www.lipotech.com.ar

Technological innovation meeting the highest quality standards and our customers’ needs.

ABOUT US

SOME OF OUR MINERAL SOURCES

APPLICATIONS

SERVICES

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14PUBLISHED SCIENTIFICPAPER

INDEX

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LIPOTECH S.A. leads the innovation of mineral sources and microencapsulation of substances.

ABOUT US

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26 international patents.

More than 20 scientific publications in specialized journals.

Our products are used by the best food companies in the world.

Lipotech S.A, founded and led by scientific researchers, has been a world leading company in research, development and production of mineral additives for the food industry for over 20 years. Our unique products have been a reference source forinternational organizations all over the world.

Our stabilized mineral salts, liposome-encapsulated active ingredients, and alltechnology processes used to manufacture them, were both developed and patented by our company.

All of our products are endorsed by several specialized publications, and we have worked together with United Nations experts, specialized in micro and macronutrients, developing governmental food fortification plans.

Our responsibility, experience, reliability and commitment have made national and international leading companies select us as their suppliers.

We produce mineral and functional ingredients,designed for the Food,Nutraceutical,Pharmaceutical andCosmetic industries.

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www.lipotech.com.ar

Our mineral salts not only add value to our customers’ products by giving them specific nutritional properties, but also they pave the way for focusing their business on special nutritional needs and better positioning in the market. By incorporating essential minerals, standard products become a functional alternative for specific market segments such as infants and elderly people.

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SOME OF OUR MINERAL SOURCES

BIO MIX A.A.S.

BioZn A.A.S.

ZINC

Sulfato Cuprico A.A.S.

Gluconato de Cobre A.A.S.

COPPER

Biolactato de Magnesio A.A.S.

Gluconato de Magnesio A.A.S.

MAGNESIUM

Biofumarato de Potasio A.A.S.

Fumarato de Potasio A.A.S.

Cloruro de Potasio A.A.S.

POTASSIUM

Biocal A.A.S

Cloruro de Calcio A.A.S.

Biolactato de Calcio A.A.S.

Fosfato Tricalcico A.A.S.

CALCIUM

Biofer

Bioferroso A.A.S.

Pirofosfato Ferrico A.A.S. (Fe 15.0%)

Pirofosfato Ferrico A.S.H.S. Ultra (Fe 5,8%)

Bioferroso A.A.S. -m

Pirofosfato Ferrico A.A.S. -m

IRONOur Research and Development departmentfocuses on meeting our customers’ needsby providing them assistance fromproduct development to productlaunch, and by developing newproducts and customizedpre-mixture designsof mineralcompounds.

Stabilized Mineral Salts Mixtures.

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APPLICATIONS

Fluid and powder milkand dairy drinks.

Chocolate and chocolate milk.

Cheese, yoghurt and desserts.

Bakery products, pasta, cookies and snacks.

Flavored water and sports drinks.

Fruit pulp, concentrate,juice and powder.

Soy products and beverages.

Dietary Supplements.

Multi-mineral and multi-vitamin formulations.

Balanced food for farm animals and poultry.

Liposome microencapsulation technology guarantees quality and safety for your products.

With more than 20 years in the liposome manufacturing industry, Lipotech leads the world market of substancemicroencapsulation.

Liposomes increase the therapeutic margin and durability of highly sensitive and difficult-to-handle active ingredients, in all its supply forms.

Our Research and Developmentdepartment focuses on meeting our customers’ needs by providing them assistance, from product development to product launch, and by developing newproducts and customized pre-mixturedesigns of mineral compounds.

In order to facilitate our products uses in production processes, we offer our customers stabilized mineral salts premixes.

SERVICES

F O O D A N DB E V E R A G E FORTIFICATION

STABILIZED MINERALADDITIVES

TAILOR-MADE SUBSTANCEMICROENCAPSULATION.

TAILOR-MADE PRE-MIXTURE MICROENCAPSULATION.

High solubilityExcellent bioavailabilitySensorial characteristics of fortified food are unaltered.

www.lipotech.com.ar

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PUBLISHED SCIENTIFICPAPERS

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J.R. Boccio, M.B. Zubillaga, R.A. Caro, C.A. Gotelli, M.J. Gotelli and R. Weill (1995). New procedure to fortify fluid milk and derivatives with iron. Comparative study in mice. J.Nutr. Sci. Vitaminol. 41: 619-626.

M.B. Zubillaga, R.A. Caro, J.R. Boccio, C.A. Gotelli,M.J. Gotelli and R. Weill (1996). New procedure to fortify fluid milk with iron: metabolic and biochemical study in rats. Nutr. Res. 16 (1): 131-137.

A. Gotelli, M. J. Gotelli, J.R. Boccio, M.B. Zubillaga, R.A. Caro, H. García del Río and R. Weill (1996). Bioavailability ofmicroencapsulated ferrous sulfate in fluid milk. Studiesin human beings. Acta Physiologica Pharmacologica etTherapeutica Latinoamericana. 46: 239-245.

