terminologi, klasifikasi & penamaan neoplasma
DESCRIPTION
TERMINOLOGI, KLASIFIKASI & PENAMAAN NEOPLASMA. NOZA HILBERTINA. TERMINOLOGI. Tumor : pembengkakan yg abnormal. Kedokteran modern. Neoplasma. Neoplasia = neoplasma = pertumbuhan baru an abnormal mass of tissue - PowerPoint PPT PresentationTRANSCRIPT
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1dr. Noza Hilbertina, M.Biomed, SpPA
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Tumor : pembengkakan yg abnormal Kedokteran
modern
Neoplasma
2dr. Noza Hilbertina, M.Biomed, SpPA
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Neoplasia = neoplasma = pertumbuhan baru
an abnormal mass of tissue the growth of which exceeds and is
uncoordinated with that of the normal tissues
persists in the same excessive manner after cessation of the stimuli which evoked the change (Willis : British oncologist)
3dr. Noza Hilbertina, M.Biomed, SpPA
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Oncology : oncos (yunani) = tumor ilmu yang mempelajari ttg tumor
Kanker : istilah umum untuk tumor ganas Crab (latin)
Tumor berasal dari transformasi neoplastik dari sel yang berinti di dlm tubuh
Sel neoplastik = sel-sel yang telah bertransformasi
4dr. Noza Hilbertina, M.Biomed, SpPA
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Transformasi melibatkan serangkaian perubahan genetik lolos dari mekanisme pengaturan pertumbuhan normal secara permanen
Proliferasi sel yang berlebihan dan tidak teratur
OTONOM
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Perangai tumor : jinak, ganas Histogenetik : sel asal tumor
PENTING UNTUK MERENCANAKAN PENATALAKSANAAN
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Non invasif dan tetap terlokalisir Pertumbuhan lambat Kemiripan histologi dengan jaringan
asal
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Invasif shg dpt menyebar secara langsung atau mlli metastasis
Pertumbuhan relatif cepat Gambaran histologis lebih bervariasi
dibandingkan dengan jaringan asal
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Tumor borderline : histologi intermediet antara jinak dan ganas
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Karakteristik Jinak Ganas
Diferensiasi /anaplasia
Diferensiasi baik/typical
Kurangnya diferensiasi/atypical
Derajat pertumbuhan
Progresif, lambat, menetap atau regresi, mitosis jarang
Lambat-cepat, byk mitosis
Invasi lokal Kohesif, ekspansif, batas tegas, tdk menginfiltrasi/invasi jar sktr
Invasif lokal, infiltrasi jar sktr
Metastasis Absen Sering terjadidr. Noza Hilbertina, M.Biomed, SpPA 10
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Berdasarkan sel asal Ditentukan secara histologi Dapat di grade kan bdsrkan kemiripan
histologi dg jar asal Grade histologi berkorelasi dg perangai
klinis tumor
11dr. Noza Hilbertina, M.Biomed, SpPA
KLASIFIKASI WHO
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Kelenjar normal
Adenoma
Adenokarsinoma grade II
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Sel epitel : sel skuamosa, sel transisional, sel basal, sel galndular
Jaringan penyambung : otot polos, otot lurik, jar lemak, p. darah, tulang, kartilago, mesothel, synovium
Organ limfoid dan hematopoitik
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Masing-masing nama tumor menunjukkan karakteristik tersendiri (term of cause, appearance and behaviour)
Diagnosis dan penamaan yang akurat sgt penting tatalaksana optimal
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-----OMA Tumor epitel jinak : ---- papilloma,
adenoma Tumor jar penyambung jinak : prefix =
sel asal tumor---oma Tumor epitel ganas : karsinoma Tumor jar penyambung ganas : sarkoma Sel darah : ----Aemia (Leukaemia) kecuali anemia ; bukan neoplastik
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TIPE JINAK GANAS
EPITELIAL
Squamous cell Squamous cell papilloma
Squmous cell carcinoma
Transisional
Basal cell
Glandular Adenoma Adenocarcinoma
MESENCHYMAL
Smooth muscle leiomyoma Leiomyosarcoma
Striated muscle
Adipose tissue
Blood vessel Angioma
Bone Osteosarcoma
Cartilage
Mesothelium
Synovium Synovioma 16dr. Noza Hilbertina, M.Biomed, SpPA
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Feature Carcinoma Sarcoma
Asal Epitelial Jar Penyambung
Perangai Ganas Ganas
Frekuensi Sering Jarang
Rute Metastasis tersering
Limfe Darah
Fase in-situ (+) (-)
Kelompok Usia
Biasanya > 50 thn
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Berdasarkan org yg pertama kali mengenali atau
menjelaskan deskripsi tumor ttt. Burkitt’s lymphoma Ewing’s sarcoma Grawitz tumour Wilm’s tumour
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Melanoma : tumor ganas melanosit Lymphoma : tumor ganas sel limfoid Myeloma ; tumor ganas sel plasma
MALIGNANT ------------------------
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Granuloma Tuberkuloma Atheroma Mycetoma
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TERATOMA : neoplasma yg dibentuk oleh sel yang menunjukkan ketiga lapis sel germinal : ectoderm, mesoderm, endoderm
TUMOR EMBRYONAL (---blastoma) : retinoblastoma, neuroblastoma, hepatoblastoma.
TUMOR CAMPUR : kombinasi tipe sel spt pleomorfik adenoma, fibroadenoma, carsinosarcoma
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APUDomas DAN TUMOR KARSINOID APUD = Amine content and/or Precursor
Uptake and Decarboxylation) sel dari sistim endokrin diffusa spt sel C dari kelj tiroid, sel islet langerhans.
HAMARTOMAS : tumour-like lesion, selalu jinak, tdr dr dua atau lebih tipe sel matur yg secara normal ditemukan di organ tempat lesi tsb berasal
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KISTA : ruang terisi cairan dan di lapisi oleh epitel
Tipe-tipe kista :- Kongenital : kista branchial, thyroglossal- Neoplastik : cystadenoma, cystadenocarcinoma- Parasitik : kista hydatid ec Echinococcus
granulosus- Retensi : kista epidermoid, kista pilar- Implantasi : akibat pembedahan atau
implantasi accidental dr epidermis
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General And Systematic Pathology : Edited JCE Underwood, Churchill Livingstone, Toronto, 2004
Robbins and Cotran Pathologic Basis of Disease : Kumar, Abbas, Fausto, Elseviers Saunders, 2009
Pathology Illustrated : Peter S Macfarlene, Churchill Livingstone, Toronto, 2000
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