ch em ica l-in du ced toxicity ba s ed on th e gen e expres s ion da ta from m icroa r ra y exper im en ts , a n d is p rom is in g for cor rela t ion of gen otype with ph en otype. Cla s s ifica t ion m odels a re developed in two s teps : con s t ru ct ion a n d va lida t ion . Mos t cla s s ifica t ion m odels ba s ed on m icroa r ra y da ta in th e litera tu re a re developed by fir s t s elect in g a s m a ll s u bs et of gen es from a m on g th e la rge s et of gen es on m icroa r ra y. Th e s a m e s u bs et of gen es is th en u s ed in both m odel developm en t a n d va lida t ion s teps , s u ch th a t er rors a s s ocia ted in gen e s elect ion a re n ot pa r t of va lida t ion . In th is p res en ta t ion , a n ovel cla s s ifica t ion m eth od , n a m ed Decis ion Fores t is p res en ted , wh ich com bin es th e gen e s elect ion a n d m odel con s t ru ct ion in to a s in gle s tep . Th e m eth od offers a n u m ber of a dva n ta ges over t ra d it ion a l cla s s ifica t ion a pproa ch es . More s pecifica lly, th e cros s -va lida t ion res u lt of Decis ion Fores t th a t in tegra tes gen e s elect ion with m odel developm en t p rovides bet ter in d ica t ion to th e qu a lity of a cla s s ifica t ion m odel. BIOGRAPHY Dr . Hu ixia o Hon g received h is Ph .D. in Com pu ta t ion a l Ch em is t ry from Na n jin g Un ivers ity in Ch in a in 1990 . Followin g pos tdoctora l res ea rch a t Ma xwell In s t itu te for Molecu la r Scien ces in Leeds Un ivers ity in U.K. from 1990 to 1992 , h e wa s a s s ocia te p rofes s or of com pu ta t ion a l ch em is t ry a t Na n jin g Un ivers ity in Ch in a from 1992 to 1995 . Dr Hon g join ed Dr . Miln e’s res ea rch grou p a t th e Na t ion a l Ca n cer In s t itu te a t Na t ion a l In s t itu tes of Hea lth a s a vis it in g s cien t is t in 1995 . In 1998 , h e m oved to Som itu m o Ch em ica l Co. Ltd . in J a pa n a s a res ea rch s cien t is t . In 2000 , h e join ed a n on -s ite IT con t ra ctor a t th e FDA’s NCTR to develop ch em oin form a t ics a pproa ch es for m a n a gin g a n d pred ict in g h orm on e-rela ted a n d en docr in e-d is ru p t in g com pou n ds . He th en beca m e Ma n a ger of th e Bioin form a t ics La bora tory to develop com pu ta t ion a l toxicology m eth ods a n d b ioin form a t ics a pproa ch es for gen om ic, p roteom ic a n d m eta bon om ic res ea rch a s well a s t ra d it ion a l toxicologica l s tu d ies a t NCTR. Dr . Hon g h a s pu b lis h ed over 50 res ea rch pa pers a n d h olds 3 US a n d J a pa n es e pa ten ts .


114

T13 - Tech n ica l Ses s ion 13 : C4I (III): Mu lt i-Service Com m u n ica t ion s

Ses s ion Ch a ir

Yih-Kang Mauric e Lin

Dis t r ict Ma n a ger AT&T

Tel: 732-420-2472 Fa x: 732-368-1774

Em a il: ym lin @a t t .com

BIOGRAPHY Yih -Ka n g Ma u r ice Lin received th e B.S. ph ys ics from Na t ion a l Cen t ra l Un ivers ity, Ta iwa n in 1974 , M.S. ph ys ics from Un ivers ity of Ka n s a s in 1979 , a n d M.S. in form a t ion & com pu ter s cien ce from Georgia Tech in 1980 a n d Ph .D. elect r ica l en gin eer in g from UCLA in 1988 . Dr . Lin is cu r ren t ly a Dis t r ict Ma n a ger a t AT&T La bs a n d res pon s ib le for cer t ifica t ion of h igh -s peed Eth ern et m etro s ervices a n d Eth ern et a cces s to AT&T da ta a n d IP n etworks . He is a ls o res pon s ib le for cer t ifyin g a cces s tech n ologies – s u ch a s DSL, VSAT - for a cces s to AT&T da ta pa cket n etworks . Pr ior to th is , h e wa s m a n a gin g th e ATM in tegra t ion tes t d is t r ict a n d res pon s ib le for iden t ifyin g a n d tes t in g em ergin g a cces s tech n ologies to AT&T loca l a n d lon g-d is ta n ce ATM n etworks . His d is t r ict a ls o p rovided with t im e to m a rket s ervice developm en t s u ppor t for AT&T La t in Am er ica a n d UNISITI (AT&T Ch in a join t ven tu re) to dep loy th e n etworks a n d la u n ch th e s ervices in a very s h or t t im e fra m e. Dr . Lin join ed AT&T Bell La bora tor ies in 1994 a s a m em ber of tech n ica l s ta ff a n d led a tes t tea m to cer t ify AT&T ATM n etwork a n d s ervices . From 1988 to 1994 , h e join ed Bellcore a s a m em ber of tech n ica l s ta ff a n d worked on va r iou s p rojects , in clu d in g fiber to th e h om e, SMDS a n d ATM. From 1980 to 1983 , h e worked for Gea rh a r t In du s t r ies in Da lla s , Texa s a s a s oftwa re en gin eer .


115


Network Con vergen ce

Margare t T. Chios i

Divis ion Ma n a ger AT&T Pa cket Network Cer t ifica t ion

m ch ios i@a t t .com 732 .420 .2660

ABSTRACT With th e telecom m u n ica t ion s in du s t ry colla ps in g, th e s u rvivors will be th e s ervice p roviders wh o ca n p rovide lega cy a n d n ew em ergin g s ervices in a cos t effect ive m a n n er . Two a rea s a re fu n da m en ta l in a ch ievin g th es e cos ts – colla ps in g th e m u lt itu de of n etworks on to on e com m on a rch itectu re/ n etwork a n d a u tom a t in g opera t ion s p roces s es for zero h u m a n tou ch . Wh ile th es e s ou n d very ba s ic, th e ch a llen ge is to ta ke th e m a n y ven dor p rodu cts , wh ich focu s on on ly on e pa r t icu la r s ervice a n d m a ke th e a rch itectu re a ppea r a s on e s ea m les s n etwork . Th e ch a llen ge is to ta ke th e m a n y ven dor n etwork m a n a gem en t s ys tem s a n d to fu lly a u tom a te from th e cu s tom er requ es t , wh eth er it is p rovis ion in g, b illin g or fa u lt m a n a gem en t , to th e a ppropr ia te com m a n ds execu ted a t th e down s t rea m equ ipm en t . Th is ta lk will go th rou gh th es e con cep ts a n d th e ch a llen ges to a ch ieve th es e con cep ts . BIOGRAPHY Ma rga ret Ch ios i, Pa cket Services Cer t ifica t ion Divis ion Hea d , h a s been in th e da ta com m u n ica t ion s wor ld for 25+ yea rs . Her exper ien ce h a s ra n ged from dep loym en t of em ergin g n etwork tech n ologies for n ew da ta s ervices , to developm en t of da ta n etwork in g equ ipm en t , to s t ra tegic d irect ion for da ta s ervices a n d produ cts . Da ta exper ien ce h a s ra n ged from IP/ VPNs to FR/ ATM to SNA/ X.25 . Sh e cu r ren t ly lea ds a tech n ica l tea m res pon s ib le for cer t ifica t ion a n d dep loym en t of a ll th e AT&T pa cket n etwork s ervices – FR, ATM, IP. Th es e s ervices a ccou n t for m ore th a n 50% of AT&T’s bu s in es s reven u es (over $4B) with th e oth er reven u es com in g from pr iva te lin e s ervices . Ma rga ret h a s received h er m a s ters / ba ch elors in Com pu ter Scien ce from Pu rdu e Un ivers ity.


116


Fu tu re Evolu t ion in Loca l Acces s Tech n ology a n d Teleph on y Services

Irwin Ge rs zbe rg

Divis ion Ma n a ger AT&T Loca l Network Acces s Tech n ology

180 Pa rk Aven u e Bu ild in g 104 Room 3A37

Florh a m Pa rk , NJ 07932-0971 Voice: 1 (973) 236-6930

Em a il: irwin @a t t .com

BIOGRAPHY Irwin Gers zberg is Divis ion Ma n a ger of th e Adva n ced Loca l Network Acces s Tech n ology Orga n iza t ion for AT&T Loca l Services in Florh a m Pa rk , NJ . His orga n iza t ion is res pon s ib le for a ll “La s t Mile” Acces s Tech n ologies for th e AT&T Loca l Services Network . He h olds a Ba ch elor ’s degree in Elect r ica l En gin eer in g a n d a Ma s ter ’s in Com pu ter Scien ce from NJ IT a n d Steven s In s t itu te of Tech n ology. He join ed th e AT&T Bell Sys tem in 1978 . Wh ile a t Bell La bora tor ies , h e m a n a ged la rge s oftwa re p rojects for th e RBOC's in a dva n ced opera t ion s a n d tes t in g of th e loca l exch a n ge n etwork . In 1985 , h e s pea rh ea ded on e of AT&T's fir s t Speech Res pon s e/ Voice Recogn it ion Tr ia ls with th e RBOC’s . After join in g AT&T’s Wireles s u n it in 1989 , h e wa s res pon s ib le for th e developm en t of n u m erou s a dva n ced wireles s tech n ology s ervices . He h olds over 70 Pa ten ts on Loca l Acces s Tech n ology cover in g DSL, Voice over DSL, IP, Ca b le teleph on y, Broa dba n d Wireles s , CD qu a lity IP teleph on y & a va s t a r ra y of em ergin g Broa dba n d in fra s t ru ctu re a n d s ervices with th e Un ited Sta tes Pa ten t office. Th es e con t r ibu t ion s ea rn ed h im AT&T’s Scien ce a n d Tech n ology Meda l in 2001 . In Febru a ry of 2002 , h e wa s a wa rded “New J ers ey In ven tor of th e Yea r ” by th e Sta te of N.J . a n d in du cted in to th e N.J . In ven tors h a ll of con gres s for h is in n ova t ion s a n d con t r ibu t ion s to s cien ce a n d tech n ology in th e telecom m u n ica t ion s in du s t ry. Irwin is qu oted a s a n in du s t ry exper t a n d vis ion a ry in n u m erou s teleph on y a r t icles in th e Wa ll S t reet J ou rn a l, News week , Sta r ledger , Da ily Record , Hom e News , Teleph on y Ma ga zin e, etc. a n d h a s p rovided tes t im on y a t n u m erou s FCC Hea r in gs on telecom m u n ica t ion policy. He is a m em ber of th e NJ Tech n ology Cou n s el, As s ocia t ion of Pu b lic-Sa fety Com m u n ica t ion Officia ls , Society of Ca b le Telecom m u n ica t ion s En gin eers , a n d IEEE. He is a lifet im e res iden t of New J ers ey a n d lives in Ken da ll Pa rk with h is wife Sh er ry a n d th eir two ch ild ren .


117


Au ton om ic Ma n a gem en t of Mu lt i-s ervice Com pu t in g Ut ilit ies

Liana L. Fong

T. J . Wa ts on Res ea rch Cen ter IBM Corp .

P. O. Box 704 York town Heigh ts , NY 10985

(914)784-7269 em a il: llfon g@u s .ibm .com

ABSTRACT Com pu t in g u t ility or u t ility com pu t in g is con s idered to be th e em ergin g s ervice m odel for th e in tern et a n d e-bu s in es s . Un der th is m odel, cu s tom ers u s e s ys tem in fra s t ru ctu re a n d a s s ocia ted res ou rces s u ch a s n etwork ba n dwid th a n d proces s or cycles a s “ u t ilit ies ” s im ila r to teleph on y a n d elect r icity. Th e s ervice orga n iza t ion s often offer m u lt ip le s ervice p la n s , a n d in term will s erve a n d b ill cu s tom ers a ccord in g to s ervices th ey s u bs cr ibe to. Ma n a gem en t of s u ch com pu t in g u t ilit ies is very com plex du e to th e n eeds in : m on itor in g a n d en forcem en t of s ervice qu a lity ba s ed on cu s tom er s ervice p la n s , a n d con figu ra t ion s of va r iet ies of h eterogen eou s com pu t in g res ou rces . In pa r t icu la r , m os t of th e u n der lyin g s ys tem in fra s t ru ctu res of com pu t in g u t ilit ies con s is t of a n a r ra y of n etwork devices in clu d in g s witch es , rou ters , firewa ll, loa d ba la n cers . Th e ta s ks to es ta b lis h s pecific n etwork con n ect ivity a n d a cces s requ ired by bu s in es s policies a n d s ecu r ity ru les ca n be da u n t in g for a dm in is t ra tors . Th u s , it is es s en t ia l th a t com pu t in g u t ilit ies a re bu ilt with a u ton om ic m a n a gem en t ca pa b ility s u ch th a t th es e s ys tem s ca n be s elf-op t im izin g, s elf-con figu r in g, s elf-recovery, a n d s elf-p rotect in g, s im ila r to th e a u ton om ic ca pa b ility of h u m a n n ervou s s ys tem in res pon s e to extern a l s t im u li. Moreover , in d ividu a l u t ility res ou rces s u ch th a t n etwork devices wou ld even tu a lly h a ve bu ild -in a u ton om ic m a n a gem en t ca pa b ilit ies . BIOGRAPHY Lia n a L. Fon g join ed IBM T. J . Wa ts on Res ea rch Cen ter in 1985 a s a res ea rch s ta ff. Her res ea rch a ct ivit ies h a ve been in th e a rea s of opera t in g s ys tem s t ru ctu res , s ys tem m a n a gem en t a n d per form a n ce eva lu a t ion for com pu ter a rch itectu res ra n gin g from m a in fra m e, to works ta t ion , a n d to very la rge n etwork of s ys tem s for s cien t ific h igh per form a n ce com pu t in g. In a dd it ion to h er res ea rch a ct ivit ies , Lia n a a ls o in volves in tech n ology t ra n s fer to IBM produ ct d ivis ion s , a n d ca r r ies ou t p roof of con cep t en ga gem en ts with IBM la rge cu s tom er a ccou n ts . In recen t ly yea rs , Lia n a h a s con cen t ra ted on bu ild in g tech n ologies rela ted “on dem a n d” a n d “ a u ton om ic” com pu t in g in it ia t ives . Sh e wa s on e of th e lea d developers for Ocea n o, a n IBM fir s t res ea rch p rototype th a t s u ppor ted SLA ba s ed a u to-provis ion in g of n etwork a n d s ervers in m u lt i-s ervice com pu t in g fa rm s . Sh e h a s a ls o worked clos ely with IBM Globa l Services on e-bu s in es s tech n ologies for web h os t in g da ta cen ters . Her cu r ren t ly res ea rch focu s is on dem a n d res ou rce s ch edu lin g a n d a u to-provis ion in g.


