technological advances in longer-acting factor replacement therapy for hemophilia
DESCRIPTION
Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia. Program Goals. Factor Replacement Therapy. Challenges of Factor Replacement Therapy. Half-Life Extension Technology. rFIX Fc Fusion Protein (rFIX-Fc). rFIX-Fc (cont). rFIX Albumin Fusion Protein (rFIX-FP). - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/1.jpg)
Technological Advances in Longer-Acting Factor
Replacement Therapy for Hemophilia
![Page 2: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/2.jpg)
Program Goals
![Page 3: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/3.jpg)
Factor Replacement Therapy
![Page 4: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/4.jpg)
Challenges of Factor Replacement Therapy
![Page 5: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/5.jpg)
Half-Life Extension Technology
![Page 6: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/6.jpg)
rFIX Fc Fusion Protein (rFIX-Fc)
![Page 7: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/7.jpg)
rFIX-Fc (cont)
![Page 8: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/8.jpg)
rFIX Albumin Fusion Protein (rFIX-FP)
![Page 9: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/9.jpg)
rFIX-FP (cont)
![Page 10: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/10.jpg)
GlycoPEGylated rFIX (N9-GP)
![Page 11: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/11.jpg)
N9-GP (cont)
![Page 12: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/12.jpg)
GlycoPEGylated rFVIII (N8-GP)
![Page 13: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/13.jpg)
![Page 14: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/14.jpg)
rFVIII Fc Fusion Protein (rFVIII-Fc)
![Page 15: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/15.jpg)
rFVIII-Fc (cont)
![Page 16: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/16.jpg)
rFIX-Fc: Phase 3 Studies Dosing
![Page 17: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/17.jpg)
rFIX-Fc: Bleeding Rate by Dose
![Page 18: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/18.jpg)
rFVIII-Fc: Bleeding Rate by Dose
![Page 19: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/19.jpg)
rFVIII-Fc: Dosing Frequency at the End of the Study Period
![Page 20: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/20.jpg)
Summary
![Page 21: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/21.jpg)
Clinical Impact of Half-life Extension
![Page 22: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/22.jpg)
Abbreviations
![Page 23: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/23.jpg)
References
![Page 24: Technological Advances in Longer-Acting Factor Replacement Therapy for Hemophilia](https://reader035.vdocuments.us/reader035/viewer/2022070420/56815e79550346895dccfb81/html5/thumbnails/24.jpg)
References (cont)