Boccio, J.; Zubillaga, M.; Caro, R.; Gotelli, C.; Gotelli, M. and Weill, R. (1996). Bioavailability and Stability ofMicroencapsulated Ferrous Sulfate in Fluid Milk. J. Nutr. Sci. Vitaminol. 42: 233-239.

Boccio, J.; Zubillaga, M.; Caro, R.; Gotelli, C.; Gotelli, M. and Weill, R. (1997). New procedure to fortify dairy products with microencapsulated ferrous sulfate. Iron Deficiency. 213-229.

Boccio, J.; Zubillaga, M.; Caro, R.; Gotelli, C.; Gotelli, M. and Weill, R. (1997). New procedure to fortify fluid milk and dairy products with high-bioavailable ferrous sulfate. Nutrition Reviews. 55: 240-246.

Boccio, J.; Zubillaga, M.; Caro, R.; Lysionek, A.; Gotelli, C.; Gotelli, M. and Weill, R. (1998). Bioavailability, Mechanism of Absorption and Toxicity of Microencapsulated Iron (II)

Sulfate. Studies in Mice. Biological Trace Element Research. 62: 65-73.

Boccio, J.; Zubillaga, M.; Caro, R.; Lysionek, A.; Calmanovici, G., Sarabia, M., SalgueiroJ. and Weill, R. (1998). Microencapsulated Ferrous Sulfate to Fortify Cow Milk. Absorption and Distribution Studies in Mice. J. Nutr. Sci. Vitaminol. 44: 381-389.

E. Lysionek, M. B. Zubillaga, G. P. Calmanovici, M. J.Salgueiro, M. I. Sarabia, A. D. Barrado, R. A. Caro and J. R. Boccio. (1998). Modification of the ferrozine technique to analyze iron contents in different foods. Comparative study using an internal standard as reference methodology.Biological Trace Element Research. 65: 87-94.

Raúl Uicich, Fernando Pizarro, Carlos Almeida, María Diaz, José Boccio, Marcela Zubillaga, Esteban Carmuega and Alejandro O’Donnell. (1999). Bioavailability of microencapsulated ferrous sulfate in fluid cow’s milk.Studies in human beings. Nutr. Res. 19 (6): 893-897.

José Boccio, Marcela Zubillaga, Alexis Lysionek, Ricardo Caro. (1999). Bioavailability of a new iron source used in the fortification of fluid milk. Importance of its use inchildren after their nursing. NAHRES. 44: 13-15.

José Boccio, Marcela Zubillaga, Alexis Lysionek, Ricardo Caro and Ricardo Weill. (2000). Bioavailability of a new iron source used in the fortification of fluid milk. Importance of its use in children after their nursing. NAHRES. 48: 19-23.

Alexis Lysionek, Marcela Zubillaga, Jimena Salgueiro,María Sarabia, Ricardo Caro, Ricardo Weill and José

Boccio. (2000). Study of industrial microencapsulatedferrous sulfate by means of the prophylactic-preventive method to determine its bioavailability. J. Nutr. Sci.Vitaminol. 46: 125-129.

Alexis Lysionek, Marcela Zubillaga, Jimena Salgueiro,Ricardo Caro, and José Boccio. (2001). Bioavailability studies of a new iron source by means of the prophylactic- preventive method in rats. Biol Trace Elem Res; 84: 123-128.

Alexis Lysionek, Marcela Zubillaga, Jimena Salgueiro,Ricardo Caro, Ricardo Weill and José Boccio. (2001).Bioavailability study of dried microencapsulated ferrous sulfate SFE-171 by means of the prophylactic-preventive method to determine its bioavailability.J. Trace Elements Med. Biol. 15: 255-259.

Alexis Lysionek, Marcela Zubillaga, Jimena Salgueiro,Ricardo Caro, Ricardo Weill and José Boccio. (2002).Bioavailability of microencapsulated ferrous sulfate inpowdered milk produced from fortified fluid milk: aprophylactic study in rats. Nutr. 18:279-281.

Lysionek A, Zubillaga M, Salgueiro J, Caro R, Segal M,Shafran N, Shapira N, Boccio J. (2002). Petit-Suissecheese as vehicle for iron fortification. Bioavailability study of two microencapsulated iron sources. J. Nutr. Sci.Vitaminol. 48:315-317.

Battistelli M., Falcieri E., Salucci S., De Paoli T., Riccardi B. Department of Biomolecular Sciences (DiSB), UrbinoUniversity Carlo Bo, 61029 Urbino (PU),Italy. Lipotech S.A. Tres Arroyos 329 -Buenos Aires Argentina –MORPHOLOGICAL EVALUATION OF LIPOSOMAL CARRIERS

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info@lipotech.com.ar www.lipotech.com.ar

+54 11 4627-5921+54 11 4627-3215+54 11 4489-4555

Parque Industrial La CantábricaTres Arroyos 329 HaedoBuenos Aires - República Argentina