118


Network ba s ed VPN Services – MPLS VPN

Luyuan Fang

Pr in cipa l Tech n ica l S ta ff Mem ber

AT&T La bs . Tel: 732 420 1921

Em a il: lu yu a n fa n g@a t t .com

ABSTRACT Wide Area Network (WAN) s ervice m a rket h a s s een evolu t ion from lega cy da ta s ervices (Pr iva te Lin e, Fra m e Rela y a n d ATM) to th e n ext gen era t ion IP ba s ed VPN s ervices in th e recen t yea rs . Ma n y Service Providers (SP) a rou n d th e wor ld h a ve been dep loyin g MPLS tech n ology in th eir n etworks s o th a t th ey ca n offer n etwork ba s ed IP VPN to bu s in es s es . With MPLS en a b led n etwork , Service Providers a re a b le to offer cos t effect ive a n d con verged VPN s ervices th a t s u ppor t bu s in es s ’s n eeds for in t ra n et , r em ote a cces s a n d ext ra n et a s well a s da ta , voice a n d video a pp lica t ion s . MPLS IP VPN will be on e of h igh growth s ervices in th e com m u n ica t ion s m a rket in th e n ext five yea rs .

Th is p res en ta t ion will fir s t exa m in e VPN im plem en ta t ion a n d look in to th e VPN m a rket t ren d . With a n in t rodu ct ion of MPLS tech n ology, th is p res en ta t ion will p rovide overview of h ow MPLS tech n ology works in IP n etwork , wh a t role of MPLS p la ys in con vergen ce a n d wh a t ben efit s of MPLS IP VPN ca n be b rou gh t to bu s in es s es . Fin a lly th e p res en ta t ion con clu des th a t MPLS is on e of key n ext gen era t ion tech n ologies th a t en a b le n etwork con vergen ce a n d n etwork ba s ed on VPN s ervices ba s ed on MPLS a n d IP will s ee wide a dopt ion by bu s in es s es in th e n ea r fu tu re. BIOGRAPHY Lu yu a n Fa n g is a Pr in cipa l Tech n ica l S ta ff Mem ber in th e Globa l IP Network Arch itectu re Des ign orga n iza t ion a t AT&T La bs . Sh e is d irect ly res pon s ib le for th e des ign a n d en gin eer in g of MPLS tech n ology in th e AT&T IP ba ckbon e. Dr . Fa n g is th e lea d a rch itect for s evera l AT&T MPLS IP VPN produ ct dep loym en ts , a n d p la ys a key role in tech n ica l rea liza t ion of MPLS IP VPN s ervice fea tu res in th e AT&T IP n etwork . In a dd it ion to h er MPLS VPN a ct ivit ies , Dr . Fa n g is in volved in eva lu a t in g forwa rd-look in g n etwork tech n ologies a n d equ ipm en t ca pa b ilit ies to s u ppor t em ergin g s ervices . Pr ior to h er cu r ren t pos it ion , Dr . Fa n g wa s res pon s ib le for th e des ign a n d dep loym en t of AT&T In tern a t ion a l Fra m e Rela y Services , in clu d in g globa l ATM-Fra m e Rela y In terwork in g. Pr ior to join in g AT&T, Dr . Fa n g h eld va r iou s res ea rch pos it ion s in Ar t ificia l In telligen ce a n d da ta n etwork in g in Tels t ra , Nor tel, a n d Ra ca l Da ta com . Dr . Fa n g h a s exten s ive exper ien ces in MPLS tech n ology a n d IP/ da ta n etwork in g. Sh e is very a ct ive in IETF, wh ere s h e is cu r ren t ly co-a u th or in g s evera l In tern et Dra fts a n d RFCs in th e MPLS, PPVPN a n d Tra ffic En gin eer in g Work in g Grou ps . Sh e is a frequ en t ly in vited s pea ker a t lea d in g in tern a t ion a l con feren ces on MPLS tech n ology a n d VPN dep loym en t . Sh e h a s given s evera l tu tor ia ls on MPLS a n d VPN tech n ologies in IEEE con feren ces a n d oth er MPLS even ts , a n d h a s pu b lis h ed m ore th a n 40 tech n ica l pa pers .


119

Dr . Fa n g h olds a Ph .D. in Com pu ter Scien ce from th e Flin ders Un ivers ity of Sou th Au s t ra lia , a n M.S. in Com pu ter Scien ce from Br igh a m You n g Un ivers ity, Uta h , a n d a B.S. in Ph ys ics from J ia n gxi Un ivers ity, Ch in a .


120

T14 - Tech n ica l Ses s ion 14 : C4I (IV): In form a t ion a n d Kn owledge Ma n a gem en t

Ses s ion Ch a ir

Zon-Yin Shae

IBM T. J . Wa ts on Res ea rch Cen ter BIOGRAPHY Zon -Yin Sh a e is a t th e IBM Wa ts on Res ea rch Cen ter , wh ere h e works in th e a rea of VoIP, SIP, m u lt im edia s t rea m in g, m edia en a b lin g e-bu s in es s a pp lica t ion s a n d th e u s e of m u lt im edia to b r idge ph ys ica l a n d vir tu a l en viron m en ts . He led IBM m u lt im edia s t rea m in g project u s ed for th e At la n ta Olym pic Ga m e. He is cu r ren t ly work in g on th e VoIP/ SIP con verged en terpr is e a pp lica t ion s , in fra s t ru ctu re a n d s ervices . Dr . Sh a e received th e B.S. a n d M.S. degrees in elect ron ic en gin eer in g from th e Na t ion a l Ch ia o-Tu n g Un ivers ity, Ta iwa n , 1976 a n d 1978 res pect ively, a n d th e Ph .D. degree in elect r ica l en gin eer in g from th e Un ivers ity of Pen n s ylva n ia , Ph ila delph ia , USA, 1989 . From 1980 to 1984 , before h e pu rs u ed h is Ph .D. degree, h e worked a s a n en gin eer in th e a rea s of com m u n ica t ion s ys tem a n d m icroprogra m m in g CPU des ign for s ign a l p roces s in g. S in ce Ma rch 1989 , h e h a s been with IBM Wa ts on Res ea rch Cen ter , New York . Dr . Sh a e h a s pu b lis h ed ten s of tech n ica l pa pers a n d a pp lied ten s U.S. pa ten ts . He h a s received va r iou s a wa rds from IBM Wa ts on Res ea rch Cen ter for h is con t r ibu t ion s in th e a rea of m u lt im edia com m u n ica t ion .


121


On Vis u a l S im ila r ity Ba s ed 3D Model Ret r ieva l

Ming Ouhyoung

Profes s or , Dept . of Com pu ter Scien ce a n d In form a t ion En gin eer in g, Na t ion a l Ta iwa n Un ivers ity

Tel: 732-216-4517 , (886)23625336 Ext . 421 Em a il: m in g@cs ie.n tu .edu .tw

ABSTRACT A la rge n u m ber of 3D m odels a re crea ted a n d a va ila b le on th e Web, s in ce m ore a n d m ore 3D m odellin g a n d d igit izin g tools a re developed for ever in crea s in g a pp lica t ion s . Th e tech n iqu es for con ten t -ba s ed 3D m odel ret r ieva l th en becom e n eces s a ry. In th is pa per , a vis u a l s im ila r ity-ba s ed 3D m odel ret r ieva l s ys tem is p ropos ed . Th is a pproa ch m ea s u res th e s im ila r ity a m on g 3D m odels by vis u a l s im ila r ity, a n d th e m a in idea is th a t if two 3D m odels a re s im ila r , th ey a ls o look s im ila r from a ll viewin g a n gles . Th erefore, on e h u n dred or th ogon a l p roject ion s of a n ob ject , exclu d in g s ym m etry, a re en coded both by Zern ike m om en ts a n d Fou r ier des cr ip tors a s fea tu res for la ter ret r ieva l. Th e vis u a l s im ila r ity-ba s ed a pproa ch is robu s t a ga in s t s im ila r ity t ra n s form a t ion , n ois e, m odel degen era cy etc., a n d p rovides 42%, 94% a n d 25% bet ter per form a n ce (p recis ion -reca ll eva lu a t ion d ia gra m ) th a n th ree oth er com pet in g a pproa ch es : (1 )th e s ph er ica l h a rm on ics a pproa ch developed by Fu n kh ou s er et a l., (2 )th e MPEG-7 Sh a pe 3D des cr ip tors , a n d (3 )th e MPEG-7 Mu lt ip le View Des cr ip tor . Th e p ropos ed s ys tem is on th e Web for p ra ct ica l t r ia l u s e ( h t tp :/ / 3d .cs ie.n tu .edu .tw), a n d th e da ta ba s e con ta in s m ore th a n 10 ,000 pu b licly a va ila b le 3D m odels collected from WWW pa ges . Fu r th erm ore, a u s er fr ien d ly in ter fa ce is p rovided to ret r ieve 3D m odels by d ra win g 2D s h a pes . Th e ret r ieva l is fa s t en ou gh on a s erver with Pen t iu m IV 2 .4GHz CPU, a n d it ta kes a bou t 2 s econ ds a n d 0 .1 s econ ds for qu eryin g d irect ly by a 3D m odel a n d by h a n d dra wn 2D s h a pes , res pect ively. BIOGRAPHY Min g Ou h you n g received th e BS a n d MS degree in elect r ica l en gin eer in g from th e Na t ion a l Ta iwa n Un ivers ity, Ta ipei, in 1981 a n d 1985 , res pect ively. He received th e Ph .D degree in com pu ter s cien ce from th e u n ivers ity of Nor th Ca rolin a a t Ch a pel Hill in J a n ., 1990 . He wa s a m em ber of th e tech n ica l s ta ff a t AT&T Bell La bora tor ies , Midd le-town , du r in g 1990 a n d 1991 . Sin ce Au gu s t 1991 , h e h a s been a n a s s ocia te p rofes s or in th e depa r tm en t of Com pu ter Scien ce a n d In form a t ion En gin eer in g, Na t ion a l Ta iwa n Un ivers ity. Th en s in ce Au gu s t 1995 , h e beca m e a p rofes s or . He wa s th e Director of th e Cen ter of Excellen ce for Res ea rch in Com pu ter Sys tem s , College of En gin eer in g, from Au gu s t 1998 to J u ly 2000 , a n d wa s th e Ch a irm a n of th e Dept . of CSIE from Au gu s t 2000 to J u ly 2002 . He h a s pu b lis h ed over 100 tech n ica l pa pers on com pu ter gra ph ics , vir tu a l rea lity, a n d m u lt im edia s ys tem s . He is a m em ber of ACM a n d IEEE. Min g is cu r ren t ly on s a bba t ica l lea ve, a n d is a vis it in g fellow a t th e Dept . of Com pu ter Scien ce, Pr in ceton Un ivers ity. He colla bora tes with Profes s or Th om a s Fu n kh ou s er in Gra ph ics a n d Com pu ta t ion a l Geom etry Grou p a t Pr in ceton .


122


E-Com m erce Va lu e Ch a in Bu s in es s Tra n s form a t ion

J ih -Shyr Yih

Ma n a ger , E-Com m erce Arch itectu re IBM Wa ts on Res ea rch

Tel: 914-784-7866 Em a il: jyih @u s .ibm .com

ABSTRACT Th is ta lk covers exper ien ces lea rn ed in th e e-com m erce va lu e ch a in con s t ru ct ion s , with res pect to bu s in es s p roces s m a n a gem en t a n d va r iou s da ta feed in tegra t ion s . In a dd it ion to com m erce s tores , we will a ddres s fu lfillm en t , wh ich s u ppor ts from qu ote to ca s h . We will d is cu s s in form a t ion in tegra t ion m eth odology u s ed in th e cu r ren t va lu e ch a in s , a n d p rob lem oppor tu n it ies in a rea s s u ch a s da ta qu a lity, du p lica t ion , p ropa ga t ion dela y, t ra n s form a t ion , th e h a n d lin g of la rge docu m en ts , a n d s o on . Th e ta lk p res en ts s olu t ion s u s in g a Webs ph ere Bu s in es s In tegra t ion clu s ter in g tech n iqu e a n d en h a n cem en ts in WBI a da p ters for a ct ive pers is ten t s t rea m in g da ta opera t ion s . A cu t -th rou gh m eth od u s in g a "dou ble da ta s ch em a a n n ota t ion " tech n iqu e is to be d is cu s s ed on h ow da ta is h a n d led a n d m a n ipu la ted a m on gs t a pp lica t ion s , opera t ion a l da ta s tore, a n d colla bora t ion b rokers . BIOGRAPHY Dr . J ih -Sh yr Yih is n a t ive to Ta iwa n , received edu ca t ion s in US with doctora l degree from U. Mich iga n , 1990 , h a s a fterwa rd worked in IBM Wa ts on Res ea rch , a n d is cu r ren t ly m a n a gin g th e e-com m erce a rch itectu re dep t . He h a s ta ken on a s s ign m en ts to IBM divis ion s , for in tern et grou pwa re developm en t in Wh ite Pla in s , a n d for ba n k in g s olu t ion developm en t in Copen h a gen . Dr . Yih con du cts ba s ic tech n ology res ea rch a s well a s en ga ges in com m ercia l com m erce s olu t ion s a n d IBM’s own va lu e ch a in s t ra n s form a t ion . He is m os t in teres ted in work in g on rea l wor ld bu s in es s p rob lem s a n d provid in g feedba cks for p rodu ct developm en t .


