Teaching Students in Faculty of Arts and Science Pathophysiology

Mingyao Liu

Professor of Surgery

Faculty of Medicine, University of Toronto

November 21, 2009, Shanghai, China

Outline

• Merge of universities, the bigger the better?

• University of Toronto

• Human biology programs

• Teaching human biology by faculties from Medicine

• Translational medicine

People58,915 undergraduates

12,287 graduate students

International Students: 5,312 undergraduate (9%)

1,753 graduate (15%)

456 post-doctoral fellows

1123 clinical and research fellows

ResourcesFaculty:

2,159 tenure/tenure-stream 5,461 clinical faculty

Annual operating budget of $1.8B

One of the top 5 research libraries in North America

with over 15 million holdings

Infrastructure3 campuses

18 faculties

841 undergraduate programs

520 graduate programs

14 professional Programs

This is U of T...

Excellence at UofT

• 24th out of 500 in Shanghai Jiao Tong University Ranking on research intensity• 1st in Canada and 19th in North America (2007)•Publishes more science research paper than any public university in North America• Excellence in disciplines across major spectrum

Source: Times Higher Education Supplement, 2008

Prodigious Quality

AAU: Association of American Universities

Medicine and Health Sciences

A corridor to 10 major teaching health science centres, the Ontario Agency for Health Protection and Promotion and the MaRS Convergence Centre:

• UofT ranked sixth in clinical medicine and 14th in life sciences in scientific performance (HEEACT, 2009)• 6,835 separate research grants (2007) • > $550 million in annual funding • 1900 faculty, including 156 Canada Research Chairs and 70 Fellows of the Royal Society of Canada• over 5,000 clinical faculty and over 6,000 students in over 8 Faculties and schools

Source: Times Higher Education Supplement, 2008

Strik

ing

Qua

lity

Thomson ISI US and Canadian University Indicators, Deluxe and Standard Editions 2007

Three Campuses

2006 Enrolment:

Mississauga: 9,669

St. George: 50,871

Scarborough: 9,603

Faculty of Arts and Science: over 50,000 undergraduate students

Human Biology ProgramsEnvironment & Health Genes, Genetics & Biotechnology Global Health Health & Disease Health Care Ethics Human Biology Neuroscience

HMB201H - Introduction to Genes, Genetics and Biotechnology HMB202H - Introduction to Health and Disease HMB203H - Introduction to Global Health HMB210H - Scientific Controversies and Misconceptions HMB301H - Biotechnology HMB302H - Vertebrate Histology and Histopathology HMB303H - Global Health and Human Rights HMB304H - Biomedical Visualization HMB306H - Epistemological Ethics in MedicineHMB310H - Laboratory in Neuroscience HMB314H - Laboratory in Human Biology HMB325H - Statistics Applied to Human BiologyNEW350H - Selected Topics: AIDS in Africa, Challenges and Successes HMB397H - Scientific Communication

HMB402H - Bench-to-bedside: translating lab research into clinical practice HMB422H - Seminar in Health and Disease HMB430H - Trends in Neuroscience HMB434H - Complementary and Alternative Medicine HMB435H - Topics in Molecular Cell Biology HMB436H - Human Fungal Interaction HMB441H - Genetics of Human Disease HMB444H - Human Biology and Human Destiny: Science, Popular Science, and Science Fiction HAJ453H - AIDS: A Global Perspective JEH455H - Current Issues in Environment and Health HMB472H - Exercise Physiology HMB473H - Exercise and Mental Health HMB489H - Advanced Laboratory in Human Biology

Full Year Research ProjectsHMB399Y - Independent Experiential Study Project HMB400Y - Research Project in Neuroscience HMB498Y - Research Project in Global Health HMB499Y - Research Project in Human Biology

Computer Science Medicine

MARSCCBR Dan

MSHUHNHSC

St. George Campus & Hospitals

HMB402H – Bench-to-bedside: translating lab research to clinical practice

• Professor John Marshall– Sepsis clinical trials– Inflammation and apoptosis– Student presentations

• Professor Mingyao Liu– Acute lung injury and lung transplantation– Nanoparticle based drug delivery in treatment of acute lung injury– Student presentations

• Professor Heather Ross– Incorporating a transplanted heart– Remote ischemic pre-conditioning– Student presentations

Acute Lung Injury: from Molecular Mechanism to Nano-Medicine

Mingyao Liu, MD, MScProfessor of Surgery, Medicine and Physiology

Director, International Research Relations

Faculty of Medicine, University of Toronto

Senior Scientist

Director, Center for Research Education and Training

University Health Network Toronto General Research Institute

Outline

• A history of ARDS• Conflicts in treatment of ARDS• Ventilator-induced lung injury • Mechanotransduction• Src inhibition as a potential therapy• Nano-particle based drug delivery

HMB402HIF Bench-to-Bedside: Translating Lab Research into Clinical Practice

Module 2-2: Nanotechnology in Lung Injury

Instructors: Mingyao Liu, MD, MSc

Shan-Yu Fung, BSc, MASc, PhDOctober 23, 2009

Module 2-2 Course Outline

• Introduction to Nanotechnology– Historical background– What is nanotechnology?– Molecular self-assembly

• Nanotechnology in medicine– Nanoparticles for drug delivery– Self-assembling peptide based nano-delivery: case studies

• Nanotechnology in Lung Injury– Nanoparticles for pulmonary delivery– Nano-drug delivery for acute lung injury: case studies

Student Presentation

• Every student chose a paper related to selected subject

• 10 minutes slides presentation

• 5 minutes question period

• Scored by students– Scientific contents– Critical thinking– Presentation (visual, voice, eye contact...)

Summary

• Synergy between Faculty of Medicine and Faculty of Arts and Science

• Considering the career pathways for students

• Training the trainees (post-doc and students)

• Participation, ability and knowledge