123


Pr iva cy Protect ion on In form a t ion Ma n a gem en t

Xuan Liu

IBM T.J . Wa ts on Res ea rch Cen ter Tel: 914-245-9270 Fa x: 914-784-6032

Em a il: xu a n liu @u s .ibm .com

ABSTRACT Th e em ergen ce of n ew tech n ology on in form a t ion ca p tu r in g, in tegra t ion , a n a lys is , a n d d is s em in a t ion en a b les m ore in form a t ion s h a r in g a n d u s a ge. However , it a ls o ca u s es s ign ifica n t con cern s for in form a t ion a bu s e. Un les s a ddres s ed ea r ly in th e des ign , s ecu r ity a n d pr iva cy ca n be a s er iou s obs ta cle to th e ra p id a dopt ion to th os e n ew tech n ologies . Iden t ifyin g n ew ch a llen ges a n d develop in g tech n ology on s ecu r ity a n d pr iva cy to crea te on -dem a n d a s s u ra n ce is cr it ica l. In th is ta lk , I will d is cu s s th e p rob lem s of p r iva cy p rotect ion for in form a t ion s h a r in g, review s om e exis t in g p r iva cy tech n ologies , a n d iden t ify n ew ch a llen ges th a t n eed to be a ddres s ed to en a b le n ew in form a t ion in tegra t ion in fra s t ru ctu re. BIOGRAPHY Dr . Xu a n Liu is a res ea rch s ta ff m em ber a t IBM T.J . Wa ts on Res ea rch Cen ter . Sh e received h er Ph D in Com pu ter Scien ce from Un ivers ity Of Min n es ota , Min n ea polis . Her cu r ren t res ea rch in teres ts in clu de p r iva cy tech n ologies for in form a t ion s h a r in g a n d bu s in es s p roces s , XML tech n ologies , loca t ion -ba s ed s ervices , da ta m in in g, a n d s pa t ia l da ta ba s es . Sh e h a s pu b lis h ed m a n y pa pers in refer red jou rn a ls a n d in tern a t ion a l con feren ces . On e of h er pa pers p res en ted a t s ixth in tern a t ion a l s ym pos iu m of ACMGIS wa s a m on g th e bes t pa pers . Her res ea rch work h a s res u lted in to five pa ten ts filed , a n d a ls o been in corpora ted in to IBM produ cts , or relea s ed a s IBM Web s ervices toolk it on a lph a works . Dr . Liu h a s been in vited to review pa pers for va r iou s in tern a t ion a l jou rn a ls a n d con feren ces a n d in vited to give p res en ta t ion s on va r iou s con feren ces , u n ivers it ies a n d corpora t ion s . Sh e h a s s erved a s a p rogra m com m it tee m em ber for m a n y in tern a t ion a l con feren ces . Sh e is a m em ber of IEEE a n d ACM.


124


From In form a t ion to Bu s in es s Proces s Ma n a gem en t

Sh ih-Ping Liou, Ph .D.

Progra m Ma n a ger Siem en s Corpora te Res ea rch

Tel: 609-734-6514 Fa x: 609-734-6565

Em a il: Sh ih -Pin g.Liou @s iem en s .com

ABSTRACT In form a t ion m a n a gem en t is th e m ea n s by wh ich a n orga n iza t ion m a xim ize th e efficien cy with wh ich it p la n s , collects , orga n izes , u s es , con t rols , d is s em in a tes a n d d is pos es in form a t ion a n d th rou gh wh ich it en s u res th a t th e va lu e of in form a t ion is iden t ified a n d exp loited to th e fu ll exten t . However , th e t ru e ben efit s of a n in form a t ion lifecycle m a n a gem en t s ys tem ca n n ot be rea lized with ou t im plem en t in g a pp lica t ion s a n d workflows th a t p rovide th e a cces s to ea ch in form a t ion s ou rce. Both a pp lica t ion s a n d workflows will becom e u n m a n a gea b le if on e does n ot m a n a ge th e bu s in es s p roces s es beh in d th em . In th is ta lk , we will fir s t p res en t th e efficien cy a n d th e effect iven es s p rob lem s a s s ocia ted with m os t in form a t ion s ys tem s toda y a n d h ow we ca n res olve s u ch p rob lem s by redes ign in g a n ew en terpr is e in form a t ion a rch itectu re a n d im plem en t in g a n ew m idd lewa re la yer . BIOGRAPHY Sh ih -Pin g Liou wa s born in Ta in a n , Ta iwa n , Repu blic of Ch in a , in 1961 a n d gra du a ted in in form a t ion en gin eer in g from Na t ion a l Ta iwa n Un ivers ity in 1983 . He received th e M.S. a n d Ph .D. degree in com pu ter s cien ce a n d en gin eer in g from th e Un ivers ity of Mich iga n , An n Arbor , in 1986 a n d 1990 . From Sep tem ber 1990 to Novem ber 1992 , h e wa s a p roject en gin eer in Zexel Tech n ologies , In c., develop in g in -veh icle n a viga t ion s ys tem s . In 1992 , Dr . Liou join t S iem en s Corpora te Res ea rch , Pr in ceton , New J ers ey, wh ere h e is cu r ren t ly a p rogra m m a n a ger , res pon s ib le for th e res ea rch a n d developm en t of tech n ology a s well a s p roces s m eth odology rela ted to in form a t ion lifecycle m a n a gem en t . His exper ien ce s prea ds a cros s a wide ra n ge of bu s in es s a n d tech n ology a rea s , in clu d in g s t ra tegic a llia n ce, bu s in es s developm en t , qu a lity im provem en t , s ix s igm a , p rogra m / project m a n a gem en t , in form a t ion a rch itectu re, n etwork p rotocols , qu a lity of s ervice, m u lt im edia m es s a gin g a n d colla bora t ion , m u lt im edia s u m m a ry gen era t ion , m u lt im edia in dexin g/ ret r ieva l, m edica l im a gin g, 3D vis u a liza t ion , d is t r ibu ted com pu t in g, a n d com pu ter vis ion . Dr . Liou h a s pu b lis h ed in va r iou s jou rn a ls a n d con feren ce p roceed in gs a n d is a m em ber of th e ACM a n d IEEE. He h olds s ix US pa ten ts with m a n y m ore u n der review a n d h a s pu b lis h ed m ore th a n 30 pa pers on lea d in g jou rn a ls a n d con feren ces in a wide ra n ge of bu s in es s a n d tech n ology fields . He a ls o s erves on th e Editor ia l Boa rd of Ma ch in e Vis ion a n d Applica t ion s .


125

T15 - Tech n ica l Ses s ion 15 : Sys tem -on -Ch ip (IV)

Ses s ion Ch a ir

Mic hae l S . Hs iao

As s ocia te Profes s or Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g

Virgin ia Tech Tel: 540-231-9254 Fa x: 540-231-3362

Em a il: m h s ia o@vt .edu

BIOGRAPHY Mich a el S . Hs ia o received th e B.S. in Com pu ter En gin eer in g with h igh es t h on ors from th e Un ivers ity of Illin ois a t Urba n a -Ch a m pa ign in 1992 , a n d M.S. a n d Ph .D. in Elect r ica l En gin eer in g in 1993 a n d 1997 , res pect ively, from th e s a m e u n ivers ity. Du r in g h is s tu d ies , h e wa s recip ien t of th e Digita l Equ ipm en t Corp . Fellows h ip , McDon n ell Dou gla s Sch ola rs h ip , a n d Sem icon du ctor Res ea rch Corp . Res ea rch As s is ta n ts h ip . Between 1997 a n d 2001 , Dr . Hs ia o wa s a n As s is ta n t Profes s or in th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g a t Ru tgers Un ivers ity. S in ce 2001 , h e h a s been a n As s ocia te Profes s or in th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g a t Virgin ia Tech . He wa s a vis it in g s cien t is t a t NEC USA in Pr in ceton , NJ , du r in g th e s u m m er of 1997 , a n d h e wa s a vis it in g fa cu lty a t In tel Corpora t ion in th e s u m m er of 2002 . Mich a el is a recip ien t of th e Na t ion a l Scien ce Fou n da t ion CAREER Awa rd , a n d h e h a s pu b lis h ed m ore th a n 80 refereed jou rn a l a n d con feren ce pa pers . His cu r ren t res ea rch focu s es on SOC tes t in g, ver ifica t ion , d ia gn os is , a n d power m a n a gem en t .


126


LOW-COMPLEXITY/ HIGH-SPEED FORWARD ERROR CORRECTION ARCHITECTURE FOR OPTICAL COMMUNICATIONS

Hanho Le e

Depa r tm en t of E lect r ica l & Com pu ter En gin eer in g

371 Fa ir field Roa d Un it 1157 Un ivers ity of Con n ect icu t , S tor r s , CT 06269-1157

Tel: (860) 486-2192 Fa x: (860) 486-2447

Em a il: h a n h o.lee@u con n .edu

ABSTRACT Th e u s e of Forwa rd Er ror Cor rect ion (FEC) in op t ica l com m u n ica t ion s wa s p ion eered for s u bm a r in e s ys tem s wh ere detect ion a n d cor rect ion of er rors wa s cr it ica l for t ra n s m is s ion over very lon g h a u l n etworks . Ou t of m a n y er ror cor rect ion codes , Reed-Solom on (RS) codes h a ve been widely u s ed in a va r iety of com m u n ica t ion s ys tem s s u ch a s s pa ce com m u n ica t ion lin k , d igita l s u bs cr iber loops , a n d wireles s s ys tem s a s well a s in n etwork in g com m u n ica t ion s . However , a s da ta ra tes rea ch 40 Gb/ s a n d beyon d , th e power con s u m pt ion a n d com plexity of FEC devices a re th e m a in ba r r ier to in tegra te th em in to op t ica l com m u n ica t ion s ys tem s a t a low cos t . We pres en t th e des ign a n d im plem en ta t ion of low-com plexity/ h igh -s peed FEC a rch itectu re for h igh -s peed fiber op t ic com m u n ica t ion s ys tem s , a n d es pecia lly p res en t th e key idea s a pp lied to th e des ign of RS decoder b locks for a ch ievin g h igh th rou gh pu t a n d redu cin g com plexity. BIOGRAPHY Dr . Ha n h o Lee received Ph .D. a n d M.S. degrees , both in Elect r ica l & Com pu ter En gin eer in g, from th e Un ivers ity of Min n es ota , Min n ea polis , in 2000 a n d 1996 res pect ively, a n d a B.S. degree in Elect ron ics En gin eer in g from Ch u n gbu k Na t ion a l Un ivers ity, S . Korea , in 1993 . In 1999 , h e wa s a Res ea rch Con s u lta n t a t Lu cen t Tech n ologies , Bell La bs , Holm del. From Apr il 2000 to Au gu s t 2002 , h e wa s a Mem ber of Tech n ica l S ta ff a t th e Lu cen t Tech n ologies (Bell La bs In n ova t ion s ), Allen town , wh ere h e wa s res pon s ib le for th e developm en t of h igh -per form a n ce d igita l s ign a l p roces s or a rch itectu re for n ext -gen era t ion wireles s com m u n ica t ion s ys tem s . S in ce Au gu s t 2002 , h e is with th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g, Un ivers ity of Con n ect icu t , wh ere h e is p res en t ly a n As s is ta n t Profes s or . His res ea rch in teres ts in clu de th e d igita l VLSI circu it s a n d s ys tem s des ign for com m u n ica t ion s a n d com pu ters , Sys tem -on -a -Ch ip (SoC) des ign , a n d VLSI s ign a l p roces s in g.


127


Tes t in g High -Frequ en cy Ser ia l Com m u n ica t ion In ter fa ces in th e SoCs

J ie n-Chung Lo

Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g

4 Ea s t Alu m n i Ave. Un ivers ity of Rh ode Is la n d

Kin gs ton , RI 02881 USA

Tel: (401) 874-2996 Fa x: (401) 782-6422

Em a il: [email protected] r i.edu

ABSTRACT As poin ted ou t in th e In tern a t ion a l Tech n ology Roa dm a p for Sem icon du ctor , we a re in u rgen t n eed for a tes t in g s olu t ion for th e h igh -frequ en cy s er ia l com m u n ica t ion in ter fa ces . Ser ia lizer / des er ia lizer (SerDes ) IP cores ru n n in g a t u p to 10Gb/ s a re com m on a n d a re qu ick ly popu la ted th e SoC ASICs in grea t n u m ber . Mos t SerDes do equ ipped with bu ilt -in s elf-tes t (BIST); h owever , th es e a re for loop-ba ck fu n ct ion a l tes t on ly. Th e rea l cru cia l jit ter a n d jit ter tolera n ce for BER (b it -er ror -ra te) tes ts a re left for th e extern a l ATE. However , ATEs a re h a vin g d ifficu lt t im e to ca tch u p th e s peed of SerDes (40-56Gb/ s h a s been dem on s t ra ted); a n d th e s h eer n u m ber of SerDes in a SoC is s im ply too la rge (150 SerDes on a s in gle SoC ASIC) to be h a n d led cos t effect ively. Th erefore, we believe th e s olu t ion s h ou ld com e a s a BIST for SerDes th a t is ca pa b le of jit ter a n d jit ter tolera n ce tes t in g. Th ree m a jor res ea rch p rob lem s ca n rea d ily be iden t ified : (1 ) ca n we m ea s u re s u b-p ico-s econ d jit ter on -ch ip? (2 ) ca n th e jit ter BIST tolera te th e p roces s va r ia b ility? a n d (3 ) ca n we m in im ize th e im pa ct to th e per form a n ce of SerDes ? Es s en t ia lly, th e t ra d it ion a l m eth od of s ign a l a cqu is it ion will n ot work for th is p rob lem , a s th e requ irem en t for a n ext rem ely h igh -s peed gold referen ce s ign a l is im pos s ib le. We h a ve recen t p ropos ed a n ew m ea s u rem en t circu it des ign in wh ich p ico-s econ d ra n ge jit ter ca n be m ea s u red on -ch ip with lower frequ en cy referen ce s ign a l. We believe th is des ign h a s p rom is in g fea tu res to a n s wer th e a bove qu es t ion s a n d be a core bu ild in g b lock for th e jit ter BIST for h igh -frequ en cy SerDes in SoC. BIOGRAPHY J ien -Ch u n g Lo gra du a ted from Ta ipei In s t itu te of Tech n ology, m a jor in g in Elect ron ic En gin eer in g, in 1981 . He received h is M.S. a n d Ph .D., both in Com pu ter En gin eer in g, from th e Un ivers ity of Sou th wes tern Lou is ia n a , La fa yet te, Lou is ia n a , in 1987 a n d 1989 , res pect ively. He join ed th e Un ivers ity of Rh ode Is la n d in 1989 a n d is cu r ren t ly a Profes s or a t th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g. In 1996 , h e wa s a vis it in g res ea rch p rofes s or a t th e Tokyo In s t itu te of Tech n ology. He s erved a s th e Gen era l Ch a ir of th e IEEE 8 th Nor th At la n t ic Tes t Works h op , Wes t Green wich , RI, Ma y 1999 . He wa s th e Gen era l Co-Ch a ir of th e IEEE Sym pos iu m on Defect a n d Fa u lt Tolera n ce in VLSI Sys tem s , Ca liforn ia , October 2001 , a n d th e Progra m Ch a ir for it s 2000 m eet in g. He is cu r ren t ly s erved on th e p rogra m a n d s teer in g com m it tees of s evera l con feren ces a n d works h ops . He s erved a s gu es t ed itor for th e J ou rn a l of Sys tem Arch itectu re, E ls evier Pu b ., in 2002 . He is cu r ren t ly a n As s ocia te Ed itor of IEEE Tra n s a ct ion s on Com pu ters . His cu r ren t


128

res ea rch in teres ts in clu de: Relia b le logic circu it s yn th es is , t im in g m ea s u rem en t a n d m ixed-s ign a l m odelin g a n d tes t in g. Dr . Lo is a s en ior m em ber of IEEE Com pu ter Society.


129


Con s t ra in ed Tra n s it ion Fa u lt ATPG to Redu ce Yield Los s in SOCs

Xiao Liu and Mic hae l S . Hs iao

Bra dley Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g Virgin ia Tech , Bla cks bu rg, 24061

Tel: 540-231-8848 Fa x: 540-231-3362

Em a il: liu x@vis c.vt .edu

ABSTRACT High er clock ra tes , s h r in k in g geom etr ies , lon ger wires , a n d in crea s ed den s ity a re m a kin g m odern SOC des ign s m ore vu ln era b le to s peed-rela ted fa ilu res . At-s peed AC tes t in g (s u ch a s Broa ds ide tes t in g) h a s been widely u s ed in in du s t ry to detect s u ch dela y-in du ced defects . However , with s ca n -ba s ed tes t in g m eth ods , m a n y pa th -dela y a n d t ra n s it ion fa u lt s th a t requ ire illega l (or u n rea ch a b le) s ta tes will be ta rgeted th rou gh th e in it ia l s ca n -in s ta te. As a res u lt , u n n eces s a r ily la rge n u m ber of fu n ct ion a lly im pos s ib le dela y-rela ted fa u lt s is tes ted , a n d s u ch pra ct ices over -exercis e th e ch ip , wh ich m a y res u lt in poten t ia l yield los s a n d la rge tes t volu m e. In th is p res en ta t ion , we propos e a n ew con cep t of tes t in g on ly fu n ct ion a lly tes ta b le t ra n s it ion fa u lt s in Broa ds ide t ra n s it ion tes t in g via a n ovel con s t ra in ed ATPG. For ea ch fu n ct ion a lly u n tes ta b le t ra n s it ion fa u lt f , a s et of illega l (u n rea ch a b le) s ta tes th a t en a b le detect ion of f is fir s t com pu ted . Th is s et of u n des ira b le illega l s ta tes is efficien t ly repres en ted a s a Boolea n form u la . Ou r con s t ra in ed ATPG th en in corpora tes th is con s t ra in t form u la to gen era te Broa ds ide vectors th a t a void th os e u n des ira b le s ta tes . In doin g s o, ou r m eth od efficien t ly gen era tes a tes t s et for fu n ct ion a lly tes ta b le t ra n s it ion fa u lt s a n d m in im izes detect ion of fu n ct ion a lly u n tes ta b le t ra n s it ion fa u lt s . Beca u s e we wa n t to a void la u n ch in g a n d propa ga t in g t ra n s it ion s in th e circu it th a t a re n ot pos s ib le in th e fu n ct ion a l m ode, a d irect ben efit of ou r m eth od is th e redu ct ion of yield los s du e to over tes t in g of th es e fu n ct ion a lly u n tes ta b le t ra n s it ion s . BIOGRAPHY Xia o Liu received h is B.S. a n d M. S . in E lect r ica l En gin eer in g, both from Hu a zh on g Un ivers ity of Scien ce a n d Tech n ology, Ch in a . He h a d been s tu dyin g in th e Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g a t Ru tgers Un ivers ity, NJ from 1999 to 2001 . He t ra n s fer red to Virgin ia Tech with Dr . Mich a el S . Hs ia o on 2001 a n d cu r ren t ly is a pos t -qu a lify Ph .D ca n d ida te in Bra d ley Depa r tm en t of E lect r ica l a n d Com pu ter En gin eer in g. Now, h e is doin g co-op in th e Sys tem LSI Depa r tm en t of NEC La bora tor ies , Am er ica on dela y tes t in g. He h a s been work in g on th e ATPG, DFT a n d com pa ct ion for t ra n s it ion fa u lt tes t in g in th e la s t th ree yea rs a n d h is cu r ren t res ea rch in teres ts in clu de t ra n s it ion fa u lt tes t in g, dela y tes t in g a n d t im in g ver ifica t ion .


130


Open Arch itectu re ATE: Softwa re Con s idera t ion s

Yuhai Ma

Adva n tes t Am er ica , In c. 3201 Scot t Bou leva rd

Sa n ta Cla ra , CA 95054 Tel: 408-9697559 Fa x: 408-9870691

Em a il: y.m a @a dva n tes t .com

ABSTRACT Toda y, th e ATE (Au tom a ted Tes t Equ ipm en t) in du s t ry is fa cin g a tech n ologica l revolu t ion , in wh ich a n ew Open Arch itectu re ATE is em ergin g, wh ich is com pet in g with a n d will even tu a lly rep la ce t ra d it ion a l ATE. Th is n ew con cep t of Open Arch itectu re ATE is becom in g a very h ot top ic th a t is bein g d is cu s s ed in th e in du s t ry. In order to defin e th e n ew open a rch itectu re ATE to s olve th e ch a llen ges of cos t -effect ively tes t in g com plex s em icon du ctor devices in clu d in g Sys tem -on -Ch ips (SoCs ), Sys tem -in -Pa cka ges (SiPs ) a n d oth er com plica ted devices , th e Sem icon du ctor Tes t Con s or t iu m (STC), In c., a n in du s t ry-wide in it ia t ive, is form ed a m on g ATE u s ers , ATE ven dors , a n d m odu le ven dors . Th e STC is n ow defin in g th e s pecifica t ion of th e Open Sem icon du ctor Tes t Arch itectu re — OPENSTAR™ a n d h a s relea s ed th e fir s t d ra ft of th e s pecifica t ion . Th e OPENSTAR™ tes t p la t form provides recon figu ra b ility a n d s ca la b ility to be ca pa b le of cop in g with va r iou s tes t requ irem en ts a n d preven t in g tes ter obs oles cen ce. Th e OPENSTAR™ s ys tem a rch itectu re p rovides s u ppor t for m u lt ip le h a rdwa re im plem en ta t ion s a n d ca n be con cep tu a lly en vis ion ed a s a d is t r ibu ted s ys tem . Ea ch tes t s ite is en vis ion ed a s ded ica ted to tes t in g a s in gle device u n der tes t (DUT), a n d fu n ct ion s th rou gh a con figu ra b le collect ion of tes t m odu les . Ea ch tes t m odu le is a n en t ity th a t per form s a pa r t icu la r tes ter fu n ct ion . For exa m ple, a tes t m odu le cou ld be a device power s u pp ly, a p in ca rd , a n a n a log ca rd , etc. Th is m odu la r a pproa ch pro-vides a h igh degree of flexib ility a n d con figu ra b ility. For exa m ple, a collect ion of s ixteen 64-p in m odu les cou ld be con figu red in to eigh t tes t s ites to s erve a s s epa ra te, in depen den t u n it s to tes t eigh t s epa ra te 128 p in -cou n t DUTs , or in to two tes t s ites for two 512 p in -cou n t DUTs , or on e s ite for a 1024 p in -cou n t DUT. In ea ch con figu ra t ion , th e tes t s ite is u n der th e con t rol of a s in gle Site Con troller . Ea ch type of tes t m odu le s u ppor ts a pa r t icu la r , s ta n da rd in ter fa ce th a t en a b les th e Site Con troller to com m u n ica te with it . Th is s ta n da rd iza t ion of th e com m u n ica t ion s in ter fa ce, a s well a s in ter -m odu le com m u n ica t ion s a n d con n ect ivity to ch a s s is a llows for a h igh degree of p lu g-a n d-p la y between con form in g m odu les from d ifferen t ven dors . Ea ch Site Con troller cou ld be dep loyed on it s own ded ica ted CPU, or a s a s epa ra te p roces s s h a r in g th e s a m e CPU with th e Sys tem Con troller a n d / or oth er Site Con troller s . Th e com m u n ica t ion between a Site Con troller a n d a m odu le-s et cou ld be p rovided by a va r iety of con n ect ivity en a b lin g h a rdwa re, a s lon g a s it s erves a s a h igh -s peed bu s for fa s t da ta t ra n s fer (for loa d in g pa t tern da ta , ga th er in g res pon s e da ta , a n d p rovid in g con t rol, etc.). Th is a rch itectu re a llows for u n h in dered s ca lin g u p a s per -s ite tes t com plexity in crea s es , or th e n u m ber of in depen den t tes t s ites in crea s es . Th e cen t ra l Sys tem Con troller , with lim ited res pon s ib ilit ies for tes t s ta t ion fu n ct ion a lity, is n ot a s ta xed a s in a s ys tem wh ere th e cen t ra l Sys tem Con troller h a s res pon s ib ilit ies for m a n a gin g a ll tes t s ite fu n ct ion s . With m os t of th e tes t


131

s ta t ion fu n ct ion a lity bein g relega ted to th e Site Con troller s — th u s a llowin g in depen den t tes t s ite opera t ion — th e Sys tem Con troller s erves a s th e overa ll s ys tem m a n a ger . Th is coord in a tes th e Site Con troller a ct ivit ies , m a n a ges s ys tem -level pa ra llel tes t s t ra tegies , a n d p rovides for h a n d ler / p robe con t rols a s well a s s ys tem -level da ta loggin g a n d er ror h a n d lin g s u ppor t . Th e OPENSTAR™ Softwa re p roject is a im ed a t deliver in g a m odu la r ATE s olu t ion th a t s ca les well a n d is ext rem ely flexib le. Th e OPENSTAR™ Tes ter Opera t in g Sys tem (TOS) s oftwa re is a d is t r ibu ted s ys tem th a t h a s com pon en ts dep loyed a cros s th e Sys tem Con troller a n d th e Site Con troller s . Th e TOS h a s two pr in cipa l opera t in g m odes : on lin e a n d offlin e. Th e form er im plies a ctu a l tes ter h a rdwa re, wh ile th e la t ter p rovides s ys tem h a rdwa re em u la t ion . Th e Sys tem Con troller s oftwa re is th e p r im a ry poin t of in tera ct ion for a tes t en gin eer in ver ifica t ion a n d / or debu g en viron m en t . It p rovides th e ga tewa y to th e Site Con troller s , a n d s yn ch ron iza t ion of th e Site Con troller s in a m u lt i-s ite/ DUT en viron m en t . Us er a pp lica t ion s a n d tools — gra ph ica l u s er in ter fa ce (GUI)-ba s ed or oth erwis e — ru n on th e Sys tem Con troller . Th e Sys tem Con troller cou ld a ls o a ct a s th e repos itory for a ll tes t p la n rela ted in form a t ion , in clu d in g com piled tes t p la n s , com piled pa t tern s , tes t con d it ion s or pa ra m eters files , etc. Th e OPENSTAR™ Softwa re s u ppor ts tes ter con figu ra t ion s with Site Con troller s bein g res pon s ib le for ru n n in g on e or m ore DUTs , i.e., t es t s ites . Hen ce, in a s ys tem com pr is in g m u lt ip le Site Con troller s , ea ch Site Con troller con t rols tes t in g of on e or m ore DUTs , execu t in g th e tes t en gin eer ’s tes t p rogra m s . For ea ch s ite it con t rols , it p rovides h igh -level s yn ch ron iza t ion of th e tes t m odu les cor res pon din g to th e DUT. It is im por ta n t to n ote h ere th a t on e s h ou ld n ot equ a te a tes t s ite with a Site Con troller . A s in gle Site Con troller ca n con t rol on e or m ore tes t s ites , a n d pu rely from a s oftwa re a rch itectu re poin t of view, th ere is n o res t r ict ion on th e n u m ber of s ites con t rolled by a s in gle Site Con troller (a pa r t from u s u a l com pu ter s ys tem res ou rce con s idera t ion s ). Th e Modu les p rovide h a rdwa re com pon en ts to s u ppor t device tes t in g, s u ch a s d igita l tes ter ch a n n els , device power s u pp lies , or pa ra m etr ic m ea s u rem en t u n it s . Modu le s oftwa re con t rols a pa r t icu la r in s t ru m en t h a rdwa re m odu le. Th e OPENSTAR™ a rch itectu re a llows ATE developers a n d h a rdwa re a n d s oftwa re m odu le developers to con cen t ra te on develop in g n ew tes t s olu t ion s a n d in n ova t in g b rea k th rou gh tech n ologies for ou r in du s t ry. OPENSTAR™ p rovides a p ra ct ica l s olu t ion for th e s em icon du ctor in du s t ry to t im ely offer d ivers it ies of requ ired tes t in g fu n ct ion s , p rolon g th e life of ATE, a n d even tu a lly s olve th e ch a llen ges of cos t -effect ively tes t in g com plex s em icon du ctor devices in clu d in g SoCs , S iPs a n d oth er com plica ted devices . BIOGRAPHY Yuhai Ma r eceived h is B.S. degree in Com pu ter En gin eer in g from th e Depa r tm en t of Com pu ter En gin eer in g a t Sh a n don g Polytech n ic Un ivers ity in J in a n , Ch in a in 1987 , a n d Ph .D. degree in Com pu ter En gin eer in g from th e In s t itu te of Com pu t in g Tech n ology a t Ch in es e Aca dem y of Scien ces in Beijin g, Ch in a in 1995 . From 1987 to 1992 , h e ta u gh t in th e Depa r tm en t of Ma th em a t ics a t Qu fu Tea ch ers Un ivers ity in Sh a n don g, Ch in a . From 1995 to 1997 , h e pu rs u ed h is pos t -doctora l res ea rch p rogra m in Elect ron ics a n d Com m u n ica t ion in th e In s t itu te of Microelect ron ics a t Ts in gh u a Un ivers ity in Beijin g, Ch in a . Dr . Ma is with Adva n tes t Am er ica , In c. He s erves on th e tech n ica l p rogra m com m it tee for th e IEEE Nor th At la n t ic Tes t Works h op (NATW) from 1999 to 2003 . Dr . Ma is a m em ber of th e IEEE a n d th e IEEE Com pu ter Society, a n d h e is a ls o a m em ber of th e Sem icon du ctor Tes t Con s or t iu m (STC), In c. His res ea rch in teres ts in clu de Open Arch itectu re ATE, Softwa re En gin eer in g, ATE Softwa re, a n d VLSI Tes t in g.


132

T16 - Tech n ica l Ses s ion 16 : Bioin form a t ics (IV)

Ses s ion Ch a ir

Sim on Lin

Ma n a ger , Bioin form a t ics Core Fa cility Du ke Un ivers ity Medica l Cen ter

Tel: 919-681-9646 Fa x: 919-681-8028

Em a il: Lin 00025@m c.du ke.edu

BIOGRAPHY Dr . S im on Lin is th e tech n ica l m a n a ger of th e b ioin form a t ics core fa cility a t Du ke Un ivers ity Medica l Cen ter s in ce 1999 . He wa s a ppoin ted a s a res ea rch a s s is ta n t p rofes s or s in ce 2002 . His res ea rch in teres t in clu des m edica l gen om ics da ta m in in g a n d kn owledge d is covery. He ed ited th ree books on Microa r ra y Da ta An a lys is . Bes ides res ea rch , h e is tea ch in g Gen om e In form a t ics , a n ew cou rs e in th e Ph .D. p rogra m of Bioin form a t ics . Dr . Lin received h is M.D. degree from th e m edica l s cien t is t t r a in in g p rogra m a t Pek in g Un ivers ity Sch ool of Medicin e in 1996; a n d h is M.S. degree in m olecu la r b ioph ys ics from Un ivers ity of Nor th Ca rolin a a t Ch a pel Hill in 1999 . In th e 80s , h e wa s a lea d s oftwa re en gin eer in th e Golden Apple s oftwa re developm en t tea m . Produ cts focu s ed on icon -ba s ed m u lt ilin gu a l a n d m u lt im edia opera t in g s ys tem ru n n in g on Rockwell 6500 CPUs , in clu d in g Apple II, Com m odore 64 , a n d CEC com pu ters . In th e 90s , h e developed in teres ts in m edica l in form a t ics . His d is s er ta t ion p roject wa s a b ioin form a t ics s tu dy on m RNA s t ru ctu res . It r es u lted in a com pu ter p rogra m to op t im ize p rotein p rodu ct ion for b ioph a rm a ceu t ica l in du s t ry. Du r in g h is t ra in in g in b ioph ys ics a t th e Un ivers ity of Nor th Ca rolin a a t Ch a pel Hill, h e developed a h igh -th rou gh pu t d ru g s creen in g a s s a y a n d d is covered a n ovel a ct iva tor of a ca lciu m ch a n n el by com pu ta t ion a l ch em is t ry. He is th e fou n din g ch a ir of a n a n n u a l in tern a t ion a l con feren ce on th e Cr it ica l As s es s m en t of Microa r ra y Da ta An a lys is (CAMDA). He is on th e s cien t ific com m it tee of ACM BioKDD works h ops , a n d th e At la n t ic Sym pos iu m on Com pu ta t ion a l Biology. He is a ls o on th e boa rd of th e As s ocia t ion of Ch in es e Bioin form a t icia n s (ACBIX), a n on -profit orga n iza t ion regis tered in th e Sta te of Pen n s ylva n ia to p rom ote ca reer developm en t for Ch in es e b ioin form a t ics p rofes s ion a ls .


133

T16 - Tech n ica l Ses s ion 16 : Bin in form a t ics (IV)

An In tegra ted Bioin form a t ics Approa ch for Proteom ic Expres s ion An a lys is of Clin ica l Sa m ples a n d It s Applica t ion to Biom a rker Dis covery

Zhe n Zhang, Ph .D.

As s ocia te Profes s or a n d As s ocia te Director

Biom a rker Dis covery Cen ter Depa r tm en t of Pa th ology

J oh n s Hopkin s Un ivers ity Sch ool of Medicin e 419 Nor th Ca rolin e St reet , Rm 200

Ba lt im ore, MD 21231 Tel: 410 .502 .7871 (office) 7870 (la b) 7882 (fa x) eFa x: 413 .208 .9217

Em a il: zzh a n g7@jh m i.edu

ABSTRACT Adva n ces in h igh -th rou gh pu t expres s ion a n a lys is tech n ologies h a ve m a de it pos s ib le to s im u lta n eou s ly m ea s u re a n d crea te a p rofile of th e expres s ion levels of a la rge n u m ber of gen es or p rotein s from a s in gle b iologica l s a m ple. Wh en a pp lied to clin ica l s pecim en s , s u ch expres s ion p rofilin g tech n ologies offer p rom is in g oppor tu n it ies for th e d is covery of n ew d ia gn os t ic m a rkers a n d th era peu t ics ta rgets . However , th e p roces s in g a n d a n a lys is of h igh -d im en s ion a l expres s ion p rofilin g da ta from clin ica l s a m ples a re very d ifferen t from th os e on da ta from b iologica l s a m ples ob ta in ed u n der con t rolled exper im en ta l con d it ion s . An a ppropr ia te b ioin form a t ics a pproa ch requ ires th e in tegra t ion of (1 ) s ta t is t ica lly s ou n d s tu dy des ign s , (2 ) com pu ta t ion a l m eth ods th a t m a xim ize th e u s e of in form a t ion from lim ited s a m ples wh ile a llevia t in g th e im pa ct of n on -d is ea s e rela ted va r ia b ility a n d b ia s es , a n d m os t im por ta n t ly, (3 ) clin ica l a n d b iologica l kn owledge a bou t th e d is ea s e p roces s es . Th e m a in goa l of res ea rch a t th e Biom a rker Dis covery Cen ter is to d is cover a n d va lida te tu m or m a rkers for th e ea r ly detect ion of a n u m ber of m a jor ca n cers u s in g p rotein expres s ion p rofilin g of clin ica l s a m ples . Cu r ren t ly m os t of ou r p rofilin g da ta h a ve been ob ta in ed u s in g Su r fa ce-En h a n ced La s er Des orp t ion a n d Ion iza t ion (SELDI) Tim e-of-fligh t Ma s s Spect rom eters (TOF-MS). Th e ta lk will be d ivided in to th ree pa r ts . Th e fir s t pa r t des cr ibes th e gen era l p roces s of b iom a rker d is covery a n d va lida t ion for clin ica l a pp lica t ion s a n d h ow it im pos es a n u m ber of s pecia l requ irem en ts on b ioin form a t ics a pproa ch es . Th e s econ d pa r t in t rodu ces th e ba s ic con cep t of a s u pervis ed lea rn in g a lgor ith m ca lled Un ified Ma xim u m Sepa ra b ility An a lys is (UMSA) th a t we developed for th e a n a lys is of h igh -d im en s ion a l da ta . By com bin in g th e t ra d it ion a l d is t r ibu t ion -ba s ed s ta t is t ica l cla s s ifica t ion m eth ods with th e em pir ica l r is k m in im iza t ion m eth od of Su ppor t Vector Ma ch in e (SVM), UMSA is pa r t icu la r ly s u ita b le for th e a n a lys is of h igh -d im en s ion a l expres s ion p rofilin g da ta from a rela t ively s m a ll n u m ber of clin ica l s a m ples . Fin a lly, th e th ird pa r t p res en ts a la rge-s ca le m u lt i-cen ter s tu dy recen t ly com pleted a t th e Biom a rker Dis covery Cen ter for th e ea r ly detect ion of ova r ia n ca n cer . Th e p roces s es in volved in s tu dy des ign a n d da ta a n a lys is exem plify th e is s u es a n d propos ed a pproa ch es d is cu s s ed in th e fir s t two pa r ts . BIOGRAPHY Zh en Zh a n g is cu r ren t ly a n a s s ocia te p rofes s or in th e Depa r tm en t of Pa th ology a t J oh n s Hopkin s Un ivers ity Sch ool of Medicin e a n d a s s ocia te d irector of th e Biom a rker Dis covery Cen ter . Pr ior to join in g J oh n s Hopkin s , h e h a d been a fa cu lty m em ber a t th e Medica l Un ivers ity of Sou th Ca rolin a in Ch a r les ton , SC for fou r teen yea rs . Du r in g 1994 - 2002 , h e wa s a ls o th e s en ior vice p res iden t of Horu s Th era peu t ics , In c., a b iotech com pa n y s pecia lized in com pu ter -


134

a s s is ted m edicin e th a t h a s s in ce s old it s a s s ets , in clu d in g a n u m ber of pa ten ts of wh ich Zh en Zh a n g is a n in ven tor or co-in ven tor to J oh n s on a n d J oh n s on . Wh ile with Horu s , h e developed Pros tAs u re, a n eu ra l n etwork ba s ed p red ict ive m odel for a s s es s in g r is k of p ros ta te ca n cer , wh ich wa s on e of th e fir s t s u ch p rodu cts th a t h a d a ctu a lly been com m ercia lized a n d offered by a la rge n u m ber of referen ce la bora tor ies . He is a ls o cu r ren t ly th e p res iden t of 3Z In form a t ics , LLC, a s m a ll com pa n y h e fou n ded to develop s pecia lized b ioin form a t ics s oftwa re tools . Zh en Zh a n g received h is Ph .D. in Elect r ica l En gin eer in g from Un ivers ity of Pit t s bu rgh in 1987 . Over th e yea rs , h e worked in a n u m ber of d ivers e a rea s in clu d in g s eis m ic da ta a n a lys is for n a tu ra l res ou rces exp lora t ion , con foca l im a ge a n a lys is of develop in g em bryon ic h ea r t , pep t ide s equ en cin g from CID m a s s s pect ra , b iologica l s equ en ce a n a lys is , a n d m os t recen t ly, b iologica l expres s ion da ta a n a lys is for clin ica l p roteom ics . His in teres t in b ioin form a t ics h a s a lwa ys been in tool-m a kin g. However , to h a ve s om eon e pa y for s u ch a ct ivit ies , h e h a s a ls o h a d to do s om e a ctu a l da ta a n a lys is u s in g h is a n d oth er peop le’s tools .


135


Un iMa rker a s a Fa s t Sequ en ce Ma ppin g a n d Gen om e Com pa r is on Meth od

Ming-Jing Hwang

Associate Research fellow Institute of Biomedical Sciences

Academia Sinica Tel: 886-2-2789-9033 Fax: 886-2-2788-7641

Email: [email protected]

ABSTRACT Th e tor ren t of gen om ic s equ en ce da ta a n d th e ra p id ly in crea s in g n u m ber of com pletely s equ en ced gen om es h a ve in crea s ed th e n eed for a m ore efficien t a n d a ccu ra te b ioin form a t ics tool for com pa r in g DNA s equ en ces . Tra d it ion a lly, BLAST (Ba s ic Loca l Align m en t Sea rch Tool) or BLAST-ba s ed s equ en ce a lign m en t h a s been th e m eth od of ch oice for DNA s equ en ce com pa r is on , des p ite th e com pu ta t ion a l cos t , wh ich es ca la tes with in crea s ed len gth of th e s equ en ce, s u ch a s th e h u m a n gen om e. We h a ve recen t ly developed a s equ en ce a lign m en t-free m eth od th a t is s evera l h u n dred t im es fa s ter th a n s equ en ce a lign m en t m eth ods for gen om e-ba s ed s equ en ce m a ppin g a n d com pa r is on . By m a tch in g gen om e-wide u n iqu e 16-m er DNA s equ en ce words (th os e th a t a ppea r exa ct ly on ce in th e gen om e a n d a re th erefore ca lled Un iMa rkers or UMs ), we h a ve been a b le to d is pen s e with th e u s u a l requ irem en t for s equ en ce a lign m en t a n d to gen om ica lly pos it ion th e en t ire da ta ba s e of h u m a n s in gle n u cleot ide polym orph is m (SNP) s equ en ces in a few h ou rs u s in g a s in gle des k top com pu ter . By a n a lyzin g a gen om e-wide occu r ren ce s pect ru m of th e s a m e UMs pres en t in both th e h u m a n a n d m ou s e gen om es , we h a ve a ls o been a b le to com pa re th e two m a m m a lia n gen om es with th e s a m e com pu ta t ion a l efficien cy, wh ile p rodu cin g a h u m a n -m ou s e s yn ten y m a p th a t is in excellen t a greem en t with th a t repor ted by th e Mou s e Gen om e Sequ en cin g Con s or t iu m . In th is ta lk , th e Un iMa rker (UM) m eth od a n d it s a pp lica t ion for detect in g or th ologou s region s between la rge gen om es (i.e. s yn ten y m a ppin g) will be p res en ted . BIOGRAPHY Dr . Min g-J in g Hwa n g h a s been a Pr in cipa l In ves t iga tor for th e La bora tory for Bioin form a t ics a n d Biom olecu le Modelin g a t th e In s t itu te of Biom edica l Scien ces a t th e Aca dem ia Sin ica s in ce 1994 . Cu r ren t ly, h e is a ls o a n a d ju n ct As s ocia te Profes s or a t th e In s t itu te of Bioch em is t ry a n d th e In s t itu te of Bioin form a t ics , Na t ion a l Ya n g Min g Un ivers ity, a n d a t th e Gra du a te In s t itu te of Life Scien ces of th e Na t ion a l Defen s e Medica l Cen ter . His recen t res ea rch h a s focu s ed on develop in g fa s t DNA s equ en ce a n d protein th ree-d im en s ion a l s t ru ctu re com pa r is on a lgor ith m s , a n d u s in g th em to s tu dy th e orga n iza t ion a n d evolu t ion of gen om e a n d protein s t ru ctu res . His la bora tory h a s p rodu ced a n u m ber of b ioin form a t ics s oftwa re tools , m os t of wh ich a re freely a cces s ib le from th e la bora tory webs ite, a t h t tp :/ / gln .ibm s .s in ica .edu .tw/ s oftwa re.ph p . Between 1989 a n d 1994 , Dr . Hwa n g worked for Bios ym Tech n ologies In c. (Sa n Diego, CA), fir s t a s a pos tdoctora l res ea rch a s s ocia te, th en a s a s cien t is t a n d p roject lea der . He h elped lea d a tea m fu n ded by a con s or t iu m of ph a rm a ceu t ica l a n d ch em ica l com pa n ies to develop a s u ite of n ew-gen era t ion m olecu la r en ergy fu n ct ion s for th e s im u la t ion a n d m odelin g of b iologica l a n d ch em ica l m olecu les .


136

Dr . Hwa n g received a B.Sc. from th e Na t ion a l Ta iwa n Un ivers ity, a n M.Sc. from Wes t Virgin ia Un ivers ity (Morga n town , WVa ), a n d a Ph .D. from th e Un ivers ity of Pit t s bu rgh (Pit t s bu rgh , PA), a ll in th e field of ch em ica l en gin eer in g. He wa s born a n d grew u p in a s m a ll town in Ta in a n Cou n ty, Ta iwa n .


137


SNPs – from Tech n ology to Applica t ion

Clive Bowm an

Director Popu la t ion Gen et ics , Gen et ics Res ea rch , Gen et ics Res ea rch , UK Tel: +44-1438-768095 Fa x: +44-1438-764231

Em a il: clive.e.bowm a n @gs k .com

ABSTRACT A Sin gle Nu cleot ide Polym orph is m (SNP) is on e of th e m os t com m on types of gen et ic d ivers ity fou n d in m a n . Recen t es t im a tes , ba s ed on a n a lys is of m a n y ch rom os om a l region s a n d a d ivers e pa n el of s u b jects , s u gges t a frequ en cy of 1 SNP per 500 – 1 ,000 ba s e pa ir s . Beca u s e of th is h igh in ciden ce of d ivers ity in th e h u m a n popu la t ion , SNPs h a ve been p ropos ed to be th e m eth od of ch oice for th e iden t ifica t ion of loci a s s ocia ted with com plex d is ea s es a n d va r iou s Ph a rm a cogen et ics s tu d ies . Th e t rem en dou s s u cces s of Th e SNP Con s or t iu m to p rovide pu b licly a va ila b le SNPs h a s m a de wh ole gen om e a s s ocia t ion s tu d ies u s in g SNPs a rea lis t ic a pproa ch . In a dd it ion , th e In tern a t ion a l Ha pMa p Project h a s p rom is ed to p rovide th e m os t in form a t ive SNPs a n d va lida ted gen otyp in g a s s a ys for wh ole gen om e a s s ocia t ion s tu d ies . Th is p res en ta t ion will r eview th e la tes t in form a t ion on th e p roper t ies of SNP m a rkers , gen otyp in g tech n ologies a n d m eth ods a va ila b le for gen et ic a n a lys is . In a dd it ion , I will s u m m a r ize oth er im por ta n t pa ra m eters to be con s idered wh en a pp lyin g SNP tech n ologies in Gen et ic Res ea rch a n d in Hea lth ca re. BIOGRAPHY Clive Bowm a n C.Sta t FLS is Director Popu la t ion Gen et ics , Dis covery Gen et ics , Gen et ics Res ea rch a t Gla xoSm ith Klin e. For th e deca de p r ior to join in g Gla xoWellcom e in 1998 , Clive own ed a n d ra n s pecia lis t Clin ica l Res ea rch Orga n iza t ion s . Clive received h is MSc., in Biom etr ics from Rea d in g Un ivers ity, UK in 1985 u n der th e gu ida n ce of Prof. Roger Mea d s pecia lizin g in des ign . In 1993 h e beca m e a Fellow of Roya l Sta t is t ica l Society. He h a s led a va r iety of roles in da ta exp lora t ion , s ta t is t ics , QA, IT, ph a rm a cokin et ics a n d pu b lis h in g . For th e pa s t five yea rs , Clive a n d oth er GSK s cien t is t s h a ve been lea d in g th e wa y in th e u s e of h igh den s ity wh ole gen om e SNP m a ps in th e s ea rch for s u s cep t ib ility gen es a n d in ph a rm a cogen et ics .


138

T17 - Tech n ica l Ses s ion 17 : C4I (V): Ubiqu itou s Com m u n ica t ion s a n d Com pu t in g

Ses s ion Ch a ir

Sing Lin

Pres iden t , CSC Res ea rch LLC Tel: 732-946-4176 Fa x: 732-946-7148

Em a il: s in g-lin @m on m ou th .com BIOGRAPHY Dr . S in g Lin h a s been a m em ber of th e US Delega t ion to ITU (h t tp :/ / www.itu .in t / h om e/ ) for m ore th a n 20 yea rs develop in g globa l s ta n da rds for va r iou s wireles s com m u n ica t ion s s ys tem s in clu d in g th e Th ird Gen era t ion (3G) IMT-2000 wireles s s ys tem s a n d beyon d . He is cu r ren t ly th e Pres iden t of CSC Res ea rch , LLC. He wa s th e Sen ior Vice Pres iden t of Lin k Com m u n ica t ion s In c. from 2000 to 2001 . In th e 1998-1999 t im efra m e, Dr . Lin wa s a Dis t r ict Ma n a ger for Wireles s Sta n da rds Ma n a gem en t in AT&T La bora tor ies . From 1984 to 1998 , h e wa s th e Director for Wireles s Tech n ologies in Telcord ia (form er ly Bellcore). He wa s a tech n ica l s u pervis or from 1979 to 1984 on m icrowa ve ra d io s ys tem s tech n ologies in Bell La bora tor ies . He received th e Ph .D. degree in Elect r ica l En gin eer in g from th e Un ivers ity of Ca liforn ia a t Berkeley in 1969 a n d th e B.S.E .E . degree from th e Na t ion a l Ta iwa n Un ivers ity in Ta ipei, Ta iwa n in 1963 . Dr . Lin is th e recip ien t of Bellcore Awa rd of Excellen ce, IBM Fellows h ip a t th e Un ivers ity of Ca liforn ia a n d In s t itu t ion Service Awa rd of th e Ch in es e In s t itu te of En gin eers – USA (CIE-USA h t tp :/ / www.cie-u s a .org/ h ea d lin es .ph p ). Dr . Lin wa s a m em ber of th e Na t ion a l Cou n cil of CIE-USA a n d wa s th e Pres iden t of th e Grea ter New York Ch a pter of CIE-USA (h t tp :/ / 207 .218 .99 .194 / ) in 1998 a n d 1999 . He h a s been a m em ber of th e Telecom Advis ory Boa rd of th e Min is t ry of Tra n s por ta t ion a n d Com m u n ica t ion s in Ta iwa n for m ore th a n 10 yea rs . He h a s a ls o been a m em ber of th e Pla n n in g Com m it tee of th e a n n u a l Wireles s a n d Opt ica l Com m u n ica t ion s Con feren ce (WOCC h t tp :/ / www.wocc.org/ ).


139


Ses s ion Ch a ir

J ung-Tao Liu

Mem ber of Tech n ica l S ta ff Lu cen t Tech n ologies Tel: 973-386-3535 Fa x: 973-386-3409

Em a il: jt liu @lu cen t .com BIOGRAPHY J u n g-Ta o Liu received th e B.S. degree in elect r ica l en gin eer in g from Na t ion a l Ta iwa n Un ivers ity, Ta ipei, Ta iwa n , in 1992 a n d th e M.S. a n d Ph .D. degree from th e Sch ool of E lect r ica l a n d Com pu ter En gin eer in g a t Pu rdu e Un ivers ity in 1997 a n d 1999 , res pect ively. S in ce th en , h e h a s been a t Lu cen t Tech n ologies , Wh ippa n y, NJ , USA wh ere h e in it ia lly worked on th e a lgor ith m des ign for GPRS/ EDGE receiver . Recen t ly, h e h a s been work in g on th e h igh s peed pa cket da ta for WCDMA, MIMO tech n ologies for HSDPA in UMTS. Cu r ren t ly, He is a Mem ber of Tech n ica l S ta ff in CDMA Sys tem s Tech n ology Grou p , work in g on m u lt im edia b roa dca s t a n d m u lt ica s t in g, h igh s peed u p lin k da ta a cces s in UMTS a n d h igh s peed da ta u s in g OFDM. In gen era l, h e is in teres ted in th e res ea rch of wireles s com m u n ica t ion th eor ies ; m ore s pecifica lly, His cu r ren t in teres ts in clu de cod in g th eory, equ a liza t ion , m u lt ip le a n ten n a tech n ologies , a da p t ive m odu la t ion , lin k a da p ta t ion , fa s t s ch edu lin g, m u lt i-ton e/ m u lt i-ca r r ier wireles s com m u n ica t ion s . He received th e Recogn it ion of Excellen ce Awa rd from Lu cen t Tech n ologies in J u n e 2000 for h is con t r ibu t ion on EDGE, a n d th e Bell La bs Pres iden t ’s Gold Awa rd in 2002 for h is work on th e MIMO BLAST project . He h a s 27 pa ten ts pen d in g a n d h a s a u th ored / co-a u th ored va r iou s n u m ber of con feren ce, jou rn a l a n d tech n ica l pa pers . He is cu r ren t ly s ervin g in th e tech n ica l p rogra m com m it tee for CCNC’04 .


140


Con vergen ce of “Com m u n ica t ion s ”

Anwar Siddiqui

Tech n ica l Ma n a ger Ava ya Ch ief Tech n ology Office

Ava ya In c. Tel: 732-852-3200

Em a il: a n wa rs @a va ya .com

ABSTRACT Rea l-t im e in tern et com m u n ica t ion is d r ivin g th e con vergen ce of com m u n ica t ion . Th e a lwa ys con n ected ch a ra cter is t ics of n etworks , in crea s ed a cces s s peed , a n d th e a dva n cem en t of d is t r ibu ted com m u n ica t ion p roces s in g a rch itectu re a re p rovid in g a n ew gen era t ion of a pp lica t ion s a n d s ervices th a t were n ot p la u s ib le ju s t a few yea rs a go. Th is ta lk p rovides a n overview of th e in du s t ry d irect ion a lon g with exa m ples of a s u ite of u b iqu itou s com m u n ica t ion a pp lica t ion s developed for en terpr is e u s ers . Adva n cem en t of d is t r ibu ted com m u n ica t ion p rotocols like SIP, SIMPLE, 3GPP2, a n d Wi-Fi (IEEE 802 .11g) a re a dd in g n ew com plim en ta ry ca pa b ilit ies s u ch a s th e a b ility to determ in e th e p res en ce of u s ers in a d is t r ibu ted n etwork to p rovide en h a n ced com m u n ica t ion exper ien ce. Th is p res en ta t ion a ls o ta kes a clos er look a t va r iou s s ervice poin ts in n etwork a rch itectu re wh ere th es e a pp lica t ion s were in t rodu ced . A few exa m ples a re SIP UA in IP Ph on e, Network a pp lica t ion s rea lized by th e SIP Servers like th e Proxy, Pres en ce Servers , IM Servers , Network a pp lica t ion s rea lized in th e Fea tu re Servers , a n d Web-ba s ed Applica t ion Servers . Followin g a web pa ra d igm , th es e n ew ca pa b ilit ies , like In s ta n t Mes s a gin g, Bu ddy Lis ts , in tegra t ion of 3G/ Wi-Fi n etworks , Pres en ce, a n d Pres en ce-en a b led voice m a ils in con ju n ct ion with exis t in g ca pa b ilit ies , en a b le th e crea t ion of m obile pers on a l works pa ces wh ere th e en d u s ers con s t itu te free a gen cies . BIOGRAPHY An wa r Sidd iqu i is cu r ren t ly a Tech n ica l Ma n a ger of th e Ava ya Ch ief Tech n ology Office (CTO) in Lin croft , New J ers ey. He is res pon s ib le for iden t ifyin g em ergin g tech n ologies th a t a re s t ra tegic to th e im plem en ta t ion of Ava ya ’s con verged com m u n ica t ion vis ion . His a rea s of in teres t in clu de ca ll p roces s in g in IP n etworks , com m u n ica t ion s u ppor t for d is t r ibu ted s ys tem s , a n d com m u n ica t ion p rotocols for th e In tern et , s u ch a s SIP/ H.323 , En terpr is e Applica t ion s in Wi-Fi Networks , IP/ IEEE/ 3G n etwork a gn os t ic a pp lica t ion s , Pres en ce Awa re n etworks , Network Mon itor in g & Fa u lt Tolera n ce, QOS, Network Secu r ity a n d Pr iva cy, a n d OA&M. An wa r join ed Lu cen t Tech n ologies - Bell La bora tor ies in 1998 a n d con du cted res ea rch on th e fir s t gen era t ion of Voice over IP ca ll p roces s in g s ys tem s . In 2000 , h e join ed Ava ya La bs Con verged Sys tem s Divis ion wh ere h e wa s a wa rded Dis t in gu is h ed Mem ber of th e Tech n ica l S ta ff for h is con t r ibu t ion in developm en t of Ava ya ’s En terpr is e Cla s s VoIP Sys tem s a n d va r iou s oth er Rea l-Tim e Com m u n ica t ion Sys tem s widely u s ed by For tu n e 500 com pa n ies wor ldwide. An wa r Sidd iqu i h olds a Ma s ters degree from Colu m bia Un ivers ity in th e City of New York in Elect r ica l En gin eer in g a n d a Ba ch elor degree from In d ia n In s t itu te of Tech n ology (IIT) – Bom ba y. He h olds n u m erou s pa ten ts in th e field of com pu ter com m u n ica t ion , n etwork s ecu r ity a n d pr iva cy, QoS etc. He is a n a ct ive con t r ibu tor to In tern et En gin eer in g Ta s k Force (IETF) a n d a u th or of va r iou s IETF s ta n da rd s pecifica t ion s . He is a ls o a frequ en t ly in vited s pea ker in a


141

va r iety of ven u es a cros s Nor th Am er ica , Eu rope a n d As ia Pa cific, in clu d in g p rom in en t tech n ology even ts a n d con feren ces .


142


Perva s ive Com pu t in g Solu t ion s

Paul B. Chou

Ma n a ger , Em ergin g In tera ct ive Spa ces IBM Th om a s J . Wa ts on Res ea rch Cen ter

Em a il: pch ou @u s .ibm .com

ABSTRACT Perva s ive Com pu t in g p rom is es to ch a n ge every a s pect of ou r da ily lives th rou gh th e in tegra t ion of com pu t in g n etwork with em bedded a n d wireles s m obile devices . Th e a b ility to a cces s com pu t in g on a n y device, a n y t im e a n d a n y p la ce, a ls o p ropels bu s in es s es to rea s s es s a n d t ra n s form th eir p roces s es with in n ova t ive s olu t ion s . Th is ta lk will exa m in e two s olu t ion a rea s th a t a ddres s kn owledge worker p rodu ct ivity a n d s u pp ly ch a in efficien cy, res pect ively. I will overview releva n t tech n ologies , review bu s in es s p ropos it ion s , a n d in t rodu ce ou r work in th es e a rea s . BIOGRAPHY Dr . Pa u l Ch ou is a m a n a ger a n d a Res ea rch Sta ff Mem ber in th e Perva s ive Com pu t in g Solu t ion s grou p a t th e IBM Th om a s J . Wa ts on Res ea rch Cen ter . His res ea rch focu s is on develop in g n ext gen era t ion s olu t ion s to a ddres s em ergin g bu s in es s oppor tu n it ies b rou gh t by tech n ology a dva n cem en ts in s en s ors a n d perva s ive devices . He cu r ren t ly lea ds a res ea rch tea m , ta ck lin g s oftwa re in fra s t ru ctu re a n d s olu t ion ch a llen ges a s s ocia ted with RFID. In h is p reviou s a s s ign m en ts , Pa u l led s olu t ion res ea rch p rojects in clu d in g Blu eSpa ce – Office of th e Fu tu re (www.res ea rch .ibm .com / b lu es pa ce), Au tom ot ive Telem a t ics , Cu s tom er Pros pect Opt im iza t ion , Ma n u fa ctu r in g Qu a lity Ma n a gem en t , a n d Au tom a ted Opt ica l Defect Cla s s ifica t ion . He h a s exten s ive exper ien ce a n d pu b lica t ion s in th e a rea s of perva s ive com pu t in g, da ta m in in g, a n d com pu ter vis ion s ys tem s . Pa u l received h is Ph .D. in Com pu ter Scien ce in 1988 from th e Un ivers ity of Roch es ter .


143


Mart in C. Eis e ns c hm ie d

AT&T La bs aTel: 732 420 2479 Fa x: 732 368 1768

Em a il: m ce@a t t .com

ABSTRACT Th ere a re a n u m ber of dyn a m ics d r ivin g th e n eed for wireles s (Wi-Fi) s ervices . Bu s in es s en terpr is es a re bu ild in g/ in ten d to bu ild p rem is es ba s ed Wi-Fi n etworks a n d will be in teres ted in exten d in g covera ge th rou gh pu b lic a cces s n etworks . Th ere is a s ign ifica n t n u m ber of Wi-Fi devices in p la ce toda y, wh ich is crea t in g a cr it ica l m a s s of u s ers for 802 .11 ba s ed s ervices . Ch ip ven dors a re com m it ted to in tegra t in g Wi-Fi ca pa b ilit ies for m obile-ba s ed p rodu cts (i.e. la p tops , PDAs , Cellu la r ph on es ). AT&T La bs h a s been co-develop in g a n d tes t in g n ew ca r r ier gra de s ervice offer in gs in wireles s 802 .11b tech n ology. Th e fir s t , kn own a s Pu blic Wireles s LAN or PWLAN, wa s co-developed in 2003 with IBM, In tel, a n d oth ers a s pa r t of a join t ven tu re ca lled Com eta Networks . Th e PWLAN WiFi s ervice a im s to ca p tu re a s h a re in th e growin g m a rket for wireles s a cces s s ervice for bu s in es s en d-u s ers a t a ffilia te loca t ion s like a irpor ts , r es ta u ra n ts , coffee s h ops , etc. AT&T views wireles s a s a n en a b lem en t tech n ology th a t will p rovide grea ter a cces s to en d u s ers in bu s in es s m a rkets . A m a jor pa r t of th e con cep t is to levera ge exis t in g d ia l u p a cces s s ervices like Wor ldNet Bu s in es s Dia l a n d to over la y wireles s tech n ology to u s e th e exis t in g d ia l u p a u th en t ica t ion a n d b illin g s ys tem s . BIOGRAPHY Ma r t in C. E is en s ch m ied is a Dis t r ict Ma n a ger with AT&T La bs lea d in g a res ea rch a n d tech n ica l developm en t tea m exp lor in g IP n etwork a cces s tech n ologies in th e a rea of ca b le h igh -s peed da ta , voice over IP on ca b le (Ca ble VoIP), d igita l s u bs cr iber lin e, a n d wireles s LAN (802 .11b). He ea rn ed a MA degree in com m u n ica t ion with d is t in ct ion from New York In s t itu te of Tech n ology in 1985 . He ea rn ed a BA degree in com m u n ica t ion s from Os wego Sta te Un ivers ity (SUNY) in 1978 . Mr . E is en s ch m ied h a s been work in g in th e TCP/ IP s pa ce s in ce 1983 wh en h e beca m e th e n etwork m a n a ger for th e Mou n t Sin a i Sch ool of Medicin e in New York , s u bs equ en t ly join in g AT&T Bell La bs in 1995 . Mr . E is en s ch m ied ’s ten u re a t AT&T h a s cen tered la rgely a rou n d th e tes t in g a n d developm en t of a cces s n etwork s ervice tech n ologies . Mos t recen t ly Mr . E is en s ch m ied ’s work h a s been develop in g a n d tes t in g AT&T’s fir s t s ervice offer in g in to 802 .11b tech n ology. Kn own a s Pu blic Wireles s LAN or PWLAN, th is WiFi s ervice levera ges exis t in g AT&T s ervice offer in gs in DSL, ATM, a n d pr iva te lin e.


144


Mobile Media a n d Hom e Network in g - Dr ivin g th e Con vergen ce of Com pu t in g a n d Com m u n ica t ion s

Dr. He athe r Yu

Sen ior Scien t is t

Pa n a s on ic Tel: 609-734-7325 Fa x: 609-987-8827

Em a il: h ea th ery@res ea rch .pa n a s on ic.com

ABSTRACT Con s u m ers h a ve witn es s ed a pa ra d igm s h ift in th e wa y m u lt im edia in form a t ion is received a n d d is t r ibu ted . Adva n ces in wireles s com m u n ica t ion , m obile com pu t in g a n d h om e n etwork in g a re p rovid in g u s with growin g bu s in es s oppor tu n it ies a n d dem a n ds for s ea m les s m u lt im edia s ervices to en a b le r ich , con n ected , a n d h eterogen eou s a pp lica t ion s . Th e con vergen ce of tech n ology t ren d is lea d in g towa rd offer in g con s u m ers excit in g a n d en d-to-en d exper ien ces in com m u n ica t ion s , pers on a l p rodu ct ivity a n d en ter ta in m en t a cros s a b roa d ra n ge of devices a n d n etworks . We d is cu s s th e con vergen ce t ren d a n d in ves t iga te th e a pp lica t ion of m obile m u lt im edia over h eterogen eou s n etworks in th e fir s t pa r t of th e ta lk . Sa m ple tech n ologies , s ca la b le m edia a cces s tech n ologies for s u ch a pp lica t ion s , s h a ll be a ddres s ed in th e s econ d pa r t . BIOGRAPHY Dr . Hea th er Yu is a Sen ior Scien t is t a t Pa n a s on ic In form a t ion a n d Network in g Tech n ologies La bora tory. Sh e received h er B.S. degree from Pek in g Un ivers ity, h er M.A. a n d Ph .D. degrees from Pr in ceton Un ivers ity a ll in E lect r ica l En gin eer in g. In 1998 , s h e join ed Pa n a s on ic wh ere h er m a jor focu s h a s been m u lt im edia com m u n ica t ion a n d m u lt im edia in form a t ion a cces s R&D. Righ t n ow, s h e is work in g on m obile h om e n etwork p roject wh ere h er p r im a ry in teres ts a re m u lt im edia a cces s over h eterogen eou s n etworks , wireles s / m obile m u lt im edia com m u n ica t ion s , a n d d igita l r igh ts m a n a gem en t . Cu r ren t ly, Dr . Yu s erves a s Vice Ch a ir of IEEE COMSOC Mu lt im edia Com m u n ica t ion s Tech n ica l Com m it tee, As s ocia te Ed itor for IEEE Tra n s . on Mu lt im edia , Ed itor for ACM Com pu ters in En ter ta in m en t a n d IEEE Mu lt im edia Ma ga zin e, Ed itor for J ou rn a l of In form in g Scien ce, Gu es t Ed itor of J SAC, s pecia l is s u e on Recen t Adva n ces in Wireles s Mu lt im edia , Gu es t Ed itor of Proceed in gs of IEEE, s pecia l is s u e on Mu lt im edia Secu r ity for Digita l Righ ts Ma n a gem en t , Con feren ce Steer in g Com m it tee Mem ber of IEEE ICME a n d IEEE CCNC, Tech n ica l Progra m Co-ch a ir of IEEE ICC2004 (In tern a t ion a l Con feren ce on Com m u n ica t ion s ) Mu lt im edia Tech n ologies a n d Services Sym pos iu m , Con feren ce Tech n ica l Progra m Co-Ch a ir of IEEE ITRE2003 (In t . Con f. on In fo. Tech . Res ea rch a n d Edu ca t ion 2003), Con feren ce Tech n ica l Progra m Vice co-Ch a ir of IEEE ICME2004 (In t . Con f. on Mu lt im edia a n d Expo 2004). Sh e s erved a s reviewer for m a n y ren own ed in tern a t ion a l jou rn a ls in th e a rea of m u lt im edia com m u n ica t ion a n d proces s in g. Sh e p res en ts th e tu tor ia l on Mu lt im edia s ecu r ity tech n ologies for d igita l r igh t m a n a gem en t a t ICME2003 a n d Globecom 2003 , pu b lis h ed n ea r ly 50 tech n ica l pa pers , h olds th ree US pa ten ts , a n d h a s m ore th en 20 pa ten ts pen d in g in th e m u lt im edia com m u n ica t ion , m u lt im edia in form a t ion a cces s , a n d con s u m er n etwork in g a n d com m u n ica t ion s a rea s .


145


Va r ia b le-Ph a s e-Sh ift -Ba s ed RF-Ba s eba n d Codes ign for MIMO An ten n a Select ion

Xinying Zhang

Pr in ceton Un ivers ity Tel: 609-2582081

Em a il: xin yin [email protected] in ceton .edu

ABSTRACT Th is ta lk a ddres s es th e a n ten n a s u bs et s elect ion tech n iqu e in m u lt ip le a n ten n a s ys tem s th rou gh a join t des ign of both RF ch a in s a n d ba s eba n d s ign a l p roces s in g. Wh en on ly a lim ited n u m ber of frequ en cy con ver ter s a re a va ila b le, con ven t ion a l a n ten n a s elect ion s ch em es s h ow s evere per form a n ce degra da t ion in m os t fa d in g ch a n n els . To a llevia te th os e degra da t ion s , we propos e to em bed s im ple, va r ia b le ph a s e s h ifter s in th e RF ch a in s before s elect ion . Th e con s t ra in ed op t im u m des ign of th es e s h ifter s , a da p t in g to th e ch a n n el s ta te, is given in a n a lyt ica l form th a t requ ires n o s ea rch or itera t ion s . Th e res u lt in g s ys tem s h ows a s ign ifica n t a dva n ta ge in term s of th e h a rdwa re com plexity a s well a s s ys tem per form a n ce for both cor rela ted a n d u n cor rela ted ch a n n els . Th e tech n iqu e works for both t ra n s m it ter a n d receiver des ign , wh ich in s p ires th e join t t ra n s ceiver a n ten n a s elect ion . We will cover th e ba ckgrou n d , tech n ica l deta il, a pp lica t ion a n d per form a n ce of th e h ybr id a n ten n a s elect ion s ch em e. BIOGRAPHY Ms. Xinying Zhang received the B.S. degree from Electronics Engineering Department, Tsinghua University, China in 1998. Since then she has been a Ph.D. candidate in the Department of Electrical Engineering at the Princeton University. Her research lies in the field of communications and signal processing in multiple antenna fading channels, including communication theory, channel equalization, space-time coded system, space-time diversity and multicarrier communication systems.


146

T18 - Tech n ica l Ses s ion 18 : C4I(VI): Hu m a n -Com pu ter In tegra t ion

Ses s ion Ch a ir

Dr. Mic he lle Yan

Mem ber of Tech n ica l S ta ff S iem en s Corpora te Res ea rch , In c.

Tel: 609-734-3624 Fa x: 609-734-6565

Em a il: m ich elle.ya n @s cr .s iem en s .com

BIOGRAPHY Dr . Mich elle Ya n received h er B.S from Un ivers ity of Scien ce a n d Tech n ology of Ch in a (USTC) in 1985 a n d h er M.S. in 1987 a n d Ph .D. in 1992 from Un ivers ity of Sou th ern Ca liforn ia (USC) a ll in E lect r ica l En gin eer in g. Her exper t is e a n d res ea rch in teres ts in clu de im a ge a n a lys is , com pu ter vis ion , a s well a s m u lt im edia m es s a gin g a n d colla bora t ion . From 1992 to 1997 , Dr . Ya n wa s a Res ea rch As s is ta n t Profes s or of Depa r tm en ts of Ps ych ia t ry a n d Ra diology of Un ivers ity of Pen n s ylva n ia . Sh e d irected th e Im a ge Proces s in g La b , a n d wa s res pon s ib le for p rovid in g a dva n ced im a ge proces s in g s olu t ion s to s tu dy n orm a l b ra in fu n ct ion s a n d ps ych ia t r ic d is orders . Sh e wa s th e Pr in cipa l In ves t iga tor a n d a Co-in ves t iga tor of m a n y m u lt i-m illion dolla r res ea rch gra n ts fu n ded by Na t ion a l In s t itu te of Men ta l Hea lth (NIMH) a n d Depa r tm en t of En ergy (DOE). Dr . Ya n h a s join ed Siem en s Corpora te Res ea rch , In c. a s a Mem ber of Tech n ica l S ta ff (MTS) s in ce1997 . Her m a in focu s h a s been m u lt im edia m es s a gin g, h eterogen eou s device colla bora t ion a n d rem ote m u lt im edia docu m en t a cces s in a lim ited com pu t in g en viron m en t a n d th eir a pp lica t ion s to m edica l im a gin g. Sh e h a s been res pon s ib le for m a n y Siem en s R&D project im plem en ta t ion s a n d deliver ies , a n d wa s th e lea d in g m em ber a n d in s t ru m en ta l to Siem en s fir s t a u tom a t ic lu n g n odu le detect ion p rodu ct .


147


Wh a t is th e Next Big Th in g a fter Sea rch ?

J am e s Shaw

Sen ior Softwa re En gin eer IBM Res ea rch

Tel: 914-784-7638 Fa x: 914-784-7455

Em a il: s h a wjc@u s .ibm .com

ABSTRACT Sea rch tech n ology h a s revolu t ion ized h ow people u s e th e Web. Wh a t is th e n ext b ig th in g th a t ca n im prove peop le’s on lin e exper ien ce? We believe th e a n s wer is web-ba s ed m u lt im oda l d ia logu e s ys tem s . With growin g a m ou n t of s t ru ctu red da ta on lin e, a va ila b ility of web gra ph ics ren der in g en gin e, a n d im proved s peech recogn it ion a n d s peech s yn th es is , it is pos s ib le to crea te web-ba s ed s ys tem s th a t ca n com m u n ica te n a tu ra lly with u s ers . To in tera ct with s u ch s ys tem s , u s ers con vey th eir in ten t th rou gh s peech a n d poin t in g devices u s in g b rows ers . In tu rn , com pu ters res pon d to u s ers ’ requ es ts by gen era t in g a ppropr ia te res pon s es th rou gh both a u tom a ted gra ph ics s yn th es is a n d s peech s yn th es is . Th rou gh th es e requ es ts a n d res pon s es , u s ers ca n rea ch th e des ired in form a t ion qu ick ly a n d effect ively a s if th ey a re in tera ct in g with a kn owledgea b le dom a in exper t or cu s tom er repres en ta t ive. In th is ta lk , we will des cr ibe a m u lt im oda l d ia logu e s ys tem , RIA, a n d d is cu s s tech n ica l ch a llen ges in des ign in g va r iou s com pon en ts . In a dd it ion , we propos e s evera l poten t ia l bu s in es s m odels for dep loyin g s u ch web-ba s ed m u lt im oda l d ia logu e s ys tem s . BIOGRAPHY J a m es Sh a w is cu r ren t ly a s en ior s oftwa re en gin eer a t IBM Res ea rch in Ha wth orn e, NY. His grou p , In telligen t Mu lt im edia In tera ct ion , is work in g on th e n ext gen era t ion h u m a n -com pu ter in ter fa ce to en h a n ce cu s tom ers ’ Web exper ien ce. By provid in g cu s tom ers con text -s en s it ive m u lt im oda l in tera ct ion s th a t in clu de rea l-t im e gra ph ic gen era t ion , m ou s e ges tu res , a n d n a tu ra l d ia logu e, cu s tom ers ca n fin d des ired in form a t ion or m erch a n dis e n a tu ra lly a n d effect ively with ou t lea rn in g to u s e th e s ys tem . Su ch m u lt im oda l s ys tem s h a ve m a n y com m ercia l a pp lica t ion s , s u ch a s a n a u tom a ted rea l-es ta te a gen t , t r a vel a gen t , or cu s tom er repres en ta t ive. J a m es Sh a w received h is Ph .D. degree in Com pu ter Scien ce from Colu m bia Un ivers ity. He developed MAGIC, a Web-ba s ed s u m m a r iza t ion s ys tem in m edica l dom a in . Ba s ed on da ta collected from m on itor in g m a ch in es in opera t in g room s , MAGIC gen era ted En glis h s u m m a ry of even ts occu r red du r in g h ea r t s u rger ies . In 2000 , h e join ed Siem en s Corpora te Res ea rch in Pr in ceton , NJ , a s a m em ber of tech n ica l s ta ff. At Siem en s , h e worked on colla bora t ive s ys tem s to en h a n ce cu s tom ers ’ b rows in g exper ien ce in reta il webs ites , a n d con ten t m a n a gem en t s ys tem s to im prove th e workflow of bu s in es s grou ps .


148


Ma ch in e Recogn it ion of Hu m a n Fa ces

Dr. We n-Yi Zhao

Mem ber of Tech n ica l S ta ff Sa rn off Corpora t ion Tel: 609-734-2725 Fa x: 609-734-2662

Em a il: wzh a o@s a rn off.com

ABSTRACT In recen t yea rs , fa ce recogn it ion (in clu d in g fa ce detect ion , fa cia l expres s ion recogn it ion in a b roa der s en s e) h a s a t t ra cted m u ch a t ten t ion beca u s e of it s poten t ia l com m ercia l a n d la w en forcem en t a pp lica t ion s . Th is is n ot pos s ib le with ou t s ign ifica n t tech n ica l a dva n ces m a de du r in g th e pa s t 30 yea rs . Even th ou gh cu r ren t m a ch in e recogn it ion s ys tem s h a ve rea ch ed a cer ta in level of m a tu r ity, th eir s u cces s is lim ited by th e con dit ion s im pos ed by m a n y rea l a pp lica t ion s . Th e p rob lem of m a ch in e recogn it ion of h u m a n fa ces con t in u es to a t t ra ct res ea rch in teres t from s evera l d is cip lin es s u ch a s im a ge p roces s in g, pa t tern recogn it ion / lea rn in g, n eu ra l n etworks , com pu ter vis ion , com pu ter gra ph ics a n d ps ych ology. Th e m a jor goa l of th is ta lk is to give a h igh -level review of th e s ta te-of-th e-a r t res ea rch a n d developm en t on fa ce recogn it ion a lgor ith m s a n d s ys tem s . In a dd it ion , I will d is cu s tech n ica l is s u es th a t we a re s t ill fa cin g a n d va r iou s ch a llen ges of pu s h in g th is tech n ology forwa rd . BIOGRAPHY Wen -Yi Zh a o received th e doctora l degree in elect r ica l en gin eer in g from th e Un ivers ity of Ma ryla n d a t College Pa rk in 2000 . He s tu d ied elect ron ic en gin eer in g with focu s on im a ge proces s in g a t th e Ts in gh u a Un ivers ity, Beijin g; elect r ica l en gin eer in g with focu s on com pu ter vis ion a t th e Un ivers ity of Virgin ia . From 1990 to 1993 , h e wa s a n elect r ica l en gin eer with Beijin g Hu a h u a n Corp . Ltd . Du r in g 1997 to 1998 , h e vis ited LG Elect ron ics Res ea rch Cen ter of Am er ica , In c., wh ere h e con du cted res ea rch in th e a rea s of video in dexin g a n d ret r ieva l, developm en t of MPEG-7 s ta n da rd . S in ce 2000 , h e h a s been work in g on va r iou s p rob lem s rela ted to im a ge/ video en h a n cem en t , m ot ion es t im a t ion , a n d a lign m en t of 2D-3D a n d 3D-3D da ta a t th e Vis ion Tech n ologies La b of Sa rn off Corpora t ion . Dr . Zh a o wa s a tu tor ia l s pea ker on th e s u b ject of fa ce recogn it ion a t ICIP 2003 . He is th e p rogra m co-ch a ir of IEEE In tern a t ion a l Works h op on An a lys is a n d Modelin g of Fa ces a n d Ges tu res (AMFG) 2003 . Dr . Zh a o is a m em ber of E ta Ka ppa Nu a n d Ph i Ka ppa Ph i. He is a ls o a m em ber of th e IEEE a n d th e IEEE Com pu ter Society.


149


Vir tu a lly Ph ys ica l Wh iteboa rds a n d In k In s ta n t Mes s a gin g

Zon-Yin Shae

IBM T.J . Wa ts on Res ea rch Cen ter

ABSTRACT Severa l workp la ce field s tu d ies h a ve s h own th e im por ta n ce of ph ys ica l wh iteboa rds wh ich a re a loca le for d is cu s s ion a n d colla bora t ion . However , ph ys ica l wh iteboa rds a re on ly vis ib le loca lly in on e p la ce. Th eir in form a t ion is n ot ea s ily a va ila b le for rem ote s ites . Es pecia lly, s t rokes wr it ten on th e wh iteboa rd with in k ca n n ot be era s ed or ed ited by rem ote u s ers . Hen ce, rea l-t im e m u lt i-u s er ph ys ica l wh iteboa rd colla bora t ion is lim ited loca lly to peop le in th e s a m e room . With th e recen t a dva n ce of tech n ology, vir tu a l s t rokes ca n be ca p tu red by low cos t elect ron ic pen s . Low cos t p rojectors ca n th en be u s ed to d is p la y th e s t rokes on th e wh iteboa rd . Con s equ en t ly, we ca n vir tu a lize th e ph ys ica l wh iteboa rd , a n d en a b le th e rem ote colla bora t ion for d is cu s s ion , des ign , a n d ed it in g in n etworked en viron m en t . At th e s a m e t im e, th e a dva n ta ges of ph ys ica l wh iteboa rds a re m a in ta in ed . Th e pu rpos e of th is p roject is to s tu dy th e va r iou s is s u es a n d poten t ia l a pp lica t ion s of th is n etworked vir tu a lly ph ys ica l wh iteboa rd s ys tem . Th e is s u es , for exa m ples , a re a u gm en ted rea lity in vir tu a l m eet in g room , in dexin g a n d s ea rch in g of th e s t roke m edia con ten ts , a n d s t rea m in g a n d broa dca s t in g m ech a n is m s . Th e poten t ia l a pp lica t ion s a re tea m colla bora t ion , colla bora t ive des ign , d is ta n ce edu ca t ion a n d lea rn in g. We a ls o exten d th is con cep t in to th e elect ron ic in k in s ta n t m es s a gin g u s in g perva s ive devices . BIOGRAPHY Zon -Yin Sh a e is a t th e IBM Wa ts on Res ea rch Cen ter , wh ere h e works in th e a rea of VoIP, SIP, m u lt im edia s t rea m in g, m edia en a b lin g e-bu s in es s a pp lica t ion s a n d th e u s e of m u lt im edia to b r idge ph ys ica l a n d vir tu a l en viron m en ts . He led IBM m u lt im edia s t rea m in g project u s ed for th e At la n ta Olym pic Ga m e. He is cu r ren t ly work in g on th e VoIP/ SIP con verged en terpr is e a pp lica t ion s , in fra s t ru ctu re a n d s ervices . Dr . Sh a e received th e B.S. a n d M.S. degrees in elect ron ic en gin eer in g from th e Na t ion a l Ch ia o-Tu n g Un ivers ity, Ta iwa n , 1976 a n d 1978 res pect ively, a n d th e Ph .D. degree in elect r ica l en gin eer in g from th e Un ivers ity of Pen n s ylva n ia , Ph ila delph ia , USA, 1989 . From 1980 to 1984 , before h e pu rs u ed h is Ph .D. degree, h e worked a s a n en gin eer in th e a rea s of com m u n ica t ion s ys tem a n d m icroprogra m m in g CPU des ign for s ign a l p roces s in g. S in ce Ma rch 1989 , h e h a s been with IBM Wa ts on Res ea rch Cen ter , New York . Dr . Sh a e h a s pu b lis h ed ten s of tech n ica l pa pers a n d a pp lied ten s U.S. pa ten ts . He h a s received va r iou s a wa rds from IBM Wa ts on Res ea rch Cen ter for h is con t r ibu t ion s in th e a rea of m u lt im edia com m u n ica t ion .


150


Au gm en ted Rea lity a n d It s In du s t r ia l Applica t ion s

Xiang Zhang

S iem en s Corpora te Res ea rch , In c. Tel: 609-734-3626 Fa x: 609-734-6565

Em a il: xia n gzh a n g@s iem en s .com

ABSTRACT Augm ented reality : Au gm en ted rea lity (AR) is th e tech n ology th a t p rovides th e u s er with a n en h a n ced vis u a liza t ion of th e rea l wor ld by s u per im pos in g th e rea l-wor ld view with a lign ed vir tu a l ob jects gen era ted by com pu ter a n d a dd it ion a l in form a t ion . Th e u s er ca n u s e AR to work with a n d exa m in e th e ph ys ica l wor ld , wh ile receivin g a dd it ion a l in form a t ion a bou t th e ob jects of in teres t th rou gh a d is p la y. In th is ta lk I will in t rodu ce s om e in du s t r ia l AR a pp lica t ion s I worked on recen t ly, p lea s e be a dvis ed th a t th is is ju s t a s m a ll pa r t of AR work a t S iem en s Corpora te Res ea rch , In c. S EAR: A m a in ten a n ce en gin eer wh o ta lks to pu m ps a n d p ipes m a y n ot s eem like th e idea l pers on to en t ru s t with keep in g a fa ctory ru n n in g s m ooth ly, bu t we h ope th a t ou r m obile Speech -En a bled Au gm en ted Rea lity (SEAR) fra m ework will en a b le s u ch beh a vior in th e fu tu re to be a n yth in g bu t s u s p iciou s ! In th is pa per we des cr ibe h ow th e SEAR fra m ework u s es ou r flexib le a n d s ca la b le vis ion -ba s ed loca liza t ion tech n iqu es to offer th e en gin eer a s ea m les s m u lt i-m oda l u s er in ter fa ce. Th is in ter fa ce ju xta pos es a gra ph ica l AR view with a con text -s en s it ive s peech d ia log con cern in g th e in du s t r ia l equ ipm en t loca ted in h is im m edia te vicin ity. Acces s 3D is a n AR a pp lica t ion th a t a llows th e u s er to s u per im pos e 3D com pu ter gen era ted gra ph ic m odels or texts on s ta t ic im a ges or video fra m es . In a dd it ion , Acces s 3D ca n be u s ed to in qu ire in form a t ion lin ked with th e res pect ive 3D m odels . Acces s 3D u s es VRML m odels for vis u a liza t ion . In ou r AR a pp lica t ion , th e vir tu a l 3D m odels a re d irect ly con ver ted from CAD da ta a n d ca n be h yper -lin ked to th e res pect ive CAD da ta ba s e. To s u per im pos e 3D m odels in cor rect a lign m en t with th e im a ge, VRML requ ires th e pa ra m eters of th e ph ys ica l ca m era (th a t ca p tu res th e im a ge or video) be ca lib ra ted exp licit ly. Th e AR views a re gen era ted by a lign in g th e vir tu a l ca m era with th e ph ys ica l ca m era in VRML vis u a liza t ion . In order to ob ta in cor rect ca m era ca lib ra t ion , we a pp ly da ta n orm a liza t ion in d ifferen t s ta ges of p roces s to in crea s e th e n u m er ica l s ta b ility. FARHMD: We a pp ly Fea tu re-ba s ed m ot ion t ra ck in g tech n ology for a u gm en ted rea lity (AR) with a n op t ica l-s ee-th rou gh h ea d-m ou n ted-d is p la y (HMD). Su ch AR s ys tem s ca n be u s ed in in du s t r ia l for t ra in in g a n d m a in ten a n ce. In AR, t ra ck in g m ea n s to ext ra ct th e 3D pos e (in clu d in g pos it ion a n d or ien ta t ion ) of th e viewer . In th e ca s e with a n op t ica l-s ee-th rou gh HMD, th e t ra ck in g is to recover th e pos it ion a n d or ien ta t ion of th e u s er ’s eye. To do s o, we a t ta ch a ca m era to th e HMD a n d a pp ly th e t ra ck in g a lgor ith m th a t m a kes u s e of th e n a tu ra l vis u a l fea tu res . Ou r exper im en ts s h ow th a t ou r fea tu re-ba s ed t ra ck in g h a s bet ter per form a n ce in m a n y ca s es th a n th a t of th e m a rker -ba s ed t ra ck in g s ys tem s -- in term of fa s ter fra m e ra te a n d m ore s ta b le s u per im pos it ion . BIOGRAPHY


151

Xia n g Zh a n g got h is BS a n d MS degrees from th e Ts in gh u a Un ivers ity in Beijin g. He join ed Siem en s Corpora te Res ea rch n ot lon g a fter h e fin is h ed h is Ph D s tu dy a t th e Un ivers ity of Flor ida in 1999 . At Siem en s Corpora te Res ea rch , In c., Xia n g Zh a n g h a s been doin g res ea rch a n d developm en t in th e a rea of a u gm en ted rea lity. His res ea rch in teres ts in clu de a u gm en ted rea lity vis u a liza t ion , ca m era ca lib ra t ion , vis u a l ba s ed m ot ion t ra ck in g, a n d ph ys ica l ba s ed s im u la t ion a n d vis u a liza t ion .

the 3 rd annual emerging information technology...

Documents